Prostaglandins, leukotrienes, and essential fatty acids最新文献

英文中文

Plasma saturated fatty acids are inversely associated with lean mass and strength in adults: NHANES 2011–2012 血浆饱和脂肪酸与成人瘦体重和力量呈负相关：NHANES 2011-2012

IF 3

Prostaglandins, leukotrienes, and essential fatty acids

Pub Date : 2025-01-30 DOI: 10.1016/j.plefa.2025.102667

Heitor O. Santos, Rafaela Nehme, Larissa S. Limirio, Maria Eduarda de F. Mendonça, Flávia M.S. de Branco, Erick P. de Oliveira

Background & aims

Several studies have suggested that increased intake of saturated fatty acids (SFAs) may have a pro-inflammatory effect, potentially impacting muscle mass and strength. However, the relationship of plasma SFAs and their subtypes (which reflect dietary SFA intake) with muscle mass and strength remains poorly understood. This study aimed to evaluate the association of plasma SFAs with lean mass and handgrip strength in adults.

Methods

A cross-sectional study was conducted with 896 participants aged 20-59 years, selected from a subsample of the National Health and Nutrition Examination Survey (NHANES) 2011–2012. Total plasma SFAs and their subtypes were detected using gas chromatography-mass spectrometry. Lean mass was assessed using dual-energy X-ray absorptiometry, with evaluations of both total lean mass and appendicular lean mass. Muscle strength was measured using a handgrip dynamometer, with combined grip strength calculated by summing the highest values from each hand. Linear regression analysis was conducted to examine the association between plasma SFAs, lean mass, and handgrip strength, adjusting for potential confounders.

Results

Total lean mass was negatively associated with total plasma SFAs and several of their subtypes such as plasma levels of stearic acid, palmitic acid, arachidic acid, tricosanoic acid, lignoceric acid, and docosanoic acid. Similarly, appendicular lean mass was negatively associated with total plasma SFAs, as well as with several specific subtypes, including palmitic acid, stearic acid, margaric acid, pentadecanoic acid, and myristic acid. Handgrip strength also demonstrated a negative association with total plasma SFAs, including specific subtypes such as lauric acid, palmitic acid, capric acid, margaric acid, pentadecanoic acid, and myristic acid.

Conclusion

Total plasma SFAs and several of their subtypes are inversely associated with lean mass and muscle strength in adults.

背景,几项研究表明，饱和脂肪酸（sfa）摄入量的增加可能具有促炎作用，可能会影响肌肉质量和力量。然而，血浆SFA及其亚型（反映膳食SFA摄入量）与肌肉质量和力量的关系仍然知之甚少。本研究旨在评估成人血浆sfa与瘦体重和握力的关系。方法选取2011-2012年国家健康与营养调查（NHANES）的子样本，对896名年龄在20-59岁之间的参与者进行横断面研究。采用气相色谱-质谱法检测血浆总sfa及其亚型。采用双能x线吸收仪评估瘦质量，同时评估总瘦质量和阑尾瘦质量。肌肉力量是用握力计测量的，通过将每只手的最大值相加来计算综合握力。进行线性回归分析以检验血浆sfa、瘦质量和握力之间的关系，并对潜在的混杂因素进行调整。结果总瘦体重与血浆总sfa及其几个亚型（硬脂酸、棕榈酸、花生四酸、三糖酸、木质素酸和二十二糖酸）水平呈负相关。同样，阑尾瘦质量与血浆总sfa以及几种特定亚型呈负相关，包括棕榈酸、硬脂酸、人造黄油酸、棕榈酸和肉豆汁酸。握力也与血浆总sfa呈负相关，包括特定亚型，如月桂酸、棕榈酸、癸酸、人造黄油酸、五酸和肉豆酱酸。结论血浆总sfa及其几种亚型与成人瘦质量和肌力呈负相关。

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引用次数: 0

Association between the COX-2 rs689466 polymorphism and antipsychotic treatment: Impact on HDL cholesterol changes in clozapine-treated psychosis patients COX-2 rs689466多态性与抗精神病治疗的关系：对氯氮平治疗精神病患者HDL胆固醇变化的影响

IF 3

Prostaglandins, leukotrienes, and essential fatty acids

Pub Date : 2025-01-29 DOI: 10.1016/j.plefa.2025.102665

Sergej Nadalin , Ivan Ljoka , Aleksandar Savić , Ante Silić , Vjekoslav Peitl , Dalibor Karlović , Maja Vilibić , Lena Zatković , Alena Buretić-Tomljanović

Several studies have shown antipsychotic effects of the selective cyclooxygenase-2 (COX-2) inhibitor celecoxib as an add-on treatment to antipsychotic treatment. The functional rs689466 (A/G) polymorphism in the gene encoding COX-2 (also known as the prostaglandin-endoperoxide synthase 2 gene) has been correlated with schizophrenia risk and the niacin skin flush response among chronic patients under antipsychotic treatment. Here, we investigated whether this polymorphism was associated with antipsychotic treatment in a group of total psychosis patients (N = 186), as well as a subgroup of patients treated with clozapine (N = 74). Antipsychotic-naïve first-episode patients and non-adherent chronic psychosis patients were genotyped by polymerase chain reaction/restriction fragment length polymorphism analysis. At baseline and after 8 weeks of treatment with various antipsychotic medications, we assessed the patients’ Positive and Negative Syndrome Scale (PANSS) scores, factors, and metabolic syndrome-related parameters, including fasting plasma lipid and glucose levels and body mass index. In the total patient group, the COX-2 polymorphism was not associated with PANSS psychopathology scores or metabolic parameters. However, in the subgroup of patients treated with clozapine, the COX-2 polymorphism was associated with changes in plasma HDL cholesterol. Specifically, compared to patients homozygous for the A allele, the subgroup of patients treated with clozapine and positive for the G allele (i.e., GG or AG genotype) exhibited significantly higher increases in HDL cholesterol levels. The COX-2 polymorphism had a moderate effect size but made a relatively weak contribution to variations in the HDL cholesterol level (∼9.6 %).

一些研究表明选择性环氧化酶-2 （COX-2）抑制剂塞来昔布作为抗精神病治疗的附加治疗具有抗精神病作用。编码COX-2（也称为前列腺素内过氧化物合成酶2基因）的基因rs689466 （A/G）多态性与接受抗精神病药物治疗的慢性患者的精神分裂症风险和烟酸皮肤潮红反应相关。在这里，我们研究了这种多态性是否与一组全精神病患者（N = 186）以及一组接受氯氮平治疗的患者（N = 74）的抗精神病药物治疗有关。Antipsychotic-naïve首发患者和非依从性慢性精神病患者采用聚合酶链反应/限制性片段长度多态性分析进行基因分型。在基线和使用各种抗精神病药物治疗8周后，我们评估了患者的阳性和阴性综合征量表（PANSS）评分、因素和代谢综合征相关参数，包括空腹血脂和血糖水平以及体重指数。在整个患者组中，COX-2多态性与PANSS精神病理评分或代谢参数无关。然而，在接受氯氮平治疗的患者亚组中，COX-2多态性与血浆高密度脂蛋白胆固醇的变化有关。具体来说，与A等位基因纯合子的患者相比，接受氯氮平治疗且G等位基因阳性（即GG或AG基因型）的患者亚组的HDL胆固醇水平明显升高。COX-2多态性具有中等效应大小，但对HDL胆固醇水平的影响相对较弱（约9.6%）。

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引用次数: 0

Effects of seal oil supplementation on lipid profile biomarkers: A systematic review and meta-analysis of randomized controlled trials 海豹油补充对脂质生物标志物的影响：随机对照试验的系统回顾和荟萃分析

IF 3

Prostaglandins, leukotrienes, and essential fatty acids

Pub Date : 2025-01-29 DOI: 10.1016/j.plefa.2025.102666

Mariano Gallo Ruelas , Ivo Queiroz , Túlio Pimentel , Arthur Henrique Tavares , Maria L.R. Defante , Lucas M. Barbosa , Igor Eckert

Background

Seal oil (SO) supplementation has been purported to have cardiovascular health benefits due to its content of omega-3 fatty acids; however, the clinical evidence base for this intervention has yet to be comprehensively assessed.

Objective

We aimed to evaluate the effects of oral SO supplementation on lipid profile biomarkers.

Methods

A systematic search was performed on Pubmed, Embase, Web of Science and Cochrane Library, from inception to August 2024. Only randomized controlled trials (RCTs) assessing the effect of SO on lipid profile biomarkers were included. A random-effects meta-analysis was applied to determine the overall effect estimate. The certainty of evidence (CoE) was evaluated using the GRADE approach.

Results

Nine RCTs were included in the review after the screening of 242 studies, comprising a total of 626 patients. Supplementation of SO resulted in no statistically significant effects on LDL-C (MD -0.07 mmol/L; 95 % CI [-0.19, 0.05]; CoE: Low) and total cholesterol (MD -0.12 mmol/L; 95 % CI [-0.30, 0.06]; CoE: Very low). There were statistically significant results of modest-to-trivial clinical importance on triglycerides (MD -0.19 mmol/L, 95 % CI [-0.30, -0.08]; CoE: Low) and trivial importance on HDL-C (MD 0.07 mmol/L, 95 % CI [0.003, 0.13]; CoE: Very low).

Conclusion

There is no sufficiently certain evidence to determine the effects of SO on cardiovascular lipid biomarkers. Our analyses may suggest a modest-to-trivial, clinically uncertain beneficial effect on triglyceride levels; and little to no effect on LDL-C. Effect estimates for HDL-C and total cholesterol levels were highly uncertain. Further evidence is required to conclusively determine the effects of oral SO on lipid biomarkers.

Protocol registration number

CRD42024583739

海豹油（SO）补充剂被认为对心血管健康有益，因为它含有omega-3脂肪酸；然而，这种干预的临床证据基础尚未得到全面评估。目的评价口服SO补充剂对血脂生物标志物的影响。方法系统检索Pubmed、Embase、Web of Science和Cochrane Library，检索时间为建站至2024年8月。仅纳入了评估SO对血脂生物标志物影响的随机对照试验（rct）。采用随机效应荟萃分析确定总体效应估计。使用GRADE方法评估证据的确定性（CoE）。结果在242项研究筛选后，纳入9项rct，共纳入626例患者。补充SO对LDL-C的影响无统计学意义(MD -0.07 mmol/L；95% ci [-0.19, 0.05]；CoE：低)和总胆固醇(MD -0.12 mmol/L；95% ci [-0.30, 0.06]；CoE：非常低)。甘油三酯的临床重要性有统计学意义（MD -0.19 mmol/L, 95% CI [-0.30, -0.08]）；CoE：低)，对HDL-C不重要(MD 0.07 mmol/L, 95% CI [0.003, 0.13]；CoE：非常低)。结论目前尚没有足够的证据表明大豆油对心血管脂质生物标志物的影响。我们的分析可能表明对甘油三酯水平有轻微到微不足道的、临床不确定的有益影响；对LDL-C几乎没有影响对HDL-C和总胆固醇水平的影响估计高度不确定。需要进一步的证据来确定口服SO对脂质生物标志物的影响。协议注册号crd42024583739

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引用次数: 0

Depression and anxiety in the pregnant Omani population in relation to their fatty acid intake and levels 阿曼孕妇的抑郁和焦虑与脂肪酸摄入量和水平的关系

IF 3

Prostaglandins, leukotrienes, and essential fatty acids

Pub Date : 2025-01-28 DOI: 10.1016/j.plefa.2025.102668

Mohammed Al Sinani , Mark Johnson , Michael Crawford , Mohammed Al Maqbali , Samir Al-Adawi

Introduction

Maternal depression during and after pregnancy is a worldwide public concern. Low omega-3 FAs levels and intake in women during pregnancy were associated with a high rate of maternal depression and poor pregnancy outcomes. The study examines the association between FAs intake and levels and prenatal depressive and anxiety symptoms among pregnant Arabic-speaking women in Oman.

Methodology

In 302 pregnant Omani women, level of depression and anxiety is assessed at the 8–12 and 24–28 weeks of pregnancy using the Arabic version of (EPDS). Seafood and the omega-3 FAs intakes of pregnant women has been quantified by using a validated (FFQ). FAs analysis of erythrocytes was carried out using the method of Folch et al.

Results

Maternal depression and anxiety symptoms (30.5 % and 26.1 %) were associated with low fish consumption and omega-3 FAs intake with depressive and anxiety symptoms (p = 0.01), Women with antenatal depression or anxiety symptoms had a lower erythrocyte concentration of arachidonic acid (20:4 n-6), (p = 0.01), total omega 6 FAs, (p = 0.03), docosahexaenoic acid (22:6 n-3) (p = 0.03), docosapentaenoic acid (22:5 n-3) (p = 0.04), eicosapentaenoic acid (20:5 n-3) (p = 0.005), total omega 3 FAs (p = 0.005), omega-3 index (p = 0.01), compared to healthy pregnant women. These findings did not change after adjusting for potential confounders.

Conclusions

Maternal omega-3 FAs exert a favourable effect on vital perinatal health outcomes. Fish and seafood intake or omega-3 FAs supplementation are highly recommended for women during pregnancy to ensure the well-being of both the mother and fetus.

孕妇孕期及产后抑郁是一个全球关注的问题。孕期妇女低omega-3脂肪酸水平和摄入量与高产妇抑郁率和不良妊娠结局有关。该研究调查了阿曼讲阿拉伯语的孕妇中FAs摄入量和水平与产前抑郁和焦虑症状之间的关系。方法对302名阿曼孕妇在怀孕8-12周和24-28周时的抑郁和焦虑水平进行评估，采用阿拉伯语版（EPDS）。孕妇的海产品和omega-3脂肪酸的摄入量已经通过使用一个有效的（FFQ）进行了量化。结果母亲抑郁和焦虑症状（30.5%和26.1%）与低鱼摄入量和omega-3脂肪酸摄入与抑郁和焦虑症状相关（p = 0.01），产前抑郁或焦虑症状的妇女红细胞花生四烯酸浓度（20:4 n-6）（p = 0.01）、总omega- 6脂肪酸（p = 0.03）、二十二碳六烯酸（22:6 n-3）（p = 0.03）较低。二十二碳五烯酸（22:5 n-3）（p = 0.04）、二十碳五烯酸（20:5 n-3）（p = 0.005）、总omega-3 FAs （p = 0.005）、omega-3指数（p = 0.01）。在调整了潜在的混杂因素后，这些发现没有改变。结论母体omega-3脂肪酸对围产期重要健康结局有有利影响。强烈建议妇女在怀孕期间摄入鱼类和海鲜或补充omega-3脂肪酸，以确保母亲和胎儿的健康。

{"title":"Depression and anxiety in the pregnant Omani population in relation to their fatty acid intake and levels","authors":"Mohammed Al Sinani , Mark Johnson , Michael Crawford , Mohammed Al Maqbali , Samir Al-Adawi","doi":"10.1016/j.plefa.2025.102668","DOIUrl":"10.1016/j.plefa.2025.102668","url":null,"abstract":"<div><h3>Introduction</h3><div>Maternal depression during and after pregnancy is a worldwide public concern. Low omega-3 FAs levels and intake in women during pregnancy were associated with a high rate of maternal depression and poor pregnancy outcomes. The study examines the association between FAs intake and levels and prenatal depressive and anxiety symptoms among pregnant Arabic-speaking women in Oman.</div></div><div><h3>Methodology</h3><div>In 302 pregnant Omani women, level of depression and anxiety is assessed at the 8–12 and 24–28 weeks of pregnancy using the Arabic version of (EPDS). Seafood and the omega-3 FAs intakes of pregnant women has been quantified by using a validated (FFQ). FAs analysis of erythrocytes was carried out using the method of Folch et al.</div></div><div><h3>Results</h3><div>Maternal depression and anxiety symptoms (30.5 % and 26.1 %) were associated with low fish consumption and omega-3 FAs intake with depressive and anxiety symptoms (<em>p</em> = 0.01), Women with antenatal depression or anxiety symptoms had a lower erythrocyte concentration of arachidonic acid (20:4 n-6), (<em>p</em> = 0.01), total omega 6 FAs, (<em>p</em> = 0.03), docosahexaenoic acid (22:6 n-3) (<em>p</em> = 0.03), docosapentaenoic acid (22:5 n-3) (<em>p</em> = 0.04), eicosapentaenoic acid (20:5 n-3) (<em>p</em> = 0.005), total omega 3 FAs (<em>p</em> = 0.005), omega-3 index (<em>p</em> = 0.01), compared to healthy pregnant women. These findings did not change after adjusting for potential confounders.</div></div><div><h3>Conclusions</h3><div>Maternal omega-3 FAs exert a favourable effect on vital perinatal health outcomes. Fish and seafood intake or omega-3 FAs supplementation are highly recommended for women during pregnancy to ensure the well-being of both the mother and fetus.</div></div>","PeriodicalId":94179,"journal":{"name":"Prostaglandins, leukotrienes, and essential fatty acids","volume":"204 ","pages":"Article 102668"},"PeriodicalIF":3.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143144375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-chain omega-3 polyunsaturated fatty acids are associated with brain connectivity and mood in young adults with subthreshold depression: A preliminary study 长链omega-3多不饱和脂肪酸与年轻人阈下抑郁症的大脑连通性和情绪有关：一项初步研究。

IF 3

Prostaglandins, leukotrienes, and essential fatty acids

Pub Date : 2025-01-16 DOI: 10.1016/j.plefa.2025.102664

Paul Faulkner , E.Leigh Gibson , Simon C. Dyall

Background

The long-chain omega-3 polyunsaturated fatty acids (PUFAs) docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) have beneficial effects in depression, and these effects may be mediated via changes in functional brain connectivity. However, little is known about these effects in those with subthreshold depression.

Methods

15 Participants aged 18–29 years with Patient Health Questionnaire-8 (PHQ-8) scores ≥ 4 and Generalised Anxiety Disorder Assessment-7 (GAD-7) scores ≥ 5, underwent resting-state functional magnetic resonance imaging. Whole-brain, seed-based connectivity analyses were performed using bilateral orbitofrontal cortex (OFC) and amygdala seeds. Omega-3 and -6 PUFA status was assessed from dried bloodspot analysis of %DHA, %EPA, Omega-3 Index (calculated as the sum of DHA plus EPA expressed as a percentage of the total measured fatty acids and a correction applied as dried blood spot samples were used instead of erythrocytes) and ratio of the omega-6 PUFA arachidonic acid (ARA) to EPA (ARA/EPA).

Results

PHQ-8 scores indicated subthreshold depression (mean = 10.0; SD = 4.2) and were negatively associated with DHA levels and Omega-3 Index. Significant negative associations were also identified between connectivity of the OFC with the angular gyrus and DHA and Omega-3 Index, while weaker connectivity of these regions was associated with lower PHQ-8 and GAD-7 scores. DHA and Omega-3 Index values were significantly associated with greater connectivity of the amygdala with the posterior cingulate cortex, which was also associated with lower PHQ-8 scores.

Conclusions

Higher omega-3 PUFA status in young adults with moderate, but mean subthreshold depression was associated with lower depression rating scores and altered functional connectivity of brain regions shown to play a role in the neurobiology of depression.

背景：长链omega-3多不饱和脂肪酸（PUFAs）二十二碳六烯酸（DHA）和二十碳五烯酸（EPA）对抑郁症有有益作用，这些作用可能是通过大脑功能连接的改变来介导的。然而，对于阈下抑郁症患者的这些影响知之甚少。方法：年龄18-29岁，患者健康问卷-8 （PHQ-8）评分≥4分，广泛性焦虑障碍评估-7 （GAD-7）评分≥5分的15名参与者进行静息状态功能磁共振成像。使用双侧眶额皮质（OFC）和杏仁核种子进行全脑、基于种子的连通性分析。Omega-3和-6 PUFA状态通过对%DHA、%EPA、Omega-3指数（计算为DHA加EPA占总测量脂肪酸的百分比的总和，并在使用干血斑样品代替红细胞时进行校正）和omega-6 PUFA花生四烯酸（ARA）与EPA的比值（ARA/EPA）进行评估。结果：PHQ-8评分提示阈下抑郁(均值= 10.0；SD = 4.2)，与DHA水平和Omega-3指数呈负相关。OFC与角回的连通性与DHA和Omega-3指数之间也存在显著的负相关，而这些区域的连通性较弱与较低的PHQ-8和GAD-7评分相关。DHA和Omega-3指数值与杏仁核与后扣带皮层的连接性显著相关，这也与较低的PHQ-8评分相关。结论：在患有中度阈下抑郁症的年轻人中，较高的omega-3 PUFA水平与较低的抑郁评分和大脑区域功能连接的改变有关，这些功能连接在抑郁症的神经生物学中起作用。

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引用次数: 0

IF 3.2

Prostaglandins, leukotrienes, and essential fatty acids

Pub Date : 2025-01-01

引用次数: 0

IF 3.2

Prostaglandins, leukotrienes, and essential fatty acids

Pub Date : 2025-01-01

引用次数: 0

IF 3.2

Prostaglandins, leukotrienes, and essential fatty acids

Pub Date : 2025-01-01

引用次数: 0

IF 3.2

Prostaglandins, leukotrienes, and essential fatty acids

Pub Date : 2025-01-01

引用次数: 0

IF 3.2

Prostaglandins, leukotrienes, and essential fatty acids

Pub Date : 2025-01-01

引用次数: 0

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