Pub Date : 2023-11-18DOI: 10.22627/2072-8107-2023-22-4-48-57
A. V. Krasivskiy, O. Kovalev, O. Borisova, O. Shamsheva, A. V. Krasivskaya, O. V. Molochkova, I. Turina
Mass immunization with H. influenzae type b (Hib) vaccines has led to a sharp decrease in the incidence of invasive and non-invasive forms of Haemophilus influenza infection. H. influenzae causes a diverse spectrum of diseases from usually asymptomatic carriage to otitis, sinusitis, epiglottitis, pneumonia, endopericarditis, inflammation of the subcutaneous tissue, arthritis, and is one of the four main causative agents of bacterial meningitis. Materials and methods. In order to identify the significance of Hemophilus influenzae infection during the vaccination period, an analysis was carried out on the spread of Hemophilus influenzae infection, its clinical forms, as well as the antibiotic resistance of the pathogen. A review of domestic and foreign publications over the past 20 years was conducted in the search engines PubMed, Google Scholar, Cochrane Library and Elibrary. Results. Studies conducted in various countries show that after the start of mass immunization, H. influenzae type b is no longer the dominant serotype of the pathogen causing invasive infections in most countries. Everywhere in the world, the leading positions are occupied by cases of infection caused by non-typable serotypes of H. influenzae type a, f, b (Hia, Hif, Hib) predominate among the capsular forms. Unprotected aminopenicillins, second-generation cephalosporins, and sulfonamides are the leading classes of antibacterial drugs to which H. influenzae strains have developed resistance. A variety of clinical forms is still relevant for hemophilic infection. Bacteremia, meningitis, and pneumonia are the main clinical manifestations of invasive Haemophilus influenzae infection caused by typed and non-typed serotypes of the pathogen.
{"title":"Evolution of Haemophilus influenzae infection during the vaccination period: literature review","authors":"A. V. Krasivskiy, O. Kovalev, O. Borisova, O. Shamsheva, A. V. Krasivskaya, O. V. Molochkova, I. Turina","doi":"10.22627/2072-8107-2023-22-4-48-57","DOIUrl":"https://doi.org/10.22627/2072-8107-2023-22-4-48-57","url":null,"abstract":"Mass immunization with H. influenzae type b (Hib) vaccines has led to a sharp decrease in the incidence of invasive and non-invasive forms of Haemophilus influenza infection. H. influenzae causes a diverse spectrum of diseases from usually asymptomatic carriage to otitis, sinusitis, epiglottitis, pneumonia, endopericarditis, inflammation of the subcutaneous tissue, arthritis, and is one of the four main causative agents of bacterial meningitis. Materials and methods. In order to identify the significance of Hemophilus influenzae infection during the vaccination period, an analysis was carried out on the spread of Hemophilus influenzae infection, its clinical forms, as well as the antibiotic resistance of the pathogen. A review of domestic and foreign publications over the past 20 years was conducted in the search engines PubMed, Google Scholar, Cochrane Library and Elibrary. Results. Studies conducted in various countries show that after the start of mass immunization, H. influenzae type b is no longer the dominant serotype of the pathogen causing invasive infections in most countries. Everywhere in the world, the leading positions are occupied by cases of infection caused by non-typable serotypes of H. influenzae type a, f, b (Hia, Hif, Hib) predominate among the capsular forms. Unprotected aminopenicillins, second-generation cephalosporins, and sulfonamides are the leading classes of antibacterial drugs to which H. influenzae strains have developed resistance. A variety of clinical forms is still relevant for hemophilic infection. Bacteremia, meningitis, and pneumonia are the main clinical manifestations of invasive Haemophilus influenzae infection caused by typed and non-typed serotypes of the pathogen.","PeriodicalId":9855,"journal":{"name":"CHILDREN INFECTIONS","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139260900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-18DOI: 10.22627/2072-8107-2023-22-4-58-62
M. A. Telesh, N. Krutikova, V. Sokolovskaya
Herpes virus infections currently are urgent problem in infectology, pediatrics and therapy. The feature of these diseases is the possibility of direct and indirect effects of the virus on various organs and systems: immune, nervous, endocrine, bone, in children in particular. The aim of the work is to summarize and systematize the available data on the impact of the chronic herpes virus infection on the bone system in children. Materials and methods: analysis of relevant Russian and international literature was carried out. Results: chronic herpes virus infections have pathological effects on bone system, in particular they can increase the risk of osteoporosis. Herpes viruses are involved in the pathogenesis of systemic inflammatory diseases, such as rheumatoid arthritis. Bone complications of herpes virus infections are the relevant issues. More research is needed to understand these complications more deeply.
{"title":"The impact of chronic herpes virus infection on the bone system in children","authors":"M. A. Telesh, N. Krutikova, V. Sokolovskaya","doi":"10.22627/2072-8107-2023-22-4-58-62","DOIUrl":"https://doi.org/10.22627/2072-8107-2023-22-4-58-62","url":null,"abstract":"Herpes virus infections currently are urgent problem in infectology, pediatrics and therapy. The feature of these diseases is the possibility of direct and indirect effects of the virus on various organs and systems: immune, nervous, endocrine, bone, in children in particular. The aim of the work is to summarize and systematize the available data on the impact of the chronic herpes virus infection on the bone system in children. Materials and methods: analysis of relevant Russian and international literature was carried out. Results: chronic herpes virus infections have pathological effects on bone system, in particular they can increase the risk of osteoporosis. Herpes viruses are involved in the pathogenesis of systemic inflammatory diseases, such as rheumatoid arthritis. Bone complications of herpes virus infections are the relevant issues. More research is needed to understand these complications more deeply.","PeriodicalId":9855,"journal":{"name":"CHILDREN INFECTIONS","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139260940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-18DOI: 10.22627/2072-8107-2023-22-4-63-68
V. Sokolovskaya, A. A. Litvinova, A. V. Krikova, R. S. Kozlov
Kawasaki syndrome (SC) and multisystem inflammatory syndrome in children (MIS-C) are inflammatory conditions that are difficult for doctors to diagnose and treat. These are two different states, despite the fact that many of their features have common features. Complex pathogenetic mechanisms that cause the development of SC find their clinical expression in the defeat of a large number of functional systems of the body. The aim: demonstrating the difficulty of diagnosing Kawasaki syndrome in a young child of 8 months. Results. The emphasis is placed on the clinical predominance of intoxication-febrile, respiratory, intestinal, exanthemic syndromes, as well as on the absence of specific symptoms from the cardiovascular system in the early stages of the disease, which made early diagnosis difficult. Conclusion. The clinical case we have presented demonstrates the atypical development of Kawasaki syndrome with a prolonged absence of changes from the cardiovascular system
{"title":"Kawasaki syndrome in a young child: clinical case","authors":"V. Sokolovskaya, A. A. Litvinova, A. V. Krikova, R. S. Kozlov","doi":"10.22627/2072-8107-2023-22-4-63-68","DOIUrl":"https://doi.org/10.22627/2072-8107-2023-22-4-63-68","url":null,"abstract":"Kawasaki syndrome (SC) and multisystem inflammatory syndrome in children (MIS-C) are inflammatory conditions that are difficult for doctors to diagnose and treat. These are two different states, despite the fact that many of their features have common features. Complex pathogenetic mechanisms that cause the development of SC find their clinical expression in the defeat of a large number of functional systems of the body. The aim: demonstrating the difficulty of diagnosing Kawasaki syndrome in a young child of 8 months. Results. The emphasis is placed on the clinical predominance of intoxication-febrile, respiratory, intestinal, exanthemic syndromes, as well as on the absence of specific symptoms from the cardiovascular system in the early stages of the disease, which made early diagnosis difficult. Conclusion. The clinical case we have presented demonstrates the atypical development of Kawasaki syndrome with a prolonged absence of changes from the cardiovascular system","PeriodicalId":9855,"journal":{"name":"CHILDREN INFECTIONS","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139261363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-18DOI: 10.22627/2072-8107-2023-22-4-69-72
V. F. Balikin
The article presents the history of the development of the Department of Children's Infectious Diseases named after Professor S.D. Nosov of the Ivanovo State Medical Academy. The department was created in 1943 on the basis of the 2nd infectious diseases building of the First City Clinical Hospital in Ivanovo. For 80 years, the staff of the department has preserved and continued the scientific and pedagogical traditions in training qualified personnel for Russian healthcare and preserving the health of children.
{"title":"80 years of protecting children's health (to the anniversary of the formation and development of the Department of Children's Infectious Diseases named after Professor S. D. Nosov of the Ivanovo State Medical Academy)","authors":"V. F. Balikin","doi":"10.22627/2072-8107-2023-22-4-69-72","DOIUrl":"https://doi.org/10.22627/2072-8107-2023-22-4-69-72","url":null,"abstract":"The article presents the history of the development of the Department of Children's Infectious Diseases named after Professor S.D. Nosov of the Ivanovo State Medical Academy. The department was created in 1943 on the basis of the 2nd infectious diseases building of the First City Clinical Hospital in Ivanovo. For 80 years, the staff of the department has preserved and continued the scientific and pedagogical traditions in training qualified personnel for Russian healthcare and preserving the health of children.","PeriodicalId":9855,"journal":{"name":"CHILDREN INFECTIONS","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139262255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-17DOI: 10.22627/2072-8107-2023-22-4-43-47
O. Popova, Yu. V. Shvetsova, S. Bunin, I. Fedorova, S. I. Koteleva, O. G. Grechishnikova
The aim of study: аnalysis of the effectiveness of inhaled steroid therapy in patients with whooping cough.Materials and methods: 74 patients with whooping cough were observed, among whom 40 children included inhalations with Budesonide in complex therapy (main group). 34 patients in the comparison group received only basic therapy. The age structure in the main group was as follow: тhere were children under one years old 18 (47.4 ± 8.1%), 1—3 years — 7 (18.4 ± 6.3%); 4—6 years — 8 (21 ± 6.6%), 7—14 years — 7 (13.2 ± 5.5%) and comparable to the comparison group. To verify whooping cough were used the PCR method and serological diagnostic (IFA) using a test system “Ridascreen/Bordetella pertussis («R-biofarm AMG», Germany). Results: budеsonide was prescribed for a course of 5—7 days. Clinical analysis of dynamics of cough in main group showed, that a reduction in a number of attacks by the 4—5th day of budesonide was observed in majority of children (35/87.5 ± 5.2%). In the main group coughing attacks with a frequency of more than 15—25 times a day persisted for 2.7 ± 0.2 days, and in comparison group — 4.3 ± 0.2 (p < 0.001). Relief of broncho-obstructive syndrome was observed in shorter period of time, which contributes to a reduction in the average length of stay of the patient in the hospital.
{"title":"Experience of using inhaled steroid therapy in children with whooping cough","authors":"O. Popova, Yu. V. Shvetsova, S. Bunin, I. Fedorova, S. I. Koteleva, O. G. Grechishnikova","doi":"10.22627/2072-8107-2023-22-4-43-47","DOIUrl":"https://doi.org/10.22627/2072-8107-2023-22-4-43-47","url":null,"abstract":"The aim of study: аnalysis of the effectiveness of inhaled steroid therapy in patients with whooping cough.Materials and methods: 74 patients with whooping cough were observed, among whom 40 children included inhalations with Budesonide in complex therapy (main group). 34 patients in the comparison group received only basic therapy. The age structure in the main group was as follow: тhere were children under one years old 18 (47.4 ± 8.1%), 1—3 years — 7 (18.4 ± 6.3%); 4—6 years — 8 (21 ± 6.6%), 7—14 years — 7 (13.2 ± 5.5%) and comparable to the comparison group. To verify whooping cough were used the PCR method and serological diagnostic (IFA) using a test system “Ridascreen/Bordetella pertussis («R-biofarm AMG», Germany). Results: budеsonide was prescribed for a course of 5—7 days. Clinical analysis of dynamics of cough in main group showed, that a reduction in a number of attacks by the 4—5th day of budesonide was observed in majority of children (35/87.5 ± 5.2%). In the main group coughing attacks with a frequency of more than 15—25 times a day persisted for 2.7 ± 0.2 days, and in comparison group — 4.3 ± 0.2 (p < 0.001). Relief of broncho-obstructive syndrome was observed in shorter period of time, which contributes to a reduction in the average length of stay of the patient in the hospital.","PeriodicalId":9855,"journal":{"name":"CHILDREN INFECTIONS","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139263241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-17DOI: 10.22627/2072-8107-2023-22-3-5-9
L. V. Kravchenko, M. Levkovich, S. B. Berezhanskaya, A. A. Afonin, I. Krukier, O. Puzikova, I. V. Panova, D. Sozaeva, V. Popova, A. Moskovkina, N. Drukker
Objective: to develop prognostic criteria for frequent respiratory diseases in the first year of life in children with cerebral ischemia who had a cytomegalovirus infection in the neonatal period. Research methods: 73 children of the first year of life with cerebral ischemia, who underwent cytomegalovirus infection in the neonatal period, were deployed. All observed patients at the age of three months underwent a study of the population composition of peripheral blood T-lymphocytes using flow cytometry for the expression of membrane markers, taking into account the results on a Beckman Coulter Epics XL II laser flow cytometer. Typing of lymphocytes was carried out using monoclonal antibodies to differentiation clusters CD3+, CD3+CD69+, CD3+CD71+, CD3+CD95+ from Immunotech (France). The observation groups consisted of 30 children (41.1%) with frequent acute respiratory infections (4—5 episodes per year) in the first year of life and 43 people (58.9%) — children with no acute respiratory infection’sepisodes in the first-year life. Results. From the set of studied T-lymphocytes, statistically significant for the prognosis of frequent acute respiratory infections in the first year of life in children with cerebral ischemia who underwent cytomegalovirus infection in the neonatal period were found: CD3+ CD71+, CD3+ CD95+. It was revealed that in children with a reduced level of CD3+ CD71+ and an increased level of CD3+ CD95+ in blood serum at the age of 3 months, frequent acute respiratory infections occurred in the first year of life.
目的：制定新生儿期感染过巨细胞病毒的脑缺血患儿出生后第一年呼吸道常见疾病的预后标准。研究方法：选取新生儿期感染过巨细胞病毒的 73 名脑缺血患儿作为研究对象。所有被观察的患者在三个月大时都接受了外周血 T 淋巴细胞群体组成研究，使用流式细胞仪检测膜标记物的表达，同时考虑贝克曼库尔特 Epics XL II 激光流式细胞仪的检测结果。使用法国 Immunotech 公司生产的分化群 CD3+、CD3+CD69+、CD3+CD71+、CD3+CD95+ 单克隆抗体对淋巴细胞进行分型。观察组中有30名儿童（41.1%）在出生后第一年经常出现急性呼吸道感染（每年4-5次），另有43名儿童（58.9%）在出生后第一年没有出现急性呼吸道感染。研究结果从研究的一组 T 淋巴细胞中发现，在新生儿期感染过巨细胞病毒的脑缺血患儿在出生后第一年频繁发生急性呼吸道感染的预后具有统计学意义：CD3+ CD71+、CD3+ CD95+。研究发现，3 个月大时血清中 CD3+ CD71+ 水平降低、CD3+ CD95+ 水平升高的患儿，在出生后第一年会频繁发生急性呼吸道感染。
{"title":"Prediction of frequent acute respiratory infections in the first year of life in children with cerebral ischemia, survivors of cytomegalovirus infection in the neonatal period","authors":"L. V. Kravchenko, M. Levkovich, S. B. Berezhanskaya, A. A. Afonin, I. Krukier, O. Puzikova, I. V. Panova, D. Sozaeva, V. Popova, A. Moskovkina, N. Drukker","doi":"10.22627/2072-8107-2023-22-3-5-9","DOIUrl":"https://doi.org/10.22627/2072-8107-2023-22-3-5-9","url":null,"abstract":"Objective: to develop prognostic criteria for frequent respiratory diseases in the first year of life in children with cerebral ischemia who had a cytomegalovirus infection in the neonatal period. Research methods: 73 children of the first year of life with cerebral ischemia, who underwent cytomegalovirus infection in the neonatal period, were deployed. All observed patients at the age of three months underwent a study of the population composition of peripheral blood T-lymphocytes using flow cytometry for the expression of membrane markers, taking into account the results on a Beckman Coulter Epics XL II laser flow cytometer. Typing of lymphocytes was carried out using monoclonal antibodies to differentiation clusters CD3+, CD3+CD69+, CD3+CD71+, CD3+CD95+ from Immunotech (France). The observation groups consisted of 30 children (41.1%) with frequent acute respiratory infections (4—5 episodes per year) in the first year of life and 43 people (58.9%) — children with no acute respiratory infection’sepisodes in the first-year life. Results. From the set of studied T-lymphocytes, statistically significant for the prognosis of frequent acute respiratory infections in the first year of life in children with cerebral ischemia who underwent cytomegalovirus infection in the neonatal period were found: CD3+ CD71+, CD3+ CD95+. It was revealed that in children with a reduced level of CD3+ CD71+ and an increased level of CD3+ CD95+ in blood serum at the age of 3 months, frequent acute respiratory infections occurred in the first year of life.","PeriodicalId":9855,"journal":{"name":"CHILDREN INFECTIONS","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139264948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-17DOI: 10.22627/2072-8107-2023-22-3-20-27
О. М. Olenkova, О. Р. Kovtun, Y. Beikin, А. S. Sokolova
The purpose of the study is to establish the clinical and immunological characteristics of COVID-19 in children and to assess the state of the immune system in the long-term period after the infection. Materials and methods. An observational cohort retrospective study was conducted, which included the results of an examination of 87 children with confirmed new coronavirus infection (COVID-19). All patients underwent laboratory examination to assess the state of the immune system at the onset of the disease and 152 ± 11.57 days after the onset of the disease. The control groups consisted of practically healthy children 8—14 (n = 26) and 15—18 years old (n = 33), who had no history of coronavirus infection, which was verified by serological tests. Results. Of the sick people, 72.2% were boys (p < 0.001). The clinical picture of COVID-19 was determined by the presence of intoxication and respiratory syndromes. The main signs were fever, unproductive cough, nasal discharge, pain and/or sore throat. In 35.2% of cases, children had concomitant pathology. At the onset of the disease in patients aged 8—14 years, a decrease in the number of neutrophils (p < 0.001) and their absorption activity (p = 0.01), an increased level of CD3+HLA-DR+ (p < 0.001), and a low level of serum IgM were detected (p < 0.001), were detected the presence of specific IgM to SARS-CoV-2; high content of Circulating immune complexes (p < 0.001). In children aged 15—18 years, an increase in the content of CD3+HLA-DR+ (p < 0.001), TNK-cells (p < 0.05), and a decreased level of total serum IgM and IgG (p < 0.001) were detected. In the long-term period after infection, in patients 8—14 years old, the changes identified at the onset of the disease persist, and there is also a decrease in the number of monocytes (p < 0.05) and an increase in the level of B-lymphocytes (p < 0.05). In the group of 15—18 years old, there was an increase in the bactericidal activity of leukocytes (p = 0.03) and the absorption activity of monocytes (p < 0.01). Conclusion. The disease proceeded mainly in a moderate form. At the initial stage of the new coronavirus infection, there was a deficiency of the humoral component, and in children of early school age, a deficiency of innate immune factors. In the long-term period, deviations in immunogram parameters persist. There is a possibility of the formation of risk groups among children for immune deficiency, which requires additional monitoring and rehabilitation measures.
{"title":"Comparative clinical and immunological characteristics of the course of the new coronavirus infection COVID-19 in children of different ages in acute and long-term periods after illness","authors":"О. М. Olenkova, О. Р. Kovtun, Y. Beikin, А. S. Sokolova","doi":"10.22627/2072-8107-2023-22-3-20-27","DOIUrl":"https://doi.org/10.22627/2072-8107-2023-22-3-20-27","url":null,"abstract":"The purpose of the study is to establish the clinical and immunological characteristics of COVID-19 in children and to assess the state of the immune system in the long-term period after the infection. Materials and methods. An observational cohort retrospective study was conducted, which included the results of an examination of 87 children with confirmed new coronavirus infection (COVID-19). All patients underwent laboratory examination to assess the state of the immune system at the onset of the disease and 152 ± 11.57 days after the onset of the disease. The control groups consisted of practically healthy children 8—14 (n = 26) and 15—18 years old (n = 33), who had no history of coronavirus infection, which was verified by serological tests. Results. Of the sick people, 72.2% were boys (p < 0.001). The clinical picture of COVID-19 was determined by the presence of intoxication and respiratory syndromes. The main signs were fever, unproductive cough, nasal discharge, pain and/or sore throat. In 35.2% of cases, children had concomitant pathology. At the onset of the disease in patients aged 8—14 years, a decrease in the number of neutrophils (p < 0.001) and their absorption activity (p = 0.01), an increased level of CD3+HLA-DR+ (p < 0.001), and a low level of serum IgM were detected (p < 0.001), were detected the presence of specific IgM to SARS-CoV-2; high content of Circulating immune complexes (p < 0.001). In children aged 15—18 years, an increase in the content of CD3+HLA-DR+ (p < 0.001), TNK-cells (p < 0.05), and a decreased level of total serum IgM and IgG (p < 0.001) were detected. In the long-term period after infection, in patients 8—14 years old, the changes identified at the onset of the disease persist, and there is also a decrease in the number of monocytes (p < 0.05) and an increase in the level of B-lymphocytes (p < 0.05). In the group of 15—18 years old, there was an increase in the bactericidal activity of leukocytes (p = 0.03) and the absorption activity of monocytes (p < 0.01). Conclusion. The disease proceeded mainly in a moderate form. At the initial stage of the new coronavirus infection, there was a deficiency of the humoral component, and in children of early school age, a deficiency of innate immune factors. In the long-term period, deviations in immunogram parameters persist. There is a possibility of the formation of risk groups among children for immune deficiency, which requires additional monitoring and rehabilitation measures.","PeriodicalId":9855,"journal":{"name":"CHILDREN INFECTIONS","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139262766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-17DOI: 10.22627/2072-8107-2023-22-4-15-19
M. Ermakova, S. N. Najdyonkina, L. P. Matveeva
Purpose: to identify clinical and laboratory aspects of a new coronavirus infection in newborns and infants. Materials and methods: a retrospective analysis of 131 observations of newborns and infants infected with SARS-CoV-2 treated in children's infectious diseases departments of Izhevsk was carried out. Results. The course of coronavirus infection in newborns and infants who became ill on an outpatient basis and were hospitalized did not have significant specific clinical and laboratory features and was similar to the symptoms of major respiratory infections. Among the hospitalized, 80.9% of children had a mild severity of coronavirus infection, the rest of the children had a moderate course. The clinical picture was dominated by cough (86.3%), nasal congestion (74%) and fever (71.8%). Significant clinical differences were obtained in newborns in the form of predominance of nasal obstruction, and in infants in the predominance of fever and dry cough. Pneumonia was diagnosed in 19.1% in the form of a mild, mainly bilateral lesion.
{"title":"Clinical and laboratory aspects of the new coronavirus infection in newborns and infants","authors":"M. Ermakova, S. N. Najdyonkina, L. P. Matveeva","doi":"10.22627/2072-8107-2023-22-4-15-19","DOIUrl":"https://doi.org/10.22627/2072-8107-2023-22-4-15-19","url":null,"abstract":"Purpose: to identify clinical and laboratory aspects of a new coronavirus infection in newborns and infants. Materials and methods: a retrospective analysis of 131 observations of newborns and infants infected with SARS-CoV-2 treated in children's infectious diseases departments of Izhevsk was carried out. Results. The course of coronavirus infection in newborns and infants who became ill on an outpatient basis and were hospitalized did not have significant specific clinical and laboratory features and was similar to the symptoms of major respiratory infections. Among the hospitalized, 80.9% of children had a mild severity of coronavirus infection, the rest of the children had a moderate course. The clinical picture was dominated by cough (86.3%), nasal congestion (74%) and fever (71.8%). Significant clinical differences were obtained in newborns in the form of predominance of nasal obstruction, and in infants in the predominance of fever and dry cough. Pneumonia was diagnosed in 19.1% in the form of a mild, mainly bilateral lesion.","PeriodicalId":9855,"journal":{"name":"CHILDREN INFECTIONS","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139266355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-17DOI: 10.22627/2072-8107-2023-22-4-28-33
E. V. Lelenkova, I. Korotkova, A. Y. Markaryan, E. Bolgarova, A. Chernysheva, P. I. Filatova, A. Semenov
Objective. Study of the viral etiology of severe acute respiratory infections (SARI) in children hospitalized in a hospital in Yekaterinburg during the epidemic season of 2022—2023. Materials and methods. 267 clinical samples (nasopharyngeal swab) obtained from children hospitalized with symptoms of acute respiratory disease were studied. The etiology of the disease was deciphered by RT-PCR, using standard sets of reagents. The material was examined for the presence of influenza A and B viruses, as well as for viruses of non-influenza etiology. 267 individual patient records were analyzed. Results. As a result, it was found that cases of SARI were more often registered among younger children, the structure of SARI of influenza etiology was represented by influenza A(H1N1)pdm09 virus — 29.9% and influenza B virus — 20.7%, while it was found that most children were not vaccinated against influenza. The proportion of viruses of non-influenza etiology was represented by RS viruses (23.0%), rhinoviruses (9.2%) and bokaviruses (6.3%).
研究目的研究叶卡捷琳堡市一家医院 2022-2023 年流行病季节住院儿童严重急性呼吸道感染（SARI）的病毒病因。材料与方法对从有急性呼吸道疾病症状的住院儿童处获得的 267 份临床样本（鼻咽拭子）进行了研究。使用标准试剂盒，通过 RT-PCR 技术破译了病原体。检查材料中是否存在甲型和乙型流感病毒以及非流感病毒。对 267 份患者病历进行了分析。结果显示结果发现，登记的 SARI 病例多见于年龄较小的儿童，流感病因的 SARI 结构以甲型 H1N1 pdm09 流感病毒为代表--占 29.9%，乙型流感病毒占 20.7%，同时发现大多数儿童未接种流感疫苗。非流感病毒的比例为 RS 病毒（23.0%）、鼻病毒（9.2%）和博卡病毒（6.3%）。
{"title":"Etiology of severe acute respiratory infections in children hospitalized in hospitals of Ekaterinburg in the epidemic season of 2022 — 2023","authors":"E. V. Lelenkova, I. Korotkova, A. Y. Markaryan, E. Bolgarova, A. Chernysheva, P. I. Filatova, A. Semenov","doi":"10.22627/2072-8107-2023-22-4-28-33","DOIUrl":"https://doi.org/10.22627/2072-8107-2023-22-4-28-33","url":null,"abstract":"Objective. Study of the viral etiology of severe acute respiratory infections (SARI) in children hospitalized in a hospital in Yekaterinburg during the epidemic season of 2022—2023. Materials and methods. 267 clinical samples (nasopharyngeal swab) obtained from children hospitalized with symptoms of acute respiratory disease were studied. The etiology of the disease was deciphered by RT-PCR, using standard sets of reagents. The material was examined for the presence of influenza A and B viruses, as well as for viruses of non-influenza etiology. 267 individual patient records were analyzed. Results. As a result, it was found that cases of SARI were more often registered among younger children, the structure of SARI of influenza etiology was represented by influenza A(H1N1)pdm09 virus — 29.9% and influenza B virus — 20.7%, while it was found that most children were not vaccinated against influenza. The proportion of viruses of non-influenza etiology was represented by RS viruses (23.0%), rhinoviruses (9.2%) and bokaviruses (6.3%).","PeriodicalId":9855,"journal":{"name":"CHILDREN INFECTIONS","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139266429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-17DOI: 10.22627/2072-8107-2023-22-4-34-38
N. S. Tian, I. Babachenko, O. Goleva, E. Orlova, N. S. Bezverkhaya, R. S. Kalinin, V. V. Tsay, E. V. Pinkovskaya, A. V. Krylov, A. Kusakin, Y. Eismont, A. Mukomolova, E. V. Baziian
Purpose: To characterize clinical and laboratory features of infectious mononucleosis (IM) of EBV and HHV-6 etiology among children. Material and methods. A single-center prospective study was performed at Pediatric Research and Clinical Center for Infectious Diseases in 2021 — 2022, which included 84 patients with IM EBV (n = 40), HHV-6 (n = 11), EBV + HHV-6 (n = 33). Methods of laboratory diagnostics were clinical, biochemical blood tests, qualitative and quantitative PCR of blood (whole blood, plasma) to herpesvirus 4—6 types. Results. Patients with EBV IM were significantly older than children with HHV-6 IM and EBV + + HHV-6 IM (р ≤ 0,004). The main complaint of patients was fever (median 39,0°С, Q1—Q3 38,5—39,3°С). Nasal stuffiness (93%), tonsillitis (86%), peripheral cervical lymphadenopathy (100%) dominated among clinical manifestations in all groups. Splenomegaly was noted more rarely than hepatomegaly in children. There were no significant differences in the level of leukocytes among patients (р > 0,05). Increased values of lymphocytes, atypical mononuclear cells, hepatic cytolysis syndrome were characteristic of EBV-monoinfection (р ≤ 0,007). On the contrary, level of neutrophils was significantly higher in the HHV-6 IM group. Genotype HHV-6B was detected in 100% of cases. Assay of EBV viral load showed following: this indicator in plasma (р = 0,0008) and whole blood (р = 0,028) in EBV patients was significantly higher than among EBV + HHV-6 IM. A direct moderate correlation was found between viral loads in different human fluids (r = 0,413, р < 0,05). Conclusions. The results emphasize the importance of clinical and etiological diagnosis, including HHV-6 determination, for the well-timed registration of children with IM and their coverage with regular medical check-up.
{"title":"Clinical, laboratory and virological aspects in infectious mononucleosis of EBV- and HHV-6 etiology in children","authors":"N. S. Tian, I. Babachenko, O. Goleva, E. Orlova, N. S. Bezverkhaya, R. S. Kalinin, V. V. Tsay, E. V. Pinkovskaya, A. V. Krylov, A. Kusakin, Y. Eismont, A. Mukomolova, E. V. Baziian","doi":"10.22627/2072-8107-2023-22-4-34-38","DOIUrl":"https://doi.org/10.22627/2072-8107-2023-22-4-34-38","url":null,"abstract":"Purpose: To characterize clinical and laboratory features of infectious mononucleosis (IM) of EBV and HHV-6 etiology among children. Material and methods. A single-center prospective study was performed at Pediatric Research and Clinical Center for Infectious Diseases in 2021 — 2022, which included 84 patients with IM EBV (n = 40), HHV-6 (n = 11), EBV + HHV-6 (n = 33). Methods of laboratory diagnostics were clinical, biochemical blood tests, qualitative and quantitative PCR of blood (whole blood, plasma) to herpesvirus 4—6 types. Results. Patients with EBV IM were significantly older than children with HHV-6 IM and EBV + + HHV-6 IM (р ≤ 0,004). The main complaint of patients was fever (median 39,0°С, Q1—Q3 38,5—39,3°С). Nasal stuffiness (93%), tonsillitis (86%), peripheral cervical lymphadenopathy (100%) dominated among clinical manifestations in all groups. Splenomegaly was noted more rarely than hepatomegaly in children. There were no significant differences in the level of leukocytes among patients (р > 0,05). Increased values of lymphocytes, atypical mononuclear cells, hepatic cytolysis syndrome were characteristic of EBV-monoinfection (р ≤ 0,007). On the contrary, level of neutrophils was significantly higher in the HHV-6 IM group. Genotype HHV-6B was detected in 100% of cases. Assay of EBV viral load showed following: this indicator in plasma (р = 0,0008) and whole blood (р = 0,028) in EBV patients was significantly higher than among EBV + HHV-6 IM. A direct moderate correlation was found between viral loads in different human fluids (r = 0,413, р < 0,05). Conclusions. The results emphasize the importance of clinical and etiological diagnosis, including HHV-6 determination, for the well-timed registration of children with IM and their coverage with regular medical check-up.","PeriodicalId":9855,"journal":{"name":"CHILDREN INFECTIONS","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139263060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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