中华行为医学与脑科学杂志最新文献

{"title":"Cognitive function characteristics in patients with myasthenia gravis","authors":"Jing Wang, Xin Li, Li-min Li, Lin-Jie Zhang, Li Yang","doi":"10.3760/CMA.J.CN371468-20191015-00755","DOIUrl":"https://doi.org/10.3760/CMA.J.CN371468-20191015-00755","url":null,"abstract":"Objective \u0000To evaluate the cognitive function characteristics in patients with myasthenia gravis(MG). \u0000 \u0000 \u0000Methods \u0000The cognitive function of 83 MG patients and 39 healthy controls (HC) were evaluated by MMSE, California verbal learning test( CVLT), brief visuospatial memory test revised(BVMT-R), symbol digit modalities test(SDMT), benton judgment of line orientation test(BJLOT), paced auditory serial addition Test(PASAT) and verbal fluency test(VFT). The depression state was assessed by beck depression inventory (BDI). The results were compared between MG and HC groups.The effect of clinical characteristics such as disease type, comorbidities, course of disease, disease severity, and drug treatment on cognitive impairment in MG group was further analysed. \u0000 \u0000 \u0000Results \u0000The scale scores of MMSE(28(26, 29), 29(28, 30)), CVLT, BVMT-R, SDMT((37.06±12.18), (47.54±14.91)) and PASAT((32.86±10.23), (37.00±8.82)) in MG were significantly lower than those in control group (P 0.05). Spearman correlation analysis showed that QMG scores were negatively correlated with SDMT scores(r=-0.234, P<0.05). MG-ADL scores were inversely correlated with total BVMT-R scores of three trials(r=-0.283, P<0.05). \u0000 \u0000 \u0000Conclusion \u0000Patients with MG suffered from cognitive impairment, mainly in memory, attention, processing speed and visual memory, which supported the hypothesis of CNS involvement in MG.Dysfunction in some cognitive domains may be related to the disease severity.Clinicians need take morce attention to early assessment, developing long-term follow-ups and appropriate intervention. \u0000 \u0000 \u0000Key words: \u0000Myasthenia gravis; Neuropsychology; Cognitive function; Depression","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"32 2","pages":"256-261"},"PeriodicalIF":0.0,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41296265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of DL-3-n-butylphthalide on cognitive function and the regulating role of Nrf2/SIRT3 signaling pathway in vascular dementia mice","authors":"Liwei Gao, Qiang Zhang, M. Li, Yanhong Dong","doi":"10.3760/CMA.J.CN371468-20190806-00527","DOIUrl":"https://doi.org/10.3760/CMA.J.CN371468-20190806-00527","url":null,"abstract":"Objective \u0000To investigate the effects of butylphthalide(NBP) on cognitive function and Nrf2 / SIRT3 signal pathway in vascular dementia (VD) mice. \u0000 \u0000 \u0000Methods \u0000Wild-type mice (Nrf2+ /+ ) were divided into sham group, model group (VD group), butylphthalide treatment group (Nrf2+ /+ NBP group), and Nrf2 gene knockout mice (Nrf2-/-) were divided into Nrf2-/-model group (Nrf2-/-VD group) and Nrf2-/-treatment group (Nrf2-/-NBP group). Both the model group and the treatment group were repeated.The bilateral common carotid arteries were ligated three times to establish a mouse model of cognitive dysfunction caused by cerebral ischemia-reperfusion.The sham group only isolated the bilateral common carotid arteries and threaded the wires, but did not block blood flow.Morris water maze experiment was used to analyze the cognitive function of mice.HE staining was used to observe the changes of neuron morphology and structure in CA1 region of hippocampus, and immunohistochemical analysis was used to analyze the positive expression of caspase 3 and caspase 9 in mouse CA1 region of hippocampus.Western blot was used to detect mouse hippocampus Nrf2, p62, LC3, SIRT3 protein expression. \u0000 \u0000 \u0000Results \u0000(1) In Morris water maze experiment: compared with VD group, the escape latency of Sham group and Nrf2+ /+ NBP group was significantly shorter on the 5th day ((20.69±8.91) s, (7.58±9.47)s, (8.41±12.20)s; q=3.58, 5.07, both P 0.05). (2) Pathological results showed that, compared with VD group, the damage of pyramidal neurons in CA1 area of hippocampus in Sham group and Nrf2+ /+ NBP group was lighter, and that in Nrf2-/- VD group was more serious, and the improvement of neuron morphology was not obvious after NBP treatment.(3) The expression of apoptosis: compared with VD group, the expression of caspase-3 and caspase-9 in the CA1 area of hippocampus in Sham group and Nrf2+ /+ NBP group were significantly lower, and those in Nrf2-/-VD group were significantly higher (t=3.48, 2.95, 3.46, 2.93, -2.99, -3.77, all P 0.05). (4) Expression of related proteins: compared with VD group, Nrf2, SIRT3, p62 protein expression increased, LC3II/I ratio decreased in Nrf2+ /+ NBP group(t=-3.24, -4.04, -4.03, 3.62, all P<0.01); Nrf2, LC3II/ I ratio decreased, SIRT3, p62 protein expression increased in Sham group(t=3.44, 4.72, -3.52, -4.19, all P<0.01); Nrf2, SIRT3, p62 protein expression decreased and LC3II/I ratio increased in Nrf2-/-VD group(t=9.14, 4.20, 4.30, -3.78, all P<0.01); Compared with Nrf2-/- NBP, the expression of Nrf2, SIRT3, p62 decreased, and LC3II/I ratio increased in Nrf2-/-VD group(t=2.40, 3.24, 1.21, -1.16, all P<0.01). The expression of Nrf2, SIRT3, p62 protein in Nrf2+ /+ NBP group increased, and the ratio of LC3II/ I decreased (t=-3.29, -5.00, 6.24, all P<0.01). \u0000 \u0000 \u0000Conclusion \u0000Butylphthalide can reduce the apoptotic damage in hippocampus of VD mice and improve cognitive dysfunction caused by repeated ischemia-reperfusion injury.Regulating Nrf2 / SIRT3 pathway to","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"29 1","pages":"200-206"},"PeriodicalIF":0.0,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45137469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Silencing long non-coding RNA HCP5 increases the radiosensitivity of glioma cells by up-regulating miR-508-3p expression","authors":"Xueyuan Li, Qiankun Liu, Shanpeng Yuan, T. Liang, Wenzheng Luo, Y. Zhen, Lixin Wu, Kang Wang, Dongming Yan","doi":"10.3760/CMA.J.CN371468-20191023-00765","DOIUrl":"https://doi.org/10.3760/CMA.J.CN371468-20191023-00765","url":null,"abstract":"Objective \u0000To investigate the effect of long non-coding (lnc) RNA HCP5 on the radiation sensitivity of glioma cells and underlying mechanism. \u0000 \u0000 \u0000Methods \u0000The glioma cells U251 and U87 were irradiated with 0, 2, 4, 6, and 8 Gy rays as different doses.si-Con, si-HCP5, pcDNA, and pcDNA-HCP5 were transfected into cells U251 and U87, recorded as si-con group, si-HCP5 group, pcDNA group, and pcDNA-HCP5 group.si-Con and si-HCP5 were transfected into cells U251 and U87, and then irradiated with 4 Gy rays, respectively, recorded as IR+ si-con group and IR+ si-HCP5 group, the cells only irradiated with 4 Gy rays were recorded as IR group.After si-HCP5 with anti-miR-con and anti-miR-508-3p was co-transfected into cell U251 and U87, respectively, irradiated with 4 Gy rays, recorded as IR+ si-HCP5+ anti-miR-con group and IR+ si-HCP5+ anti-miR-508-3p group, respectively, the transfection was performed by liposome method.RT-qPCR was used to detect the expression of miR-508-3p and HCP5.Cell clone formation assay was used to detect the radiosensitivity of glioma cells.Flow cytometry was used to detect apoptosis, dual luciferase Reporter gene detection experiments detects fluorescence activity. \u0000 \u0000 \u0000Results \u0000HCP5 was highly expressed in radiation-treated glioma cells, and miR-508-3p was lowly expressed.After silenced HCP5, U251 and U87 cells had enhanced radiosensitivity and apoptotic rate((16.67±1.68) vs (3.58±0.62), t=21.929, P<0.05; (12.32±1.08) vs (4.48±0.71), t=18.198, P<0.05) was increased, and γ-H2AX( (0.45±0.04) vs (0.23±0.05), t=10.307, P<0.05; (0.38±0.04) vs (0.24±0.03), t=8.400, P<0.05), Cleaved caspase-3((0.37±0.04) vs (0.16±0.03), t=12.600, P<0.05; (0.38±0.04) vs (0.22±0.03), t=9.600, P<0.05) expressions were increased.Compared with silencing HCP5 or radiation treatment alone, silencing HCP5 and radiation treatment of U251 cells simultaneously, the apoptosis rate ((25.34±1.54) vs (16.67±1.68), t=11.413, P<0.05; (25.34±1.54) vs (11.13±1.06), t=22.802, P<0.05) was significantly increased, and γ-H2AX((0.69±0.05) vs (0.45±0.04), t=11.245, P<0.05; (0.69±0.05) vs (0.31±0.04), t=17.804, P<0.05), Cleaved caspase-3 ((0.52±0.06/0.37±0.04, t=6.240, P<0.05) (0.52±0.06/0.34±0.04, t=7.488, P<0.05) expressions were increased.The expressions of p-PI3K ((0.21±0.02) vs (0.52±0.04), t=20.795, P<0.05; (0.26±0.23 ), ( 0.67±0.07), t=5.116, P<0.05), p- AKT ((0.22±0.03) vs (0.66±0.07), t=17.332, P<0.05; (0.23±0.04) vs (0.71±0.03), t=28.800, P<0.05) in U251 and U87 cells were decreased.HCP5 can target the regulation of miR-508-3p expression; interfering with miR-508-3p reversed the effects of silent HCP5 and radiation on the radiation sensitization and apoptosis of U251 and U87 cells.It reduced the expression levels of reducing γ-H2AX and Cleaved caspase-3, while increased the expression levels of p-PI3K and p-AKT. \u0000 \u0000 \u0000Conclusion \u0000Silencing lncRNA HCP5 can enhance the radiation sensitivity of glioma cells and promote apoptosis.The mechanism may be related with the miR-508-","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"29 1","pages":"207-214"},"PeriodicalIF":0.0,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45167793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of adenosine deaminase acting on RNA in the remission of aggression behavior in socially isolated mice and the mechanism of 5-serotonin-2C receptor","authors":"Xiaonan Zhang, Weizhi Yu, Ying Xue, Hong Xu, Wei Yan, Huairui Li, Xiuli Zhai, Jinying Li, Ye Gao, Lin Gui, Deqin Yu, Zhaoyang Xiao, Yi-yuan Tang, Shengming Yin","doi":"10.3760/CMA.J.CN371468-20190712-00455","DOIUrl":"https://doi.org/10.3760/CMA.J.CN371468-20190712-00455","url":null,"abstract":"Objective \u0000To investigate the effect of adenosine deaminase acting on RNA 1 (ADAR1) on 5-serotonin-2c receptor in alleviating aggression in socially isolated mice. \u0000 \u0000 \u0000Methods \u0000Sixty healthy male BALB / c mice aged 21 days were randomly divided into six groups: social isolation group, social control group, ADAR1 inducer social isolation group, ADAR1 inhibitor social isolation group, ADAR1 inducer social control group and ADAR1 inhibitor control group.The mice fed in single cage for 4 weeks were used as social isolation model while the mice fed in group were used as control group.ADAR1 inducer (5.0×104 U/kg) and inhibitor (10 mg/kg) were given intraperitoneally to mice in the ADAR1 inducer social isolation group and the ADAR1 inhibitor social isolation group respectively.The aggressive behavior of mice was evaluated by resident-intruder test.The expression of ADAR1 and 5-serotonin-2c receptors in the brain of mice was detected by immunohistochemistry and Western blot. \u0000 \u0000 \u0000Results \u0000The attack latency of social isolation group was significantly lower than that of social control group ((43.15±6.99) s, (542.40±30.50) s; t=15.906, P<0.01), and the latency of attack ((256.70±29.49) s) in the ADAR1 inducer social isolation group was significantly higher than that in the social isolation group (t=7.046, P<0.01). The latency of attack ((15.25±2.18)s) in the ADAR1 inhibitor social isolation group was significantly lower than that in the social isolation group (t=3.809, P<0.01). The optical density of ADAR1 immunoreactive cells in the amygdala of the social isolation group mice was significantly lower than that in the corresponding brain area of the social control group (BLA: (0.038±0.002), (0.074±0.004); LaDL: (0.033±0.002), (0.060±0.002); LaVM: (0.045±0.003), (0.073±0.004); Lavl area: (0.044±0.003), (0.070±0.003); t=8.428, 9.037, 6.462, 5.698, all P<0.01). The optical density of ADAR1 immunoreactive positive cells in the amygdala (BLA: (0.060±0.003), LaDL: (0.042±0.002), LaVM: (0.056±0.004), Lavl: (0.054±0.003) in the ADAR1 inducer social isolation group was significantly higher than those in the corresponding brain area of the social isolation group mice (t=6.055, 2.876, 2.312, 2.492; all P<0.05). The expression of ADAR1 protein and 5-serotonin-2c receptor protein in amygdala of social isolation group were significantly lower than those of social isolation group (t=11.37, 12.65; P<0.01). The expression of ADAR1 protein and 5-serotonin-2c receptor protein in the amygdala of the ADAR1 inducer social isolation group were significantly higher than those of the social isolation group (t=3.02, 4.401; P<0.05). \u0000 \u0000 \u0000Conclusion \u0000ADAR1 inducer alleviates the aggressive behavior of social isolated BALB / c mice by enhancing the protein expression of 5-serotonin-2c receptor in the amygdala of social isolated BALB/c mice. \u0000 \u0000 \u0000Key words: \u0000Social isolation; Aggressive behavior; Adenosine deaminase acting on RNA 1; 5-serotonin-2C receptor; Mice","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"29 1","pages":"193-199"},"PeriodicalIF":0.0,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42152289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of music training and art training on letters-speech sounds audiovisual integration in college students","authors":"Shengnan Li, Weiping Yang","doi":"10.3760/CMA.J.CN371468-20190808-00536","DOIUrl":"https://doi.org/10.3760/CMA.J.CN371468-20190808-00536","url":null,"abstract":"Objective \u0000To investigate the effects of music training and art training on the audiovisual integration of letters-speech sounds in college students. \u0000 \u0000 \u0000Method \u0000Visual letters and auditory speech sounds were used to conduct a discrimination task test in music students, art students and ordinary college students (n=30 for each group). SPSS17.0 was used to conduct ANOVA and Race model analysis on reaction time and hit rate. \u0000 \u0000 \u0000Results \u0000(1) Reaction time: the results showed that the interaction between group and stimulus type was significant(F=7.89, P<0.01). The simple effect analysis found that all the participants reacted faster to consistent audiovisual(letters B and speech B) stimuli in comparison to unimodal stimuli, and the redundant signal effect occured.(2) Race model analysis showed that the time window of audiovisual integration were 120-130 ms in the music group, 130-190 ms in the art group, and 120-170 ms in the general group(P<0.01). The positive area (pAUC) under the Race model curve of the music group(18.95) was significantly smaller than that of the art group(159.43) and the general group(125.01)(P<0.01), and there was no significant difference between the art group and the general group(P=0.13). \u0000 \u0000 \u0000Conclusion \u0000Music training has a regulating effect on the integration of letters and speech sounds, while art training has no significant effect on it. \u0000 \u0000 \u0000Key words: \u0000Audiovisual integration; The redundant signal effect; Race model; Music training; Art training","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"29 1","pages":"266-270"},"PeriodicalIF":0.0,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44693090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research progress of immune regulation in antidepressant treatment","authors":"Peilin Wang, Nan Zhang, Simeng Ma, Zhongchun Liu","doi":"10.3760/CMA.J.CN371468-20191204-00885","DOIUrl":"https://doi.org/10.3760/CMA.J.CN371468-20191204-00885","url":null,"abstract":"In recent years, the role of inflammation in depression has received people's attention.Studies have suggested that immune disorder may play an important role in depression, and patients with depression exhibit characteristic immunophenotypes.Inflammation seems to interact with a variety of pathogenesis of depression.Therefore, immunoregulation is becoming an adjuvant therapy for depression.Clinically, not only antidepressants show anti-inflammatory effects, but also anti-inflammatory drugs show antidepressant effects, and they mainly including non-steroidal anti-inflammatory drugs, statins, and cytokine inhibitors.In addition, some non-drug treatment methods are also given immunomodulatory effects, such as electric shock therapy, vagus nerve stimulation, acupuncture and exercise therapy.However, there are still some problems in immunomodulation therapy, such as immunomodulation therapy may be only effective for some subgroups of patients, and its efficacy and safety need to be evaluated.In the future, looking for more effective biomarkers and identifying immune-inflammation-related subtype of depression, will serve to explore new diagnosis and treatment strategies. \u0000 \u0000Key words: \u0000Major depression disorder; Immunomodulation; Inflammation; Anti-inflammatory; Therapy","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"29 1","pages":"284-288"},"PeriodicalIF":0.0,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44109482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reconsideration on the multiple value of Behavior determining Health: in the perspective of the situation of COVID-19/ 中华行为医学与脑科学杂志","authors":"Lifang Zhu, Mingke Bie, Guojian Song, Zhiyin Yang","doi":"10.3760/CMA.J.ISSN.1674-6554.2020.0002","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-6554.2020.0002","url":null,"abstract":"Why has the concept of behavior determining health created more and more extensive and far-reaching influence ever since it was put forward? The reason lies in its multiple values. It is of great practical significance and has important implications for long-term health care to explore and analyze in the perspective of the situation of COVID-19 its philosophical values, cultural values, methodological values, social values and the national strategic value of \"healthy China\".","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47855941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expressions of triggering receptor expressed on myeloid cell 2 in different brain regions in tyrosine kinase binding protein gene knockout mice","authors":"Tongxiao Xu, Zhao-xia Wang, Yanxin Li, Kuo H. Yang, Wei Zhang, Wei Li, Yanlei Hao","doi":"10.3760/CMA.J.CN371468-20191025-00782","DOIUrl":"https://doi.org/10.3760/CMA.J.CN371468-20191025-00782","url":null,"abstract":"Objective \u0000To compare the expression of myeloid cell trigger receptor expressed on myoid cell 2 (TREM2) in different brain regions of tyrosine kinase binding protein(TYROBP) knockout mice and wild-type mice at different months of age, and to explore the relationship between TREM2, TYROBP and early onset Alzheimer's disease(EOAD). \u0000 \u0000 \u0000Methods \u0000Healthy TYROBP gene knockout mice were divided into three groups according to the results of gene sequencing: the homozygous (TYROBP-/-) group, the heterozygous (TYROBP-/+ ) group, and the wild type (WT) group.Western blot and RT-qPCR were used to detect the expression of TREM2 in prefrontal cortex and hippocampus of 2, 4 and 6 month old mice in the three groups and with 10 in each group at each time point. \u0000 \u0000 \u0000Results \u0000(1) In the prefrontal cortex: Western blot and RT-qPCR results showed that compared with WT mice (2-month-old: (0.993±0.048), (1.654±0.033); 4-month-old: (0.503±0.019), (2.169±0.023); 6-month-old: (0.600±0.036), (1.468±0.057)), the levels of TREM2 protein and mRNA in 2-month-old TYROBP-/+ group ((0.746±0.062), (1.137±0.067)) and TYROBP-/- group ((0.661±0.028), (0.644±0.012)) were decreased.While in 4-month-old and 6-month-old TYROBP-/+ group (4-month-old: (1.140±0.006), (5.483±0.088); 6-month-old: (0.827±0.043), (3.020±0.082)) and TYROBP-/- group (4-month-old: (1.071±0.010), (3.012±0.150); 6-month-old: (0.627±0.026), (1.633±0.027)) were increased, especially in 4-month-old mice and the differences were statistically significant (F=12.946, 134.445; 725.318, 289.202; 12.172, 202.791; all P<0.05). (2) In the hippocampus: Western blot results showed that compared with WT mice (2-month-old: (1.268±0.036); 4-month-old: (0.813±0.010); 6-month-old: (0.312±0.021)), the level of TREM2 protein in 2-month-old TYROBP-/+ group ((0.804±0.034)) and TYROBP-/- group ((0.534±0.020)) were decreased.While in 4-month-old and 6-month-old TYROBP-/+ group ((0.932±0.011); (0.769±0.031)) and TYROBP-/- group ((0.910±0.014); (0.609±0.018)) were increased, especially in 4-month-old mice and the differences were statistically significant (F=142.807; 27.884; 94.067; all P<0.05). \u0000 \u0000 \u0000Conclusion \u0000The expression level of TREM2 decreases in 2-month-old TYROBP gene knockout mice while increases in 4-month-old and 6-month-old TYROBP gene knockout mice.It is presumed that TREM2/TYROBP signal pathway participates in the pathological process of EOAD and plays different roles in different pathological stages of EOAD. \u0000 \u0000 \u0000Key words: \u0000Tyrosine kinase binding protein; Triggering receptor expressed on myeloid cell 2; Alzheimer's disease; Mice","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"29 1","pages":"102-108"},"PeriodicalIF":0.0,"publicationDate":"2020-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49333881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of behavioral intervention on scratching behavior in patients with senile pruritus","authors":"Xiaopei Du, Chen Shaoxiu, Z. Xia, Duhong Chen, Wang Chao","doi":"10.3760/CMA.J.CN371468-20190516-00326","DOIUrl":"https://doi.org/10.3760/CMA.J.CN371468-20190516-00326","url":null,"abstract":"Objective \u0000To explore the impact of behavioral intervention on scratching behavior of patients with senile pruritus. \u0000 \u0000 \u0000Methods \u0000One hundred cases of senile pruritus were randomly divided into observation group (n=50) and control group (n=50). All subjects received oral antihistamine.The observation group received behavioral intervention based on the trans-theoretical model, and the control group received routine health education.Visual analogue scale (VAS), Pittsburgh sleep quality index (PSQI) and dermatology life quality index (DLQI) were used to compare the itching symptoms, sleep quality and quality of life of senile pruritus patients in the two groups. \u0000 \u0000 \u0000Results \u0000After 6 months intervention, the change of scratching behavior in the observation group((1.96±1.54), (8.83±2.05), (10.46±2.24)) was significantly better than those in the control group((4.68±1.48), (12.89±2.02), (14.62±2.12)), and the differences were statistically significant (all P<0.01). \u0000 \u0000 \u0000Conclusion \u0000Health intervention based on trans-theoretical model can effectively change scratching behavior, relieve itching symptoms, improve sleep quality and the quality of life of senile pruritus patients. \u0000 \u0000 \u0000Key words: \u0000Senile pruritus; Scratching behavior; Trans-theoretical model; Quality of life","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"29 1","pages":"148-152"},"PeriodicalIF":0.0,"publicationDate":"2020-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46458067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes of resting state fMRI brain imaging in patients with depression after antidepressant treatment","authors":"Jian Cui, Yun Wang, Yuan Zhou, Gang Wang","doi":"10.3760/CMA.J.CN371468-20190523-00335","DOIUrl":"https://doi.org/10.3760/CMA.J.CN371468-20190523-00335","url":null,"abstract":"Antidepressant therapy is effective for patients with major depressive disorder, however the mechanism is unclear and it is difficult to predict the efficacy objectively. At present, the changes of local spontaneous brain activity in patients with major depressive disorder after antidepressant treatment are mostly located in the dorsolateral prefrontal cortex, ventromedial prefrontal cortex, anterior cingulate gyrus and precuneus. The changes of brain function interaction involved in emotional circuit, default mode network, central executive network and hypothalamus-pituitary-adrenal axis.Future researches should optimize the experimental design, enlarge the sample size, reduce the sample heterogeneity, and compare the effects of different types of antidepressants. This paper reviews the effects of antidepressant therapy on brain function in patients with major depressive disorder from the perspective of resting fMRI, to promote our understanding of the mechanism of antidepressant therapy and to promote the discovery of objective biomarkers which can predict the response of antidepressant therapy. \u0000 \u0000 \u0000Key words: \u0000Major depressive disorder; Antidepressants; Resting state; Functional magnetic resonance imaging","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"29 1","pages":"177-182"},"PeriodicalIF":0.0,"publicationDate":"2020-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47063603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}