Pub Date : 2019-08-30DOI: 10.3760/CMA.J.ISSN.1674-635X.2019.04.009
Bingbin Zhao, Lei Zhang
Osteoporosis is a global public health problem. The kidney, especially the Na-Cl co-transporter (NCC) located in the renal distal tubular cells, which is an important transporter for urinary calcium regulation, plays an important role in calcium homeostasis and bone metabolism. This review summarized recent researches on effects and mechanisms of NCC on calcium and bone metabolism. Key words: Na-Cl co-transporter; Calcium homeostasis; Bone metabolism
{"title":"Effects of renal Na-Cl co-transporter on calcium homeostasis and bone metabolism","authors":"Bingbin Zhao, Lei Zhang","doi":"10.3760/CMA.J.ISSN.1674-635X.2019.04.009","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-635X.2019.04.009","url":null,"abstract":"Osteoporosis is a global public health problem. The kidney, especially the Na-Cl co-transporter (NCC) located in the renal distal tubular cells, which is an important transporter for urinary calcium regulation, plays an important role in calcium homeostasis and bone metabolism. This review summarized recent researches on effects and mechanisms of NCC on calcium and bone metabolism. \u0000 \u0000 \u0000Key words: \u0000Na-Cl co-transporter; Calcium homeostasis; Bone metabolism","PeriodicalId":9877,"journal":{"name":"Chinese Journal of Clinical Nutrition","volume":"27 1","pages":"251-256"},"PeriodicalIF":0.0,"publicationDate":"2019-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44607372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-30DOI: 10.3760/CMA.J.ISSN.1674-635X.2019.04.004
Zhuo Li, Yan-Hua Liu, Jun Chen, Shao-dong Zhao, Jirong Qi, H. Miao
Objective To investigate the influencing factors for energy balance and the relationship between energy balance and clinical outcome in PICU mechanical ventilation children. Methods Children with mechanical ventilation who were hospitalized in PICU for more than 3 days from June 2015 to May 2016 were collected, resting energy expenditure was measured by resting energy metabolic detector, and the nutrition balance was calculated, the influencing factors on energy balance was analyzed by regression analysis. Results A total of 104 mechanical ventilation children were included with the average energy consumption of (265.4±63.2)kJ/kg in the first 3 days and the average energy supply of (219.8±82.9)kJ/kg, and failed to reach the target value (P<0.05). As the time of hospitalization was prolonged, the supply of energy increased gradually, the SAPS Ⅱ (r=-0.609, P=0.000), mechanical ventilation time (r=-0.456, P=0.000), ICU stay time (r=-0.646, P=0.000), the number of organ failure(r=-0.568, P=0.000), infection complications (r=-0.859, P=0.000) were negatively correlated to energy supply balance; regression analysis showed that complications of nosocomial infection (P=0.000), number of organ failure (P=0.000), mechanical ventilation time (P=0.000), ICU retention time (P=0.001) were predictors of energy supply balance. Conclusion Insufficient supply of energy for the first three days of mechanical ventilation is high in the critically ill children. Factors affecting energy supply balance include patient's organ failure, infection complications, mechanical ventilation time, and ICU retention time, which suggest that the strengthening of the nutritional management of the critically ill children with mechanical ventilation will benefit to the clinical outcome. Key words: Nutritional risk; Resting energy; Mechanical ventilation; Energy balance
{"title":"Energy balance and prognosis of children with mechanical ventilation in pediatric intensive care unit","authors":"Zhuo Li, Yan-Hua Liu, Jun Chen, Shao-dong Zhao, Jirong Qi, H. Miao","doi":"10.3760/CMA.J.ISSN.1674-635X.2019.04.004","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-635X.2019.04.004","url":null,"abstract":"Objective \u0000To investigate the influencing factors for energy balance and the relationship between energy balance and clinical outcome in PICU mechanical ventilation children. \u0000 \u0000 \u0000Methods \u0000Children with mechanical ventilation who were hospitalized in PICU for more than 3 days from June 2015 to May 2016 were collected, resting energy expenditure was measured by resting energy metabolic detector, and the nutrition balance was calculated, the influencing factors on energy balance was analyzed by regression analysis. \u0000 \u0000 \u0000Results \u0000A total of 104 mechanical ventilation children were included with the average energy consumption of (265.4±63.2)kJ/kg in the first 3 days and the average energy supply of (219.8±82.9)kJ/kg, and failed to reach the target value (P<0.05). As the time of hospitalization was prolonged, the supply of energy increased gradually, the SAPS Ⅱ (r=-0.609, P=0.000), mechanical ventilation time (r=-0.456, P=0.000), ICU stay time (r=-0.646, P=0.000), the number of organ failure(r=-0.568, P=0.000), infection complications (r=-0.859, P=0.000) were negatively correlated to energy supply balance; regression analysis showed that complications of nosocomial infection (P=0.000), number of organ failure (P=0.000), mechanical ventilation time (P=0.000), ICU retention time (P=0.001) were predictors of energy supply balance. \u0000 \u0000 \u0000Conclusion \u0000Insufficient supply of energy for the first three days of mechanical ventilation is high in the critically ill children. Factors affecting energy supply balance include patient's organ failure, infection complications, mechanical ventilation time, and ICU retention time, which suggest that the strengthening of the nutritional management of the critically ill children with mechanical ventilation will benefit to the clinical outcome. \u0000 \u0000 \u0000Key words: \u0000Nutritional risk; Resting energy; Mechanical ventilation; Energy balance","PeriodicalId":9877,"journal":{"name":"Chinese Journal of Clinical Nutrition","volume":"27 1","pages":"221-226"},"PeriodicalIF":0.0,"publicationDate":"2019-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41609910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-30DOI: 10.3760/CMA.J.ISSN.1674-635X.2019.04.008
M. Ye
The burden of cardiovascular disease in China is severe and keep increasing nowadays, while effective dietary management strategies play an important role in its primary prevention and treatment. Flaxseed is rich in lots of bioactive components like α-linolenic acid, lignan, linseed bioactive protein fragments and fiber, which can effectively improve a variety of heart risk factors like atherosclerosis, obesity and abnormal blood glucose, and thus has become a hot spot in researches of dietary strategies for cardiovascular diseases. As a potential heart-friendly food, cardiovascular-protective effects of flaxseed are particularly prominent in blood pressure control and lipid regulation. This article reviewed recent clinical controlled trials studying effects of flaxseed on both blood pressure and lipid profiles in different populations, and its potential hypotensive as well as lipid-lowering mechanisms, in order to lay a solid foundation for further studies. Key words: Flaxseed; Blood pressure; Blood Lipids
{"title":"Progress of clinical trials about effects of flaxseed in blood pressure and lipid profiles","authors":"M. Ye","doi":"10.3760/CMA.J.ISSN.1674-635X.2019.04.008","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-635X.2019.04.008","url":null,"abstract":"The burden of cardiovascular disease in China is severe and keep increasing nowadays, while effective dietary management strategies play an important role in its primary prevention and treatment. Flaxseed is rich in lots of bioactive components like α-linolenic acid, lignan, linseed bioactive protein fragments and fiber, which can effectively improve a variety of heart risk factors like atherosclerosis, obesity and abnormal blood glucose, and thus has become a hot spot in researches of dietary strategies for cardiovascular diseases. As a potential heart-friendly food, cardiovascular-protective effects of flaxseed are particularly prominent in blood pressure control and lipid regulation. This article reviewed recent clinical controlled trials studying effects of flaxseed on both blood pressure and lipid profiles in different populations, and its potential hypotensive as well as lipid-lowering mechanisms, in order to lay a solid foundation for further studies. \u0000 \u0000 \u0000Key words: \u0000Flaxseed; Blood pressure; Blood Lipids","PeriodicalId":9877,"journal":{"name":"Chinese Journal of Clinical Nutrition","volume":"27 1","pages":"247-250"},"PeriodicalIF":0.0,"publicationDate":"2019-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46915183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-30DOI: 10.3760/CMA.J.ISSN.1674-635X.2019.04.001
Yingying Su, Suyue Pan, Bin Pen, Wen Jiang, Furong Wang, Le Zhang, Xu Zhang, Liang Ding, Meng Zhang, Fang Cui
As clinical research goes deep, new research evidence emerges continuously. In order to maintain the timeliness and advancement of the consensus, we have revised the Consensus on Nutritional Support for Neurological Diseases, issued in 2011, including 3 new evidences, 3 revised evidence levels according to the latest evidence level standards, 1 new recommendation and 1 revised recommendation. In addition, we have revised the Consensus on the Operational Standards of Nutritional Support for Neurological Diseases, issued in 2011, including 9 new evidences, 2 updated evidences, 7 revised evidence levels according to the latest evidence level standards, 4 new recommendations, 3 updated recommendations and 2 revised recommendations. In order to comprehensively and systematically reflect the management and regulation of nutritional support for neurological disease, we have merged the two consensuses.
{"title":"Chinese expert consensus on enteral nutrition support for neurological diseases (the second version)","authors":"Yingying Su, Suyue Pan, Bin Pen, Wen Jiang, Furong Wang, Le Zhang, Xu Zhang, Liang Ding, Meng Zhang, Fang Cui","doi":"10.3760/CMA.J.ISSN.1674-635X.2019.04.001","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-635X.2019.04.001","url":null,"abstract":"As clinical research goes deep, new research evidence emerges continuously. In order to maintain the timeliness and advancement of the consensus, we have revised the Consensus on Nutritional Support for Neurological Diseases, issued in 2011, including 3 new evidences, 3 revised evidence levels according to the latest evidence level standards, 1 new recommendation and 1 revised recommendation. In addition, we have revised the Consensus on the Operational Standards of Nutritional Support for Neurological Diseases, issued in 2011, including 9 new evidences, 2 updated evidences, 7 revised evidence levels according to the latest evidence level standards, 4 new recommendations, 3 updated recommendations and 2 revised recommendations. In order to comprehensively and systematically reflect the management and regulation of nutritional support for neurological disease, we have merged the two consensuses.","PeriodicalId":9877,"journal":{"name":"Chinese Journal of Clinical Nutrition","volume":"27 1","pages":"193-203"},"PeriodicalIF":0.0,"publicationDate":"2019-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42515238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-30DOI: 10.3760/CMA.J.ISSN.1674-635X.2019.04.003
Yu Bai, Lei Tang
Objective To systematically evaluate the effects of vitamin D supplementation on glucose homeostasis parameters and lipid profiles in gestational diabetes patients. Methods Four main databases including PubMed, Web of Science, CNKI and Wanfang were searched to collect randomized controlled trials (RCTs) about vitamin D supplementation for gestational diabetes mellitus from inception to February 1, 2018.Two investigators were chosen to search, extract and evaluate the data independently. Software RevMan 5.3 and Stata 15.0 were used for meta-analysis. Results Results A total of 6 randomized RCTs were included including 409 patients totally which were divided into two groups as study group(n=204) and control group(n=205). The results showed that compared with the control group, patients in study group had lower fasting plasma glucose(FPG)[MD=-11.43, 95% CI=(-15.24-7.61), P=0.000 01], fasting insulin(FIns)[MD=-4.8, 95% CI=(-5.99, 3.62), P<0.000 01], insulin homeostasis model assessment of insulin resistance(HOMA-IR)[MD=-1.48, 95% CI=(-1.81, 1.16), P<0.000 01], total-cholesterol(TC)[MD=-14.09, 95% CI=(-22.09, 5.2), P=0.002], low-density lipoprotein(LDL)[MD=-10.54, 95% CI=(-18.18, 2.89), P=0.007] and high-density lipoprotein(HDL)[MD=2.11, 95% CI=(0.36, 3.86), P=0.02]. No significant difference was found in triglycerides level(TG) between the two groups. Conclusion Vitamin D supplementation in patients with gestational diabetes can improve FPG, insulin, TC, LDL, insulin resistance and HDL, but has no effect on TG. Key words: Vitamin D; Gestational diabetes mellitus; Meta-analysis; Randomized controlled trials
{"title":"Effects of vitamin D supplementation on glycaemic control and lipid profiles in gestational diabetes mellitus: a Meta-analysis of randomized controlled trials","authors":"Yu Bai, Lei Tang","doi":"10.3760/CMA.J.ISSN.1674-635X.2019.04.003","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-635X.2019.04.003","url":null,"abstract":"Objective \u0000To systematically evaluate the effects of vitamin D supplementation on glucose homeostasis parameters and lipid profiles in gestational diabetes patients. \u0000 \u0000 \u0000Methods \u0000Four main databases including PubMed, Web of Science, CNKI and Wanfang were searched to collect randomized controlled trials (RCTs) about vitamin D supplementation for gestational diabetes mellitus from inception to February 1, 2018.Two investigators were chosen to search, extract and evaluate the data independently. Software RevMan 5.3 and Stata 15.0 were used for meta-analysis. \u0000 \u0000 \u0000Results \u0000Results A total of 6 randomized RCTs were included including 409 patients totally which were divided into two groups as study group(n=204) and control group(n=205). The results showed that compared with the control group, patients in study group had lower fasting plasma glucose(FPG)[MD=-11.43, 95% CI=(-15.24-7.61), P=0.000 01], fasting insulin(FIns)[MD=-4.8, 95% CI=(-5.99, 3.62), P<0.000 01], insulin homeostasis model assessment of insulin resistance(HOMA-IR)[MD=-1.48, 95% CI=(-1.81, 1.16), P<0.000 01], total-cholesterol(TC)[MD=-14.09, 95% CI=(-22.09, 5.2), P=0.002], low-density lipoprotein(LDL)[MD=-10.54, 95% CI=(-18.18, 2.89), P=0.007] and high-density lipoprotein(HDL)[MD=2.11, 95% CI=(0.36, 3.86), P=0.02]. No significant difference was found in triglycerides level(TG) between the two groups. \u0000 \u0000 \u0000Conclusion \u0000Vitamin D supplementation in patients with gestational diabetes can improve FPG, insulin, TC, LDL, insulin resistance and HDL, but has no effect on TG. \u0000 \u0000 \u0000Key words: \u0000Vitamin D; Gestational diabetes mellitus; Meta-analysis; Randomized controlled trials","PeriodicalId":9877,"journal":{"name":"Chinese Journal of Clinical Nutrition","volume":"27 1","pages":"213-220"},"PeriodicalIF":0.0,"publicationDate":"2019-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41468543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-30DOI: 10.3760/CMA.J.ISSN.1674-635X.2019.04.006
Dan Zhang, Yanqin Lu, S. Pan
Objective To investigate the incidence of nutritional risk in infants with lower respiratory tract infection, and to compare the effects of different nutritional risks on clinical outcomes, and to provide evidence for clinical nutritional management of infantile lower respiratory tract infection. Methods Infants and young children with lower respiratory tract infection who were hospitalized in our hospital from January 2013 to March 2016 were selected as subjects. Nutritional risk screening was performed using the Nutritional Status and Growth Risk Screening Tool (STRONGkids). Results A total of 957 infants with lower respiratory tract infections were included in the study. The incidence of high nutrition risk and low and medium nutritional risk were 17.6% and 82.4%, respectively. The clinical cure rate was 68.5% and 71.4% respectively. The children with pneumonia and bronchitis had high nutritional risk. The incidence rates were 20.60% and 4.87%, respectively, and the difference was statistically significant (χ2=25.52, P=0.000). Time-effect single factor analysis (Kaplan-Meier method): The hospitalization time for infants with low nutritional risk and high nutritional risk was 9.3(0.3) d and 13.3(1.0) d, respectively. The difference between the two groups was statistically significant. (χ2=28.33, P=0.000), the total hospitalization expenses were 5 653.5(224.8) yuan and 10 079.5(1 755.8) yuan respectively. The difference between the two groups was statistically significant (χ2=4.47, P=0.034). Multivariate COX regression analysis: High nutritional risk was a risk factor for hospitalization of hospitalized infants with lower respiratory tract infection (RR=1.57, P=0.024). Conclusion There is a high incidence of high nutritional risk in infants with lower respiratory tract infection. Compared with children with low and moderate nutritional risk, the hospitalization time is longer, the hospitalization cost is increased, and the clinical cure rate is lower, which is the risk of clinical outcome. factor. Therefore, it is necessary to conduct nutrition risk screening for infants with lower respiratory tract infections, and provide a theoretical basis for clinical nutrition evaluation and nutritional intervention. Key words: Respiratory infections; Infants; Nutritional status and growth risk screening tools
{"title":"Application of STRONGkids to screen infants with lower respiratory tract infection and its possible influence on clinical outcome","authors":"Dan Zhang, Yanqin Lu, S. Pan","doi":"10.3760/CMA.J.ISSN.1674-635X.2019.04.006","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-635X.2019.04.006","url":null,"abstract":"Objective \u0000To investigate the incidence of nutritional risk in infants with lower respiratory tract infection, and to compare the effects of different nutritional risks on clinical outcomes, and to provide evidence for clinical nutritional management of infantile lower respiratory tract infection. \u0000 \u0000 \u0000Methods \u0000Infants and young children with lower respiratory tract infection who were hospitalized in our hospital from January 2013 to March 2016 were selected as subjects. Nutritional risk screening was performed using the Nutritional Status and Growth Risk Screening Tool (STRONGkids). \u0000 \u0000 \u0000Results \u0000A total of 957 infants with lower respiratory tract infections were included in the study. The incidence of high nutrition risk and low and medium nutritional risk were 17.6% and 82.4%, respectively. The clinical cure rate was 68.5% and 71.4% respectively. The children with pneumonia and bronchitis had high nutritional risk. The incidence rates were 20.60% and 4.87%, respectively, and the difference was statistically significant (χ2=25.52, P=0.000). Time-effect single factor analysis (Kaplan-Meier method): The hospitalization time for infants with low nutritional risk and high nutritional risk was 9.3(0.3) d and 13.3(1.0) d, respectively. The difference between the two groups was statistically significant. (χ2=28.33, P=0.000), the total hospitalization expenses were 5 653.5(224.8) yuan and 10 079.5(1 755.8) yuan respectively. The difference between the two groups was statistically significant (χ2=4.47, P=0.034). Multivariate COX regression analysis: High nutritional risk was a risk factor for hospitalization of hospitalized infants with lower respiratory tract infection (RR=1.57, P=0.024). \u0000 \u0000 \u0000Conclusion \u0000There is a high incidence of high nutritional risk in infants with lower respiratory tract infection. Compared with children with low and moderate nutritional risk, the hospitalization time is longer, the hospitalization cost is increased, and the clinical cure rate is lower, which is the risk of clinical outcome. factor. Therefore, it is necessary to conduct nutrition risk screening for infants with lower respiratory tract infections, and provide a theoretical basis for clinical nutrition evaluation and nutritional intervention. \u0000 \u0000 \u0000Key words: \u0000Respiratory infections; Infants; Nutritional status and growth risk screening tools","PeriodicalId":9877,"journal":{"name":"Chinese Journal of Clinical Nutrition","volume":"27 1","pages":"233-237"},"PeriodicalIF":0.0,"publicationDate":"2019-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49024398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-30DOI: 10.3760/CMA.J.ISSN.1674-635X.2019.04.005
Ruoning Qu, Q. Yu, Zong-liang Yang
Objective To evaluate the effect of clinical pharmacists on parenteral nutrition support interventions, and to provide reference for clinical pharmacists to participate in the ERAS Nutrition Support Group work model. Methods A total of 490 patients hospitalized in department of hepatobiliary and pancreatic surgery from November 2016 to January 2017 were selected as control group. 521 patients hospitalized in department of hepatobiliary and pancreatic surgery from November 2018 to January 2019 were selected as intervention group. Nutritional risk, parenteral nutrition support indications, parenteral nutrition prescription energy and amino acid supply, prescription incompatibility and rationality, prescription osmotic concentration and phlebitis, parenteral nutrition and drugs in Y-tube compatibility of the above patients were analyzed to evaluate the effect of interventions by clinical pharmacists after participating in the nutritional support team. Results Patients with benign pancreatic diseases in the two groups had higher incidence of nutritional risk (78.2%, 75.6%), and patients with benign biliary diseases had lower incidence of nutritional risk (76.4%, 69.9%). Incidence of patients having parenteral nutrition support indications, namely NRS 2002≥3 points was higher in intervention group (83.6%) than in control group (56.6%); parenteral nutrition prescription energy and amino acid supply were higher in intervention group than in control group, patients in the intervention group had lower blood albumin dosage and no over-indication medication than patients in the control group; patients in both groups had no parenteral nutrition prescription safety issues such as glycolipid ratio (kJ∶kJ) 0.05). The compatibility of parenteral nutrition solution and drug in Y-tube was lower in the intervention group than in the control group. Conclusion The participation of clinical pharmacist in the ERAS nutrition treatment team, who will assist the doctor in formulating the nutritional treatment plan, monitor the patient's nutritional support and conduct regular indoor training, can effectively improve the reasonable application of parenteral nutrition support, standardize the use of therapeutic drugs, and guide patients and caregivers to use the preparations safely so that to ensure patients' safety in clinical interventions. Key words: Department of hepatobiliary and pancreatic surgery; Clinical pharmacist; Nutritional Risk; Parenteral nutrition support; Total nutrition admixture
{"title":"Effect of clinical pharmacists participating in parenteral nutrition support intervention in patients hospitalized in hepatobiliary and pancreatic surgery","authors":"Ruoning Qu, Q. Yu, Zong-liang Yang","doi":"10.3760/CMA.J.ISSN.1674-635X.2019.04.005","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-635X.2019.04.005","url":null,"abstract":"Objective \u0000To evaluate the effect of clinical pharmacists on parenteral nutrition support interventions, and to provide reference for clinical pharmacists to participate in the ERAS Nutrition Support Group work model. \u0000 \u0000 \u0000Methods \u0000A total of 490 patients hospitalized in department of hepatobiliary and pancreatic surgery from November 2016 to January 2017 were selected as control group. 521 patients hospitalized in department of hepatobiliary and pancreatic surgery from November 2018 to January 2019 were selected as intervention group. Nutritional risk, parenteral nutrition support indications, parenteral nutrition prescription energy and amino acid supply, prescription incompatibility and rationality, prescription osmotic concentration and phlebitis, parenteral nutrition and drugs in Y-tube compatibility of the above patients were analyzed to evaluate the effect of interventions by clinical pharmacists after participating in the nutritional support team. \u0000 \u0000 \u0000Results \u0000Patients with benign pancreatic diseases in the two groups had higher incidence of nutritional risk (78.2%, 75.6%), and patients with benign biliary diseases had lower incidence of nutritional risk (76.4%, 69.9%). Incidence of patients having parenteral nutrition support indications, namely NRS 2002≥3 points was higher in intervention group (83.6%) than in control group (56.6%); parenteral nutrition prescription energy and amino acid supply were higher in intervention group than in control group, patients in the intervention group had lower blood albumin dosage and no over-indication medication than patients in the control group; patients in both groups had no parenteral nutrition prescription safety issues such as glycolipid ratio (kJ∶kJ) 0.05). The compatibility of parenteral nutrition solution and drug in Y-tube was lower in the intervention group than in the control group. \u0000 \u0000 \u0000Conclusion \u0000The participation of clinical pharmacist in the ERAS nutrition treatment team, who will assist the doctor in formulating the nutritional treatment plan, monitor the patient's nutritional support and conduct regular indoor training, can effectively improve the reasonable application of parenteral nutrition support, standardize the use of therapeutic drugs, and guide patients and caregivers to use the preparations safely so that to ensure patients' safety in clinical interventions. \u0000 \u0000 \u0000Key words: \u0000Department of hepatobiliary and pancreatic surgery; Clinical pharmacist; Nutritional Risk; Parenteral nutrition support; Total nutrition admixture","PeriodicalId":9877,"journal":{"name":"Chinese Journal of Clinical Nutrition","volume":"27 1","pages":"227-232"},"PeriodicalIF":0.0,"publicationDate":"2019-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42841065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-06-30DOI: 10.3760/CMA.J.ISSN.1674-635X.2019.03.010
Yi Wang, P. Shan
Objective To investigate the effect of enteral nutrition and probiotics on inflammatory factors and immune function in aplastic anemia (AA) rats. Methods AA rats model were established by intraperitoneal injection of fluorouracil and lavage Maryland, and the successful AA rats model were randomly divided into model group, enteral nutrition group, probiotics group and combination group, 10 rats in each group. Another 10 Wistar rats were selected as blank group. Rats in the blank group and model group were given saline lavage (same volume 0.9% NaCl), rats in the enteral nutrition group were given Peptisorb nutrient solution [10 g/(kg·d)] by lavage, rats in the probiotics group were given live Clostridium butyricum [2 g/(kg·d)] by lavage, and rats in the combination group were given Peptisorb nutrient solution [10 g/(kg·d)] and live Clostridium butyricum [2 g/(kg·d)] by lavage for 4 weeks. The pathological structure of the bone marrow were observed by HE staining, the contents of white blood cells (WBC), red blood cell (RBC), platelet (PLT) and hemoglobin (Hb) in blood cell were detected by analyzer, the levels of serum tumor necrosis factor alpha (TNF-α), interleukin-2 (IL-2) and interleukin-11 (IL-11) were detected by ELISA method, and the contents of CD4+, CD8+ and NKT cells were detected by flow cytometry instrument. Results The contents of WBC, RBC, PLT and Hb in the model group were significantly lower than that in the blank group, the contents of WBC, RBC, PLT and Hb in enteral nutrition group, probiotics group and combination group were significantly higher than that in the model group, and the combination group was better than the enteral nutrition group and probiotics group (P 0.05). The level of TNF-α and IL-2 were significantly higher and the IL-11 level was significantly lower in the model group than in the blank group, the level of TNF-α and IL-2 were significantly lower and IL-11 level were significantly higher in the enteral nutrition group, probiotics group and combination group than in the model group, and the combination group was better than the enteral nutrition group and probiotics group (P 0.05). The contents of CD4+ and NKT cells were significantly lower and the CD8+ cells was significantly higher in the model group than in the blank group, the level of CD4+ and NKT cells were significantly higher and CD8+ cells were significantly lower in enteral nutrition group, probiotics group and combination group than in the model group, and the combination group was better than the enteral nutrition group and probiotics group (P 0.05). Conclusion Compared with normal consumption or oral glucose, the enteral nutrition combined with probiotics can reduce inflammatory response and improve bone marrow hematopoietic function and immune function in AA rats. Key words: Aplastic anemia; Enteral nutrition; Probiotics; Inflammation factors; Immune function
{"title":"Effect of enteral nutrition and probiotics on inflammatory factors and immune function in aplastic anemia rats","authors":"Yi Wang, P. Shan","doi":"10.3760/CMA.J.ISSN.1674-635X.2019.03.010","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-635X.2019.03.010","url":null,"abstract":"Objective \u0000To investigate the effect of enteral nutrition and probiotics on inflammatory factors and immune function in aplastic anemia (AA) rats. \u0000 \u0000 \u0000Methods \u0000AA rats model were established by intraperitoneal injection of fluorouracil and lavage Maryland, and the successful AA rats model were randomly divided into model group, enteral nutrition group, probiotics group and combination group, 10 rats in each group. Another 10 Wistar rats were selected as blank group. Rats in the blank group and model group were given saline lavage (same volume 0.9% NaCl), rats in the enteral nutrition group were given Peptisorb nutrient solution [10 g/(kg·d)] by lavage, rats in the probiotics group were given live Clostridium butyricum [2 g/(kg·d)] by lavage, and rats in the combination group were given Peptisorb nutrient solution [10 g/(kg·d)] and live Clostridium butyricum [2 g/(kg·d)] by lavage for 4 weeks. The pathological structure of the bone marrow were observed by HE staining, the contents of white blood cells (WBC), red blood cell (RBC), platelet (PLT) and hemoglobin (Hb) in blood cell were detected by analyzer, the levels of serum tumor necrosis factor alpha (TNF-α), interleukin-2 (IL-2) and interleukin-11 (IL-11) were detected by ELISA method, and the contents of CD4+, CD8+ and NKT cells were detected by flow cytometry instrument. \u0000 \u0000 \u0000Results \u0000The contents of WBC, RBC, PLT and Hb in the model group were significantly lower than that in the blank group, the contents of WBC, RBC, PLT and Hb in enteral nutrition group, probiotics group and combination group were significantly higher than that in the model group, and the combination group was better than the enteral nutrition group and probiotics group (P 0.05). The level of TNF-α and IL-2 were significantly higher and the IL-11 level was significantly lower in the model group than in the blank group, the level of TNF-α and IL-2 were significantly lower and IL-11 level were significantly higher in the enteral nutrition group, probiotics group and combination group than in the model group, and the combination group was better than the enteral nutrition group and probiotics group (P 0.05). The contents of CD4+ and NKT cells were significantly lower and the CD8+ cells was significantly higher in the model group than in the blank group, the level of CD4+ and NKT cells were significantly higher and CD8+ cells were significantly lower in enteral nutrition group, probiotics group and combination group than in the model group, and the combination group was better than the enteral nutrition group and probiotics group (P 0.05). \u0000 \u0000 \u0000Conclusion \u0000Compared with normal consumption or oral glucose, the enteral nutrition combined with probiotics can reduce inflammatory response and improve bone marrow hematopoietic function and immune function in AA rats. \u0000 \u0000 \u0000Key words: \u0000Aplastic anemia; Enteral nutrition; Probiotics; Inflammation factors; Immune function","PeriodicalId":9877,"journal":{"name":"Chinese Journal of Clinical Nutrition","volume":"59 9-10","pages":"179-183"},"PeriodicalIF":0.0,"publicationDate":"2019-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41303149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-06-30DOI: 10.3760/CMA.J.ISSN.1674-635X.2019.03.003
Jiapei Li, Weigang Zhao, Yong Fu, Ying-yue Dong, Juan Li
Objective To explore the relationship of MTNR1B DNA methylation with gestational diabetes and gestational glucose and lipid metabolism features. Methods 50 patients with gestational hyperglycemia, diagnosed by 100 g oral glucose tolerance test(OGTT) during mid-trimester were selected between 2009 and 2012. 50 pregnant women with normal glucose tolerance of matched age and body mass index were included in the control group. The blood samples during mid-trimester and the clinical parameters were collected. MTNR1B DNA methylation levels were measured. Results After adjusting age and body mass index, the CpG locus located at + 64 bp away from the translation initiation site of MTNR1B was related with gestational diabetes (OR=0.859, 95% CI: 0.772-0.955, P=0.005). DNA methylation level of several MTNR1B loci was also related with gestational glucose and lipid metabolism features. Conclusion MTNR1B DNA methylation is related with gestational diabetes and gestational glucose and lipid metabolism. Key words: MTNR1B DNA methylation; Gestational diabetes mellitus; Gestational glucose and lipid metabolism
{"title":"Relationship of MTNR1B DNA methylation with gestational diabetes and gestational glucose and lipid metabolism features","authors":"Jiapei Li, Weigang Zhao, Yong Fu, Ying-yue Dong, Juan Li","doi":"10.3760/CMA.J.ISSN.1674-635X.2019.03.003","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-635X.2019.03.003","url":null,"abstract":"Objective \u0000To explore the relationship of MTNR1B DNA methylation with gestational diabetes and gestational glucose and lipid metabolism features. \u0000 \u0000 \u0000Methods \u000050 patients with gestational hyperglycemia, diagnosed by 100 g oral glucose tolerance test(OGTT) during mid-trimester were selected between 2009 and 2012. 50 pregnant women with normal glucose tolerance of matched age and body mass index were included in the control group. The blood samples during mid-trimester and the clinical parameters were collected. MTNR1B DNA methylation levels were measured. \u0000 \u0000 \u0000Results \u0000After adjusting age and body mass index, the CpG locus located at + 64 bp away from the translation initiation site of MTNR1B was related with gestational diabetes (OR=0.859, 95% CI: 0.772-0.955, P=0.005). DNA methylation level of several MTNR1B loci was also related with gestational glucose and lipid metabolism features. \u0000 \u0000 \u0000Conclusion \u0000MTNR1B DNA methylation is related with gestational diabetes and gestational glucose and lipid metabolism. \u0000 \u0000 \u0000Key words: \u0000MTNR1B DNA methylation; Gestational diabetes mellitus; Gestational glucose and lipid metabolism","PeriodicalId":9877,"journal":{"name":"Chinese Journal of Clinical Nutrition","volume":"27 1","pages":"138-143"},"PeriodicalIF":0.0,"publicationDate":"2019-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46409460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-06-30DOI: 10.3760/CMA.J.ISSN.1674-635X.2019.03.007
Lin Geng
Objective To investigate the relevant factors of type 2 diabetes mellitus(T2DM) with cerebral infarction(CI). Methods A total of 323 patients with T2DM from February 2012 to March 2017 in Inner Mongolia medical university affiliated hospital were included in this study. 150 patients with T2DM and CI were considered as experiment group, 173 cases of T2DM without CI were considered as control group. The clinical data of two groups were analyzed. Results The history of diabetes, smoking and hypertension were longer in experiment group than in control group (P<0.05). The patients in experiment group had higher fasting blood glucose(FBG), glycosylated hemoglobin(HbA1c), total triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), non-HDL-C, homocysteine(Hcy), fibrinogen(FIB), retinol binding protein 4(RBP4) and lower HDL-C, apolipoprotein A1(ApoA1) than the patients in control group(P<0.05). Multiple-factor logistic regression analysis showed that long-term smoking, long history of hypertension, high TG, high LDL-C, high non-HDL-C, high Hcy, high RBP4, low HDL-C and low ApoA1 were risk factors for CI in patients with T2DM (P<0.05). After adjusting common variables (diabetes history, hypertension history, smoking history, HbA1c, TG, TC), multiple-factor logistic regression analysis showed that LDL-C, non-HDL-C, Hcy, RBP4 were risk factors for CI in T2DM (P<0.05). HDL-C and ApoA1 were protective factors for CI in T2DM (P<0.05). Conclusion The risk factors for CI in patients with T2DM include long-term smoking, long hypertension history, high HbA1c, high TG, high LDL-C, high non-HDL-C, high Hcy, high RBP4, low HDL-C and low ApoA1. Patients should be advised to quit smoking, control blood glucose and blood pressure, and regulate blood lipid levels. Key words: Type 2 diabetes mellitus; Cerebral infarction; Relevant factors
{"title":"Relevant factors of type 2 diabetic patients with cerebral infarction","authors":"Lin Geng","doi":"10.3760/CMA.J.ISSN.1674-635X.2019.03.007","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-635X.2019.03.007","url":null,"abstract":"Objective \u0000To investigate the relevant factors of type 2 diabetes mellitus(T2DM) with cerebral infarction(CI). \u0000 \u0000 \u0000Methods \u0000A total of 323 patients with T2DM from February 2012 to March 2017 in Inner Mongolia medical university affiliated hospital were included in this study. 150 patients with T2DM and CI were considered as experiment group, 173 cases of T2DM without CI were considered as control group. The clinical data of two groups were analyzed. \u0000 \u0000 \u0000Results \u0000The history of diabetes, smoking and hypertension were longer in experiment group than in control group (P<0.05). The patients in experiment group had higher fasting blood glucose(FBG), glycosylated hemoglobin(HbA1c), total triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), non-HDL-C, homocysteine(Hcy), fibrinogen(FIB), retinol binding protein 4(RBP4) and lower HDL-C, apolipoprotein A1(ApoA1) than the patients in control group(P<0.05). Multiple-factor logistic regression analysis showed that long-term smoking, long history of hypertension, high TG, high LDL-C, high non-HDL-C, high Hcy, high RBP4, low HDL-C and low ApoA1 were risk factors for CI in patients with T2DM (P<0.05). After adjusting common variables (diabetes history, hypertension history, smoking history, HbA1c, TG, TC), multiple-factor logistic regression analysis showed that LDL-C, non-HDL-C, Hcy, RBP4 were risk factors for CI in T2DM (P<0.05). HDL-C and ApoA1 were protective factors for CI in T2DM (P<0.05). \u0000 \u0000 \u0000Conclusion \u0000The risk factors for CI in patients with T2DM include long-term smoking, long hypertension history, high HbA1c, high TG, high LDL-C, high non-HDL-C, high Hcy, high RBP4, low HDL-C and low ApoA1. Patients should be advised to quit smoking, control blood glucose and blood pressure, and regulate blood lipid levels. \u0000 \u0000 \u0000Key words: \u0000Type 2 diabetes mellitus; Cerebral infarction; Relevant factors","PeriodicalId":9877,"journal":{"name":"Chinese Journal of Clinical Nutrition","volume":"27 1","pages":"161-166"},"PeriodicalIF":0.0,"publicationDate":"2019-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43163516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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