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Biochemical Studies on “Bakanae” Fungus. Part 47 “Bakanae”真菌的生化研究。47岁的一部分
Pub Date : 2014-07-29 DOI: 10.1080/03758397.1958.10857513
H. Kitamura, N. Takahashi, Yasuo Seta, Y. Sumiki
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引用次数: 0
Biochemical Studies on “Bakanae” Fungus. Part 45 “Bakanae”真菌的生化研究。部分45
Pub Date : 2014-07-29 DOI: 10.1080/03758397.1958.10857511
Yasuo Seta, N. Takahashi, H. Kitamura, Y. Sumiki
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引用次数: 0
On the some Nitrogenous Constituents of the Leaves of Kuzu 苦豆叶中某些含氮成分的研究
Pub Date : 2014-07-29 DOI: 10.1080/03758397.1928.10856841
R. Sasaki
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引用次数: 0
Effect of Sodiumchloride in the Diet on the Occurrence of Liver Cancer 饮食中氯化钠对肝癌发生的影响
Pub Date : 2014-07-29 DOI: 10.1080/03758397.1960.10857717
T. Koyanagi, S. Miura
The high concentration of sodiumchloride content in the diet has deleterious effects both on the occurrence of liver cancer induced by p-dimethyl amino azobenzene through decreasing riboflavin concentration of liver and on the production of hypertension in rats. The effects can be largely counteracted by the simultaneous feeding of riboflavin.
饲粮中高浓度氯化钠对氨基偶氮苯通过降低肝脏核黄素浓度诱发肝癌的发生有不利影响,对高血压的产生也有不利影响。这种影响在很大程度上可以通过同时饲喂核黄素来抵消。
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引用次数: 0
On the Reversibility of Enzyme Action 论酶作用的可逆性
Pub Date : 2014-07-29 DOI: 10.1080/03758397.1928.10856844
B. Suzuki, T. Maruyama
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引用次数: 0
Biochemical Studies on “Bakanae” Fungus. Part 54 “Bakanae”真菌的生化研究。部分54
Pub Date : 2014-07-29 DOI: 10.1080/03758397.1959.10857584
H. Kitamura, N. Takahashi, Yasuo Seta, A. Kawarada, Y. Sumiki
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引用次数: 0
Biochemical Studies on “ Bakanae “ Fungus. Part 46 “Bakanae”真菌的生化研究。部分46
Pub Date : 2014-07-29 DOI: 10.1080/03758397.1958.10857512
N. Takahashi, Yasuo Seta, H. Kitamura, Y. Sumiki
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引用次数: 0
Studies on the Saponin of Soy-Bean 大豆皂苷的研究
Pub Date : 2014-07-29 DOI: 10.1080/03758397.1929.10856905
Y. Sumiki
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引用次数: 1
Natural Variations : New Resources for the Functional Genomics in Rice 自然变异:水稻功能基因组学的新资源
Pub Date : 2004-12-01 DOI: 10.1271/NOGEIKAGAKU1924.78.1160
M. Yano
Artificial mutations showing discrete phenotypes have often been used for analysis of the molecular basis of plant morphology and physiology. In contrast, although a wide range of phenotypic variation is ob served among strains or cultivars, these natural varia tions have not been well analyzed genetically because of their complex inheritance. However, recent progress in plant genome analysis has enabled us to perform comprehensive analysis of such naturally occurring variations. New tools (DNA markers) and information (sequences) have been used for the genetic dissection of complex traits into single genetic factors. Here, we demonstrate that naturally occurring variations are new resources for the functional analysis of rice genes. Flowering time (heading date) is a major determi nant of regional and seasonal adaptation of cultivated rice. Photoperiod and other environmental factors con trol heading date. A large amount of variation is observed in heading date and photoperiodic response among rice cultivars and strains, including wild rela tives. Quantitative trait locus (QTL) analyses of prog eny derived from several cross-combinations of culti vars has suggested that more than 15 loci are involved in heading date. In addition, new QTLs have been identified by genetic analysis of a cross between a cultivar and a wild relative. Nearly isogenic lines (NILs) have been developed by marker-assisted selec tion and used for the analysis of epistatic interaction among QTLs. Map-based cloning has been performed on several QTLs for photoperiodic response. We have demonstrated that Hd] is an ortholog of CO in Arabi dopsis and is involved in the promotion and inhibition of heading under short-day (SD) and long-day (LD) conditions, respectively. Hd6 is involved in inhibition under LD conditions and encodes the alpha-subunit of protein kinase CK2. Hd3a shows a high level of simi larity to Arabidopsis FT and functions as a flowering inducer. Ehdl is involved in promotion under SD conditions and encodes a B-type response regulator. Hd5 is involved in inhibition under LD conditions and encodes a putative subunit of a CCAAT-box-binding protein. Lhd4 is involved in inhibition under LD condi tions and encodes a protein with a CCT motif. We have identified several quantitative trait nucleotides (QTNs) that result in loss of function of these QTLs . However, some QTNs defining differences at the level of function remain to be clarified. Combining information from genetic and sequencing analyses has revealed that combinations of natural alleles with loss or gain of function at particular QTLs, such as Hd1, Hd5, Hd6, Ehd1, and Lhd4, seem to generate a wide range of continuous variation in photoperiodic flowering in rice. These genetic and molecular analyses have allowed us to propose a genetic pathway controlling photoperi odic flowering in rice. Identification and expression analyses of genes suggest that there are both con served and divergent features in photoperi
显示离散表型的人工突变经常被用于分析植物形态和生理的分子基础。相比之下,尽管在品系或品种之间观察到广泛的表型变异,但由于这些自然变异的遗传复杂性,尚未对其进行很好的遗传分析。然而,最近植物基因组分析的进展使我们能够对这种自然发生的变异进行全面分析。新的工具(DNA标记)和信息(序列)已被用于复杂性状的遗传解剖为单一遗传因素。在这里,我们证明了自然发生的变异是水稻基因功能分析的新资源。开花时间(抽穗日)是水稻区域适应性和季节适应性的主要决定因素。光周期和其他环境因素控制着抽穗期。水稻品种和品系(包括野生近缘品种)在抽穗期和光周期响应方面存在较大差异。对几个品种杂交组合后代的数量性状位点(QTL)分析表明,抽穗日期与15个以上的基因座有关。此外,通过一个栽培品种与一个野生近缘种的杂交遗传分析,还发现了新的qtl。近等基因系(near isogenic lines, NILs)已通过标记辅助选择得到,并用于qtl间上位互作的分析。对多个光周期响应qtl进行了图谱克隆。我们已经证明,Hd]是CO在阿拉伯芥中同源物,并分别参与短日(SD)和长日(LD)条件下的抽穗促进和抑制。Hd6参与LD条件下的抑制,并编码蛋白激酶CK2的α亚基。Hd3a显示出与拟南芥FT的高度相似性,并作为开花诱导剂发挥作用。Ehdl参与SD条件下的促进,并编码b型反应调节因子。Hd5参与LD条件下的抑制,并编码ccaat盒结合蛋白的一个推定亚基。Lhd4参与LD条件下的抑制,并编码一个具有CCT基序的蛋白质。我们已经确定了几个导致这些qtl功能丧失的数量性状核苷酸(QTNs)。然而,在功能水平上定义差异的一些qtn仍有待澄清。结合遗传和测序分析的信息表明,在特定qtl(如Hd1、Hd5、Hd6、Ehd1和Lhd4)上丧失或获得功能的天然等位基因组合,似乎在水稻的光周期开花中产生了广泛的连续变异。这些遗传和分子分析使我们提出了控制水稻光敏花的遗传途径。基因的鉴定和表达分析表明,光周期调控水稻(SD)和紫芥(LD)的开花既有保守性,也有差异性。基于标记的遗传方法也可用于分析开花时间以外的其他复杂性状。为了便于复杂性状的分析,已经建立了几个主要的定位群体,包括回交自交系和双单倍体系。目前已鉴定出几个对种子休眠、孕穗期耐寒性、种子碎粒习性、种子寿命和UV-B耐受性等性状有重要影响的qtl。标记辅助遗传方法极大地促进了自然变异中农学和科学上重要基因的开发。为了挖掘科学或农艺学上重要的等位基因,我们一直在开发新的定位群体,如染色体片段替代系。在这些细胞系中,来自供体细胞系的特定染色体片段被替换为再生细胞系的遗传背景。取代的片段覆盖了整条染色体的所有染色体。它们在遗传分析方面的潜力已在植物中得到证实。这些试验允许进行详细和可靠的QTL分析。标记辅助方法有助于我们了解水稻的多种复杂性状,包括植物形态和环境胁迫耐受性。这些方法使我们不仅能够从遗传学上识别复杂性状的基因,而且能够在分子水平上识别它们。此外,DNA标记技术的出现使得建立新的育种策略成为可能,例如标记辅助育种。这种策略需要对兴趣的复杂特征进行全面的剖析和理解。一旦我们确定了紧密连接的标记,目标qtl的NILs与
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引用次数: 1
Controlling Cellular Responses with Multivalent Ligands 用多价配体控制细胞反应
Pub Date : 2004-12-01 DOI: 10.1271/NOGEIKAGAKU1924.78.1159
L. Kiessling
Our group develops and implements synthetic meth ods that provide access to biologically active com pounds for hypothesis-driven and discovery-driven research. This important foundation of our program offers chemically-oriented researchers new opportuni ties to develop and apply their synthetic skills. Bio chemically and biologically-oriented researchers bene fit from access to unique biologically active ligands. Areas of current focus include: * Target-oriented synthesis of natural products and
我们的团队开发并实施了合成方法,为假设驱动和发现驱动的研究提供了获得生物活性化合物的途径。我们项目的这一重要基础为化学方向的研究人员提供了发展和应用他们的合成技能的新机会。生物化学和生物导向的研究人员受益于获得独特的生物活性配体。目前的重点领域包括:*以目标为导向的天然产物合成和
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引用次数: 0
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Bulletin of the Agricultural Chemical Society of Japan
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