Pub Date : 2020-02-20DOI: 10.3760/CMA.J.CN371468-20190916-00622
Han Yan, Yun Chen, Hongfei Ma, N. Xie, Xia Wang, Stacey B. Daughters, M. Chawarski, Wang Zhou
Objective To evaluate the reliability and validity of the Reward Probability Index-Chinese version (C-RPI) among individuals with opioid dependence. Methods A total of 160 individuals with opioid dependence were recruited from the methadone maintenance treatment(MMT) programs in Wuhan.The C-RPI was used in the investigation, and items/exploratory factors and confirmatory factors were adopted to analyze with IBM SPSS 22.0 and AMOS 24.0, respectively. Results The correlation between each item and the total score of the scale was 0.325-0.657 (all P<0.01) and the item discrimination of the scale was good.Exploratory factor analysis extracted two factors, including reward probability and environmental suppressors, and a load of each item on its factor ranged from 0.519 to 0.744.The fitting indexes of confirmatory factor analysis were as follows: χ2/df=1.623, RMR=0.030, RMSEA=0.063, IFI=0.902, TLI=0.885, CFI =0.900.The internal consistency coefficient (Cronbach's α) of the C-RPI was 0.800; and there was no ceiling/floor effect on each dimension and total scale. Conclusion The classification of dimensions for the C-RPI is reasonable, and the scale has good reliability and validity to measure the ability to obtain environmental rewards for individuals with opioid dependence. Key words: Reward probability index (RPI); Reliability; Validity; Opioid dependence
{"title":"The reliability and validity of Reward Probability Index-Chinese version applied among individuals with opioid dependence","authors":"Han Yan, Yun Chen, Hongfei Ma, N. Xie, Xia Wang, Stacey B. Daughters, M. Chawarski, Wang Zhou","doi":"10.3760/CMA.J.CN371468-20190916-00622","DOIUrl":"https://doi.org/10.3760/CMA.J.CN371468-20190916-00622","url":null,"abstract":"Objective \u0000To evaluate the reliability and validity of the Reward Probability Index-Chinese version (C-RPI) among individuals with opioid dependence. \u0000 \u0000 \u0000Methods \u0000A total of 160 individuals with opioid dependence were recruited from the methadone maintenance treatment(MMT) programs in Wuhan.The C-RPI was used in the investigation, and items/exploratory factors and confirmatory factors were adopted to analyze with IBM SPSS 22.0 and AMOS 24.0, respectively. \u0000 \u0000 \u0000Results \u0000The correlation between each item and the total score of the scale was 0.325-0.657 (all P<0.01) and the item discrimination of the scale was good.Exploratory factor analysis extracted two factors, including reward probability and environmental suppressors, and a load of each item on its factor ranged from 0.519 to 0.744.The fitting indexes of confirmatory factor analysis were as follows: χ2/df=1.623, RMR=0.030, RMSEA=0.063, IFI=0.902, TLI=0.885, CFI =0.900.The internal consistency coefficient (Cronbach's α) of the C-RPI was 0.800; and there was no ceiling/floor effect on each dimension and total scale. \u0000 \u0000 \u0000Conclusion \u0000The classification of dimensions for the C-RPI is reasonable, and the scale has good reliability and validity to measure the ability to obtain environmental rewards for individuals with opioid dependence. \u0000 \u0000 \u0000Key words: \u0000Reward probability index (RPI); Reliability; Validity; Opioid dependence","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"29 1","pages":"172-176"},"PeriodicalIF":0.0,"publicationDate":"2020-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48080993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective To study whether aspirin has inhibitory effect on microglia activation induced by Poly-IC and its mechanism. Methods Microglia cell line BV2 were cultured in vitro to establish a Poly-IC stimulation-induced microglia cell immune activation model. The experiment groups were divided into control group (no treatment), model group (Poly-IC 10 μg/ml), high dose aspirin group (1 mmol/L aspirin), low dose aspirin group (0.1 mmol/L aspirin), high dose aspirin pretreatment group (Poly-IC 10 μg/ml + 1 mmol/L aspirin) and low dose aspirin pretreatment group (Poly-IC 10 μg/ml + 0.1 mmol/L aspirin). The phagocytosis ability of microglia cells, reactive oxygen species (ROS) and Iba1 protein expression were detected by using immunofluorescence method. The expression of the inflammatory cytokines Il-1β, Il-6, Il-10, TNF-α and cox-2 mRNA in microglia cells were detected by real-time quantitative PCR (RT-qPCR). Results Compared with the control group, the morphology of microglia cells in model group changed significantly, and the phagocytosis ability and production of reactive oxygen species (ROS) increased. At the meantime, the expression of Iba1 protein was strongly decreased. In the model group, The mRNA expressions of IL-1β(20.55±1.92), IL-6 (63.98±7.83), TNF-α (16.84±3.19), COX-2 (6.78±0.42) were higher than IL-1β(1.01±0.14), IL-6 (0.95±0.17), TNF-α (1.22±0.38), COX-2 (0.87±0.11) in the control group. (Il-1β (t=26.14), Il-6 (t=10.22), TNF-α (t=17.06) and COX-2 (t=37.07), all P<0.01). In the aspirin pretreatment group, the phagocytic ability of microglia cells was inhibited compared with the model group, and the production of reactive oxygen species (ROS) reduced. The expression of Iba1 protein was also partly recovered. Meanwhile, the effect of the high aspirin dose pretreatment group on pro-inflammatory factors IL-1β(9.95±0.52), IL-6 (39.64±6.89), TNF-α(1.57±0.42), COX-2 (2.47±0.14)were lower than those in the model group significantly.(IL-1β: t=14.18, IL-6: t=3.69, TNF-α: t=16.68, COX-2: t=27.03, all P<0.01). Conclusion Aspirin has an inhibitory effect on microglial activation induced by Poly-IC, which may be related with inhibiting the expression of inflammatory factors. Key words: Microglia cells; Poly-IC; Aspirin; Infection during pregnancy; Maternal immune activation
{"title":"Effect of aspirin on microglia activation induced by Poly-IC and its regulatory mechanism","authors":"Haojuan Wu, Juan Cheng, Jiang Xie, Jiamin Li, Hua Li, Hua Zhu, Hongxia Li, Yongmei Zhou, Wenming Xu, Xu-Lin Jia","doi":"10.3760/CMA.J.CN371468-20190830-00596","DOIUrl":"https://doi.org/10.3760/CMA.J.CN371468-20190830-00596","url":null,"abstract":"Objective \u0000To study whether aspirin has inhibitory effect on microglia activation induced by Poly-IC and its mechanism. \u0000 \u0000 \u0000Methods \u0000Microglia cell line BV2 were cultured in vitro to establish a Poly-IC stimulation-induced microglia cell immune activation model. The experiment groups were divided into control group (no treatment), model group (Poly-IC 10 μg/ml), high dose aspirin group (1 mmol/L aspirin), low dose aspirin group (0.1 mmol/L aspirin), high dose aspirin pretreatment group (Poly-IC 10 μg/ml + 1 mmol/L aspirin) and low dose aspirin pretreatment group (Poly-IC 10 μg/ml + 0.1 mmol/L aspirin). The phagocytosis ability of microglia cells, reactive oxygen species (ROS) and Iba1 protein expression were detected by using immunofluorescence method. The expression of the inflammatory cytokines Il-1β, Il-6, Il-10, TNF-α and cox-2 mRNA in microglia cells were detected by real-time quantitative PCR (RT-qPCR). \u0000 \u0000 \u0000Results \u0000Compared with the control group, the morphology of microglia cells in model group changed significantly, and the phagocytosis ability and production of reactive oxygen species (ROS) increased. At the meantime, the expression of Iba1 protein was strongly decreased. In the model group, The mRNA expressions of IL-1β(20.55±1.92), IL-6 (63.98±7.83), TNF-α (16.84±3.19), COX-2 (6.78±0.42) were higher than IL-1β(1.01±0.14), IL-6 (0.95±0.17), TNF-α (1.22±0.38), COX-2 (0.87±0.11) in the control group. (Il-1β (t=26.14), Il-6 (t=10.22), TNF-α (t=17.06) and COX-2 (t=37.07), all P<0.01). In the aspirin pretreatment group, the phagocytic ability of microglia cells was inhibited compared with the model group, and the production of reactive oxygen species (ROS) reduced. The expression of Iba1 protein was also partly recovered. Meanwhile, the effect of the high aspirin dose pretreatment group on pro-inflammatory factors IL-1β(9.95±0.52), IL-6 (39.64±6.89), TNF-α(1.57±0.42), COX-2 (2.47±0.14)were lower than those in the model group significantly.(IL-1β: t=14.18, IL-6: t=3.69, TNF-α: t=16.68, COX-2: t=27.03, all P<0.01). \u0000 \u0000 \u0000Conclusion \u0000Aspirin has an inhibitory effect on microglial activation induced by Poly-IC, which may be related with inhibiting the expression of inflammatory factors. \u0000 \u0000 \u0000Key words: \u0000Microglia cells; Poly-IC; Aspirin; Infection during pregnancy; Maternal immune activation","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"29 1","pages":"114-119"},"PeriodicalIF":0.0,"publicationDate":"2020-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49416511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective To explore the significance of empathy and executive function indexes in the diagnosis and classification of autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD). Methods According to DSM-Ⅴ diagnostic criteria, 33 children with ASD, 30 children with ADHD and 39 typical development (TD) children and adolescents were enrolled as the research subjects.The empathy and executive function characteristics were compared and analyzed in the subjects.Based on empathy and executive function indicators, the three groups of subjects were diagnosed and classified by machine learning method. Results The total score of Griffith empathy measure parent ratings(GEM-PR)(ASD: (0.67±0.64), ADHD: (1.00±0.79), TD: (0.98±0.73)) and each factor score (F=3.595-10.363, all P<0.05) and the total score of behavior rating inventory of executive function(BRIEF)(ASD: (62.79±7.45), ADHD: (59.47±8.77), TD: (49.08±7.91)) and each factor score of the three groups were different (F=6.557-33.205, all P<0.01). Among them, the scores of empathy and executive function in ASD and ADHD groups were generally higher than those in TD children (all P<0.05). When combined with BRIEF scale and GEM scale, the classification accuracy of the three groups reached 62.75%. Conclusion Both ASD and ADHD children have damages in empathy and executive function.Combining empathy and executive function indexes are more helpful for diagnosis and classification than single index. Key words: Autism spectrum disorder; Attention deficit hyperactivity disorder; Empathy; Executive function; Diagnosis and classification
{"title":"Diagnosis and classification of high-functional autism spectrum disorder and attention deficit hyperactivity disorder by combining empathy and executive function","authors":"Yue Wang, Yun Li, Yao Wang, Chunyan Li, Linyan Fu, Peiying Jin, Mengyao Zhai, Xin Cheng, Xiwen Cui, Jiying Jiang, T. Xiao","doi":"10.3760/CMA.J.CN371468-20191008-00717","DOIUrl":"https://doi.org/10.3760/CMA.J.CN371468-20191008-00717","url":null,"abstract":"Objective \u0000To explore the significance of empathy and executive function indexes in the diagnosis and classification of autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD). \u0000 \u0000 \u0000Methods \u0000According to DSM-Ⅴ diagnostic criteria, 33 children with ASD, 30 children with ADHD and 39 typical development (TD) children and adolescents were enrolled as the research subjects.The empathy and executive function characteristics were compared and analyzed in the subjects.Based on empathy and executive function indicators, the three groups of subjects were diagnosed and classified by machine learning method. \u0000 \u0000 \u0000Results \u0000The total score of Griffith empathy measure parent ratings(GEM-PR)(ASD: (0.67±0.64), ADHD: (1.00±0.79), TD: (0.98±0.73)) and each factor score (F=3.595-10.363, all P<0.05) and the total score of behavior rating inventory of executive function(BRIEF)(ASD: (62.79±7.45), ADHD: (59.47±8.77), TD: (49.08±7.91)) and each factor score of the three groups were different (F=6.557-33.205, all P<0.01). Among them, the scores of empathy and executive function in ASD and ADHD groups were generally higher than those in TD children (all P<0.05). When combined with BRIEF scale and GEM scale, the classification accuracy of the three groups reached 62.75%. \u0000 \u0000 \u0000Conclusion \u0000Both ASD and ADHD children have damages in empathy and executive function.Combining empathy and executive function indexes are more helpful for diagnosis and classification than single index. \u0000 \u0000 \u0000Key words: \u0000Autism spectrum disorder; Attention deficit hyperactivity disorder; Empathy; Executive function; Diagnosis and classification","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"29 1","pages":"120-124"},"PeriodicalIF":0.0,"publicationDate":"2020-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41531765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-20DOI: 10.3760/CMA.J.CN371468-20191023-00769
Yi-xin Chen, Yang Zhou, R. Gao, Tu-nong Chen, Jianjun Wang, Juan Cao, Yiyang Huang
Objective To explore the improvement of core symptoms in children with autism whose auditory pathway dysfunction were repaired after accepting auditory integration training(AIT). Methods The ASD children with abnormal auditory evoked potentials were divided into AIT group (the ones whose BAEP return to normal after AIT training into test group), control group A (blank control group) and control group B (ABA training group). The ASD children were assessed by Portage Development Checklist, Child Autism Rating Scale (CARS) and Autism Therapy Assessment Scale (ATEC) at the time of admission, one month after admission, three months after admission.The curative effect with the change value of each factor fraction was evaluated. Results At the time of enrollment, there were no significant differences among the scores of CARS((36.31±4.08), (36.33±3.76), (36.33±5.14)) as well as ATEC language ((19.08±6.43), (16.40±6.42), (18.48±5.96)), social ((15.63±7.13), (16.05±7.57), (16.19±7.19)), and perception ((16.78±5.39) (16.92±6.75), (17.12±6.73)) and self-care ((15.98±8.71), (17.93±8.22), (17.26±8.93), respectively)) in the AIT group, control group B and control group A. After one month and three months from enrollment, the scores of CARS were ((33.96±3.79), (35.09±4.38) and (34.30±3.98), respectively after one month; (32.95±3.15), (36.86±3.86) and (33.95±3.90), respectively) after three months in the AIT group, control group B and control group A. The repeated measurement analysis of variance showed that the main effect of time was significant (F=22.308, P 0.05), and there was interaction between time and group (F= 8.626, P 0.05). Multiple comparisons showed that the scores of ATEC self-care ability scale between the AIT group and the control group A were statistically significant (I-J=-4.46, P<0.05). Conclusion The results of this study show that AIT training can improve the core symptoms of the ASD children whose BAEP returns to normal. Key words: Autism spectrum disorder; Auditory integration training; Brainstem auditory evoked potential; Effects
目的探讨接受听觉整合训练（AIT）后听觉通路功能障碍得到修复的自闭症儿童核心症状的改善。方法将听觉诱发电位异常的ASD患儿分为AIT组（AIT训练后BAEP恢复正常者分为试验组）、对照组A（空白对照组）和对照组B（ABA训练组）。在入院时、入院后1个月、入院后3个月采用Portage Development Checklist、Child Autism Rating Scale（CARS）和Autism Therapy Assessment Scale（ATEC）对ASD儿童进行评估。评价疗效与各因子组分的变化值。结果在入学时，CARS（（36.31±4.08）、（36.33±3.76）、（3.633±5.14））、ATEC语言（（19.08±6.43）、（16.40±6.42）、（18.48±5.96））、社会（（15.63±7.13）、17.26±8.93），AIT组、对照组B和对照组A的CARS评分分别为（33.96±3.79）、（35.09±4.38）和（34.30±3.98）；AIT组、对照组B和对照组A在3个月后分别为（32.95±3.15）、（36.86±3.86）和（33.95±3.90），AIT组与对照组A的ATEC自理能力量表得分有统计学意义（I-J=4.46，P<0.05）。结论AIT训练可改善BAEP恢复正常的ASD患儿的核心症状。关键词：自闭症谱系障碍；听觉整合训练；脑干听觉诱发电位；效果
{"title":"Effect of auditory integration training on core symptoms in children with autism spectrum disorders whose auditory conduction dysfunction repaired","authors":"Yi-xin Chen, Yang Zhou, R. Gao, Tu-nong Chen, Jianjun Wang, Juan Cao, Yiyang Huang","doi":"10.3760/CMA.J.CN371468-20191023-00769","DOIUrl":"https://doi.org/10.3760/CMA.J.CN371468-20191023-00769","url":null,"abstract":"Objective \u0000To explore the improvement of core symptoms in children with autism whose auditory pathway dysfunction were repaired after accepting auditory integration training(AIT). \u0000 \u0000 \u0000Methods \u0000The ASD children with abnormal auditory evoked potentials were divided into AIT group (the ones whose BAEP return to normal after AIT training into test group), control group A (blank control group) and control group B (ABA training group). The ASD children were assessed by Portage Development Checklist, Child Autism Rating Scale (CARS) and Autism Therapy Assessment Scale (ATEC) at the time of admission, one month after admission, three months after admission.The curative effect with the change value of each factor fraction was evaluated. \u0000 \u0000 \u0000Results \u0000At the time of enrollment, there were no significant differences among the scores of CARS((36.31±4.08), (36.33±3.76), (36.33±5.14)) as well as ATEC language ((19.08±6.43), (16.40±6.42), (18.48±5.96)), social ((15.63±7.13), (16.05±7.57), (16.19±7.19)), and perception ((16.78±5.39) (16.92±6.75), (17.12±6.73)) and self-care ((15.98±8.71), (17.93±8.22), (17.26±8.93), respectively)) in the AIT group, control group B and control group A. After one month and three months from enrollment, the scores of CARS were ((33.96±3.79), (35.09±4.38) and (34.30±3.98), respectively after one month; (32.95±3.15), (36.86±3.86) and (33.95±3.90), respectively) after three months in the AIT group, control group B and control group A. The repeated measurement analysis of variance showed that the main effect of time was significant (F=22.308, P 0.05), and there was interaction between time and group (F= 8.626, P 0.05). Multiple comparisons showed that the scores of ATEC self-care ability scale between the AIT group and the control group A were statistically significant (I-J=-4.46, P<0.05). \u0000 \u0000 \u0000Conclusion \u0000The results of this study show that AIT training can improve the core symptoms of the ASD children whose BAEP returns to normal. \u0000 \u0000 \u0000Key words: \u0000Autism spectrum disorder; Auditory integration training; Brainstem auditory evoked potential; Effects","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"29 1","pages":"142-147"},"PeriodicalIF":0.0,"publicationDate":"2020-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47634931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-20DOI: 10.3760/CMA.J.CN371468-20190704-00446
Ying Su, F. Guo, Zhiyan Chen
Objective To identify the influencing factors of maternal anxiety, and explore the moderating role of co-parenting in the effect of marriage quality on maternal anxiety. Methods Totally 522 mothers with children aged 0-12 were enrolled in the surveys and completed the Generalized Anxiety Disorder (GAD-7), Marital Adjustment Test and Co-parenting Relationship Scale.The chi-square test, the spearman correlation analysis and non-parametric percentile Bootstrap method were processed by SPSS 22.0. Results ①The detection rate of anxiety in the mothers was 48.7%, and the rate for mild, moderate, and severe anxiety was 37.4%, 8.4%, 2.9%, respectively.② The chi-square test showed that the family factors, such as mother's age, level of workload, family economic conditions, husband's level of workload, the child's age and health condition, as well as the conflicts between parents and grandparents and the grandparents’ willingness of involving in raising children, significantly affected mother’s anxiety(χ2=4.292-23.170, P<0.05). ②The maternal anxiety was negatively correlated with marital quality (r=-0.419, P<0.01). ③ Both positive co-parenting (PCP) and negative co-parenting(NCP) played moderating roles in the relationship between marriage quality and maternal anxiety(BPCP=0.013, P<0.01; BNCP=-0.010, P<0.05). Conclusion Marital quality is an important factor which affects maternal anxiety, and father’s performance in co-parenting plays a moderating role in it. Key words: Maternal anxiety; Marriage quality; Co-parenting; Moderation
{"title":"The moderating role of co-parenting between marriage quality and maternal anxiety","authors":"Ying Su, F. Guo, Zhiyan Chen","doi":"10.3760/CMA.J.CN371468-20190704-00446","DOIUrl":"https://doi.org/10.3760/CMA.J.CN371468-20190704-00446","url":null,"abstract":"Objective \u0000To identify the influencing factors of maternal anxiety, and explore the moderating role of co-parenting in the effect of marriage quality on maternal anxiety. \u0000 \u0000 \u0000Methods \u0000Totally 522 mothers with children aged 0-12 were enrolled in the surveys and completed the Generalized Anxiety Disorder (GAD-7), Marital Adjustment Test and Co-parenting Relationship Scale.The chi-square test, the spearman correlation analysis and non-parametric percentile Bootstrap method were processed by SPSS 22.0. \u0000 \u0000 \u0000Results \u0000①The detection rate of anxiety in the mothers was 48.7%, and the rate for mild, moderate, and severe anxiety was 37.4%, 8.4%, 2.9%, respectively.② The chi-square test showed that the family factors, such as mother's age, level of workload, family economic conditions, husband's level of workload, the child's age and health condition, as well as the conflicts between parents and grandparents and the grandparents’ willingness of involving in raising children, significantly affected mother’s anxiety(χ2=4.292-23.170, P<0.05). ②The maternal anxiety was negatively correlated with marital quality (r=-0.419, P<0.01). ③ Both positive co-parenting (PCP) and negative co-parenting(NCP) played moderating roles in the relationship between marriage quality and maternal anxiety(BPCP=0.013, P<0.01; BNCP=-0.010, P<0.05). \u0000 \u0000 \u0000Conclusion \u0000Marital quality is an important factor which affects maternal anxiety, and father’s performance in co-parenting plays a moderating role in it. \u0000 \u0000 \u0000Key words: \u0000Maternal anxiety; Marriage quality; Co-parenting; Moderation","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"29 1","pages":"153-158"},"PeriodicalIF":0.0,"publicationDate":"2020-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41517364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-20DOI: 10.3760/CMA.J.CN371468-20190916-00633
Li Peng, Xiang Zhang, Zhongming Li, Wei Fan, Xing Liu, Xiaohan Wei, Jie Deng
Objective To explore the effects of gaseous formaldehyde exposure on male Sprague-Dawley rat brain function and synaptic protein expression, as well as the neuroprotective effects of resveratrol. Methods Eighty-four male Sprague-Dawley rats were randomly divided into seven group with 12 in each group: control group (N), gaseous formaldehyde accumulation low concentration group (FL group), gaseous formaldehyde accumulation medium concentration group (FM group), gaseous formaldehyde accumulation high concentration group (FH group), gaseous formaldehyde accumulation low concentration + resveratrol group (FLR group), gaseous formaldehyde accumulation concentration + resveratrol group (FMR group) and gaseous formaldehyde accumulation high concentration + resveratrol group (FHR group). The animal model of gaseous formaldehyde accumulation was established by gas formaldehyde exposure method.Learning and memory function was tested by Morris water maze. Cortical and hippocampal neurogranin (Ng) protein expression in brain cortex and hippocampus was measured by Western blot. Results (1) Compared with the escape latency and original platform retention time of rats in group N ((19.75±4.08) s, (43.47±2.43) s), the escape latency of rats in FM and FH groups was prolonged ((25.52±2.98) s, (27.45±2.39) s, t=-4.97, -5.82; both P<0.01), the retention time of the original platform was shortened ((30.99±4.21) s, (18.70±2.58) s, t=10.24, 25.71; both P<0.01). Compared with the corresponding formaldehyde accumulation groups such as the FM and FH groups, the escape latency of the rats in the FMR and FHR groups was significantly longer ((21.37±3.80) s, (24.26±3.56) s, t=1.86, 3.93; both P<0.05), the retention time of the original platform was significantly prolonged ((40.33±3.63)s, (23.46±4.73)s, t=-7.50, -3.95; both P<0.01). (2) Compared with the expression of Ng in cortex and hippocampus of rats in group N ((0.99±0.03), (1.07±0.03)), the expression of Ng protein in cortex and hippocampus of rats in FM and FH groups was significantly reduced((0.62±0.06), (0.39±0.03), (0.77±0.09), (0.46±0.10), t=11.55, 14.08, 11.51, 13.17; all P<0.01). Compared with the corresponding formaldehyde accumulation groups such as the FM and FH groups, the expressions of Ng in the cortex and hippocampus of the rats in the FMR and FHR groups were significantly increased ((0.94±0.11), (0.48±0.04), (0.95±0.05), (0.60±0.09), t=-5.26, -2.09, -5.32, -2.21; all P<0.05). Conclusion Resveratrol can improve the learning and memory function of rats caused by the accumulation of gaseous formaldehyde.The mechanism may be related with the upregulation of Ng. Key words: Gaseous formaldehyde accumulation; Neurogranin; Learning and memory; Resveratrol; Rat
{"title":"Resveratrol prevents brain injury and neurogranin expression in rats exposed to gaseous formaldehyde","authors":"Li Peng, Xiang Zhang, Zhongming Li, Wei Fan, Xing Liu, Xiaohan Wei, Jie Deng","doi":"10.3760/CMA.J.CN371468-20190916-00633","DOIUrl":"https://doi.org/10.3760/CMA.J.CN371468-20190916-00633","url":null,"abstract":"Objective \u0000To explore the effects of gaseous formaldehyde exposure on male Sprague-Dawley rat brain function and synaptic protein expression, as well as the neuroprotective effects of resveratrol. \u0000 \u0000 \u0000Methods \u0000Eighty-four male Sprague-Dawley rats were randomly divided into seven group with 12 in each group: control group (N), gaseous formaldehyde accumulation low concentration group (FL group), gaseous formaldehyde accumulation medium concentration group (FM group), gaseous formaldehyde accumulation high concentration group (FH group), gaseous formaldehyde accumulation low concentration + resveratrol group (FLR group), gaseous formaldehyde accumulation concentration + resveratrol group (FMR group) and gaseous formaldehyde accumulation high concentration + resveratrol group (FHR group). The animal model of gaseous formaldehyde accumulation was established by gas formaldehyde exposure method.Learning and memory function was tested by Morris water maze. Cortical and hippocampal neurogranin (Ng) protein expression in brain cortex and hippocampus was measured by Western blot. \u0000 \u0000 \u0000Results \u0000(1) Compared with the escape latency and original platform retention time of rats in group N ((19.75±4.08) s, (43.47±2.43) s), the escape latency of rats in FM and FH groups was prolonged ((25.52±2.98) s, (27.45±2.39) s, t=-4.97, -5.82; both P<0.01), the retention time of the original platform was shortened ((30.99±4.21) s, (18.70±2.58) s, t=10.24, 25.71; both P<0.01). Compared with the corresponding formaldehyde accumulation groups such as the FM and FH groups, the escape latency of the rats in the FMR and FHR groups was significantly longer ((21.37±3.80) s, (24.26±3.56) s, t=1.86, 3.93; both P<0.05), the retention time of the original platform was significantly prolonged ((40.33±3.63)s, (23.46±4.73)s, t=-7.50, -3.95; both P<0.01). (2) Compared with the expression of Ng in cortex and hippocampus of rats in group N ((0.99±0.03), (1.07±0.03)), the expression of Ng protein in cortex and hippocampus of rats in FM and FH groups was significantly reduced((0.62±0.06), (0.39±0.03), (0.77±0.09), (0.46±0.10), t=11.55, 14.08, 11.51, 13.17; all P<0.01). Compared with the corresponding formaldehyde accumulation groups such as the FM and FH groups, the expressions of Ng in the cortex and hippocampus of the rats in the FMR and FHR groups were significantly increased ((0.94±0.11), (0.48±0.04), (0.95±0.05), (0.60±0.09), t=-5.26, -2.09, -5.32, -2.21; all P<0.05). \u0000 \u0000 \u0000Conclusion \u0000Resveratrol can improve the learning and memory function of rats caused by the accumulation of gaseous formaldehyde.The mechanism may be related with the upregulation of Ng. \u0000 \u0000 \u0000Key words: \u0000Gaseous formaldehyde accumulation; Neurogranin; Learning and memory; Resveratrol; Rat","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"29 1","pages":"97-101"},"PeriodicalIF":0.0,"publicationDate":"2020-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44098311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-20DOI: 10.3760/CMA.J.CN371468-20190924-00618
Zi-yang Ji, Yan Li, Jing-yang Gu, H. Jin, Jiao Dong, Xiao-li Zhang, Chang-Hong Wang
Objective To explore the effect of cognitive behavior orientation group psychotherapy on coping style, time management and family function of middle school students with internet addiction, and provide theoretical basis for the internet addiction psychotherapy system. Methods Based on IAT, 70 internet addiction middle school students were screened and divided into control group and experimental group according to random number table method.The control group was only given conventionally psychological and drug treatments, the experimental group participated in cognitive behavioral orientation group psychotherapy on the basis of the treatment of the control group.Thirty-two people in the control group and thirty-three people in the experimental group completed the treatment.Before and after treatment, the two groups of middle school students were evaluated by the internet IAT, the SCSQ, the ATMD and the FAD. Results There was no significant difference in the scales between the two groups of internet addiction middle school students before treatment (all P>0.05). After the intervention of the experimental group, the differences in the positive response (1.89±0.51), negative response (1.55±0.51), time monitoring (58.39±12.10), time value (26.64±4.48), time efficacy (30.42±5.18), and roles(18.85±2.40), communication(24.18±3.77), behavior control (18.82±2.57) and general functioning(24.79±3.90) of FAD were statistically significant compared with the control group (1.62±0.44), (1.84±0.55), (52.09±11.72), (19.34±3.96), (21.91±6.13), (21.16±2.63), (26.09±3.75), (20.59±2.54), (28.69±3.68) and the pre-intervention period (1.46±0.48), (1.97±0.56), (48.73±13.46), (18.27±4.84), (20.00±5.79), (21.76±2.72), (26.58±3.86), (19.76±2.96), (29.27±4.76) (all P<0.05). There were significant differences in problem-solving (12.67±2.50) and affective responsiveness (14.03±3.73) scores of the FAD between the experimental group and the pre-intervention group (14.15±2.83), (14.61±3.66) (all P<0.05). There were significant differences in SCSQ and ATMD before and after treatment in the control group (all P<0.05). Conclusion Cognitive behavior orientation group psychotherapy can optimize the coping style, ameliorate their time management ability and significantly improve the role, communication, behavior control and overall function of family function of middle school students with internet addiction. Key words: Cognitive behavior therapy; Group psychotherapy; Middle school student; Internet addiction; Coping style; Time management; Family function
{"title":"Effect of cognitive behavior orientation group psychotherapy on coping style, time management and family function of middle school students with internet addiction","authors":"Zi-yang Ji, Yan Li, Jing-yang Gu, H. Jin, Jiao Dong, Xiao-li Zhang, Chang-Hong Wang","doi":"10.3760/CMA.J.CN371468-20190924-00618","DOIUrl":"https://doi.org/10.3760/CMA.J.CN371468-20190924-00618","url":null,"abstract":"Objective \u0000To explore the effect of cognitive behavior orientation group psychotherapy on coping style, time management and family function of middle school students with internet addiction, and provide theoretical basis for the internet addiction psychotherapy system. \u0000 \u0000 \u0000Methods \u0000Based on IAT, 70 internet addiction middle school students were screened and divided into control group and experimental group according to random number table method.The control group was only given conventionally psychological and drug treatments, the experimental group participated in cognitive behavioral orientation group psychotherapy on the basis of the treatment of the control group.Thirty-two people in the control group and thirty-three people in the experimental group completed the treatment.Before and after treatment, the two groups of middle school students were evaluated by the internet IAT, the SCSQ, the ATMD and the FAD. \u0000 \u0000 \u0000Results \u0000There was no significant difference in the scales between the two groups of internet addiction middle school students before treatment (all P>0.05). After the intervention of the experimental group, the differences in the positive response (1.89±0.51), negative response (1.55±0.51), time monitoring (58.39±12.10), time value (26.64±4.48), time efficacy (30.42±5.18), and roles(18.85±2.40), communication(24.18±3.77), behavior control (18.82±2.57) and general functioning(24.79±3.90) of FAD were statistically significant compared with the control group (1.62±0.44), (1.84±0.55), (52.09±11.72), (19.34±3.96), (21.91±6.13), (21.16±2.63), (26.09±3.75), (20.59±2.54), (28.69±3.68) and the pre-intervention period (1.46±0.48), (1.97±0.56), (48.73±13.46), (18.27±4.84), (20.00±5.79), (21.76±2.72), (26.58±3.86), (19.76±2.96), (29.27±4.76) (all P<0.05). There were significant differences in problem-solving (12.67±2.50) and affective responsiveness (14.03±3.73) scores of the FAD between the experimental group and the pre-intervention group (14.15±2.83), (14.61±3.66) (all P<0.05). There were significant differences in SCSQ and ATMD before and after treatment in the control group (all P<0.05). \u0000 \u0000 \u0000Conclusion \u0000Cognitive behavior orientation group psychotherapy can optimize the coping style, ameliorate their time management ability and significantly improve the role, communication, behavior control and overall function of family function of middle school students with internet addiction. \u0000 \u0000 \u0000Key words: \u0000Cognitive behavior therapy; Group psychotherapy; Middle school student; Internet addiction; Coping style; Time management; Family function","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"29 1","pages":"136-141"},"PeriodicalIF":0.0,"publicationDate":"2020-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47231592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-20DOI: 10.3760/CMA.J.CN371468-20190104-00008
H. Feng, Feng Li, Qing Wang
Objective To explore the effect of family function on behavior problems and family function of 4-6-year-old children. Methods The children behavior checklist (CBCL) and family assessment device (FAD) were used to investigate 416 fathers or mothers of 4-6-year-old children.The nonparametric test, Spearman correlation and binary logistic regression analysis were performed by SPSS 20.0. Results The scores of family function were 1.92(1.67, 2.17). Spearman correlation analysis showed that children's behavioral problems were positively correlated with communication (r=0.102), role (r=0.215), emotional response (r=0.158), emotional intervention (r=0.177) and behavior control(r=0.140), (all P<0.05). Logistic regression analysis showed that emotional intervention could predict children's behavior problems (B=1.024, OR=2.786, 95%CI=1.354-5.733). Conclusion Emotional intervention in family function is the influencing factor of behavior level of 4-6 years old children. Key words: Preschool children; Behavioral problems; Family function; Emotional intervention function
{"title":"The influence of family function on behavior problems of children aged 4 to 6","authors":"H. Feng, Feng Li, Qing Wang","doi":"10.3760/CMA.J.CN371468-20190104-00008","DOIUrl":"https://doi.org/10.3760/CMA.J.CN371468-20190104-00008","url":null,"abstract":"Objective \u0000To explore the effect of family function on behavior problems and family function of 4-6-year-old children. \u0000 \u0000 \u0000Methods \u0000The children behavior checklist (CBCL) and family assessment device (FAD) were used to investigate 416 fathers or mothers of 4-6-year-old children.The nonparametric test, Spearman correlation and binary logistic regression analysis were performed by SPSS 20.0. \u0000 \u0000 \u0000Results \u0000The scores of family function were 1.92(1.67, 2.17). Spearman correlation analysis showed that children's behavioral problems were positively correlated with communication (r=0.102), role (r=0.215), emotional response (r=0.158), emotional intervention (r=0.177) and behavior control(r=0.140), (all P<0.05). Logistic regression analysis showed that emotional intervention could predict children's behavior problems (B=1.024, OR=2.786, 95%CI=1.354-5.733). \u0000 \u0000 \u0000Conclusion \u0000Emotional intervention in family function is the influencing factor of behavior level of 4-6 years old children. \u0000 \u0000 \u0000Key words: \u0000Preschool children; Behavioral problems; Family function; Emotional intervention function","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"29 1","pages":"168-171"},"PeriodicalIF":0.0,"publicationDate":"2020-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43279868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-20DOI: 10.3760/CMA.J.CN371468-20190812-00543
Hongxia Ma, Ying-kai Li, Yu Liang, Yan Liu
Objective To explore the effect of negative affect on internet addiction among college students, and the mediating effect of fatigue. Methods Totally 8 371 freshmen from North China University of Science and Technology were assessed with Chen Shuhui Chinese Network Scale, Fatigue Assessment Scale and Positive Negative Emotion Scale.SPSS 23.0 was used to analyze the data and test the intermediary effect. Results Both of the total score of internet addiction scale and the scores of each factor were negatively correlated with positive emotions scores (r=-0.337- -0.269, P<0.01). However, theose were positively correlated with the negative emotion scores(r=0.338-0.417, P<0.01), the fatigue severity scores(r=0.029-0.040, P<0.01), and the environment specific score and the result score of fatigue(r=0.021-0.028, P<0.05). The emotion and fatigue of college students could predict internet addiction, which could explain 36.9% variation of total score of internet addiction(F=979.336, P<0.01). Fatigue played a part in mediating between internet addiction and negative emotions. Conclusion Negative emotions not only directly affect the degree of internet addiction of college students, but also indirectly affect the degree of internet addiction of college students through part of the intermediary role of fatigue. Key words: Internet addiction; Positive affect; Negative affect; Fatigue
{"title":"The effect of negative affect on internet addiction and the mediating effect of fatigue among college students","authors":"Hongxia Ma, Ying-kai Li, Yu Liang, Yan Liu","doi":"10.3760/CMA.J.CN371468-20190812-00543","DOIUrl":"https://doi.org/10.3760/CMA.J.CN371468-20190812-00543","url":null,"abstract":"Objective \u0000To explore the effect of negative affect on internet addiction among college students, and the mediating effect of fatigue. \u0000 \u0000 \u0000Methods \u0000Totally 8 371 freshmen from North China University of Science and Technology were assessed with Chen Shuhui Chinese Network Scale, Fatigue Assessment Scale and Positive Negative Emotion Scale.SPSS 23.0 was used to analyze the data and test the intermediary effect. \u0000 \u0000 \u0000Results \u0000Both of the total score of internet addiction scale and the scores of each factor were negatively correlated with positive emotions scores (r=-0.337- -0.269, P<0.01). However, theose were positively correlated with the negative emotion scores(r=0.338-0.417, P<0.01), the fatigue severity scores(r=0.029-0.040, P<0.01), and the environment specific score and the result score of fatigue(r=0.021-0.028, P<0.05). The emotion and fatigue of college students could predict internet addiction, which could explain 36.9% variation of total score of internet addiction(F=979.336, P<0.01). Fatigue played a part in mediating between internet addiction and negative emotions. \u0000 \u0000 \u0000Conclusion \u0000Negative emotions not only directly affect the degree of internet addiction of college students, but also indirectly affect the degree of internet addiction of college students through part of the intermediary role of fatigue. \u0000 \u0000 \u0000Key words: \u0000Internet addiction; Positive affect; Negative affect; Fatigue","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"29 1","pages":"163-167"},"PeriodicalIF":0.0,"publicationDate":"2020-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42469831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-20DOI: 10.3760/CMA.J.CN371468-20190914-00639
G. Liu, Jiexuan Li, Limei Xiao, Xiao-hong Zhu, Y. Cai
Objective To explore the mediating role of family cohesion between family expressiveness and preschool children's behavior. Methods Using the method of stratified cluster random sampling, the parents of 1 213 children in Shenzhen kindergartens were assessed by the Achenbach child behavior checklist (parent questionnaire) (CBCL, 4-16 years) and family environment scale-Chinese version (FES-CV). After the survey, SPSS 24.0 was used to conduct the data analysis and the Bootstrap method was used to test the mediation effect. Results (1)The total score of children's behavior 147.0(135.0, 163.0) was found to be significantly negatively correlated with family expressiveness score 6.0 (5.0, 7.0) and family cohesion score 8.0 (6.0, 9.0), and the correlation coefficients were -0.145 and -0.187(both P<0.01). (2) Family expressiveness score was positively related to family cohesion score (r=0.443, P<0.01). (3)The direct effect of family expressiveness on children's behavior was -0.072, and the 95% confidence interval was (-0.133, -0.010). Family cohesion had a mediating effect between family expressiveness and children's behavior, 95% confidence interval was (-0.129, -0.058), and the mediating effect accounted for 56.4% of the total effect. Conclusion Family cohesion plays a partial mediating role between family expressiveness and children's behavior. Key words: Preschool children’s behavior; Family expressiveness; Family cohesion; Mediating role
{"title":"The mediating role of family cohesion between family expressiveness and preschool children's behavior","authors":"G. Liu, Jiexuan Li, Limei Xiao, Xiao-hong Zhu, Y. Cai","doi":"10.3760/CMA.J.CN371468-20190914-00639","DOIUrl":"https://doi.org/10.3760/CMA.J.CN371468-20190914-00639","url":null,"abstract":"Objective \u0000To explore the mediating role of family cohesion between family expressiveness and preschool children's behavior. \u0000 \u0000 \u0000Methods \u0000Using the method of stratified cluster random sampling, the parents of 1 213 children in Shenzhen kindergartens were assessed by the Achenbach child behavior checklist (parent questionnaire) (CBCL, 4-16 years) and family environment scale-Chinese version (FES-CV). After the survey, SPSS 24.0 was used to conduct the data analysis and the Bootstrap method was used to test the mediation effect. \u0000 \u0000 \u0000Results \u0000(1)The total score of children's behavior 147.0(135.0, 163.0) was found to be significantly negatively correlated with family expressiveness score 6.0 (5.0, 7.0) and family cohesion score 8.0 (6.0, 9.0), and the correlation coefficients were -0.145 and -0.187(both P<0.01). (2) Family expressiveness score was positively related to family cohesion score (r=0.443, P<0.01). (3)The direct effect of family expressiveness on children's behavior was -0.072, and the 95% confidence interval was (-0.133, -0.010). Family cohesion had a mediating effect between family expressiveness and children's behavior, 95% confidence interval was (-0.129, -0.058), and the mediating effect accounted for 56.4% of the total effect. \u0000 \u0000 \u0000Conclusion \u0000Family cohesion plays a partial mediating role between family expressiveness and children's behavior. \u0000 \u0000 \u0000Key words: \u0000Preschool children’s behavior; Family expressiveness; Family cohesion; Mediating role","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"29 1","pages":"159-162"},"PeriodicalIF":0.0,"publicationDate":"2020-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45317125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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