Objective: To observe the short-term efficacy and adverse reactions of low-dose apatinib combined with tigio in the treatment of recurrent or metastatic head and neck squamous cell carcinoma (HNSCC) after failure of platinum based regimens. Method: A retrospective analysis was conducted on 26 patients with recurrent or metastatic HNSCC who were admitted to the Second People's Hospital of Lianyungang City, Jiangsu Province from March 2017 to February 2019 due to failure of the platinum regimen. They received 250 mg/d of apatinib orally and 60 mg/m2 of tiggio daily, twice a day in the morning and evening. From day 1 to day 14, they rested for 7 days, and every 21 days was a cycle. Two cycles were completed for efficacy evaluation and adverse reactions were observed. Among the 26 patients, there were no complete remission, 4 partial remission, 16 stable disease, and 6 disease progression. The objective response rate was 15.3% (4/26), the disease control rate was 76.9% (20/26), and the median progression free survival period was 3.8 months (2.1-6.3 months). The main adverse reactions of patients were hypertension, thrombocytopenia, and fatigue. Conclusion: Low dose Apatinib combined with Tegio has a good short-term efficacy in the treatment of recurrent or metastatic HNSCC caused by platinum based regimens, and the patient's adverse reactions are tolerable, which has potential clinical promotion and application value.
{"title":"Clinical observation of low dose apatinib combined with tiggio in the treatment of recurrent or metastatic head and neck squamous carcinoma after failure of platinum-based regimen","authors":"Yan Wu, Ying-can Lu, M. Tao","doi":"10.3760/CMA.J.CN115355-20190620-00259","DOIUrl":"https://doi.org/10.3760/CMA.J.CN115355-20190620-00259","url":null,"abstract":"目的 \u0000观察低剂量阿帕替尼联合替吉奥治疗铂类方案失败复发或转移性头颈部鳞状细胞癌（HNSCC）的近期疗效及患者不良反应。 \u0000 \u0000 \u0000方法 \u0000回顾性分析江苏省连云港市第二人民医院2017年3月至2019年2月收治的26例铂类方案失败复发或转移性HNSCC患者，口服阿帕替尼250 mg/d，替吉奥每天60 mg/m2，分早晚2次口服，第1天至第14天，休息7 d，每21 d为1个周期，完成2个周期进行疗效评价，并观察患者不良反应。 \u0000 \u0000 \u0000结果 \u000026例患者中，无完全缓解，部分缓解4例，疾病稳定16例，疾病进展6例。客观缓解率为15.3%（4/26），疾病控制率为76.9%（20/26），中位无进展生存期为3.8个月（2.1~6.3个月），患者不良反应主要是高血压、血小板下降、乏力等。 \u0000 \u0000 \u0000结论 \u0000低剂量阿帕替尼联合替吉奥治疗铂类方案失败复发或转移性HNSCC近期疗效较好，患者不良反应可耐受，有潜在临床推广应用价值。","PeriodicalId":9505,"journal":{"name":"Cancer Research and Clinic","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46580089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-28DOI: 10.3760/CMA.J.CN115355-20190718-00314
Ziwei Xu, Yifei Feng, Yong Wang, Junwei Tang, Zan Fu
Objective To explore the clinical characteristics and prognosis of multiple primary colorectal carcinoma. Methods The clinical data of 42 cases of colorectal cancer admitted to the First Affiliated Hospital of Nanjing Medical University between January 2013 and December 2018 were retrospectively analyzed. The clinicopathological features, diagnosis, treatment and prognosis were summarized. Results There were 42 patients with multiple primary colorectal carcinoma, accounting for 1.20% (42/3 499) of all colorectal carcinoma patients in the same period. The main pathological type was adenocarcinoma. Among them, 32 cases were synchronous multiple primary carcinoma. And the age ranged 38-86 years old, and the median age was 66 years old. A total of 73 colorectal cancer lesions were detected, mostly located in the proximal colon, sigmoid colon and rectum. A total of 527 lymph nodes were detected, and the positive rate was 1.9% (10). Patients with positive lymph nodes accounted for 37.5% (12/32), including 27 cases of multiple primary carcinoma, 3 cases of triple primary carcinoma, 2 cases of five primary carcinoma. The 1-year and 3-year overall survival rates were 83.75% and 74.38%, respectively. There were 10 cases of metachronous multiple primary carcinoma. Patients were aged 33-86 years old. The first cancer was mostly located in the rectum and sigmoid colon, and the second cancer was mostly located in the ascending colon area. A total of 276 lymph nodes were detected, and the positive rate was 12.3% (34). The 1-year and 3-year overall survival rates were 100.00% and 66.67%, respectively. Conclusions Multiple primary colorectal cancer is not rare clinically and its distribution shows a certain regularity. More attention should be paid to improve the early diagnosis rate. Early operation is needed to improve the survival rate of patients. Key words: Colorectal neoplasms; Neoplasms, multiple primary; Clinical characteristics; Prognosis
{"title":"Clinical characteristics and prognosis of multiple primary colorectal carcinoma","authors":"Ziwei Xu, Yifei Feng, Yong Wang, Junwei Tang, Zan Fu","doi":"10.3760/CMA.J.CN115355-20190718-00314","DOIUrl":"https://doi.org/10.3760/CMA.J.CN115355-20190718-00314","url":null,"abstract":"Objective \u0000To explore the clinical characteristics and prognosis of multiple primary colorectal carcinoma. \u0000 \u0000 \u0000Methods \u0000The clinical data of 42 cases of colorectal cancer admitted to the First Affiliated Hospital of Nanjing Medical University between January 2013 and December 2018 were retrospectively analyzed. The clinicopathological features, diagnosis, treatment and prognosis were summarized. \u0000 \u0000 \u0000Results \u0000There were 42 patients with multiple primary colorectal carcinoma, accounting for 1.20% (42/3 499) of all colorectal carcinoma patients in the same period. The main pathological type was adenocarcinoma. Among them, 32 cases were synchronous multiple primary carcinoma. And the age ranged 38-86 years old, and the median age was 66 years old. A total of 73 colorectal cancer lesions were detected, mostly located in the proximal colon, sigmoid colon and rectum. A total of 527 lymph nodes were detected, and the positive rate was 1.9% (10). Patients with positive lymph nodes accounted for 37.5% (12/32), including 27 cases of multiple primary carcinoma, 3 cases of triple primary carcinoma, 2 cases of five primary carcinoma. The 1-year and 3-year overall survival rates were 83.75% and 74.38%, respectively. There were 10 cases of metachronous multiple primary carcinoma. Patients were aged 33-86 years old. The first cancer was mostly located in the rectum and sigmoid colon, and the second cancer was mostly located in the ascending colon area. A total of 276 lymph nodes were detected, and the positive rate was 12.3% (34). The 1-year and 3-year overall survival rates were 100.00% and 66.67%, respectively. \u0000 \u0000 \u0000Conclusions \u0000Multiple primary colorectal cancer is not rare clinically and its distribution shows a certain regularity. More attention should be paid to improve the early diagnosis rate. Early operation is needed to improve the survival rate of patients. \u0000 \u0000 \u0000Key words: \u0000Colorectal neoplasms; Neoplasms, multiple primary; Clinical characteristics; Prognosis","PeriodicalId":9505,"journal":{"name":"Cancer Research and Clinic","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48869689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-28DOI: 10.3760/CMA.J.CN115355-20190405-00125
Yuan Guo, Yunlong Li, Long Zhang, Zhen-Ying Du, Rui-zhong Gao, Leon Chen, Jipeng Li
Objective To investigate the risk factors of lymph node metastasis for patients with colorectal cancer in T3 and T4, and to provide a reference for clinical diagnosis and treatment. Methods The clinicopathological data of 1 112 patients with colorectal cancer in T3 and T4 who underwent radical resection of colorectal cancer in Xijing Digestive Disease Hospital from January 2008 to December 2017 were retrospectively analyzed. The correlation between lymph node metastasis status and the clinicopathological factors as well as tumor markers was analyzed. The related risk factors of lymph node metastasis were analyzed by using logistic multivariate regression analysis. Results Univariate analysis showed that there was no statistically significant difference in the incidence of lymph node metastasis among colorectal cancer patients stratified by gender, age and tumor location (all P > 0.05). The different tumor diameter [<5 cm and ≥5 cm: 37.75% (211/559), 52.26% (289/553), χ2 = 23.666, P < 0.01], general type [infiltration, ulcer, parasol, bulge: 37.04% (20/54), 47.52% (432/909), 34.33% (23/67), 69.51% (57/82), χ2 = 13.787, P = 0.003], degree of differentiation [highly-differentiated, moderately-differentiated, poorly-differentiated: 34.11% (102/299), 49.00% (317/647), 48.80% (81/166), χ2 = 19.771, P < 0.01], mismatch repair deficiency (dMMR) [yes and no: 26.34% (64/243), 50.17% (436/869), χ2 = 43.996, P < 0.01], neurological invasion [yes and no: 48.17% (421/874), 33.20% (79/238), χ2 = 16.954, P < 0.01], vascular invasion [yes and no: 79.16% (338/427), 23.65% (162/685), χ2 = 327.493, P < 0.01] and preoperative carcino-embryonic antigen (CEA) [positive (≥5 mg/ml) and negative (<5 mg/ml): 52.87% (249/471), 39.16% (251/641), χ2 = 20.162, P < 0.01] and CA199 [positive (≥35 U/ml) and negative (<35 U/ml): 59.33% (124/209), 41.64% (376/903), χ2 = 21.465, P < 0.01] had statistically significant differences in the incidence of lymph node metastasis for above stratified patients. Logistic multivariate regression analysis showed that vascular invasion and preoperative CA199-positive were independent risk factors for lymph node metastasis in patients with colorectal cancer in T3 and T4 (OR = 13.006, 95% CI 9.329-17.276, P < 0.01; OR = 2.194, 95% CI 1.513-3.181, P < 0.01), and dMMR-positive was a protective factor for lymph node metastasis (OR = 0.279, 95% CI 0.190-0.411, P < 0.01). Conclusions Vascular invasion is the main risk affecting factor for the lymph node metastasis of patients with colorectal cancer in T3 and T4. The detection of preoperative tumor marker CA199 can be used as an index to predict the lymph node metastasis of patients with colorectal cancer in T3 and T4. To a certain extent, it can provide a reference for the diagnosis and treatment of patients with colorectal cancer in T3 and T4. Key words: Colorectal neoplasms; Lymphatic metastasis; Risk factors
{"title":"Risk factors of lymph node metastasis in patients with colorectal cancer in T3 and T4","authors":"Yuan Guo, Yunlong Li, Long Zhang, Zhen-Ying Du, Rui-zhong Gao, Leon Chen, Jipeng Li","doi":"10.3760/CMA.J.CN115355-20190405-00125","DOIUrl":"https://doi.org/10.3760/CMA.J.CN115355-20190405-00125","url":null,"abstract":"Objective \u0000To investigate the risk factors of lymph node metastasis for patients with colorectal cancer in T3 and T4, and to provide a reference for clinical diagnosis and treatment. \u0000 \u0000 \u0000Methods \u0000The clinicopathological data of 1 112 patients with colorectal cancer in T3 and T4 who underwent radical resection of colorectal cancer in Xijing Digestive Disease Hospital from January 2008 to December 2017 were retrospectively analyzed. The correlation between lymph node metastasis status and the clinicopathological factors as well as tumor markers was analyzed. The related risk factors of lymph node metastasis were analyzed by using logistic multivariate regression analysis. \u0000 \u0000 \u0000Results \u0000Univariate analysis showed that there was no statistically significant difference in the incidence of lymph node metastasis among colorectal cancer patients stratified by gender, age and tumor location (all P > 0.05). The different tumor diameter [<5 cm and ≥5 cm: 37.75% (211/559), 52.26% (289/553), χ2 = 23.666, P < 0.01], general type [infiltration, ulcer, parasol, bulge: 37.04% (20/54), 47.52% (432/909), 34.33% (23/67), 69.51% (57/82), χ2 = 13.787, P = 0.003], degree of differentiation [highly-differentiated, moderately-differentiated, poorly-differentiated: 34.11% (102/299), 49.00% (317/647), 48.80% (81/166), χ2 = 19.771, P < 0.01], mismatch repair deficiency (dMMR) [yes and no: 26.34% (64/243), 50.17% (436/869), χ2 = 43.996, P < 0.01], neurological invasion [yes and no: 48.17% (421/874), 33.20% (79/238), χ2 = 16.954, P < 0.01], vascular invasion [yes and no: 79.16% (338/427), 23.65% (162/685), χ2 = 327.493, P < 0.01] and preoperative carcino-embryonic antigen (CEA) [positive (≥5 mg/ml) and negative (<5 mg/ml): 52.87% (249/471), 39.16% (251/641), χ2 = 20.162, P < 0.01] and CA199 [positive (≥35 U/ml) and negative (<35 U/ml): 59.33% (124/209), 41.64% (376/903), χ2 = 21.465, P < 0.01] had statistically significant differences in the incidence of lymph node metastasis for above stratified patients. Logistic multivariate regression analysis showed that vascular invasion and preoperative CA199-positive were independent risk factors for lymph node metastasis in patients with colorectal cancer in T3 and T4 (OR = 13.006, 95% CI 9.329-17.276, P < 0.01; OR = 2.194, 95% CI 1.513-3.181, P < 0.01), and dMMR-positive was a protective factor for lymph node metastasis (OR = 0.279, 95% CI 0.190-0.411, P < 0.01). \u0000 \u0000 \u0000Conclusions \u0000Vascular invasion is the main risk affecting factor for the lymph node metastasis of patients with colorectal cancer in T3 and T4. The detection of preoperative tumor marker CA199 can be used as an index to predict the lymph node metastasis of patients with colorectal cancer in T3 and T4. To a certain extent, it can provide a reference for the diagnosis and treatment of patients with colorectal cancer in T3 and T4. \u0000 \u0000 \u0000Key words: \u0000Colorectal neoplasms; Lymphatic metastasis; Risk factors","PeriodicalId":9505,"journal":{"name":"Cancer Research and Clinic","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49638652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective To investigate the misdiagnosis of neuroblastoma (NB) in children and analyze the causes of misdiagnosis. Method: A retrospective analysis was conducted on the clinical data of 20 children with NB admitted to Shanxi Children's Hospital from January 2014 to December 2017, and relevant literature was reviewed. Among the 20 cases of NB, 7 were confirmed by postoperative pathological biopsy, and 13 were confirmed by B-mode ultrasound, CT, or bone marrow aspiration cytology. Among them, 12 were misdiagnosed in the early diagnosis. Conclusion: Early misdiagnosis is is more common in children with NB, and diagnosis requires a combination of multiple methods, resulting in poor prognosis.
{"title":"Analysis of misdiagnosis causes of neuroblastoma in children","authors":"J. Lyu, Hong-ang Xi, Zhen-dong Shi","doi":"10.3760/CMA.J.CN115355-20190822-00375","DOIUrl":"https://doi.org/10.3760/CMA.J.CN115355-20190822-00375","url":null,"abstract":"目的 \u0000探讨儿童神经母细胞瘤（NB）误诊情况，并分析误诊原因。 \u0000 \u0000 \u0000方法 \u0000回顾性分析2014年1月至2017年12月山西省儿童医院收治的20例NB患儿临床资料，并复习相关文献。 \u0000 \u0000 \u0000结果 \u000020例NB患儿中，7例经术后病理活组织检查确诊，13例经B型超声、CT或骨髓穿刺细胞学检查确诊，其中12例在早期诊断中曾被误诊。 \u0000 \u0000 \u0000结论 \u0000儿童NB早期较易误诊，诊断需结合多种手段，预后较差。","PeriodicalId":9505,"journal":{"name":"Cancer Research and Clinic","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45076930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-28DOI: 10.3760/CMA.J.CN115355-20190924-00431
Tianlei Zhang, Hailang Sun, Yuan-qi Ji, Jia Yu, A. Wei
Objective To explore the phenomenon of spontaneous regression of optic pathway glioma in children, and to improve the understanding of optic pathway glioma. Methods The clinical data of 3 patients with spontaneous regression of optic pathway glioma in Beijing Children's Hospital of Capital Medical University from September 2012 to June 2019 were retrospectively analyzed. Results There were 2 girls and 1 boy among the 3 patients. The median age of onset was 4 months (3-5 months), the median age of tumor regression was 10 months (8-13 months), and the interval median time from onset to tumor regression was 5 months (4-10 months). One patient was accompanied with diencephalic syndrome, and the other was accompanied with disseminated metastasis. Conclusions The phenomenon of spontaneous regression of optic pathway glioma mostly occurs in the early childhood. Optic pathway glioma pediatric patients complicated with diencephalic syndrome or intracranial metastasis may have the possibility of tumor regression, but spontaneous regression does not mean that the symptoms can be completely improved. Key words: Optic pathway glioma; Child; Spontaneous regression
{"title":"Spontaneous regression of optic pathway glioma in children: report of three cases and review of literature","authors":"Tianlei Zhang, Hailang Sun, Yuan-qi Ji, Jia Yu, A. Wei","doi":"10.3760/CMA.J.CN115355-20190924-00431","DOIUrl":"https://doi.org/10.3760/CMA.J.CN115355-20190924-00431","url":null,"abstract":"Objective \u0000To explore the phenomenon of spontaneous regression of optic pathway glioma in children, and to improve the understanding of optic pathway glioma. \u0000 \u0000 \u0000Methods \u0000The clinical data of 3 patients with spontaneous regression of optic pathway glioma in Beijing Children's Hospital of Capital Medical University from September 2012 to June 2019 were retrospectively analyzed. \u0000 \u0000 \u0000Results \u0000There were 2 girls and 1 boy among the 3 patients. The median age of onset was 4 months (3-5 months), the median age of tumor regression was 10 months (8-13 months), and the interval median time from onset to tumor regression was 5 months (4-10 months). One patient was accompanied with diencephalic syndrome, and the other was accompanied with disseminated metastasis. \u0000 \u0000 \u0000Conclusions \u0000The phenomenon of spontaneous regression of optic pathway glioma mostly occurs in the early childhood. Optic pathway glioma pediatric patients complicated with diencephalic syndrome or intracranial metastasis may have the possibility of tumor regression, but spontaneous regression does not mean that the symptoms can be completely improved. \u0000 \u0000 \u0000Key words: \u0000Optic pathway glioma; Child; Spontaneous regression","PeriodicalId":9505,"journal":{"name":"Cancer Research and Clinic","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47596467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective To investigate the expressions of human epidermal growth factor receptor 2 (HER2) in recurrent patients after radical gastrectomy and its correlation with clinicopathologic features and prognosis. Methods The clinical data of 116 recurrent patients after radical gastrectomy between December 2011 and March 2019 in Fujian Cancer Hospital were retrospectively analyzed. The relationship between HER2 expression of the tissues after radical gastrectomy and clinicopathological features as well as prognosis was also analyzed. Results HER2 positive rate was 19.8% (23/116) in gastric cancer specimens of 116 patients after radical gastrectomy. HER2 positive rate in highly and moderately differentiated patients with gastric cancer was higher than that in those with poorly differentiated gastric cancer [33.3% (11/33) vs. 14.5% (12/83), χ2 = 5.292, P 0.05). HER2 expression was not associated with disease-free survival time (P > 0.05). Conclusion HER2 expression is associated with the differentiation degree of gastric cancer and the location of distant metastasis, but it can not be used as a predictor for recurrence of gastric cancer. Key words: Stomach neoplasms; Human epidermal growth factor receptor 2; Clinicopathologic features; Prognosis
{"title":"Expressions of human epidermal growth factor receptor 2 in recurrent patients after radical gastrectomy and its significance","authors":"Ling Chen, Jing Lin, Xiaojie Wang, Yu Chen, Lizhu Chen, Zengqing Guo, Jia-mi Yu","doi":"10.3760/CMA.J.CN115355-20191107-00506","DOIUrl":"https://doi.org/10.3760/CMA.J.CN115355-20191107-00506","url":null,"abstract":"Objective \u0000To investigate the expressions of human epidermal growth factor receptor 2 (HER2) in recurrent patients after radical gastrectomy and its correlation with clinicopathologic features and prognosis. \u0000 \u0000 \u0000Methods \u0000The clinical data of 116 recurrent patients after radical gastrectomy between December 2011 and March 2019 in Fujian Cancer Hospital were retrospectively analyzed. The relationship between HER2 expression of the tissues after radical gastrectomy and clinicopathological features as well as prognosis was also analyzed. \u0000 \u0000 \u0000Results \u0000HER2 positive rate was 19.8% (23/116) in gastric cancer specimens of 116 patients after radical gastrectomy. HER2 positive rate in highly and moderately differentiated patients with gastric cancer was higher than that in those with poorly differentiated gastric cancer [33.3% (11/33) vs. 14.5% (12/83), χ2 = 5.292, P 0.05). HER2 expression was not associated with disease-free survival time (P > 0.05). \u0000 \u0000 \u0000Conclusion \u0000HER2 expression is associated with the differentiation degree of gastric cancer and the location of distant metastasis, but it can not be used as a predictor for recurrence of gastric cancer. \u0000 \u0000 \u0000Key words: \u0000Stomach neoplasms; Human epidermal growth factor receptor 2; Clinicopathologic features; Prognosis","PeriodicalId":9505,"journal":{"name":"Cancer Research and Clinic","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43057705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Acute promyelocytic leukemia combined with differentiation syndrome: report of one case and review of literature","authors":"Hongyu Chen, F. Meng, Yaqin Yu, Dana Yao, Shunhua Huang, Q. Zhong","doi":"10.3760/CMA.J.CN115355-20190605-00233","DOIUrl":"https://doi.org/10.3760/CMA.J.CN115355-20190605-00233","url":null,"abstract":"目的 \u0000提高对急性早幼粒细胞白血病（APL）用维甲酸治疗前出现分化综合征（DS）的认识。 \u0000 \u0000 \u0000方法 \u0000报道1例APL患者在使用维甲酸治疗前出现DS的临床特征，并进行文献复习。 \u0000 \u0000 \u0000结果 \u0000该APL患者在使用维甲酸治疗前出现发热、胸闷、呼吸困难等临床表现，经抗感染、抗心力衰竭治疗后症状无改善，予地塞米松10 mg治疗5 d后呼吸困难等症状缓解，肺部渗出病灶明显减少，生命体征恢复正常。 \u0000 \u0000 \u0000结论 \u0000APL患者出现DS可与维甲酸治疗无关。","PeriodicalId":9505,"journal":{"name":"Cancer Research and Clinic","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48934993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective To analyze the influencing factors of prognosis of early mixed signet ring cell carcinoma (SRCC) of the stomach with signet ring cell ratio less than 50%. Methods The clinical data of 110 patients with SRCC who underwent radical resection of gastric cancer in the First People's Hospital of Ziyang from January 2014 to December 2016 were retrospectively analyzed. The postoperative pathology was confirmed as mixed SRCC of the stomach with signet ring cell ratio less than 50%. The patients were followed up, and the end point of the follow-up was all-cause death. The prognostic influencing factors of SRCC patients were analyzed. Results The median follow-up time was 32.5 months (0.9-70.0 months), with the median overall survival (OS) time of 40.0 months (7.0-61.0 months) and the 3-year OS rate of 46.5%. Kaplan-Meier survival analysis showed that the 3-year OS rate of age ≥60 years, male, upper stomach, tumor diameter ≥5 cm, invasion of the gastric wall, lymph node metastasis, and vascular invasion of mixed SRCC of the stomach patients was 34.3%, 31.1%, 30.0%, 33.3%, 40.7%, 28.9%, 37.5%, respectively, which was all lower than that of those with age <60 years old, female, lower stomach, tumor diameter <5 cm, non-invasive whole stomach wall, no lymph node metastasis, no vascular invasion (57.6%, 57.5%, 52.9%, 57.6%, 56.7%, 74.6%, 62.3%), and there was no statistically significant difference (all P < 0.05). Cox multivariate results showed that age ≥60 years old (OR = 1.225, 95% CI 1.089-3.481, P = 0.003), lymph node metastasis (OR = 1.077, 95% CI 1.059-2.674, P = 0.034), invasion of the whole stomach wall (OR = 1.342, 95% CI 1.117-7.225, P = 0.002), and vascular invasion (OR = 1.104, 95% CI 1.087-2.541, P = 0.018) were independent factors affecting OS of mixed SRCC of the stomach. Conclusion Mixed SRCC of the stomach patients with signet ring cell ratio less than 50% featured by advanced age, lymph node metastasis, invasion of the full thickness of the stomach wall, and vascular invasion have a poor prognosis. Key words: Stomach neoplasms; Carcinoma, signet ring cell; Signet ring cell ratio; Prognosis
目的探讨影响印戒细胞比例小于50%的胃早期混合性印戒细胞癌预后的因素。术后病理证实为胃混合性小细胞癌，印戒细胞比例小于50%。对患者进行随访，随访终点为全因死亡。分析影响小细胞癌患者预后的因素。结果中位随访时间为32.5个月(0.9 ~ 70.0个月)，中位总生存期(OS)为40.0个月(7.0 ~ 61.0个月)，3年OS率为46.5%。Kaplan-Meier生存分析显示，年龄≥60岁、男性、上胃、肿瘤直径≥5 cm、侵犯胃壁、淋巴结转移、血管侵犯的胃混合型SRCC患者3年OS率分别为34.3%、31.1%、30.0%、33.3%、40.7%、28.9%、37.5%，均低于年龄<60岁、女性、下胃、肿瘤直径<5 cm、全胃壁无创、无淋巴结转移、无血管侵犯的患者(57.6%)。57.5%、52.9%、57.6%、56.7%、74.6%、62.3%)，差异无统计学意义(均P < 0.05)。Cox多因素分析结果显示，年龄≥60岁(OR = 1.225, 95% CI 1.089 ~ 3.481, P = 0.003)、淋巴结转移(OR = 1.077, 95% CI 1.059 ~ 2.674, P = 0.034)、整个胃壁侵犯(OR = 1.342, 95% CI 1.117 ~ 7.225, P = 0.002)、血管侵犯(OR = 1.104, 95% CI 1.087 ~ 2.541, P = 0.018)是影响胃混合性恶性肿瘤生存期的独立因素。结论以年龄较大、淋巴结转移、侵犯胃壁全层、血管侵犯为特征的印戒细胞比例小于50%的胃患者混合性小细胞癌预后较差。关键词:胃肿瘤;癌，印戒细胞;印戒细胞比;预后
{"title":"Analysis of prognostic influencing factors of mixed signet ring cell carcinoma of the stomach","authors":"Li Liu, Huiling Zhang, Guo-Feng Chen, Chunyan Wang, Hai-jiao Chen, Shanlan Guo","doi":"10.3760/CMA.J.CN115355-20190710-00303","DOIUrl":"https://doi.org/10.3760/CMA.J.CN115355-20190710-00303","url":null,"abstract":"Objective \u0000To analyze the influencing factors of prognosis of early mixed signet ring cell carcinoma (SRCC) of the stomach with signet ring cell ratio less than 50%. \u0000 \u0000 \u0000Methods \u0000The clinical data of 110 patients with SRCC who underwent radical resection of gastric cancer in the First People's Hospital of Ziyang from January 2014 to December 2016 were retrospectively analyzed. The postoperative pathology was confirmed as mixed SRCC of the stomach with signet ring cell ratio less than 50%. The patients were followed up, and the end point of the follow-up was all-cause death. The prognostic influencing factors of SRCC patients were analyzed. \u0000 \u0000 \u0000Results \u0000The median follow-up time was 32.5 months (0.9-70.0 months), with the median overall survival (OS) time of 40.0 months (7.0-61.0 months) and the 3-year OS rate of 46.5%. Kaplan-Meier survival analysis showed that the 3-year OS rate of age ≥60 years, male, upper stomach, tumor diameter ≥5 cm, invasion of the gastric wall, lymph node metastasis, and vascular invasion of mixed SRCC of the stomach patients was 34.3%, 31.1%, 30.0%, 33.3%, 40.7%, 28.9%, 37.5%, respectively, which was all lower than that of those with age <60 years old, female, lower stomach, tumor diameter <5 cm, non-invasive whole stomach wall, no lymph node metastasis, no vascular invasion (57.6%, 57.5%, 52.9%, 57.6%, 56.7%, 74.6%, 62.3%), and there was no statistically significant difference (all P < 0.05). Cox multivariate results showed that age ≥60 years old (OR = 1.225, 95% CI 1.089-3.481, P = 0.003), lymph node metastasis (OR = 1.077, 95% CI 1.059-2.674, P = 0.034), invasion of the whole stomach wall (OR = 1.342, 95% CI 1.117-7.225, P = 0.002), and vascular invasion (OR = 1.104, 95% CI 1.087-2.541, P = 0.018) were independent factors affecting OS of mixed SRCC of the stomach. \u0000 \u0000 \u0000Conclusion \u0000Mixed SRCC of the stomach patients with signet ring cell ratio less than 50% featured by advanced age, lymph node metastasis, invasion of the full thickness of the stomach wall, and vascular invasion have a poor prognosis. \u0000 \u0000 \u0000Key words: \u0000Stomach neoplasms; Carcinoma, signet ring cell; Signet ring cell ratio; Prognosis","PeriodicalId":9505,"journal":{"name":"Cancer Research and Clinic","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48498752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-28DOI: 10.3760/CMA.J.CN115355-20190731-00334
W. Cui, Hongyin Zhu, Ye Dong, Xinning Zhang, Yu Liu, Jie Yu, Hao Yan, Zhi-gang Wei
Objective To explore the short-term efficacy of totally laparoscopy pancreatoduodenectomy (TLPD) and open pancreatoduodenectomy (OPD) in the treatment of periampullary carcinoma. Methods The clinical data of 50 patients with periampullary carcinoma in the First Hospital of Shanxi Medical University from June 2016 to March 2019 were retrospectively analyzed. According to the different surgical methods, the patients were divided into TLPD group (22 cases) and OPD group (28 cases). The perioperative and postoperative related indicators between the two groups were compared. Results Both groups had successfully received the operation. The operating time in TLPD group was longer than that in OPD group, and the difference between the two groups was statistically significant [(665±213) min vs. (447±215) min, t = -0.356, P = 0.001]. The amount of intraoperative bleeding in TLPD group was less than that in OPD group, and the difference between the two groups was statistically significant [100 ml (50-325 ml) vs. 300 ml (100-500 ml), Z = -2.230, P = 0.026]. There were no significant differences in the proportion of intraoperative blood transfusion, lymph node dissection number, resected tumor diameter, postoperative diet restriction time, postoperative extubation time, postoperative hospital stay and the incidence of postoperative complication between TLPD group and OPD group (all P > 0.05). Conclusions TLPD and OPD has a similar short-term efficacy in the treatment of periampullary carcinoma. The operating time of TLPD is longer than that of OPD, but TLPD can effectively control the intraoperative bleeding. Key words: Periampullary neoplasms; Pancreatoduodenectomy; Laparoscopy; Short-term efficacy
{"title":"Short-term efficacy comparison of totally laparoscopy and open pancreatoduodenectomy in the treatment of periampullary carcinoma","authors":"W. Cui, Hongyin Zhu, Ye Dong, Xinning Zhang, Yu Liu, Jie Yu, Hao Yan, Zhi-gang Wei","doi":"10.3760/CMA.J.CN115355-20190731-00334","DOIUrl":"https://doi.org/10.3760/CMA.J.CN115355-20190731-00334","url":null,"abstract":"Objective \u0000To explore the short-term efficacy of totally laparoscopy pancreatoduodenectomy (TLPD) and open pancreatoduodenectomy (OPD) in the treatment of periampullary carcinoma. \u0000 \u0000 \u0000Methods \u0000The clinical data of 50 patients with periampullary carcinoma in the First Hospital of Shanxi Medical University from June 2016 to March 2019 were retrospectively analyzed. According to the different surgical methods, the patients were divided into TLPD group (22 cases) and OPD group (28 cases). The perioperative and postoperative related indicators between the two groups were compared. \u0000 \u0000 \u0000Results \u0000Both groups had successfully received the operation. The operating time in TLPD group was longer than that in OPD group, and the difference between the two groups was statistically significant [(665±213) min vs. (447±215) min, t = -0.356, P = 0.001]. The amount of intraoperative bleeding in TLPD group was less than that in OPD group, and the difference between the two groups was statistically significant [100 ml (50-325 ml) vs. 300 ml (100-500 ml), Z = -2.230, P = 0.026]. There were no significant differences in the proportion of intraoperative blood transfusion, lymph node dissection number, resected tumor diameter, postoperative diet restriction time, postoperative extubation time, postoperative hospital stay and the incidence of postoperative complication between TLPD group and OPD group (all P > 0.05). \u0000 \u0000 \u0000Conclusions \u0000TLPD and OPD has a similar short-term efficacy in the treatment of periampullary carcinoma. The operating time of TLPD is longer than that of OPD, but TLPD can effectively control the intraoperative bleeding. \u0000 \u0000 \u0000Key words: \u0000Periampullary neoplasms; Pancreatoduodenectomy; Laparoscopy; Short-term efficacy","PeriodicalId":9505,"journal":{"name":"Cancer Research and Clinic","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44519786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective To investigate the clinicopathological characteristics of breast cancer with osteoclast like giant cells (COGC). Method: One COGC patient from Taizhou People's Hospital in Jiangsu Province in February 2016 and one COGC patient from Putuo District Central Hospital in Shanghai in May 2008 were collected, and their histological morphology, immune phenotype, and clinical pathological characteristics were observed. Relevant literature was reviewed. The results showed that both patients were female, aged 48 and 57 years respectively, and both sought medical attention due to painless breast masses. Under optical microscopy, the main manifestations are infiltrating cribriform carcinoma and non-specific infiltrating ductal carcinoma, with osteoclast like giant cells scattered within the tumor tissue, and varying degrees of bleeding and inflammatory cell infiltration in the stroma. Immunohistochemistry showed diffuse strong positivity of estrogen receptor (ER) and progesterone receptor (PR) in cancer cells, and CD68 positivity in osteoclast like giant cells. Conclusion: COGC is a rare tumor with a unique morphology of osteoclast like giant cells, which requires differentiation from multiple types of multinucleated giant cells. Its diagnosis and differential diagnosis need to be based on morphological characteristics and immune phenotype.
{"title":"Breast carcinoma with osteoclastic-like giant cells: a clinicopathological analysis of 2 cases","authors":"Xiaowei Zhu, Fuxing Liu, Guihong Dai, Xiaoqin Jiang, Wenchao Wang, Min Chen, Y. Yang, Hong-jie Yu","doi":"10.3760/CMA.J.ISSN.1006-9801.2020.02.011","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1006-9801.2020.02.011","url":null,"abstract":"目的 \u0000探讨伴破骨细胞样巨细胞的乳腺癌（COGC）的临床病理特征。 \u0000 \u0000 \u0000方法 \u0000收集2016年2月江苏省泰州市人民医院和2008年5月上海市普陀区中心医院COGC患者各1例，观察其组织学形态、免疫表型及临床病理特征，并复习相关文献。 \u0000 \u0000 \u0000结果 \u00002例患者均为女性，年龄分别为48岁及57岁，均因乳房无痛性肿块就诊。光学显微镜下主要表现为浸润性筛状癌及非特殊类型浸润性导管癌，破骨细胞样巨细胞散布在肿瘤组织内，间质内有不同程度的出血和炎症细胞浸润。免疫组织化学示癌细胞雌激素受体（ER）、孕激素受体（PR）弥漫强阳性，破骨细胞样巨细胞CD68阳性。 \u0000 \u0000 \u0000结论 \u0000COGC是一种罕见肿瘤，其内的破骨细胞样巨细胞形态特殊，需要与多种类型的多核巨细胞鉴别，其诊断及鉴别诊断需要依据形态学特征及免疫表型。","PeriodicalId":9505,"journal":{"name":"Cancer Research and Clinic","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45057495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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