Pub Date : 2022-11-23DOI: 10.22627/2072-8107-2022-21-4-8-14
N. Dracheva, L. Mazankova, E. Samitova, I. Osmanov, O. Klimova, O. Demina
During the COVID-19 pandemic, the combination of infections caused by SARS-Cov-2 and M. rheimopiae is the subject of increased attention of clinicians. This article presents an observation of 37 children with COVID-19 in combination with respiratory mycoplasmosis (RM), the purpose of which was to identify the features of the course of combined infections compared with monoinfections. According to the results of the study, the similarity of the clinical picture of upper and lower respiratory tract lesions in the groups of combined infections and monoinfection COVID-19 was reliably established, which requires updating the examination and treatment plan in the study cohort of children.
{"title":"Features of the course of COVID-19 in combination with respiratory mycoplasmosis in children","authors":"N. Dracheva, L. Mazankova, E. Samitova, I. Osmanov, O. Klimova, O. Demina","doi":"10.22627/2072-8107-2022-21-4-8-14","DOIUrl":"https://doi.org/10.22627/2072-8107-2022-21-4-8-14","url":null,"abstract":"During the COVID-19 pandemic, the combination of infections caused by SARS-Cov-2 and M. rheimopiae is the subject of increased attention of clinicians. This article presents an observation of 37 children with COVID-19 in combination with respiratory mycoplasmosis (RM), the purpose of which was to identify the features of the course of combined infections compared with monoinfections. According to the results of the study, the similarity of the clinical picture of upper and lower respiratory tract lesions in the groups of combined infections and monoinfection COVID-19 was reliably established, which requires updating the examination and treatment plan in the study cohort of children.","PeriodicalId":9855,"journal":{"name":"CHILDREN INFECTIONS","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74801828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-02DOI: 10.22627/2072-8107-2022-21-3-61-64
O. V. Molochkova, O. Kovalev, P. Luzan, N. Ilyina, Sh. A. Ganiev, A. Konovalov, O. Shamsheva, N. Egorova, A. D. Zotova, A. L. Rossina, A. A. Korsunskiy, E. Galeeva, A. A. Guzhavina, A. Tebenkov, V. G. Shatalov
Chickenpox is a controlled infection, even a single vaccination effectively prevents the development of severe forms (up to 98%).Purpose — to demonstrate a case of severe chicken pox in a child aged 3.8 years with secondary infection of the skin of the right subscapular region and subcutaneous fat (phlegmon of the trunk) of streptococcal etiology.The diagnosis of varicella was confirmed by the detection of Varicella-Zoster virus DNA by PCR from the skin. Surgical treatment was performed — opening and drainage of phlegmon, purulent-serous discharge was obtained, sowing was performed, Streptococcus pyogenes was isolated.The child received antibiotic therapy — cefepime sulbactam, amikacin, acyclovir, infusion therapy, local treatment.Conclusions. The given clinical case demonstrates the development of a severe bacterial complication of chicken pox, which required surgical treatment and substantiates the need for vaccination against chicken pox and its possible complications.
{"title":"A case of chickenpox with multiple bacterial complications requiring surgical treatment","authors":"O. V. Molochkova, O. Kovalev, P. Luzan, N. Ilyina, Sh. A. Ganiev, A. Konovalov, O. Shamsheva, N. Egorova, A. D. Zotova, A. L. Rossina, A. A. Korsunskiy, E. Galeeva, A. A. Guzhavina, A. Tebenkov, V. G. Shatalov","doi":"10.22627/2072-8107-2022-21-3-61-64","DOIUrl":"https://doi.org/10.22627/2072-8107-2022-21-3-61-64","url":null,"abstract":"Chickenpox is a controlled infection, even a single vaccination effectively prevents the development of severe forms (up to 98%).Purpose — to demonstrate a case of severe chicken pox in a child aged 3.8 years with secondary infection of the skin of the right subscapular region and subcutaneous fat (phlegmon of the trunk) of streptococcal etiology.The diagnosis of varicella was confirmed by the detection of Varicella-Zoster virus DNA by PCR from the skin. Surgical treatment was performed — opening and drainage of phlegmon, purulent-serous discharge was obtained, sowing was performed, Streptococcus pyogenes was isolated.The child received antibiotic therapy — cefepime sulbactam, amikacin, acyclovir, infusion therapy, local treatment.Conclusions. The given clinical case demonstrates the development of a severe bacterial complication of chicken pox, which required surgical treatment and substantiates the need for vaccination against chicken pox and its possible complications.","PeriodicalId":9855,"journal":{"name":"CHILDREN INFECTIONS","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87067479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-02DOI: 10.22627/2072-8107-2022-21-3-33-38
E. O. Kochetova, V. F. Balikin, O. Shamsheva, I. V. Polesco, V. F. Uchaykin, V. Konev, O. A. Mayorova, V. Belyakova, V. V. Gorev, L. B. Kononov
A clinical and laboratory examination of 62 children aged 10—17 years vaccinated against hepatitis B according to the standard scheme (0—1—6 months) in the first year of life strictly according to the National Calendar of preventive vaccinations in a standard dose (10 micrograms of recombinant HBsAg) with a monocomponent vaccine was carried out.The majority of children (58%) had indicators of seroconversion of HBsAg — anti-HBs-antibodies. This indicates the fact of long-lasting Grund immunity — 10—17 years after timely 3-fold immunization against hepatitis B according to the standard scheme at a standard dose (10 mcg of recombinant HBsAg in the first year of life in the absence of Wooster immunization (revaccination) in subsequent age periods, including children with a burdened premorbid background (87.1% among those observed). Since among those observed were children with invasive medical interventions (50%), the established fact reflects the protective effect of standard Grund immunization even in children at risk — with a positive parenteral history. At the same time, the total assessment of serological and molecular biological results found that after triple immunization against hepatitis B according to the standard scheme in the first year of life, out of 62 children aged 10—17 years, the proportion of seronegative was 42%. Low levels of antibodies (10—100 IU/l) were detected in 43% of cases, high (100—1000 IU/l) — in 15% of cases. No child had an antibody level exceeding >1000 IU/l. These results require the development of new approaches to immunization of children against hepatitis B with mandatory revaccination at an older age.
{"title":"Longitudinal monitoring of post-vaccination immunity against hepatitis B in children after standard immunization in the first year of life and optimization of vaccination strategy","authors":"E. O. Kochetova, V. F. Balikin, O. Shamsheva, I. V. Polesco, V. F. Uchaykin, V. Konev, O. A. Mayorova, V. Belyakova, V. V. Gorev, L. B. Kononov","doi":"10.22627/2072-8107-2022-21-3-33-38","DOIUrl":"https://doi.org/10.22627/2072-8107-2022-21-3-33-38","url":null,"abstract":"A clinical and laboratory examination of 62 children aged 10—17 years vaccinated against hepatitis B according to the standard scheme (0—1—6 months) in the first year of life strictly according to the National Calendar of preventive vaccinations in a standard dose (10 micrograms of recombinant HBsAg) with a monocomponent vaccine was carried out.The majority of children (58%) had indicators of seroconversion of HBsAg — anti-HBs-antibodies. This indicates the fact of long-lasting Grund immunity — 10—17 years after timely 3-fold immunization against hepatitis B according to the standard scheme at a standard dose (10 mcg of recombinant HBsAg in the first year of life in the absence of Wooster immunization (revaccination) in subsequent age periods, including children with a burdened premorbid background (87.1% among those observed). Since among those observed were children with invasive medical interventions (50%), the established fact reflects the protective effect of standard Grund immunization even in children at risk — with a positive parenteral history. At the same time, the total assessment of serological and molecular biological results found that after triple immunization against hepatitis B according to the standard scheme in the first year of life, out of 62 children aged 10—17 years, the proportion of seronegative was 42%. Low levels of antibodies (10—100 IU/l) were detected in 43% of cases, high (100—1000 IU/l) — in 15% of cases. No child had an antibody level exceeding >1000 IU/l. These results require the development of new approaches to immunization of children against hepatitis B with mandatory revaccination at an older age.","PeriodicalId":9855,"journal":{"name":"CHILDREN INFECTIONS","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74272104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-02DOI: 10.22627/2072-8107-2022-21-3-65-67
Ya. A. Bogvilene, G. Martynova, M. A. Stroganovа, A. A. Lapteva
Yersinia infection continues to be a significant problem in infectology due to the prevalence, polymorphism of clinical manifestations, difficulties in laboratory diagnosis, often severe and complicated course of the disease, and the possibility of adverse outcomes.The article presents a clinical case of a generalized form of yersinia infection with the development of acute renal failure in a 10-year-old child.
{"title":"Development of acute renal failure in a child with a generalized form of yersiniosis infection","authors":"Ya. A. Bogvilene, G. Martynova, M. A. Stroganovа, A. A. Lapteva","doi":"10.22627/2072-8107-2022-21-3-65-67","DOIUrl":"https://doi.org/10.22627/2072-8107-2022-21-3-65-67","url":null,"abstract":"Yersinia infection continues to be a significant problem in infectology due to the prevalence, polymorphism of clinical manifestations, difficulties in laboratory diagnosis, often severe and complicated course of the disease, and the possibility of adverse outcomes.The article presents a clinical case of a generalized form of yersinia infection with the development of acute renal failure in a 10-year-old child.","PeriodicalId":9855,"journal":{"name":"CHILDREN INFECTIONS","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80532444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-02DOI: 10.22627/2072-8107-2022-21-3-47-51
V. Sokolovskaya, A. A. Litvinova, A. V. Krikova, R. Kozlov
Numerous works of domestic and foreign colleagues have proved that obesity is an independent risk factor for severe COVID-19 among patients of all age groups. Of particular interest is the study of the effect of overweight on the course of a new coronavirus infection in children and adolescents.Objective. Demonstration of a clinical case of fatal outcome of COVID-19 in a patient with morbid obesity; analysis and generalization of current data on the effect of obesity on the course of a new coronavirus infection in pediatric patients.The article presents a general understanding of the pathogenetic relationship between the two pathologies, as well as a case of a fatal outcome of a new coronavirus infection in a 9-year-old 4-month-old girl with morbid obesity (BMI — 39 kg/m2, SDS BMI +4.98σ). Emphasis is placed on the lack of parallelism between the results of the procalcitonin test and the development of the septic process.Conclusion. Studies of domestic and foreign colleagues, as well as the clinical case we have cited, confirm that morbid obesity is a risk factor for the adverse course of COVID-19 in children.
{"title":"The effect of morbid obesity on the outcome of COVID-19 in a child","authors":"V. Sokolovskaya, A. A. Litvinova, A. V. Krikova, R. Kozlov","doi":"10.22627/2072-8107-2022-21-3-47-51","DOIUrl":"https://doi.org/10.22627/2072-8107-2022-21-3-47-51","url":null,"abstract":"Numerous works of domestic and foreign colleagues have proved that obesity is an independent risk factor for severe COVID-19 among patients of all age groups. Of particular interest is the study of the effect of overweight on the course of a new coronavirus infection in children and adolescents.Objective. Demonstration of a clinical case of fatal outcome of COVID-19 in a patient with morbid obesity; analysis and generalization of current data on the effect of obesity on the course of a new coronavirus infection in pediatric patients.The article presents a general understanding of the pathogenetic relationship between the two pathologies, as well as a case of a fatal outcome of a new coronavirus infection in a 9-year-old 4-month-old girl with morbid obesity (BMI — 39 kg/m2, SDS BMI +4.98σ). Emphasis is placed on the lack of parallelism between the results of the procalcitonin test and the development of the septic process.Conclusion. Studies of domestic and foreign colleagues, as well as the clinical case we have cited, confirm that morbid obesity is a risk factor for the adverse course of COVID-19 in children.","PeriodicalId":9855,"journal":{"name":"CHILDREN INFECTIONS","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90556801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-02DOI: 10.22627/2072-8107-2022-21-3-18-21
A. Bondarenko
Objective: to study the clinical and epidemiological features of the course of a new coronavirus infection in children of different ages undergoing outpatient treatment.The study participants were 812 children with COVID-19 aged from 1 month to 17 years, who were on outpatient treatment in the children's polyclinic of the city of Kirov from July to December 2021. The average age of patients with COVID-19 was 5.9 ± 1.1 years. Among the sick young children there were 28%, adolescents — 16%. In 76% of cases, contact with patients with a new coronavirus infection was detected, mainly in the family, as well as in educational institutions. In 70% of cases, an early request for medical help was registered — in the first three days of illness. In most cases (89%), a mild severity of the disease was established with the development of subfebrile fever and pharyngitis. Rhinitis phenomena were recorded in 20% of cases. 7% of children complained of a dry cough. Lung tissue lesion (RG1) was detected in 5% of patients, gastrointestinal tract — 5%. In adolescents, the phenomena of rhinitis, pharyngitis, dry cough were less common than in other age groups. Recombinant interferon alpha-2b and umifenovir were used for etiotropic therapy. All children recovered within 7—10 days from the onset of the disease.
{"title":"Features of the course of COVID-19 in children undergoing outpatient treatment","authors":"A. Bondarenko","doi":"10.22627/2072-8107-2022-21-3-18-21","DOIUrl":"https://doi.org/10.22627/2072-8107-2022-21-3-18-21","url":null,"abstract":"Objective: to study the clinical and epidemiological features of the course of a new coronavirus infection in children of different ages undergoing outpatient treatment.The study participants were 812 children with COVID-19 aged from 1 month to 17 years, who were on outpatient treatment in the children's polyclinic of the city of Kirov from July to December 2021. The average age of patients with COVID-19 was 5.9 ± 1.1 years. Among the sick young children there were 28%, adolescents — 16%. In 76% of cases, contact with patients with a new coronavirus infection was detected, mainly in the family, as well as in educational institutions. In 70% of cases, an early request for medical help was registered — in the first three days of illness. In most cases (89%), a mild severity of the disease was established with the development of subfebrile fever and pharyngitis. Rhinitis phenomena were recorded in 20% of cases. 7% of children complained of a dry cough. Lung tissue lesion (RG1) was detected in 5% of patients, gastrointestinal tract — 5%. In adolescents, the phenomena of rhinitis, pharyngitis, dry cough were less common than in other age groups. Recombinant interferon alpha-2b and umifenovir were used for etiotropic therapy. All children recovered within 7—10 days from the onset of the disease.","PeriodicalId":9855,"journal":{"name":"CHILDREN INFECTIONS","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84669089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-02DOI: 10.22627/2072-8107-2022-21-3-5-9
S. G. Gorbunov, L. Mazankova, A. N. Os’kin
It was found that the clinical picture of rotavirus infection in infants with an initially low number of immunocompetent cells expressing TLR-3 does not differ significantly from that of patients with an initially large number of cells expressing TLR-3. When analyzing the treatment, it turned out that antibacterial therapy due to the activation of bacterial microflora was used only in children with an initially low number of immunocompetent cells expressing TLR-3. In the same group of patients, the development of atopic dermatitis and food allergies was noted during catamnestic observation for 6—12 months after rotavirus infection.
{"title":"The role of TLR-3 in the course and outcomes of rotavirus infection in infants","authors":"S. G. Gorbunov, L. Mazankova, A. N. Os’kin","doi":"10.22627/2072-8107-2022-21-3-5-9","DOIUrl":"https://doi.org/10.22627/2072-8107-2022-21-3-5-9","url":null,"abstract":"It was found that the clinical picture of rotavirus infection in infants with an initially low number of immunocompetent cells expressing TLR-3 does not differ significantly from that of patients with an initially large number of cells expressing TLR-3. When analyzing the treatment, it turned out that antibacterial therapy due to the activation of bacterial microflora was used only in children with an initially low number of immunocompetent cells expressing TLR-3. In the same group of patients, the development of atopic dermatitis and food allergies was noted during catamnestic observation for 6—12 months after rotavirus infection.","PeriodicalId":9855,"journal":{"name":"CHILDREN INFECTIONS","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74732587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-02DOI: 10.22627/2072-8107-2022-21-3-68-72
O. G. Kimirilova, G. A. Kharchenko
Natural focal infections with transmissible transmission caused by viruses of West Nile Fever, Batai, Inco, Sindbis, Tyagin are registered in various territories of Russia, in the form of sporadic cases, characterized by polymorphism of clinical symptoms, from inapparent forms to severe, occurring with Central nervous system damage (meningitis, meningoencephalitis), which complicates the timely diagnosis and treatment of this pathology.Purpose: to describe our own clinical observations of five cases of arbovirus fevers.Results. Arbovirus fevers (West Nile Fever, Batai, Inko, Tyaginya) in the five clinical cases we have presented occurred in two clinical forms: catarrhal with hypertension syndrome, febrile fever and intense headache, vomiting in the absence of signs of inflammation in the CSF; and with damage to the central nervous system (meningitis). Catarrhal forms of arboviral fevers must be differentiated from ARVI, influenza, mononucleosis. Arbovirus fevers occurring with Central nervous system lesions (meningitis) had a significant similarity with enteroviral meningitis, both in terms of seasonality and clinical symptoms.Conclusion. In the territories of Russia endemic for mosquito fevers, in the summer period of the year, febrile patients with cerebral symptoms and / or meningeal symptoms should be examined for a group of arbovirus fevers.
{"title":"Arbovirus fevers in children and adults in the Astrakhan region: clinical cases","authors":"O. G. Kimirilova, G. A. Kharchenko","doi":"10.22627/2072-8107-2022-21-3-68-72","DOIUrl":"https://doi.org/10.22627/2072-8107-2022-21-3-68-72","url":null,"abstract":"Natural focal infections with transmissible transmission caused by viruses of West Nile Fever, Batai, Inco, Sindbis, Tyagin are registered in various territories of Russia, in the form of sporadic cases, characterized by polymorphism of clinical symptoms, from inapparent forms to severe, occurring with Central nervous system damage (meningitis, meningoencephalitis), which complicates the timely diagnosis and treatment of this pathology.Purpose: to describe our own clinical observations of five cases of arbovirus fevers.Results. Arbovirus fevers (West Nile Fever, Batai, Inko, Tyaginya) in the five clinical cases we have presented occurred in two clinical forms: catarrhal with hypertension syndrome, febrile fever and intense headache, vomiting in the absence of signs of inflammation in the CSF; and with damage to the central nervous system (meningitis). Catarrhal forms of arboviral fevers must be differentiated from ARVI, influenza, mononucleosis. Arbovirus fevers occurring with Central nervous system lesions (meningitis) had a significant similarity with enteroviral meningitis, both in terms of seasonality and clinical symptoms.Conclusion. In the territories of Russia endemic for mosquito fevers, in the summer period of the year, febrile patients with cerebral symptoms and / or meningeal symptoms should be examined for a group of arbovirus fevers.","PeriodicalId":9855,"journal":{"name":"CHILDREN INFECTIONS","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74307720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-02DOI: 10.22627/2072-8107-2022-21-3-28-32
L. Kravchenko, M. Levkovich, S. Berezhanskaya, A. Afonin, I. Krukier, O. Puzikova, I. Panova, D. Sozaeva, V. Popova, N. Drukker
Objective: based on the production of cytokines, to identify the immunological features of the chronic course of cytomegalovirus infection in children of the first year of life against the background of hypoxic-ischemic CNS damage.Research methods:108 newborns with cytomegalovirus infection occurring against the background of perinatal hypoxic-ischemic lesions of the central unequal system were examined. All observed patients immediately after the diagnosis of cytomegalovirus infection underwent an immunological examination, including the determination of the levels of interferon-alpha (IFN-α) and interferon-gamma (IFN-γ), the level of interleukins — 2 and 4 (IL -2 and IL-4) necrosis factor human alpha tumors (TNF-α in blood serum was determined by enzyme immunoassay using a set of reagents ProCon IF2 plus, ProCon Ifgamma, ProCon TNFα (Protein contour LLC, Russia, St. Petersburg). At 1 and 6 months of life .The observation groups consisted of 78 children (72.2%) with an acute course of the disease (Group 1) and 30 children (27.3%) with a chronic course (Group 2). The control group consisted of 15 newborns without herpes virus infection.Results. Of the totality of the studied cytokines, statistically significant for the chronic course of cytomegalovirus infection in children of the first year of life against the background of hypoxic-ischemic CNS damage were found: IL-2, IFN-γ. It was found that in children with a persistent low level of IFN-γ and an increased level of IL-4 in the blood serum at the age of 6 months, there was a chronic course of cytomegalovirus infection against the background of perinatal hypoxic-ischemic CNS damage.A decrease in IFN-γ production indicates a congenital or acquired deficiency of the interferon system and can be considered as an indication for long-term interferon replacement therapy.
{"title":"Clinical and diagnostic significance of determining the cytokine status in infants with chronic cytomegalovirus infection against the background of hypoxic-ischemic CNS damage","authors":"L. Kravchenko, M. Levkovich, S. Berezhanskaya, A. Afonin, I. Krukier, O. Puzikova, I. Panova, D. Sozaeva, V. Popova, N. Drukker","doi":"10.22627/2072-8107-2022-21-3-28-32","DOIUrl":"https://doi.org/10.22627/2072-8107-2022-21-3-28-32","url":null,"abstract":"Objective: based on the production of cytokines, to identify the immunological features of the chronic course of cytomegalovirus infection in children of the first year of life against the background of hypoxic-ischemic CNS damage.Research methods:108 newborns with cytomegalovirus infection occurring against the background of perinatal hypoxic-ischemic lesions of the central unequal system were examined. All observed patients immediately after the diagnosis of cytomegalovirus infection underwent an immunological examination, including the determination of the levels of interferon-alpha (IFN-α) and interferon-gamma (IFN-γ), the level of interleukins — 2 and 4 (IL -2 and IL-4) necrosis factor human alpha tumors (TNF-α in blood serum was determined by enzyme immunoassay using a set of reagents ProCon IF2 plus, ProCon Ifgamma, ProCon TNFα (Protein contour LLC, Russia, St. Petersburg). At 1 and 6 months of life .The observation groups consisted of 78 children (72.2%) with an acute course of the disease (Group 1) and 30 children (27.3%) with a chronic course (Group 2). The control group consisted of 15 newborns without herpes virus infection.Results. Of the totality of the studied cytokines, statistically significant for the chronic course of cytomegalovirus infection in children of the first year of life against the background of hypoxic-ischemic CNS damage were found: IL-2, IFN-γ. It was found that in children with a persistent low level of IFN-γ and an increased level of IL-4 in the blood serum at the age of 6 months, there was a chronic course of cytomegalovirus infection against the background of perinatal hypoxic-ischemic CNS damage.A decrease in IFN-γ production indicates a congenital or acquired deficiency of the interferon system and can be considered as an indication for long-term interferon replacement therapy.","PeriodicalId":9855,"journal":{"name":"CHILDREN INFECTIONS","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83992261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-02DOI: 10.22627/2072-8107-2022-21-3-10-17
V. Denisenko, E. M. Simovanyan
Objective – to characterize the clinic and the immune status state in children with HIV infection, taking into account the presence of congenital CMVI.Methods. A clinical and laboratory examination of 91 children with HIV infection with congenital CMVI (20; group I) and without it (71; group II) was carried out. Results. The anamnestic risk groups for congenital CMVI on the part of the mother included age over 30 years (55%), drug use (75%), chronic metroendometritis (85%), colpitis (55%), features of HIV status (secondary disease stage 4 — in 20%, CD4-lymphocyte count 0,5 х 109/l or less in 85%, HIV blood viral load 50 cop./ml or more in 80%), pregnancy pathology (threat of miscarriage — in 50%, developmental delay fetus — in 65%), lack of chemoprophylaxis for vertical transmission of HIV (55%). The clinical criteria for diagnosing of congenital CMVI in newborns included prematurity (40%), congenital malformations (45%), intrauterine growth retardation (65%), jaundice syndrome (50%), and perinatal CNS damage (80%). Children with congenital CMVI at the age of three months developed multiple organ pathology — lymphadenopathy (80%), hepatomegaly (65%), splenomegaly (40%), underweight (75%), pneumonia (60%), hepatitis (30%), pancreatitis (15%), enterocolitis (20%), nephritis (25%), carditis (20%), encephalitis (15%), chorioretinitis (20%), anemia (60%), thrombocytopenia (15%). A severe immunodeficiency state with a predominant violation of the T-cell link was revealed. A high titer of CMV was found in biological materials, IgG antibodies in the blood.Conclusion. The use of clinical and laboratory criteria makes it possible to timely diagnose congenital CMVI in children with HIV infection and prescribe complex therapy.
{"title":"Clinical and immunological characteristics of congenital cytomegalovirus infection in children with HIV infection","authors":"V. Denisenko, E. M. Simovanyan","doi":"10.22627/2072-8107-2022-21-3-10-17","DOIUrl":"https://doi.org/10.22627/2072-8107-2022-21-3-10-17","url":null,"abstract":"Objective – to characterize the clinic and the immune status state in children with HIV infection, taking into account the presence of congenital CMVI.Methods. A clinical and laboratory examination of 91 children with HIV infection with congenital CMVI (20; group I) and without it (71; group II) was carried out. Results. The anamnestic risk groups for congenital CMVI on the part of the mother included age over 30 years (55%), drug use (75%), chronic metroendometritis (85%), colpitis (55%), features of HIV status (secondary disease stage 4 — in 20%, CD4-lymphocyte count 0,5 х 109/l or less in 85%, HIV blood viral load 50 cop./ml or more in 80%), pregnancy pathology (threat of miscarriage — in 50%, developmental delay fetus — in 65%), lack of chemoprophylaxis for vertical transmission of HIV (55%). The clinical criteria for diagnosing of congenital CMVI in newborns included prematurity (40%), congenital malformations (45%), intrauterine growth retardation (65%), jaundice syndrome (50%), and perinatal CNS damage (80%). Children with congenital CMVI at the age of three months developed multiple organ pathology — lymphadenopathy (80%), hepatomegaly (65%), splenomegaly (40%), underweight (75%), pneumonia (60%), hepatitis (30%), pancreatitis (15%), enterocolitis (20%), nephritis (25%), carditis (20%), encephalitis (15%), chorioretinitis (20%), anemia (60%), thrombocytopenia (15%). A severe immunodeficiency state with a predominant violation of the T-cell link was revealed. A high titer of CMV was found in biological materials, IgG antibodies in the blood.Conclusion. The use of clinical and laboratory criteria makes it possible to timely diagnose congenital CMVI in children with HIV infection and prescribe complex therapy.","PeriodicalId":9855,"journal":{"name":"CHILDREN INFECTIONS","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87794141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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