Pub Date : 2024-06-14DOI: 10.1109/JSEN.2024.3391189
Fernando Cesar Rufino;Cassio Roberto de Almeida;Geovana Sales;Rodrigo César;Melissa Vidal;Jeany Delafiori;Arthur de Oliveira;Estela Busanello;Rinaldo Siciliano;José Carlos Nicolau;Adriadne Bertolin;Rócio Salsoso;Fabiana Marcondes-Braga;Thebano Santos;Duniskys Larrude;Angelo Gobbi;Carlos Costa;Ricardo Cotrin Teixeira;Rodrigo Catharino;José Alexandre Diniz
In this work, we report a graphene field-effect transistor (GFET) biosensor platform able to sense the SARS-CoV-2 contamination in blood plasma and saliva. The GFET was fabricated on a Si/SiO2 wafer with thin metallic films deposited by sputtering. The gate structure is formed by Ti/Au and the source/drain structure are formed by TiN layer. The dielectric gate is formed by 10 nm TiO2. The transistor channel is formed by ten parallel ribbons of monolayer graphene defined by photolithography and O2 plasma etching. The virus sensing tests were performed with contaminated and non-contaminate SARS-CoV-2 plasma and saliva as analytes on the channel region. The channel shape allows the analyte to contact the ten graphene ribbons and the TiO2 gate dielectric. The sensitivity of the GFET biosensor to SARS-CoV-2 was evidenced by drain-source current versus gate-source voltage ( ${I}_{text {DS}} times {V}_{text {GS}}$