Pub Date : 2019-04-30DOI: 10.3760/CMA.J.ISSN.1674-635X.2019.02.003
Lei Shi, J. Gong, Yuan Liu, D. Mu, Xin Liao, Xiaoqing Zeng, Jiajie Yu
Objective To analyze the current status of studies related to home enteral nutrition (HEN) in China, and provide scientific basis for the research and management of HEN in China. Methods We searched CNKI and WanFang Data since it built to January 1st, 2018. The included studies were screened and categorized by publication information, study type, subjects of the study, topic, interventions and outcomes. Descriptive analysis was conducted after extraction of information. Results A total of 153 studies were included, of which 37 were observational studies, 102 were experimental studies, 12 were case report, and 2 were exploring articles. Since 2012, the number of studies has been increasing. Most of the subjects were elderly people who were diagnosed with diseases of digestive system, head and neck tumors and diseases of nervous system. These studies were featured as small sample size and short intervention time, follow-ups by telephone and home visit, less than 1/4 providing professional nutrition support team, and outcomes mainly as complication, nutritional biochemical indices, anthropometric indices and prognosis. Conclusion HEN in China is still in its infancy. The number of relative studies is still small and quality of literatures is very low, but it has been increasing. At present, there are some problems in the implementation of HEN in China, such as lack of standardized management model and professional team, short-term intervention, and single follow-up mode. The elderly and patients with digestive disease, head and neck tumors and nervous disease are the key subjects; more professional nutrition support team and scientific management model should be established in the future. Key words: Home enteral nutrition; Bibliometric analysis
{"title":"Bibliometric analysis of home enteral nutrition in China","authors":"Lei Shi, J. Gong, Yuan Liu, D. Mu, Xin Liao, Xiaoqing Zeng, Jiajie Yu","doi":"10.3760/CMA.J.ISSN.1674-635X.2019.02.003","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-635X.2019.02.003","url":null,"abstract":"Objective \u0000To analyze the current status of studies related to home enteral nutrition (HEN) in China, and provide scientific basis for the research and management of HEN in China. \u0000 \u0000 \u0000Methods \u0000We searched CNKI and WanFang Data since it built to January 1st, 2018. The included studies were screened and categorized by publication information, study type, subjects of the study, topic, interventions and outcomes. Descriptive analysis was conducted after extraction of information. \u0000 \u0000 \u0000Results \u0000A total of 153 studies were included, of which 37 were observational studies, 102 were experimental studies, 12 were case report, and 2 were exploring articles. Since 2012, the number of studies has been increasing. Most of the subjects were elderly people who were diagnosed with diseases of digestive system, head and neck tumors and diseases of nervous system. These studies were featured as small sample size and short intervention time, follow-ups by telephone and home visit, less than 1/4 providing professional nutrition support team, and outcomes mainly as complication, nutritional biochemical indices, anthropometric indices and prognosis. \u0000 \u0000 \u0000Conclusion \u0000HEN in China is still in its infancy. The number of relative studies is still small and quality of literatures is very low, but it has been increasing. At present, there are some problems in the implementation of HEN in China, such as lack of standardized management model and professional team, short-term intervention, and single follow-up mode. The elderly and patients with digestive disease, head and neck tumors and nervous disease are the key subjects; more professional nutrition support team and scientific management model should be established in the future. \u0000 \u0000 \u0000Key words: \u0000Home enteral nutrition; Bibliometric analysis","PeriodicalId":9877,"journal":{"name":"Chinese Journal of Clinical Nutrition","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43491042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective To investigate the vitamin B12 status of vegetarians in Shanghai. Methods A total of 282 adult vegetarians and 282 omnivores matching by gender and age were recruited in Shanghai. Their dietary intakes were collected. The serum concentrations of vitamin B12, folate and homocysteine were tested. The red blood cell, hematocrit value, mean corpuscular volume and mean erythrocyte width were also examined. Results The daily average intake of dietary vitamin B12 was(0.46±1.01) μg/d in vegetarians and only (0.1±0.46) μg/d in vegans, which was lower than that of omnivores [(3.91±6.92)μg/d, F=50.57, P<0.01] . 137 omnivores and 274 vegetarians had less dietary vitamin B12 level than recommended nutrient intake (RNI) and the difference was statistically significant (χ2=114.77, P<0.01). 54.26% of vegetarians, 68.92% vegans, 49.04% ovo-lacto vegetarians and 15.60% omnivores had hyperhomocysteinemia and the differences between vegetarians and omnivores were statistically significant (all P<0.01). After adjusting the confounding factors the hematocrit value was higher in vegetarians, vegans and ovo-lacto vegetarians than in omnivores(27.42%±18.32%, 28.73%±18.19%, 26.95%±18.38% vs. 8.96%±16.59%, P<0.01). Vegans had lower red blood cell counts and higher hematocrit value and mean corpuscular volume than omnivores. Conclusion Vitamin B12 deficiency combined with an elevated level of homocysteine and red blood cell volume growth are common but serious issue in vegetarians, especially in vegans. Key words: Vegetarian; Vitamin B12; Red blood cell; Homocysteine; Folate
{"title":"Vitamin B12 status of vegetarians in Shanghai","authors":"Xueying Cui, Bian Wang, Youmei Wu, Luyao Xie, Q. Tang","doi":"10.3760/CMA.J.ISSN.1674-635X.2019.02.008","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-635X.2019.02.008","url":null,"abstract":"Objective \u0000To investigate the vitamin B12 status of vegetarians in Shanghai. \u0000 \u0000 \u0000Methods \u0000A total of 282 adult vegetarians and 282 omnivores matching by gender and age were recruited in Shanghai. Their dietary intakes were collected. The serum concentrations of vitamin B12, folate and homocysteine were tested. The red blood cell, hematocrit value, mean corpuscular volume and mean erythrocyte width were also examined. \u0000 \u0000 \u0000Results \u0000The daily average intake of dietary vitamin B12 was(0.46±1.01) μg/d in vegetarians and only (0.1±0.46) μg/d in vegans, which was lower than that of omnivores [(3.91±6.92)μg/d, F=50.57, P<0.01] . 137 omnivores and 274 vegetarians had less dietary vitamin B12 level than recommended nutrient intake (RNI) and the difference was statistically significant (χ2=114.77, P<0.01). 54.26% of vegetarians, 68.92% vegans, 49.04% ovo-lacto vegetarians and 15.60% omnivores had hyperhomocysteinemia and the differences between vegetarians and omnivores were statistically significant (all P<0.01). After adjusting the confounding factors the hematocrit value was higher in vegetarians, vegans and ovo-lacto vegetarians than in omnivores(27.42%±18.32%, 28.73%±18.19%, 26.95%±18.38% vs. 8.96%±16.59%, P<0.01). Vegans had lower red blood cell counts and higher hematocrit value and mean corpuscular volume than omnivores. \u0000 \u0000 \u0000Conclusion \u0000Vitamin B12 deficiency combined with an elevated level of homocysteine and red blood cell volume growth are common but serious issue in vegetarians, especially in vegans. \u0000 \u0000 \u0000Key words: \u0000Vegetarian; Vitamin B12; Red blood cell; Homocysteine; Folate","PeriodicalId":9877,"journal":{"name":"Chinese Journal of Clinical Nutrition","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49133679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-30DOI: 10.3760/CMA.J.ISSN.1674-635X.2019.02.009
Lei Yu, F. Fang
Objective To investigate the effect of nutrition intake method with adaptive viscosity on nutritional status of laryngeal cancer patients with dysphagia after surgery and radiotherapy (RT). Methods 77 laryngeal carcinoma patients with dysphagia after surgery and radiotherapy were divided randomly into two groups by a random number table as study group (SG, n=39) and control group (CG, n=38). The CG received routine diet instruction and swallowing training, while the SG received oral nutritional supplementation with adaptive viscosity in additon. The body weight, body mass index (BMI), hemoglobin, albumin, prealbumin and scores of nutritional status at the end and 3 months after RT were compared between the two groups. Results There were 34 patients (87.2%) and 32 patients (84.2%) with nutritional status scores more than or equal to 2 at the end of RT in the two groups. At 3 months after RT, the body weight, BMI, hemoglobin, albumin, prealbumin, daily intake and nutritional status scores in the study group were significantly higher than those at the end of RT and those in the control group [(61.28±11.16) vs. (51.82±7.36), (56.44±10.69)kg; (20.57±6.13) vs. (18.81±4.43), (19.47±5.36)kg/m2; (134.87±17.86) vs. (114.68±15.25), (123.58±19.34)g/L; (40.74±7.54) vs. (36.77±5.27), (37.94±8.47)g/L; (312.83±35.83) vs. (271.56±32.82), (290.73±41.38)g/L; (2 047±126) vs. (1 512±143), (1 589±138)kcal; (2.36±0.93) vs. (3.70±1.80), (3.14±1.26); P all<0.05]. The level of the body weight and hemoglobin in the control group at 3 months after RT were significantly higher than those at end of RT [(56.44±10.69) vs. (51.56±8.34)kg, P=0.025; (123.58±19.34) vs. (113.36±16.56)g/L, P=0.023]. During 3 months, the rate of pulmonary infection was 1 (2.5%) in the study group and 6 (15.8%) in the control group and the difference was statistically significant (χ2=4.073, P=0.044). Conclusion Nutrition intake method with adaptive viscosity can effectively improve the nutritional status of laryngeal cancer patients with dysphagia after surgery and radiotherapy and reduce the infection rate of lung. Key words: Laryngeal neoplasm; Dysphagia; Nutrition intake method; Viscosity; Nutritional status
{"title":"Effect of nutrition intake method with adaptive viscosity on nutritional status of laryngeal cancer patients with dysphagia after surgery and radiotherapy","authors":"Lei Yu, F. Fang","doi":"10.3760/CMA.J.ISSN.1674-635X.2019.02.009","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-635X.2019.02.009","url":null,"abstract":"Objective \u0000To investigate the effect of nutrition intake method with adaptive viscosity on nutritional status of laryngeal cancer patients with dysphagia after surgery and radiotherapy (RT). \u0000 \u0000 \u0000Methods \u000077 laryngeal carcinoma patients with dysphagia after surgery and radiotherapy were divided randomly into two groups by a random number table as study group (SG, n=39) and control group (CG, n=38). The CG received routine diet instruction and swallowing training, while the SG received oral nutritional supplementation with adaptive viscosity in additon. The body weight, body mass index (BMI), hemoglobin, albumin, prealbumin and scores of nutritional status at the end and 3 months after RT were compared between the two groups. \u0000 \u0000 \u0000Results \u0000There were 34 patients (87.2%) and 32 patients (84.2%) with nutritional status scores more than or equal to 2 at the end of RT in the two groups. At 3 months after RT, the body weight, BMI, hemoglobin, albumin, prealbumin, daily intake and nutritional status scores in the study group were significantly higher than those at the end of RT and those in the control group [(61.28±11.16) vs. (51.82±7.36), (56.44±10.69)kg; (20.57±6.13) vs. (18.81±4.43), (19.47±5.36)kg/m2; (134.87±17.86) vs. (114.68±15.25), (123.58±19.34)g/L; (40.74±7.54) vs. (36.77±5.27), (37.94±8.47)g/L; (312.83±35.83) vs. (271.56±32.82), (290.73±41.38)g/L; (2 047±126) vs. (1 512±143), (1 589±138)kcal; (2.36±0.93) vs. (3.70±1.80), (3.14±1.26); P all<0.05]. The level of the body weight and hemoglobin in the control group at 3 months after RT were significantly higher than those at end of RT [(56.44±10.69) vs. (51.56±8.34)kg, P=0.025; (123.58±19.34) vs. (113.36±16.56)g/L, P=0.023]. During 3 months, the rate of pulmonary infection was 1 (2.5%) in the study group and 6 (15.8%) in the control group and the difference was statistically significant (χ2=4.073, P=0.044). \u0000 \u0000 \u0000Conclusion \u0000Nutrition intake method with adaptive viscosity can effectively improve the nutritional status of laryngeal cancer patients with dysphagia after surgery and radiotherapy and reduce the infection rate of lung. \u0000 \u0000 \u0000Key words: \u0000Laryngeal neoplasm; Dysphagia; Nutrition intake method; Viscosity; Nutritional status","PeriodicalId":9877,"journal":{"name":"Chinese Journal of Clinical Nutrition","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44124140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-30DOI: 10.3760/CMA.J.ISSN.1674-635X.2019.02.006
Xiu-ling Yang, Jie Yan, Changlu Pan, Wenli Zhao
Objective To evaluate the nutrional status and malnutrition risks of hospitalized children with acute lymphoblastic leukemia (ALL), provide nutrition support for subsequent treatment, lower nutritional risks and improve therapeutic effects; to complete the statistical analysis of height and weight across age through data normalization. Methods A total of 592 children diagnosed ALL from August 2014 to September 2016 at Beijing Children's Hospital were enrolled, and the directly measured height and weight which reflected the nutritional status of children were collected and normalized. Nutritional risk screening was completed by STAMP screening tool and the nutritional status was evaluated by three Z scores HAZ<-2, WAZ<-2 and WHZ<-2. The effects of nutrition intervention were investigated by weight, hemoglobin and albumin changes between before and after L-asp treatment. Results The Z score test showed that there was no significant difference between the nutritional status of pretreatment ALL patients(0.34% growth retardation, 2.36% lower body weight, 0.17% emaciation) and normal healthy children (3% malnutrition); after comparing the STAMP nutritional risk assessment and t test results for children with ALL, it was found that the proportion of children with high malnutrition risk ( score≥4 ) was 9.71%, which had a strong correlation with body mass index; the children with body mass index less than 0.80(50% children having malnutrition) or greater than 1.30(20% children having malnutrition) had a higher risk of malnutrition, and the body mass indexof the high-risk group(0.852 kg/m2) were significantly lower than that of the low risk group(1.051 kg/m2, score≤3 ); there were significant differences in height and weight between children with STAMP≤3 and STAMP≥4 (all P<0.05) Nutritional interventions made no significant weight change during treatment; For children with STAMP≤3 and STAMP≥4 in L-asp treatment, the hemoglobin value changed from (87.46±19.27)g/L to (95.12±13.51)g/L and (101.55±21.97)g/L to (95.05±11.22)g/L respectively (all P=0.001); The albumin of children with STAMP≤3 changed from (40.63±4.149)g/L to (41.20±5.266)g/L in treatment and that of children with STAMP≥4 changed from (40.96±8.429)g/L to (42.17±3.574)g/L in treatment(P=0.20, 0.05). Conclusion There are no obvious indications of malnutrition in children with ALL, but nearly 10 % of them have malnutrition risks. Special dietary guidance is needed during the treatment. Nutrition intervention is effective in the treatment of L-asp. Normalized data is more convenient to use in statistical analysis with more accurate results, which can be used as a supplementary method for cross-age group statistical analysis of children's height, weight and other parameters. Key words: Malnutrition; Risk screening; Evaluation; Data normalization
{"title":"Application of data normalization in the analysis and screening of the nutritional status and malnutrition risks in pediatric patients with acute lymphoblastic leukemia","authors":"Xiu-ling Yang, Jie Yan, Changlu Pan, Wenli Zhao","doi":"10.3760/CMA.J.ISSN.1674-635X.2019.02.006","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-635X.2019.02.006","url":null,"abstract":"Objective \u0000To evaluate the nutrional status and malnutrition risks of hospitalized children with acute lymphoblastic leukemia (ALL), provide nutrition support for subsequent treatment, lower nutritional risks and improve therapeutic effects; to complete the statistical analysis of height and weight across age through data normalization. \u0000 \u0000 \u0000Methods \u0000A total of 592 children diagnosed ALL from August 2014 to September 2016 at Beijing Children's Hospital were enrolled, and the directly measured height and weight which reflected the nutritional status of children were collected and normalized. Nutritional risk screening was completed by STAMP screening tool and the nutritional status was evaluated by three Z scores HAZ<-2, WAZ<-2 and WHZ<-2. The effects of nutrition intervention were investigated by weight, hemoglobin and albumin changes between before and after L-asp treatment. \u0000 \u0000 \u0000Results \u0000The Z score test showed that there was no significant difference between the nutritional status of pretreatment ALL patients(0.34% growth retardation, 2.36% lower body weight, 0.17% emaciation) and normal healthy children (3% malnutrition); after comparing the STAMP nutritional risk assessment and t test results for children with ALL, it was found that the proportion of children with high malnutrition risk ( score≥4 ) was 9.71%, which had a strong correlation with body mass index; the children with body mass index less than 0.80(50% children having malnutrition) or greater than 1.30(20% children having malnutrition) had a higher risk of malnutrition, and the body mass indexof the high-risk group(0.852 kg/m2) were significantly lower than that of the low risk group(1.051 kg/m2, score≤3 ); there were significant differences in height and weight between children with STAMP≤3 and STAMP≥4 (all P<0.05) Nutritional interventions made no significant weight change during treatment; For children with STAMP≤3 and STAMP≥4 in L-asp treatment, the hemoglobin value changed from (87.46±19.27)g/L to (95.12±13.51)g/L and (101.55±21.97)g/L to (95.05±11.22)g/L respectively (all P=0.001); The albumin of children with STAMP≤3 changed from (40.63±4.149)g/L to (41.20±5.266)g/L in treatment and that of children with STAMP≥4 changed from (40.96±8.429)g/L to (42.17±3.574)g/L in treatment(P=0.20, 0.05). \u0000 \u0000 \u0000Conclusion \u0000There are no obvious indications of malnutrition in children with ALL, but nearly 10 % of them have malnutrition risks. Special dietary guidance is needed during the treatment. Nutrition intervention is effective in the treatment of L-asp. Normalized data is more convenient to use in statistical analysis with more accurate results, which can be used as a supplementary method for cross-age group statistical analysis of children's height, weight and other parameters. \u0000 \u0000 \u0000Key words: \u0000Malnutrition; Risk screening; Evaluation; Data normalization","PeriodicalId":9877,"journal":{"name":"Chinese Journal of Clinical Nutrition","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42735500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-30DOI: 10.3760/CMA.J.ISSN.1674-635X.2019.02.004
Shukai Wu, Xiangrong Chen, Yasong Li, L. Luo
Objective To investigate the effects and mechanisms of glutamine(Gln) supplementation on oxidative stress, autophagy response and neurobehavioral outcome after traumatic brain injury (TBI) in rats. Methods TBI animal models were established using Feeney's method. Eighty SD rats were randomly divided into 4 groups: sham operation group (group Sham), Sham + glutamine supplementation group (group Sham+ GLN), traumatic brain injury group (group TBI), and TBI + glutamine supplementation group (group TBI+ GLN). We measured rat behavioral outcomes by modified neurologic severity score (mNSS) tests at day 1, 3, 7 and 14 after TBI. The apoptosis neurons in TBI cerebral cortex were determined by TUNEL staining. The expression of reactive oxygen species (ROS) was tested by ROS kits. Oxidative stress and autophagy related cytokines (HO-1, NQO1, Nrf2, LC3-Ⅱ and Beclin-1) were tested with Western blotting. Results Compared with the TBI group, the neurological function was improved[(9.79±0.43)vs.(8.43±0.30), F=6.775, P=0.010] and the apoptosis rate decreased(19.88% ±1.60% vs. 15.35% ±1.28%, P=0.013) in the TBI+ GLN group after 7-day treatment. Compared with the Sham group, the protein expression of ROS increased(P=0.000), and the expression of anti-oxidative stress factors (HO-1, NQO1) and Nrf2 pathway significantly decreased in the TBI group. After glutamine supplementation was given, the expression of ROS decreased and the expressions of HO-1 and NQO1 increased. The Nrf2 pathway and autophagy response also were activated with the expressions of Nrf2, LC3-Ⅱ and Beclin-1 increasing. Conclusion Glutamine supplementation can markedly reduce neuron apoptosis and improve neurological outcomes after TBI, thus has the protective effect on nerves by inhibiting TBI-induced oxidative stress response, activating Nrf2 pathway and autophagy response. Key words: Traumatic brain injury; Glutamine; Oxidative stress; Nrf2 pathway; Autophagy
{"title":"Neuroprotective effect of glutamine supplementation by inhibiting oxidative stress and promoting autophagy responses after traumatic brain injury in rats","authors":"Shukai Wu, Xiangrong Chen, Yasong Li, L. Luo","doi":"10.3760/CMA.J.ISSN.1674-635X.2019.02.004","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-635X.2019.02.004","url":null,"abstract":"Objective \u0000To investigate the effects and mechanisms of glutamine(Gln) supplementation on oxidative stress, autophagy response and neurobehavioral outcome after traumatic brain injury (TBI) in rats. \u0000 \u0000 \u0000Methods \u0000TBI animal models were established using Feeney's method. Eighty SD rats were randomly divided into 4 groups: sham operation group (group Sham), Sham + glutamine supplementation group (group Sham+ GLN), traumatic brain injury group (group TBI), and TBI + glutamine supplementation group (group TBI+ GLN). We measured rat behavioral outcomes by modified neurologic severity score (mNSS) tests at day 1, 3, 7 and 14 after TBI. The apoptosis neurons in TBI cerebral cortex were determined by TUNEL staining. The expression of reactive oxygen species (ROS) was tested by ROS kits. Oxidative stress and autophagy related cytokines (HO-1, NQO1, Nrf2, LC3-Ⅱ and Beclin-1) were tested with Western blotting. \u0000 \u0000 \u0000Results \u0000Compared with the TBI group, the neurological function was improved[(9.79±0.43)vs.(8.43±0.30), F=6.775, P=0.010] and the apoptosis rate decreased(19.88% ±1.60% vs. 15.35% ±1.28%, P=0.013) in the TBI+ GLN group after 7-day treatment. Compared with the Sham group, the protein expression of ROS increased(P=0.000), and the expression of anti-oxidative stress factors (HO-1, NQO1) and Nrf2 pathway significantly decreased in the TBI group. After glutamine supplementation was given, the expression of ROS decreased and the expressions of HO-1 and NQO1 increased. The Nrf2 pathway and autophagy response also were activated with the expressions of Nrf2, LC3-Ⅱ and Beclin-1 increasing. \u0000 \u0000 \u0000Conclusion \u0000Glutamine supplementation can markedly reduce neuron apoptosis and improve neurological outcomes after TBI, thus has the protective effect on nerves by inhibiting TBI-induced oxidative stress response, activating Nrf2 pathway and autophagy response. \u0000 \u0000 \u0000Key words: \u0000Traumatic brain injury; Glutamine; Oxidative stress; Nrf2 pathway; Autophagy","PeriodicalId":9877,"journal":{"name":"Chinese Journal of Clinical Nutrition","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45445832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective To investigate the regulatory effect of branched chain amino acids(BCAA) on the expression of apoptosis related proteins after cerebral ischemia reperfusion injury and the protective effects of BCAA on ischemic brain injury in rats. Methods 40 male SD rats were randomly divided into normal diet group(n=20)and branched chain amino acid (BCAA) group(n=20)according to the random number table, and each group was randomly divided into control group (n=6), sham operation group (n=6) and model group (n=8) which used suture method to make ischemia reperfusion model. After modeling, modified Neurological Severity Scores (mNSS) was used to access the neurological impairment degree of 2, 6, 24, 48 and 72 h in each group. The expression of apoptosis related proteins (Cleaved, Bax/Bcl-2) after 72 h was detected by the method of immune protein imprinting (Caspase3) and compared between normal diet group and BCAA group. Results Compared with the normal diet rats, the mNSS of BCAA diet rats after modeling at 2, 6, 24, 48, 72 h decreased(11.35±2.78 vs. 7.15±2.41, P=0.019; 9.35±1.75 vs. 5.82±1.17, P=0.002; 6.11±1.16 vs. 4.39±1.46, P=0.048; 5.87±1.32 vs. 3.55±1.94, P=0.036; 4.98±2.24 vs. 2.09±1.33, P=0.022). The expression of cleaved caspase3 protein and the ratio of Bax/Bcl-2 decreased in BCAA group. Conclusion BCAA can alleviate the apoptosis of rats after ischemia and reperfusion, reduce the damage of nerve function, and has a positive protective effect on ischemic brain injury. Key words: Branched chain amino acid; Cerebral ischemia reperfusion; Apoptosis
目的探讨支链氨基酸(BCAA)对大鼠脑缺血再灌注损伤后凋亡相关蛋白表达的调控作用及对缺血性脑损伤的保护作用。方法将40只雄性SD大鼠按随机数字表法随机分为正常饮食组(n=20)和支链氨基酸(BCAA)组(n=20)，每组随机分为对照组(n=6)、假手术组(n=6)和模型组(n=8)，采用缝合法制作缺血再灌注模型。建模完成后，采用改良神经功能严重程度评分法(mNSS)计算各组在2、6、24、48、72 h时的神经功能损害程度。采用免疫蛋白印迹法(Caspase3)检测72 h后细胞凋亡相关蛋白(Cleaved、Bax/Bcl-2)的表达，并比较正常饮食组和BCAA组的差异。结果与正常饮食大鼠比较，造模后2、6、24、48、72 h BCAA饮食大鼠的mNSS降低(11.35±2.78∶7.15±2.41,P=0.019;9.35±1.75 vs. 5.82±1.17,P=0.002;6.11±1.16 vs. 4.39±1.46,P=0.048;5.87±1.32 vs. 3.55±1.94,P=0.036;(4.98±2.24∶2.09±1.33,P=0.022)。BCAA组caspase3裂解蛋白表达降低，Bax/Bcl-2比值降低。结论BCAA能减轻大鼠缺血再灌注后的细胞凋亡，减轻神经功能损伤，对缺血性脑损伤具有积极的保护作用。关键词:支链氨基酸;脑缺血再灌注;细胞凋亡
{"title":"Effect of branched chain amino acid on apoptosis of neurons after focal cerebral ischemia in rats","authors":"F. Yan, Peng Sun, Huishou Zhao, Chong Huang, Xiong Guo, Xiaomeng Zhang","doi":"10.3760/CMA.J.ISSN.1674-635X.2019.02.010","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-635X.2019.02.010","url":null,"abstract":"Objective \u0000To investigate the regulatory effect of branched chain amino acids(BCAA) on the expression of apoptosis related proteins after cerebral ischemia reperfusion injury and the protective effects of BCAA on ischemic brain injury in rats. \u0000 \u0000 \u0000Methods \u000040 male SD rats were randomly divided into normal diet group(n=20)and branched chain amino acid (BCAA) group(n=20)according to the random number table, and each group was randomly divided into control group (n=6), sham operation group (n=6) and model group (n=8) which used suture method to make ischemia reperfusion model. After modeling, modified Neurological Severity Scores (mNSS) was used to access the neurological impairment degree of 2, 6, 24, 48 and 72 h in each group. The expression of apoptosis related proteins (Cleaved, Bax/Bcl-2) after 72 h was detected by the method of immune protein imprinting (Caspase3) and compared between normal diet group and BCAA group. \u0000 \u0000 \u0000Results \u0000Compared with the normal diet rats, the mNSS of BCAA diet rats after modeling at 2, 6, 24, 48, 72 h decreased(11.35±2.78 vs. 7.15±2.41, P=0.019; 9.35±1.75 vs. 5.82±1.17, P=0.002; 6.11±1.16 vs. 4.39±1.46, P=0.048; 5.87±1.32 vs. 3.55±1.94, P=0.036; 4.98±2.24 vs. 2.09±1.33, P=0.022). The expression of cleaved caspase3 protein and the ratio of Bax/Bcl-2 decreased in BCAA group. \u0000 \u0000 \u0000Conclusion \u0000BCAA can alleviate the apoptosis of rats after ischemia and reperfusion, reduce the damage of nerve function, and has a positive protective effect on ischemic brain injury. \u0000 \u0000 \u0000Key words: \u0000Branched chain amino acid; Cerebral ischemia reperfusion; Apoptosis","PeriodicalId":9877,"journal":{"name":"Chinese Journal of Clinical Nutrition","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45775698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-30DOI: 10.3760/CMA.J.ISSN.1674-635X.2019.02.001
Jie Pan, H. Cui, Mingwei Zhu, Wei Chen, Xin Yang, Pian-hong Zhang, X. Liang, Jianqin Sun, Yan Shi, Hong-yu Zhang, Ya-Jie Gao, Sai-nan Zhu
Objective To investigate the change of the nutritional status of elderly patients in Chinese major hospitals dynamically with nutritional risk screening 2002 (NRS 2002) and subjective global assessment (SGA) during hospitalization. Methods A prospective, multi-center survey was conducted on over 65 years old patients who were admitted in departments of gastroenterology, respiratory medicine, general surgery, geriatrics, thoracic surgery, neurology, orthopedics and medical oncology of 9 large hospitals in China for 7-30 days between June 2014 and September 2014. On admission and within 24 hours after discharge, the clinical data were recorded, physical indices were measured, and laboratory examination were conducted. NRS 2002 and SGA were used to make an evaluation. The nutritional supports and clinical outcomes were also recorded and then the correlation between nutritional status and clinical outcomes were analyzed. Results A total of 2558 patients above 65 years old were included into the study. Compared with their status on admission, their grip strength, upper arm circumference and crural circumference were reduced significantly at discharge (P<0.05). The total protein, albumin and hemoglobin levels were significantly lower than those on admission (P<0.05). The incidence of nutritional risk (NRS 2002 score≥3)and malnutrition (SGA B+ C) on admission were lower than those at discharge (51.1% vs 53.0%, 32.6% vs 35.6%). The hospitalization time and medical expenses were higher in patients with malnutrition on admission than in those with normal nutrition intakes. The nutritional status at discharge was negatively correlated with hospitalization time and medical expenses. 61.3% patients having nutritional risk did not take nutritional support during the hospital stay, while utilization rate of parenteral nutrition was higher than that of enteral nutrition in patients receiving nutritional support (19.6% vs 11.9%). Conclusion Elderly patients have higher possibilities of facing nutritional risk or malnutrition on admission, these are associated with poor clinical outcomes and their nutritional status will not improve significantly at discharge. Therefore, the screening and evaluation of nutritional status in elderly patients during hospitalization should be conducted and their nutritional intervention should be standardized so as to improve the clinical outcomes. Key words: Elderly patients; Dynamic nutrition survey; Nutritional status of discharged patients; Nutritional risk screening; Subjective global assessment; Length of hospital stay; Medical expenses
目的利用2002年营养风险筛查(NRS 2002)和主观总体评价(SGA)，动态了解我国各大医院老年患者住院期间营养状况的变化。方法对2014年6月至2014年9月在国内9家大型医院消化内科、呼吸内科、普外科、老年科、胸外科、神经内科、骨科、肿瘤内科住院7-30天的65岁以上老年患者进行前瞻性、多中心调查。入院时及出院后24小时内记录临床资料，测量体格指标，并进行实验室检查。采用NRS 2002和SGA进行评价。同时记录营养支持和临床结果，分析营养状况与临床结果的相关性。结果共纳入2558例65岁以上患者。出院时握力、上臂围、脚围较入院时明显降低(P<0.05)。总蛋白、白蛋白、血红蛋白水平均显著低于入院时(P<0.05)。入院时营养风险(NRS 2002评分≥3分)和营养不良(SGA B+ C)发生率低于出院时(51.1% vs 53.0%， 32.6% vs 35.6%)。营养不良患者入院时的住院时间和医疗费用均高于营养摄入正常的患者。出院时营养状况与住院时间、医疗费用呈负相关。61.3%有营养风险的患者在住院期间未接受营养支持，接受营养支持的患者肠外营养使用率高于肠内营养使用率(19.6% vs 11.9%)。结论老年患者入院时面临营养风险或营养不良的可能性较大，临床预后较差，出院时营养状况不会明显改善。因此，应对老年患者住院期间的营养状况进行筛查和评估，规范其营养干预，以提高临床疗效。关键词:老年患者;动态营养调查;出院患者营养状况;营养风险筛查;主观全局评价;住院时间;医疗费用
{"title":"A multicenter survey on changes in nutritional risk and malnutrition incidence of elderly patients in Chinese large hospitals during hospitalization","authors":"Jie Pan, H. Cui, Mingwei Zhu, Wei Chen, Xin Yang, Pian-hong Zhang, X. Liang, Jianqin Sun, Yan Shi, Hong-yu Zhang, Ya-Jie Gao, Sai-nan Zhu","doi":"10.3760/CMA.J.ISSN.1674-635X.2019.02.001","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-635X.2019.02.001","url":null,"abstract":"Objective \u0000To investigate the change of the nutritional status of elderly patients in Chinese major hospitals dynamically with nutritional risk screening 2002 (NRS 2002) and subjective global assessment (SGA) during hospitalization. \u0000 \u0000 \u0000Methods \u0000A prospective, multi-center survey was conducted on over 65 years old patients who were admitted in departments of gastroenterology, respiratory medicine, general surgery, geriatrics, thoracic surgery, neurology, orthopedics and medical oncology of 9 large hospitals in China for 7-30 days between June 2014 and September 2014. On admission and within 24 hours after discharge, the clinical data were recorded, physical indices were measured, and laboratory examination were conducted. NRS 2002 and SGA were used to make an evaluation. The nutritional supports and clinical outcomes were also recorded and then the correlation between nutritional status and clinical outcomes were analyzed. \u0000 \u0000 \u0000Results \u0000A total of 2558 patients above 65 years old were included into the study. Compared with their status on admission, their grip strength, upper arm circumference and crural circumference were reduced significantly at discharge (P<0.05). The total protein, albumin and hemoglobin levels were significantly lower than those on admission (P<0.05). The incidence of nutritional risk (NRS 2002 score≥3)and malnutrition (SGA B+ C) on admission were lower than those at discharge (51.1% vs 53.0%, 32.6% vs 35.6%). The hospitalization time and medical expenses were higher in patients with malnutrition on admission than in those with normal nutrition intakes. The nutritional status at discharge was negatively correlated with hospitalization time and medical expenses. 61.3% patients having nutritional risk did not take nutritional support during the hospital stay, while utilization rate of parenteral nutrition was higher than that of enteral nutrition in patients receiving nutritional support (19.6% vs 11.9%). \u0000 \u0000 \u0000Conclusion \u0000Elderly patients have higher possibilities of facing nutritional risk or malnutrition on admission, these are associated with poor clinical outcomes and their nutritional status will not improve significantly at discharge. Therefore, the screening and evaluation of nutritional status in elderly patients during hospitalization should be conducted and their nutritional intervention should be standardized so as to improve the clinical outcomes. \u0000 \u0000 \u0000Key words: \u0000Elderly patients; Dynamic nutrition survey; Nutritional status of discharged patients; Nutritional risk screening; Subjective global assessment; Length of hospital stay; Medical expenses","PeriodicalId":9877,"journal":{"name":"Chinese Journal of Clinical Nutrition","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43110703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-30DOI: 10.3760/CMA.J.ISSN.1674-635X.2019.02.007
Ge Jin, Xiang Liu, Runxiang Xie, Zixuan Guo, Yue Sun, Tianyu Liu, Bangmao Wang
Objective To investigate the effects of Lactobacillus rhamnosus GG (LGG) colonization in early life on intestinal barrier and intestinal development in offspring mice and its possible mechanism. Methods Six C57BL/6 pregnant mice with the same conception time of 6 weeks were selected and randomly divided into experiment group given 108 cfu/ml LGG live bacteria and control group given LGG inactivated bacteria by gavage from the 18th day of pregnancy until natural birth. The progeny mice in the two groups were continued to be gavaged with 107 cfu/ml of LGG live bacteria or LGG inactivated bacteria on days 1-5 of birth. The body weight changes of 3 week'progeny mice were recorded. The colonization of LGG bacteria in offspring mice was detected at 2nd and 3rd weeks. The mRNA of intestinal proinflammatory cytokines and tight junction molecules were evaluated by real-time PCR method. HE, immunohistochemistry, immunofluorescence staining and enzyme-linked immunosorbent assay were used to evaluate the intestinal barrier of 3-week old off spring mice. Results Compared with the control group, the progeny mice of the experiment group showed no significant difference in body weight at the first week, and the body weight increased at the second week and the third week [2nd week: (3.790±0.240)g vs.(4.326±0.140)g, t=3.707, P=0.006; 3rd week: (7.295±0.326)g vs. (8.040±0.370)g, t=3.130, P=0.011]. LGG colonization can be detected only in the feces of progeny mice in the experiment group. Intestinal colonization can promote the growth of small intestine villi and colon crypt depth[jejunum: (320.000±22.514)μm vs.(265.100±15.611)μm, t=8.258, P<0.001; ileum: (150.500±13.099)μm vs.(111.000±11.308)μm, t=9.958, P<0.001; colon: (295.000±15.209)μm vs.(233.100±6.678)μm, t=9.129, P<0.001]. Compared with the control group, the number of goblet cells in the colonic crypt of the experiment group increased(11.62±0.780 vs. 35.24 ±1.370, t=15.000, P<0.001), and the relative mRNA expression levels of pro-inflammatory factors as IFN-γ (1.280±0.232 vs. 0.512±0.206, t=4.970, P=0.001), IL-6(1.364±0.271 vs. 0.941±0.215, t=2.452, P=0.040), IL-10(1.341±0.320 vs. 0.744±0.294, t=2.762, P=0.025) and TNF-α(3.702±0.150 vs. 2.581±0.500, t=2.553, P=0.034) in the experiment group decreased; the expression levels of the intimate tight junction molecules (Claudin3)(1.283±0.152 vs. 1.881±0.172, t=4.932, P=0.001)and the atresia protein molecule (Occludin)( 1.164±0.342 vs. 0.812±0.224, t=3.67, P=0.016) significantly increased. Conclusion Early life LGG colonization protects the intestinal barrier by inhibiting low-grade intestinal inflammation. This study will lay the experimental foundation for the supplementation of probiotics in early life so as to prevent intestinal diseases. Key words: Early life; Lactobacillus rhamnosus GG; Low-grade inflammation; Intestinal barrier
目的探讨鼠李糖乳杆菌GG (Lactobacillus rhamnosus GG, LGG)早期定殖对子代小鼠肠道屏障和肠道发育的影响及其可能的机制。方法选择6周相同受胎时间的C57BL/6妊娠小鼠6只，从妊娠第18天起至自然分娩，随机分为试验组给予LGG活菌108 cfu/ml，对照组给予LGG灭活菌灌胃。两组子代小鼠在出生后第1-5天继续以107 cfu/ml的LGG活菌或LGG灭活菌灌胃。记录3周子代小鼠的体重变化。在第2周和第3周检测LGG细菌在子代小鼠中的定殖。实时荧光定量PCR法检测肠道促炎细胞因子和紧密连接分子mRNA表达水平。采用HE法、免疫组织化学法、免疫荧光染色法和酶联免疫吸附法对3周龄春小鼠肠道屏障进行评价。结果与对照组相比，实验组子代小鼠第1周体重差异无统计学意义，第2周和第3周体重增加[第2周:(3.790±0.240)g vs(4.326±0.140)g, t=3.707, P=0.006;第三周:g(7.295±0.326)和(8.040±0.370)g, t = 3.130, P = 0.011)。实验组仅在子代小鼠粪便中检测到LGG定殖。肠道定殖可促进小肠绒毛和结肠隐窝深度的生长[空肠:(320.000±22.514)μm vs(265.100±15.611)μm, t=8.258, P<0.001];回肠:μm(150.500±13.099)和(111.000±11.308)μm, t = 9.958, P < 0.001;结肠:μm(295.000±15.209)和(233.100±6.678)μm, t = 9.129, P < 0.001)。与对照组相比，实验组结肠隐窝杯状细胞数量增加(11.62±0.780 vs. 35.24±1.370,t=15.000, P<0.001)，促炎因子IFN-γ(1.280±0.232 vs. 0.512±0.206,t=4.970, P=0.001)、IL-6(1.364±0.271 vs. 0.941±0.215,t=2.452, P=0.040)、IL-10(1.341±0.320 vs. 0.744±0.294,t=2.762, P=0.025)、TNF-α(3.702±0.150 vs. 2.581±0.500,t=2.553, P=0.034) mRNA相对表达量降低;亲密紧密连接分子(Claudin3)(1.283±0.152比1.881±0.172,t=4.932, P=0.001)和闭锁蛋白分子(Occludin)(1.164±0.342比0.812±0.224,t=3.67, P=0.016)的表达水平显著升高。结论生命早期LGG定殖通过抑制低级别肠道炎症来保护肠道屏障。本研究将为生命早期补充益生菌以预防肠道疾病奠定实验基础。关键词:早期生活;鼠李糖乳杆菌GG;慢性炎症;肠屏障
{"title":"Protection effect of Lactobacillus rhamnosus GG supplied in early life on intestinal barrier in offspring","authors":"Ge Jin, Xiang Liu, Runxiang Xie, Zixuan Guo, Yue Sun, Tianyu Liu, Bangmao Wang","doi":"10.3760/CMA.J.ISSN.1674-635X.2019.02.007","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-635X.2019.02.007","url":null,"abstract":"Objective \u0000To investigate the effects of Lactobacillus rhamnosus GG (LGG) colonization in early life on intestinal barrier and intestinal development in offspring mice and its possible mechanism. \u0000 \u0000 \u0000Methods \u0000Six C57BL/6 pregnant mice with the same conception time of 6 weeks were selected and randomly divided into experiment group given 108 cfu/ml LGG live bacteria and control group given LGG inactivated bacteria by gavage from the 18th day of pregnancy until natural birth. The progeny mice in the two groups were continued to be gavaged with 107 cfu/ml of LGG live bacteria or LGG inactivated bacteria on days 1-5 of birth. The body weight changes of 3 week'progeny mice were recorded. The colonization of LGG bacteria in offspring mice was detected at 2nd and 3rd weeks. The mRNA of intestinal proinflammatory cytokines and tight junction molecules were evaluated by real-time PCR method. HE, immunohistochemistry, immunofluorescence staining and enzyme-linked immunosorbent assay were used to evaluate the intestinal barrier of 3-week old off spring mice. \u0000 \u0000 \u0000Results \u0000Compared with the control group, the progeny mice of the experiment group showed no significant difference in body weight at the first week, and the body weight increased at the second week and the third week [2nd week: (3.790±0.240)g vs.(4.326±0.140)g, t=3.707, P=0.006; 3rd week: (7.295±0.326)g vs. (8.040±0.370)g, t=3.130, P=0.011]. LGG colonization can be detected only in the feces of progeny mice in the experiment group. Intestinal colonization can promote the growth of small intestine villi and colon crypt depth[jejunum: (320.000±22.514)μm vs.(265.100±15.611)μm, t=8.258, P<0.001; ileum: (150.500±13.099)μm vs.(111.000±11.308)μm, t=9.958, P<0.001; colon: (295.000±15.209)μm vs.(233.100±6.678)μm, t=9.129, P<0.001]. Compared with the control group, the number of goblet cells in the colonic crypt of the experiment group increased(11.62±0.780 vs. 35.24 ±1.370, t=15.000, P<0.001), and the relative mRNA expression levels of pro-inflammatory factors as IFN-γ (1.280±0.232 vs. 0.512±0.206, t=4.970, P=0.001), IL-6(1.364±0.271 vs. 0.941±0.215, t=2.452, P=0.040), IL-10(1.341±0.320 vs. 0.744±0.294, t=2.762, P=0.025) and TNF-α(3.702±0.150 vs. 2.581±0.500, t=2.553, P=0.034) in the experiment group decreased; the expression levels of the intimate tight junction molecules (Claudin3)(1.283±0.152 vs. 1.881±0.172, t=4.932, P=0.001)and the atresia protein molecule (Occludin)( 1.164±0.342 vs. 0.812±0.224, t=3.67, P=0.016) significantly increased. \u0000 \u0000 \u0000Conclusion \u0000Early life LGG colonization protects the intestinal barrier by inhibiting low-grade intestinal inflammation. This study will lay the experimental foundation for the supplementation of probiotics in early life so as to prevent intestinal diseases. \u0000 \u0000 \u0000Key words: \u0000Early life; Lactobacillus rhamnosus GG; Low-grade inflammation; Intestinal barrier","PeriodicalId":9877,"journal":{"name":"Chinese Journal of Clinical Nutrition","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43501507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-02-28DOI: 10.3760/CMA.J.ISSN.1674-635X.2019.01.001
Jian Yang, Zhuming Jiang, Kang Yu
The criteria for malnutrition assessment (diagnosis) have been developed for years. Global Leadership Initiative on Malnutrition (GLIM) criteria for the diagnosis of malnutrition was issued in September 2018, which aims to build a global consensus around core diagnostic criteria for adult malnutrition in clinical settings. In this article, GLIM malnutrition assessment (diagnosis) consensus was reviewed and analyzed. Key words: Malnutrition; Nutritional screening; Nutritional risk screening; Nutrition support therapy
{"title":"Explanation and analysis on GLIM consensus (2018) for malnutrition assessment (diagnosis)","authors":"Jian Yang, Zhuming Jiang, Kang Yu","doi":"10.3760/CMA.J.ISSN.1674-635X.2019.01.001","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-635X.2019.01.001","url":null,"abstract":"The criteria for malnutrition assessment (diagnosis) have been developed for years. Global Leadership Initiative on Malnutrition (GLIM) criteria for the diagnosis of malnutrition was issued in September 2018, which aims to build a global consensus around core diagnostic criteria for adult malnutrition in clinical settings. In this article, GLIM malnutrition assessment (diagnosis) consensus was reviewed and analyzed. \u0000 \u0000 \u0000Key words: \u0000Malnutrition; Nutritional screening; Nutritional risk screening; Nutrition support therapy","PeriodicalId":9877,"journal":{"name":"Chinese Journal of Clinical Nutrition","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47081273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-02-28DOI: 10.3760/CMA.J.ISSN.1674-635X.2019.01.003
Ma Liya, Yue-ming He, Liu Quanyan, Zhang Zhonglin, Pan Dingyu, Yuan Yufeng, Liu Zhi-su
Objective To explore the effect of fish oil fat emulsion as perioperative nutritional support on patients with liver cirrhosis and portal hypertension. Methods Randomized controlled clinical trial was performed between September 2011 and September 2017 in patients with liver cirrhosis and portal hypertension who underwent pericardial devascularization and splenectomy. Hypocaloric total parenteral nutritional support (TPN) started from the first day after the operation for 5 consecutive days. Patients were divided into experimental group and control group according to the type of fat emulsion used. 43 patients in experimental group were applied for fish oil fat emulsion injection (10% Omegaven) + medium long chain structure fat emulsion (20% STG) and 42 patients in control group were applied for medium long chain structure fat emulsion(20%STG). Liver function (total bilirubin and alanine aminotransferase), nutrition index (serum albumin and prealbumin), inflammatory mediators (TNF-ɑ, IL-6 and IL-10) were measured before and after the operation, and the clinical outcomes were observed. Results There was no statistically significant difference in liver function and nutritional indices between the experimental group and the control group (P>0.05). The inflammatory mediators like TNF-ɑ, IL-6 and IL-10 on the first day after surgery were significantly higher than those before surgery in both groups [experiment group: (225.54±54.78)vs.(61.49±16.47), (74.94±6.36)vs. (39.84±2.77), (77.53±11.4) vs. (46.05±6.13)ng/L ; control group: (229.26±62.15)vs.(63.48±13.76), (77.23±7.83) vs.(40.64±3.34), (73.89±7.97)vs.(44.88±5.72)ng/L ; P< 0.01]. With the progress of time, the proinflammatory factors like TNF-ɑ and IL-6 decreased after the operation and the range of decrease was higher in experiment group than in control group[d4-d1: (-56.88±31.63)vs.(-35.96±20.02), (-13.52±5.20)vs.(-6.38±2.84)ng/L; d7-d1: (-150.67±42.58)vs.(-132.79±53.35), (-27.04±8.97)vs.(-20.85±6.38)ng/L; P< 0.05]. The range of increase in anti-inflammatory media IL-10 was higher in experiment group than in the control group(d4-d1: (14.22±13.08)vs. (5.64±3.58)ng/L ; d7-d1: (17.78±5.58)vs. (-37.96±11.43)ng/L ; P<0.05). The incidence of grade Ⅲ complications and total complications (4.7% vs. 21.4%, 23.3% vs. 45.2%) and hospitalization time [(10.12 ±1.48) vs. (12.33±2.04) d] in the experimental group were significantly lower than those in the control group (P<0. 05). Conclusions In patients with liver cirrhosis and portal hypertension, perioperative nutritional support of fish oil fat emulsion can reduce systemic inflammatory response and operative complications and promote rapid recovery through its two-way regulation of inflammatory mediators. Key words: Fish oil fat emulsion; Inflammation mediators; Liver cirrhosis; Portal hypertension; Perioperative nutritional support
{"title":"Fish oil fat emulsion nutritional support in the treatment of liver cirrhosis and portal hypertension in patients with pericardial devascularization with splenectomy: A randomized clinical trial","authors":"Ma Liya, Yue-ming He, Liu Quanyan, Zhang Zhonglin, Pan Dingyu, Yuan Yufeng, Liu Zhi-su","doi":"10.3760/CMA.J.ISSN.1674-635X.2019.01.003","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-635X.2019.01.003","url":null,"abstract":"Objective \u0000To explore the effect of fish oil fat emulsion as perioperative nutritional support on patients with liver cirrhosis and portal hypertension. \u0000 \u0000 \u0000Methods \u0000Randomized controlled clinical trial was performed between September 2011 and September 2017 in patients with liver cirrhosis and portal hypertension who underwent pericardial devascularization and splenectomy. Hypocaloric total parenteral nutritional support (TPN) started from the first day after the operation for 5 consecutive days. Patients were divided into experimental group and control group according to the type of fat emulsion used. 43 patients in experimental group were applied for fish oil fat emulsion injection (10% Omegaven) + medium long chain structure fat emulsion (20% STG) and 42 patients in control group were applied for medium long chain structure fat emulsion(20%STG). Liver function (total bilirubin and alanine aminotransferase), nutrition index (serum albumin and prealbumin), inflammatory mediators (TNF-ɑ, IL-6 and IL-10) were measured before and after the operation, and the clinical outcomes were observed. \u0000 \u0000 \u0000Results \u0000There was no statistically significant difference in liver function and nutritional indices between the experimental group and the control group (P>0.05). The inflammatory mediators like TNF-ɑ, IL-6 and IL-10 on the first day after surgery were significantly higher than those before surgery in both groups [experiment group: (225.54±54.78)vs.(61.49±16.47), (74.94±6.36)vs. (39.84±2.77), (77.53±11.4) vs. (46.05±6.13)ng/L ; control group: (229.26±62.15)vs.(63.48±13.76), (77.23±7.83) vs.(40.64±3.34), (73.89±7.97)vs.(44.88±5.72)ng/L ; P< 0.01]. With the progress of time, the proinflammatory factors like TNF-ɑ and IL-6 decreased after the operation and the range of decrease was higher in experiment group than in control group[d4-d1: (-56.88±31.63)vs.(-35.96±20.02), (-13.52±5.20)vs.(-6.38±2.84)ng/L; d7-d1: (-150.67±42.58)vs.(-132.79±53.35), (-27.04±8.97)vs.(-20.85±6.38)ng/L; P< 0.05]. The range of increase in anti-inflammatory media IL-10 was higher in experiment group than in the control group(d4-d1: (14.22±13.08)vs. (5.64±3.58)ng/L ; d7-d1: (17.78±5.58)vs. (-37.96±11.43)ng/L ; P<0.05). The incidence of grade Ⅲ complications and total complications (4.7% vs. 21.4%, 23.3% vs. 45.2%) and hospitalization time [(10.12 ±1.48) vs. (12.33±2.04) d] in the experimental group were significantly lower than those in the control group (P<0. 05). \u0000 \u0000 \u0000Conclusions \u0000In patients with liver cirrhosis and portal hypertension, perioperative nutritional support of fish oil fat emulsion can reduce systemic inflammatory response and operative complications and promote rapid recovery through its two-way regulation of inflammatory mediators. \u0000 \u0000 \u0000Key words: \u0000Fish oil fat emulsion; Inflammation mediators; Liver cirrhosis; Portal hypertension; Perioperative nutritional support","PeriodicalId":9877,"journal":{"name":"Chinese Journal of Clinical Nutrition","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46891338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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