Pub Date : 2019-11-28DOI: 10.3760/CMA.J.ISSN.1006-9801.2019.11.004
P. Huang
Objective To investigate the BRCA1 and BRCA2 gene mutations in patients with recurrent serous ovarian cancer and their clinical significances. Methods A total of 57 patients with recurrent serous ovarian cancer in the First Affiliated Hospital of Nanchang University from January 2016 to January 2018 were collected. High-throughput second-generation sequencing technology was used to detect BRCA1 and BRCA2 mutations in patients' blood. Statistical analysis was performed on the relationship between BRCA mutations and clinicopathological factors and prognosis. Results Of the 57 patients with recurrent serous ovarian cancer, 16 patients (28.07%) had BRCA mutations, among which 3 patients (5.26%) had nonsense mutations, 7 patients (12.28%) had frameshift mutations, and 7 patients (12.28%) had missense mutations. There was no significant difference in BRCA mutation rate among patients with different American Obstetrics and Gynecology Union (FIGO) stage, lymphatic metastasis, tissue differentiation and age stratification (all P > 0.05). Patients with family history of ovarian cancer or breast cancer had a higher BRCA mutation rate than patients without family history (7/12 vs. 9/45, χ2 = 5.13, P = 0.02), and patients who were sensitive to first-line platinum treatment had a higher BRCA mutation rate than those with drug resistant (16/45 vs. 0/12, P = 0.04). Patients with BRCA mutation had a lower serum CA125 level than patients with BRCA wild-type [(774±548)×103 U/L vs. (1 522±1 269)×103 U/L, t = 3.106, P = 0.003], and a longer median progression-free survival (PFS) time (20.5 months vs. 12.0 months, P = 0.01). Conclusions Serous ovarian cancer patients with BRCA mutations have higher sensitivity to platinum-based chemotherapeutic drugs and better PFS. Detection of BRCA mutations helps to judge prognosis and guide medication. Key words: Ovarian neoplasms; Recurrence; Mutation; BRCA gene
目的探讨复发性浆液性卵巢癌患者BRCA1和BRCA2基因突变及其临床意义。方法收集2016年1月至2018年1月南昌大学第一附属医院收治的复发性浆液性卵巢癌患者57例。采用高通量第二代测序技术检测患者血液中的BRCA1和BRCA2突变。统计分析BRCA突变与临床病理因素及预后的关系。结果57例复发性浆液性卵巢癌患者中，有16例(28.07%)发生BRCA突变，其中无义突变3例(5.26%)，移码突变7例(12.28%)，错义突变7例(12.28%)。不同FIGO分期、淋巴结转移、组织分化、年龄分层患者BRCA突变率差异无统计学意义(P < 0.05)。有卵巢癌或乳腺癌家族史的患者BRCA突变率高于无家族史的患者(7/12比9/45，χ2 = 5.13, P = 0.02)，一线铂类药物治疗敏感的患者BRCA突变率高于耐药患者(16/45比0/12,P = 0.04)。BRCA突变患者血清CA125水平低于BRCA野生型患者[(774±548)×103 U/L比(1 522±1 269)×103 U/L, t = 3.106, P = 0.003]，中位无进展生存期(PFS)时间更长(20.5个月比12.0个月，P = 0.01)。结论BRCA突变的浆液性卵巢癌患者对含铂类化疗药物敏感性较高，PFS较好。检测BRCA突变有助于判断预后和指导用药。关键词:卵巢肿瘤;复发;突变;BRCA基因
{"title":"Clinical analysis of BRCA mutations in patients with recurrent serous ovarian cancer","authors":"P. Huang","doi":"10.3760/CMA.J.ISSN.1006-9801.2019.11.004","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1006-9801.2019.11.004","url":null,"abstract":"Objective \u0000To investigate the BRCA1 and BRCA2 gene mutations in patients with recurrent serous ovarian cancer and their clinical significances. \u0000 \u0000 \u0000Methods \u0000A total of 57 patients with recurrent serous ovarian cancer in the First Affiliated Hospital of Nanchang University from January 2016 to January 2018 were collected. High-throughput second-generation sequencing technology was used to detect BRCA1 and BRCA2 mutations in patients' blood. Statistical analysis was performed on the relationship between BRCA mutations and clinicopathological factors and prognosis. \u0000 \u0000 \u0000Results \u0000Of the 57 patients with recurrent serous ovarian cancer, 16 patients (28.07%) had BRCA mutations, among which 3 patients (5.26%) had nonsense mutations, 7 patients (12.28%) had frameshift mutations, and 7 patients (12.28%) had missense mutations. There was no significant difference in BRCA mutation rate among patients with different American Obstetrics and Gynecology Union (FIGO) stage, lymphatic metastasis, tissue differentiation and age stratification (all P > 0.05). Patients with family history of ovarian cancer or breast cancer had a higher BRCA mutation rate than patients without family history (7/12 vs. 9/45, χ2 = 5.13, P = 0.02), and patients who were sensitive to first-line platinum treatment had a higher BRCA mutation rate than those with drug resistant (16/45 vs. 0/12, P = 0.04). Patients with BRCA mutation had a lower serum CA125 level than patients with BRCA wild-type [(774±548)×103 U/L vs. (1 522±1 269)×103 U/L, t = 3.106, P = 0.003], and a longer median progression-free survival (PFS) time (20.5 months vs. 12.0 months, P = 0.01). \u0000 \u0000 \u0000Conclusions \u0000Serous ovarian cancer patients with BRCA mutations have higher sensitivity to platinum-based chemotherapeutic drugs and better PFS. Detection of BRCA mutations helps to judge prognosis and guide medication. \u0000 \u0000 \u0000Key words: \u0000Ovarian neoplasms; Recurrence; Mutation; BRCA gene","PeriodicalId":9505,"journal":{"name":"Cancer Research and Clinic","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42242752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-28DOI: 10.3760/CMA.J.ISSN.1006-9801.2019.11.019
Xin-rui Yang
Vascular nutrition transmission is an irreplaceable factor in the process of tumor formation. Blocking or reducing the energy transmission pathway of tumor can effectively resist the development of tumor. There is a close relationship between JAK-STAT signaling pathway and angiogenesis, especially research on the relationship between this pathway and vascular endothelial growth factor (VEGF) signal has produced many results in recent years. This review summarizes the induction of angiogenesis, drug development, and the discovery of antiangiogenic targets in the JAK pathway, providing some ideas for the treatment of glioma. Key words: Glioma; Vascular endothelial growth factors; JAK-STAT; Angiogenesis
{"title":"Progress of JAK-STAT pathway in the angiogenesis of glioma","authors":"Xin-rui Yang","doi":"10.3760/CMA.J.ISSN.1006-9801.2019.11.019","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1006-9801.2019.11.019","url":null,"abstract":"Vascular nutrition transmission is an irreplaceable factor in the process of tumor formation. Blocking or reducing the energy transmission pathway of tumor can effectively resist the development of tumor. There is a close relationship between JAK-STAT signaling pathway and angiogenesis, especially research on the relationship between this pathway and vascular endothelial growth factor (VEGF) signal has produced many results in recent years. This review summarizes the induction of angiogenesis, drug development, and the discovery of antiangiogenic targets in the JAK pathway, providing some ideas for the treatment of glioma. \u0000 \u0000 \u0000Key words: \u0000Glioma; Vascular endothelial growth factors; JAK-STAT; Angiogenesis","PeriodicalId":9505,"journal":{"name":"Cancer Research and Clinic","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46110813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-28DOI: 10.3760/CMA.J.ISSN.1006-9801.2019.11.006
Lyu-Han Wang, J. Qian
Objective To investigate the effect of pelvic radiotherapy on intestinal flora, the correlation between radiation enteritis and intestinal flora, and the effect of probiotics intervention on intestinal flora and diarrhea. Methods From March to November 2018, a total of 22 patients who were admitted to the Affiliated Suzhou Hospital of Nanjing Medical University were enrolled in the study, including 5 patients with colorectal cancer, 15 patients with cervical cancer and 2 patients with endometrial carcinoma. Five patients with cervical cancer received oral administration of probiotics combined with radiotherapy. Ten healthy physical examiners were selected as the control group. The stool samples were collected from each patient before and after radiotherapy, and 16S rDNA sequencing technology was used to detect the fecal flora and analyze the effect of radiotherapy on intestinal flora. Results The main composition of intestinal flora in the stool samples of healthy control group was Firmicutes (39.86%), Bacteroidetes (37.77%), unclassified bacteria (15.96%) and Proteobacteria (5.03%), which was similar to patients, but the abundance of bacteria was significantly different. There were differences in the intestinal flora of patients before and after radiotherapy. Microbial diversity and abundance were altered after radiotherapy, especially in patients who later developed severe diarrhea. The Firmicutes/Bacteroidetes ratio was altered after radiotherapy. The abundance of Escherichia-Shigella and Fusobacterium increased after radiotherapy in patients who developed severe diarrhea. Oral administration of probiotics could alleviate the diarrhea and reduce the decline of microbial diversity and abundance. Conclusions In patients with pelvic tumors, the diversity and abundance of intestinal flora decrease after radiotherapy, especially in patients with severe diarrhea. Oral probiotics can alleviate the diarrhea. Key words: Pelvic neoplasms; Radiation enteritis; 16S rDNA; Intestinal flora; Probiotics
{"title":"Alteration of intestinal flora after radiotherapy in patients with pelvic cancer","authors":"Lyu-Han Wang, J. Qian","doi":"10.3760/CMA.J.ISSN.1006-9801.2019.11.006","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1006-9801.2019.11.006","url":null,"abstract":"Objective \u0000To investigate the effect of pelvic radiotherapy on intestinal flora, the correlation between radiation enteritis and intestinal flora, and the effect of probiotics intervention on intestinal flora and diarrhea. \u0000 \u0000 \u0000Methods \u0000From March to November 2018, a total of 22 patients who were admitted to the Affiliated Suzhou Hospital of Nanjing Medical University were enrolled in the study, including 5 patients with colorectal cancer, 15 patients with cervical cancer and 2 patients with endometrial carcinoma. Five patients with cervical cancer received oral administration of probiotics combined with radiotherapy. Ten healthy physical examiners were selected as the control group. The stool samples were collected from each patient before and after radiotherapy, and 16S rDNA sequencing technology was used to detect the fecal flora and analyze the effect of radiotherapy on intestinal flora. \u0000 \u0000 \u0000Results \u0000The main composition of intestinal flora in the stool samples of healthy control group was Firmicutes (39.86%), Bacteroidetes (37.77%), unclassified bacteria (15.96%) and Proteobacteria (5.03%), which was similar to patients, but the abundance of bacteria was significantly different. There were differences in the intestinal flora of patients before and after radiotherapy. Microbial diversity and abundance were altered after radiotherapy, especially in patients who later developed severe diarrhea. The Firmicutes/Bacteroidetes ratio was altered after radiotherapy. The abundance of Escherichia-Shigella and Fusobacterium increased after radiotherapy in patients who developed severe diarrhea. Oral administration of probiotics could alleviate the diarrhea and reduce the decline of microbial diversity and abundance. \u0000 \u0000 \u0000Conclusions \u0000In patients with pelvic tumors, the diversity and abundance of intestinal flora decrease after radiotherapy, especially in patients with severe diarrhea. Oral probiotics can alleviate the diarrhea. \u0000 \u0000 \u0000Key words: \u0000Pelvic neoplasms; Radiation enteritis; 16S rDNA; Intestinal flora; Probiotics","PeriodicalId":9505,"journal":{"name":"Cancer Research and Clinic","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45575799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective To investigate the clinical and pathological characteristics of succinate dehydrogenase (SDH) deficient gastrointestinal stromal tumors (GIST). Method: A retrospective analysis was conducted on the clinical and pathological data of 12 patients with SDH deficient GIST at the First People's Hospital of Tianmen City, Hubei Province from June 2010 to January 2016; Immunohistochemical method was used to detect SDH subunit B (SDHB), CD117, DOG-1, CD34, Desmin, smooth muscle actin (SMA), and S-100. Gene detection of c-kit exons 9, 11, 13, 17, and platelet derived growth factor receptor was performed α (PDGFR α） Exons 12 and 18, and review relevant literature. Results Nodular or lobulated tumors were more common, with a diameter of 3-7 cm; The tumor cells are mainly epithelioid, with 6 cases showing intravascular tumor thrombi. 12 cases of c-kit and PDGFRA were all wild-type in gene testing, while 12 cases of immunohistochemistry showed negative SDHB, positive expression of CD117, DOG-1, and CD34, and negative expression of SMA, desmin, and S-100 proteins. Conclusion: Combining the pathological characteristics of tumors, immunohistochemistry of SDHB protein, c-kit, and gene detection of PDGFRA can diagnose SDH deficient GIST. The biological behavior of such tumors is inert, and molecular targeted therapy has little benefit.
{"title":"Succinate dehydrogenase-deficient gastrointestinal stromal tumor: analysis of clinicopathological features of 12 cases","authors":"Lin Wang, Weiwei Li, Guowei Ma","doi":"10.3760/CMA.J.ISSN.1006-9801.2019.11.013","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1006-9801.2019.11.013","url":null,"abstract":"目的 \u0000探讨琥珀酸脱氢酶（SDH）缺陷型胃肠间质瘤（GIST）的临床病理特征。 \u0000 \u0000 \u0000方法 \u0000回顾性分析湖北省天门市第一人民医院2010年6月至2016年1月12例SDH缺陷型GIST患者的临床及病理资料；应用免疫组织化学法检测SDH亚单位B（SDHB）及CD117、DOG-1、CD34、Desmin、平滑肌肌动蛋白（SMA）和S-100，基因检测c-kit外显子第9、11、13、17号和血小板源生长因子受体α（PDGFRα）外显子第12、18号，并复习相关文献。 \u0000 \u0000 \u0000结果 \u0000结节状或分叶状肿瘤多见，直径3~7 cm；肿瘤细胞以上皮样为主，其中6例可见脉管内瘤栓。12例基因检测c-kit和PDGFRA均为野生型，免疫组织化学12例中SDHB均阴性，CD117、DOG-1、CD34均阳性表达，SMA、desmin、S-100蛋白皆阴性。 \u0000 \u0000 \u0000结论 \u0000综合肿瘤病理特征及SDHB蛋白免疫组织化学、c-kit和PDGFRA的基因检测可确诊SDH缺陷型GIST，此类肿瘤生物学行为呈惰性特征，分子靶向治疗极少获益。","PeriodicalId":9505,"journal":{"name":"Cancer Research and Clinic","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43682143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Giant small intestinal stromal tumor with torsion and bleeding: report of one case and review of literature","authors":"Zonglin Li, Yi Liu, Yifan Jiang, Sibei Ruan, Yejiang Zhou","doi":"10.3760/CMA.J.ISSN.1006-9801.2019.11.012","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1006-9801.2019.11.012","url":null,"abstract":"目的 \u0000提高对小肠间质瘤（SIST）的临床认识及诊疗能力。 \u0000 \u0000 \u0000方法 \u0000对西南医科大学附属医院2018年8月收治的1例巨大SIST扭转伴出血患者的临床资料及病理学特征进行回顾性分析，并结合相关文献进行复习。 \u0000 \u0000 \u0000结果 \u0000该例SIST患者出现急腹症并急诊手术治疗。主要原因为瘤体巨大而基底部细小、肿瘤扭转造成了肿瘤基底部撕裂出血。 \u0000 \u0000 \u0000结论 \u0000腹腔内巨大SIST扭转伴破裂出血以急腹症入院者较为罕见，该类患者具有极高的复发、转移和死亡风险，需在肿瘤R0切除的基础上联合伊马替尼靶向治疗。","PeriodicalId":9505,"journal":{"name":"Cancer Research and Clinic","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43268977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-28DOI: 10.3760/CMA.J.ISSN.1006-9801.2019.11.005
Qing-bo Liu, Z. Lyu, Lizhi Li, Zhuangzhuang Wu
Objective To discuss the efficacy of pelvic region Ⅰ-Ⅲ malignant bone tumor resection and function reconstruction. Methods A retrospective study was performed on 23 patients with pelvic malignant bone tumors who underwent limb salvage surgery in the Second Hospital of Shanxi Medical University from January 2010 to December 2018, including 12 males and 11 females, aged 19-78 years old. There were 22 cases of primary tumors, and 1 case of metastatic carcinoma. The tumor of 13 cases located in region Ⅰ, 2 cases in region Ⅱ, 5 cases in region Ⅲ, 1 case in region Ⅱ+Ⅲ, and 2 cases in region Ⅰ+Ⅱ. The surgical methods included resection + allograft, resection + pedicle screw reconstruction, resection + ipsilateral iliac bone graft reconstruction, and artificial hemipelvic replacement. The complications, outcomes, survival, and function recovery of patients were analyzed. Results None of the 23 patients died in the perioperative period. Five patients with tumor invasion region Ⅱ underwent hemipelvic replacement, and no serious complications occurred after operation; 15 patients underwent allogeneic bone graft or autologous bone graft after tumor resection, 2 of them had milder wound infection, and no serious complications were found in the others; 3 cases underwent pedicle screw reconstruction after tumor resection, and no obvious complications occurred after operation. By the end of follow-up, 12 patients died of local recurrence or lung metastases after surgery, including 4 patients who underwent hemipelvic replacement. The gait of 23 patients was changed to some extent, most of them were claudication; One patient needed to walk with two crutches. Conclusions The malignant bone tumors in the pelvic region Ⅰ and Ⅲ can achieve satisfactory postoperative results after extensive resection in the boundary of security. For pelvic region Ⅱ malignant bone tumors, the postoperative curative effect of half pelvic prosthesis reconstruction after resection in the boundary of security is acceptable. Key words: Bone neoplasms; Pelvis; Bone remodeling; Limb salvage surgery
{"title":"Evaluation of the efficacy of pelvic malignant bone tumor resection and function reconstruction","authors":"Qing-bo Liu, Z. Lyu, Lizhi Li, Zhuangzhuang Wu","doi":"10.3760/CMA.J.ISSN.1006-9801.2019.11.005","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1006-9801.2019.11.005","url":null,"abstract":"Objective \u0000To discuss the efficacy of pelvic region Ⅰ-Ⅲ malignant bone tumor resection and function reconstruction. \u0000 \u0000 \u0000Methods \u0000A retrospective study was performed on 23 patients with pelvic malignant bone tumors who underwent limb salvage surgery in the Second Hospital of Shanxi Medical University from January 2010 to December 2018, including 12 males and 11 females, aged 19-78 years old. There were 22 cases of primary tumors, and 1 case of metastatic carcinoma. The tumor of 13 cases located in region Ⅰ, 2 cases in region Ⅱ, 5 cases in region Ⅲ, 1 case in region Ⅱ+Ⅲ, and 2 cases in region Ⅰ+Ⅱ. The surgical methods included resection + allograft, resection + pedicle screw reconstruction, resection + ipsilateral iliac bone graft reconstruction, and artificial hemipelvic replacement. The complications, outcomes, survival, and function recovery of patients were analyzed. \u0000 \u0000 \u0000Results \u0000None of the 23 patients died in the perioperative period. Five patients with tumor invasion region Ⅱ underwent hemipelvic replacement, and no serious complications occurred after operation; 15 patients underwent allogeneic bone graft or autologous bone graft after tumor resection, 2 of them had milder wound infection, and no serious complications were found in the others; 3 cases underwent pedicle screw reconstruction after tumor resection, and no obvious complications occurred after operation. By the end of follow-up, 12 patients died of local recurrence or lung metastases after surgery, including 4 patients who underwent hemipelvic replacement. The gait of 23 patients was changed to some extent, most of them were claudication; One patient needed to walk with two crutches. \u0000 \u0000 \u0000Conclusions \u0000The malignant bone tumors in the pelvic region Ⅰ and Ⅲ can achieve satisfactory postoperative results after extensive resection in the boundary of security. For pelvic region Ⅱ malignant bone tumors, the postoperative curative effect of half pelvic prosthesis reconstruction after resection in the boundary of security is acceptable. \u0000 \u0000 \u0000Key words: \u0000Bone neoplasms; Pelvis; Bone remodeling; Limb salvage surgery","PeriodicalId":9505,"journal":{"name":"Cancer Research and Clinic","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49521717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-28DOI: 10.3760/CMA.J.ISSN.1006-9801.2019.11.007
Zhongguo Li, Yaoqiang Wu, Hongwei Xue
Objective To investigate the expressions of hypoxia inducible factor-1α (HIF-1α) and autophagy related protein Beclin-1 in colon cancer and their clinical significances. Methods From January 2017 to December 2018, 120 patients with colon cancer who were admitted to Dandong First Hospital were selected. The expressions of HIF-1α and Beclin-1 in colon cancer and corresponding adjacent tissues were detected by immunohistochemical SABC method. The relationship of the expressions of HIF-1α and Beclin-1 with the clinicopathological features of colon cancer patients was also discussed. The expressions of HIF-1α and Beclin-1 in 20 pairs of fresh colon cancer and paracancerous tissues were detected by Western blot. Results The results of immunohistochemistry showed that the positive expression rates of HIF-1α and Beclin-1 proteins in colon cancer tissues were significantly higher than those in paracancerous tissues [75.0% (90/120) vs. 21.7% (26/120), 60.8% (73/120) vs. 12.5% (15/120)], and the differences were statistically significant (χ 2 values were 68.343 and 60.359, both P 0.05). There was a positive correlation between the expressions of HIF-1α and Beclin-1 proteins in colon cancer (r = 0.483, P < 0.01). Conclusion The expressions of HIF-1α and Beclin-1 proteins in colon cancer tissues are significantly increased, and the interaction between them is involved in the occurrence and development of colon cancer. Key words: Colon neoplasms; Hypoxia-inducible factor 1, alpha subunit; Gene, Beclin-1; Autophagy
{"title":"Expressions of hypoxia inducible factor-1α and autophagy related protein Beclin-1 in colon cancer and their clinical significances","authors":"Zhongguo Li, Yaoqiang Wu, Hongwei Xue","doi":"10.3760/CMA.J.ISSN.1006-9801.2019.11.007","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1006-9801.2019.11.007","url":null,"abstract":"Objective \u0000To investigate the expressions of hypoxia inducible factor-1α (HIF-1α) and autophagy related protein Beclin-1 in colon cancer and their clinical significances. \u0000 \u0000 \u0000Methods \u0000From January 2017 to December 2018, 120 patients with colon cancer who were admitted to Dandong First Hospital were selected. The expressions of HIF-1α and Beclin-1 in colon cancer and corresponding adjacent tissues were detected by immunohistochemical SABC method. The relationship of the expressions of HIF-1α and Beclin-1 with the clinicopathological features of colon cancer patients was also discussed. The expressions of HIF-1α and Beclin-1 in 20 pairs of fresh colon cancer and paracancerous tissues were detected by Western blot. \u0000 \u0000 \u0000Results \u0000The results of immunohistochemistry showed that the positive expression rates of HIF-1α and Beclin-1 proteins in colon cancer tissues were significantly higher than those in paracancerous tissues [75.0% (90/120) vs. 21.7% (26/120), 60.8% (73/120) vs. 12.5% (15/120)], and the differences were statistically significant (χ 2 values were 68.343 and 60.359, both P 0.05). There was a positive correlation between the expressions of HIF-1α and Beclin-1 proteins in colon cancer (r = 0.483, P < 0.01). \u0000 \u0000 \u0000Conclusion \u0000The expressions of HIF-1α and Beclin-1 proteins in colon cancer tissues are significantly increased, and the interaction between them is involved in the occurrence and development of colon cancer. \u0000 \u0000 \u0000Key words: \u0000Colon neoplasms; Hypoxia-inducible factor 1, alpha subunit; Gene, Beclin-1; Autophagy","PeriodicalId":9505,"journal":{"name":"Cancer Research and Clinic","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49215416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-28DOI: 10.3760/CMA.J.ISSN.1006-9801.2019.11.010
Jian-zhong Cao, Yaqin Zheng, Jianting Liu, S. Lan, Chuantai He, Hegao Wang, Jiangang Zhang, F. Ma, Yuanchao Cui, Shuping Zhang, Yue-Xian Xing
Tumor radiotherapy is established on the basis of clinical oncology, radio-physics and radiobiology, and has become one of the three major therapeutic methods for malignant tumors. With the pace of socialist construction in China, the subject of radiotherapy in Shanxi province has developed from scratch and from small to large for more than 60 years. Remarkable achievements have been made in the establishment of departments, the updating of technical equipment, the increase of employees and clinical scientific research. This article reviews and summarizes the development history of tumor radiotherapy in Shanxi province. Key words: Neoplasms; Radiotherapy; Shanxi province
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Pub Date : 2019-11-28DOI: 10.3760/CMA.J.ISSN.1006-9801.2019.11.018
Bin Wu, Jun Ma, Shuai Chen
Esophageal cancer is one of the malignant tumors with the highest morbidity and mortality in China. Its early clinical symptoms are not typical, and the patients are already in the middle and late stage when they go to see the doctor. The 5-year survival rate of these patients is low and the prognosis is poor. At present, the precision medicine is gradually being applied to the field of clinical oncology. The detection of circulating tumor cells (CTC) has the advantages of non-invasive, easy to obtain specimens, reflect the overall state of the tumor, real-time monitoring, etc. The CTC detection has gradually become a hot research direction. CTC is tumor cell detached from the primary or metastatic tumors and released into the peripheral blood circulation. CTC detection can dynamically reflect the status of tumors. Combined with the latest reports at home and abroad, this paper mainly reviews the application and limitations of CTC in the field of esophageal cancer. Key words: Esophageal neoplasms; Neoplastic cells, circulating; Diagnosis; Treatment
{"title":"Progress of circulating tumor cells in the diagnosis and treatment of esophageal cancer","authors":"Bin Wu, Jun Ma, Shuai Chen","doi":"10.3760/CMA.J.ISSN.1006-9801.2019.11.018","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1006-9801.2019.11.018","url":null,"abstract":"Esophageal cancer is one of the malignant tumors with the highest morbidity and mortality in China. Its early clinical symptoms are not typical, and the patients are already in the middle and late stage when they go to see the doctor. The 5-year survival rate of these patients is low and the prognosis is poor. At present, the precision medicine is gradually being applied to the field of clinical oncology. The detection of circulating tumor cells (CTC) has the advantages of non-invasive, easy to obtain specimens, reflect the overall state of the tumor, real-time monitoring, etc. The CTC detection has gradually become a hot research direction. CTC is tumor cell detached from the primary or metastatic tumors and released into the peripheral blood circulation. CTC detection can dynamically reflect the status of tumors. Combined with the latest reports at home and abroad, this paper mainly reviews the application and limitations of CTC in the field of esophageal cancer. \u0000 \u0000 \u0000Key words: \u0000Esophageal neoplasms; Neoplastic cells, circulating; Diagnosis; Treatment","PeriodicalId":9505,"journal":{"name":"Cancer Research and Clinic","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45751349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-28DOI: 10.3760/CMA.J.ISSN.1006-9801.2019.11.003
R. Wu, Gehong Zhang, B. Zheng
Objective To observe the efficacy and safety of Brucea javanica oil injection combined with S-1 in the treatment of elderly patients with advanced gastric cancer. Methods The clinical data of 62 elderly patients with advanced gastric cancer who were admitted to Shanxi Provincial Cancer Hospital from May 2017 to May 2018 were retrospectively analyzed. Thirty-one patients in the control group treated with S-1 alone, and 31 patients in the observation group treated with S-1 combined with Brucea oil emulsion injection. The clinical efficacy, adverse reactions, immune function and quality of life of the two groups were compared. Results The total effective rates of the observation group and the control group were 70.97% (22/31) and 48.39% (15/31), respectively, and the difference was statistically significant (χ 2 = 11.889, P 0.05). The Karnofsky scores of the observation group and the control group after treatment were (92±4) points and (86±3) points, respectively, and the difference was statistically significant (t = -2.075, P = 0.042). The serum levels of interleukin-2 (IL-2) and interferon-γ in the observation group after treatment were (38±4) ng/L and (51±4) ng/L, and the levels in the control group were (31±3) ng/L and (40±4) ng/L, respectively, and the differences were statistically significant (t values were -2.097 and -2.293, both P < 0.05), and the serum levels of IL-4, IL-6 and IL-10 in the observation group after treatment were (42±5) ng/L, (34±4) ng/L and (22±2) ng/L, and the levels in the control group were (59±6) ng/L, (50±5) ng/L and (30±3) ng/L, respectively, and the differences were statistically significant (t values were 2.109, 2.867 and 4.278, all P < 0.05). There was no statistical difference in the serum levels of tumor necrosis factor-α between the observation group and the control group after treatment (t = -0.922, P = 0.360). Conclusion Compared with monotherapy of S-1, the treatment of Brucea javanica oil emulsion injection combined with S-1 can improve the clinical efficacy, reduce the incidence of adverse reactions, enhance the immune function and effectively improve the quality of life of elderly patients with advanced gastric cancer. Key words: Stomach neoplasms; Aged; S-1; Brucea javanica oil injection; Treatment outcome; Adverse reactions
目的观察鸦胆子油注射液联合S-1治疗老年晚期胃癌的疗效和安全性。方法回顾性分析2017年5月至2018年5月山西省肿瘤医院收治的62例高龄胃癌患者的临床资料。对照组31例患者单用S-1治疗，观察组31例患者联用S-1治疗。比较两组患者的临床疗效、不良反应、免疫功能及生活质量。结果观察组和对照组总有效率分别为70.97%(22/31)和48.39%(15/31)，差异有统计学意义(χ 2 = 11.889, P 0.05)。观察组与对照组治疗后Karnofsky评分分别为(92±4)分和(86±3)分，差异有统计学意义(t = -2.075, P = 0.042)。观察组治疗后血清白细胞介素-2 (IL-2)和干扰素-γ水平分别为(38±4)ng/L和(51±4)ng/L，对照组分别为(31±3)ng/L和(40±4)ng/L，差异均有统计学意义(t值分别为-2.097和-2.293,P均< 0.05);观察组治疗后血清IL-4、IL-6、IL-10水平分别为(42±5)ng/L、(34±4)ng/L和(22±2)ng/L。对照组分别为(59±6)ng/L、(50±5)ng/L、(30±3)ng/L，差异有统计学意义(t值分别为2.109、2.867、4.278,P均< 0.05)。治疗后观察组与对照组血清肿瘤坏死因子-α水平比较，差异无统计学意义(t = -0.922, P = 0.360)。结论与S-1单药治疗相比，鸦鸦油乳注射液联合S-1治疗可提高老年晚期胃癌患者的临床疗效，降低不良反应发生率，增强免疫功能，有效改善老年晚期胃癌患者的生活质量。关键词:胃肿瘤;岁的;s - 1;鸦胆子油注射液;治疗效果;不良反应
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