Pub Date : 2025-12-18DOI: 10.1016/j.chest.2025.12.008
Patrick Flume, Wendy Bullington, Lily Christon, Eva Crawford, Alyssa Ditner, Karen Ellis, Christina Fiske, Kim Foil, Christina Hunt, Elisa Ignatius, Morgan Jones, Shannon Kasperbauer, Mary Kitlowski, Michelle MacDonald, Meghan Marmor, Molly Martel, Maria G. Tupayachi Ortiz, John Torrence
{"title":"Structure of a Bronchiectasis and NTM Care Center: a Position Statement by the Bronchiectasis & NTM Association","authors":"Patrick Flume, Wendy Bullington, Lily Christon, Eva Crawford, Alyssa Ditner, Karen Ellis, Christina Fiske, Kim Foil, Christina Hunt, Elisa Ignatius, Morgan Jones, Shannon Kasperbauer, Mary Kitlowski, Michelle MacDonald, Meghan Marmor, Molly Martel, Maria G. Tupayachi Ortiz, John Torrence","doi":"10.1016/j.chest.2025.12.008","DOIUrl":"https://doi.org/10.1016/j.chest.2025.12.008","url":null,"abstract":"","PeriodicalId":9782,"journal":{"name":"Chest","volume":"40 1","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145784538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-18DOI: 10.1016/j.chest.2025.12.005
Christian Strassberger, Jan Hedner, Scott A. Sands, Ding Zou, Ludger Grote
{"title":"From Pulse to Phenotype: Sleep Apnea Endotyping for Polygraphy via Oximeter-derived Autonomic Arousal","authors":"Christian Strassberger, Jan Hedner, Scott A. Sands, Ding Zou, Ludger Grote","doi":"10.1016/j.chest.2025.12.005","DOIUrl":"https://doi.org/10.1016/j.chest.2025.12.005","url":null,"abstract":"","PeriodicalId":9782,"journal":{"name":"Chest","volume":"34 1","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145784536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-18DOI: 10.1016/j.chest.2025.12.007
Caroline N. Muegge, Bohyung Min, Ali Mrad, Emily Ianazzo, Mark Hamblin, Sahil Pandya, Gregory Lee, Melissa Carroll, Kerri A. Johannson, Scott M. Matson
{"title":"Radiographic Fibrosis Extent Identifies Immunomodulatory Treatment Response in Hypersensitivity Pneumonitis","authors":"Caroline N. Muegge, Bohyung Min, Ali Mrad, Emily Ianazzo, Mark Hamblin, Sahil Pandya, Gregory Lee, Melissa Carroll, Kerri A. Johannson, Scott M. Matson","doi":"10.1016/j.chest.2025.12.007","DOIUrl":"https://doi.org/10.1016/j.chest.2025.12.007","url":null,"abstract":"","PeriodicalId":9782,"journal":{"name":"Chest","volume":"34 1","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145784537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-16DOI: 10.1016/j.chest.2025.12.004
Hooman D Poor, Elliot Eisenberg, Shyla Saini, Simone Hannah-Clark, Jimmy Zhang, Alison G Lee, Gregory Serrao, Charles Powell, Corey E Ventetuolo, Maria Padilla
{"title":"Sotatercept is Associated with Improved Lung Function in Sarcoidosis-Associated Pulmonary Hypertension.","authors":"Hooman D Poor, Elliot Eisenberg, Shyla Saini, Simone Hannah-Clark, Jimmy Zhang, Alison G Lee, Gregory Serrao, Charles Powell, Corey E Ventetuolo, Maria Padilla","doi":"10.1016/j.chest.2025.12.004","DOIUrl":"10.1016/j.chest.2025.12.004","url":null,"abstract":"","PeriodicalId":9782,"journal":{"name":"Chest","volume":" ","pages":""},"PeriodicalIF":8.6,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145780381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-16DOI: 10.1016/j.chest.2025.11.048
Logan J Harper,Robert P Baughman,Elyse E Lower,Francesco Bonella,Jeanette Boyd,W Ennis James,Chris Knoet,Filippo Martone,Ogugua N Obi,Katja Schillhorn,Jacobo Sellares,Dominique Valeyre,Karolien Verheyen,Daniel A Culver
BACKGROUNDOral corticosteroids (OCS) are recommended as first-line therapy for sarcoidosis, yet limited data describe the risk of steroid-associated adverse effects in this population.RESEARCH QUESTIONTo examine the short- and long-term effects of OCS exposure in terms of developing steroid-related comorbidities in a multinational sarcoidosis cohort.STUDY DESIGN AND METHODSAn electronic questionnaire was co-developed and translated by an international team of sarcoidosis experts and patients from the U.S. and Europe. We used inverse probability weighting to estimate the average treatment effect on the treated (ATT) adjusted for markers of disease severity. Before data collection, we prespecified two primary outcomes: (1) development of 13 steroid-associated comorbidities and (2) total weight change. Outcomes were compared across patients with OCS exposure categorized as "Current," "Past," or "Never".RESULTSWe collected self-reported questionnaires from 1937 patients with sarcoidosis representing 34 countries. In weighted analysis, Ever use of OCS (Current or Past OCS use) was associated with development of 1.3 more comorbidities (95% CI:0.8-1.9) compared to Never use. Ever use of OCS was associated with increased odds for the development of mood changes (OR 2.1, 95% CI:1.3-3.4), gastroesophageal reflux disease (GERD) (OR 2.3, 95% CI:1.3-4.1), bruising (OR 2.3, 95% CI:1.3-4.1), osteoporosis (OR 3.8, 95% CI 1.8-8.1), hyperlipidemia (OR 1.9, 95% CI:1.04-3.5), infections (OR 2.1, 95% CI:1.1-4.0), and diabetes (OR 2.7, 95% CI:1.2-6.0). Ever use of OCS was associated with 5.9 kg (95% CI:3.8-8.0 kg) greater net weight gain than Never use. The effects of OCS use were more pronounced between Ever vs. Never OCS users; and were similar between Current vs Past OCS users.INTERPRETATIONEver use of OCS was associated with multiple steroid-related comorbidities and weight gain in sarcoidosis patients. Notably, adverse effects persisted even after OCS discontinuation.
{"title":"Incidence of new comorbidities after steroid use in patients with sarcoidosis: an international cross-sectional survey.","authors":"Logan J Harper,Robert P Baughman,Elyse E Lower,Francesco Bonella,Jeanette Boyd,W Ennis James,Chris Knoet,Filippo Martone,Ogugua N Obi,Katja Schillhorn,Jacobo Sellares,Dominique Valeyre,Karolien Verheyen,Daniel A Culver","doi":"10.1016/j.chest.2025.11.048","DOIUrl":"https://doi.org/10.1016/j.chest.2025.11.048","url":null,"abstract":"BACKGROUNDOral corticosteroids (OCS) are recommended as first-line therapy for sarcoidosis, yet limited data describe the risk of steroid-associated adverse effects in this population.RESEARCH QUESTIONTo examine the short- and long-term effects of OCS exposure in terms of developing steroid-related comorbidities in a multinational sarcoidosis cohort.STUDY DESIGN AND METHODSAn electronic questionnaire was co-developed and translated by an international team of sarcoidosis experts and patients from the U.S. and Europe. We used inverse probability weighting to estimate the average treatment effect on the treated (ATT) adjusted for markers of disease severity. Before data collection, we prespecified two primary outcomes: (1) development of 13 steroid-associated comorbidities and (2) total weight change. Outcomes were compared across patients with OCS exposure categorized as \"Current,\" \"Past,\" or \"Never\".RESULTSWe collected self-reported questionnaires from 1937 patients with sarcoidosis representing 34 countries. In weighted analysis, Ever use of OCS (Current or Past OCS use) was associated with development of 1.3 more comorbidities (95% CI:0.8-1.9) compared to Never use. Ever use of OCS was associated with increased odds for the development of mood changes (OR 2.1, 95% CI:1.3-3.4), gastroesophageal reflux disease (GERD) (OR 2.3, 95% CI:1.3-4.1), bruising (OR 2.3, 95% CI:1.3-4.1), osteoporosis (OR 3.8, 95% CI 1.8-8.1), hyperlipidemia (OR 1.9, 95% CI:1.04-3.5), infections (OR 2.1, 95% CI:1.1-4.0), and diabetes (OR 2.7, 95% CI:1.2-6.0). Ever use of OCS was associated with 5.9 kg (95% CI:3.8-8.0 kg) greater net weight gain than Never use. The effects of OCS use were more pronounced between Ever vs. Never OCS users; and were similar between Current vs Past OCS users.INTERPRETATIONEver use of OCS was associated with multiple steroid-related comorbidities and weight gain in sarcoidosis patients. Notably, adverse effects persisted even after OCS discontinuation.","PeriodicalId":9782,"journal":{"name":"Chest","volume":"1 1","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145777467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-13DOI: 10.1016/j.chest.2025.11.047
Anthony J. Esposito, Kavitha C. Selvan, Carrie Richardson, Dinesh Khanna, Bradford C. Bemiss, Elana J. Bernstein, Jonathan H. Chung, Christian W. Cox, Jane E. Dematte, Christopher P. Denton, Oliver Distler, Monique E. Hinchcliff, Vanessa Smith, Mary E. Strek, John Varga, Anna-Maria Hoffmann-Vold, Elizabeth R. Volkmann
Interstitial lung disease (ILD) affects 40-60% of patients with systemic sclerosis (SSc) and represents the leading cause of death. While treatment options for SSc-ILD remain limited, randomized controlled trials (RCTs) have demonstrated the safety and efficacy of approved and unapproved therapies. However, numerous unanswered questions remain regarding SSc-ILD management, and three recently published clinical practice guidelines highlight the complexity of treating this condition. These guidelines offer distinct and sometimes contrasting views on SSc-ILD treatment, creating unique challenges for clinicians. The present review aims to synthesize evidence regarding the management of SSc-ILD with a focus on how to apply the recent guidelines into practice, beginning with screening for disease and extending to the intricate decision-making surrounding treatment.
{"title":"Systemic Sclerosis-Associated Interstitial Lung Disease: What We Know and How to Incorporate Guidelines into Clinical Practice","authors":"Anthony J. Esposito, Kavitha C. Selvan, Carrie Richardson, Dinesh Khanna, Bradford C. Bemiss, Elana J. Bernstein, Jonathan H. Chung, Christian W. Cox, Jane E. Dematte, Christopher P. Denton, Oliver Distler, Monique E. Hinchcliff, Vanessa Smith, Mary E. Strek, John Varga, Anna-Maria Hoffmann-Vold, Elizabeth R. Volkmann","doi":"10.1016/j.chest.2025.11.047","DOIUrl":"https://doi.org/10.1016/j.chest.2025.11.047","url":null,"abstract":"Interstitial lung disease (ILD) affects 40-60% of patients with systemic sclerosis (SSc) and represents the leading cause of death. While treatment options for SSc-ILD remain limited, randomized controlled trials (RCTs) have demonstrated the safety and efficacy of approved and unapproved therapies. However, numerous unanswered questions remain regarding SSc-ILD management, and three recently published clinical practice guidelines highlight the complexity of treating this condition. These guidelines offer distinct and sometimes contrasting views on SSc-ILD treatment, creating unique challenges for clinicians. The present review aims to synthesize evidence regarding the management of SSc-ILD with a focus on how to apply the recent guidelines into practice, beginning with screening for disease and extending to the intricate decision-making surrounding treatment.","PeriodicalId":9782,"journal":{"name":"Chest","volume":"23 1","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145753279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-12DOI: 10.1016/j.chest.2025.11.046
Birte Staude, Héloïse Torchin, Rolf F. Maier, Alan C. Fenton, Pierre-Henri Jarreau, Jan Mazela, Jennifer Zeitlin, Harald Ehrhardt
{"title":"Factors influencing unit-level differences in prevalence of prematurity associated bronchopulmonary dysplasia in a European cohort: an observational study","authors":"Birte Staude, Héloïse Torchin, Rolf F. Maier, Alan C. Fenton, Pierre-Henri Jarreau, Jan Mazela, Jennifer Zeitlin, Harald Ehrhardt","doi":"10.1016/j.chest.2025.11.046","DOIUrl":"https://doi.org/10.1016/j.chest.2025.11.046","url":null,"abstract":"","PeriodicalId":9782,"journal":{"name":"Chest","volume":"39 1","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145730718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-11DOI: 10.1016/j.chest.2025.12.001
Pei Yee Tiew, Jayanth Kumar Narayana, Tavleen Kaur Jaggi, Mariko Siyue Koh, Ken Cheah Hooi Lee, Ser Hon Puah, Rebecca C. Hull, Merete B. Long, Teck Boon Low, Mau Ern Poh, Francesco Blasi, Stefano Aliberti, James D. Chalmers, Fook Tim Chew, Sanjay H. Chotirmall
{"title":"Aspergillus fumigatus sensitization is associated with high-risk bronchiectasis","authors":"Pei Yee Tiew, Jayanth Kumar Narayana, Tavleen Kaur Jaggi, Mariko Siyue Koh, Ken Cheah Hooi Lee, Ser Hon Puah, Rebecca C. Hull, Merete B. Long, Teck Boon Low, Mau Ern Poh, Francesco Blasi, Stefano Aliberti, James D. Chalmers, Fook Tim Chew, Sanjay H. Chotirmall","doi":"10.1016/j.chest.2025.12.001","DOIUrl":"https://doi.org/10.1016/j.chest.2025.12.001","url":null,"abstract":"","PeriodicalId":9782,"journal":{"name":"Chest","volume":"150 1","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145732199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-11DOI: 10.1016/j.chest.2025.12.003
Hyun Seok Kwak, Junghee Lee, Chang-Min Choi, Young Ju Jung, Hyeong Ryul Kim, Jung Hye Hwang, Jin-Young Lee, Hong Kwan Kim, Wonjun Ji
{"title":"Impact of chronic lung disease, socioeconomic status, and family history on lung cancer risk in never-smokers: a matched case–control study","authors":"Hyun Seok Kwak, Junghee Lee, Chang-Min Choi, Young Ju Jung, Hyeong Ryul Kim, Jung Hye Hwang, Jin-Young Lee, Hong Kwan Kim, Wonjun Ji","doi":"10.1016/j.chest.2025.12.003","DOIUrl":"https://doi.org/10.1016/j.chest.2025.12.003","url":null,"abstract":"","PeriodicalId":9782,"journal":{"name":"Chest","volume":"53 1","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145730721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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