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Correlation of empathy with cognitive function in patients with cerebral small vessel disease 脑血管病患者共情与认知功能的关系
Pub Date : 2020-03-20 DOI: 10.3760/CMA.J.CN371468-20190930-00702
Chen Chen, Xiaojing Wang, Shanshan Cao, Jun Zhang, Q. Wei, Lei Zhang, Kai Wang
Objective To explore the empathy of patients with cerebral small vessel disease (CSVD) and its relationship with cognitive functions. Methods A total of 35 patients with CSVD and 26 normal controls with matching gender, age and education were enrolled.The Chinese version of the interpersonal reactivity index (IRI-C) and the multifaceted empathy test(MET) were used to assess the empathy of the participants.The montreal cognitive assessment scale (MoCA), the Hamilton anxiety scale(HAMA), and the Hamilton depression scale (HAMD) were applied to assess participants' overall cognitive function and emotional state.SPSS 19.0 software was used to analyze the differences between the CSVD group and the control group, while the influencing factors of empathy were studied by Pearson correlation analysis. Results The total scores of IRI, perspective taking(PT), fantasy(FS) and empathy concern(EC) of CSVD patients ((37.25±11.71), (6.94±4.35), (9.45±4.68) and (16.40±4.34)) were lower than those of the control group ((50.61±11.07), (11.84±3.90), (13.23±5.01), (19.69±3.03)), and the differences were statistically significant (IRI score: t=4.506, P 0.05). The MET-C results showed that there was a difference in the correct number of empathic emotion recognition between the two groups(CVSD group: (25.08±6.77), control group: (32.30±3.42), t=4.978, P 0.05). Pearson correlation analysis showed that the total score of IRI and PT in the CSVD group were positively correlated with education level (r=0.374, 0.471, both P<0.05). PT was positively correlated with MoCA score (r=0.458, P=0.006). PD was positively correlated with HAMA score and HAMD score (r=0.521, 0.541, both P<0.05). The correct number of emotion recognition was positively correlated with education level (r=0.600, P<0.001) and MoCA score (r=0.665, P<0.001), and negatively correlated with HAMA score(r=-0.445, P<0.05) and HAMD score (r=-0.421, P<0.05). Conclusion The empathy of patients with CSVD is lower than that of the normal group, and it is manifested as a decline in cognitive empathy, which is positively related to the overall cognitive function. Key words: Cerebral small vessel disease; Empathy; Cognitive function
目的探讨脑血管病(CSVD)患者共情状态及其与认知功能的关系。方法选取35例CSVD患者和26例性别、年龄、文化程度相匹配的正常对照。采用中国版的人际反应指数(IRI-C)和多面共情测验(MET)来评估被试的共情能力。采用蒙特利尔认知评估量表(MoCA)、汉密尔顿焦虑量表(HAMA)和汉密尔顿抑郁量表(HAMD)评估被试的整体认知功能和情绪状态。采用SPSS 19.0软件分析CSVD组与对照组的差异,采用Pearson相关分析研究共情的影响因素。结果CSVD患者IRI、观点采取(PT)、幻想(FS)、共情关注(EC)总分((37.25±11.71)、(6.94±4.35)、(9.45±4.68)、(16.40±4.34))低于对照组((50.61±11.07)、(11.84±3.90)、(13.23±5.01)、(19.69±3.03)),差异有统计学意义(IRI评分:t=4.506, P 0.05)。MET-C结果显示,两组共情情绪识别正确率差异有统计学意义(CVSD组:(25.08±6.77),对照组:(32.30±3.42),t=4.978, P < 0.05)。Pearson相关分析显示,CSVD组IRI、PT总分与文化程度呈正相关(r=0.374、0.471,P均<0.05)。PT与MoCA评分呈正相关(r=0.458, P=0.006)。PD与HAMA评分、HAMD评分呈正相关(r=0.521、0.541,P均<0.05)。情绪识别正确率与受教育程度(r=0.600, P<0.001)、MoCA评分(r=0.665, P<0.001)呈正相关,与HAMA评分(r=-0.445, P<0.05)、HAMD评分(r=-0.421, P<0.05)呈负相关。结论CSVD患者共情能力低于正常组,表现为认知共情能力下降,与整体认知功能呈正相关。关键词:脑血管病;同理心;认知功能
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引用次数: 0
The qualitative study of disease cognition, treatment compliance and community services evaluation of community patients with schizophrenia, family members and disease control personnels 社区精神分裂症患者、家属及疾病控制人员疾病认知、治疗依从性及社区服务评价的定性研究
Pub Date : 2020-03-20 DOI: 10.3760/CMA.J.CN371468-20200117-00995
Zhen-song Gao, Zehua Chen, Lijian Xu, Sai-Sai Guo, Shengjiao Zhang, Wenhua Zheng, Minji Wu
Objective To investigate the evaluation of disease perception, treatment compliance and community follow-up services of community schizophrenia patients, family members and personnel in Shantou City, and to provide a reference basis for improving the quality of management treatment. Methods With the method of stratified sampling qualitative research, a community sample of 17 198 patients with schizophrenia in seven districts or county in Shantou City were sampled from February to August 2019, with 2 towns being drawn from each district or county, and 10 patients, 10 family members and 3 personnel were selected in each town. The evaluation of disease perception, treatment compliance and community follow-up services were investigated and analyzed. Respondents were eventually included in 137 patients, 138 family members and 41 personnel.The interviewees were conducted with semi-structured interviews, the data were collected according to traditional methods, and the descriptive statistical analysis was carried out with SPSS 12.0. Results (1)34.3% of patients and 32.6% of the family members were not fully aware of the disease.22.6% of the patients and 23.2% of the family members had a sense of ill shame. (2)26.3% of patients did not comply with treatment, 29.9% of patients had not insight, 53.3% of patients and 24.6% of family members on the side effects of drugs and addiction understood improperly, and, 35.0% of patients and 13.0% of the family had a misunderstanding of illness and using drugs. (3)29.2% of patients and 31.2% of their families were tired of taking long-term medication, 24.8% of patients and 21.0% of their families felt socially isolated, and, 17.5% felt unsupported and 18.8% of their families admitted that they did not care enough about patients. (4)31.4% of patients did not actively receive follow-up services, 37.2% of patients and 20.3% of family members did not cooperate with follow-up doctors, and, 21.2% of patients and 10.1% of family members were not satisfied with follow-up services. (5)The personnel of psychiatric care could basically grasp the conditions of patients in the jurisdiction and carried out follow-up services on a regular basis (90.2%), master emergency disposal methods (92.7%), and have carried out training (97.6%). However, the psychiatric practice of the personnel were lower than (58.5%) and most lying part-time (78.0%), the average length of service was 5.7±1.4 years. The personnel satisfaction with the community follow-up service was higher (95.1%), but most of them thought that the psychiatric care was more difficult (36.6%), and were dissatisfied with the multi-functional staff to undertake a number of public services (31.7%). Conclusion The management treatment project of mental disorders services in Shantou City show initial results.The patients were satisfied with the community follow-up service, but the patients and their families still have low level of cognition, poor compliance, obv
目的了解汕头市社区精神分裂症患者、家属及工作人员的疾病认知、治疗依从性及社区随访服务情况,为提高管理治疗质量提供参考依据。方法采用分层抽样定性研究方法,于2019年2月至8月抽取汕头市7个区县的17198名精神分裂症患者为社区样本,每个区县抽取2个乡镇,每个乡镇抽取10名患者、10名家属和3名工作人员。对疾病认知、治疗依从性和社区随访服务的评价进行了调查和分析。受访者最终包括137名患者、138名家庭成员和41名工作人员。受访者采用半结构化访谈,数据按传统方法收集,采用SPSS 12.0进行描述性统计分析。结果(1)34.3%的患者和32.6%的家庭成员对该疾病没有充分的认识,22.6%的患者和23.2%的家庭成员有恶感。(2) 26.3%的患者不遵守治疗,29.9%的患者没有洞察力,53.3%的患者和24.6%的家庭成员对药物的副作用和成瘾理解不当,35.0%的患者和13.0%的家庭对疾病和用药有误解。(3) 29.2%的患者和31.2%的家人厌倦了长期服药,24.8%的患者和21.0%的家人感到社交孤立,17.5%的患者和18.8%的家人承认他们对患者不够关心。(4) 31.4%的患者没有积极接受随访服务,37.2%的患者和20.3%的家属不配合随访医生,21.2%的患者和10.1%的家属对随访服务不满意。(5) 精神科护理人员基本能够掌握辖区内患者的病情,定期开展随访服务(90.2%),掌握应急处置方法(92.7%),并进行过培训(97.6%),但精神科执业人员低于(58.5%),大部分为兼职(78.0%),平均服务年限为5.7±1.4年。工作人员对社区随访服务的满意度较高(95.1%),但大多数人认为精神病护理难度较大(36.6%),对多功能工作人员承担多项公共服务不满意(31.7%)。患者对社区随访服务满意,但患者及其家属认知水平仍较低,依从性差,负面情绪明显,对药物治疗有顾虑。要加强人员专业化,对患者及其家属进行早期心理健康教育和理性情绪行为训练。关键词:精神分裂症;疾病认知;治疗依从性;社区管理;定性研究
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引用次数: 0
Capacity of cognitive control in patients with cerebral small vessel disease 脑小血管病患者的认知控制能力
Pub Date : 2020-03-20 DOI: 10.3760/CMA.J.CN371468-20190927-00695
Zhiqi Wang, Jun Zhang, Q. Wei, Shanshan Cao, Wen Pan, Kai Wang
Objective To evaluate the capacity of cognitive control(CCC) in patients with cerebral small vessel disease(CSVD) and explore the relationship between CCC and cognitive function in CSVD, and to assess the predict value of CCC on the occurrence of CSVD. Methods Twenty-two patients with CSVD and twenty-three healthy controls were enrolled.All of them completed the majority function task-masked (MFT-M) and a set of neuropsychological tests.Neuropsychological test was performed by Montreal cognitive assessment (MoCA), verbal fluency test (VFT), Chinese auditory learning test (CAVLT), symbol digit modalities test (SDMT), digital span (DS), Stroop color word test (SCWT), color trail test (CTT) and Modified Boston naming test (Modified BNT). The predict value of CCC for the occurrence of CSVD was assessed with logistic regression analysis. Results CCC of patients with CSVD was lower than that of healthy control ((2.97±0.72)bps vs (3.53±0.62)bps, t=-2.704, P=0.01). Between patients with CSVD and healthy control, there were significant differences in MoCA ((22.24±4.58 vs (24.86±2.42), t=-2.334, P=0.026), VFT-animal (12(6) vs 15(6), Z=-2.965, P=0.003), VFT-vegetables and fruits ((13.79±3.81) vs (18.27±4.13), t=-3.592, P=0.001), CAVLT-immediate ((7.45±2.18) vs (9.11±2.08), t=-2.502, P=0.017), CAVLT-short term delay ((7.20±3.32) vs (10.76±3.08), t=-3.564, P=0.001), CAVLT-long term delay ((7.30±3.16) vs (10.29±3.18), t=-3.012, P=0.005), SDMT ((15.95±5.49) vs (23.41±12.73), t=-2.513, P=0.018), CTT-A (85.17(42.60) vs 55.50(52.65), Z=-2.965, P=0.003), CTT-B ((200.69±71.35) vs (132.44±53.66), t=3.556, P=0.001), and CTT-B-A ((104.13±53.31) vs (65.20±35.98), t=2.819, P=0.007). But there was no significant difference in VFT-word begin with Chinese character"water"((3.68±2.63) vs (5.44±2.71), t=-1.940, P=0.061), CAVLT-recognition (14(3) vs 14(4), Z=-0.524, P=0.601), DS-forward (7.0(3.0) vs 5.5(2.0), Z=-0.152, P=0.880), DS-backward (4(1) vs 4(2), Z=-1.044, P=0.297), SCWT ((9.50±9.28) vs (5.94±10.47), t=1.123, P=0.268), Modified BNT (14.0(3.0) vs 13.5(3.0), Z=-0.727, P=0.467) between CSVD patients and healthy controls.In patients with CSVD, CCC was positively correlated with scores of MoCA (r=0.551, P=0.010) and also with DS-forward (r=0.532, P=0.013) and SCWT (r=-0.487, P=0.040). Logistic regression analysis showed that CCC was an important variable in predicting the possibility of CSVD (B=-1.318, P=0.019, OR=0.268, 95%CI (0.089-0.808)). Conclusion Compared with the healthy control, CCC in patients with CSVD decreases significantly and CCC is related to the cognitive impairment.CCC can predict the possibility of CSVD. Key words: Cognitive control capacity; Cerebral small vessel disease; Cognitive function
目的评价脑血管病(CSVD)患者的认知控制能力,探讨认知控制与认知功能的关系,评价认知控制对脑血管病发生的预测价值。方法选取22例CSVD患者和23例健康对照者。所有受试者均完成了多数功能任务屏蔽(MFT-M)和一组神经心理测试。神经心理测试采用蒙特利尔认知测验(MoCA)、语言流畅性测验(VFT)、汉语听觉学习测验(CAVLT)、符号数字模态测验(SDMT)、数字广度测验(DS)、Stroop颜色词测验(SCWT)、颜色轨迹测验(CTT)和改良波士顿命名测验(Modified Boston naming test)进行。采用logistic回归分析评估CCC对CSVD发生的预测价值。结果CSVD患者的CCC低于健康对照组((2.97±0.72)bps vs(3.53±0.62)bps, t=-2.704, P=0.01)。在CSVD患者和健康对照组之间,MoCA(22.24±4.58 vs(24.86±2.42),t=-2.334, P=0.026)、vft -动物(12(6)vs 15(6), Z=-2.965, P=0.003)、vft -蔬菜水果((13.79±3.81)vs(18.27±4.13),t=-3.592, P=0.001)、cavlt -即时((7.45±2.18)vs(9.11±2.08),t=-2.502, P=0.017)、cavlt -短期延迟((7.20±3.32)vs(10.76±3.08),t=-3.564, P=0.001)、cavlt -长期延迟((7.30±3.16)vs(10.29±3.18),t=-3.012, P=0.005)、cavlt -长期延迟((7.30±3.16)vs(10.29±3.18),t=-3.012, P=0.005。SDMT((15.95±5.49)和(23.41±12.73),t = -2.513, P = 0.018), CTT-A(85.17(42.60)和55.50 (52.65),Z = -2.965, P = 0.003), CTT-B((200.69±71.35)和(132.44±53.66),t = 3.556, P = 0.001),和CTT-B-A((104.13±53.31)和(65.20±35.98),t = 2.819, P = 0.007)。但在以“水”字为首字的vft((3.68±2.63)vs(5.44±2.71),t=-1.940, P=0.061)、cavlt识别(14(3)vs 14(4), Z=-0.524, P=0.601)、DS-forward (7.0(3.0) vs 5.5(2.0), Z=-0.152, P=0.880)、DS-backward (4(1) vs 4(2), Z=-1.044, P=0.297)、SCWT((9.50±9.28)vs(5.94±10.47),t=1.123, P=0.268)、改良BNT (14.0(3.0) vs 13.5(3.0), Z=-0.727, P=0.467)方面,CSVD患者与健康对照组无显著差异。CSVD患者CCC与MoCA评分呈正相关(r=0.551, P=0.010),与DS-forward评分呈正相关(r=0.532, P=0.013),与SCWT评分呈正相关(r=-0.487, P=0.040)。Logistic回归分析显示,CCC是预测CSVD发生可能性的重要变量(B=-1.318, P=0.019, OR=0.268, 95%CI(0.089 ~ 0.808))。结论与健康对照组相比,CSVD患者的CCC明显降低,且与认知功能障碍有关。CCC可以预测CSVD发生的可能性。关键词:认知控制能力;脑血管病;认知功能
{"title":"Capacity of cognitive control in patients with cerebral small vessel disease","authors":"Zhiqi Wang, Jun Zhang, Q. Wei, Shanshan Cao, Wen Pan, Kai Wang","doi":"10.3760/CMA.J.CN371468-20190927-00695","DOIUrl":"https://doi.org/10.3760/CMA.J.CN371468-20190927-00695","url":null,"abstract":"Objective \u0000To evaluate the capacity of cognitive control(CCC) in patients with cerebral small vessel disease(CSVD) and explore the relationship between CCC and cognitive function in CSVD, and to assess the predict value of CCC on the occurrence of CSVD. \u0000 \u0000 \u0000Methods \u0000Twenty-two patients with CSVD and twenty-three healthy controls were enrolled.All of them completed the majority function task-masked (MFT-M) and a set of neuropsychological tests.Neuropsychological test was performed by Montreal cognitive assessment (MoCA), verbal fluency test (VFT), Chinese auditory learning test (CAVLT), symbol digit modalities test (SDMT), digital span (DS), Stroop color word test (SCWT), color trail test (CTT) and Modified Boston naming test (Modified BNT). The predict value of CCC for the occurrence of CSVD was assessed with logistic regression analysis. \u0000 \u0000 \u0000Results \u0000CCC of patients with CSVD was lower than that of healthy control ((2.97±0.72)bps vs (3.53±0.62)bps, t=-2.704, P=0.01). Between patients with CSVD and healthy control, there were significant differences in MoCA ((22.24±4.58 vs (24.86±2.42), t=-2.334, P=0.026), VFT-animal (12(6) vs 15(6), Z=-2.965, P=0.003), VFT-vegetables and fruits ((13.79±3.81) vs (18.27±4.13), t=-3.592, P=0.001), CAVLT-immediate ((7.45±2.18) vs (9.11±2.08), t=-2.502, P=0.017), CAVLT-short term delay ((7.20±3.32) vs (10.76±3.08), t=-3.564, P=0.001), CAVLT-long term delay ((7.30±3.16) vs (10.29±3.18), t=-3.012, P=0.005), SDMT ((15.95±5.49) vs (23.41±12.73), t=-2.513, P=0.018), CTT-A (85.17(42.60) vs 55.50(52.65), Z=-2.965, P=0.003), CTT-B ((200.69±71.35) vs (132.44±53.66), t=3.556, P=0.001), and CTT-B-A ((104.13±53.31) vs (65.20±35.98), t=2.819, P=0.007). But there was no significant difference in VFT-word begin with Chinese character\"water\"((3.68±2.63) vs (5.44±2.71), t=-1.940, P=0.061), CAVLT-recognition (14(3) vs 14(4), Z=-0.524, P=0.601), DS-forward (7.0(3.0) vs 5.5(2.0), Z=-0.152, P=0.880), DS-backward (4(1) vs 4(2), Z=-1.044, P=0.297), SCWT ((9.50±9.28) vs (5.94±10.47), t=1.123, P=0.268), Modified BNT (14.0(3.0) vs 13.5(3.0), Z=-0.727, P=0.467) between CSVD patients and healthy controls.In patients with CSVD, CCC was positively correlated with scores of MoCA (r=0.551, P=0.010) and also with DS-forward (r=0.532, P=0.013) and SCWT (r=-0.487, P=0.040). Logistic regression analysis showed that CCC was an important variable in predicting the possibility of CSVD (B=-1.318, P=0.019, OR=0.268, 95%CI (0.089-0.808)). \u0000 \u0000 \u0000Conclusion \u0000Compared with the healthy control, CCC in patients with CSVD decreases significantly and CCC is related to the cognitive impairment.CCC can predict the possibility of CSVD. \u0000 \u0000 \u0000Key words: \u0000Cognitive control capacity; Cerebral small vessel disease; Cognitive function","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"29 1","pages":"221-226"},"PeriodicalIF":0.0,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46392508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The relationship between the dark triad and guilt proneness: the mediating role of basic psychological needs satisfaction 黑暗三合会与内疚倾向的关系:基本心理需求满足的中介作用
Pub Date : 2020-03-20 DOI: 10.3760/CMA.J.CN371468-20190905-00603
Liping Shi, Xueli Zhu, Tingting Zhan, Jiejing Yu, Jingjing Gu, Dan Shi, Yaoguo Geng
Objective To explore the relationship between the dark triad, basic psychological needs satisfaction and guilty proneness. Methods Totally 595 college students were randomly selected from Zhengzhou University.They were tested with the dirty dozen(DD), the balanced measure of psychological needs scale(BMPN) and guilt-proneness-5(GP-5). SPSS 22.0 and AMOS 21.0 were used for data analysis, including descriptive analysis, correlation analysis and confirmatory factor analysis. Bootstrap measure was used for mediating effect test. Results (1)The correlation analysis showed that the dark triad (29(21, 37)), Machiavellianism (4(4, 8)) and psychopathy(5(4, 9)) were negatively correlated with guilty proneness (20(16, 23)), and the correlation coefficients were -0.10, -0.22 and -0.18 respectively(all P 0.01). The satisfaction of basic psychological needs (56(54, 60)) was positively correlated with guilty proneness (r=0.31, P<0.01). (2)The relationship between the dark triad and guilty proneness was partially mediated by basic psychological needs satisfaction, and the mediating effect accounted for 62.96%. Conclusion The dark triad influences guilty proneness through basic psychological needs satisfaction. Key words: The dark triad; Machiavellianism; Psychopathy; Guilty proneness; Basic psychological needs satisfaction
目的探讨黑暗三合会、基本心理需求满足与犯罪倾向的关系。方法随机抽取郑州大学595名在校大学生,采用脏打量表(DD)、心理需求量表(BMPN)和内疚倾向量表(GP-5)对其进行测试。采用SPSS 22.0和AMOS 21.0进行数据分析,包括描述性分析、相关性分析和验证性因素分析。采用Bootstrap方法进行中介效应测试。结果(1)相关分析表明,黑暗三合会(29(21,37))、马基雅维利主义(4(4,8))和精神病(5(4,9))与有罪倾向呈负相关(20(16,23)),相关系数为-0.10,基本心理需求满意度(56(54,60))与有罪倾向呈正相关(r=0.31,P<0.01),结论黑暗三合会通过基本心理需求满足影响犯罪倾向。关键词:黑暗三和弦;马基雅维利主义;精神病;有罪倾向;基本心理需求满足
{"title":"The relationship between the dark triad and guilt proneness: the mediating role of basic psychological needs satisfaction","authors":"Liping Shi, Xueli Zhu, Tingting Zhan, Jiejing Yu, Jingjing Gu, Dan Shi, Yaoguo Geng","doi":"10.3760/CMA.J.CN371468-20190905-00603","DOIUrl":"https://doi.org/10.3760/CMA.J.CN371468-20190905-00603","url":null,"abstract":"Objective \u0000To explore the relationship between the dark triad, basic psychological needs satisfaction and guilty proneness. \u0000 \u0000 \u0000Methods \u0000Totally 595 college students were randomly selected from Zhengzhou University.They were tested with the dirty dozen(DD), the balanced measure of psychological needs scale(BMPN) and guilt-proneness-5(GP-5). SPSS 22.0 and AMOS 21.0 were used for data analysis, including descriptive analysis, correlation analysis and confirmatory factor analysis. Bootstrap measure was used for mediating effect test. \u0000 \u0000 \u0000Results \u0000(1)The correlation analysis showed that the dark triad (29(21, 37)), Machiavellianism (4(4, 8)) and psychopathy(5(4, 9)) were negatively correlated with guilty proneness (20(16, 23)), and the correlation coefficients were -0.10, -0.22 and -0.18 respectively(all P 0.01). The satisfaction of basic psychological needs (56(54, 60)) was positively correlated with guilty proneness (r=0.31, P<0.01). (2)The relationship between the dark triad and guilty proneness was partially mediated by basic psychological needs satisfaction, and the mediating effect accounted for 62.96%. \u0000 \u0000 \u0000Conclusion \u0000The dark triad influences guilty proneness through basic psychological needs satisfaction. \u0000 \u0000 \u0000Key words: \u0000The dark triad; Machiavellianism; Psychopathy; Guilty proneness; Basic psychological needs satisfaction","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"29 1","pages":"262-265"},"PeriodicalIF":0.0,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49603546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Psychometric properties and applications of the system of quality of life instruments for cancer patients 癌症患者生活质量仪器系统的心理测量特性及其应用
Pub Date : 2020-03-20 DOI: 10.3760/CMA.J.CN371468-20190827-00557
C. Wan, Zheng Yang, Ting Wu, Jia-hong Luo, Qiong Meng, Gaofeng Li, Yingli Cun
Objective To present briefly introductions and evaluations on the constructs, psychometric properties (reliability, validity, reactivity etc.) and applications of the system of Quality of Life Instruments for Cancer Patients QLICP(V1.0) including 12 kinds of scales for patients with head and neck cancer, brain cancer, lung cancer, breast cancer, esophageal cancer, gastric cancer, colorectal cancer, liver cancer, cervical cancer, ovarian cancer, leukemia and lymphoma. Methods Based on our measuring data from relevant patients at hospitals, the constructs, characteristics and psychometrics of the system above were analyzed and presented. Internal consistency reliability for each domain and the overall scale was assessed using Cronbach's alpha coefficient, and test-retest reliability through calculating the Pearson correlation coefficient between the first and second assessments. The criterion-related validity was evaluated by correlating corresponding domains of two instruments. Responsiveness was assessed through comparing the mean difference between the pre-treatment and post-treatments with standardized response mean (SRM). The use agreements and literature reviews of this system were used to understand the applications of 12 kinds measurement scales. Results The quality of life scales for 12 kinds of cancer patients of the system QLICP(V1.0) have good construct( 5 domains, 11-15 facets), reliability, validity and a certain degree of responsiveness. The internal consistency reliability Cronbach's α coefficients for the overall scale of QLICP in different cancers was from 0.67 to 0.92, and the test-retest reliability (correlation coefficient) was from 0.61 to 0.99. The criterion-related validity (correlation coefficient) was for the overall scale of QLICP in different cancers was from 0.28 to 0.89, and the responsiveness SRM was from 0.25 to 1.28. And also they were widely used in clinical practice and relevant studies for the corresponding cancers. Conclusion The system QLICP(V1.0) is of outstanding characteristics with all psychometrics meeting requirements and better construct (clear hierarchical structure with items→ facets→ domains→ overall ), and can be used widely in clinical practice further. Key words: Quality of life; Cancer; Instrument system
目的简要介绍和评价癌症患者生活质量量表QLICP(V1.0)系统的结构、心理测量特性(信度、有效性、反应性等)及其应用,包括12种癌症、癌症、癌症、癌症、,结直肠癌癌症、癌症、癌症、卵巢癌症、白血病和淋巴瘤。方法根据医院相关患者的测量数据,分析并提出了该系统的结构、特点和心理测量方法。使用Cronbachα系数评估每个领域和整体量表的内部一致性可靠性,并通过计算第一次和第二次评估之间的Pearson相关系数来评估重测可靠性。通过关联两个工具的相应领域来评估标准相关的有效性。通过将治疗前和治疗后的平均差异与标准化反应平均值(SRM)进行比较来评估反应性。利用该系统的使用协议和文献综述,了解12种量表的应用情况。结果QLICP系统的12种癌症患者生活质量量表(V1.0)具有良好的结构(5个领域,11-15个方面)、可靠性、有效性和一定程度的反应性。不同癌症QLICP总体量表的内部一致性信度Cronbachα系数为0.67至0.92,重测信度(相关系数)为0.61至0.99。不同癌症QLICP总体量表的标准相关有效性(相关系数)为0.28至0.89,响应性SRM为0.25至1.28。它们也被广泛应用于临床实践和相应癌症的相关研究中。结论QLICP系统(V1.0)具有突出的特点,各项心理测量指标均满足要求,结构清晰(项目层次结构清晰)→ 刻面→ 域→ 总体上)并且可以在临床实践中进一步广泛使用。关键词:生活质量;癌症;仪表系统
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引用次数: 0
Association of endocannabinoid and its metabolic enzymes with severity in children with autism spectrum disorder 内源性大麻素及其代谢酶与自闭症谱系障碍儿童严重程度的关系
Pub Date : 2020-03-20 DOI: 10.3760/CMA.J.CN371468-20190905-00595
Dexin Li, Ling Li, M. Zou, Yu Liu, Shuang Xie, Caihong Sun
Objective To explore the relationship between endocannabinoid (eCB) and its metabolic enzymes and severity of autism spectrum disorder (ASD), and to provide a theoretical basis for the study of the etiology and pathogenesis of ASD. Methods A case-control study was conducted to collect 58 ASD children who underwent rehabilitation training at the Children's Developmental Behavior Research Center of Harbin Medical University and the provincial autism rehabilitation facility from December 2017 to December 2018 as the ASD group.According to the principle of gender and age 1∶1 matching, 58 normal children were selected as control group in Heilongjiang Province.Liquid chromatography-tandem mass spectrometry (LC-MS/MS) and real-time quantitative PCR (RT-qPCR) were used to detect eCB of ASD group and control group, including anandamide (AEA), 2-arachidonoylglycerol (2-AG), palmitoylethanolamide (PEA), oleoylethanolamide (OEA) and its metabolic enzymes: n-acylphosphatidylethanolamine-specific phospholipase D (NAPE-PLD), fatty acid amide hydrolase (FAAH), monoacylglycerol lipase (MAGL) and diacylglycerol lipase (DAGL) mRNA expression levels.Pearson correlation was used to analyze the level of eCB and ASD children's severity. Results The levels of AEA, OEA and PEA in ASD children ((10.10±2.6)nmol/L, (24.30±5.60)nmol/L, (15.92±2.28)nmol/L) were lower than those in the control group ((13.46±3.04)nmol/L, (27.85± 6.89)nmol/L, (17.87±2.67)nmol/L, t=-6.612, -3.99, -4.779, P 0.05). The level of PEA in the ASD group was negatively correlated with the total score of the autism behavior checklist (ABC) (r=-0.288, P<0.05). Conclusion There may be metabolic abnormalities in eCB and its metabolic enzymes in ASD children, and the level of eCB is related with the severity of ASD. Key words: Autism spectrum disorder; Endocannabinoid; Liquid chromatography-tandem mass spectrometry
目的探讨内源性大麻素(eCB)及其代谢酶与自闭症谱系障碍(ASD)严重程度的关系,为研究ASD的病因病机提供理论依据。方法采用病例对照研究方法,收集2017年12月至2018年12月在哈尔滨医科大学儿童发展行为研究中心和省级自闭症康复机构接受康复训练的58名自闭症谱系障碍儿童作为ASD组。根据性别和年龄1∶1匹配原则,选取黑龙江省58名正常儿童作为对照组,采用液相色谱-串联质谱(LC-MS/MS)和实时定量PCR(RT-qPCR)检测ASD组和对照组的eCB,油酰乙醇酰胺(OEA)及其代谢酶:n-酰基磷脂酰乙醇胺特异性磷脂酶D(NAPE-PLD)、脂肪酸酰胺水解酶(FAAH)、单酰基甘油脂肪酶(MAGL)和二酰基甘油脂酶(DAGL)mRNA表达水平。采用Pearson相关分析eCB水平与ASD儿童的严重程度。结果ASD患儿的AEA、OEA和PEA水平分别为(10.10±2.6)nmol/L、(24.30±5.60)nmol/L、(15.92±2.28)nmol/L,均低于对照组((13.46±3.04)nmol、(27.85±6.89)nmol/L、(17.87±2.67)nmol/L,t=-6.612、-3.99、-4.779,结论ASD患儿的eCB及其代谢酶可能存在代谢异常,eCB水平与ASD的严重程度有关。关键词:自闭症谱系障碍;内源性大麻素;液相色谱-串联质谱法
{"title":"Association of endocannabinoid and its metabolic enzymes with severity in children with autism spectrum disorder","authors":"Dexin Li, Ling Li, M. Zou, Yu Liu, Shuang Xie, Caihong Sun","doi":"10.3760/CMA.J.CN371468-20190905-00595","DOIUrl":"https://doi.org/10.3760/CMA.J.CN371468-20190905-00595","url":null,"abstract":"Objective \u0000To explore the relationship between endocannabinoid (eCB) and its metabolic enzymes and severity of autism spectrum disorder (ASD), and to provide a theoretical basis for the study of the etiology and pathogenesis of ASD. \u0000 \u0000 \u0000Methods \u0000A case-control study was conducted to collect 58 ASD children who underwent rehabilitation training at the Children's Developmental Behavior Research Center of Harbin Medical University and the provincial autism rehabilitation facility from December 2017 to December 2018 as the ASD group.According to the principle of gender and age 1∶1 matching, 58 normal children were selected as control group in Heilongjiang Province.Liquid chromatography-tandem mass spectrometry (LC-MS/MS) and real-time quantitative PCR (RT-qPCR) were used to detect eCB of ASD group and control group, including anandamide (AEA), 2-arachidonoylglycerol (2-AG), palmitoylethanolamide (PEA), oleoylethanolamide (OEA) and its metabolic enzymes: n-acylphosphatidylethanolamine-specific phospholipase D (NAPE-PLD), fatty acid amide hydrolase (FAAH), monoacylglycerol lipase (MAGL) and diacylglycerol lipase (DAGL) mRNA expression levels.Pearson correlation was used to analyze the level of eCB and ASD children's severity. \u0000 \u0000 \u0000Results \u0000The levels of AEA, OEA and PEA in ASD children ((10.10±2.6)nmol/L, (24.30±5.60)nmol/L, (15.92±2.28)nmol/L) were lower than those in the control group ((13.46±3.04)nmol/L, (27.85± 6.89)nmol/L, (17.87±2.67)nmol/L, t=-6.612, -3.99, -4.779, P 0.05). The level of PEA in the ASD group was negatively correlated with the total score of the autism behavior checklist (ABC) (r=-0.288, P<0.05). \u0000 \u0000 \u0000Conclusion \u0000There may be metabolic abnormalities in eCB and its metabolic enzymes in ASD children, and the level of eCB is related with the severity of ASD. \u0000 \u0000 \u0000Key words: \u0000Autism spectrum disorder; Endocannabinoid; Liquid chromatography-tandem mass spectrometry","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"29 1","pages":"245-249"},"PeriodicalIF":0.0,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41869520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correlation of total magnetic resonance imaging burden with homocysteine in patients with cerebral small vessel disease 脑小血管病患者总磁共振成像负荷与同型半胱氨酸的相关性
Pub Date : 2020-03-20 DOI: 10.3760/CMA.J.CN371468-20191216-00913
Y. Ji, Zhenjie Teng, Xiangyu Li, Xiaosha Li, Peiyuan Lyu
Objective To explore the relationship between total MRI burden and serum homocysteine (Hcy) in patients with cerebral small vessel disease(CSVD), and to provide clues for disease prevention and treatment. Methods A total of 370 inpatients with CSVD from the neurology department of hospital were consecutively enrolled from September 2016 to December 2018.The clinical data, including serum homocysteine(Hcy) levels were collected.Brain MRI data were collected, including the severity of white matter hyperintensities(WMH), lacune infarcts(LI), cerebral microbleeds(CMBs), and enlarged perivascular spaces(ePVS) to evaluate the total load of CSVD.SPSS21.0 was applied to analyze the association between total CSVD burden and Hcy. Results (1)Compared with the patients with lower Hcy levels, the higher Hcy group had heavier total burdens of CSVD(P<0.01). (2)According to the total MRI burden scores of CSVD, all patients were further divided into low burden group(106 cases) and moderate-high burden group(264 cases). Multivariate logistic regression analysis showed that Hcy(OR=1.026, 95%CI: 1.003-1.049, P=0.026) was risk factor for increasing CSVD burden and hyperhomocysteinemia was a stronger predictor for total MRI burdens of CSVD(OR=3.202, 95%CI: 1.947-5.268, P<0.001). Conclusion Serum Hcy can be an independent risk factor for the total MRI burdens of CSVD.This finding provides a promising clue for the prediction and clinical management of CSVD. Key words: Cerebral small vessel disease; Risk factor; Magnetic resonance imaging; Homocysteine
目的探讨脑血管病(CSVD)患者MRI总负荷与血清同型半胱氨酸(Hcy)的关系,为该病的防治提供依据。方法选取2016年9月至2018年12月我院神经内科住院CSVD患者370例。收集临床资料,包括血清同型半胱氨酸(Hcy)水平。收集脑MRI数据,包括脑白质高信号(WMH)、腔隙性梗死(LI)、脑微出血(CMBs)和血管周围间隙扩大(ePVS)的严重程度,评估CSVD总负荷,应用spss21.0分析CSVD总负荷与Hcy的相关性。结果(1)与Hcy水平较低的患者相比,Hcy水平较高的患者CSVD总负担更重(P<0.01)。(2)根据CSVD MRI总负荷评分,将所有患者进一步分为低负荷组(106例)和中高负荷组(264例)。多因素logistic回归分析显示,Hcy(OR=1.026, 95%CI: 1.003 ~ 1.049, P=0.026)是增加CSVD负荷的危险因素,高同型半胱氨酸血症是CSVD MRI总负荷的较强预测因子(OR=3.202, 95%CI: 1.947 ~ 5.268, P<0.001)。结论血清Hcy是心血管疾病MRI总负荷的独立危险因素。这一发现为心血管疾病的预测和临床治疗提供了有希望的线索。关键词:脑血管病;风险因素;磁共振成像;同型半胱氨酸
{"title":"Correlation of total magnetic resonance imaging burden with homocysteine in patients with cerebral small vessel disease","authors":"Y. Ji, Zhenjie Teng, Xiangyu Li, Xiaosha Li, Peiyuan Lyu","doi":"10.3760/CMA.J.CN371468-20191216-00913","DOIUrl":"https://doi.org/10.3760/CMA.J.CN371468-20191216-00913","url":null,"abstract":"Objective \u0000To explore the relationship between total MRI burden and serum homocysteine (Hcy) in patients with cerebral small vessel disease(CSVD), and to provide clues for disease prevention and treatment. \u0000 \u0000 \u0000Methods \u0000A total of 370 inpatients with CSVD from the neurology department of hospital were consecutively enrolled from September 2016 to December 2018.The clinical data, including serum homocysteine(Hcy) levels were collected.Brain MRI data were collected, including the severity of white matter hyperintensities(WMH), lacune infarcts(LI), cerebral microbleeds(CMBs), and enlarged perivascular spaces(ePVS) to evaluate the total load of CSVD.SPSS21.0 was applied to analyze the association between total CSVD burden and Hcy. \u0000 \u0000 \u0000Results \u0000(1)Compared with the patients with lower Hcy levels, the higher Hcy group had heavier total burdens of CSVD(P<0.01). (2)According to the total MRI burden scores of CSVD, all patients were further divided into low burden group(106 cases) and moderate-high burden group(264 cases). Multivariate logistic regression analysis showed that Hcy(OR=1.026, 95%CI: 1.003-1.049, P=0.026) was risk factor for increasing CSVD burden and hyperhomocysteinemia was a stronger predictor for total MRI burdens of CSVD(OR=3.202, 95%CI: 1.947-5.268, P<0.001). \u0000 \u0000 \u0000Conclusion \u0000Serum Hcy can be an independent risk factor for the total MRI burdens of CSVD.This finding provides a promising clue for the prediction and clinical management of CSVD. \u0000 \u0000 \u0000Key words: \u0000Cerebral small vessel disease; Risk factor; Magnetic resonance imaging; Homocysteine","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"29 1","pages":"233-238"},"PeriodicalIF":0.0,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43150702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Correlation of white matter microstructural changes with executive function impairment in patients with white matter lesions 白质病变患者白质微观结构变化与执行功能损害的相关性
Pub Date : 2020-03-20 DOI: 10.3760/CMA.J.CN371468-20190924-00678
Yanling Ma, Hongyan Chen, Jinfang Wang, Na Ye, Shinan Wang, Li Feng, Yue-xiu Li, Qingli Shi, Weili Jia, Yumei Zhang
Objective To explore abnormal microstructural changes of white matter in patients with white matter lesions(WML) using diffusion tensor imaging(DTI), and to determine the association of such abnormalities of DTI parameters with executive function. Methods Totally 34 patients with WML were recruited from the department of Neurology, Beijing Tiantan Hospital, Capital Medical University from March 2012 to May 2019.All patients with WML were scored with Hamilton depression scale (HAMD) and Hamilton anxiety scale (HAMA), and assessed with Montreal cognitive assessment (MoCA) and clinical dementia rating(CDR). They were divided into WML-cognitive normal group, WML-vascular cognitive impairment-non dementia group and WML-Dementia group.The Stroop color and word test (SCWT), trail making test-A (TMTA), digit symbol test and verbal fluency test were carried out to evaluate executive function.In addition, the healthy elderly without WML lesions were selected as the control group after they were examined by MRI, and all brains of the subjects went through DTI with Siemens 3.0 T MR.The data were collected and analyzed by voxel based analysis (VBA). The anisotropy and mean diffusion coefficient of DTI in the region of interest (ROI) and other regions in the brain were studied in the four groups, and their correlation with scores of executive function in WML patients was analyzed. Results (1)In these executive function test, there were significant differences between the patients with cognitive impairment (WML-VAD group, WML-VCIND group) and normal cognition group(WML-CN group, NC group), such as SCWT(B)(65.54±6.24 vs 43.67±0.95, 76.75±2.13 vs 43.67±0. 95, 65.54±6.24 vs 43.66±1.81, 76.75±2.13 vs 43.66±1.81), SCWT(C)(88.58±6.76 vs 61.63±1.31, 96.37±1.47 vs 61 63±1.31, 88.58±6.76 vs 66.31±8.19, 96.37±1.47 vs 66.31±8.19), TMTA(40.47±2.76 vs 30.92±0.47, 44.24±1.43 vs 30.92±0.47, 44.24±1.43 vs 31.99±2.07, 40.47±2.76 vs 31.99±2.07), TMTB(88.66±6.55 vs 80.34±0.61, 96.70±1.72 vs 80.34±0.61, 88.66±6.55 vs 83.10±5.91, 96.70±1.72 vs 83. 10±5.91), Digit Symbol Test(39.25±5.63 vs 47.00±2.55, 31.27±3.93 vs 47.00±2.5, 39.25±5.63 vs 48.86±4.34, 31.27±3.93 vs 48.86±4.34) and Verbal Fluency Test(8.94±1.00 vs 11.71±0.47, 6.64±0.81 vs 11.71±0.47, 8.94±1.00 vs 10.86±0.69, 6.64±0.81 vs 10.86±0.69) scores (P<0.05); In the patients with cognitive impairment, there were significant differences between WML-VAD group and WML-VCIND group, such as SCWT(B), SCWT(C), TMTA, TMTB, digit symbol test and verbal fluency test scores (P<0.05); There were significant differences between WML-CN patients and NC group in the scores of SCWT (C), verbal fluency test(P<0.05). (2)FA values in the genu of corpus callosum and the inferior longitudinal fasciculus were negatively correlated with the time of SCWT (B), SCWT (C) and the TMTA(r=-0.436--0.471), but positively correlated with the scores of digit symbol test and verbal fluency test(r=0.428-0.573). MD values in the genu of corpus callosu
目的应用弥散张量成像(DTI)技术探讨白质病变(WML)患者白质微观结构的异常变化,并探讨DTI参数异常与执行功能的关系。方法选取首都医科大学北京天坛医院神经内科2012年3月至2019年5月收治的34例WML患者,采用汉密尔顿抑郁量表(HAMD)和汉密尔顿焦虑量表(HamMA)对其进行评分,并采用蒙特利尔认知评定(MoCA)和临床痴呆评定(CDR)对其评分。他们被分为WML认知正常组、WML血管性认知障碍非痴呆组和WML痴呆组。采用Stroop颜色和单词测试(SCWT)、线索制作测试-A(TMTA)、数字符号测试和语言流利性测试来评估执行功能。此外,选择没有WML病变的健康老年人作为对照组,在MRI检查后,所有受试者的大脑都用Siemens 3.0T MR进行DTI。数据收集并通过基于体素的分析(VBA)进行分析。研究了四组患者大脑感兴趣区(ROI)和其他区域DTI的各向异性和平均扩散系数,并分析了它们与WML患者执行功能评分的相关性。结果(1)在这些执行功能测试中,认知障碍患者(WML-VAD组、WML-VCIND组)与正常认知组(WML-CN组、NC组)之间存在显著差异,如SCWT(B)(65.54±6.24 vs 43.67±0.95,76.75±2.13 vs 43.67士0)。95,65.54±6.24 vs 43.66±1.81,76.75±2.13 vs 43.66士1.81),SCWT(C)(88.58±6.76 vs 61.63±1.31,96.37±1.47 vs 61.63士1.31,88.58±67.6 vs 66.31±8.19,96.37士1.47 vs 66.31士8.19),TMTA,TMTB(88.66±6.55 vs 80.34±0.61,96.70±1.72 vs 80.34士0.61,88.66±6.5 5 vs 83.10±5.91,96.7±1.72 vs.83。10±5.91)、数字符号测试(39.25±5.63 vs 47.00±2.55,31.27±3.93 vs 47.0±2.5,39.25±56.3 vs 48.86±4.34,31.27士3.93 vs 48.86%±4.34)和语言流利度测试(8.94±1.00 vs 11.71±0.47,6.64±0.81 vs 11.71士0.47,8.94±1.00vs 10.86±0.69,6.64士0.81 vs 10.86士0.69)得分(P<0.05);在认知障碍患者中,WML-VAD组与WML-VCIND组在SCWT(B)、SCWT(C)、TMTA、TMTB、数字符号测试和语言流利性测试得分方面存在显著差异(P<0.05);WML-CN患者与NC组在SCWT(C)、语言流利性测试得分上存在显著差异(P<0.05),胼胝体膝、上下纵束和额枕下束MD值与SCWT(B)、SCWT(C)和TMTA时间呈正相关(r=0.432~0.609),但与数字符号测试和语言流利性测试的得分呈负相关(r=-0.424--0.630,校正后均P<0.003125)。结论WML痴呆患者的执行功能明显下降。白质微观结构的破坏越严重,功能执行的破坏就越严重。关键词:白质病变;认知障碍;扩散张量成像;白质纤维
{"title":"Correlation of white matter microstructural changes with executive function impairment in patients with white matter lesions","authors":"Yanling Ma, Hongyan Chen, Jinfang Wang, Na Ye, Shinan Wang, Li Feng, Yue-xiu Li, Qingli Shi, Weili Jia, Yumei Zhang","doi":"10.3760/CMA.J.CN371468-20190924-00678","DOIUrl":"https://doi.org/10.3760/CMA.J.CN371468-20190924-00678","url":null,"abstract":"Objective \u0000To explore abnormal microstructural changes of white matter in patients with white matter lesions(WML) using diffusion tensor imaging(DTI), and to determine the association of such abnormalities of DTI parameters with executive function. \u0000 \u0000 \u0000Methods \u0000Totally 34 patients with WML were recruited from the department of Neurology, Beijing Tiantan Hospital, Capital Medical University from March 2012 to May 2019.All patients with WML were scored with Hamilton depression scale (HAMD) and Hamilton anxiety scale (HAMA), and assessed with Montreal cognitive assessment (MoCA) and clinical dementia rating(CDR). They were divided into WML-cognitive normal group, WML-vascular cognitive impairment-non dementia group and WML-Dementia group.The Stroop color and word test (SCWT), trail making test-A (TMTA), digit symbol test and verbal fluency test were carried out to evaluate executive function.In addition, the healthy elderly without WML lesions were selected as the control group after they were examined by MRI, and all brains of the subjects went through DTI with Siemens 3.0 T MR.The data were collected and analyzed by voxel based analysis (VBA). The anisotropy and mean diffusion coefficient of DTI in the region of interest (ROI) and other regions in the brain were studied in the four groups, and their correlation with scores of executive function in WML patients was analyzed. \u0000 \u0000 \u0000Results \u0000(1)In these executive function test, there were significant differences between the patients with cognitive impairment (WML-VAD group, WML-VCIND group) and normal cognition group(WML-CN group, NC group), such as SCWT(B)(65.54±6.24 vs 43.67±0.95, 76.75±2.13 vs 43.67±0. 95, 65.54±6.24 vs 43.66±1.81, 76.75±2.13 vs 43.66±1.81), SCWT(C)(88.58±6.76 vs 61.63±1.31, 96.37±1.47 vs 61 63±1.31, 88.58±6.76 vs 66.31±8.19, 96.37±1.47 vs 66.31±8.19), TMTA(40.47±2.76 vs 30.92±0.47, 44.24±1.43 vs 30.92±0.47, 44.24±1.43 vs 31.99±2.07, 40.47±2.76 vs 31.99±2.07), TMTB(88.66±6.55 vs 80.34±0.61, 96.70±1.72 vs 80.34±0.61, 88.66±6.55 vs 83.10±5.91, 96.70±1.72 vs 83. 10±5.91), Digit Symbol Test(39.25±5.63 vs 47.00±2.55, 31.27±3.93 vs 47.00±2.5, 39.25±5.63 vs 48.86±4.34, 31.27±3.93 vs 48.86±4.34) and Verbal Fluency Test(8.94±1.00 vs 11.71±0.47, 6.64±0.81 vs 11.71±0.47, 8.94±1.00 vs 10.86±0.69, 6.64±0.81 vs 10.86±0.69) scores (P<0.05); In the patients with cognitive impairment, there were significant differences between WML-VAD group and WML-VCIND group, such as SCWT(B), SCWT(C), TMTA, TMTB, digit symbol test and verbal fluency test scores (P<0.05); There were significant differences between WML-CN patients and NC group in the scores of SCWT (C), verbal fluency test(P<0.05). (2)FA values in the genu of corpus callosum and the inferior longitudinal fasciculus were negatively correlated with the time of SCWT (B), SCWT (C) and the TMTA(r=-0.436--0.471), but positively correlated with the scores of digit symbol test and verbal fluency test(r=0.428-0.573). MD values in the genu of corpus callosu","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"29 1","pages":"239-244"},"PeriodicalIF":0.0,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45543035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect and possible mechanism of sevoflurane exposure on electroencephalographic seizures and long-term cognitive function in neonatal rats 七氟醚暴露对新生大鼠脑电图发作和长期认知功能的影响及其可能机制
Pub Date : 2020-03-20 DOI: 10.3760/CMA.J.CN371468-20190921-00661
Jie Wang, Baofeng Yang, Zheng Yang, Ningtao Li, Mingyang Sun, Jiaqiang Zhang
Objective To investigate the effect of sevoflurane anesthesia on electroencephalographic (EEG) seizures and long-term behavior and possible mechanism in neonatal rats. Methods A total of 141 postnatal days 4-6 Sprague-Dawley rats (66 male, 75 female) were divided into 3 groups (n=47 in each group) according to random number table method: control group, sevoflurane group, and NKCC1 inhibitor group, with 22 males and 25 females in each group. Rats in the control group were fed in normal cage without anesthesia; rats in the sevoflurane group were anesthetized with 2.1% sevoflurane for 6 hours; rats in the NKCC1 blocker group received intraperitoneal injection of 1.82 mg / kg bumetanide 30 minutes before anesthesia with 2.1% sevoflurane. The rats in the control group and sevoflurane group were injected subcutaneously with the same dose of DMSO at the same time when the NKCC1 blocker group received the drug intervention, so as to eliminate the influence caused by the solvent. The rats were observed for 30 minutes after recovery from anesthesia and then continued to breastfeed normally. Some of the new born rats received EEG monitoring from 9 to 11 days after being raised; the other rats received EPM and PPI respectively at 60 and 70 days after being raised. Results The results of EEG showed that, compared with the control group, the number of epileptic waves((0.429±0.787), (1.571±0.787), t=2.753, P 0.05). Compared with male rats, the average duration of female rats in sevoflurane group decreased ((6.392±3.374), (2.515±2.992), t=3.044, P 0.05). Comparison between male and female rats: compared with male rats in sevoflurane group, the female rats in sevoflurane group had a longer open arm stay time in EPM experiment (P<0.05), the difference was statistically significant. Conclusion Sevoflurane anesthesia for 6 hours can significantly increase the generation of epileptic waves in EEG of male newborn rats, and cause behavioral abnormalities in adult male rats, which may be related to NKCC1.And male rats are more vulnerable to the negative effects of sevoflurane anesthesia on brain nerve development. Key words: Sevoflurane; Neonatal anesthesia; Bumetanide; Gender; Electroencephalo-graphic; Behaviour; Rat
目的探讨七氟醚麻醉对新生大鼠脑电图(EEG)发作及长期行为的影响及其可能机制。方法采用随机数表法将141只出生后第4~6天的Sprague-Dawley大鼠(雄性66只,雌性75只)分为3组(每组47只):对照组、七氟醚组和NKCC1抑制剂组,每组雄性22只,雌性25只。对照组大鼠在不麻醉的情况下在正常笼中饲养;七氟醚组大鼠用2.1%七氟醚麻醉6小时;NKCC1阻断剂组大鼠在用2.1%七氟醚麻醉前30分钟腹膜内注射1.82mg/kg布美他奈。对照组和七氟醚组大鼠在NKCC1阻断剂组接受药物干预的同时皮下注射相同剂量的DMSO,以消除溶剂引起的影响。麻醉恢复后观察大鼠30分钟,然后继续正常母乳喂养。一些新生大鼠在饲养后9-11天接受脑电图监测;其他大鼠分别在饲养后60天和70天接受EPM和PPI。结果脑电图结果显示,与对照组相比,癫痫波数((0.429±0.787),(1.571±0.787,七氟醚组雌性大鼠在EPM实验中张开臂停留时间较长(P<0.05),差异有统计学意义。结论七氟醚麻醉6h可显著增加雄性新生大鼠脑电图中癫痫波的产生,并导致成年雄性大鼠行为异常,这可能与NKCC1有关。而且雄性大鼠更容易受到七氟醚麻醉对脑神经发育的负面影响。关键词:七氟烷;新生儿麻醉;布美他奈;性别;脑电图;行为;大鼠
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引用次数: 0
Effect of behavioral intervention on the prognosis of patients with carotid artery stenting 行为干预对颈动脉支架置入术患者预后的影响
Pub Date : 2020-03-20 DOI: 10.3760/CMA.J.CN371468-20191120-00885
Zhaoying Wu, Baojun Qiao, Hui Yan, Chen Chen, Shuhu Zhou, Yanlei Hao
Objective To explore the effects of behavior intervention on patients with ischemic cerebrovascular disease recurrence, carotid artery stenosis recurrence, and quality of life after carotid artery stenting implantation. Methods Sixty patients with carotid stenosis who underwent stenting surgery between January 2017 and July 2018 in Affiliated Hospital of Jining Medical University were recruited.The subjects were randomly divided into behavioral intervention group and control group.The control group was routinely followed up after carotid artery stenting implantation.The behavioral intervention group added home visit, education, guidance of the control and detection of risk factors for cerebrovascular disease of stent implantation. Results After 12 months of intervention, the incidence of ischemic cerebrovascular disease and the recurrence rate of carotid restenosis in the behavioral intervention group(6.7%, 3.3%) were significantly lower than those in the control group(30.0%, 20.0%) (both P<0.05). Six months after the intervention and 12 months after the intervention, the self-management ability score (intervention group: six months after the intervention (171.20±18.43), 12 months after the intervention (179.90±14.34); control group: six months after the intervention (160.77±13.43); 12 months after the intervention (164.27±14.85)) and quality of SS-QOL score (intervention group: 6 months after intervention (188.47±16.25), 12 months after intervention (203.17±13.84); control group: 6 months after intervention (170.67±15.82); 12 months after intervention (183.80±18.19)of the intervention group were higher than that of the control group, the difference is statistically significant (all P<0.05). Conclusion Behavioral intervention after carotid artery stenting implantation can effectively reduce the incidence of stroke and the recurrence rate of carotid stenosis and improve the prognosis of patients.The mechanism may be related with that the behavioral intervention can improve the self-management ability and the quality of life of patients with carotid stenosis. Key words: Behavioral intervention; Carotid stenosis stent implantation; Recurrence of carotid stenosis; Prognosis
目的探讨行为干预对缺血性脑血管病复发、颈动脉狭窄复发及颈动脉支架置入术后生活质量的影响。方法选择2017年1月至2018年7月在济宁医科大学附属医院接受支架置入术的颈动脉狭窄患者60例。受试者被随机分为行为干预组和对照组。对照组在颈动脉支架植入术后进行常规随访。行为干预组增加了家访、教育、指导支架置入术控制和检测脑血管疾病危险因素。结果干预12个月后,行为干预组缺血性脑血管病发生率和颈动脉再狭窄复发率(6.7%、3.3%)明显低于对照组(30.0%、20.0%)(均P<0.05),自我管理能力评分(干预组:干预后6个月(171.20±18.43),干预后12个月(179.90±14.34);对照组:干预后6个月(160.77±13.43);干预后12个月(164.27±14.85))和SS-QOL评分质量(干预组:干预后6个月(188.47±16.25),干预后12月(203.17±13.84);对照组:干预后6个月(170.67±15.82);干预组干预12个月后(183.80±18.19)明显高于对照组,差异有统计学意义(均P<0.05)。其机制可能与行为干预能够提高颈动脉狭窄患者的自我管理能力和生活质量有关。关键词:行为干预;颈动脉狭窄支架植入术;颈动脉狭窄复发;预后
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引用次数: 0
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中华行为医学与脑科学杂志
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