Pub Date : 2019-06-30DOI: 10.3760/CMA.J.ISSN.1674-635X.2019.03.004
Jinchun Liu, Dayu Chen, X. Bian, Yizhong You, Xia Chen, Ping Cai, D. Lv, Miao Hu, J. Pang
Objective To investigate the use of parenteral nutrition preparations in Jiangsu Province, and to provide reference for the standardized management of parenteral nutrition preparations. Methods 720 cases using parenteral nutrition preparations from January 2017 to June 2017 in the department of general surgery of 12 hospitals in Jiangsu province were selected. The rate of nutritional risk screening, the indications of parenteral nutrition, the way of infusion, the rationality and economy of the prescriptions were retrospectively evaluated. The calorie, amino acid content, non-protein calorie/nitrogen ratio, glycolipid ratio and cation concentration of the patients received total parenteral nutrition were calculated. Results The total costs of parenteral nutrition preparations of 720 cases were 1.614 1 millions, and 346 cases did not have the indications for parenteral nutrition. The results of prescription comment showed that only 16 patients were screened for nutritional risk by Nutritional Risk Screening 2002 tool at admission. 544 cases were intravenous dripped with amino acid and fat emulsion from peripheral vein. In the 176 total parenteral nutrition prescriptions, there were 39 non-protein calorie/nitrogen ratio cases, 15 glycolipid ratio cases, 69 cation concentration cases, 61 calorie cases and 32 amino acid content cases failing to comply with the recommendation of the guidelines. Only 31 total parenteral nutrition prescriptions were completely reasonable. Conclusion The costs of parenteral nutrition preparations used in hospitals of Jiangsu are high but the rate of rationality is low. Nutrition support team should be established to regulate the use of parenteral nutrition preparations and save medical resources. Key words: Parenteral nutrition; Nutritional Risk Screening 2002; Nutritional risk screening; Nutrition support team
{"title":"Investigation on the utilization of parenteral nutrition preparations in 12 Hospitals of Jiangsu","authors":"Jinchun Liu, Dayu Chen, X. Bian, Yizhong You, Xia Chen, Ping Cai, D. Lv, Miao Hu, J. Pang","doi":"10.3760/CMA.J.ISSN.1674-635X.2019.03.004","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-635X.2019.03.004","url":null,"abstract":"Objective \u0000To investigate the use of parenteral nutrition preparations in Jiangsu Province, and to provide reference for the standardized management of parenteral nutrition preparations. \u0000 \u0000 \u0000Methods \u0000720 cases using parenteral nutrition preparations from January 2017 to June 2017 in the department of general surgery of 12 hospitals in Jiangsu province were selected. The rate of nutritional risk screening, the indications of parenteral nutrition, the way of infusion, the rationality and economy of the prescriptions were retrospectively evaluated. The calorie, amino acid content, non-protein calorie/nitrogen ratio, glycolipid ratio and cation concentration of the patients received total parenteral nutrition were calculated. \u0000 \u0000 \u0000Results \u0000The total costs of parenteral nutrition preparations of 720 cases were 1.614 1 millions, and 346 cases did not have the indications for parenteral nutrition. The results of prescription comment showed that only 16 patients were screened for nutritional risk by Nutritional Risk Screening 2002 tool at admission. 544 cases were intravenous dripped with amino acid and fat emulsion from peripheral vein. In the 176 total parenteral nutrition prescriptions, there were 39 non-protein calorie/nitrogen ratio cases, 15 glycolipid ratio cases, 69 cation concentration cases, 61 calorie cases and 32 amino acid content cases failing to comply with the recommendation of the guidelines. Only 31 total parenteral nutrition prescriptions were completely reasonable. \u0000 \u0000 \u0000Conclusion \u0000The costs of parenteral nutrition preparations used in hospitals of Jiangsu are high but the rate of rationality is low. Nutrition support team should be established to regulate the use of parenteral nutrition preparations and save medical resources. \u0000 \u0000 \u0000Key words: \u0000Parenteral nutrition; Nutritional Risk Screening 2002; Nutritional risk screening; Nutrition support team","PeriodicalId":9877,"journal":{"name":"Chinese Journal of Clinical Nutrition","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49266682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-06-30DOI: 10.3760/CMA.J.ISSN.1674-635X.2019.03.011
Y. Sheng, Lanzheng Bian, Li Wei
Objective To explore the nursing intervention effects of different volume syringe on flushing the jejunum nutrient tube for enteral nutrition pipeline obstruction among pediatric patients. Methods 62 pediatric patients with pipe plugging were selected and randomly divided into observation group and control group. Different volume syringes as 5 ml and 10 ml were used as punching tools respectively. The cases of recanalization, the rate of one time recanalization, the rate of unplanned extubation and the total time for nurse treatment of pipe plugging were compared between the two groups. Results There were no significant difference in the cases of recanalization, the rate of one time recanalization and unplanned extubation between the two groups (P>0.05). The total time for nurse treatment of pipe plugging in the control group was higher than that in the observation group[(8.2±1.2)h vs. (7.2±0.9)h, P<0.05]. Conclusion 5 ml volume syringe as a tube washing tool after pipeline obstruction, can not only save labors but also save time, which can improve the work efficiency of nurses. Key words: Syringe; Jejunum nutrient tube; Pipeline obstruction; Pediatric patients
{"title":"Effects of different volume syringe on recanalization of indwelling jejunal feeding tube in pediatric patients","authors":"Y. Sheng, Lanzheng Bian, Li Wei","doi":"10.3760/CMA.J.ISSN.1674-635X.2019.03.011","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-635X.2019.03.011","url":null,"abstract":"Objective \u0000To explore the nursing intervention effects of different volume syringe on flushing the jejunum nutrient tube for enteral nutrition pipeline obstruction among pediatric patients. \u0000 \u0000 \u0000Methods \u000062 pediatric patients with pipe plugging were selected and randomly divided into observation group and control group. Different volume syringes as 5 ml and 10 ml were used as punching tools respectively. The cases of recanalization, the rate of one time recanalization, the rate of unplanned extubation and the total time for nurse treatment of pipe plugging were compared between the two groups. \u0000 \u0000 \u0000Results \u0000There were no significant difference in the cases of recanalization, the rate of one time recanalization and unplanned extubation between the two groups (P>0.05). The total time for nurse treatment of pipe plugging in the control group was higher than that in the observation group[(8.2±1.2)h vs. (7.2±0.9)h, P<0.05]. \u0000 \u0000 \u0000Conclusion \u00005 ml volume syringe as a tube washing tool after pipeline obstruction, can not only save labors but also save time, which can improve the work efficiency of nurses. \u0000 \u0000 \u0000Key words: \u0000Syringe; Jejunum nutrient tube; Pipeline obstruction; Pediatric patients","PeriodicalId":9877,"journal":{"name":"Chinese Journal of Clinical Nutrition","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41590173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-06-30DOI: 10.3760/CMA.J.ISSN.1674-635X.2019.03.008
Tianzhu He, Qiang Hu, Lucy M. Zhang
Objective To compare the quality of life, nutritional status and immune function of gastric cancer patients with digestive tract reconstruction using Roux-en-Y anastomosis and uncut Roux-en-Y anastomosis after radical gastrectomy. Methods 86 patients with gastric cancer were selected from May 2015 to June 2017 with radical total gastrectomy. According to the different ways of the reconstruction of the digestive tract, the patients were divided into URY group (non-severed group, 41 patients) and RY group (traditional group, 45 patients). The quality of life of the two groups was compared at 1 month, 3 months and 6 months after operation. The nutritional status of albumin, prealbumin, transferrin, hemoglobin, retinol binding protein and weight, as well as CD4+ lymphocyte, CD8+ lymphocyte, CD4+ / CD8+ ratio, IgG, IgM, IgA and other immune related indexes were observed at pre-operation and 1 month, 3 months and 6 months after operation. Results As for quality of life, the score of diet limitation in group URY was significantly lower than that in group RY at 1 month after operation (P 0.05); As for anxiety, the score of group URY was higher than that in group RY (P 0.05). As for the nutritional indexes, prealbumin in the URY group was higher than that in the RY group at 6 months after operation (P 0.05). There was no statistical significance in immune indexes between the two groups (P>0.05). The postoperative hospitalization time of URY group was less than that of RY group (P 0.05). Conclusion Except for the length of hospitalization and postoperative complications in which uncut Roux-en-Y anastomosis was superior to Roux-en-Y anastomosis, there is no significant difference in quality of life and nutritional and immune indicators between the two alimentary tract reconstruction methods. Key words: Gastric cancer; Digestive tract reconstruction; Quality of life; Nutrition; Immune
{"title":"Effects of two different reconstruction methods of digestive tract after radical total gastrectomy on quality of life and immune nutrition status in patients with gastric cancer","authors":"Tianzhu He, Qiang Hu, Lucy M. Zhang","doi":"10.3760/CMA.J.ISSN.1674-635X.2019.03.008","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-635X.2019.03.008","url":null,"abstract":"Objective \u0000To compare the quality of life, nutritional status and immune function of gastric cancer patients with digestive tract reconstruction using Roux-en-Y anastomosis and uncut Roux-en-Y anastomosis after radical gastrectomy. \u0000 \u0000 \u0000Methods \u000086 patients with gastric cancer were selected from May 2015 to June 2017 with radical total gastrectomy. According to the different ways of the reconstruction of the digestive tract, the patients were divided into URY group (non-severed group, 41 patients) and RY group (traditional group, 45 patients). The quality of life of the two groups was compared at 1 month, 3 months and 6 months after operation. The nutritional status of albumin, prealbumin, transferrin, hemoglobin, retinol binding protein and weight, as well as CD4+ lymphocyte, CD8+ lymphocyte, CD4+ / CD8+ ratio, IgG, IgM, IgA and other immune related indexes were observed at pre-operation and 1 month, 3 months and 6 months after operation. \u0000 \u0000 \u0000Results \u0000As for quality of life, the score of diet limitation in group URY was significantly lower than that in group RY at 1 month after operation (P 0.05); As for anxiety, the score of group URY was higher than that in group RY (P 0.05). As for the nutritional indexes, prealbumin in the URY group was higher than that in the RY group at 6 months after operation (P 0.05). There was no statistical significance in immune indexes between the two groups (P>0.05). The postoperative hospitalization time of URY group was less than that of RY group (P 0.05). \u0000 \u0000 \u0000Conclusion \u0000Except for the length of hospitalization and postoperative complications in which uncut Roux-en-Y anastomosis was superior to Roux-en-Y anastomosis, there is no significant difference in quality of life and nutritional and immune indicators between the two alimentary tract reconstruction methods. \u0000 \u0000 \u0000Key words: \u0000Gastric cancer; Digestive tract reconstruction; Quality of life; Nutrition; Immune","PeriodicalId":9877,"journal":{"name":"Chinese Journal of Clinical Nutrition","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43297634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-06-30DOI: 10.3760/CMA.J.ISSN.1674-635X.2018.03.012
Yantao Duan
Sensing of nutrients and intestinal microecology are necessary for life. The nutrient sensing molecules are key factors to regulate a series of pathophysiological processes in nutrition metabolism. Microbial sensing molecules in the gut play critical roles in intestinal microecology and maintenance of the gut homeostasis. However, the specific mechanism remains to be further explored. This article reviews the intestinal nutrient sensing system and the molecular regulation mechanism of the intestinal microelogy. Key words: Nutrient sensing system; Intestinal microecology; Homeostasis; Review
{"title":"Sensing of nutrients and intestinal microecology","authors":"Yantao Duan","doi":"10.3760/CMA.J.ISSN.1674-635X.2018.03.012","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-635X.2018.03.012","url":null,"abstract":"Sensing of nutrients and intestinal microecology are necessary for life. The nutrient sensing molecules are key factors to regulate a series of pathophysiological processes in nutrition metabolism. Microbial sensing molecules in the gut play critical roles in intestinal microecology and maintenance of the gut homeostasis. However, the specific mechanism remains to be further explored. This article reviews the intestinal nutrient sensing system and the molecular regulation mechanism of the intestinal microelogy. \u0000 \u0000 \u0000Key words: \u0000Nutrient sensing system; Intestinal microecology; Homeostasis; Review","PeriodicalId":9877,"journal":{"name":"Chinese Journal of Clinical Nutrition","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47750711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-06-30DOI: 10.3760/CMA.J.ISSN.1674-635X.2019.03.002
Ying Xu, P. Liang, Y. Wen-kui, Zhanghua Zhu, L. Ning, Dan-jiang Dong, Jian-zhun Tang, Yong You, Yan Wang, Chen Ming, Yang Liu
Objective To investigate the effects of protein intake in the early phase and later phase on the outcomes of critically ill patients. Methods A total of 326 critically ill patients admitted in intensive care unit of our hospital from September 2016 to March 2018 were enrolled in this prospective observational study. According to the 28-day prognosis of patients, they were divided into death group and survival group. Early protein target (EPT) was defined as the daily protein intake≥0.8 g/(kg·d) on days 1-3, and late protein target (LPT) was defined as the daily protein intake≥0.8 g/(k·d) on days 4-7. Results Daily protein intakes on day 1 and day 3 and cumulative protein intakes on days 1-3 were significantly higher in non-survivors than in the survivors (P 0.05). Hospital mortality was the lowest in the LPT group, the highest in the EPT, and in the middle in the EPT+ LPT group and non-EPT+ non-LPT group (P<0.05). The survival curve analysis showed that the survival time of the EPT-only group was significantly lower than that of the LPT-only group (P<0.05). Multivariate analysis showed that age, sex, cumulative protein and caloric intakes on days 1-7 were the independent risk factors for mortality. Conclusion Early low protein intake is benefit for the outcomes of critically ill patients, and combined with adequate intake of protein in the later stage may further improve the outcomes. Key words: Critically ill patients; Protein intake; Caloric intake; Outcome
{"title":"Effect of early enough protein intake on outcomes of critically ill patients","authors":"Ying Xu, P. Liang, Y. Wen-kui, Zhanghua Zhu, L. Ning, Dan-jiang Dong, Jian-zhun Tang, Yong You, Yan Wang, Chen Ming, Yang Liu","doi":"10.3760/CMA.J.ISSN.1674-635X.2019.03.002","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-635X.2019.03.002","url":null,"abstract":"Objective \u0000To investigate the effects of protein intake in the early phase and later phase on the outcomes of critically ill patients. \u0000 \u0000 \u0000Methods \u0000A total of 326 critically ill patients admitted in intensive care unit of our hospital from September 2016 to March 2018 were enrolled in this prospective observational study. According to the 28-day prognosis of patients, they were divided into death group and survival group. Early protein target (EPT) was defined as the daily protein intake≥0.8 g/(kg·d) on days 1-3, and late protein target (LPT) was defined as the daily protein intake≥0.8 g/(k·d) on days 4-7. \u0000 \u0000 \u0000Results \u0000Daily protein intakes on day 1 and day 3 and cumulative protein intakes on days 1-3 were significantly higher in non-survivors than in the survivors (P 0.05). Hospital mortality was the lowest in the LPT group, the highest in the EPT, and in the middle in the EPT+ LPT group and non-EPT+ non-LPT group (P<0.05). The survival curve analysis showed that the survival time of the EPT-only group was significantly lower than that of the LPT-only group (P<0.05). Multivariate analysis showed that age, sex, cumulative protein and caloric intakes on days 1-7 were the independent risk factors for mortality. \u0000 \u0000 \u0000Conclusion \u0000Early low protein intake is benefit for the outcomes of critically ill patients, and combined with adequate intake of protein in the later stage may further improve the outcomes. \u0000 \u0000 \u0000Key words: \u0000Critically ill patients; Protein intake; Caloric intake; Outcome","PeriodicalId":9877,"journal":{"name":"Chinese Journal of Clinical Nutrition","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43778768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-06-30DOI: 10.3760/CMA.J.ISSN.1674-635X.2019.03.009
Fengmei Yu, Lei Shi, K. Li, Ningjie Ning, Maojun Chen
Objective To compare delivery accuracy and precision of nutrients as well as physicochemical property between self-made homogenate diet and commercial dairy based enteral nutrition product and investigate the clinical significances. Methods GB methods were used to examine and analyze the nutrients in self-made homogenate diet and commercial dairy based protein product. Results Self-made homogenate diet exhibited high viscosity (20, 000±2121.32) cps because of high water content. The actual values for macronutrients and energy were all lower than 10% of designed values. The actual values for lipid soluble vitamins A and E were only 49.32% and 56.47% of designed values, while the actual values for water soluble vitamins B1, B6 and C were all very low that were close to or lower than detection levels. All minerals, except for potassium were lower than the designed values, wherein iron was only 25.16% of designed value. For commercial enteral nutrition product, the actual contents of energy, macro- and micro-nutrients including vitamins and minerals were all higher than the designed values and the difference between the contents of minerals and its designed values were controlled within deviation range (5%~10%). Conclusion For vitamins and minerals in self-made homogenate diet, non-linear correlation was identified between the testing value and designed value. Commercial enteral nutrition product can provide more accurate nutrient level to reach the designed value, and has better flexibility on individual nutrient fortification. Key words: Nutrients; Accuracy; Homogenate diet; Enteral nutrition product
{"title":"Comparison of nutrients between self-made homogenate diet and industcialigod enteral nutrition product","authors":"Fengmei Yu, Lei Shi, K. Li, Ningjie Ning, Maojun Chen","doi":"10.3760/CMA.J.ISSN.1674-635X.2019.03.009","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-635X.2019.03.009","url":null,"abstract":"Objective \u0000To compare delivery accuracy and precision of nutrients as well as physicochemical property between self-made homogenate diet and commercial dairy based enteral nutrition product and investigate the clinical significances. \u0000 \u0000 \u0000Methods \u0000GB methods were used to examine and analyze the nutrients in self-made homogenate diet and commercial dairy based protein product. \u0000 \u0000 \u0000Results \u0000Self-made homogenate diet exhibited high viscosity (20, 000±2121.32) cps because of high water content. The actual values for macronutrients and energy were all lower than 10% of designed values. The actual values for lipid soluble vitamins A and E were only 49.32% and 56.47% of designed values, while the actual values for water soluble vitamins B1, B6 and C were all very low that were close to or lower than detection levels. All minerals, except for potassium were lower than the designed values, wherein iron was only 25.16% of designed value. For commercial enteral nutrition product, the actual contents of energy, macro- and micro-nutrients including vitamins and minerals were all higher than the designed values and the difference between the contents of minerals and its designed values were controlled within deviation range (5%~10%). \u0000 \u0000 \u0000Conclusion \u0000For vitamins and minerals in self-made homogenate diet, non-linear correlation was identified between the testing value and designed value. Commercial enteral nutrition product can provide more accurate nutrient level to reach the designed value, and has better flexibility on individual nutrient fortification. \u0000 \u0000 \u0000Key words: \u0000Nutrients; Accuracy; Homogenate diet; Enteral nutrition product","PeriodicalId":9877,"journal":{"name":"Chinese Journal of Clinical Nutrition","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42143284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-06-30DOI: 10.3760/CMA.J.ISSN.1674-635X.2019.03.006
Xuefeng Ni, Wen-bin Mu, L. Jiao, K. Yu
Objective To analyze the relationship between the abdominal fat and the progress of carotid atherosclerosis in the subject ageing 51-100 years. Methods 140 subjects receiving health examination in the department of health of Peking Union Medical College Hospital from 2015 to 2016 were included in the research. The abdominal fat area and distribution were calculated according to abdominal CT, and the progress of atherosclerosis in carotid artery was determined by ultrasound. Results In the population of 51-100 years old, there were no statistically significant difference in abdominal fat area and distribution among carotid artery plaque thickening group, arteriosclerosis non-progressing group and plaque reducing group; In the population of 51-80 years old, the total abdominal fat was significantly higher in carotid artery plaque thickening group than in arteriosclerosis non-progressing group and plaque reducing group (P=0.05, P=0.03), abdominal visceral fat area also increased, but no significant difference was found (P>0.05), and no significant differences in abdominal fat distribution was found (P>0.05. Conclusion The less total area of abdominal fat is, the slower the progress of atherosclerosis in carotid artery is in the population of 51-80 years old. Key words: Carotid atherosclerosis; Visceral fat; Subcutaneous fat; Obesity
{"title":"Correlation of abdominal fat area and distribution with carotid atherosclerosis progress in middle aged and elderly people","authors":"Xuefeng Ni, Wen-bin Mu, L. Jiao, K. Yu","doi":"10.3760/CMA.J.ISSN.1674-635X.2019.03.006","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-635X.2019.03.006","url":null,"abstract":"Objective \u0000To analyze the relationship between the abdominal fat and the progress of carotid atherosclerosis in the subject ageing 51-100 years. \u0000 \u0000 \u0000Methods \u0000140 subjects receiving health examination in the department of health of Peking Union Medical College Hospital from 2015 to 2016 were included in the research. The abdominal fat area and distribution were calculated according to abdominal CT, and the progress of atherosclerosis in carotid artery was determined by ultrasound. \u0000 \u0000 \u0000Results \u0000In the population of 51-100 years old, there were no statistically significant difference in abdominal fat area and distribution among carotid artery plaque thickening group, arteriosclerosis non-progressing group and plaque reducing group; In the population of 51-80 years old, the total abdominal fat was significantly higher in carotid artery plaque thickening group than in arteriosclerosis non-progressing group and plaque reducing group (P=0.05, P=0.03), abdominal visceral fat area also increased, but no significant difference was found (P>0.05), and no significant differences in abdominal fat distribution was found (P>0.05. \u0000 \u0000 \u0000Conclusion \u0000The less total area of abdominal fat is, the slower the progress of atherosclerosis in carotid artery is in the population of 51-80 years old. \u0000 \u0000 \u0000Key words: \u0000Carotid atherosclerosis; Visceral fat; Subcutaneous fat; Obesity","PeriodicalId":9877,"journal":{"name":"Chinese Journal of Clinical Nutrition","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49256909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-30DOI: 10.3760/CMA.J.ISSN.1674-635X.2019.02.002
Jiapei Li, Weigang Zhao, T. Yuan, Yong Fu, Ying-yue Dong, Juan Li
Objective To explore the long-term outcome of postpartum glucose metabolism among patients with gestational hyperglycemia and its risk factors. Methods Patients with gestational hyperglycemia, diagnosed by 100 g oral glucose tolerance test(OGTT) during 24th to 28th gestation week between 2010 and 2012 and giving the childbirth in Peking Union Medical College Hospital, were included. The glucose metabolism outcomes were evaluated by 75 g OGTT. The risk factors influencing the glucose metabolism outcome and the glucose metabolism parameter changes between the pregnancy term and now were also analyzed. Results Forty patients with gestational hyperglycemia were included. The follow-up time was postpartum 5-8 years and (6.83±0.74)years on average. Among them, 3 patients were diagnosed with type 2 diabetes and 9 patients were diagnosed with impaired glucose intolerance. The overall rate of abnormal glucose metabolism was 30 percent. The third-hour glucose of OGTT larger than 7.45 mmol/L and the area under the glucose curve(Glu AUC) during OGTT larger than 24.875 mmol×h/L were the risk factors for the abnormal glucose metabolism outcome, with the odds ratio of 5.769 (95% confidence interval 1.064-31.270, P=0.042) and 12.5(95% confidence interval 2.226-70.187, P=0.004). Using the 2-hour glucose larger than 8.25 mmol/L and 3-hour glucose larger than 7.45 mmol/L in the OGTT of midtrimester to judge the glucose state in the follow-up visit can achieve the diagnostic efficacy with the sensitivity of 75%, specificity of 82%, positive prediction value of 64% and negative prediction value of 88%. Comparing with now, the fasting glucose in the midtrimester was lower ([5.49±0.43] vs. [4.55±0.47] mmol/L, P<0.001), the fasting insulin in the midtrimester was higher (12.30[6.35, 16.55] vs. 8.31[6.79, 12.00] μIU/ml, P=0.048), HOMA-β in the midtrimester was higher (202.67[145.71, 335.71] vs. 85.41[78.63, 112.13], P<0.001). Conclusion The third-hour glucose larger than 7.45 mmol/L and the glucose area under the curve larger than 24.88 mmol×h/L in the OGTT of midtrimester are the risk factors for the abnormal glucose state in the postpartum long-term follow-up. The combination of the second-hour and the third-hour glucoses in the 100 g OGTT of midtrimester can help to predict the postpartum long-term glucose state. Key words: gestational hyperglycemia; postpartum long-term glucose metabolism
{"title":"Long-term outcome of postpartum glucose metabolism among patients with gestational hyperglycemia and its risk factors","authors":"Jiapei Li, Weigang Zhao, T. Yuan, Yong Fu, Ying-yue Dong, Juan Li","doi":"10.3760/CMA.J.ISSN.1674-635X.2019.02.002","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-635X.2019.02.002","url":null,"abstract":"Objective \u0000To explore the long-term outcome of postpartum glucose metabolism among patients with gestational hyperglycemia and its risk factors. \u0000 \u0000 \u0000Methods \u0000Patients with gestational hyperglycemia, diagnosed by 100 g oral glucose tolerance test(OGTT) during 24th to 28th gestation week between 2010 and 2012 and giving the childbirth in Peking Union Medical College Hospital, were included. The glucose metabolism outcomes were evaluated by 75 g OGTT. The risk factors influencing the glucose metabolism outcome and the glucose metabolism parameter changes between the pregnancy term and now were also analyzed. \u0000 \u0000 \u0000Results \u0000Forty patients with gestational hyperglycemia were included. The follow-up time was postpartum 5-8 years and (6.83±0.74)years on average. Among them, 3 patients were diagnosed with type 2 diabetes and 9 patients were diagnosed with impaired glucose intolerance. The overall rate of abnormal glucose metabolism was 30 percent. The third-hour glucose of OGTT larger than 7.45 mmol/L and the area under the glucose curve(Glu AUC) during OGTT larger than 24.875 mmol×h/L were the risk factors for the abnormal glucose metabolism outcome, with the odds ratio of 5.769 (95% confidence interval 1.064-31.270, P=0.042) and 12.5(95% confidence interval 2.226-70.187, P=0.004). Using the 2-hour glucose larger than 8.25 mmol/L and 3-hour glucose larger than 7.45 mmol/L in the OGTT of midtrimester to judge the glucose state in the follow-up visit can achieve the diagnostic efficacy with the sensitivity of 75%, specificity of 82%, positive prediction value of 64% and negative prediction value of 88%. Comparing with now, the fasting glucose in the midtrimester was lower ([5.49±0.43] vs. [4.55±0.47] mmol/L, P<0.001), the fasting insulin in the midtrimester was higher (12.30[6.35, 16.55] vs. 8.31[6.79, 12.00] μIU/ml, P=0.048), HOMA-β in the midtrimester was higher (202.67[145.71, 335.71] vs. 85.41[78.63, 112.13], P<0.001). \u0000 \u0000 \u0000Conclusion \u0000The third-hour glucose larger than 7.45 mmol/L and the glucose area under the curve larger than 24.88 mmol×h/L in the OGTT of midtrimester are the risk factors for the abnormal glucose state in the postpartum long-term follow-up. The combination of the second-hour and the third-hour glucoses in the 100 g OGTT of midtrimester can help to predict the postpartum long-term glucose state. \u0000 \u0000 \u0000Key words: \u0000gestational hyperglycemia; postpartum long-term glucose metabolism","PeriodicalId":9877,"journal":{"name":"Chinese Journal of Clinical Nutrition","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45160632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-30DOI: 10.3760/CMA.J.ISSN.1674-635X.2019.02.005
Deliang Lv, W. Tan, Jian Xu, Hui Yang, Jun-luan Mo, Yu-mei Zhu, Xiongshun Liang, X. Che, Qingfang Wu
Objective To explore the effect of first-line anti-tuberculosis treatment on vitamin D level in patients with pulmonary tuberculosis, and to master the changes of vitamin D level in the course of treatment, so as to provide a scientific basis for tuberculosis and nutrition health education in Shenzhen. Methods A total of 100 patients diagnosed as smear-positive pulmonary tuberculosis and receiving initial treatment in 2016 were enrolled and all the patients were treated with the standardized short-course chemotherapy regimens. The blood samples were extracted before treatment and at the ends of intensive and continuation phase. The 25-hydroxyvitamin D[25-(OH)D] concentrations were determined by chemiluminescence (CLIA)at each time point. The change of 25-(OH)D concentrations during anti-tuberculosis treatment was analyzed and the differences of vitamin D levels between different time points were identified. Results 79(79.0%), 94(94.0%) and 96(96.0%)patients were found vitamin D deficiency before treatment and at the end of the intensive and continuation phases respectively, which showed an upward trend(χ2=15.543, P<0.001)and the 25-(OH)D concentrations were (15.74±6.54)ng/ml, (12.56±5.15)ng/ml, (11.51±4.28)ng/ml, respectively. During the whole course of treatment, the 25-(OH)D concentration decreased by 26.9% or (4.23±6.75)ng/ml(t=6.257, P<0.001), wherein it decreased (3.18±5.24)ng/ml in intensive phase (t=6.069, P<0.001) and (1.05±4.86)ng/ml in continuation phase (t=2.154, P=0.034). The former had a greater decreased value (t=2.836, P=0.006). There were 77 (77.0%) and 55 (55.0%) patients with 25-(OH)D concentration reduction in intensive and continuation phases respectively(χ2=9.680, P=0.003), of which 41 patients (41.0%) continued to decline. Conclusion Once anti-tuberculosis treatment is conducted, the vitamin D level will decrease rapidly in the intensive phase and continue decreasing throughout the course of treatment, which leads to a general lack of vitamin D in patients with primary pulmonary tuberculosis. First-line anti-tuberculosis drugs may be the main cause for vitamin D level reduction. Therefore, it is necessary for clinicians to strengthen vitamin D health education for each patient throughout the treatment period, especially for those at high risk of vitamin D deficiency who should be recommended adjuvant vitamin D supplementation therapy. Key words: Pulmonary tuberculosis; Vitamin D deficiency; 25-hydroxyvitamin D; Anti-tuberculosis drug
{"title":"Effect of first-line antituberculous treatment on vitamin D level in patients with pulmonary tuberculosis","authors":"Deliang Lv, W. Tan, Jian Xu, Hui Yang, Jun-luan Mo, Yu-mei Zhu, Xiongshun Liang, X. Che, Qingfang Wu","doi":"10.3760/CMA.J.ISSN.1674-635X.2019.02.005","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-635X.2019.02.005","url":null,"abstract":"Objective \u0000To explore the effect of first-line anti-tuberculosis treatment on vitamin D level in patients with pulmonary tuberculosis, and to master the changes of vitamin D level in the course of treatment, so as to provide a scientific basis for tuberculosis and nutrition health education in Shenzhen. \u0000 \u0000 \u0000Methods \u0000A total of 100 patients diagnosed as smear-positive pulmonary tuberculosis and receiving initial treatment in 2016 were enrolled and all the patients were treated with the standardized short-course chemotherapy regimens. The blood samples were extracted before treatment and at the ends of intensive and continuation phase. The 25-hydroxyvitamin D[25-(OH)D] concentrations were determined by chemiluminescence (CLIA)at each time point. The change of 25-(OH)D concentrations during anti-tuberculosis treatment was analyzed and the differences of vitamin D levels between different time points were identified. \u0000 \u0000 \u0000Results \u000079(79.0%), 94(94.0%) and 96(96.0%)patients were found vitamin D deficiency before treatment and at the end of the intensive and continuation phases respectively, which showed an upward trend(χ2=15.543, P<0.001)and the 25-(OH)D concentrations were (15.74±6.54)ng/ml, (12.56±5.15)ng/ml, (11.51±4.28)ng/ml, respectively. During the whole course of treatment, the 25-(OH)D concentration decreased by 26.9% or (4.23±6.75)ng/ml(t=6.257, P<0.001), wherein it decreased (3.18±5.24)ng/ml in intensive phase (t=6.069, P<0.001) and (1.05±4.86)ng/ml in continuation phase (t=2.154, P=0.034). The former had a greater decreased value (t=2.836, P=0.006). There were 77 (77.0%) and 55 (55.0%) patients with 25-(OH)D concentration reduction in intensive and continuation phases respectively(χ2=9.680, P=0.003), of which 41 patients (41.0%) continued to decline. \u0000 \u0000 \u0000Conclusion \u0000Once anti-tuberculosis treatment is conducted, the vitamin D level will decrease rapidly in the intensive phase and continue decreasing throughout the course of treatment, which leads to a general lack of vitamin D in patients with primary pulmonary tuberculosis. First-line anti-tuberculosis drugs may be the main cause for vitamin D level reduction. Therefore, it is necessary for clinicians to strengthen vitamin D health education for each patient throughout the treatment period, especially for those at high risk of vitamin D deficiency who should be recommended adjuvant vitamin D supplementation therapy. \u0000 \u0000 \u0000Key words: \u0000Pulmonary tuberculosis; Vitamin D deficiency; 25-hydroxyvitamin D; Anti-tuberculosis drug","PeriodicalId":9877,"journal":{"name":"Chinese Journal of Clinical Nutrition","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42724276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective To evaluate the application way and value of autologous succus entericus reinfusion in neonatal enterostomy. Methods Clinical data from 109 neonatal patients receiving enterostomy in Children's Hospital of Nanjing Medical University from January 2010 to December 2017 were retrospectively analyzed. The neonatal patients were divided into two groups according to whether succus entericus reinfusion conducted as succus entericus reinfusion group (63 neonatal patients) and control group (46 neonatal patients). The 90-day weight gain of the neonatal patients, age of the second stage enterostomy closure, cessation of intravenous infusion time after operation and the rate of re-admission before the second stage enterostomy closure were collected. Results The distance between enterostomy mouth and the Treitz ligament was 80-120 cm in all the children patients, and there was no significant difference between the two groups (P=0.42). The succus entericus reinfusion group was superior to the control group in the weight gain of 90 days after birth (single lumen group vs. single lumen control group: [1.97±0.55] vs. [1.50±0.57]kg, P=0.017; double lumens group vs. double lumens control group: [1.82±0.49]vs. [1.48±0.65] kg, P=0.013), age of the second stage enterostomy closure (single lumen group vs. single lumen control group: [115.76±15.85] vs. [117.40±11.06] d, P=0.025; double lumens group vs. double lumens control group: [115.48±14.33] vs. [126.03±8.85] d, P=0.001), cessation of intravenous infusion time after operation (single lumen group vs. single lumen control group: [ 14.24±3.30] vs. [16.40±2.74] d, P=0.046; double lumens group vs. double lumens control group: [15.07±3.65] vs. [18.71±3.63] d, P<0.01), and the rate of re-admission before the second stage enterostomy closure (single lumen group vs. single lumen control group: 9.5%[2/21]vs. 20%[3/15], P=0.337; double lumens group vs. double lumens control group: 7.1%[3/42]vs. 25.8%[8/31], P=0.028). Conclusion Autologous succus entericus reinfusion can improve the absorption of nutrients after the operation of small intestinal stoma, improve the function of the distal enteral tube, and create conditions for the early recovery of intestinal continuity. Key words: Neonate; Small intestine stoma; Succus entericus reinfusion
目的探讨自体肠浆液回输在新生儿肠造口术中的应用方法及价值。方法回顾性分析2010年1月至2017年12月南京医科大学儿童医院109例接受肠造口术的新生儿的临床资料。根据是否进行肠浆液回输将新生儿患者分为肠浆液回输组(63例新生儿)和对照组(46例新生儿)。收集新生儿患者90天体重增加、二期肠造口术年龄、术后停止静脉输注时间、二期肠造口术前再入院率。结果患儿肠造口距Treitz韧带的距离均为80 ~ 120 cm，两组间差异无统计学意义(P=0.42)。肠浆液回输组出生后90 d增重优于对照组(单腔组vs单腔对照组:[1.97±0.55]vs[1.50±0.57]kg, P=0.017;双流明组与双流明对照组:[1.82±0.49]vs。[1.48±0.65]kg, P=0.013)，第二阶段肠造口闭合年龄(单腔组与单腔对照组:[115.76±15.85]∶[117.40±11.06]d, P=0.025;双腔组vs双腔对照组:[115.48±14.33]vs[126.03±8.85]d, P=0.001)，术后停止静脉输注时间(单腔组vs单腔对照组:[14.24±3.30]vs[16.40±2.74]d, P=0.046;双腔组与双腔对照组:[15.07±3.65]d vs[18.71±3.63]d, P<0.01)，二期肠造口前再入院率(单腔组与单腔对照组:9.5%[2/21]vs。20% (3/15), P = 0.337;双流明组vs双流明对照组:7.1%[3/42]vs。25.8% (8/31), P = 0.028)。结论自体肠浆液回输可改善小肠造口术后营养物质的吸收，改善远端肠管功能，为小肠连续性的早期恢复创造条件。关键词:新生儿;小肠造口;肠液回输
{"title":"Application of autologous succus entericus reinfusion after enterostomy in neonate","authors":"Yajuan Xu, Ping Yan, Yanbo Wang, Wen-Chun Sun, Weibing Tang","doi":"10.3760/CMA.J.ISSN.1674-635X.2019.02.011","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-635X.2019.02.011","url":null,"abstract":"Objective \u0000To evaluate the application way and value of autologous succus entericus reinfusion in neonatal enterostomy. \u0000 \u0000 \u0000Methods \u0000Clinical data from 109 neonatal patients receiving enterostomy in Children's Hospital of Nanjing Medical University from January 2010 to December 2017 were retrospectively analyzed. The neonatal patients were divided into two groups according to whether succus entericus reinfusion conducted as succus entericus reinfusion group (63 neonatal patients) and control group (46 neonatal patients). The 90-day weight gain of the neonatal patients, age of the second stage enterostomy closure, cessation of intravenous infusion time after operation and the rate of re-admission before the second stage enterostomy closure were collected. \u0000 \u0000 \u0000Results \u0000The distance between enterostomy mouth and the Treitz ligament was 80-120 cm in all the children patients, and there was no significant difference between the two groups (P=0.42). The succus entericus reinfusion group was superior to the control group in the weight gain of 90 days after birth (single lumen group vs. single lumen control group: [1.97±0.55] vs. [1.50±0.57]kg, P=0.017; double lumens group vs. double lumens control group: [1.82±0.49]vs. [1.48±0.65] kg, P=0.013), age of the second stage enterostomy closure (single lumen group vs. single lumen control group: [115.76±15.85] vs. [117.40±11.06] d, P=0.025; double lumens group vs. double lumens control group: [115.48±14.33] vs. [126.03±8.85] d, P=0.001), cessation of intravenous infusion time after operation (single lumen group vs. single lumen control group: [ 14.24±3.30] vs. [16.40±2.74] d, P=0.046; double lumens group vs. double lumens control group: [15.07±3.65] vs. [18.71±3.63] d, P<0.01), and the rate of re-admission before the second stage enterostomy closure (single lumen group vs. single lumen control group: 9.5%[2/21]vs. 20%[3/15], P=0.337; double lumens group vs. double lumens control group: 7.1%[3/42]vs. 25.8%[8/31], P=0.028). \u0000 \u0000 \u0000Conclusion \u0000Autologous succus entericus reinfusion can improve the absorption of nutrients after the operation of small intestinal stoma, improve the function of the distal enteral tube, and create conditions for the early recovery of intestinal continuity. \u0000 \u0000 \u0000Key words: \u0000Neonate; Small intestine stoma; Succus entericus reinfusion","PeriodicalId":9877,"journal":{"name":"Chinese Journal of Clinical Nutrition","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48164798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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