Pub Date : 2019-10-20DOI: 10.3760/CMA.J.ISSN.1674-6554.2019.10.004
Zeng-xin Zhang
Objective To explore the effect of sleep nursing intervention on infants' sleep status and gross motor development. Methods Eighty-nine normal infants aged 8-9 months were randomly divided into two groups: experimental group (n=45) and control group (n=44). The control group received general family nursing intervention, while the experimental group received sleep nursing intervention.The whole intervention lasted for 56 consecutive natural days.Before and after the intervention, polysomnography (PSG) was used to monitor the electrophysiology during sleep, and Gesell development assessment scale was used to assess the gross motor development of the subjects. Results There were no significant difference in sleep duration ((79.6±15.0)min, (78.3±20.4)min), REM sleep ((28.3±5.9)%, (28.2±9.0)%), NREM sleep((71.2±3.6)%, (72.6±5.1)%), deep sleep ((13.0±2.7)%, (13.6±3.7)%), sleep latency ((9.1±3.6)min, (8.7±2.9)min)and sleep efficiency ((78.6±1.9)%, (84.4±5.5)%)before and after the intervention in the control group (all P>0.05). The sleep duration ((82.7±13.4) min, (95.6±12.1) min), the proportion of deep sleep((10.4±4.7)%, (16.6±3.0)%), the proportion of NREM period((74.9±1.6)%, (76.9±1.0)%), the sleep efficiency((82.3±2.6)%, (89.4±3.7)%) in the experimental group were significantly different before and after the intervention(P<0.05). The differences value of the total sleep duration, NREM sleep proportion, deep sleep proportion and sleep efficiency before and after the intervention in the experimental group were significantly higher than those in the control group (P<0.05). The difference value of gross motor development between the two groups before and after intervention was statistically significant (test group (6.0±3.0), control group (2.0±1.5), t=4.687, P<0.05). Conclusion Sleep nursing intervention can improve the proportion of deep sleep in infants and improve the development level of gross exercise.The community health service can make sleep nursing intervention plan according to different families and infants' psychological development to optimize infants' deep sleep and promote the level of gross motor development. Key words: Sleep; Family nursing; Gross motor development
{"title":"Effect of the sleep nursing intervention on sleep status and gross motor development of infants","authors":"Zeng-xin Zhang","doi":"10.3760/CMA.J.ISSN.1674-6554.2019.10.004","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-6554.2019.10.004","url":null,"abstract":"Objective \u0000To explore the effect of sleep nursing intervention on infants' sleep status and gross motor development. \u0000 \u0000 \u0000Methods \u0000Eighty-nine normal infants aged 8-9 months were randomly divided into two groups: experimental group (n=45) and control group (n=44). The control group received general family nursing intervention, while the experimental group received sleep nursing intervention.The whole intervention lasted for 56 consecutive natural days.Before and after the intervention, polysomnography (PSG) was used to monitor the electrophysiology during sleep, and Gesell development assessment scale was used to assess the gross motor development of the subjects. \u0000 \u0000 \u0000Results \u0000There were no significant difference in sleep duration ((79.6±15.0)min, (78.3±20.4)min), REM sleep ((28.3±5.9)%, (28.2±9.0)%), NREM sleep((71.2±3.6)%, (72.6±5.1)%), deep sleep ((13.0±2.7)%, (13.6±3.7)%), sleep latency ((9.1±3.6)min, (8.7±2.9)min)and sleep efficiency ((78.6±1.9)%, (84.4±5.5)%)before and after the intervention in the control group (all P>0.05). The sleep duration ((82.7±13.4) min, (95.6±12.1) min), the proportion of deep sleep((10.4±4.7)%, (16.6±3.0)%), the proportion of NREM period((74.9±1.6)%, (76.9±1.0)%), the sleep efficiency((82.3±2.6)%, (89.4±3.7)%) in the experimental group were significantly different before and after the intervention(P<0.05). The differences value of the total sleep duration, NREM sleep proportion, deep sleep proportion and sleep efficiency before and after the intervention in the experimental group were significantly higher than those in the control group (P<0.05). The difference value of gross motor development between the two groups before and after intervention was statistically significant (test group (6.0±3.0), control group (2.0±1.5), t=4.687, P<0.05). \u0000 \u0000 \u0000Conclusion \u0000Sleep nursing intervention can improve the proportion of deep sleep in infants and improve the development level of gross exercise.The community health service can make sleep nursing intervention plan according to different families and infants' psychological development to optimize infants' deep sleep and promote the level of gross motor development. \u0000 \u0000 \u0000Key words: \u0000Sleep; Family nursing; Gross motor development","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"28 1","pages":"881-886"},"PeriodicalIF":0.0,"publicationDate":"2019-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46015191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-10-20DOI: 10.3760/CMA.J.ISSN.1674-6554.2019.10.017
Yiliang Zhang, S. Zhong, Shunkai Lai
Major depressive disorder (MDD) is one of the most common psychiatric disorders.It is characterized by emotional, cognitive, and physical symptoms which can also cause severe disability and disease burden. The current study found that patients with MDD have cognitive impairment in both acute and remission phases, which seriously affect the prognosis of patients. The impairment of visual cognitive function greatly affects the social function of MDD patients and the current researches showed that visual cognitive impairment of MDD patients is closely related to the functional connection in the brain, which can be reflected by different degrees of neuroimaging changes in the frontal, occipital, temporal, and parietal regions.The change of visual cognitive function in patients with MDD is mainly influenced by the frontal lobe and the occipital lobe, which may be related to the large number of visual cortex in the anatomy of the two brain regions. The activation of the frontal lobe may be positively related to the patient's visual cognitive impairment; the reduction of the occipital lobe activity may have an impact on the visual process and may be the starting factor for cognitive impairment. The active enhancement of the parietal region plays an important role in the visual short-term memory. In addition, the temporo-parietal junction is also found to be involved in the processing of visual and working memory, and the activation of temporal lobe and parietal lobe can be observed.This review summarizes recent researches at home and abroad and reveals the visual perception of MDD patients in different ways in each different brain regions. Key words: Major depressive disorder; Visual cognitive; Brain imaging
{"title":"The brain imaging mechanisms of visual cognitive impairment in depression","authors":"Yiliang Zhang, S. Zhong, Shunkai Lai","doi":"10.3760/CMA.J.ISSN.1674-6554.2019.10.017","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-6554.2019.10.017","url":null,"abstract":"Major depressive disorder (MDD) is one of the most common psychiatric disorders.It is characterized by emotional, cognitive, and physical symptoms which can also cause severe disability and disease burden. The current study found that patients with MDD have cognitive impairment in both acute and remission phases, which seriously affect the prognosis of patients. The impairment of visual cognitive function greatly affects the social function of MDD patients and the current researches showed that visual cognitive impairment of MDD patients is closely related to the functional connection in the brain, which can be reflected by different degrees of neuroimaging changes in the frontal, occipital, temporal, and parietal regions.The change of visual cognitive function in patients with MDD is mainly influenced by the frontal lobe and the occipital lobe, which may be related to the large number of visual cortex in the anatomy of the two brain regions. The activation of the frontal lobe may be positively related to the patient's visual cognitive impairment; the reduction of the occipital lobe activity may have an impact on the visual process and may be the starting factor for cognitive impairment. The active enhancement of the parietal region plays an important role in the visual short-term memory. In addition, the temporo-parietal junction is also found to be involved in the processing of visual and working memory, and the activation of temporal lobe and parietal lobe can be observed.This review summarizes recent researches at home and abroad and reveals the visual perception of MDD patients in different ways in each different brain regions. \u0000 \u0000 \u0000Key words: \u0000Major depressive disorder; Visual cognitive; Brain imaging","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"28 1","pages":"951-955"},"PeriodicalIF":0.0,"publicationDate":"2019-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47403851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-10-20DOI: 10.3760/CMA.J.ISSN.1674-6554.2019.10.006
Shanshan Wang, Rong Fu, Xiao-hua Huang, Jie Liu
Objective To investigate the effects of acute fatigue on the outcome of aged patients with cerebral infarction. Methods The Fatigue Severity Scale was used to investigate the incidence of fatigue in 240 elderly patients with acute cerebral infarction, to assess the outcome of the patients at discharge and one year after discharge, and to analyze the effect of acute fatigue on the functional recovery and survival of patients. Results Totally 89 patients (37.1%) suffered from acute fatigue.Multivariate Logistic regression analysis showed that high admission NIHSS score(OR=2.472, 95%CI= 1.931-3.164)and acute post-stroke fatigue(OR=4.820, 95%CI=2.281~10.187)were the influencing factors for functional recovery of elderly patients with cerebral infarction at discharge(P<0.01). High admission NIHSS score(OR=1.674, 95%CI=1.411-1.985), acute post-stroke fatigue(OR=2.123, 95%CI=1.187-3.796), mRS score≥ 2 at discharge(OR=9.822, 95%CI=4.899-19.693)and recurrence(OR=6.146, 95%CI=2.596-14.553)were independent risk factors for functional recovery of elderly patients with cerebral infarction one year after discharge (P<0.05). Multivariate Cox regression analysis showed that age (OR=1.096, 95%CI=1.027-1.169), post-stroke fatigue in acute phase OR=5.233, 95%CI=1.051-6.053)and recurrence(OR=13.983, 95%CI=2.821-49.307)were independent predictors of mortality for elderly patients with cerebral infarction (P<0.05). Conclusion Fatigue after acute stroke can effect the functional recovery and survival of elderly patients with cerebral infarction. Key words: Post-stroke fatigue; Acute phase; Cerebral infarction; Outcome
{"title":"Effects of acute fatigue on the outcome of aged patients with initial cerebral infarction","authors":"Shanshan Wang, Rong Fu, Xiao-hua Huang, Jie Liu","doi":"10.3760/CMA.J.ISSN.1674-6554.2019.10.006","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-6554.2019.10.006","url":null,"abstract":"Objective \u0000To investigate the effects of acute fatigue on the outcome of aged patients with cerebral infarction. \u0000 \u0000 \u0000Methods \u0000The Fatigue Severity Scale was used to investigate the incidence of fatigue in 240 elderly patients with acute cerebral infarction, to assess the outcome of the patients at discharge and one year after discharge, and to analyze the effect of acute fatigue on the functional recovery and survival of patients. \u0000 \u0000 \u0000Results \u0000Totally 89 patients (37.1%) suffered from acute fatigue.Multivariate Logistic regression analysis showed that high admission NIHSS score(OR=2.472, 95%CI= 1.931-3.164)and acute post-stroke fatigue(OR=4.820, 95%CI=2.281~10.187)were the influencing factors for functional recovery of elderly patients with cerebral infarction at discharge(P<0.01). High admission NIHSS score(OR=1.674, 95%CI=1.411-1.985), acute post-stroke fatigue(OR=2.123, 95%CI=1.187-3.796), mRS score≥ 2 at discharge(OR=9.822, 95%CI=4.899-19.693)and recurrence(OR=6.146, 95%CI=2.596-14.553)were independent risk factors for functional recovery of elderly patients with cerebral infarction one year after discharge (P<0.05). Multivariate Cox regression analysis showed that age (OR=1.096, 95%CI=1.027-1.169), post-stroke fatigue in acute phase OR=5.233, 95%CI=1.051-6.053)and recurrence(OR=13.983, 95%CI=2.821-49.307)were independent predictors of mortality for elderly patients with cerebral infarction (P<0.05). \u0000 \u0000 \u0000Conclusion \u0000Fatigue after acute stroke can effect the functional recovery and survival of elderly patients with cerebral infarction. \u0000 \u0000 \u0000Key words: \u0000Post-stroke fatigue; Acute phase; Cerebral infarction; Outcome","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"28 1","pages":"893-897"},"PeriodicalIF":0.0,"publicationDate":"2019-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43868481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-10-20DOI: 10.3760/CMA.J.ISSN.1674-6554.2019.10.005
Li-Hong Tao, Xinjiang Zhang, Z. Duan, Yihui Liu
Objective To investigate the correlation between sexual dysfunction(SD)and estrogen receptor (ER) gene polymorphism in Chinese Han women with epilepsy (WWE). Methods A total of 112 married Chinese Han women with epilepsy were collected from outpatients and inpatients of the Affiliated Hospital of Yangzhou University, and 120 matched healthy women were taken as the control group.WWE were treated with antiepileptic drugs (AEDs) for one year or more.The Chinese version of female sexual function index (FSFI) was used to investigate the sexual function of the subjects.The chemiluminescence method was used to detect the sex hormones levels such as prolactin(PRL), follicle-stimulating hormone(FSH), luteinizing hormone(LH), estradiol(E2), progesterone(P) and testosterone(T). Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to determine the ER gene polymorphism.Chi-square test, t-test and binary logistic regression were used for statistical analysis.The differences of the sexual function, sex hormone, ER genotype, and allele frequency were compared between the two groups.And the correlation between SD and ER gene polymorphism was analyzed. Results (1) The proportion of SD in Chinese Han WWE was 70.5%(79/112), while that was 24.2%(29/120) in the control group.The serum prolactin (PRL) level in the WWE group was significantly higher than that in the control group (t=2.072, P=0.039). (2) The allele frequencies of ER PvuII C and AluI A in the WWE group were significantly higher than those in the control group (P=0.001; P=0.001). (3) Binary logistic regression analysis showed that PvuII CC genotype and serum testosterone level were independently correlated with SD (OR=6.074, 95%CI: 1.257-29.352, P=0.025; OR=0.412, 95%CI: 0.201-0.842, P=0.015). Conclusion ERα PvuII polymorphism may be related to the susceptibility of SD in Chinese Han WWE, and PvuII CC genotype may be the risk genotype of SD in WWE. Key words: Epilepsy; Women; Sexual dysfunction; Sex hormone; Estrogen receptor
{"title":"The correlation of sexual dysfunction and estrogen receptor gene polymorphism in Chinese Han women with epilepsy","authors":"Li-Hong Tao, Xinjiang Zhang, Z. Duan, Yihui Liu","doi":"10.3760/CMA.J.ISSN.1674-6554.2019.10.005","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-6554.2019.10.005","url":null,"abstract":"Objective \u0000To investigate the correlation between sexual dysfunction(SD)and estrogen receptor (ER) gene polymorphism in Chinese Han women with epilepsy (WWE). \u0000 \u0000 \u0000Methods \u0000A total of 112 married Chinese Han women with epilepsy were collected from outpatients and inpatients of the Affiliated Hospital of Yangzhou University, and 120 matched healthy women were taken as the control group.WWE were treated with antiepileptic drugs (AEDs) for one year or more.The Chinese version of female sexual function index (FSFI) was used to investigate the sexual function of the subjects.The chemiluminescence method was used to detect the sex hormones levels such as prolactin(PRL), follicle-stimulating hormone(FSH), luteinizing hormone(LH), estradiol(E2), progesterone(P) and testosterone(T). Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to determine the ER gene polymorphism.Chi-square test, t-test and binary logistic regression were used for statistical analysis.The differences of the sexual function, sex hormone, ER genotype, and allele frequency were compared between the two groups.And the correlation between SD and ER gene polymorphism was analyzed. \u0000 \u0000 \u0000Results \u0000(1) The proportion of SD in Chinese Han WWE was 70.5%(79/112), while that was 24.2%(29/120) in the control group.The serum prolactin (PRL) level in the WWE group was significantly higher than that in the control group (t=2.072, P=0.039). (2) The allele frequencies of ER PvuII C and AluI A in the WWE group were significantly higher than those in the control group (P=0.001; P=0.001). (3) Binary logistic regression analysis showed that PvuII CC genotype and serum testosterone level were independently correlated with SD (OR=6.074, 95%CI: 1.257-29.352, P=0.025; OR=0.412, 95%CI: 0.201-0.842, P=0.015). \u0000 \u0000 \u0000Conclusion \u0000ERα PvuII polymorphism may be related to the susceptibility of SD in Chinese Han WWE, and PvuII CC genotype may be the risk genotype of SD in WWE. \u0000 \u0000 \u0000Key words: \u0000Epilepsy; Women; Sexual dysfunction; Sex hormone; Estrogen receptor","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"28 1","pages":"887-892"},"PeriodicalIF":0.0,"publicationDate":"2019-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45134468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-10-20DOI: 10.3760/CMA.J.ISSN.1674-6554.2019.10.007
Chenghui Yang, Bo Zhou, Fan Zhou, Shuya Pan, Luyao Wang, Xu-Hui Zhong, Yulan Huang
Objective To explore the perception and evaluation of patients with somatic symptom disorder about their own diseases and treatment, and to provide theoretical basis for design of illness perception questionnaire for patients with somatic symptoms disorder. Methods A semi-structured interview was conducted among 15 initial and untreated patients with somatic symptom disorder using the descriptive qualitative study. The data were sorted, encoded, classified, summarized and refined using MAXQDA10 software. Results Three main themes and six sub-themes of illness perception in patients with somatic symptom disorder were analyzed and sorted out: (1) symptom recognition: including three sub-themes, low understanding of the disease and denial of somatic symptoms as mental illness; (2)drug taking concerns: including two sub-themes worrying about side effects of drugs, drug addiction and having difficulty to stick to the long-term regular medication; (3)emotional reaction: including the obvious negative emotions of depression and helplessness sub-theme. Conclusion Patients with somatic symptom disorder have a general bias in illness perception, which has a potential adverse effect on treatment compliance. Therefore, it is necessary for clinical medical staff to early estimate patients’illness perception, and carry out mental health education and rational emotional behavior therapy. Key words: Somatic symptom disorder; Illness perception; Qualitative research; Compliance; Intervention
{"title":"Illness perception in patients with somatic symptom disorder: a qualitative study","authors":"Chenghui Yang, Bo Zhou, Fan Zhou, Shuya Pan, Luyao Wang, Xu-Hui Zhong, Yulan Huang","doi":"10.3760/CMA.J.ISSN.1674-6554.2019.10.007","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-6554.2019.10.007","url":null,"abstract":"Objective \u0000To explore the perception and evaluation of patients with somatic symptom disorder about their own diseases and treatment, and to provide theoretical basis for design of illness perception questionnaire for patients with somatic symptoms disorder. \u0000 \u0000 \u0000Methods \u0000A semi-structured interview was conducted among 15 initial and untreated patients with somatic symptom disorder using the descriptive qualitative study. The data were sorted, encoded, classified, summarized and refined using MAXQDA10 software. \u0000 \u0000 \u0000Results \u0000Three main themes and six sub-themes of illness perception in patients with somatic symptom disorder were analyzed and sorted out: (1) symptom recognition: including three sub-themes, low understanding of the disease and denial of somatic symptoms as mental illness; (2)drug taking concerns: including two sub-themes worrying about side effects of drugs, drug addiction and having difficulty to stick to the long-term regular medication; (3)emotional reaction: including the obvious negative emotions of depression and helplessness sub-theme. \u0000 \u0000 \u0000Conclusion \u0000Patients with somatic symptom disorder have a general bias in illness perception, which has a potential adverse effect on treatment compliance. Therefore, it is necessary for clinical medical staff to early estimate patients’illness perception, and carry out mental health education and rational emotional behavior therapy. \u0000 \u0000 \u0000Key words: \u0000Somatic symptom disorder; Illness perception; Qualitative research; Compliance; Intervention","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"28 1","pages":"898-902"},"PeriodicalIF":0.0,"publicationDate":"2019-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49395820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-10-20DOI: 10.3760/CMA.J.ISSN.1674-6554.2019.10.001
Pei Sun, C. Luo, Qingqing Geng, Qian Zhang, Shuan-Chih Chen, Wendi Wang, Xiang Wang, Yifeng Du, C. Qu
Objective To explore the effects of vascular risk factors on cognitive function among the elderly in community. Methods A cross-sectional study was conducted in 1 269 elderly people (aged 65 and over) who were randomly selected from three communities.Through face-to-face interview, cognitive function was assessed by mini-mental state examination(MMSE), and blood samples were collected for laboratory examination.Logistic regression analysis was used to analyze the vascular risk factors affecting cognitive function. Results Age ((73.1±6.6), (71.3±4.9), t=4.603, P<0.05), education level (χ2=12.727, P<0.05), hypertension (χ2=9.106, P<0.05) and LDL-C (χ2=5.157, P<0.05) were significantly different in the elderly with or without mild cognitive impairment(MCI). After controlling age, gender and education, the logistic regression analysis showed that hypertension(β=0.378, P=0.006, OR(95%CI)=1.44(1.10-1.91)), systolic blood pressure ≥140 mmHg(β=0.350, P=0.011, OR(95%CI)=1.42(1.08-1.86), 1 mmHg=0.133 kPa), and high LDL-C(β=0.355, P=0.014, OR(95%CI)=1.43(1.08-1.89)) were the risk factors of MCI in the elderly in the community.Hypertension alone or high LDL-C (β=0.365, P=0.029, OR(95%CI)=1.44(1.04-2.00)) alone was risk factor for mild cognitive impairment in the elderly in the community.The risk of mild cognitive impairment in the elderly with hypertension and high LDL-C was 2.00 times higher than that in the healthy elderly (β=0.696, P<0.05, OR(95%CI)=2.00(1.36-2.97)). Conclusion Mild cognitive impairment in the elderly is closely related to hypertension and elevated LDL-C levels.Multiple vascular risk factors can further increase the risk of cognitive impairment. Key words: Cognitive impairment; Vascular risk factors; Hypertension; Elderly
{"title":"Analysis of the vascular risk factors for the elderly with mild cognitive impairment in community","authors":"Pei Sun, C. Luo, Qingqing Geng, Qian Zhang, Shuan-Chih Chen, Wendi Wang, Xiang Wang, Yifeng Du, C. Qu","doi":"10.3760/CMA.J.ISSN.1674-6554.2019.10.001","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-6554.2019.10.001","url":null,"abstract":"Objective \u0000To explore the effects of vascular risk factors on cognitive function among the elderly in community. \u0000 \u0000 \u0000Methods \u0000A cross-sectional study was conducted in 1 269 elderly people (aged 65 and over) who were randomly selected from three communities.Through face-to-face interview, cognitive function was assessed by mini-mental state examination(MMSE), and blood samples were collected for laboratory examination.Logistic regression analysis was used to analyze the vascular risk factors affecting cognitive function. \u0000 \u0000 \u0000Results \u0000Age ((73.1±6.6), (71.3±4.9), t=4.603, P<0.05), education level (χ2=12.727, P<0.05), hypertension (χ2=9.106, P<0.05) and LDL-C (χ2=5.157, P<0.05) were significantly different in the elderly with or without mild cognitive impairment(MCI). After controlling age, gender and education, the logistic regression analysis showed that hypertension(β=0.378, P=0.006, OR(95%CI)=1.44(1.10-1.91)), systolic blood pressure ≥140 mmHg(β=0.350, P=0.011, OR(95%CI)=1.42(1.08-1.86), 1 mmHg=0.133 kPa), and high LDL-C(β=0.355, P=0.014, OR(95%CI)=1.43(1.08-1.89)) were the risk factors of MCI in the elderly in the community.Hypertension alone or high LDL-C (β=0.365, P=0.029, OR(95%CI)=1.44(1.04-2.00)) alone was risk factor for mild cognitive impairment in the elderly in the community.The risk of mild cognitive impairment in the elderly with hypertension and high LDL-C was 2.00 times higher than that in the healthy elderly (β=0.696, P<0.05, OR(95%CI)=2.00(1.36-2.97)). \u0000 \u0000 \u0000Conclusion \u0000Mild cognitive impairment in the elderly is closely related to hypertension and elevated LDL-C levels.Multiple vascular risk factors can further increase the risk of cognitive impairment. \u0000 \u0000 \u0000Key words: \u0000Cognitive impairment; Vascular risk factors; Hypertension; Elderly","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"28 1","pages":"865-869"},"PeriodicalIF":0.0,"publicationDate":"2019-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45541473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-10-20DOI: 10.3760/CMA.J.ISSN.1674-6554.2019.10.015
Yingchao Song, L. Hu, M. Liang
Objective To explore the effectiveness of different multiple comparisons correction methods by comparing the detection rate and false positive rate of brain activation analysis using functional magnetic resonance imaging (fMRI) data. Methods On the basis of task-based fMRI dataset (including low-intensity and high-intensity stimuli condition, n=20) and resting-state fMRI dataset(n=32), brain activation results were corrected by multiple comparsion correction methods in SPM and SnPM13 software, and the activation detection rate and false positive rate were compared with different correction methods. Results Voxel-or peak-based correction methods had relatively low false positive rate.When P<0.05 after correction, the proportion of the subjects with false-positive were 0.19 and 0.16, and the number of false-positive voxels were 404 and 2 448, respectively.But the two methods had low detection rate, which were more suitable for detecting strong activation.While cluster-based correction methods had relative high detection rate and high false positive rate.When P<0.05 after correction, the proportion of the subjects with false-positive were 0.34 and 0.38, and the number of false-positive voxels were 7 870 and 8 320, respectively.And thus they were more suitable for detecting weak activation. Group-level analysis could effectively reduce false positive rate. Conclusion In practice, researchers should choose a suitable correction method based on their specific research objectives and data to achieve a balance between the detection rate and false positive rate. Key words: fMRI; Brain activation; Multiple comparisons correction; False positive rate; Detection rate
{"title":"The validity of different multiple comparison correction methods in the analysis of brain function image data","authors":"Yingchao Song, L. Hu, M. Liang","doi":"10.3760/CMA.J.ISSN.1674-6554.2019.10.015","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-6554.2019.10.015","url":null,"abstract":"Objective \u0000To explore the effectiveness of different multiple comparisons correction methods by comparing the detection rate and false positive rate of brain activation analysis using functional magnetic resonance imaging (fMRI) data. \u0000 \u0000 \u0000Methods \u0000On the basis of task-based fMRI dataset (including low-intensity and high-intensity stimuli condition, n=20) and resting-state fMRI dataset(n=32), brain activation results were corrected by multiple comparsion correction methods in SPM and SnPM13 software, and the activation detection rate and false positive rate were compared with different correction methods. \u0000 \u0000 \u0000Results \u0000Voxel-or peak-based correction methods had relatively low false positive rate.When P<0.05 after correction, the proportion of the subjects with false-positive were 0.19 and 0.16, and the number of false-positive voxels were 404 and 2 448, respectively.But the two methods had low detection rate, which were more suitable for detecting strong activation.While cluster-based correction methods had relative high detection rate and high false positive rate.When P<0.05 after correction, the proportion of the subjects with false-positive were 0.34 and 0.38, and the number of false-positive voxels were 7 870 and 8 320, respectively.And thus they were more suitable for detecting weak activation. Group-level analysis could effectively reduce false positive rate. \u0000 \u0000 \u0000Conclusion \u0000In practice, researchers should choose a suitable correction method based on their specific research objectives and data to achieve a balance between the detection rate and false positive rate. \u0000 \u0000 \u0000Key words: \u0000fMRI; Brain activation; Multiple comparisons correction; False positive rate; Detection rate","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"28 1","pages":"941-946"},"PeriodicalIF":0.0,"publicationDate":"2019-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45181069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-10-20DOI: 10.3760/CMA.J.ISSN.1674-6554.2019.10.014
Li Jie, Qu Guangbo, Qin Qirong, Chen Jian, Z. Yuanyuan, Sun Ye-huan
Objective To explore the association between resilience and cognitive impairment in the elderly. Methods A face-to-face questionnaire survey was conducted among 6 524 elderly people aged 60 and over in Anhui Province by cluster sampling. The survey included general demographic characteristics, resilience and cognitive function. Statistical methods such as t-test, chi-square test, binary Logistic regression were used for data analysis. Results The incidence of cognitive impairment in the elderly was 13.6%(886/6 524). The score of resilience in the elderly with normal cognitive function was (64.89±11.96), while it was (56.10±11.12) in the elderly with impaired cognitive function and the difference was statistically significant (t=20.511, P<0.001). Logistic regression analysis showed that there was a statistical correlation between resilience and cognitive impairment in the elderly (OR=0.936, 95%CI: 0.930~0.943). After adjusting for depression, gender, age and other related factors, there was still a statistical correlation between resilience and cognitive impairment in the elderly (OR=0.963, 95%CI: 0.955~0.971). Conclusions Resilience is related to cognitive impairment in the elderly, and higher resilience is the protective factor for cognitive impairment. Key words: Resilience; Cognitive impairment; The elderly; Depression
{"title":"Association between resilience and cognitive impairment in the elderly","authors":"Li Jie, Qu Guangbo, Qin Qirong, Chen Jian, Z. Yuanyuan, Sun Ye-huan","doi":"10.3760/CMA.J.ISSN.1674-6554.2019.10.014","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-6554.2019.10.014","url":null,"abstract":"Objective \u0000To explore the association between resilience and cognitive impairment in the elderly. \u0000 \u0000 \u0000Methods \u0000A face-to-face questionnaire survey was conducted among 6 524 elderly people aged 60 and over in Anhui Province by cluster sampling. The survey included general demographic characteristics, resilience and cognitive function. Statistical methods such as t-test, chi-square test, binary Logistic regression were used for data analysis. \u0000 \u0000 \u0000Results \u0000The incidence of cognitive impairment in the elderly was 13.6%(886/6 524). The score of resilience in the elderly with normal cognitive function was (64.89±11.96), while it was (56.10±11.12) in the elderly with impaired cognitive function and the difference was statistically significant (t=20.511, P<0.001). Logistic regression analysis showed that there was a statistical correlation between resilience and cognitive impairment in the elderly (OR=0.936, 95%CI: 0.930~0.943). After adjusting for depression, gender, age and other related factors, there was still a statistical correlation between resilience and cognitive impairment in the elderly (OR=0.963, 95%CI: 0.955~0.971). \u0000 \u0000 \u0000Conclusions \u0000Resilience is related to cognitive impairment in the elderly, and higher resilience is the protective factor for cognitive impairment. \u0000 \u0000 \u0000Key words: \u0000Resilience; Cognitive impairment; The elderly; Depression","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"28 1","pages":"935-940"},"PeriodicalIF":0.0,"publicationDate":"2019-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47931595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-10-20DOI: 10.3760/CMA.J.ISSN.1674-6554.2019.10.008
Yurong Zhang, Ruizhong Wang, Yang Zhao, Li Wang, Junjun Mao, Fei Gao
Objective To investigate the effect of Lactobacillus casei on depressive behavior and the expression of NR1, NR2A receptor in postpartum depression rats induced by maternal separation. Methods Twenty-four Sprague-Dawley female rats were randomly divided into control group(CON group) (n=8), postpartum depression group(PPD group) (n=8), postpartum depression with lactobacillus casei group(PPD+ Lactobacillus casei group) (n=8). Rats of the control group were given no interventions.Rats in PPD group and PPD+ Lactobacillus casei group were given maternal separation to establish depression model.And then the rats in PPD+ Lactobacillus casei group were treated with Lactobacillus casei(8×108CFU/(kg·d)) for 4 weeks after 14 days of maternal separation.The forced swimming test (FST) was employed to detect the depressive behaviors.Lactobacillus, Bifidobacterium, Enterococcus faecalis and Escherichia coli in cecum of rats and the expression of NR1 and NR2A mRNA in hippocampus of rats were detected by real-time fluorescence quantitative PCR. Results Compared with CON group ((157.50±8.13) s), the immobility time of PPD group((200.00±10.35) s) was significantly longer (t=-3.23, P<0.05). Compared with PPD group, the immobility time of PPD+ Lactobacillus casei group ((153.25±7.41) s) was significantly shortened (t=3.67, P<0.05), and the depressive behavior was improved.Compared with CON group, the mRNA expression of Lactobacillus ((1.47±0.08), t=-5.87, P<0.01), Enterococcus faecalis ((1.23±0.08), t=-2.85, P<0.05) and Escherichia coli( (1.33±0.07), t=-4.96, P<0.01) in caecum were significantly increased in PPD group, while that of Bifidobacterium decreased significantly((0.65±0.07), t=5.18, P<0.01). Compared with PPD group, the mRNA expression of Lactobacillus( (1.05±0.05), t=3.67, P<0.01), Enterococcus faecalis ((0.97±0.05), t=2.74, P<0.05) and Escherichia coli ((1.06±0.05), t=3.31, P<0.01) were significantly decreased in PPD+ Lactobacillus casei group, while that of Bifidobacterium increased significantly ((0.98±0.04), t=-4.26, P<0.01). Compared with CON group, the mRNA expression of NR1 receptor ((0.57±0.04), t=9.65, P<0.01) and NR2A receptor ((0.60±0.05), t=8.64, P<0.05) in hippocampus of rats in PPD group were significantly decreased.Compared with PPD group, the expression of NR1 receptor ((1.01±0.05), t=-5.39, P<0.01) and NR2A receptor ((0.98±0.07), t=-3.91, P<0.05) in hippocampus were increased significantly in PPD+ Lactobacillus casei group. Conclusion Lactobacillus casei can improve the depressive behavior of postpartum depression in rats, and improve the intestinal flora, which affect the expression of NR1 and NR2A in hippocampus. Key words: Postpartum depression; Hippocampus; Intestinal flora; Lactobacillus casei; NR1 receptor; NR2A receptor; Rat
{"title":"Effect of Lactobacillus casei on the depressive behavior and the expression of NR1 and NR2A receptors in hippocampus of rats with postpartum depression induced by maternal separation","authors":"Yurong Zhang, Ruizhong Wang, Yang Zhao, Li Wang, Junjun Mao, Fei Gao","doi":"10.3760/CMA.J.ISSN.1674-6554.2019.10.008","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-6554.2019.10.008","url":null,"abstract":"Objective \u0000To investigate the effect of Lactobacillus casei on depressive behavior and the expression of NR1, NR2A receptor in postpartum depression rats induced by maternal separation. \u0000 \u0000 \u0000Methods \u0000Twenty-four Sprague-Dawley female rats were randomly divided into control group(CON group) (n=8), postpartum depression group(PPD group) (n=8), postpartum depression with lactobacillus casei group(PPD+ Lactobacillus casei group) (n=8). Rats of the control group were given no interventions.Rats in PPD group and PPD+ Lactobacillus casei group were given maternal separation to establish depression model.And then the rats in PPD+ Lactobacillus casei group were treated with Lactobacillus casei(8×108CFU/(kg·d)) for 4 weeks after 14 days of maternal separation.The forced swimming test (FST) was employed to detect the depressive behaviors.Lactobacillus, Bifidobacterium, Enterococcus faecalis and Escherichia coli in cecum of rats and the expression of NR1 and NR2A mRNA in hippocampus of rats were detected by real-time fluorescence quantitative PCR. \u0000 \u0000 \u0000Results \u0000Compared with CON group ((157.50±8.13) s), the immobility time of PPD group((200.00±10.35) s) was significantly longer (t=-3.23, P<0.05). Compared with PPD group, the immobility time of PPD+ Lactobacillus casei group ((153.25±7.41) s) was significantly shortened (t=3.67, P<0.05), and the depressive behavior was improved.Compared with CON group, the mRNA expression of Lactobacillus ((1.47±0.08), t=-5.87, P<0.01), Enterococcus faecalis ((1.23±0.08), t=-2.85, P<0.05) and Escherichia coli( (1.33±0.07), t=-4.96, P<0.01) in caecum were significantly increased in PPD group, while that of Bifidobacterium decreased significantly((0.65±0.07), t=5.18, P<0.01). Compared with PPD group, the mRNA expression of Lactobacillus( (1.05±0.05), t=3.67, P<0.01), Enterococcus faecalis ((0.97±0.05), t=2.74, P<0.05) and Escherichia coli ((1.06±0.05), t=3.31, P<0.01) were significantly decreased in PPD+ Lactobacillus casei group, while that of Bifidobacterium increased significantly ((0.98±0.04), t=-4.26, P<0.01). Compared with CON group, the mRNA expression of NR1 receptor ((0.57±0.04), t=9.65, P<0.01) and NR2A receptor ((0.60±0.05), t=8.64, P<0.05) in hippocampus of rats in PPD group were significantly decreased.Compared with PPD group, the expression of NR1 receptor ((1.01±0.05), t=-5.39, P<0.01) and NR2A receptor ((0.98±0.07), t=-3.91, P<0.05) in hippocampus were increased significantly in PPD+ Lactobacillus casei group. \u0000 \u0000 \u0000Conclusion \u0000Lactobacillus casei can improve the depressive behavior of postpartum depression in rats, and improve the intestinal flora, which affect the expression of NR1 and NR2A in hippocampus. \u0000 \u0000 \u0000Key words: \u0000Postpartum depression; Hippocampus; Intestinal flora; Lactobacillus casei; NR1 receptor; NR2A receptor; Rat","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"28 1","pages":"903-908"},"PeriodicalIF":0.0,"publicationDate":"2019-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46969701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-10-20DOI: 10.3760/CMA.J.ISSN.1674-6554.2019.10.012
Lilan Chen, Yan Wang, Shaobei Xiao
Objective To explore the mediating role of intelligence in the relationship between information processing speed and numerical magnitude processing of hearing-impaired children. Methods A survey was conducted among 249 hearing-impaired children by using tests of Choice Reaction Time, Numerosity Comparison, and Raven's Progressive Matrices(simplified version). Results (1)The accurate rate of information processing speed(0.89±0.18)of hearing-impaired children was positively correlated with that of numerical magnitude processing(0.65±0.15)and intelligence(11.83±10.34)(r=0.165, 0.263, both P<0.01). The reaction time of information processing speed was negatively correlated with those of numerical magnitude processing and intelligence(r=-0.164, -0.197, both P<0.05). And there was significant positive correlation between intelligence and numerical magnitude processing (accurate rate and reaction time ) (r=0.269, 0.140, both P<0.05). (2)The accurate rate of information processing speed significantly predicted that of numerical magnitude processing in hearing-impaired children(β=0.17, t=2.64, both P<0.01). The reaction time of information processing speed significantly predicted that of numerical magnitude processing in hearing-impaired children(β=-0.16, t=-2.61, both P<0.05). And intelligence played a complete mediating role in this relationship and the moderating effect were 36.71% and 31.25%. Conclusion Information processing speed has indirect effects on numerical magnitude processing through intelligence in hearing-impaired children. Key words: Hearing-impaired children; Information processing speed; Numerical magnitude processing; Intelligence
{"title":"The mediating effect of intelligence between the information processing speed and numerical magnitude in hearing-impaired children","authors":"Lilan Chen, Yan Wang, Shaobei Xiao","doi":"10.3760/CMA.J.ISSN.1674-6554.2019.10.012","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-6554.2019.10.012","url":null,"abstract":"Objective \u0000To explore the mediating role of intelligence in the relationship between information processing speed and numerical magnitude processing of hearing-impaired children. \u0000 \u0000 \u0000Methods \u0000A survey was conducted among 249 hearing-impaired children by using tests of Choice Reaction Time, Numerosity Comparison, and Raven's Progressive Matrices(simplified version). \u0000 \u0000 \u0000Results \u0000(1)The accurate rate of information processing speed(0.89±0.18)of hearing-impaired children was positively correlated with that of numerical magnitude processing(0.65±0.15)and intelligence(11.83±10.34)(r=0.165, 0.263, both P<0.01). The reaction time of information processing speed was negatively correlated with those of numerical magnitude processing and intelligence(r=-0.164, -0.197, both P<0.05). And there was significant positive correlation between intelligence and numerical magnitude processing (accurate rate and reaction time ) (r=0.269, 0.140, both P<0.05). (2)The accurate rate of information processing speed significantly predicted that of numerical magnitude processing in hearing-impaired children(β=0.17, t=2.64, both P<0.01). The reaction time of information processing speed significantly predicted that of numerical magnitude processing in hearing-impaired children(β=-0.16, t=-2.61, both P<0.05). And intelligence played a complete mediating role in this relationship and the moderating effect were 36.71% and 31.25%. \u0000 \u0000 \u0000Conclusion \u0000Information processing speed has indirect effects on numerical magnitude processing through intelligence in hearing-impaired children. \u0000 \u0000 \u0000Key words: \u0000Hearing-impaired children; Information processing speed; Numerical magnitude processing; Intelligence","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"28 1","pages":"925-929"},"PeriodicalIF":0.0,"publicationDate":"2019-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41638160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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