Objective To investigate and analyze the somatic symptom disorder, anxiety and depression in patients with myocardial bridge. Methods A total of 276 patients with myocardial bridge diagnosed by coronary angiography (CAG) were enrolled in the department of cardiology of Renji hospital in Shanghai from June to December in 2016. There were 151 cases of simple myocardial bridge (no coronary stenosis or coronary artery stenosis 30%). A total of 1067 patients with myocardial bridge without coronary angiography were collected at the same time. Self-rating somatic symptom scale (SSS), generalized anxiety disorder (GAD-7) and patient health questionnaire (PHQ -9) were given to these patients during hospitalization. At the same time, somatic symptoms disorder and anxiety and depression in the myocardial bridge group and non-myocardial bridge group were compared. Results The prevalence of somatic symptom disorder in patients with myocardial bridge was higher than that in non-myocardial bridge patients (35.86% vs 28.30%, P<0.05). There was significant correlation between somatic symptom disorder and depression and anxiety, with correlation coefficients of 0.629 and 0.565, respectively. The prevalence of depression and anxiety in myocardial bridge patients was higher than that in non-myocardial bridge patients (depression: 23.91% vs 22.11%. P=0.467; anxiety: 17.02% vs 14.15%, P=0.22), but there was no statistical difference. For male patients or female patients, the prevalence of somatic symptom disorder, depression and anxiety in the simple myocardial bridge patients were higher than those in the complex myocardial bridge patients, but there was no statistical difference. The most common non-specific somatic symptoms disorder in patients with myocardial bridge were fatigue (64.5%), followed by sleep disorders (63.8%) and decreased attention (63.0%). Conclusion The somatic symptom disorder in patients with myocardial bridge is significantly higher than that in non-myocardial bridge group. Especially for patients with myocardial bridge with non-specific somatic symptoms, early identification of somatic symptoms disorder of myocardial bridge patients will be beneficial to proper clinical invitation. Key words: Myocardial bridge; Somatic symptom disorder; Anxiety; Depression
{"title":"Investigation and analysis of somatic symptom disorder and anxiety and depression in patients with myocardial bridge","authors":"BingXu Chen, Yi-xuan Li, Yuzhuo Liu, Xiao Guan, Meng Jiang, Jia-liang Mao","doi":"10.3760/CMA.J.CN371468-20190827-00559","DOIUrl":"https://doi.org/10.3760/CMA.J.CN371468-20190827-00559","url":null,"abstract":"Objective \u0000To investigate and analyze the somatic symptom disorder, anxiety and depression in patients with myocardial bridge. \u0000 \u0000 \u0000Methods \u0000A total of 276 patients with myocardial bridge diagnosed by coronary angiography (CAG) were enrolled in the department of cardiology of Renji hospital in Shanghai from June to December in 2016. There were 151 cases of simple myocardial bridge (no coronary stenosis or coronary artery stenosis 30%). A total of 1067 patients with myocardial bridge without coronary angiography were collected at the same time. Self-rating somatic symptom scale (SSS), generalized anxiety disorder (GAD-7) and patient health questionnaire (PHQ -9) were given to these patients during hospitalization. At the same time, somatic symptoms disorder and anxiety and depression in the myocardial bridge group and non-myocardial bridge group were compared. \u0000 \u0000 \u0000Results \u0000The prevalence of somatic symptom disorder in patients with myocardial bridge was higher than that in non-myocardial bridge patients (35.86% vs 28.30%, P<0.05). There was significant correlation between somatic symptom disorder and depression and anxiety, with correlation coefficients of 0.629 and 0.565, respectively. The prevalence of depression and anxiety in myocardial bridge patients was higher than that in non-myocardial bridge patients (depression: 23.91% vs 22.11%. P=0.467; anxiety: 17.02% vs 14.15%, P=0.22), but there was no statistical difference. For male patients or female patients, the prevalence of somatic symptom disorder, depression and anxiety in the simple myocardial bridge patients were higher than those in the complex myocardial bridge patients, but there was no statistical difference. The most common non-specific somatic symptoms disorder in patients with myocardial bridge were fatigue (64.5%), followed by sleep disorders (63.8%) and decreased attention (63.0%). \u0000 \u0000 \u0000Conclusion \u0000The somatic symptom disorder in patients with myocardial bridge is significantly higher than that in non-myocardial bridge group. Especially for patients with myocardial bridge with non-specific somatic symptoms, early identification of somatic symptoms disorder of myocardial bridge patients will be beneficial to proper clinical invitation. \u0000 \u0000 \u0000Key words: \u0000Myocardial bridge; Somatic symptom disorder; Anxiety; Depression","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"29 1","pages":"130-135"},"PeriodicalIF":0.0,"publicationDate":"2020-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44662826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-20DOI: 10.3760/CMA.J.CN371468-20191213-00912
Da-yu Wang, Xiao-yan Ye, Yan Xu
Objective To investigate the expression of triggering receptor expressed on myeloid cells(TREMs)in periventricular leukomalacia(PVL) of the neonatal rat model. Methods Thirty-two 3-day-old neonatal rats were double-blinded randomly divided into Sham group and Model group.The PVL rat model was established by ligating right carotid artery and oxygen deprivation.Hematoxylin-eosin (HE) was adopted to compare pathological changes of brain tissue between the two groups, and immunofluorescence was adopted to detect the expression of myline basic protein (MBP) in the right hemisphere of the two groups.Western blot was performed to detect the expression of TREM1 and TREM2 in the right hemisphere of the two groups. Results The results of HE staining showed that the brain tissues of Model group were significantly damaged compared with that of Sham group, and the mean fluorescence intensity of MBP in Model group(26.629±2.317) was significantly lower than that in Sham group(33.579±2.824), with statistically significant differences(t=9.124, P<0.05). The expression of TREM1 in Model group(0.789 ±0.120) was higher than that in Sham group(0.567±0.093), with statistically significant differences(t=-3.891, P<0.05). The expression of TREM2 in Model group(0.544±0.133) was lower than that in Sham group(0.791±0.118), with statistically significant differences(t=3.667, P<0.05). Conclusion The expressions of TREM1 and TREM2 in the neonatal rat model of PVL change abnormally, suggesting that TREMs may be involved in the pathological process of preterm white matter injury. Key words: Periventricular leukomalacia; White matter injury; Brain injury; Triggering receptor expressed on myeloid cells; Rat
{"title":"Expression of triggering receptor expressed on myeloid cells in periventricular leukomalacia of neonatal rat model","authors":"Da-yu Wang, Xiao-yan Ye, Yan Xu","doi":"10.3760/CMA.J.CN371468-20191213-00912","DOIUrl":"https://doi.org/10.3760/CMA.J.CN371468-20191213-00912","url":null,"abstract":"Objective \u0000To investigate the expression of triggering receptor expressed on myeloid cells(TREMs)in periventricular leukomalacia(PVL) of the neonatal rat model. \u0000 \u0000 \u0000Methods \u0000Thirty-two 3-day-old neonatal rats were double-blinded randomly divided into Sham group and Model group.The PVL rat model was established by ligating right carotid artery and oxygen deprivation.Hematoxylin-eosin (HE) was adopted to compare pathological changes of brain tissue between the two groups, and immunofluorescence was adopted to detect the expression of myline basic protein (MBP) in the right hemisphere of the two groups.Western blot was performed to detect the expression of TREM1 and TREM2 in the right hemisphere of the two groups. \u0000 \u0000 \u0000Results \u0000The results of HE staining showed that the brain tissues of Model group were significantly damaged compared with that of Sham group, and the mean fluorescence intensity of MBP in Model group(26.629±2.317) was significantly lower than that in Sham group(33.579±2.824), with statistically significant differences(t=9.124, P<0.05). The expression of TREM1 in Model group(0.789 ±0.120) was higher than that in Sham group(0.567±0.093), with statistically significant differences(t=-3.891, P<0.05). The expression of TREM2 in Model group(0.544±0.133) was lower than that in Sham group(0.791±0.118), with statistically significant differences(t=3.667, P<0.05). \u0000 \u0000 \u0000Conclusion \u0000The expressions of TREM1 and TREM2 in the neonatal rat model of PVL change abnormally, suggesting that TREMs may be involved in the pathological process of preterm white matter injury. \u0000 \u0000 \u0000Key words: \u0000Periventricular leukomalacia; White matter injury; Brain injury; Triggering receptor expressed on myeloid cells; Rat","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"29 1","pages":"109-113"},"PeriodicalIF":0.0,"publicationDate":"2020-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43214887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-20DOI: 10.3760/CMA.J.CN371468-20190415-00253
Yuluo Liu, Longda Ma, Fang-mei Huang, Zilong Liu
Patients with brain injury are often accompanied by emotional disorders, which can cause a variety of mental disorders, and mental disorders will continue to exist after rehabilitation, seriously affecting the ability of patients to adapt and integrate into society, greatly reducing the quality of life.Therefore, the research on the mechanism of emotional disorders after brain injury is of great significance to the clinical prevention and treatment of mental disorders related to emotional disorders.Functional magnetic resonance imaging (fMRI) provides a more intuitive and accurate research method for the study of emotional regulation, so many scholars have conducted in-depth research on emotional disorders after craniocerebral injury from different perspectives.In this paper, the functional MRI studies of emotional disorders were reviewed after craniocerebral injury in the past decade and most of the resting MRI studies showed that the mechanism of emotional disorders after craniocerebral injury is related to the imbalance of interaction among the resting default network, executive network and salience network, while the task MRI studies found that the amygdala, dorsolateral prefrontal lobe and anterior Cingulate gyrus and right inferior frontal gyrus played an important role in attention distribution, cognitive reappraisal, expression inhibition and other emotional regulation strategies, and the damage of these brain regions will cause corresponding emotional regulation disorders.In this paper, the neural mechanism and research progress of emotional disorders after brain injury were systematically reviewed, summarize the existing problems, and propose possible solutions from the perspective of resting and task state functional MRI. Key words: Traumatic brain injury; Emotion dysregulation; Functional magnetic resonance imaging
{"title":"Progress in functional magnetic resonance imaging of emotion dysregulation due to traumatic brain injury","authors":"Yuluo Liu, Longda Ma, Fang-mei Huang, Zilong Liu","doi":"10.3760/CMA.J.CN371468-20190415-00253","DOIUrl":"https://doi.org/10.3760/CMA.J.CN371468-20190415-00253","url":null,"abstract":"Patients with brain injury are often accompanied by emotional disorders, which can cause a variety of mental disorders, and mental disorders will continue to exist after rehabilitation, seriously affecting the ability of patients to adapt and integrate into society, greatly reducing the quality of life.Therefore, the research on the mechanism of emotional disorders after brain injury is of great significance to the clinical prevention and treatment of mental disorders related to emotional disorders.Functional magnetic resonance imaging (fMRI) provides a more intuitive and accurate research method for the study of emotional regulation, so many scholars have conducted in-depth research on emotional disorders after craniocerebral injury from different perspectives.In this paper, the functional MRI studies of emotional disorders were reviewed after craniocerebral injury in the past decade and most of the resting MRI studies showed that the mechanism of emotional disorders after craniocerebral injury is related to the imbalance of interaction among the resting default network, executive network and salience network, while the task MRI studies found that the amygdala, dorsolateral prefrontal lobe and anterior Cingulate gyrus and right inferior frontal gyrus played an important role in attention distribution, cognitive reappraisal, expression inhibition and other emotional regulation strategies, and the damage of these brain regions will cause corresponding emotional regulation disorders.In this paper, the neural mechanism and research progress of emotional disorders after brain injury were systematically reviewed, summarize the existing problems, and propose possible solutions from the perspective of resting and task state functional MRI. \u0000 \u0000 \u0000Key words: \u0000Traumatic brain injury; Emotion dysregulation; Functional magnetic resonance imaging","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"29 1","pages":"189-192"},"PeriodicalIF":0.0,"publicationDate":"2020-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49230723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-20DOI: 10.3760/CMA.J.CN371468-20190905-00607
Jing Li, Fuqiang Mao, Zhi-hua Zhang, Yibo Li, Xu Wang, Tong Zhang, G. Wang
Objective To evaluate the intervention effect of Naikan cognitive therapy (NCT)on psychosomatic symptoms of female compulsory drug addicts. Methods Seventy drug addicts who met the inclusion criteria and volunteered to participate in the study were selected and randomly divided into intervention group(n=35) and control group(n=35) with random number table method.The intervention group received 10 consecutive days of NCT, while the control group received the same period of mental health education.Before and after treatment, the two groups were assessed with symptoms check list-90(SCL-90), preceived social support scale(PSSS), simple coping style scale(SCSQ) and inclination of relapse questionnaire of drug rehabilitated addicts. Results There was no significant difference between the two groups before the intervention (all P>0.05). Compared with pre-intervention, the total score of SCL-90((176.49±40.85) vs (152.60±31.17)), somatization, compulsion, interpersonal sensitivity, depression, anxiety, terror, paranoid and psychiatric factors were significantly decreased and the total scores of PSSS((59.09±14.60) vs (64.43±10.42)) family support, friend support and other support subscales increased significantly post-NCT intervention in the intervention group (all P 0.05). Conclusion Naikan cognitive therapy can significantly improve the psychosomatic symptoms perceive social support and positive coping styles, and reduce the tendency of negative coping and relapse of female compulsory drug addicts. Key words: Naikan cognitive therapy; Compulsory drug addicts; Physical and psychological symptoms; Relapse tendency
{"title":"Effect of Naikan cognitive therapy intervention on psychosomatic symptoms of female compulsory drug abuse addicts","authors":"Jing Li, Fuqiang Mao, Zhi-hua Zhang, Yibo Li, Xu Wang, Tong Zhang, G. Wang","doi":"10.3760/CMA.J.CN371468-20190905-00607","DOIUrl":"https://doi.org/10.3760/CMA.J.CN371468-20190905-00607","url":null,"abstract":"Objective \u0000To evaluate the intervention effect of Naikan cognitive therapy (NCT)on psychosomatic symptoms of female compulsory drug addicts. \u0000 \u0000 \u0000Methods \u0000Seventy drug addicts who met the inclusion criteria and volunteered to participate in the study were selected and randomly divided into intervention group(n=35) and control group(n=35) with random number table method.The intervention group received 10 consecutive days of NCT, while the control group received the same period of mental health education.Before and after treatment, the two groups were assessed with symptoms check list-90(SCL-90), preceived social support scale(PSSS), simple coping style scale(SCSQ) and inclination of relapse questionnaire of drug rehabilitated addicts. \u0000 \u0000 \u0000Results \u0000There was no significant difference between the two groups before the intervention (all P>0.05). Compared with pre-intervention, the total score of SCL-90((176.49±40.85) vs (152.60±31.17)), somatization, compulsion, interpersonal sensitivity, depression, anxiety, terror, paranoid and psychiatric factors were significantly decreased and the total scores of PSSS((59.09±14.60) vs (64.43±10.42)) family support, friend support and other support subscales increased significantly post-NCT intervention in the intervention group (all P 0.05). \u0000 \u0000 \u0000Conclusion \u0000Naikan cognitive therapy can significantly improve the psychosomatic symptoms perceive social support and positive coping styles, and reduce the tendency of negative coping and relapse of female compulsory drug addicts. \u0000 \u0000 \u0000Key words: \u0000Naikan cognitive therapy; Compulsory drug addicts; Physical and psychological symptoms; Relapse tendency","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"29 1","pages":"125-129"},"PeriodicalIF":0.0,"publicationDate":"2020-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48798698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-20DOI: 10.3760/CMA.J.CN371468-20190605-00364
Xianqiang Zhang, Bo Lian, Changjiang Li, Guohua Lu, Hongwei Sun, Lin Sun
Major depressive disorder is a mental illness characterized by depressed mood, lack of engagement in pleasurable activities, anhedonia, and cognitive-behavioral disorders. Currently, traditional pharmacological treatments for depression have a delayed therapeutic onset and low treatment effectiveness. (2R, 6R)-HNK, as a key metabolite of ketamine, can not only exert rapid and lasting antidepressant effects but also has no side effects such as hallucination and addiction caused by ketamine, which has potential clinical application values. Studies have found that the antidepressant effect of (2R, 6R)-HNK is closely related to the regulation mechanism of glutamate receptor and synaptic plasticity. Besides, the changes of downstream signaling pathways include the upregulation of brain-derived neurotrophic factor (BDNF) expression, dephosphorylation of eukaryotic elongation factor 2 (eEF2), and activation of the mammalian target of rapamycin (mTOR) play a key role in the antidepressant process of the drug. Understanding the molecular mechanisms underpinning (2R, 6R)-HNK's antidepressant effects will be invaluable for the identification of targets, which will drive the development of novel, effective, next-generation pharmacotherapies for the treatment of depression. Key words: Depression; (2R, 6R)-hydronorketamine; Glutamate; Antidepressant
{"title":"Research progress on the mechanism of rapid antidepressant action of hydronorketamine","authors":"Xianqiang Zhang, Bo Lian, Changjiang Li, Guohua Lu, Hongwei Sun, Lin Sun","doi":"10.3760/CMA.J.CN371468-20190605-00364","DOIUrl":"https://doi.org/10.3760/CMA.J.CN371468-20190605-00364","url":null,"abstract":"Major depressive disorder is a mental illness characterized by depressed mood, lack of engagement in pleasurable activities, anhedonia, and cognitive-behavioral disorders. Currently, traditional pharmacological treatments for depression have a delayed therapeutic onset and low treatment effectiveness. (2R, 6R)-HNK, as a key metabolite of ketamine, can not only exert rapid and lasting antidepressant effects but also has no side effects such as hallucination and addiction caused by ketamine, which has potential clinical application values. Studies have found that the antidepressant effect of (2R, 6R)-HNK is closely related to the regulation mechanism of glutamate receptor and synaptic plasticity. Besides, the changes of downstream signaling pathways include the upregulation of brain-derived neurotrophic factor (BDNF) expression, dephosphorylation of eukaryotic elongation factor 2 (eEF2), and activation of the mammalian target of rapamycin (mTOR) play a key role in the antidepressant process of the drug. Understanding the molecular mechanisms underpinning (2R, 6R)-HNK's antidepressant effects will be invaluable for the identification of targets, which will drive the development of novel, effective, next-generation pharmacotherapies for the treatment of depression. \u0000 \u0000 \u0000Key words: \u0000Depression; (2R, 6R)-hydronorketamine; Glutamate; Antidepressant","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"29 1","pages":"183-188"},"PeriodicalIF":0.0,"publicationDate":"2020-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46654346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-18DOI: 10.3760/CMA.J.ISSN.1674-6554.2020.0001
J. Ji
The death of a family member died with the novel coronavirus pneumonia is a special traumatic stress to the other family members and they will bear unbelievable distress and dramatic sorrow. The grief responses can be divided into normal grief responses and abnormal grief responses. The latter are much stronger, more severe, last longer and the responses can be delayed or inhibited or distorted. The management of abnormal grief responses includes counseling, supportive group, psychotherapy and medications.
{"title":"The recommendation for management of the bereavements among the family members died with novel coronavirus pneumonia/ 中华行为医学与脑科学杂志","authors":"J. Ji","doi":"10.3760/CMA.J.ISSN.1674-6554.2020.0001","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-6554.2020.0001","url":null,"abstract":"The death of a family member died with the novel coronavirus pneumonia is a special traumatic stress to the other family members and they will bear unbelievable distress and dramatic sorrow. The grief responses can be divided into normal grief responses and abnormal grief responses. The latter are much stronger, more severe, last longer and the responses can be delayed or inhibited or distorted. The management of abnormal grief responses includes counseling, supportive group, psychotherapy and medications.","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42147238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-20DOI: 10.3760/CMA.J.CN371468-20190916-00621
Zhongxian Wang, Ai-guo Zhang, Yang Xu, Wenzhi Pei, Jie Chen, Xulai Zhang
Objective To explore the relationship between serum cytokine levels and cognitive impairment in patients with bipolar I manic episode. Methods Forty-four patients with bipolar I manic episode (BDI group) and 42 healthy volunteers (HC group) matched with demographic data were included.Peripheral serum interleukin-6 (IL-6), interleukin-10 (IL-10), interleukin-23 (IL-23), and tumor necrosis factor-α (TNF-α) levels were detected by enzyme-linked immunosorbent assay (ELISA). The repeatable battery for the assessment of neuropsychological status (RSPM) was used to evaluate the cognitive function of the two groups.Young manic rating scale (YMRS) was used to evaluate the clinical manic symptoms of patients.Hypothesis testing and correlation analysis were processed by SPSS 22.0. Results (1) The expression levels of serum cytokines IL-6, IL-10, IL-23 and TNF-α in BDI group ((38.872±7.803), (33.259±7.260), 42.350(33.600, 55.390), (108.309±19.398)) were significantly different with those in HC group ((24.664±6.083), (29.257±5.208), 17.360(12.870, 30.690), (68.674±13.610)), and the differences were statistically significant ((t=9.387, t=2.947, Z=-5.477, t=10.921, all P 0.05). Conclusion Patients with bipolar I disorder manic have changes in serum levels of cytokines and cognitive dysfunction. The course of disease and cognitive function are related with serum cytokine level. Key words: Bipolar disorder type I; Manic episode; Cytokines; Repetitive set of neuropsychological state tests
{"title":"Correlation between serum cytokine levels and cognitive function in patients with bipolar I manic episode","authors":"Zhongxian Wang, Ai-guo Zhang, Yang Xu, Wenzhi Pei, Jie Chen, Xulai Zhang","doi":"10.3760/CMA.J.CN371468-20190916-00621","DOIUrl":"https://doi.org/10.3760/CMA.J.CN371468-20190916-00621","url":null,"abstract":"Objective \u0000To explore the relationship between serum cytokine levels and cognitive impairment in patients with bipolar I manic episode. \u0000 \u0000 \u0000Methods \u0000Forty-four patients with bipolar I manic episode (BDI group) and 42 healthy volunteers (HC group) matched with demographic data were included.Peripheral serum interleukin-6 (IL-6), interleukin-10 (IL-10), interleukin-23 (IL-23), and tumor necrosis factor-α (TNF-α) levels were detected by enzyme-linked immunosorbent assay (ELISA). The repeatable battery for the assessment of neuropsychological status (RSPM) was used to evaluate the cognitive function of the two groups.Young manic rating scale (YMRS) was used to evaluate the clinical manic symptoms of patients.Hypothesis testing and correlation analysis were processed by SPSS 22.0. \u0000 \u0000 \u0000Results \u0000(1) The expression levels of serum cytokines IL-6, IL-10, IL-23 and TNF-α in BDI group ((38.872±7.803), (33.259±7.260), 42.350(33.600, 55.390), (108.309±19.398)) were significantly different with those in HC group ((24.664±6.083), (29.257±5.208), 17.360(12.870, 30.690), (68.674±13.610)), and the differences were statistically significant ((t=9.387, t=2.947, Z=-5.477, t=10.921, all P 0.05). \u0000 \u0000 \u0000Conclusion \u0000Patients with bipolar I disorder manic have changes in serum levels of cytokines and cognitive dysfunction. The course of disease and cognitive function are related with serum cytokine level. \u0000 \u0000 \u0000Key words: \u0000Bipolar disorder type I; Manic episode; Cytokines; Repetitive set of neuropsychological state tests","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"29 1","pages":"21-26"},"PeriodicalIF":0.0,"publicationDate":"2020-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49221003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective To explore the effects of magnanimous therapy on the magnanimous and enterprising traits of lung cancer patients and the analysis of related factors. Methods Totally 197 patients with lung cancer were divided into individual group (n=62), team group (n=75) and control group (n=60). Comparison and correlation analysis were applied to the data before and after the electroencephalogram and the magnanimous questionnaire, the cancer response questionnaire, the T-type psychological scale, the cancer heart state questionnaire and the cancer patient's life function index scale.t test, analysis of variance and Pearson correlation analysis were processed by SPSS 23.0. Results After treatment, the " enterprising" dimension and " magnanimous" dimension of individual group and the " enterprising" dimension of the team group ((3.035±0.309), (3.041±0.265), (3.173±0.371)) were higher than that before treatment((2.934±0.326), (2.908±0.315), (3.130±0.387), all P<0.05). There was negative correlation between " magnanimous" dimension of the magnanimous questionnaire and " subconscious" dimension of the T-type psychological scale in individual group(r=-0.280, P<0.05). In team group, the " enterprising" dimension of the magnanimous questionnaire was negatively correlated with " Psychological" and " Yield" dimension of the cancer heart state questionnaire(r=-0.279, -0.285, P<0.05), and positively correlated with " Facing" of the cancer response questionnaire, " Good physical condition and ability" and " Psychological well-being" dimension of the cancer patient's life function index scale(r=0.367, 0.402, 0.379, P<0.05). There was a negative correlation between the " enterprising" dimension of the magnanimous questionnaire and the beta wave value in individual group. Conclusion The magnanimous therapy can improve enterprising and magnanimous level of patients with lung cancer, and the effects are related with the above-mentioned psychosomatic factors. Key words: Magnanimous therapy; Enterprising and magnanimous psychology; Lung cancer patients; Efficacy; Related factors
{"title":"Effects of magnanimous therapy on the magnanimous and enterprising traits of lung cancer patients and related factors","authors":"Q. Ma, Qingxing Chen, A. Yan, Qianyu Liu, Lanlan Wu, Yue-Yue Wang, Xuewei Huang","doi":"10.3760/CMA.J.CN371468-20190916-00645","DOIUrl":"https://doi.org/10.3760/CMA.J.CN371468-20190916-00645","url":null,"abstract":"Objective \u0000To explore the effects of magnanimous therapy on the magnanimous and enterprising traits of lung cancer patients and the analysis of related factors. \u0000 \u0000 \u0000Methods \u0000Totally 197 patients with lung cancer were divided into individual group (n=62), team group (n=75) and control group (n=60). Comparison and correlation analysis were applied to the data before and after the electroencephalogram and the magnanimous questionnaire, the cancer response questionnaire, the T-type psychological scale, the cancer heart state questionnaire and the cancer patient's life function index scale.t test, analysis of variance and Pearson correlation analysis were processed by SPSS 23.0. \u0000 \u0000 \u0000Results \u0000After treatment, the \" enterprising\" dimension and \" magnanimous\" dimension of individual group and the \" enterprising\" dimension of the team group ((3.035±0.309), (3.041±0.265), (3.173±0.371)) were higher than that before treatment((2.934±0.326), (2.908±0.315), (3.130±0.387), all P<0.05). There was negative correlation between \" magnanimous\" dimension of the magnanimous questionnaire and \" subconscious\" dimension of the T-type psychological scale in individual group(r=-0.280, P<0.05). In team group, the \" enterprising\" dimension of the magnanimous questionnaire was negatively correlated with \" Psychological\" and \" Yield\" dimension of the cancer heart state questionnaire(r=-0.279, -0.285, P<0.05), and positively correlated with \" Facing\" of the cancer response questionnaire, \" Good physical condition and ability\" and \" Psychological well-being\" dimension of the cancer patient's life function index scale(r=0.367, 0.402, 0.379, P<0.05). There was a negative correlation between the \" enterprising\" dimension of the magnanimous questionnaire and the beta wave value in individual group. \u0000 \u0000 \u0000Conclusion \u0000The magnanimous therapy can improve enterprising and magnanimous level of patients with lung cancer, and the effects are related with the above-mentioned psychosomatic factors. \u0000 \u0000 \u0000Key words: \u0000Magnanimous therapy; Enterprising and magnanimous psychology; Lung cancer patients; Efficacy; Related factors","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"29 1","pages":"27-32"},"PeriodicalIF":0.0,"publicationDate":"2020-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48627833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-20DOI: 10.3760/CMA.J.CN371468-20190417-00261
N. Zhao, Zhu Chen, Peng Wang, Fang Li
Objective To study the relationship between Helicobacter pylori (HP) infection and homocysteine (Hcy) levels and cerebral small vessel disease (CSVD). Methods From March 2017 to December 2018, 67 patients (outpatient and inpatient) who complained of dizziness in the First Affiliated Hospital of Jinzhou Medical University were divided into CSVD group(30 cases) and control group(37 cases). Single factor analysis, Spearman correlation analysis and binary logistic regression analysis were used to analyze the influencing factors of CSVD.Receiver operating characteristic curve was used to predict the diagnostic value of influencing factors for CSVD.The effects of HP and Hcy on CSVD were analyzed using mediation effect. Results (1)Hcy (r=0.345, P=0.004), HP positive (r=0.274, P=0.026), age (r=0.420, P=0.000), male (r=0.260, P=0.034), total cholesterol (r=0.273, P=0.025), triglycerides (r=0.272, P=0.026), hypertension (r=0.454, P=0.000), diabetes (r=0.284, P=0.020), smoking (r=0.499, P=0.000), coronary heart disease (r=0.284, P=0.020) were positively correlated with CSVD.(2)Logistic regression analysis showed that Hcy (β=0.315, OR=1.370, 95%CI=1.025-1.831), total cholesterol (β=0.979, OR=2.661, 95%CI=1.086-6.523) were independent risk factors for CSVD.(3)Hcy (sensitivity: 76.7%, specificity: 86.5%)and total cholesterol levels(sensitivity: 90.0%, specificity: 83.8%) had specific and sensitive diagnostic value for the diagnosis of CSVD, and total cholesterol (area under ROC curve=0.928) had more diagnostic value than Hcy (area under ROC curve=0.877). (4) The mediating effect of HP on CSVD was not completely affected by the mediating effect of Hcy, and HP had partially direct effect on CSVD. Conclusions (1) Hcy and total cholesterol are independent risk factors of CSVD, which have specific and sensitive diagnostic value for CSVD, especially for total cholesterol.(2)The mediating effect of HP on CSVD is not completely affected by the mediating variable Hcy, and HP has a partially direct effect on CSVD. Key words: Cerebral small vessel disease; Risk factors; Homocysteine; Helicobacter pylori
{"title":"Correlation between Helicobacter pylori infection and homocysteine levels and cerebral small vessel disease","authors":"N. Zhao, Zhu Chen, Peng Wang, Fang Li","doi":"10.3760/CMA.J.CN371468-20190417-00261","DOIUrl":"https://doi.org/10.3760/CMA.J.CN371468-20190417-00261","url":null,"abstract":"Objective \u0000To study the relationship between Helicobacter pylori (HP) infection and homocysteine (Hcy) levels and cerebral small vessel disease (CSVD). \u0000 \u0000 \u0000Methods \u0000From March 2017 to December 2018, 67 patients (outpatient and inpatient) who complained of dizziness in the First Affiliated Hospital of Jinzhou Medical University were divided into CSVD group(30 cases) and control group(37 cases). Single factor analysis, Spearman correlation analysis and binary logistic regression analysis were used to analyze the influencing factors of CSVD.Receiver operating characteristic curve was used to predict the diagnostic value of influencing factors for CSVD.The effects of HP and Hcy on CSVD were analyzed using mediation effect. \u0000 \u0000 \u0000Results \u0000(1)Hcy (r=0.345, P=0.004), HP positive (r=0.274, P=0.026), age (r=0.420, P=0.000), male (r=0.260, P=0.034), total cholesterol (r=0.273, P=0.025), triglycerides (r=0.272, P=0.026), hypertension (r=0.454, P=0.000), diabetes (r=0.284, P=0.020), smoking (r=0.499, P=0.000), coronary heart disease (r=0.284, P=0.020) were positively correlated with CSVD.(2)Logistic regression analysis showed that Hcy (β=0.315, OR=1.370, 95%CI=1.025-1.831), total cholesterol (β=0.979, OR=2.661, 95%CI=1.086-6.523) were independent risk factors for CSVD.(3)Hcy (sensitivity: 76.7%, specificity: 86.5%)and total cholesterol levels(sensitivity: 90.0%, specificity: 83.8%) had specific and sensitive diagnostic value for the diagnosis of CSVD, and total cholesterol (area under ROC curve=0.928) had more diagnostic value than Hcy (area under ROC curve=0.877). (4) The mediating effect of HP on CSVD was not completely affected by the mediating effect of Hcy, and HP had partially direct effect on CSVD. \u0000 \u0000 \u0000Conclusions \u0000(1) Hcy and total cholesterol are independent risk factors of CSVD, which have specific and sensitive diagnostic value for CSVD, especially for total cholesterol.(2)The mediating effect of HP on CSVD is not completely affected by the mediating variable Hcy, and HP has a partially direct effect on CSVD. \u0000 \u0000 \u0000Key words: \u0000Cerebral small vessel disease; Risk factors; Homocysteine; Helicobacter pylori","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"29 1","pages":"50-55"},"PeriodicalIF":0.0,"publicationDate":"2020-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45673436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective To investigate the correlation between fluid-attenuated inversion recovery vascular hyperintensities(FVH) and prognosis and cognitive dysfunction in patients with internal watershed cerebral infarction(IWI). Methods Totally106 patients with IWI were selected.According to FVH diagnostic criteria, there were 59 cases in FVH (+ ) group and 47 cases in FVH (-) group.Demographic data and risk factors of cerebrovascular disease were collected to assess the clinical neurological function of the patients at admission and discharge, and the short-term outcome was assessed by modified RANKIN scale (mRS) score at 90 days after discharge.The cognitive function of patients was assessed by MMSE scale. Results There was no significant difference in NIHSS score between the two groups on admission (P>0.05). The NIHSS score of FVH (+ ) group((3.37±2.33))at discharge was significantly lower than that of the FVH (-) group ((4.43±2.72))(P 0.05). Conclusion FVH has no correlation with the severity of IWI patients when they are admitted to hospital.FVH may be used as an imaging sign for prognosis evaluation of patients with IWI .However, IWI patients with FVH may have more severe cognitive impairment. Key words: Fluid-attenuated inversion recovery vascular hyperintensities; Internal watershed infarction; Prognosis; Cognitive impairment
{"title":"Correlation between fluid-attenuated inversion recovery vascular hyperintensities and prognosis and cognitive dysfunction in patients with internal watershed cerebral infarction","authors":"Zhenbao Liu, Weixia Yang, Yulong Jiang, Wei-wen Wu","doi":"10.3760/CMA.J.CN371468-20190907-00611","DOIUrl":"https://doi.org/10.3760/CMA.J.CN371468-20190907-00611","url":null,"abstract":"Objective \u0000To investigate the correlation between fluid-attenuated inversion recovery vascular hyperintensities(FVH) and prognosis and cognitive dysfunction in patients with internal watershed cerebral infarction(IWI). \u0000 \u0000 \u0000Methods \u0000Totally106 patients with IWI were selected.According to FVH diagnostic criteria, there were 59 cases in FVH (+ ) group and 47 cases in FVH (-) group.Demographic data and risk factors of cerebrovascular disease were collected to assess the clinical neurological function of the patients at admission and discharge, and the short-term outcome was assessed by modified RANKIN scale (mRS) score at 90 days after discharge.The cognitive function of patients was assessed by MMSE scale. \u0000 \u0000 \u0000Results \u0000There was no significant difference in NIHSS score between the two groups on admission (P>0.05). The NIHSS score of FVH (+ ) group((3.37±2.33))at discharge was significantly lower than that of the FVH (-) group ((4.43±2.72))(P 0.05). \u0000 \u0000 \u0000Conclusion \u0000FVH has no correlation with the severity of IWI patients when they are admitted to hospital.FVH may be used as an imaging sign for prognosis evaluation of patients with IWI .However, IWI patients with FVH may have more severe cognitive impairment. \u0000 \u0000 \u0000Key words: \u0000Fluid-attenuated inversion recovery vascular hyperintensities; Internal watershed infarction; Prognosis; Cognitive impairment","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"29 1","pages":"66-69"},"PeriodicalIF":0.0,"publicationDate":"2020-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70011350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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