Pub Date : 2020-01-20DOI: 10.3760/CMA.J.CN371469-20190624-00401
Ting-Mei Wang, Bo Xiang, Guohua Wang, X. Liang, Kezhi Liu
Objective To investigate the improvement and possible mechanism of dl-3-n-butylphthalide (NBP) on the emotional memory of chronic alcoholism model mice. Methods Twenty-four adult male C57/BL6 mice were randomly divided into control group (CON, n=8), model group (AT, n=8), treatment group (AT+ NBP, n=8). Mice in AT group and AT+ NBP group were administrated with alcohol to establish chronic alcoholism model. In the AT+ NBP group, the mice was administrated with NBP (40 mg/kg) by gavage once a day for 14 days during the alcohol modeling period. Ang the mice in AT group and CON group was given the same dose of corn oil by gavage.Open field test was used to evaluate anxiety-like behavior, tail suspension test to evaluate depression-like behavior, Morris water maze and new object recognition to evaluate memory ability, and TUNEL staining to evaluate the number of neuron apoptosis. The primary cultured neurons were interfered by alcohol and NBP at the cell level, and the calcium concentration in the neurons was detected by fluorescence calcium imaging. Descriptive analysis, t-test and one-way ANOVA were processed by SPSS 17.0. Results The results of open field test showed that the exploration time of AT+ NBP group was longer than that of AT group ((50.68±7.82)s, (38.50±13.93)s; t=-2.16, P<0.05)). In the spatial memory test, the target quadrant exploration time of AT+ NBP group was longer than that of AT group ((28.02±7.13)s, (20.98±5.58)s; t=-2.20, P<0.05). In short memory test, the cognitive coefficient RI (0.83±0.08) of AT+ NBP group was higher than that of AT group (0.68±0.10) (t=-3.13, P<0.05). Compared with CON group, the number of neuron apoptosis in prefrontal cortex in AT group increased ((17.33±2.51), (115.67±6.50); t=-24.41, P<0.001), and that in AT+ NBP group decreased compared with AT group((45.00±5.57)) (t=14.29, P<0.001). The number of apoptosis neurons in the dentate gyrus of the hippocampus in AT group (13.75±4.79) was also less than that in the AT+ NBP group (5.75±3.30) (t=2.75, P<0.05). Calcium concentration in nerve cells was detected that the three concentrations of alcohol (100 mmol/L, 200 mmol/L and 300 mmol/L) led to a significant increase in the RFU within the nerve cells (△F/F) ((1.43±0.32), (2.31±1.39), (1.21±0.73); t=-7.67, -2.85, -2.86, all P<0.05). In comparison, the changes of RFU in the three groups treated with NBP treatment were relatively stable ((0.04±0.01), (-0.03±0.01), (-0.04±0.02); t=7.96, 2.96, 2.92, all P< 0.05). Conclusion The 3-n-Butylphthalide can improve the learning and memory ability of chronic alcoholism model mice, which may be related with the inhibition of neuron apoptosis and the influence of intracellular calcium homeostasis. Key words: DL-3-n-Butylphthalide; Alcoholism; Anxiety; Memory; Neuronal apoptosis; Calcium homeostasis
{"title":"Effect and mechanism of DL-3-n-butylphthalide on emotional memory in mice with chronic alcoholism","authors":"Ting-Mei Wang, Bo Xiang, Guohua Wang, X. Liang, Kezhi Liu","doi":"10.3760/CMA.J.CN371469-20190624-00401","DOIUrl":"https://doi.org/10.3760/CMA.J.CN371469-20190624-00401","url":null,"abstract":"Objective \u0000To investigate the improvement and possible mechanism of dl-3-n-butylphthalide (NBP) on the emotional memory of chronic alcoholism model mice. \u0000 \u0000 \u0000Methods \u0000Twenty-four adult male C57/BL6 mice were randomly divided into control group (CON, n=8), model group (AT, n=8), treatment group (AT+ NBP, n=8). Mice in AT group and AT+ NBP group were administrated with alcohol to establish chronic alcoholism model. In the AT+ NBP group, the mice was administrated with NBP (40 mg/kg) by gavage once a day for 14 days during the alcohol modeling period. Ang the mice in AT group and CON group was given the same dose of corn oil by gavage.Open field test was used to evaluate anxiety-like behavior, tail suspension test to evaluate depression-like behavior, Morris water maze and new object recognition to evaluate memory ability, and TUNEL staining to evaluate the number of neuron apoptosis. The primary cultured neurons were interfered by alcohol and NBP at the cell level, and the calcium concentration in the neurons was detected by fluorescence calcium imaging. Descriptive analysis, t-test and one-way ANOVA were processed by SPSS 17.0. \u0000 \u0000 \u0000Results \u0000The results of open field test showed that the exploration time of AT+ NBP group was longer than that of AT group ((50.68±7.82)s, (38.50±13.93)s; t=-2.16, P<0.05)). In the spatial memory test, the target quadrant exploration time of AT+ NBP group was longer than that of AT group ((28.02±7.13)s, (20.98±5.58)s; t=-2.20, P<0.05). In short memory test, the cognitive coefficient RI (0.83±0.08) of AT+ NBP group was higher than that of AT group (0.68±0.10) (t=-3.13, P<0.05). Compared with CON group, the number of neuron apoptosis in prefrontal cortex in AT group increased ((17.33±2.51), (115.67±6.50); t=-24.41, P<0.001), and that in AT+ NBP group decreased compared with AT group((45.00±5.57)) (t=14.29, P<0.001). The number of apoptosis neurons in the dentate gyrus of the hippocampus in AT group (13.75±4.79) was also less than that in the AT+ NBP group (5.75±3.30) (t=2.75, P<0.05). Calcium concentration in nerve cells was detected that the three concentrations of alcohol (100 mmol/L, 200 mmol/L and 300 mmol/L) led to a significant increase in the RFU within the nerve cells (△F/F) ((1.43±0.32), (2.31±1.39), (1.21±0.73); t=-7.67, -2.85, -2.86, all P<0.05). In comparison, the changes of RFU in the three groups treated with NBP treatment were relatively stable ((0.04±0.01), (-0.03±0.01), (-0.04±0.02); t=7.96, 2.96, 2.92, all P< 0.05). \u0000 \u0000 \u0000Conclusion \u0000The 3-n-Butylphthalide can improve the learning and memory ability of chronic alcoholism model mice, which may be related with the inhibition of neuron apoptosis and the influence of intracellular calcium homeostasis. \u0000 \u0000 \u0000Key words: \u0000DL-3-n-Butylphthalide; Alcoholism; Anxiety; Memory; Neuronal apoptosis; Calcium homeostasis","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"29 1","pages":"14-20"},"PeriodicalIF":0.0,"publicationDate":"2020-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49496302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-20DOI: 10.3760/CMA.J.CN371468-20190424-00283
Yang Huai-jie, Yang Hong, Yan Li, Xiang Wenying, Wang Tao
Objective To survey the influencing factors for depression based on path model analysis in late pregnant women, and to explore the interrelationships for depression. Methods This cross-sectional study was conducted from January 2018 to March 2019.Antenatal women who came for a routine check-up at the antenatal clinic were invited to participate in the study.Collecting general information of pregnant women(including biological, psychological, social and other factors). The Hospital Anxiety and Depression Scale (HADS) was used to evaluate the incidence of depression during pregnancy.The differences between depression group and non-depression group were compared by SPSS 24.0, and the path analysis model was conducted by AMOS 21.0 to explore the influencing factors and interrelations of depression during pregnancy. Results A total of 1 059 pregnant women completed questionnaire.The incidence of depression depression in third trimester women was 11.1%(118/1 059). The path model fitting well with the sample data(GFI=0.912, AGFI=0.901, RFI=0.920, CFI=0.931, RMSEA=0.033). Anxiety, psychological preparation for the current pregnancy, and level of education had both direct and indirect effects on depression in third trimester women(the total effects of the three factors were 0.381, -0.140 and -0.156, respectively). Sleep quality and family member with whom the pregnant women living during pregnancy had only direct effects (the effects were 0.136 and 0.107, respectively). Residence, monthly income of family and social support had only an indirect influence on depression(the effects were 0.175, 0.103, and 0.102, respectively). Conclusion Path model analysis suggests that the residence, monthly income of family, family member with whom the pregnant women living during pregnancy and educational level are not easy to change. It is suggested the incidence of depression is reduced by intervening the pregnancy anxiety, social support, sleep quality and the psychological preparation for pregnancy. Key words: Late pregnancy; Depression; Influencing factors; Path model analysis
{"title":"Path model analysis of influencing factors on depression in late pregnant women","authors":"Yang Huai-jie, Yang Hong, Yan Li, Xiang Wenying, Wang Tao","doi":"10.3760/CMA.J.CN371468-20190424-00283","DOIUrl":"https://doi.org/10.3760/CMA.J.CN371468-20190424-00283","url":null,"abstract":"Objective \u0000To survey the influencing factors for depression based on path model analysis in late pregnant women, and to explore the interrelationships for depression. \u0000 \u0000 \u0000Methods \u0000This cross-sectional study was conducted from January 2018 to March 2019.Antenatal women who came for a routine check-up at the antenatal clinic were invited to participate in the study.Collecting general information of pregnant women(including biological, psychological, social and other factors). The Hospital Anxiety and Depression Scale (HADS) was used to evaluate the incidence of depression during pregnancy.The differences between depression group and non-depression group were compared by SPSS 24.0, and the path analysis model was conducted by AMOS 21.0 to explore the influencing factors and interrelations of depression during pregnancy. \u0000 \u0000 \u0000Results \u0000A total of 1 059 pregnant women completed questionnaire.The incidence of depression depression in third trimester women was 11.1%(118/1 059). The path model fitting well with the sample data(GFI=0.912, AGFI=0.901, RFI=0.920, CFI=0.931, RMSEA=0.033). Anxiety, psychological preparation for the current pregnancy, and level of education had both direct and indirect effects on depression in third trimester women(the total effects of the three factors were 0.381, -0.140 and -0.156, respectively). Sleep quality and family member with whom the pregnant women living during pregnancy had only direct effects (the effects were 0.136 and 0.107, respectively). Residence, monthly income of family and social support had only an indirect influence on depression(the effects were 0.175, 0.103, and 0.102, respectively). \u0000 \u0000 \u0000Conclusion \u0000Path model analysis suggests that the residence, monthly income of family, family member with whom the pregnant women living during pregnancy and educational level are not easy to change. It is suggested the incidence of depression is reduced by intervening the pregnancy anxiety, social support, sleep quality and the psychological preparation for pregnancy. \u0000 \u0000 \u0000Key words: \u0000Late pregnancy; Depression; Influencing factors; Path model analysis","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"29 1","pages":"38-43"},"PeriodicalIF":0.0,"publicationDate":"2020-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43633161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-20DOI: 10.3760/CMA.J.CN371468-20190819-00562
Fan Wang, Yu Li, Shengling Li, Yanhong Liu, Cai-jiang Sun, Yongfang Hu
Objective To investigate the application effect of kangaroo mother care on anxiety and parenting stress in premature mothers during hospitalization. Methods From January to December 2018, 230 premature mothers were admitted to the neonatal intensive care unit of Ningxia Medical University General Hospital.They were randomly divided into the intervention group(n=114) and the control group(n=116). The premature infants in control group only implemented routine developmental support care.The premature infants in the intervention group was on the basis of routine developmental support care, 2 hours per day of kangaroo mother care was performed from the 2nd day incharge to discharge.Parental Stress Scale: Neonatal Intensive Care Unit and Parenting Stress Index-Short Form was performed using the 2nd day and the 14th day of hospitalization, and the two groups of premature mothers were evaluated for anxiety and parenting stress. Results There were no significant differences in the scores of PSS: NICU((3.65±0.91) vs (3.63±0.91)) and PSI-SF((90.32±8.95) vs (90.12±7.17))(both P>0.05) between the two groups on the 2nd day of hospitalization (before intervention). On the 14th day of hospitalization (after intervention), the total scores ((2.57±0.80) vs (3.47±0.93))and each dimension scores of PSS: NICU in the intervention group were lower than those in the control group (first part (2.41±0.78) vs (3.81±0.73), second part (2.61±0.71) vs (3.14±0.83), third part (2.75±0.86) vs (3.57±1.06), fourth part(2.49±0.80) vs (3.35±0.94))(P<0.01). In addition, the total score of PSI-SF((79.09±8.02) vs (89.46±8.74)), parenting Distress((32.32±9.48) vs (37.15±9.67)), Parent-Child Dysfunctional Interaction((24.26±5.07) vs (27.34±5.26)), and Difficult Child scores((22.51±4.88) vs (24.97±5.05)) in the intervention group were lower than those in the control group(P<0.01). Conclusion Kangaroo mother care can reduce the anxiety of premature mothers during hospitalization and help relieve the parenting stress of premature mothers. Key words: Kangaroo mother care; Premature infant; Anxiety; Parenting stress
{"title":"Effects of kangaroo mother care on anxiety and parenting stress in premature mothers","authors":"Fan Wang, Yu Li, Shengling Li, Yanhong Liu, Cai-jiang Sun, Yongfang Hu","doi":"10.3760/CMA.J.CN371468-20190819-00562","DOIUrl":"https://doi.org/10.3760/CMA.J.CN371468-20190819-00562","url":null,"abstract":"Objective \u0000To investigate the application effect of kangaroo mother care on anxiety and parenting stress in premature mothers during hospitalization. \u0000 \u0000 \u0000Methods \u0000From January to December 2018, 230 premature mothers were admitted to the neonatal intensive care unit of Ningxia Medical University General Hospital.They were randomly divided into the intervention group(n=114) and the control group(n=116). The premature infants in control group only implemented routine developmental support care.The premature infants in the intervention group was on the basis of routine developmental support care, 2 hours per day of kangaroo mother care was performed from the 2nd day incharge to discharge.Parental Stress Scale: Neonatal Intensive Care Unit and Parenting Stress Index-Short Form was performed using the 2nd day and the 14th day of hospitalization, and the two groups of premature mothers were evaluated for anxiety and parenting stress. \u0000 \u0000 \u0000Results \u0000There were no significant differences in the scores of PSS: NICU((3.65±0.91) vs (3.63±0.91)) and PSI-SF((90.32±8.95) vs (90.12±7.17))(both P>0.05) between the two groups on the 2nd day of hospitalization (before intervention). On the 14th day of hospitalization (after intervention), the total scores ((2.57±0.80) vs (3.47±0.93))and each dimension scores of PSS: NICU in the intervention group were lower than those in the control group (first part (2.41±0.78) vs (3.81±0.73), second part (2.61±0.71) vs (3.14±0.83), third part (2.75±0.86) vs (3.57±1.06), fourth part(2.49±0.80) vs (3.35±0.94))(P<0.01). In addition, the total score of PSI-SF((79.09±8.02) vs (89.46±8.74)), parenting Distress((32.32±9.48) vs (37.15±9.67)), Parent-Child Dysfunctional Interaction((24.26±5.07) vs (27.34±5.26)), and Difficult Child scores((22.51±4.88) vs (24.97±5.05)) in the intervention group were lower than those in the control group(P<0.01). \u0000 \u0000 \u0000Conclusion \u0000Kangaroo mother care can reduce the anxiety of premature mothers during hospitalization and help relieve the parenting stress of premature mothers. \u0000 \u0000 \u0000Key words: \u0000Kangaroo mother care; Premature infant; Anxiety; Parenting stress","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"29 1","pages":"74-78"},"PeriodicalIF":0.0,"publicationDate":"2020-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45506368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective To explore the mechanism of the influence of just world belief on depression in college students, and to explore the multiple mediating effects of hope and forgiveness. Methods Totally 290 college students were assessed by belief in a just world scale(BJWS), adult dispositional hope scale(ADHS), Hearland forgiveness scale(HFS) and self-rating depression scale(SDS). Results The scores of the belief in a just world, hope, forgiveness and depression were 53.90±7.83, 33.67±3.87, 109.75±12.52 and 16.84±8.41, respectively.The belief in a just world was positively correlated with hope(r=0.41, P<0.01) and forgiveness(r=0.40, P<0.01), and negatively correlated with depression(r=-0.38, P<0.01). Hope was positively correlated with forgiveness(r=0.43, P<0.01), and negatively correlated with depression(r=-0.53, P<0.01). Forgiveness had a significantly negative correlation with depression(r=-0.57, P<0.01). Structural equation model showed that the direct effect of the belief in a just world on depression was not statistically significant.The belief in a just world can influence depression by multiple mediators of hope(the effective amount=0.26), hope→forgiveness(the effective amount=0.20), and the model fitted well(χ2/df=1.63, RMSEA=0.04, GFI=0.96, NFI=0.98, CFI=0.99). Conclusion The belief in a just world can influence depression by multiple mediators role of hope, hope→forgiveness. Key words: Just world belief; Hope; Forgiveness; Depression; Multiple mediation
{"title":"Relationship between just world belief and depression of college students: the multiple mediators of hope and forgiveness","authors":"Zhu Xiao, Haixia Wang, Yu Guo, Bing Lin, Huaibin Jiang","doi":"10.3760/CMA.J.CN371468-20190520-00331","DOIUrl":"https://doi.org/10.3760/CMA.J.CN371468-20190520-00331","url":null,"abstract":"Objective \u0000To explore the mechanism of the influence of just world belief on depression in college students, and to explore the multiple mediating effects of hope and forgiveness. \u0000 \u0000 \u0000Methods \u0000Totally 290 college students were assessed by belief in a just world scale(BJWS), adult dispositional hope scale(ADHS), Hearland forgiveness scale(HFS) and self-rating depression scale(SDS). \u0000 \u0000 \u0000Results \u0000The scores of the belief in a just world, hope, forgiveness and depression were 53.90±7.83, 33.67±3.87, 109.75±12.52 and 16.84±8.41, respectively.The belief in a just world was positively correlated with hope(r=0.41, P<0.01) and forgiveness(r=0.40, P<0.01), and negatively correlated with depression(r=-0.38, P<0.01). Hope was positively correlated with forgiveness(r=0.43, P<0.01), and negatively correlated with depression(r=-0.53, P<0.01). Forgiveness had a significantly negative correlation with depression(r=-0.57, P<0.01). Structural equation model showed that the direct effect of the belief in a just world on depression was not statistically significant.The belief in a just world can influence depression by multiple mediators of hope(the effective amount=0.26), hope→forgiveness(the effective amount=0.20), and the model fitted well(χ2/df=1.63, RMSEA=0.04, GFI=0.96, NFI=0.98, CFI=0.99). \u0000 \u0000 \u0000Conclusion \u0000The belief in a just world can influence depression by multiple mediators role of hope, hope→forgiveness. \u0000 \u0000 \u0000Key words: \u0000Just world belief; Hope; Forgiveness; Depression; Multiple mediation","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"29 1","pages":"70-73"},"PeriodicalIF":0.0,"publicationDate":"2020-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48306499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-20DOI: 10.3760/CMA.J.CN371468-20190606-00372
Na Liu, Y. Sang, Jiao Chen, Xiaoming Liu
Objective To explore the correlation between executive dysfunction and serum glial-derived neurotrophic factor (GDNF) levels in children with attention deficit hyperactivity disorder (ADHD). Methods 32 drug-free ADHD patients and 34 normal children matched in gender, age and IQ were included.The executive function was assessed using Digital Span Back Test (DSB-T), Trail Making Test (TMT), Semantic Fluency Test (SFT) and Stroop Color Word Test (SCW-T), and peripheral GDNF levels were measured by the enzyme linked immunosorbent assay (ELISA). The executive functional test scores and serum GDNF levels were compared between groups, and then the correlation between executive dysfunction and GDNF was analyzed by Spearman or pearson correlation analysis. Results (1) In the ADHD group, the DSB-T and SFT scores were lower than those in the normal control group(DSB-T4: (2) vs 5(1); SFT(13.66±2.34) vs (15.21±2.13)(Z=3.16, t=2.82, both P<0.05) and the TMT-A and TMT-B time-consuming were higher than those in the normal control group(TMT-A(61.12±19.03)s vs (48.76±21.06)s; TMT-B(158.66±63.78)s vs (123.62±45.24)s, t=2.50, 2.59, both P<0.05). The Word color consumption, word interference and word color errors of SCW-T in ADHD group were higher than those in the normal control group(Word color consumption(56.41±21.65)s vs (45.97±13.42)s; word interference 27(25)s vs 20(15)s; word color errors 4(3) vs 2(1)), and the differences were statistically significant(t=2.37, Z=2.31, 2.11, all P<0.05). (2) Serum levels of GDNF in the ADHD group were lower than that in the normal control group((481.59±68.74)pg/ml vs (552.47±110.13)pg/ml) , and the difference was statistically significant (t=3.11, P<0.05). (3) In the ADHD group, serum GDNF levels were negatively correlated with TMT-A, TMT-B and SCW-T word interference performance (r=-0.512, r=-0.578, r=-0.432, all P<0.05), and positively correlated with DSB-T performance(r=0.381, P<0.05). Conclusion Executive function is extensively damaged in ADHD patients, and GDNF may be involved in the pathophysiology of executive impairment. Key words: Attention deficit hyperactivity disorder; Glial-derived neurotrophic factor; Executive function; Children
目的探讨注意力缺陷多动障碍（ADHD）患儿执行功能障碍与血清胶质源性神经营养因子（GDNF）水平的相关性。方法选择32例无药物ADHD患者和34例性别、年龄、智商匹配的正常儿童。使用数字跨度背向测试（DSB-T）、线索制作测试（TMT）、语义流利性测试（SFT）和Stroop颜色词测试（SCW-T）评估执行功能，并通过酶联免疫吸附试验（ELISA）测量外周GDNF水平。比较各组执行功能测试得分和血清GDNF水平，然后通过Spearman或pearson相关分析分析执行功能障碍与GDNF之间的相关性。结果（1）ADHD组的DSB-T和SFT评分均低于正常对照组（DSB-T4:（2）vs 5（1）；SFT（13.66±2.34）vs（15.21±2.13）（Z=3.16，t=2.82，均P<0.05），TMT-A和TMT-B耗时均高于正常对照组（TMT-A（61.12±19.03）s vs（48.76±21.06）s；TMT-B（158.66±63.78）s vs（123.62±45.24）s，t=2.50，2.59，二者均P<0.05）。ADHD组SCW-t的词色消耗、词干扰和词色误差均高于正常对照组（词色消耗（56.41±21.65）svs（45.97±13.42）s；单词干扰27（25）s vs 20（15）s；单词颜色错误4（3）vs 2（1），差异有统计学意义（t=2.37，Z=2.31，2.11，均P<0.05）。（2）ADHD组血清GDNF水平低于正常对照组（（481.59±68.74）pg/ml vs（552.47±110.13）pg/ml），差异具有统计学意义（t=3.11，P<0.05），血清GDNF水平与TMT-A、TMT-B和SCW-T单词干扰表现呈负相关（r=-0.512，r=-0.578，r=-0.432，均P<0.05），与DSB-T表现呈正相关（r=0.381，P<0.05）。关键词：注意力缺陷多动障碍；胶质源性神经营养因子；执行职能；儿童
{"title":"Correlation analysis between executive dysfunction and serum glial-derived neurotrophic factor level in children with attention deficit/hyperactivity disorder","authors":"Na Liu, Y. Sang, Jiao Chen, Xiaoming Liu","doi":"10.3760/CMA.J.CN371468-20190606-00372","DOIUrl":"https://doi.org/10.3760/CMA.J.CN371468-20190606-00372","url":null,"abstract":"Objective \u0000To explore the correlation between executive dysfunction and serum glial-derived neurotrophic factor (GDNF) levels in children with attention deficit hyperactivity disorder (ADHD). \u0000 \u0000 \u0000Methods \u000032 drug-free ADHD patients and 34 normal children matched in gender, age and IQ were included.The executive function was assessed using Digital Span Back Test (DSB-T), Trail Making Test (TMT), Semantic Fluency Test (SFT) and Stroop Color Word Test (SCW-T), and peripheral GDNF levels were measured by the enzyme linked immunosorbent assay (ELISA). The executive functional test scores and serum GDNF levels were compared between groups, and then the correlation between executive dysfunction and GDNF was analyzed by Spearman or pearson correlation analysis. \u0000 \u0000 \u0000Results \u0000(1) In the ADHD group, the DSB-T and SFT scores were lower than those in the normal control group(DSB-T4: (2) vs 5(1); SFT(13.66±2.34) vs (15.21±2.13)(Z=3.16, t=2.82, both P<0.05) and the TMT-A and TMT-B time-consuming were higher than those in the normal control group(TMT-A(61.12±19.03)s vs (48.76±21.06)s; TMT-B(158.66±63.78)s vs (123.62±45.24)s, t=2.50, 2.59, both P<0.05). The Word color consumption, word interference and word color errors of SCW-T in ADHD group were higher than those in the normal control group(Word color consumption(56.41±21.65)s vs (45.97±13.42)s; word interference 27(25)s vs 20(15)s; word color errors 4(3) vs 2(1)), and the differences were statistically significant(t=2.37, Z=2.31, 2.11, all P<0.05). (2) Serum levels of GDNF in the ADHD group were lower than that in the normal control group((481.59±68.74)pg/ml vs (552.47±110.13)pg/ml) , and the difference was statistically significant (t=3.11, P<0.05). (3) In the ADHD group, serum GDNF levels were negatively correlated with TMT-A, TMT-B and SCW-T word interference performance (r=-0.512, r=-0.578, r=-0.432, all P<0.05), and positively correlated with DSB-T performance(r=0.381, P<0.05). \u0000 \u0000 \u0000Conclusion \u0000Executive function is extensively damaged in ADHD patients, and GDNF may be involved in the pathophysiology of executive impairment. \u0000 \u0000 \u0000Key words: \u0000Attention deficit hyperactivity disorder; Glial-derived neurotrophic factor; Executive function; Children","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"29 1","pages":"56-60"},"PeriodicalIF":0.0,"publicationDate":"2020-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45557165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-20DOI: 10.3760/CMA.J.CN371468-20190515-00317
Yidan Ming, Shuzhan Gao, Jiayin Wang, J. Zhai, Xijia Xu
Schizophrenia is a kind of neurodevelopmental brain disease with genetic background.Cognitive impairment has always been concerned as the core symptom of schizophrenia, and genetic factors play an important role in the cognitive impairment process of schizophrenia.This paper intends to explore the relationship between various neurotransmitter systems and neurodevelopmental related genes and cognitive impairment in schizophrenia. With " schizophrenia" " cognitive" and " genetic" " dopamine" " glutamate" " serotonin" " norepinephrine" " acetylcholine" " neurodevelopmental" " genome-wide association studies" as key words, the author searched the English and Chinese literatures published from January 2001 to October 2019 in several databases, such as Pubmed, ScienceDirect, CNKI academic journal database, Wanfang academic journal database, and selected the literature that was in line with the review topic after a large number of readings.Meanwhile, the author applied the literature tracing method to search the references of the literature that had been reviewed. Finally, 29 related literatures were included, and it was found that cognitive impairment in schizophrenia is related to multiple neurotransmitter system genes and neurodevelopmental genes, and these genes have different mechanisms of action in the process of cognitive impairment. The occurrence and development of cognitive impairment in schizophrenia involve multiple gene effects. The genetic study of neurotransmitter system and neurodevelopmental level is helpful to explore the pathological mechanism of cognitive impairment in schizophrenia.Future research should focus on how the pathogenesis/candidate genes of schizophrenia affect the neurotransmitter system and neurodevelopmental circuits, and further elucidate the mechanism of genetic factors in the development of cognitive impairment in schizophrenia. Key words: Schizophrenia; Cognitive dysfunction; Genetics
{"title":"Advances in the genetics of cognitive impairment in schizophrenia","authors":"Yidan Ming, Shuzhan Gao, Jiayin Wang, J. Zhai, Xijia Xu","doi":"10.3760/CMA.J.CN371468-20190515-00317","DOIUrl":"https://doi.org/10.3760/CMA.J.CN371468-20190515-00317","url":null,"abstract":"Schizophrenia is a kind of neurodevelopmental brain disease with genetic background.Cognitive impairment has always been concerned as the core symptom of schizophrenia, and genetic factors play an important role in the cognitive impairment process of schizophrenia.This paper intends to explore the relationship between various neurotransmitter systems and neurodevelopmental related genes and cognitive impairment in schizophrenia. With \" schizophrenia\" \" cognitive\" and \" genetic\" \" dopamine\" \" glutamate\" \" serotonin\" \" norepinephrine\" \" acetylcholine\" \" neurodevelopmental\" \" genome-wide association studies\" as key words, the author searched the English and Chinese literatures published from January 2001 to October 2019 in several databases, such as Pubmed, ScienceDirect, CNKI academic journal database, Wanfang academic journal database, and selected the literature that was in line with the review topic after a large number of readings.Meanwhile, the author applied the literature tracing method to search the references of the literature that had been reviewed. Finally, 29 related literatures were included, and it was found that cognitive impairment in schizophrenia is related to multiple neurotransmitter system genes and neurodevelopmental genes, and these genes have different mechanisms of action in the process of cognitive impairment. The occurrence and development of cognitive impairment in schizophrenia involve multiple gene effects. The genetic study of neurotransmitter system and neurodevelopmental level is helpful to explore the pathological mechanism of cognitive impairment in schizophrenia.Future research should focus on how the pathogenesis/candidate genes of schizophrenia affect the neurotransmitter system and neurodevelopmental circuits, and further elucidate the mechanism of genetic factors in the development of cognitive impairment in schizophrenia. \u0000 \u0000Key words: \u0000Schizophrenia; Cognitive dysfunction; Genetics","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"29 1","pages":"89-94"},"PeriodicalIF":0.0,"publicationDate":"2020-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45912215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-20DOI: 10.3760/CMA.J.CN371468-20190825-00576
Chong Zhang, Jieping Pan, Lin Ye, Jing Li
Objective To investigate the effects of maternal fluoxetine exposure on hypothalamic pituitary adrenal(HPA) axis and learning and memory function in female offspring rats. Methods Pregnant rats were divided into treatment group and control group by a table of random numbers, which were given fluoxetine (10 mg/kg per day) or the same amount of normal saline at 11-20 days of gestation, respectively.Ten female offspring from each group were selected randomly for open field, electrical maze and object recognition tests at 12 weeks after birth, and the concentrations of serum adrenocorticotropic hormone (ACTH) and corticosterone (CORT) were determined.Then they were given an unpredictable chronic stress (UCS) for 21 days, and the previous experiments were repeated.Finally, rats were sacrificed and the hypothalamus tissues were taken to measure the mRNA expression of corticotropin releasing hormone (CRH) and arginine vasopressin (AVP). SPSS 19.0 was used for data describing and t-test. Results Before UCS, there were no significant differences between the two groups among all the indexes(all P>0.05). After UCS, the horizontal movement and vertical movement of the rats in the two groups were significantly reduced compared with that before treatment, and the horizontal movement of the rats in the treatment group ((37.2±7.2) vs (50.8±8.5), t=4.73, P<0.01) and vertical movement ((10.6±2.0) vs (15.2±5.1), t=2.93, P<0.05) were lower than those in the control group.The correct reaction times decreased and the total reaction time increased in the two groups.While the correct response times of the treatment group were significantly lower than that of the control group (3.4±1.5) vs (4.5±0.9), t=2.36, P<0.05). The object recognition index of the rats in the treatment group decreased significantly compared with the control group ((0.11±0.04) vs (0.16±0.05), t=2.28, P<0.05). Before and after UCS, the change rate of ACTH ((61.13±26.08)% vs (29.83±12.73)%, t=3.67, P<0.01) and CORT ((105.71±18.39)% vs (74.15±39.24)%, t=2.34, P<0.05) in the treated group was significantly higher than that in the control group, and the mRNA expression of CRH in hypothalamus was significantly higher than that in the control group (t=4.15, P<0.01). Conclusion No significant damage is found to the HPA axis as well as learning and memory function of female offspring rats after exposure to fluoxetine in pregnancy, but the susceptibility of HPA axis as well as learning and memory function is increased under chronic stress. Key words: Fluoxetine; Learning and memory; Hypothalamic-pituitary-adrenal axis; Chronic stress
{"title":"Effects of maternal fluoxetine exposure on hypothalamic pituitary adrenal axis, as well as learning and memory function in female offspring rats after chronic stress","authors":"Chong Zhang, Jieping Pan, Lin Ye, Jing Li","doi":"10.3760/CMA.J.CN371468-20190825-00576","DOIUrl":"https://doi.org/10.3760/CMA.J.CN371468-20190825-00576","url":null,"abstract":"Objective \u0000To investigate the effects of maternal fluoxetine exposure on hypothalamic pituitary adrenal(HPA) axis and learning and memory function in female offspring rats. \u0000 \u0000 \u0000Methods \u0000Pregnant rats were divided into treatment group and control group by a table of random numbers, which were given fluoxetine (10 mg/kg per day) or the same amount of normal saline at 11-20 days of gestation, respectively.Ten female offspring from each group were selected randomly for open field, electrical maze and object recognition tests at 12 weeks after birth, and the concentrations of serum adrenocorticotropic hormone (ACTH) and corticosterone (CORT) were determined.Then they were given an unpredictable chronic stress (UCS) for 21 days, and the previous experiments were repeated.Finally, rats were sacrificed and the hypothalamus tissues were taken to measure the mRNA expression of corticotropin releasing hormone (CRH) and arginine vasopressin (AVP). SPSS 19.0 was used for data describing and t-test. \u0000 \u0000 \u0000Results \u0000Before UCS, there were no significant differences between the two groups among all the indexes(all P>0.05). After UCS, the horizontal movement and vertical movement of the rats in the two groups were significantly reduced compared with that before treatment, and the horizontal movement of the rats in the treatment group ((37.2±7.2) vs (50.8±8.5), t=4.73, P<0.01) and vertical movement ((10.6±2.0) vs (15.2±5.1), t=2.93, P<0.05) were lower than those in the control group.The correct reaction times decreased and the total reaction time increased in the two groups.While the correct response times of the treatment group were significantly lower than that of the control group (3.4±1.5) vs (4.5±0.9), t=2.36, P<0.05). The object recognition index of the rats in the treatment group decreased significantly compared with the control group ((0.11±0.04) vs (0.16±0.05), t=2.28, P<0.05). Before and after UCS, the change rate of ACTH ((61.13±26.08)% vs (29.83±12.73)%, t=3.67, P<0.01) and CORT ((105.71±18.39)% vs (74.15±39.24)%, t=2.34, P<0.05) in the treated group was significantly higher than that in the control group, and the mRNA expression of CRH in hypothalamus was significantly higher than that in the control group (t=4.15, P<0.01). \u0000 \u0000 \u0000Conclusion \u0000No significant damage is found to the HPA axis as well as learning and memory function of female offspring rats after exposure to fluoxetine in pregnancy, but the susceptibility of HPA axis as well as learning and memory function is increased under chronic stress. \u0000 \u0000 \u0000Key words: \u0000Fluoxetine; Learning and memory; Hypothalamic-pituitary-adrenal axis; Chronic stress","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"29 1","pages":"2-7"},"PeriodicalIF":0.0,"publicationDate":"2020-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45620768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-20DOI: 10.3760/CMA.J.CN371468-20190715-00461
Chunmian Chen, Deguo Jiang, Ce Chen, Xiaoyan Ma, Fuqiang Mao
Objective To evaluate the reliability and validity of Chinese version of Glasgow antipsychotics side-effect scale (GASS). Methods Totally 200 patients diagnosed as schizophrenia following the criteria of DSM-IV were enrolled in the study.Cronbach’s α was used to investigate the internal consistency of GASS.Exploring factor analysis was used to examine the construct validity.Pearson correlation analysis between GASS and TESS and CGI sub-scale of side effect were conducted to evaluate the criterion validity.Based on clinical criteria, the sensitivity and specificity and ROC curve was calculated so as to establish the cut-off point of the scale and test discrimination validity. Results For reliability, Cronbach’s α ws 0.926, indicating that GASS had a good internal consistency.Four main factors were extracted by exploratory factor analysis which were extrapyramidal side effect factor, genitourinary side effect factor, anticholinergic side effect factor, over sedation and cardiovascular side effect factor.For validity, exploring analysis demonstrated that nineteen item of the scale has relatively higher factor load on the principal factor (0.531-0.972), suggesting that the scale had a good construct validity.The total score of the GASS was positively correlated with that of TESS and CGI subscale of side effects(r=0.90, P<0.05; r=0.87, P<0.05). The cut-off point of experimental validity of GASS for mild antipsychotics side effects was determined as ≥1.With this cut-off point, GASS had both high sensitivity (96.3%) and high specificity (70.7%), area under curve (AUC) were 0.78.The cut-off point of GASS for moderate antipsychotics side effects was determined as ≥20, with the sensitivity and specificity of GASS were 86.3% and 84.7%, AUC were 0.92.When the cut-off point of GASS for severe antipsychotics side effects was determined as ≥41, GASS had both high sensitivity (92.1 %) and high specificity (96.3 %), AUC were 0.96. Conclusion GASS has good reliability and validity and can reflect the side effects of antipsychotics, and it can be adopted as a useful instrument to evaluate the severity of side effects of antipsychotics. Key words: Atypical antipsychotics; Side-effect; Rating scale; Validity; Reliability
{"title":"Validity and reliability evaluation of Chinese version of Glasgow antipscyhotics side-effect scale based on the experience of schizophrenia patients","authors":"Chunmian Chen, Deguo Jiang, Ce Chen, Xiaoyan Ma, Fuqiang Mao","doi":"10.3760/CMA.J.CN371468-20190715-00461","DOIUrl":"https://doi.org/10.3760/CMA.J.CN371468-20190715-00461","url":null,"abstract":"Objective \u0000To evaluate the reliability and validity of Chinese version of Glasgow antipsychotics side-effect scale (GASS). \u0000 \u0000 \u0000Methods \u0000Totally 200 patients diagnosed as schizophrenia following the criteria of DSM-IV were enrolled in the study.Cronbach’s α was used to investigate the internal consistency of GASS.Exploring factor analysis was used to examine the construct validity.Pearson correlation analysis between GASS and TESS and CGI sub-scale of side effect were conducted to evaluate the criterion validity.Based on clinical criteria, the sensitivity and specificity and ROC curve was calculated so as to establish the cut-off point of the scale and test discrimination validity. \u0000 \u0000 \u0000Results \u0000For reliability, Cronbach’s α ws 0.926, indicating that GASS had a good internal consistency.Four main factors were extracted by exploratory factor analysis which were extrapyramidal side effect factor, genitourinary side effect factor, anticholinergic side effect factor, over sedation and cardiovascular side effect factor.For validity, exploring analysis demonstrated that nineteen item of the scale has relatively higher factor load on the principal factor (0.531-0.972), suggesting that the scale had a good construct validity.The total score of the GASS was positively correlated with that of TESS and CGI subscale of side effects(r=0.90, P<0.05; r=0.87, P<0.05). The cut-off point of experimental validity of GASS for mild antipsychotics side effects was determined as ≥1.With this cut-off point, GASS had both high sensitivity (96.3%) and high specificity (70.7%), area under curve (AUC) were 0.78.The cut-off point of GASS for moderate antipsychotics side effects was determined as ≥20, with the sensitivity and specificity of GASS were 86.3% and 84.7%, AUC were 0.92.When the cut-off point of GASS for severe antipsychotics side effects was determined as ≥41, GASS had both high sensitivity (92.1 %) and high specificity (96.3 %), AUC were 0.96. \u0000 \u0000 \u0000Conclusion \u0000GASS has good reliability and validity and can reflect the side effects of antipsychotics, and it can be adopted as a useful instrument to evaluate the severity of side effects of antipsychotics. \u0000 \u0000 \u0000Key words: \u0000Atypical antipsychotics; Side-effect; Rating scale; Validity; Reliability","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"29 1","pages":"79-83"},"PeriodicalIF":0.0,"publicationDate":"2020-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47258652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-20DOI: 10.3760/CMA.J.CN371468-20190527-00343
Yao Wu, Zhiguo Hu, Hongyan Liu
Attention deficit hyperactivity disorder (ADHD) is a kind of mental development disorder with high prevalence. Its core symptoms are attention deficit, hyperactivity and impulse.Previous studies mainly focused on the executive function and cognitive control of ADHD. Since emotion dysregulation in ADHD results in a lot of negative consequences, such as social interaction, coping with frustration and parent-child relationship, more and more researchers believe that the lack of emotional regulation ability is likely to be an important reason for ADHD patients' inability to focus attention and hyperactive impulse behavior in recent years.At the behavioral level, ADHD patients' emotion dysregulation is mainly reflected in emotional impulsivity, emotional lability and negative emotionality.At the neurophysiological level, emotion dysregulation in ADHD patients was found to be related to heart rate variability, respiratory sinus arrhythmia, late positive component LPP and activity abnormality of resting state neural network. Some researchers have proposed the " cold" and " hot" executive function theory of ADHD, in which the " hot" regulatory circuit is associated with the processing the emotional regulation process. Future studies are needed to explore the maintaining difficulty and inducing positive emotion in ADHD, and the influence of comorbidities in ADHD. Moreover, researchers should combine neurophysiological method and family study to clarify the brain mechanism and its genetic basis underlying emotion dysregulation in ADHD patients. Key words: Attention deficit hyperactivity disorder; Emotion regulation; Impulsivity; Inhibition; Brain mechanism
{"title":"Emotion dysregulation and mechanisms in attention deficit hyperactivity disorder","authors":"Yao Wu, Zhiguo Hu, Hongyan Liu","doi":"10.3760/CMA.J.CN371468-20190527-00343","DOIUrl":"https://doi.org/10.3760/CMA.J.CN371468-20190527-00343","url":null,"abstract":"Attention deficit hyperactivity disorder (ADHD) is a kind of mental development disorder with high prevalence. Its core symptoms are attention deficit, hyperactivity and impulse.Previous studies mainly focused on the executive function and cognitive control of ADHD. Since emotion dysregulation in ADHD results in a lot of negative consequences, such as social interaction, coping with frustration and parent-child relationship, more and more researchers believe that the lack of emotional regulation ability is likely to be an important reason for ADHD patients' inability to focus attention and hyperactive impulse behavior in recent years.At the behavioral level, ADHD patients' emotion dysregulation is mainly reflected in emotional impulsivity, emotional lability and negative emotionality.At the neurophysiological level, emotion dysregulation in ADHD patients was found to be related to heart rate variability, respiratory sinus arrhythmia, late positive component LPP and activity abnormality of resting state neural network. Some researchers have proposed the \" cold\" and \" hot\" executive function theory of ADHD, in which the \" hot\" regulatory circuit is associated with the processing the emotional regulation process. Future studies are needed to explore the maintaining difficulty and inducing positive emotion in ADHD, and the influence of comorbidities in ADHD. Moreover, researchers should combine neurophysiological method and family study to clarify the brain mechanism and its genetic basis underlying emotion dysregulation in ADHD patients. \u0000 \u0000Key words: \u0000Attention deficit hyperactivity disorder; Emotion regulation; Impulsivity; Inhibition; Brain mechanism","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"29 1","pages":"84-88"},"PeriodicalIF":0.0,"publicationDate":"2020-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44665258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective To investigate the effect of Chinese reading aloud training (c-RAT) on cognitive function and activities of daily living in patients with vascular cognitive impairment no dementia (VCIND). Methods From January 2018 to January 2019, totally 80 patients with VCIND in the General Hospital of Xingtai Mining Group were enrolled.Subjects were randomized grouped into c-RAT group (n=43) and control group (n=37). The c-RAT group was asked to read aloud the Chinese paper for 5 days a week for 12 weeks.At the time of enrollment and 12 weeks after the intervention, the Montreal cognitive assessment (MoCA), trail making test (TMT), auditory verb learn test (AVLT), digit symbol substitution test (DSST) and modified Barthel index (MBI) were filled out. Results Compared with control group, the difference of D-value in c-RAT group was statistically significant in MoCA total scores(4.00(2.00), 1.50(0.50), Z=3.012, P=0.003), scores of MoCA-Visual space execution (2.00(1.00), 0.00(2.00), Z=2.787, P=0.008), MoCA-attention (1.00(1.00), 0.00(0.50), Z=2.369, P=0.022), MoCA-language (1.00(1.00), 0.00(0.75), Z=3.049, P=0.000)and MoCA-delayed recall(2.00(2.00), 0.00(1.00), Z=2.043, P=0.014), TMT-A scores (-8.00(23.00), 10.50(30.25), Z=2.120, P=0.039), AVLT scores (1earning)(3.00(2.00), 0.50(0.75), Z=2.266, P=0.039) , AVLT scores (recall)(2.00(1.00), 0.00(1.00), Z=2.974, P=0.003)、AVLT scores (recognition) (2.00(0.00), 0.50(1.50), Z=3.054, P=0.000)and DSST scores ((4.96±0.71), (2.39±0.78), t=2.572, P=0.014), while there were no significant differences in the rest parts of MoCA, TMT-B and MBI(P>0.05). The increased scores in DSST were positively correlated (r=0.205, P=0.006) with the number of reading aloud tasks finished. Conclusion C-RAT can improve general cognition, especially in information processing speed, executive function, attention and auditory memory. Key words: Learning therapy; Mild cognitive impairment; Vascular dementia; Information processing speed
{"title":"Effect of Chinese reading aloud training on cognitive function in patients with vascular cognitive impairment no dementia","authors":"Wenying Li, Jing Shi, Hongye Zhu, Yanfeng Zhang, Lan-Ying Zhang, Huijun Han","doi":"10.3760/CMA.J.CN371468-20190728-00491","DOIUrl":"https://doi.org/10.3760/CMA.J.CN371468-20190728-00491","url":null,"abstract":"Objective \u0000To investigate the effect of Chinese reading aloud training (c-RAT) on cognitive function and activities of daily living in patients with vascular cognitive impairment no dementia (VCIND). \u0000 \u0000 \u0000Methods \u0000From January 2018 to January 2019, totally 80 patients with VCIND in the General Hospital of Xingtai Mining Group were enrolled.Subjects were randomized grouped into c-RAT group (n=43) and control group (n=37). The c-RAT group was asked to read aloud the Chinese paper for 5 days a week for 12 weeks.At the time of enrollment and 12 weeks after the intervention, the Montreal cognitive assessment (MoCA), trail making test (TMT), auditory verb learn test (AVLT), digit symbol substitution test (DSST) and modified Barthel index (MBI) were filled out. \u0000 \u0000 \u0000Results \u0000Compared with control group, the difference of D-value in c-RAT group was statistically significant in MoCA total scores(4.00(2.00), 1.50(0.50), Z=3.012, P=0.003), scores of MoCA-Visual space execution (2.00(1.00), 0.00(2.00), Z=2.787, P=0.008), MoCA-attention (1.00(1.00), 0.00(0.50), Z=2.369, P=0.022), MoCA-language (1.00(1.00), 0.00(0.75), Z=3.049, P=0.000)and MoCA-delayed recall(2.00(2.00), 0.00(1.00), Z=2.043, P=0.014), TMT-A scores (-8.00(23.00), 10.50(30.25), Z=2.120, P=0.039), AVLT scores (1earning)(3.00(2.00), 0.50(0.75), Z=2.266, P=0.039) , AVLT scores (recall)(2.00(1.00), 0.00(1.00), Z=2.974, P=0.003)、AVLT scores (recognition) (2.00(0.00), 0.50(1.50), Z=3.054, P=0.000)and DSST scores ((4.96±0.71), (2.39±0.78), t=2.572, P=0.014), while there were no significant differences in the rest parts of MoCA, TMT-B and MBI(P>0.05). The increased scores in DSST were positively correlated (r=0.205, P=0.006) with the number of reading aloud tasks finished. \u0000 \u0000 \u0000Conclusion \u0000C-RAT can improve general cognition, especially in information processing speed, executive function, attention and auditory memory. \u0000 \u0000 \u0000Key words: \u0000Learning therapy; Mild cognitive impairment; Vascular dementia; Information processing speed","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"29 1","pages":"44-49"},"PeriodicalIF":0.0,"publicationDate":"2020-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45635356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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