Pub Date : 2021-04-28DOI: 10.37895/2071-8004-2020-24-4-43-53
N. Gorbatova, D. Safin, E. Gasanova, A. Sirotkin, G. Kuzmin, A. Tertychny, O. Tikhonevich, M. Remennicova, S. Zolotov
Rationale. The existing techniques for treating skin capillary angiodysplasias, including «laser» photodestruction, are not effective enough and often cause undesirable thermal damage and cicatricial deformities of the skin. Thus, the effective removal of this vascular pathology is still relevant and requires further solution.Purpose. To study the nature of thermal injuries and wound regenerative processes after «green» laser irradiation with wavelength 525 nm so as to find out if it may be used for selective photodestruction of subepithelial pathological vascular structures, including angiodysplasias of skin capillaries.Material and Methods. Scallops of alive white chickens were taken as a biological model of vascular structures for in vivo studies. An experimental solid-state laser generating «green» light with wavelength 525 nm was used. This laser light has similar peaks of the absorption coefficient of hemoglobin and oxyhemoglobin which are found in skin capillaries. Features of damage and dynamics of regenerative process in the irradiated area were studied at the model of vascular structures using findings of morphological macroscopic and histological examinations.Results. Findings of the present experimental trial have inspired that selective photodestruction of subepithelial vascular structures of scallops is possible with minimal damage to the epithelium, including growth zones. In irradiated areas, one could see whitening and smoothing of the surface due to closure of vessel lumens in the subepithelial zone and formation of collagenosis layer there, as well as epithelialization of wound surface in physiological terms without any formation of cicatricial deformation of the skin.Conclusion. The selective effect of 525 nm «green» laser light at subepithelial vascular structures with minimal skin damage has been confirmed. It opens a way to apply this light for selective photodestruction of capillary angiodysplasias of the skin with good clinical and esthetic outcomes.
{"title":"Experimental substantiation of «green» laser light application for selective photodestruction of capillary angiodysplasia of the skin","authors":"N. Gorbatova, D. Safin, E. Gasanova, A. Sirotkin, G. Kuzmin, A. Tertychny, O. Tikhonevich, M. Remennicova, S. Zolotov","doi":"10.37895/2071-8004-2020-24-4-43-53","DOIUrl":"https://doi.org/10.37895/2071-8004-2020-24-4-43-53","url":null,"abstract":"Rationale. The existing techniques for treating skin capillary angiodysplasias, including «laser» photodestruction, are not effective enough and often cause undesirable thermal damage and cicatricial deformities of the skin. Thus, the effective removal of this vascular pathology is still relevant and requires further solution.Purpose. To study the nature of thermal injuries and wound regenerative processes after «green» laser irradiation with wavelength 525 nm so as to find out if it may be used for selective photodestruction of subepithelial pathological vascular structures, including angiodysplasias of skin capillaries.Material and Methods. Scallops of alive white chickens were taken as a biological model of vascular structures for in vivo studies. An experimental solid-state laser generating «green» light with wavelength 525 nm was used. This laser light has similar peaks of the absorption coefficient of hemoglobin and oxyhemoglobin which are found in skin capillaries. Features of damage and dynamics of regenerative process in the irradiated area were studied at the model of vascular structures using findings of morphological macroscopic and histological examinations.Results. Findings of the present experimental trial have inspired that selective photodestruction of subepithelial vascular structures of scallops is possible with minimal damage to the epithelium, including growth zones. In irradiated areas, one could see whitening and smoothing of the surface due to closure of vessel lumens in the subepithelial zone and formation of collagenosis layer there, as well as epithelialization of wound surface in physiological terms without any formation of cicatricial deformation of the skin.Conclusion. The selective effect of 525 nm «green» laser light at subepithelial vascular structures with minimal skin damage has been confirmed. It opens a way to apply this light for selective photodestruction of capillary angiodysplasias of the skin with good clinical and esthetic outcomes.","PeriodicalId":10008,"journal":{"name":"Chinese Journal of Laser Medicine & Surgery","volume":"3 1","pages":"43-53"},"PeriodicalIF":0.0,"publicationDate":"2021-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89531972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-29DOI: 10.37895/2071-8004-2020-24-2-3-9-14
A. Baranov, A. Kornev, A. A. Boriskin, R. D. Mustafayev, V. Derbenev, D. Gorin, K. T. Efendiyev
Purpose . To study the accumulation of photosensitizer Photoditazine in the bladder mucous in chronic cystitis. Material and methods . 22 patients with chronic cystitis were taken into the study. The time of Photoditazine accumulation in the bladder mucous was determined with a multi-channel optical fiber spectroanalyzer («LESA-01-BIOSPEC»). Photodynamic therapy (PDT) was done with laser «ATKUS-2» having adjustable output power up to 2 W and wavelength 661 ± 0.03 nm. Results . The performed fluorescence spectroscopy has revealed that the maximal accumulation time of Photoditazine in the bladder mucous in chronic cystitis is 120–150 minutes. After laser exposure, by spectroscopy finings, fluorescence intensity decreases by 72.3% which indicates a pronounced photosensitizer excitation and an active photodynamic reaction. Conclusion . The optimal time for laser photodynamic therapy in chronic cystitis is 2–2.5 hours after photosensitizer injection. Spectroscopy findings after laser exposure demonstrate the effectiveness of photodynamic therapy in chronic cystitis.
{"title":"Photosensitizer accumulation in the bladder mucosa in chronic cystitis","authors":"A. Baranov, A. Kornev, A. A. Boriskin, R. D. Mustafayev, V. Derbenev, D. Gorin, K. T. Efendiyev","doi":"10.37895/2071-8004-2020-24-2-3-9-14","DOIUrl":"https://doi.org/10.37895/2071-8004-2020-24-2-3-9-14","url":null,"abstract":"Purpose . To study the accumulation of photosensitizer Photoditazine in the bladder mucous in chronic cystitis. Material and methods . 22 patients with chronic cystitis were taken into the study. The time of Photoditazine accumulation in the bladder mucous was determined with a multi-channel optical fiber spectroanalyzer («LESA-01-BIOSPEC»). Photodynamic therapy (PDT) was done with laser «ATKUS-2» having adjustable output power up to 2 W and wavelength 661 ± 0.03 nm. Results . The performed fluorescence spectroscopy has revealed that the maximal accumulation time of Photoditazine in the bladder mucous in chronic cystitis is 120–150 minutes. After laser exposure, by spectroscopy finings, fluorescence intensity decreases by 72.3% which indicates a pronounced photosensitizer excitation and an active photodynamic reaction. Conclusion . The optimal time for laser photodynamic therapy in chronic cystitis is 2–2.5 hours after photosensitizer injection. Spectroscopy findings after laser exposure demonstrate the effectiveness of photodynamic therapy in chronic cystitis.","PeriodicalId":10008,"journal":{"name":"Chinese Journal of Laser Medicine & Surgery","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85987057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-29DOI: 10.37895/2071-8004-2020-24-2-3-45-53
J. Kosayev, I. Hasanov, N. S. Abushov, G. T. Taghi-zada
Purpose . To study potentials for correcting hemostasis and hemorheology with intravenous laser blood irradiation (ILBI) and cytokine therapy (CT) in indirect revascularization at the perioperative period in patients with critical ischemia of lower extremities. Material and methods . A prospective controlled clinical trial included 162 patients with critical lower limb ischemia (CLLI) having distal arterial steno-occlusion who had indirect revascularization surgery. CLLI etiological factors were: obliterating atherosclerosis in 108 (66.7%) patients and obliterating thromboangiitis in 54 (33.3%) patients. 56 patients had chronic ischemia of degree III; 106 patients – chronic ischemia of degree IV. All patients were divided into 5 groups who had various curative modalities at their perioperative period: Group I (n = 34) –standard treatment; Group II (n = 32) – standard treatment + ILBI; Group III (n = 32) – standard treatment + CT with Roncoleukin; Group IV (n = 33) – standard treatment + ILBI + CT; patients from Group V (n = 31) in revascularizing osteotrepanation had intraosseous marrow laser irradiation (IOLI) – standard treatment + ILBI + CT. The researchers also studied dynamics of hemostatic parameters (fibrinogen – F, fibrinolytic activity – FA, fibrin degradation products – PDF, activity of antithrombin-III, plasminogen – P) and hemorheology (erythrocyte deformability – DE, von Willebrand factor – WF, ADP induced platelet aggregation). The obtained hemostasis and hemorheology findings were compared with identical parameters of 48 practically healthy subjects («reference group»). Results . On admission, patients with CLLI in distal steno-occlusion had a sharp change in their hemostasis formula shifting towards hypercoagulation and deterioration of hemorheology. ILBI and CT techniques applied either separately or in combination with other therapeutic measures in the perioperative period of indirect revascularization normalized parameters of blood coagulation system (for all parameters – p < 0.05; r = 0.4) and of hemorheology (for DE – p < 0.05; r = 0.4; for WF and ADP-induced platelet aggregation – p < 0.05; r = 0.3). The best results were obtained under the combination of ILBI and CT at the perioperative period of indirect revascularization, especially in revascularizing osteotrepanation with IOLI. Conclusion . ILBI and CT applied in combination with standard treatment at the perioperative period in indirect revascularization reliably correct hemostasis and hemorheology in patients with CLLI and distal arterial steno-occlusion.
{"title":"Correction of hemostasis and hemorheology with intravenous laser blood irradiation and cytokinotherapy in indirect revascularization at the perioperative period in patients with critical ischemia of their lower extremities","authors":"J. Kosayev, I. Hasanov, N. S. Abushov, G. T. Taghi-zada","doi":"10.37895/2071-8004-2020-24-2-3-45-53","DOIUrl":"https://doi.org/10.37895/2071-8004-2020-24-2-3-45-53","url":null,"abstract":"Purpose . To study potentials for correcting hemostasis and hemorheology with intravenous laser blood irradiation (ILBI) and cytokine therapy (CT) in indirect revascularization at the perioperative period in patients with critical ischemia of lower extremities. Material and methods . A prospective controlled clinical trial included 162 patients with critical lower limb ischemia (CLLI) having distal arterial steno-occlusion who had indirect revascularization surgery. CLLI etiological factors were: obliterating atherosclerosis in 108 (66.7%) patients and obliterating thromboangiitis in 54 (33.3%) patients. 56 patients had chronic ischemia of degree III; 106 patients – chronic ischemia of degree IV. All patients were divided into 5 groups who had various curative modalities at their perioperative period: Group I (n = 34) –standard treatment; Group II (n = 32) – standard treatment + ILBI; Group III (n = 32) – standard treatment + CT with Roncoleukin; Group IV (n = 33) – standard treatment + ILBI + CT; patients from Group V (n = 31) in revascularizing osteotrepanation had intraosseous marrow laser irradiation (IOLI) – standard treatment + ILBI + CT. The researchers also studied dynamics of hemostatic parameters (fibrinogen – F, fibrinolytic activity – FA, fibrin degradation products – PDF, activity of antithrombin-III, plasminogen – P) and hemorheology (erythrocyte deformability – DE, von Willebrand factor – WF, ADP induced platelet aggregation). The obtained hemostasis and hemorheology findings were compared with identical parameters of 48 practically healthy subjects («reference group»). Results . On admission, patients with CLLI in distal steno-occlusion had a sharp change in their hemostasis formula shifting towards hypercoagulation and deterioration of hemorheology. ILBI and CT techniques applied either separately or in combination with other therapeutic measures in the perioperative period of indirect revascularization normalized parameters of blood coagulation system (for all parameters – p < 0.05; r = 0.4) and of hemorheology (for DE – p < 0.05; r = 0.4; for WF and ADP-induced platelet aggregation – p < 0.05; r = 0.3). The best results were obtained under the combination of ILBI and CT at the perioperative period of indirect revascularization, especially in revascularizing osteotrepanation with IOLI. Conclusion . ILBI and CT applied in combination with standard treatment at the perioperative period in indirect revascularization reliably correct hemostasis and hemorheology in patients with CLLI and distal arterial steno-occlusion.","PeriodicalId":10008,"journal":{"name":"Chinese Journal of Laser Medicine & Surgery","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88980069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-29DOI: 10.37895/2071-8004-2020-24-2-3-62-69
V. S. Shiryaev, F. M. Shvedsky, M. Grebenkina, V. Karandashov, M. B. Potievsky, D. S. Gorin, O. I. Bugrovskaya, A. Khosrovyan
Purpose . To develop a technique for potentiating the low-opioid multimodal anesthesia with LED radiation in the red range of the spectrum at 650 ± 20 nm using autonomous optoelectronic devices. Material and methods . Portable semiconductor LED devices AFC 660 k-630/670 emitting in the red range with wavelength 650 ± 20 nm were used for contact LED exposure. 78 abdominal patients (59 women and 19 men), aged 65–87, with concomitant diseases had the multimodal anesthesia. Patients' weight ranged from 68 to 127 kg. All patients had the 3rd degree of anesthetic risk by MNOAR classification. Patients were divided into two groups: studied and control. In the studied group (n = 52), 35 patients had planned laparoscopic cholecystectomy; 17 patients had laparoscopic hernia repair. In the control group (n = 26), 19 patients had laparoscopic cholecystectomy, and 7 patients had laparoscopic hernia repair with alloplasty. A comparative study of two protective techniques against surgical aggression was made: studied group – multimodal anesthesia potentiated by contact LED exposure at the projection of large vessels with AFC bracelet (physiotherapeutic LED apparatus); control group (n = 26) – multimodal anesthesia not potentiated with contact LED exposure. Results . It has been found out that the potentiated multimodal anesthesia with portable semiconductor LED device AFC 660 k-630/670 in the red range with wavelength of 650 ± 20 nm reduced fentanyl consumption in the studied group by 3 times (in the control group fentanyl consumption was 4.76 ± 0, 39 μg/kg/h; in the studied group – 1.53 ± 0.15 μg/kg/h). Peripheral hemodynamic parameters at all stages of surgical intervention practically did not show any significant changes from the initial values. The index of central hemodynamics CI in the studied group increased at the end of the surgery from 2.53 ± 0.36 l/min m 2 to 3.61 ± 0.46 l/min m 2 . The total peripheral vascular resistance in the studied group decreased compared to the initial values from 1654.2 ± 345.1 din.c.cm –5 to 1136.7 ± 485.1 din·c·cm –5 . In the control group, CI increased comparing to the initial values from 2.79 ± 0.36 l/min m 2 to 3.14 ± 0.37 l/min m 2 . Total peripheric vascular resistance in the control group decreased from 1448.5 ± 344.5 din·c·cm –5 to 1223.9 ± 437.1 din·c·cm –5 in comparison with the initial values. Conclusion . Potentiation of multimodal anesthesia by contact LED exposure during abdominal surgery in patients of the studied group stabilized hemodynamics, increased the cardiac index and decreased total peripheral vascular resistance better than in the control group during anesthesiologic support.
{"title":"The little opioid multimodal anesthesiapotentiated by modern led irradiation of blood in red 650 nm range","authors":"V. S. Shiryaev, F. M. Shvedsky, M. Grebenkina, V. Karandashov, M. B. Potievsky, D. S. Gorin, O. I. Bugrovskaya, A. Khosrovyan","doi":"10.37895/2071-8004-2020-24-2-3-62-69","DOIUrl":"https://doi.org/10.37895/2071-8004-2020-24-2-3-62-69","url":null,"abstract":"Purpose . To develop a technique for potentiating the low-opioid multimodal anesthesia with LED radiation in the red range of the spectrum at 650 ± 20 nm using autonomous optoelectronic devices. Material and methods . Portable semiconductor LED devices AFC 660 k-630/670 emitting in the red range with wavelength 650 ± 20 nm were used for contact LED exposure. 78 abdominal patients (59 women and 19 men), aged 65–87, with concomitant diseases had the multimodal anesthesia. Patients' weight ranged from 68 to 127 kg. All patients had the 3rd degree of anesthetic risk by MNOAR classification. Patients were divided into two groups: studied and control. In the studied group (n = 52), 35 patients had planned laparoscopic cholecystectomy; 17 patients had laparoscopic hernia repair. In the control group (n = 26), 19 patients had laparoscopic cholecystectomy, and 7 patients had laparoscopic hernia repair with alloplasty. A comparative study of two protective techniques against surgical aggression was made: studied group – multimodal anesthesia potentiated by contact LED exposure at the projection of large vessels with AFC bracelet (physiotherapeutic LED apparatus); control group (n = 26) – multimodal anesthesia not potentiated with contact LED exposure. Results . It has been found out that the potentiated multimodal anesthesia with portable semiconductor LED device AFC 660 k-630/670 in the red range with wavelength of 650 ± 20 nm reduced fentanyl consumption in the studied group by 3 times (in the control group fentanyl consumption was 4.76 ± 0, 39 μg/kg/h; in the studied group – 1.53 ± 0.15 μg/kg/h). Peripheral hemodynamic parameters at all stages of surgical intervention practically did not show any significant changes from the initial values. The index of central hemodynamics CI in the studied group increased at the end of the surgery from 2.53 ± 0.36 l/min m 2 to 3.61 ± 0.46 l/min m 2 . The total peripheral vascular resistance in the studied group decreased compared to the initial values from 1654.2 ± 345.1 din.c.cm –5 to 1136.7 ± 485.1 din·c·cm –5 . In the control group, CI increased comparing to the initial values from 2.79 ± 0.36 l/min m 2 to 3.14 ± 0.37 l/min m 2 . Total peripheric vascular resistance in the control group decreased from 1448.5 ± 344.5 din·c·cm –5 to 1223.9 ± 437.1 din·c·cm –5 in comparison with the initial values. Conclusion . Potentiation of multimodal anesthesia by contact LED exposure during abdominal surgery in patients of the studied group stabilized hemodynamics, increased the cardiac index and decreased total peripheral vascular resistance better than in the control group during anesthesiologic support.","PeriodicalId":10008,"journal":{"name":"Chinese Journal of Laser Medicine & Surgery","volume":"54 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90883185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-29DOI: 10.37895/2071-8004-2020-24-2-3-22-28
V. M. Legostaev, G. V. Balitsky, O. Y. Babenkov, M. L. Maldonado
A clinical case of stenosing cancer in the only lung lobe treated with endoscopic photodynamic therapy (PDT) in combination with argon-plasma coagulation (APC) is presented. Material and methods. A patient with central cancer of the left lung (pT2N0M0, st 1b) had a radical extended pneumonectomy on the left. In 28 months, central metachronous endobronchial cancer of the right main bronchus (cT1N0M0 stIA) developed. Histological examination revealed G2 squamous cell carcinoma. Because of bronchial stenosis in the only lung lobe, the patient was treated with endoscopic PDT followed by APC at the site of the tumor. Lakhta-Milon laser (Russia) with wavelength 662 nm, optical fibers having a microlens and a cylindrical diffuser 1.0 cm long were used for the treatment. Radiation power 500 mW, energy density 70 J/cm2. Three hours before PDT, the patient was injected intravenously and dropwise 100 mg of Photoditazine dissolved in 100 ml of physiological solution (ratio 1.2 mg per 1 kg of body weight). Irradiation was made from 3 positions: a flexible light guide with a microlens irradiated the upper lobe spur; then the tumor was irradiated with a light guide having a cylindrical diffuser via residual bronchial lumens. APC of the tumor was performed electrosurgically with device APC ERBE VIO 300D. ForcedCoag mode, power 80 W, argon flow rate 1 liter per minute. Results. One day after the first PDT session, dyspnea became gradually less; on day 6 the patient had the second PDT session by the same technique. After it, his condition improved, vital signs stabilized: shortness of breath and expiratory stridor decreased; respiratory rate – 22 per/min; heart rate – 94 beats/min; sat. O2 = 86%. Later, despite multiple courses of chemotherapy, the tumor was growing which required regular PDT-APC recanalization at 2–6-week intervals. Such a combined endoscopic treatment maintained a satisfactory quality of life in the patient for 1.5 years. Conclusion. PDT combined with APC can be used as an independent effective technique in antitumor therapy in patients with stenosing lung cancer when other surgical and chemoradial options are ineffective. It also significantly prolongs the life of patients.
{"title":"Сombined endoscopic photodynamic therapy for stenosing cancer in the only lung lobe","authors":"V. M. Legostaev, G. V. Balitsky, O. Y. Babenkov, M. L. Maldonado","doi":"10.37895/2071-8004-2020-24-2-3-22-28","DOIUrl":"https://doi.org/10.37895/2071-8004-2020-24-2-3-22-28","url":null,"abstract":"A clinical case of stenosing cancer in the only lung lobe treated with endoscopic photodynamic therapy (PDT) in combination with argon-plasma coagulation (APC) is presented. Material and methods. A patient with central cancer of the left lung (pT2N0M0, st 1b) had a radical extended pneumonectomy on the left. In 28 months, central metachronous endobronchial cancer of the right main bronchus (cT1N0M0 stIA) developed. Histological examination revealed G2 squamous cell carcinoma. Because of bronchial stenosis in the only lung lobe, the patient was treated with endoscopic PDT followed by APC at the site of the tumor. Lakhta-Milon laser (Russia) with wavelength 662 nm, optical fibers having a microlens and a cylindrical diffuser 1.0 cm long were used for the treatment. Radiation power 500 mW, energy density 70 J/cm2. Three hours before PDT, the patient was injected intravenously and dropwise 100 mg of Photoditazine dissolved in 100 ml of physiological solution (ratio 1.2 mg per 1 kg of body weight). Irradiation was made from 3 positions: a flexible light guide with a microlens irradiated the upper lobe spur; then the tumor was irradiated with a light guide having a cylindrical diffuser via residual bronchial lumens. APC of the tumor was performed electrosurgically with device APC ERBE VIO 300D. ForcedCoag mode, power 80 W, argon flow rate 1 liter per minute. Results. One day after the first PDT session, dyspnea became gradually less; on day 6 the patient had the second PDT session by the same technique. After it, his condition improved, vital signs stabilized: shortness of breath and expiratory stridor decreased; respiratory rate – 22 per/min; heart rate – 94 beats/min; sat. O2 = 86%. Later, despite multiple courses of chemotherapy, the tumor was growing which required regular PDT-APC recanalization at 2–6-week intervals. Such a combined endoscopic treatment maintained a satisfactory quality of life in the patient for 1.5 years. Conclusion. PDT combined with APC can be used as an independent effective technique in antitumor therapy in patients with stenosing lung cancer when other surgical and chemoradial options are ineffective. It also significantly prolongs the life of patients.","PeriodicalId":10008,"journal":{"name":"Chinese Journal of Laser Medicine & Surgery","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80854060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-29DOI: 10.37895/2071-8004-2020-24-2-3-29-36
I. M. Baybekov, Kh. Sh. Rakhmanov, M. M. Irkhanov
Purpose: to study the effect of low-level laser therapy (LLLT) and preparation Cholisal at the microflora of oral mucous in prosthetic stomatitis (PS). Material and methods . Patients were divided into the following groups: Group 1 – control, without PS signs; Group 2 with PS had conventional treatment (sanitation of the oral cavity, removal of supra- and subgingival dental deposits, elimination of traumatic occlusion nodes, curettage of pathological pockets); Group 3 with PS had conventional treatment plus LLLT; Group 4 with PS had conventional treatment plus Cholisal; Group 5 with PS had conventional treatment plus LILI and Cholisal. The oral mucosa of patients with PS was irradiated externally every day for 7 days during 3 min. Matrix-VLOK laser with KL–VLOK head, wavelength of 0.63 mkm – an analog of helium-neon laser (red light) -, output power 2 mW was used. The irradiation dosage was calculated by the equation: D = ( P / S ) × t , where D is radiation dose, P (W) is radiation power on the wound surface, S (cm 2 ) is area of wound radiation, t (s) is exposure time. Thus, if the erosion surface area is 1–2 cm 2 , the irradiation dose has to be 3–6 J. Cholisal was applied topically before night sleep without subsequent LLLT. In the combined application of LLLT and Cholisal, irradiation was done in the morning . Results. It has been found out that LLLT reduces inflammatory processes and the level of microbial contamination in the oral mucous. Cholisal also reduces microbial contamination. The most effective technique for treating the oral mucous is a combined application of LLLT and Cholisal. Conclusion . The presented studies demonstrate effective outcomes in combined application of LLLT and Cholisal for reducing inflammatory processes and microbial contamination of the oral mucous in prosthetic stomatitis.
目的:探讨低水平激光治疗(LLLT)和胆利沙制剂对修复性口炎(PS)口腔黏膜菌群的影响。材料和方法。将患者分为两组:第一组为对照组，无PS体征;2组采用常规治疗(口腔卫生、清除龈上、龈下牙沉积、清除外伤性咬合淋巴结、刮除病理性牙袋);PS组3采用常规治疗加LLLT治疗;4组PS患者给予常规治疗加胆利沙;5组PS患者在常规治疗的基础上加用LILI和Cholisal。采用KL-VLOK头Matrix-VLOK激光器，波长0.63 mkm，模拟氦氖激光(红光)，输出功率2 mW，每天对PS患者口腔黏膜进行3 min的外照射，持续7天。辐照剂量计算公式为:D = (P / S) × t，其中D为辐射剂量，P (W)为伤口表面辐射功率，S (cm2)为伤口辐射面积，t (S)为照射时间。因此，如果侵蚀表面积为1-2 cm 2，照射剂量必须为3-6 J. Cholisal在夜间睡觉前局部施用，没有后续的LLLT。在LLLT和Cholisal联合应用中，照射在早晨进行。结果。已经发现，LLLT可以减少炎症过程和口腔粘膜微生物污染水平。胆碱还能减少微生物污染。治疗口腔黏膜最有效的方法是联合应用LLLT和Cholisal。结论。本研究表明，在假体口炎中，LLLT和Cholisal联合应用可有效减少口腔黏膜的炎症过程和微生物污染。
{"title":"Antimicrobial and anti-inflammatory effects of laser irradiation and Cholisal in the treatment of prosthetic stomatitis","authors":"I. M. Baybekov, Kh. Sh. Rakhmanov, M. M. Irkhanov","doi":"10.37895/2071-8004-2020-24-2-3-29-36","DOIUrl":"https://doi.org/10.37895/2071-8004-2020-24-2-3-29-36","url":null,"abstract":"Purpose: to study the effect of low-level laser therapy (LLLT) and preparation Cholisal at the microflora of oral mucous in prosthetic stomatitis (PS). Material and methods . Patients were divided into the following groups: Group 1 – control, without PS signs; Group 2 with PS had conventional treatment (sanitation of the oral cavity, removal of supra- and subgingival dental deposits, elimination of traumatic occlusion nodes, curettage of pathological pockets); Group 3 with PS had conventional treatment plus LLLT; Group 4 with PS had conventional treatment plus Cholisal; Group 5 with PS had conventional treatment plus LILI and Cholisal. The oral mucosa of patients with PS was irradiated externally every day for 7 days during 3 min. Matrix-VLOK laser with KL–VLOK head, wavelength of 0.63 mkm – an analog of helium-neon laser (red light) -, output power 2 mW was used. The irradiation dosage was calculated by the equation: D = ( P / S ) × t , where D is radiation dose, P (W) is radiation power on the wound surface, S (cm 2 ) is area of wound radiation, t (s) is exposure time. Thus, if the erosion surface area is 1–2 cm 2 , the irradiation dose has to be 3–6 J. Cholisal was applied topically before night sleep without subsequent LLLT. In the combined application of LLLT and Cholisal, irradiation was done in the morning . Results. It has been found out that LLLT reduces inflammatory processes and the level of microbial contamination in the oral mucous. Cholisal also reduces microbial contamination. The most effective technique for treating the oral mucous is a combined application of LLLT and Cholisal. Conclusion . The presented studies demonstrate effective outcomes in combined application of LLLT and Cholisal for reducing inflammatory processes and microbial contamination of the oral mucous in prosthetic stomatitis.","PeriodicalId":10008,"journal":{"name":"Chinese Journal of Laser Medicine & Surgery","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77587198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-29DOI: 10.37895/2071-8004-2020-24-2-3-15-21
E. V. Yaroslavtseva-Isaeva, M. Kaplan, V. Kapinus, I. S. Spichenkova
Objective : to study the effectiveness of photodynamic therapy (PDT) for non-melanoma malignant skin neoplasms with photosensitizer (PS) Photolon in young patients. Material and methods . 59 patients, aged 19–44, with verified diagnosis were treated with PDT technique: basal cell skin cancer (BCSC) – 51 patient; squamous cell skin cancer (SCSC) – 8 patients. Photolon dose was 0.8–1.3 mg/kg. The applied light dose was from 100 to 400 J/cm 2 depending on the clinical and histological form of tumor focus and the contrast index of PS – tumor / healthy skin calculated by findings of fluorescent diagnostics. Results . 6 months after PDT, 84.7% patients with non-melanoma skin cancer cT1-4N0M0 had a complete regression; 11.9% – partial; 3.4% – stabilization. There was a good cosmetic effect as well. It has been revealed that PDT effectiveness in BCSC is higher than that in squamous cell skin cancer; complete regressions was seen in 92.2 and 37.5%, respectively. Relapses during the follow-up period (from 6 months to 10 years) were registered in 8.7% of cases. Conclusion. PDT with Photolon is an effective technique for treating non-melanoma skin cancer with low risk of developing anatomical and functional disorders. It may be a method of choice for treating young people with malignant skin neoplasms.
{"title":"Photodynamic therapy for treating malignant skin tumors in young people","authors":"E. V. Yaroslavtseva-Isaeva, M. Kaplan, V. Kapinus, I. S. Spichenkova","doi":"10.37895/2071-8004-2020-24-2-3-15-21","DOIUrl":"https://doi.org/10.37895/2071-8004-2020-24-2-3-15-21","url":null,"abstract":"Objective : to study the effectiveness of photodynamic therapy (PDT) for non-melanoma malignant skin neoplasms with photosensitizer (PS) Photolon in young patients. Material and methods . 59 patients, aged 19–44, with verified diagnosis were treated with PDT technique: basal cell skin cancer (BCSC) – 51 patient; squamous cell skin cancer (SCSC) – 8 patients. Photolon dose was 0.8–1.3 mg/kg. The applied light dose was from 100 to 400 J/cm 2 depending on the clinical and histological form of tumor focus and the contrast index of PS – tumor / healthy skin calculated by findings of fluorescent diagnostics. Results . 6 months after PDT, 84.7% patients with non-melanoma skin cancer cT1-4N0M0 had a complete regression; 11.9% – partial; 3.4% – stabilization. There was a good cosmetic effect as well. It has been revealed that PDT effectiveness in BCSC is higher than that in squamous cell skin cancer; complete regressions was seen in 92.2 and 37.5%, respectively. Relapses during the follow-up period (from 6 months to 10 years) were registered in 8.7% of cases. Conclusion. PDT with Photolon is an effective technique for treating non-melanoma skin cancer with low risk of developing anatomical and functional disorders. It may be a method of choice for treating young people with malignant skin neoplasms.","PeriodicalId":10008,"journal":{"name":"Chinese Journal of Laser Medicine & Surgery","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73040881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-29DOI: 10.37895/2071-8004-2020-24-2-3-95-103
N. Gorbatova, D. Safin, E. Gasanova, S. Zolotov, A. Sirotkin, G. Kuzmin, A. Tertychny, N. Stankova, M. Remennicova, O. Tikhonevich
Currently, medical specialists still face problems while treating pathological subepithelial capillary structures, in particular, capillary angiodysplasias of the skin. One of the promising techniques for their removal is photothermolysis by laser light of yellow-green spectral range which is selectively absorbed by pigments, hemoglobin, blood in the vessels with further vessel hardening and regression. Purpose . To make a comparative trial in vitro at experimental models so as to confirm the effect of selectivity of «green» laser light at hemoglobin-containing tissues, in particular, at subepithelial vascular structures. Material and methods : An experimental solid-state semiconductor laser, generating green light with wavelength 525 nm which is near the absorption peak of hemoglobin and oxyhemoglobin, was used. Experimental models were cooled samples of the liver, skin and a preparation combined of them as well as laboratory minipigs of Svetlogorsk population. In the trial, the researchers compared changes developed after the irradiation of abovementioned objects with «green» laser light. To make comparison, morphological, macroscopic and histological findings from irradiated zones were analyzed. Results . Specific differences in the damaged zones of experimental models as well as in the liver and skin were found. While examining the liver, one can see locally more pronounced changes and a minus destruction looking like a narrow sphenoid-shaped crater with relatively narrow zones of compact and cellular necrosis, clear boundaries between them as well as unchanged adjacent tissues. On the skin, one can see a minus destruction of much smaller size with zone of peripheral coagulation 3–5 times wider and without compact and cellular layers; there are also no clear boundaries with unchanged tissues. In the combined sample, green laser light – which is less absorbed by the skin- penetrates through it, thus affecting the underlying liver where one can see more pronounced thermal changes, if to compare with the skin. Conclusion . The selectivity effect of «green» laser light with wavelength 525 nm at hemoglobin-containing tissues has been confirmed. This conclusion is a promising finding for applying the selective photothermolysis in pathological subepithelial capillary structures which will ensure precise treatment with minimal damage to skin tissues.
{"title":"Experimental substantiation of the selectivity effect of «green» laser light at hemoglobin-containing tissues","authors":"N. Gorbatova, D. Safin, E. Gasanova, S. Zolotov, A. Sirotkin, G. Kuzmin, A. Tertychny, N. Stankova, M. Remennicova, O. Tikhonevich","doi":"10.37895/2071-8004-2020-24-2-3-95-103","DOIUrl":"https://doi.org/10.37895/2071-8004-2020-24-2-3-95-103","url":null,"abstract":"Currently, medical specialists still face problems while treating pathological subepithelial capillary structures, in particular, capillary angiodysplasias of the skin. One of the promising techniques for their removal is photothermolysis by laser light of yellow-green spectral range which is selectively absorbed by pigments, hemoglobin, blood in the vessels with further vessel hardening and regression. Purpose . To make a comparative trial in vitro at experimental models so as to confirm the effect of selectivity of «green» laser light at hemoglobin-containing tissues, in particular, at subepithelial vascular structures. Material and methods : An experimental solid-state semiconductor laser, generating green light with wavelength 525 nm which is near the absorption peak of hemoglobin and oxyhemoglobin, was used. Experimental models were cooled samples of the liver, skin and a preparation combined of them as well as laboratory minipigs of Svetlogorsk population. In the trial, the researchers compared changes developed after the irradiation of abovementioned objects with «green» laser light. To make comparison, morphological, macroscopic and histological findings from irradiated zones were analyzed. Results . Specific differences in the damaged zones of experimental models as well as in the liver and skin were found. While examining the liver, one can see locally more pronounced changes and a minus destruction looking like a narrow sphenoid-shaped crater with relatively narrow zones of compact and cellular necrosis, clear boundaries between them as well as unchanged adjacent tissues. On the skin, one can see a minus destruction of much smaller size with zone of peripheral coagulation 3–5 times wider and without compact and cellular layers; there are also no clear boundaries with unchanged tissues. In the combined sample, green laser light – which is less absorbed by the skin- penetrates through it, thus affecting the underlying liver where one can see more pronounced thermal changes, if to compare with the skin. Conclusion . The selectivity effect of «green» laser light with wavelength 525 nm at hemoglobin-containing tissues has been confirmed. This conclusion is a promising finding for applying the selective photothermolysis in pathological subepithelial capillary structures which will ensure precise treatment with minimal damage to skin tissues.","PeriodicalId":10008,"journal":{"name":"Chinese Journal of Laser Medicine & Surgery","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78272464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-29DOI: 10.37895/2071-8004-2020-24-2-3-37-44
A. Vlasov, Sh. S. Al-Kubaisi, N. S. Sheiranov, A. Kolesov, M. A. Spirina, F. Ali Fuad, A. Leontiev
Purpose. To study the effectiveness of low-level laser therapy (LLLT) for the correction of homeostatic disorders in severe mechanical jaundice of non-tumor origin at the early postoperative period. Material and methods. The authors present their results of treating 45 patients with mechanical jaundice (MJ) of non-neoplastic genesis and of various severity. Patients were randomized into three groups: Group 1 (n = 15) – patients with mild MJ who were prescribed standard treatment at the postoperative period; Group 2 (n = 15) – patients with severe MJ who were also prescribed standard treatment; Group 3 (n = 15) – patients' state similar to that of Group 2 but who were added laser therapy sessions to their standard treatment. Laser «Matrix» was used for this. The intensity of lipoperoxidation processes, phospholipase activity, microcirculation, hemostasis and liver functional state were assessed. Results. It was found that at the early postoperative period (up to day 8), patients with mechanical jaundice of non-tumor genesis have marked deviations in homeostasis, like oxidative stress, activation of phospholipase system, microcirculatory disorders, hepatic dysfunction and hemostatic disorders, the severity of which is associated with the severity of pathology. The therapeutic effectiveness of basic treatment at early stages in patients with mild MJ was enough, while in patients with severe MJ not always. Conclusion. Supravascular quantum irradiation added to standard therapy in patients with severe mechanical jaundice promotes more rapid restoration of hepatic dysfunction and more effective correction of the homeostatic system.
{"title":"Quantum correction of homeostatic disorders in patients with mechanical jaundice","authors":"A. Vlasov, Sh. S. Al-Kubaisi, N. S. Sheiranov, A. Kolesov, M. A. Spirina, F. Ali Fuad, A. Leontiev","doi":"10.37895/2071-8004-2020-24-2-3-37-44","DOIUrl":"https://doi.org/10.37895/2071-8004-2020-24-2-3-37-44","url":null,"abstract":"Purpose. To study the effectiveness of low-level laser therapy (LLLT) for the correction of homeostatic disorders in severe mechanical jaundice of non-tumor origin at the early postoperative period. Material and methods. The authors present their results of treating 45 patients with mechanical jaundice (MJ) of non-neoplastic genesis and of various severity. Patients were randomized into three groups: Group 1 (n = 15) – patients with mild MJ who were prescribed standard treatment at the postoperative period; Group 2 (n = 15) – patients with severe MJ who were also prescribed standard treatment; Group 3 (n = 15) – patients' state similar to that of Group 2 but who were added laser therapy sessions to their standard treatment. Laser «Matrix» was used for this. The intensity of lipoperoxidation processes, phospholipase activity, microcirculation, hemostasis and liver functional state were assessed. Results. It was found that at the early postoperative period (up to day 8), patients with mechanical jaundice of non-tumor genesis have marked deviations in homeostasis, like oxidative stress, activation of phospholipase system, microcirculatory disorders, hepatic dysfunction and hemostatic disorders, the severity of which is associated with the severity of pathology. The therapeutic effectiveness of basic treatment at early stages in patients with mild MJ was enough, while in patients with severe MJ not always. Conclusion. Supravascular quantum irradiation added to standard therapy in patients with severe mechanical jaundice promotes more rapid restoration of hepatic dysfunction and more effective correction of the homeostatic system.","PeriodicalId":10008,"journal":{"name":"Chinese Journal of Laser Medicine & Surgery","volume":"113 46","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72375929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-29DOI: 10.37895/2071-8004-2020-24-2-3-70-77
M. M. Mammеdov, E. Rustamov, R. Aliyev
Purpose. To study effects of intravenous laser blood irradiation (ILBI) with laser debridement of wounds and abdominal cavity, which are added to the standard laparoscopic and surgical treatment of perforated gastroduodenal ulcers. Material and methods . 31 patient with perforated gastroduodenal ulcers and symptoms of peritonitis were treated in the hospital. They were divided into two groups. In the control group (n = 19), after preoperative preparation patients were operated laparoscopically with suturing a perforated ulcer, sanitation and drainage of the abdominal cavity. In the main group (n = 12), after preoperative preparation, laparoscopic suturing of a perforated gastroduodenal ulcer in combination with ILBI, laser debridement of the wound and abdominal cavity were made. On admission, all patients were examined by the standard scheme: clinical examination, instrumental examinations (R-scan of chest, ultrasound examination of abdominal organs, electrocardiography, external respiration). To solve the task, the generally accepted clinical examination steps were added with biochemical testings (dynamics of changes in free radical lipid oxidation processes and in antioxidant blood protection parameters). Results. When treating patients with perforated gastroduodenal ulcers laparoscopically in combination with ILBI and laser debridement of wounds and the abdominal cavity, the researchers noted the following in the main group: better indices of average mass molecules (MSM), less blood intoxication, immunity increase – what, in its turn, leads to the increase in lipid peroxidation and antioxidant protection at the final stage of treatment. Such positive effects have decreased the number of postoperative complications as well as the average duration of treatment, if to compare with traditional care, thus ultimately, leading to less financial costs. Conclusion. The laparoscopic technique in combination with ILBI and laser wound and abdominal sanitation in patients with perforated gastroduodenal ulcers is a promising modality which has a high medical and social importance. surgery, intravenous laser blood irradiation, laser debridement of wounds and abdominal cavity.
{"title":"The effectiveness of laparoscopic technique in combination with laser irradiation in acute perforated gastroduodenal ulcers","authors":"M. M. Mammеdov, E. Rustamov, R. Aliyev","doi":"10.37895/2071-8004-2020-24-2-3-70-77","DOIUrl":"https://doi.org/10.37895/2071-8004-2020-24-2-3-70-77","url":null,"abstract":"Purpose. To study effects of intravenous laser blood irradiation (ILBI) with laser debridement of wounds and abdominal cavity, which are added to the standard laparoscopic and surgical treatment of perforated gastroduodenal ulcers. Material and methods . 31 patient with perforated gastroduodenal ulcers and symptoms of peritonitis were treated in the hospital. They were divided into two groups. In the control group (n = 19), after preoperative preparation patients were operated laparoscopically with suturing a perforated ulcer, sanitation and drainage of the abdominal cavity. In the main group (n = 12), after preoperative preparation, laparoscopic suturing of a perforated gastroduodenal ulcer in combination with ILBI, laser debridement of the wound and abdominal cavity were made. On admission, all patients were examined by the standard scheme: clinical examination, instrumental examinations (R-scan of chest, ultrasound examination of abdominal organs, electrocardiography, external respiration). To solve the task, the generally accepted clinical examination steps were added with biochemical testings (dynamics of changes in free radical lipid oxidation processes and in antioxidant blood protection parameters). Results. When treating patients with perforated gastroduodenal ulcers laparoscopically in combination with ILBI and laser debridement of wounds and the abdominal cavity, the researchers noted the following in the main group: better indices of average mass molecules (MSM), less blood intoxication, immunity increase – what, in its turn, leads to the increase in lipid peroxidation and antioxidant protection at the final stage of treatment. Such positive effects have decreased the number of postoperative complications as well as the average duration of treatment, if to compare with traditional care, thus ultimately, leading to less financial costs. Conclusion. The laparoscopic technique in combination with ILBI and laser wound and abdominal sanitation in patients with perforated gastroduodenal ulcers is a promising modality which has a high medical and social importance. surgery, intravenous laser blood irradiation, laser debridement of wounds and abdominal cavity.","PeriodicalId":10008,"journal":{"name":"Chinese Journal of Laser Medicine & Surgery","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88351153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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