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Retraction notice to “Treatment with 7-O-tetradecanoyl-genistein reduces IFN-γ and IL-17 levels in the brain and ameliorates clinical signs of experimental autoimmune encephalomyelitis” [Biomed. Prev. Nutr. 3 (2013) 26–30] “7- o -十四烷基染料木素治疗可降低脑内IFN-γ和IL-17水平,改善实验性自身免疫性脑脊髓炎的临床症状”的撤回通知[Biomed]。上一页。nur . 3 (2013) 26-30]
Pub Date : 2013-10-01 DOI: 10.1016/j.bionut.2013.08.001
Sandra B.R. Castro , Celso O. Rezende Junior , Caio C.S. Alves , Alyria T. Dias , Lívia L. Alves , Mauro V. Almeida , Maria Aparecida Juliano , Henrique C. Teixeira , Ana Paula Ferreira
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引用次数: 0
Retraction notice to: Direct effects of ursolic acid on oxidative phosphorylation of rat heart mitochondria [Biomed Prev Nutr (2012) 260–264] 撤回通告:熊果酸对大鼠心脏线粒体氧化磷酸化的直接影响[Biomed Prev Nutr (2012) 260-264]
Pub Date : 2013-10-01 DOI: 10.1016/j.bionut.2013.02.001
J. Liobikas , J. Bernatoniene , D. Majiene , L. Kursvietiene , R. Masteikova , D. Kopustinskiene , S. Trumbeckaite , A. Savickas
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引用次数: 0
Evaluation of Gelidiella acerosa, the red algae inhabiting South Indian coastal area for antioxidant and metal chelating potential 南印度沿海红藻尖胶藻的抗氧化和金属螯合能力评价
Pub Date : 2013-10-01 DOI: 10.1016/j.bionut.2013.03.007
N. Suganthy, S. Arif Nisha, S. Karutha Pandian, K. Pandima Devi

In vitro antioxidant potential and metal chelating activity of various solvent fractions of Gelidiella acerosa were evaluated by different antioxidant assays, like ferric reducing antioxidative power (FRAP) assay and scavenging activities for hydrogen peroxide, hydroxyl radical and nitric oxide. Among all the fractions, benzene showed the highest 1,1-diphenyl,2-picrylhydrazyl (DPPH) radical, nitric oxide and hydrogen peroxide scavenging activity when compared to standard BHT with IC50 values of 306.50 ± 3.04, 328.79 ± 14.25 and 275.43 ± 72.99 μg/mL, respectively. Total antioxidative capacity and reducing power was found to be significantly higher in the dichloromethane fraction. Highest ferrous ion chelating activity was observed in ethyl acetate and benzene fractions. Dimethylsulfoxide fraction exerted the highest hydroxyl radical scavenging effect. Moreover, benzene and dichloromethane fraction showed the highest total polyphenolic content of 18.86 ± 0.27 and 17.69 ± 0.353 μg/mg of dry extract, respectively. Preliminary cytotoxic studies suggest that benzene and dichloromethane fraction has no cytotoxic effect, hence, they can be used as effective antioxidant for treating reactive oxygen species (ROS) mediated diseases.

通过铁还原抗氧化能力(FRAP)、过氧化氢、羟基自由基和一氧化氮的清除能力等抗氧化指标,评价了不同溶剂组分的体外抗氧化能力和金属螯合活性。其中,苯与标准BHT相比,对1,1-二苯基、2-苦味肼基(DPPH)自由基、一氧化氮和过氧化氢的清除活性最高,IC50值分别为306.50±3.04、328.79±14.25和275.43±72.99 μg/mL。总抗氧化能力和还原能力在二氯甲烷馏分中显著提高。乙酸乙酯和苯馏分中铁离子螯合活性最高。二甲亚砜组分对羟基自由基的清除作用最强。其中,苯和二氯甲烷组分的总多酚含量最高,分别为18.86±0.27和17.69±0.353 μg/mg。初步的细胞毒性研究表明,苯和二氯甲烷组分没有细胞毒性作用,因此,它们可以作为有效的抗氧化剂治疗活性氧(ROS)介导的疾病。
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引用次数: 19
Phenolic acid-rich extract of sweet basil restores cholesterol and triglycerides metabolism in high fat diet-fed mice: A comparison with fenofibrate 甜罗勒酚酸丰富提取物恢复高脂肪饮食小鼠胆固醇和甘油三酯代谢:与非诺贝特的比较
Pub Date : 2013-10-01 DOI: 10.1016/j.bionut.2013.03.005
Hicham Harnafi , Mhamed Ramchoun , Mounique Tits , Jean-Noël Wauters , Michel Frederich , Luc Angenot , Mohammed Aziz , Chakib Alem , Souliman Amrani

Many spices are often added to foods as additives to enhance organoleptic qualities, such as flavor, aroma and color. Sweet basil (Ocimum basilicum L.) family of Lamiaceae is widely used in cooking for its culinary attributes. In this study, we aimed at the investigation of the hypocholesterolemic and hypotriglyceridemic activities of the basil phenolic acid-rich extract in high fat diet-induced hyperlipemic mice. Hyperlipemia was developed by a high fat diet containing cholesterol, lard and cholic acid. At the beginning of the experiment, animals were divided into three groups, one of them served as normolipidemic control group (NCG), the second hyperlipidemic control group (HCG) and the third basil-treated group (BTG). After 5 weeks of treatment, basil phenolic acid-rich extract significantly decreased plasma total cholesterol, triglycerides and LDL-cholesterol (−42%,−42% and −86%, respectively, P < 0.001). However, HDL-cholesterol was increased (+79%, P < 0.001). The extract reduced the atherogenic index and LDL/HDL-C ratio (−88% and −94%, respectively, P < 0.001). The reductions of liver total cholesterol and triglycerides were of −50% (P < 0.01) and −58% (P < 0.01), respectively. The hypolipemic effect of the phenolic acid-rich extract is comparable to that exerted by fenofibrate. This drug significantly reduced plasma total cholesterol, triglycerides and LDL-cholesterol (−25.5%, −51%, and −83.5%, respectively, P < 0.001) and increased plasma HDL-cholesterol (+136%, P < 0.001). On the other hand, fenofibrate significantly decreased atherogenic index and LDL/HDL-cholesterol ratio (−91% and −93%, respectively, P < 0.001). The fenofibrate decreased hepatic total cholesterol by 59.5% and triglycerides by 72%, respectively (P < 0.01). HPLC analysis led to identify four major compounds: caftaric acid, cafeic acid, chicoric acid and rosmarinic acid. In conclusion, the Sweet basil contains phenolic products that are able to lower hyperlipidemia and prevent atherosclerosis.

许多香料通常作为添加剂添加到食品中,以增强感官品质,如风味、香气和颜色。甜罗勒(Ocimum basilicum L.)科因其烹饪特性被广泛用于烹饪。在本研究中,我们旨在研究罗勒酚酸提取物对高脂肪饮食诱导的高脂血症小鼠的降胆固醇和降甘油三酯活性。高脂血症是由含有胆固醇、猪油和胆酸的高脂肪饮食引起的。实验开始时,将动物分为三组,其中一组为降脂对照组(NCG),第二组为高脂血症对照组(HCG),第三组为罗勒处理组(BTG)。治疗5周后,罗勒酚酸提取物显著降低血浆总胆固醇、甘油三酯和低密度脂蛋白胆固醇(分别为- 42%、- 42%和- 86%)。0.001)。然而,高密度脂蛋白胆固醇升高(+79%,P <0.001)。该提取物降低了动脉粥样硬化指数和LDL/HDL-C比值(分别为- 88%和- 94%);0.001)。肝脏总胆固醇和甘油三酯降低- 50% (P <0.01)和- 58% (P <分别为0.01)。富酚酸提取物的降血脂作用与非诺贝特相当。该药物显著降低血浆总胆固醇、甘油三酯和低密度脂蛋白胆固醇(分别为- 25.5%、- 51%和- 83.5%)。0.001)和血浆高密度脂蛋白胆固醇升高(+136%,P <0.001)。另一方面,非诺贝特显著降低动脉粥样硬化指数和LDL/ hdl -胆固醇比值(分别为- 91%和- 93%),P <0.001)。非诺贝特使肝脏总胆固醇降低59.5%,甘油三酯降低72% (P <0.01)。高效液相色谱分析鉴定出四种主要化合物:枸杞子酸、咖啡酸、菊苣酸和迷迭香酸。总之,甜罗勒含有酚类物质,能够降低高脂血症和预防动脉粥样硬化。
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引用次数: 28
Inhibition of preadipocyte differentiation and lipid accumulation by 7-O-galloyl-d-sedoheptulose treatment in 3T3-L1 adipocytes 7- o -没食子酰-d-糖庚糖对3T3-L1脂肪细胞前脂肪细胞分化和脂质积累的抑制作用
Pub Date : 2013-10-01 DOI: 10.1016/j.bionut.2013.03.012
Chan Hum Park , Dong Young Rhyu , Bhesh Raj Sharma , Takako Yokozawa

In this study, we investigated the effect of 7-O-galloyl-d-sedoheptulose (GS) on adipocyte differentiation in 3T3-L1 cells. GS significantly suppressed 3T3-L1 differentiation. The activation of adenosine monophosphate-activated protein kinase (AMPK) was demonstrated by measuring phosphorylation. In addition, GS down-regulated the adipogenesis-related protein expression of the sterol regulatory element-binding protein 1c. GS significantly reduced the protein expression of the peroxisome proliferator-activated receptor γ and of the CCAAT/enhancer-binding protein α, two key transcription factors in adipogenesis. These findings indicate that GS exerts anti-adipogenic activity via AMPK activation and may act to prevent obesity.

在本研究中,我们研究了7- o -没食子酰-d-sedoheptulose (GS)对3T3-L1细胞脂肪细胞分化的影响。GS显著抑制3T3-L1分化。腺苷单磷酸活化蛋白激酶(AMPK)的活化是通过测量磷酸化证实的。此外,GS还下调了脂肪形成相关蛋白中固醇调节元件结合蛋白1c的表达。GS显著降低了过氧化物酶体增殖物激活受体γ和CCAAT/增强子结合蛋白α的蛋白表达,这是脂肪形成的两个关键转录因子。这些发现表明,GS通过激活AMPK发挥抗脂肪生成活性,并可能起到预防肥胖的作用。
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引用次数: 11
Lactobacillus casei and Lactobacillus acidophilus attenuates the severity of experimental arthritis by regulating biochemical parameters 干酪乳杆菌和嗜酸乳杆菌通过调节生化参数减轻实验性关节炎的严重程度
Pub Date : 2013-10-01 DOI: 10.1016/j.bionut.2013.10.006
Sarika Amdekar , Purabi Roy , Vinod Singh , Avnish Kumar , Rambir Singh , Poonam Sharma

FCA induced arthritis was used to assess the antiarthritic activity of Lactobacillus casei and Lactobacillus acidophilus administered orally as preventive and therapeutic treatments as alone or in combination. Development of paw edema in the right hind limb was measured with a vernier caliper at the end of each week for 21 days. Animals were sacrificed on 22nd day and serum was taken to study various biochemical parameters. Knee joints were also taken for histopathology. Preventive and therapeutic Lactobacillus treatments significantly increased the serum albumin, total protein, alkaline and acid phosphatase and calcium levels of arthritic animals but decreased the (elevated) titers of rheumatoid factor, ceruloplasmin and serum phosphorous levels. Paw inflammation was also decreased by Lactobacillus in both preventive and therapeutic doses. The knee joint histopathologies of arthritic rats treated with Lactobacillus were also normalized. Lactobacillus exhibits protective properties in both preventive and therapeutic approaches.

FCA诱导的关节炎被用来评估干酪乳杆菌和嗜酸乳杆菌单独或联合口服作为预防和治疗治疗的抗关节炎活性。每周末用游标卡尺测量右后肢足跖水肿的发展情况,持续21天。第22天处死动物,取血清测定各项生化指标。同时取膝关节进行组织病理学检查。预防性和治疗性乳杆菌治疗显著提高关节炎动物血清白蛋白、总蛋白、碱性和酸性磷酸酶和钙水平,降低(升高)类风湿因子滴度、铜蓝蛋白滴度和血清磷水平。预防剂量和治疗剂量的乳酸杆菌也能减轻爪子炎症。乳酸杆菌治疗的关节炎大鼠的膝关节组织病理学也归一化。乳酸菌在预防和治疗两方面都具有保护作用。
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引用次数: 3
Effects of a peptide isolated from γ-casein hydrolysates on rat arterial blood pressure assay carried out under different anaesthetic drugs treatment γ-酪蛋白水解产物分离肽对不同麻醉药物处理下大鼠动脉血压的影响
Pub Date : 2013-10-01 DOI: 10.1016/j.bionut.2013.03.008
L.C.A.G. Chaguri, S.A. Barreto, I. Lebrun

The action of the peptide YPVQPFTE, isolated from the tryptic hydrolysate of γ-casein, displays a bradykinin potentiating activity, characterized by the arterial blood pressure recording analysis. The intravenous injection of bradykinin (0.5 μg) pre-treated with this peptide (30 μg) was performed by chronic assay in conscious spontaneously hypertensive rats (SHR) and also by acute assay in normotensive Wistar rats, anaesthetized by three currently used anaesthetic drugs: sodium pentobarbitone (68 mg/kg, i.p.); ketamine hydrochloride (25 mg/kg, i.p.) associated with xylazine hydrochloride (10 mg/kg, i.p.) and atropine (0,05 mg/Kg, i.p.); and chloral hydrate (160 mg/kg, i.p.). The peptide displayed bradykinin potentiating activity, by means that was not related to angiotensin converting enzyme (ACE) inhibition. The hypotensive areas were compared by two parameters, namely magnitude decrease (mmHg) and time course (min) to recover the pressure baseline values. In the first parameter, conscious SHR presented a greater decrease of the arterial blood pressure, followed by chloral hydrate and sodium pentobarbitone, ketamine–xylazine, which presented a small decrease. For the time parameter, the two depressants of the CNS presented the higher time to recover from the hypotension and ketamine–xylazine association resulted similar to conscious SHR group. The results demonstrated that the magnitude of the hypotension (mmHg) caused by the action of the vasoactive compounds was not directly altered by anaesthetic drugs even with compounds not related to ACE but the time to recover from this hypotension was significantly different depending on pharmacological mechanism proprieties of the anaesthetic agent used, suggesting that the main effects observed in this case is the failure to recover basal Mean Arterial Pressure (MAP) in the presence of depressant of the central nervous system.

从γ-酪蛋白的胰蛋白酶水解产物中分离出的肽YPVQPFTE的作用显示出缓激肽增强活性,其特征是动脉血压记录分析。采用三种常用麻醉药物:戊巴比妥钠(68 mg/kg, i.p.)麻醉,在有意识自发性高血压大鼠(SHR)和正常血压Wistar大鼠(30 μg)的慢性实验和急性实验中,静脉注射经该肽预处理的缓激肽(0.5 μg);盐酸氯胺酮(25mg /kg,口服)与盐酸噻嗪(10mg /kg,口服)和阿托品(0.05 mg/kg,口服)联合使用;水合氯醛(160mg /kg, i.p.)。该肽显示缓激肽增强活性,与血管紧张素转换酶(ACE)抑制无关。通过降压幅度(mmHg)和时间过程(min)两项参数比较血压恢复基线值。在第一个参数中,有意识SHR对动脉血压的降低幅度较大,其次是水合氯醛和戊巴比妥钠、氯胺酮-噻嗪,其降低幅度较小。在时间参数上,两种CNS抑制剂从低血压中恢复所需的时间均高于有意识SHR组,且氯胺酮-噻嗪联用效果与有意识SHR组相似。结果表明,由血管活性化合物作用引起的低血压(mmHg)的大小并没有被麻醉药物直接改变,即使是与ACE无关的化合物,但从这种低血压恢复的时间明显不同,这取决于所使用的麻醉药物的药理机制特性。这表明在这种情况下观察到的主要影响是在中枢神经系统抑制剂存在的情况下未能恢复基础平均动脉压(MAP)。
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引用次数: 0
Immobilization of hesperidin on stainless steel surfaces and its blood compatibility 橙皮苷在不锈钢表面的固定化及其血液相容性
Pub Date : 2013-10-01 DOI: 10.1016/j.bionut.2013.08.007
An J. Li

The coating of hesperidin, a traditional Chinese medicine ingredient, was immobilized to the surface of stainless steel (SS) which was often used in the cardiovascular implant materials and evaluated for its blood compatibility in vitro. The immobilized coating showed prolonged activated partial thromboplastin time (APTT), prothrombin time (PT) and thrombin time (TT) values compared with stainless steel control. The platelet adhesion and activation test on the hesperidin coating also showed significantly less data compared with the control. The test on conformational change of fibrinogen (fgn) demonstrated the hesperidin coating could reduce this parameter compared with the bare SS. It can be summarized that the hesperidin coating can effectively improve the blood compatibility of the SS surface. We envisage that this coating will provide a potential and effective selection for blood contact devices.

将中药橙皮苷包被固定在心血管植入材料常用的不锈钢表面,并对其体外血液相容性进行了评价。与不锈钢对照相比,固定化涂层的活化部分凝血活素时间(APTT)、凝血酶原时间(PT)和凝血酶时间(TT)均有所延长。橙皮苷涂层的血小板粘附和活化试验数据也明显少于对照组。纤维蛋白原(fgn)构象变化测试表明,与裸SS相比,橙皮苷包被可以降低该参数。可见,橙皮苷包被可以有效提高SS表面的血液相容性。我们设想这种涂层将为血液接触装置提供潜在和有效的选择。
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引用次数: 4
Protective role of coenzyme Q10, riboflavin, niacin, selenium (CoRNS) and Emblica officinalis on cardiac abnormalities in experimental atherosclerosis 辅酶Q10、核黄素、烟酸、硒和栓皮栎对实验性动脉粥样硬化心脏异常的保护作用
Pub Date : 2013-10-01 DOI: 10.1016/j.bionut.2013.03.010
Umapathi Indumathi, Karvannan Kanchana, Panchanatham Sachdanandam

Atherosclerosis is characterized by the deposition of lipids in the artery wall and the infiltration of inflammatory cells, such as monocytes and lymphocytes. Hyperlipidemia is a major risk factor for the premature development of atherosclerosis and it has been shown to increase the incidence of myocardial ischemia and cardiac events. The aim of the present study is to evaluate the hypolipidemic and cardioprotective effect of CoQ10, riboflavin, niacin, selenium (CoRNS), and Emblica officinalis (Amla) in male wistar albino rats fed with high cholesterol diet (HCD) comprising of the normal chow supplemented with 4% cholesterol, 1% cholic acid for 30 days to develop atherosclerosis. After 30 days, Group IV animals were treated with Simvastatin as standard drug and Group V animals were treated with CoRNS and Amla. All the drugs were given by oral gavage for 30 days. Group III animals were served as drug control. Atherosclerosis was confirmed by disturbances in plasma and cardiac marker enzymes such as lactate dehydrogenase (LDH), aspartate transaminase (AST), alanine transaminase (ALT), and alkaline phosphatase (ALP), increased levels of plasma lipoproteins like VLDL, LDL and decrease in HDL and increased levels of plasma lipids like triglycerides (TG), phospholipids (PL), free fatty acids (FFA) and cholesterol (CHO). There was significant increase in lipid peroxidation (LPO) and decreased activity of antioxidant enzymes such as SOD, CAT and GPx and also diminished levels of vitamin C, vitamin E and GSH. Treatment with CoRNS and Amla maintained the levels of marker enzymes, lipoproteins, lipids and also the antioxidants to near normal thereby proving its hypolipidemic and cardioprotective properties.

动脉粥样硬化的特点是脂质在动脉壁沉积,炎症细胞如单核细胞和淋巴细胞浸润。高脂血症是动脉粥样硬化过早发展的主要危险因素,它已被证明会增加心肌缺血和心脏事件的发生率。本研究的目的是评估CoQ10、核黄素、烟酸、硒(CoRNS)和Emblica officinalis (Amla)对雄性wistar白化大鼠的降血脂和心脏保护作用,这些大鼠在高胆固醇饮食(HCD)的基础上添加4%的胆固醇和1%的胆酸,持续30天导致动脉粥样硬化。30 d后,IV组以辛伐他汀为标准药物治疗,V组以CoRNS和Amla治疗。所有药物均灌胃给药30 d。第三组动物作为药物对照。动脉粥样硬化通过血浆和心脏标记酶如乳酸脱氢酶(LDH)、天冬氨酸转氨酶(AST)、丙氨酸转氨酶(ALT)和碱性磷酸酶(ALP)的紊乱,血浆脂蛋白如VLDL、LDL水平升高,HDL水平降低,血浆脂质如甘油三酯(TG)、磷脂(PL)、游离脂肪酸(FFA)和胆固醇(CHO)水平升高来证实。脂质过氧化(LPO)升高,SOD、CAT和GPx等抗氧化酶活性降低,维生素C、维生素E和GSH水平降低。用CoRNS和Amla治疗后,标记酶、脂蛋白、脂质和抗氧化剂的水平保持在接近正常水平,从而证明了其降血脂和心脏保护特性。
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引用次数: 4
Effect of diosgenin on cardiac tissue lipids, trace elements, molecular changes, TNF-α and IL-6 expression in CRF rats 薯蓣皂苷元对CRF大鼠心脏组织脂质、微量元素、分子变化及TNF-α、IL-6表达的影响
Pub Date : 2013-10-01 DOI: 10.1016/j.bionut.2013.08.005
Jeganathan Manivannan, Janakiraman Shanthakumar, Krishnamoorthy Rajeshwaran, Pandiyan Arunagiri, Elumalai Balamurugan

The aim of the present study was to evaluate the effect of diosgenin a proven antioxidant on chronic renal failure (CRF) induced abnormalities linked with oxidative stress in heart. CRF was induced in male Wistar rats by feeding the animals with 0.75% adenine-containing diet and diosgenin was given orally (everyday at the dose of 40 mg/kg). Effect of diosgenin on cardiac tissue lipids, trace elements (iron, zinc, magnesium, copper and manganese) and activity of cardiac mitochondrial enzymes were assayed. Expression of tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) was also assessed. The Fourier transform infrared spectroscopy (FTIR) analysis was employed to indicate the oxidative stress related molecular changes in heart tissue. The outcomes of the study indicated that, diosgenin reduces the tissue lipid abnormalities induced by CRF. Cardiac elemental concentration was not changed in all groups but the plasma zinc was altered and diosgenin have no effect on it. Cardiac mitochondrial enzymes abnormalities and proinflammatory cytokines expression was also significantly reduced by diosgenin. Finally, the molecular and structural changes of proteins were also reduced by diosgenin treatment. The overall study shows that diosgenin with antioxidant function have enough potential to improve cardiac tissue abnormalities.

本研究的目的是评估薯蓣皂苷元(一种已证实的抗氧化剂)对慢性肾功能衰竭(CRF)引起的心脏氧化应激异常的影响。用含0.75%腺嘌呤的饲粮喂养雄性Wistar大鼠,并口服薯蓣皂苷元(每天40 mg/kg)诱导CRF。测定薯蓣皂苷元对心肌组织脂质、微量元素(铁、锌、镁、铜、锰)及心肌线粒体酶活性的影响。同时检测肿瘤坏死因子α (TNF-α)和白细胞介素6 (IL-6)的表达。采用傅里叶变换红外光谱(FTIR)分析心脏组织中氧化应激相关的分子变化。研究结果表明,薯蓣皂苷元可减轻CRF引起的组织脂质异常。各组心脏元素浓度均无变化,血浆锌有改变,薯蓣皂苷元对其无影响。心肌线粒体酶异常和促炎细胞因子表达也显著降低。最后,薯蓣皂苷元还降低了蛋白质的分子和结构变化。综上所述,具有抗氧化功能的薯蓣皂苷元具有改善心脏组织异常的潜力。
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引用次数: 6
期刊
Biomedicine & Preventive Nutrition
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