Chemical Engineering Research & Design最新文献_第10页

Mathematical modeling of binary gas mixture adsorption at low pressures for high-throughput gas laser systems 高通量气体激光系统低压下二元气体混合物吸附的数学建模

IF 3.9 3区工程技术 Q2 ENGINEERING, CHEMICAL

Chemical Engineering Research & Design

Pub Date : 2025-12-22 DOI: 10.1016/j.cherd.2025.12.032

Akshayy Garg, Sanjeev Kumar, Gaurav Singhal, Jagannath Nayak

Gas laser systems like COIL (Chemical Oxygen Iodine Laser) operate at low exhaust pressures of 1–20 torr. Such systems require large amounts of gas removal (∼kg/s) for laser power levels of hundreds of kilowatts) at a fast rate from the system. Analytical modeling of high-throughput systems (flow rates in g/s) at low pressures is critical in developing compact adsorption-based vacuum systems. Low-throughput systems (flow rates in μg/s), utilized to provide ultra-low vacuum, where equilibrium conditions are achieved almost instantaneously. High-throughput adsorption beds exhibit a dynamic behavior similar to a lumped mass system due to dynamic change in pump pressure and bed utilization. The article establishes an analytical model for the binary adsorption of gases (nitrogen-oxygen) at low temperatures and pressures for high-throughput adsorption-based vacuum systems, which are dependent on adsorption equilibrium conditions, pump pressure, concentration of species and temperature of bed. Pure species equilibrium model is established with RMSE less than 3.28 % for nitrogen and 8.50 % for oxygen. The binary adsorption equilibrium is modeled using the Ideal Adsorption Solution (Meyer Prausnitz) model. A comprehensive analytical model is developed to model the dynamic behavior of a high-throughput multi-species system. The model incorporates developed equilibrium models and fitting of empirical relation for experimental multi-layer absorptivity adsorption bed. The RMSE is less than 15.76 % from experimental reported data for multi-cycle testing at 0.23 mol/s air flow rate. The dynamic behavior of the scaled-up bed is also investigated for 10 kW COIL operation (1.7 mols/s exhaust gas) for 5 s, predicting an adsorption pressure rise of less than 12 torr in agreement with experimental data.

气体激光系统，如COIL（化学氧碘激光器）在1-20 torr的低排气压力下工作。这样的系统需要大量的气体以快速的速率从系统中去除（~ kg/s），用于数百千瓦的激光功率水平。低压下高通量系统（以g/s为单位的流量）的分析建模对于开发紧凑型吸附真空系统至关重要。低通量系统（流量单位为μg/s），用于提供超低真空，几乎可以立即达到平衡条件。由于泵压力和床层利用率的动态变化，高通量吸附床表现出类似于集总质量系统的动态行为。本文建立了基于高通量吸附的真空系统在低温和低压下气体（氮-氧）二元吸附的解析模型，该模型依赖于吸附平衡条件、泵压力、物质浓度和床层温度。建立了纯物种平衡模型，氮的RMSE小于3.28 %，氧的RMSE小于8.50 %。二元吸附平衡采用理想吸附溶液（Meyer Prausnitz）模型进行建模。建立了一个综合的分析模型来模拟高通量多物种系统的动态行为。该模型结合了已开发的平衡模型和实验多层吸附床的经验关系拟合。在0.23 mol/s空气流速下，多循环测试的RMSE小于15.76 %。在10 kW COIL （1.7 mol /s废气）运行5 s的情况下，对放大床的动态行为进行了研究，预测吸附压力上升小于12 torr，与实验数据一致。

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引用次数: 0

Polymeric nanocapsules loaded with ampicillin using subcritical water-based solvent-antisolvent method 亚临界水基溶剂-抗溶剂法制备氨苄西林聚合物纳米胶囊

IF 3.9 3区工程技术 Q2 ENGINEERING, CHEMICAL

Chemical Engineering Research & Design

Pub Date : 2025-12-20 DOI: 10.1016/j.cherd.2025.12.034

Mohsen Najafi, Ali Haghighi Asl, Mohammad Nader Lotfollahi, Maryam Khajenoori

Ampicillin trihydrate-loaded nanocapsules were synthesized and characterized to evaluate their drug delivery, release profile, and potential bioavailability. A green preparation encapsulation technique based on the solvent–anti-solvent method was employed, where subcritical water (100–120 °C) and cold water (0–20 °C) were utilized as the solvent and the anti-solvent, respectively. This environmentally friendly approach facilitated the formation of nanoparticles using polylactic acid as the biodegradable coating polymer. The influence of three key variables including subcritical solvent temperature (100, 110, 120 °C), anti-solvent temperature (0, 10, 20 °C), and polymer weight percent (w/w%) (10 %, 15 %, 20 %), was systematically investigated on the drug loading efficiency and particle size. Findings revealed that nanoparticle size increased with enhancing the polymer w/w% and anti-solvent temperature, but decreased as the solvent temperature was increased. Optimal conditions (120 °C solvent, 0 °C anti-solvent, 10 % polymer) yielded spherical nanoparticles with a mean diameter of 200 nm. These results suggest effective drug encapsulation and controlled release, highlighting the method’s promise for enhanced bioavailability in drug delivery systems.

合成了三水合氨苄西林纳米胶囊，并对其进行了表征，以评估其给药、释放特征和潜在的生物利用度。采用基于溶剂-抗溶剂法的绿色制备包封技术，以亚临界水（100-120℃）和冷水（0-20℃）分别作为溶剂和抗溶剂。这种环境友好的方法促进了纳米颗粒的形成，使用聚乳酸作为可生物降解的涂层聚合物。系统考察了亚临界溶剂温度（100、110、120℃）、抗溶剂温度（0、10、20℃）和聚合物质量百分比（w/w%）（10 %、15 %、20 %）对载药效率和粒径的影响。结果表明，纳米颗粒尺寸随聚合物w/w%和抗溶剂温度的升高而增大，随溶剂温度的升高而减小。最佳条件（120°C溶剂，0°C抗溶剂，10 %聚合物）得到平均直径为200 nm的球形纳米颗粒。这些结果表明有效的药物包封和控释，突出了该方法在药物传递系统中提高生物利用度的前景。

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引用次数: 0

Layer-by-layer coating of silibinin-loaded cochleates with chitosan and alginate for enhanced oral delivery 壳聚糖和海藻酸盐层涂覆水飞蓟宾酸酯以增强口服给药

IF 3.9 3区工程技术 Q2 ENGINEERING, CHEMICAL

Chemical Engineering Research & Design

Pub Date : 2025-12-16 DOI: 10.1016/j.cherd.2025.12.029

Nishtha Thakur, Zaher Judeh

The oral bioavailability of silibinin (SLB), a flavonoid from milk thistle, is limited by poor solubility and low gastrointestinal absorption. This study presents an efficient oral delivery system for SLB using lipid-based cochleates coated with chitosan (CH) and sodium alginate (SA) through a layer-by-layer approach. SLB-loaded cochleates were prepared at pH 6.0 and 7.4 with varying lipid-to-SLB ratios and characterized for morphology, encapsulation efficiency, and physicochemical properties. Cochleates at pH 7.4 showed superior encapsulation (99 %) and stability over pH 6.0. Optimized CH/SA coatings enhanced stability, reduced SLB leakage, and enabled controlled release. In-vitro studies showed SA/CH-coated cochleates minimized SLB release in gastric fluid, sustaining it in intestinal conditions. Stability studies confirmed the coatings' protective effect, retaining 97.84 % of SLB after 12 weeks at 4°C. These findings suggest SA/CH-coated cochleates as a promising platform for oral delivery of poorly soluble bioactives like SLB.

水飞蓟宾（SLB）是一种从水飞蓟中提取的类黄酮，它的口服生物利用度受溶解度差和胃肠道吸收低的限制。本研究采用壳聚糖（CH）和海藻酸钠（SA）包覆脂基耳蜗酸酯，通过逐层给药的方法，建立了一种高效的口服SLB给药系统。在pH 6.0和7.4条件下制备了负载slb的蜗状体，其脂质与slb的比例不同，并对其形态、包封效率和理化性质进行了表征。在pH 7.4时，Cochleates表现出良好的包封性（99% %），在pH 6.0时表现出稳定性。优化后的CH/SA涂层增强了稳定性，减少了SLB泄漏，并实现了可控释放。体外研究表明，SA/ ch包被的耳蜗可减少胃液中SLB的释放，在肠道条件下维持其释放。稳定性研究证实了涂层的保护作用，在4°C下加热12周后，涂层保留了97.84 %的SLB。这些研究结果表明，SA/ ch包被的耳蜗酸盐是口服递送SLB等难溶性生物活性物质的有希望的平台。

引用次数: 0

Porous liquid ZIF-67-integrated PDMS mixed matrix membranes for efficient bioethanol dehydration 多孔液体zif -67集成PDMS混合基质膜高效生物乙醇脱水

IF 3.9 3区工程技术 Q2 ENGINEERING, CHEMICAL

Chemical Engineering Research & Design

Pub Date : 2025-12-16 DOI: 10.1016/j.cherd.2025.12.031

Hira Naveed , Asim Laeeq Khan , Muhammad Yasin , Mazhar Amjad Gilani , Babar Saeed , Muhammad Usman , Muhammad Aslam , Aftab Ahmad Khan , Hamad AlMohamadi , Faisal O. Mahroogi

Energy efficient dehydration of fermentation broths is a critical bottleneck in bioethanol production, where conventional distillation imposes a high thermal and carbon penalty. Pervaporation using polymer–inorganic hybrid membranes offers a promising low-energy alternative, provided that membrane exhibits both high flux and selectivity to alcohols. Here, we demonstrate that incorporating a porous liquid (PL) form of ZIF-67 into polydimethylsiloxane (PDMS) mixed matrix membranes (MMMs) enables simultaneously high flux and selectivity for ethanol dehydration via pervaporation. ZIF-67 crystals were first synthesized and then converted into a Type-3 porous liquid through N-heterocyclic carbene functionalization and dispersion in mesitylene, yielding a flowable, solution-processable MOF phase. This PL was incorporated into PDMS at loadings up to 40 wt% without aggregation or interfacial defects, overcoming the dispersion and compatibility limitations typically observed with solid MOF fillers. Pervaporation tests using a 6 wt% ethanol/water feed showed that the 40 wt% ZIF-67-PL membrane achieved a total flux of 3.5 kg·m⁻²·h⁻¹ and a separation factor of 19.8 at 65 °C, corresponding to approximately a 170 % increase in flux and a 205 % enhancement in separation factor compared to pristine PDMS. Benchmarking against state-of-the-art PDMS-based MMMs highlights ZIF-67-PL/PDMS membranes as a high-performance, scalable platform for bioethanol dehydration and, more broadly, for next-generation porous-liquid-enabled separations.

高效脱水的发酵液是生物乙醇生产的一个关键瓶颈，其中传统蒸馏施加了高热和碳惩罚。聚合物-无机杂化膜的渗透汽化是一种很有前途的低能量替代方法，前提是膜对醇具有高通量和选择性。在这里，我们证明了将多孔液体（PL）形式的ZIF-67结合到聚二甲基硅氧烷（PDMS）混合基质膜（MMMs）中，可以同时通过渗透蒸发实现乙醇脱水的高通量和选择性。首先合成了ZIF-67晶体，然后通过n-杂环碳烷的功能化和在亚三甲苯中的分散转化为3型多孔液体，得到了可流动、可溶液加工的MOF相。该PL被加入到PDMS中，负载高达40 wt%，没有聚集或界面缺陷，克服了通常在固体MOF填料中观察到的分散和相容性限制。使用6 wt%乙醇/水的渗透汽化试验表明，40 wt%的ZIF-67-PL膜的总通量为3.5 kg·m⁻²·h⁻¹ ，在65°C时的分离系数为19.8，与原始PDMS相比，通量增加了约170 %，分离系数增加了205 %。ZIF-67-PL/PDMS膜是一种高性能、可扩展的生物乙醇脱水平台，更广泛地说，可用于下一代多孔液体分离。

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引用次数: 0

Modelling and optimization of vacuum pressure swing adsorption CO2 capture pilot using MIL-160(Al) MIL-160（Al）真空变压吸附CO2捕集中试装置的建模与优化

IF 3.9 3区工程技术 Q2 ENGINEERING, CHEMICAL

Chemical Engineering Research & Design

Pub Date : 2025-12-16 DOI: 10.1016/j.cherd.2025.12.030

A. Henrotin, N. Heymans, M.-E. Duprez, G. De Weireld

Global warming, driven by increasing CO₂ emissions from fossil fuel combustion, necessitates the development of effective carbon capture technologies. Among various approaches, Vacuum Pressure Swing Adsorption (VPSA) offers an energy-efficient solution for post-combustion CO₂ capture, especially in power plants and energy-intensive industries. This work focuses on validating a simulation model using a laboratory VPSA pilot with the Aluminum Metal-Organic Framework (Al-MOF) MIL-160(Al) and optimizing both lab-scale and industrial-scale VPSA pilots through simulation. Process modeling in Aspen Adsorption software simulated a 3-bed 6-step cycle using parameters from experimental adsorption isotherms and breakthrough curves. The simulation model was compared to previous lab-scale VPSA pilot experiments treating a synthetic 15/85 CO₂/N₂ mixture at 1 Nm³ /h, showing mean absolute errors of 1.47 % for purity and 3.19 % for recovery. Surrogate models, including kriging and artificial neural networks (ANN), were used to optimize recovery and purity of the lab-scale pilot using the Non-dominated Sorting Genetic Algorithm-II (NSGA-II). The ANN model proved more accurate, especially in determining pareto fronts. The model was extended to an industrial VPSA pilot as part of the MOF4AIR project, designed to treat flue gas of 50–100 Nm³ /h with three 41 L adsorption columns. Simulations showed that the pilot could achieve 95 % purity and recovery for CO₂ concentrations ranging from 5 % to 15 %. The estimated energy consumption and productivity for 15 % CO₂ gas were 413.19 kWh/tCO₂ and 3.03 tCO₂/(m³ads.day) at a gas flow rate of 55.62 Nm³ /h, demonstrating the technology's potential and competitiveness on a larger scale.

由于化石燃料燃烧产生的二氧化碳排放量增加，全球变暖要求开发有效的碳捕获技术。在各种方法中，真空变压吸附（VPSA）为燃烧后的二氧化碳捕获提供了一种节能的解决方案，特别是在发电厂和能源密集型行业。这项工作的重点是使用铝金属有机框架（Al- mof） MIL-160（Al）验证实验室VPSA试点的模拟模型，并通过模拟优化实验室规模和工业规模的VPSA试点。Aspen吸附软件中的过程建模利用实验吸附等温线和突破曲线的参数模拟了3层6步循环。模拟模型与先前实验室规模的VPSA中试实验进行了比较，以1 Nm³ /h处理合成15/85 CO2/N2混合物，纯度的平均绝对误差为1.47 %，回收率的平均绝对误差为3.19 %。采用非支配排序遗传算法- ii (NSGA-II)，采用kriging和人工神经网络（ANN）等替代模型优化实验室规模中试的回收率和纯度。人工神经网络模型被证明更准确，特别是在确定帕累托前沿方面。作为MOF4AIR项目的一部分，该模型已扩展到工业VPSA试点，旨在使用三个41 L吸附塔处理50-100 Nm³ /h的烟气。模拟结果表明，该中试装置可以达到95% %的纯度和回收率，CO2浓度范围为5 %至15 %。15% % CO2气体的估计能耗和生产率分别为413.19 kWh/tCO2和3.03 tCO2/（m³ads）。天)，气体流速为55.62 Nm³ /h，证明了该技术在更大规模上的潜力和竞争力。

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引用次数: 0

Process modelling and analysis of ikaite production for atmospheric CO2 removal through ocean alkalinity enhancement 通过提高海洋碱度去除大气CO2的艾克煤生产过程模拟与分析

IF 3.9 3区工程技术 Q2 ENGINEERING, CHEMICAL

Chemical Engineering Research & Design

Pub Date : 2025-12-13 DOI: 10.1016/j.cherd.2025.12.028

Xuesong Lu , Rachel Millar , Pranav Toutam , Aidong Yang , Spyros Foteinis , Laura Bastianini , Phil Renforth , Stefan Baltruschat , Jens Hartmann

The production of ikaite, a metastable calcium carbonate hydrate, offers a promising pathway for atmospheric CO₂ removal through ocean alkalinity enhancement. This study explores the feasibility of ikaite production through a three-step process, involving calcite (CaCO₃) dissolution under elevated CO₂ pressure, CO₂ degassing from the calcium carbonate rich solution, and subsequent crystallisation. Here, a mathematical model was developed and validated against experimental data, and the effect of key operational parameters was examined. The calcite loading/dosage, particle size and CO₂ pressure for dissolution, seed loading and particle size for crystallisation, and degassing pressure as critical factors have significant impact on process efficiencies. Under optimal conditions, involving CO₂ pressures of 2 bar for dissolution, 0.01 bar for degassing, and 0.001 bar for crystallisation, with seed loading of 5 kg/m³ and seed particle sizes of 3 μm, the process achieved steady state ikaite production of 1.64 kg/m³ from a calcite feed of 0.83 kg/m³ . This investigation demonstrates the technical viability of ikaite production through CO₂ pressure swing and informs its future development as a potential contributor to climate change mitigation.

钙钛矿是一种亚稳定的碳酸钙水合物，它的产生为通过增强海洋碱度来去除大气中的二氧化碳提供了一条有前途的途径。本研究探索了通过三步工艺生产钙钛矿的可行性，包括在升高的CO2压力下溶解方解石（CaCO3），从富含碳酸钙的溶液中脱气CO2，然后结晶。在此基础上，建立了数学模型，并对实验数据进行了验证，考察了关键操作参数的影响。方解石的装载量/用量、用于溶解的颗粒大小和CO2压力、用于结晶的种子装载量和颗粒大小以及脱气压力是影响工艺效率的关键因素。在最优条件下,包括二氧化碳的压力2 酒吧解散,0.01 酒吧脱气,和0.001 酒吧结晶,种子装入5 公斤/ m³ 和种子粒径3μm, 1.64的生产过程达到稳态ikaite 公斤/ m³ 从方解石 0.83公斤饲料/ m³ 。这项调查证明了通过二氧化碳压力变化生产煤的技术可行性，并为其作为减缓气候变化的潜在贡献者的未来发展提供了信息。

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引用次数: 0

Improvement of the lubrication force modelling during normal particle collisions on wet surfaces considering the liquid layer height and inertial effects 考虑液层高度和惯性效应的湿表面正常颗粒碰撞润滑力模型的改进

IF 3.9 3区工程技术 Q2 ENGINEERING, CHEMICAL

Chemical Engineering Research & Design

Pub Date : 2025-12-12 DOI: 10.1016/j.cherd.2025.12.026

David Strohner, Sergiy Antonyuk

An accurate description of the lubrication force is essential for the modelling of liquid bridges in particulate processes involving fluids using the Discrete Element Method (DEM). However, common liquid bridge models often neglect the influence of the liquid layer height. In this study, the influence of layer height on the lubrication force was investigated through experiments and resolved Computational Fluid Dynamics (CFD) simulations. Various existing models for the lubrication force during the impact in normal direction on a wall covered by a liquid layer were evaluated based on their prediction of the energy dissipation for different layer heights. The influence of capillary effects during the particle penetration into the liquid layer was analysed depending on the capillary number emphasizing the importance of the lubrication force. Furthermore, simulations at particle Reynolds numbers greater than one revealed that inertial effects cause the actual lubrication force to surpass predictions made by conventional models applied in DEM. By the application of a machine learning approach, an improved lubrication force model is derived that incorporates an inertial term, extending its validity up to particle Reynolds numbers of 10,000.

使用离散元法（DEM）对涉及流体的颗粒过程中的液体桥进行建模，润滑力的准确描述是必不可少的。然而，常用的液桥模型往往忽略了液层高度的影响。本研究通过实验和计算流体动力学（CFD）模拟，研究了层高对润滑力的影响。基于对不同液层高度下的能量耗散的预测，对现有的各种液层覆盖壁面法向冲击润滑力模型进行了评价。在强调润滑力重要性的情况下，根据毛细数分析了颗粒渗透到液层过程中毛细效应的影响。此外，在粒子雷诺数大于1时的模拟表明，惯性效应导致实际润滑力超过了应用于DEM的传统模型的预测。通过应用机器学习方法，导出了包含惯性项的改进润滑力模型，将其有效性扩展到颗粒雷诺数为10,000。

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引用次数: 0

High-reactivity and high-strength coke promoted by heterogeneous core-shell binary structure 非均相核壳二元结构促进了焦炭的高活性和高强度

IF 3.9 3区工程技术 Q2 ENGINEERING, CHEMICAL

Chemical Engineering Research & Design

Pub Date : 2025-12-12 DOI: 10.1016/j.cherd.2025.12.027

Yang Liu, Yuqiang Fan, Xiangyun Zhong, Chao Li, Yanting Qu, Yang Liu, Shaoyan Wang, Jinfeng Bai

The introduction of hydrogen in hydrogen-rich blast furnaces reduces the temperature of the blast furnace system and negatively impacts the reduction rate of coke. The internal structure of coke is damaged, which makes it challenging to maintain thermal strength. Therefore, the preparation of high-reactivity and high-strength coke is of great significance for industry development and energy-saving carbon reduction. The strength of coke is enhanced by using briquettes made from strong caking coal as the core. Meanwhile, high-activity low-rank coal serves as the shell to enhance the reactivity of coke. The skeleton strength, dissolution rate and kinetic analysis of coke were investigated. Compared with conventional coke, the reactivity of the prepared coke increased by 1.1 %, while coke strength after reaction (CSR) was 3.1 %, with the interfacial reaction rate of high-temperature carbon dissolution improved. Additionally, the stacking number of aromatic layers and the ordering degree of the molecular structure have been enhanced. As the proportion of the core structure increased, the reactivity and high-temperature dissolution rate of coke decreased. Compared to industrial coke, coke with a heterogeneous core-shell binary structure can reduce the proportion of primary coking coal by 10 %, thereby lowering the production cost of enterprises.

富氢高炉引入氢气，降低了高炉系统温度，对焦炭还原率产生负面影响。焦炭的内部结构被破坏，使其难以保持热强度。因此，制备高反应性、高强度焦炭对工业发展和节能减碳具有重要意义。用强结块煤制成的型煤作芯，可提高焦炭的强度。同时，用高活性低阶煤作壳，提高焦炭的反应性。研究了焦炭的骨架强度、溶解速率和动力学分析。与常规焦炭相比，制备的焦炭反应活性提高了1.1 %，反应后焦炭强度（CSR）提高了3.1 %，高温溶碳界面反应速率提高。此外，芳香层的堆叠数和分子结构的有序度也得到了提高。随着炭芯结构比例的增加，焦炭的反应性和高温溶解速率降低。与工业焦炭相比，采用非均相核壳二元结构的焦炭可使一次炼焦煤的比例降低10 %，从而降低企业的生产成本。

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引用次数: 0

Spatial characteristics of turbulence induced by a pair of horizontally oscillating grids: A large eddy simulation study 一对水平振荡网格引起的湍流空间特征：大涡模拟研究

IF 3.9 3区工程技术 Q2 ENGINEERING, CHEMICAL

Chemical Engineering Research & Design

Pub Date : 2025-12-11 DOI: 10.1016/j.cherd.2025.12.022

Zhixin Sun , Xiaoheng Li , Bingyu Chen , Xiaokang Yan , Lijun Wang , Lin Li , Haijun Zhang

Isotropic turbulence plays a fundamental role in turbulence research and helps to understand more complex turbulent flows. Oscillating grid is a commonly used method for generating nearly uniform and isotropic turbulence in experimental research. However, the factors that govern the extent of the isotropic region remain uncertain, and discrepancies persist among the predictive correlations for the effective turbulence intensity. In this study, Large Eddy Simulation was conducted to examine the spatial characteristics of turbulence generated by a pair of horizontally oscillating grids. The effects of spatial position, oscillation amplitude, and frequency on the turbulent kinetic energy spectrum, dissipation rate, and effective turbulence intensity were systematically analyzed. Furthermore, the influence of energy input variations on turbulence intensity was investigated, and a modified correlation for effective turbulence intensity applicable to this configuration was proposed. This work provides a numerical framework for studying oscillating-grid turbulence and offers practical guidance for the structural design and optimization of grid configurations.

各向同性湍流在湍流研究中起着重要的作用，有助于理解更复杂的湍流。振荡网格是实验研究中常用的一种产生近均匀和各向同性湍流的方法。然而，控制各向同性区域范围的因素仍然不确定，有效湍流强度的预测相关性之间的差异仍然存在。本文采用大涡模拟的方法研究了一对水平振荡网格所产生的湍流的空间特征。系统分析了空间位置、振荡幅值和频率对湍流动能谱、耗散率和有效湍流强度的影响。此外，研究了能量输入变化对湍流强度的影响，并提出了适用于该构型的有效湍流强度的修正相关性。该工作为研究振荡网格湍流提供了一个数值框架，并为网格结构设计和优化提供了实用指导。

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引用次数: 0

Punch-based structural design strategies for controlled dispersion in paper assays 基于冲孔的结构设计策略控制纸张分析中的分散

IF 3.9 3区工程技术 Q2 ENGINEERING, CHEMICAL

Chemical Engineering Research & Design

Pub Date : 2025-12-11 DOI: 10.1016/j.cherd.2025.12.025

Chandra Bhushan , Devanshi Sharma , Debayan Das

Cellulose-based paper assays are attractive as low-cost, sustainable diagnostic platforms but are frequently hampered by uncontrolled hydrodynamic dispersion that degrades analyte confinement and lowers detection fidelity. Reducing dispersion is therefore essential to improve sensitivity and reliable readout in resource-constrained settings. Here, we demonstrate a simple, reagent-free strategy based on punch-induced geometric patterning: circular and segmented cuts that disrupt capillary continuity and suppress lateral spreading in cellulose membranes. Four commercial papers (Filter-Paper 113, 441, 442, and Ashless) were systematically tested under controlled hydration using a thymolphthalein-NaOH colorimetric model. Quantitative image analysis shows that at full saturation, circular cuts reduce dispersion by ∼15–60 % relative to unmodified membranes, whereas segmented cuts achieve substantially higher reductions, reaching ∼80–90 % in 442 and Ashless paper membranes and ∼20–40 % in 113 and 441 membranes. These results highlight that segmented cuts provide robust dispersion control even under maximum hydration, where conventional designs typically fail. Mechanistic interpretation suggests that the segmented geometry increases local hydraulic resistance in lateral pathways, sharpening colorimetric peaks and enhancing signal-to-background ratio. Importantly, the purely physical modification enables consistent reagent stabilization through simple oven drying under controlled conditions, offering a practical alternative to lyophilization for small-scale fabrication and resource-limited settings. Finally, the findings open a practical pathway for extending geometric patterning to multiplex detection layouts (two-, four-, six-, or eight-hole configurations), where precise spot localization and minimization of signal overlap are essential for reliable multi-analyte assays. This approach offers a low-cost, manufacturable route to more robust paper-based diagnostics.

纤维素纸检测作为低成本、可持续的诊断平台具有吸引力，但经常受到不受控制的水动力分散的阻碍，这会降低分析物的限制，降低检测的保真度。因此，在资源有限的环境中，减少色散对于提高灵敏度和可靠读数至关重要。在这里，我们展示了一种简单的，基于打孔诱导的几何图案的无试剂策略：圆形和分段切割，破坏毛细管连续性，抑制纤维素膜的横向扩散。四种商业纸（滤纸113、441、442和Ashless）在控制水合作用下使用百里苯-氢氧化钠比色模型进行系统测试。定量图像分析表明，在完全饱和时，圆形切割相对于未修饰的膜降低分散度约15-60 %，而分段切割的降低率更高，在442和无灰纸膜中达到约80-90 %，在113和441膜中达到约20-40 %。这些结果表明，即使在最大水化作用下，分段切割也能提供强大的分散控制，而传统设计通常无法做到这一点。机制解释表明，分割的几何形状增加了横向通道的局部水力阻力，使比色峰变得锐利，并增强了信本比。重要的是，纯物理改性可以在受控条件下通过简单的烘箱干燥实现一致的试剂稳定，为小规模制造和资源有限的环境提供了冻干的实用替代方案。最后，研究结果为将几何模式扩展到多路检测布局（二孔、四孔、六孔或八孔配置）开辟了一条实用途径，其中精确的斑点定位和最小化信号重叠对于可靠的多分析物分析至关重要。这种方法为更可靠的纸质诊断提供了一种低成本、可制造的途径。

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引用次数: 0