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Self-powered infrared detector enabled by interfacial anchoring and thermal reinforcement 通过界面锚固和热加固实现自供电红外探测器
Pub Date : 2024-11-17 DOI: 10.1016/j.nwnano.2024.100061
Xiaolan Luo, Weixiong Li, Liu Yuan, Guangzhong Xie, Yuanjie Su
Pyroelectricity enables autonomous perception and remote detection in the field of infrared sensor, human machine interfacing and virtual reality. However, the low pyroelectric coefficient and inferior thermal conductivity hinders the energy conversion and signal transduction of pyroelectric sensors. Herein, we designed and prepared PZT-CNT/PVDF ternary composite (PTC) capable of infrared sensing and noncontact human machine interfacing (HMI). The incorporation of CNT not only facilitates the photo-thermal energy conversion and the heat transfer toward embedded PZT fillers, but also boost the all-trans conformation of fluoropolymer matrix and thus pyroelectric activity. The influence of CNT doping mass fractions on the pyroelectric noncontacted HMI and infrared detection properties was investigated. It is found that a doping content of 3 wt% gives rise to an optimal proximity sensitivity of 55.78 % and infrared detection optimum value of Fd 6.42 μPa−1/2, which is 13.97 % higher than that of the undoped version. This work provides insight into the interfacial coupling mechanism of pyroelectrics, and offers the new possibility for design of high-performance self-powered sensing devices.
热释电使红外传感器、人机界面和虚拟现实领域的自主感知和远程探测成为可能。然而,热释电系数低和热导率差阻碍了热释电传感器的能量转换和信号传输。在此,我们设计并制备了 PZT-CNT/PVDF 三元复合材料 (PTC),它能够进行红外传感和非接触式人机界面 (HMI)。CNT 的加入不仅促进了光热能量转换和向嵌入式 PZT 填料的热传递,还提高了氟聚合物基体的全反式构象,从而提高了热释电活性。研究了碳纳米管掺杂质量分数对热释电非接触式人机界面和红外探测性能的影响。结果发现,掺杂量为 3 wt% 时,最佳接近灵敏度为 55.78%,红外探测最佳值为 Fd 6.42 μPa-1/2,比未掺杂的版本高 13.97%。这项研究深入揭示了热释电的界面耦合机制,为设计高性能自供电传感设备提供了新的可能性。
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引用次数: 0
DNA origami-based nano-vaccines for cancer immunotherapy 基于 DNA 折纸的纳米疫苗用于癌症免疫疗法
Pub Date : 2024-11-16 DOI: 10.1016/j.nwnano.2024.100060
Tanvir Ahmed
Advancements in cancer immunotherapy have been notable; however, challenges remain regarding precision and the capacity to generate robust immune responses. This review explores the potential of DNA origami, an innovative method for structuring DNA into complex forms, as a platform for advanced cancer vaccines. DNA origami enables precise control over the molecular arrangement on its surface. Researchers can precisely modulate the immune response by conjugating tumor-specific antigens and adjuvants to DNA origami nanocarriers. This targeted approach demonstrates significant promise in overcoming the shortcomings of existing immunotherapies. This may enhance vaccine efficacy by facilitating the efficient delivery of antigens and adjuvants to immune cells. The precise control of adjuvant placement can minimize unnecessary immune stimulation and reduce unwanted side effects. The modular structure of DNA origami facilitates the development of personalized vaccines aimed at targeting specific mutations present in a patient's tumor. This advancement offers significant potential for bringing in a new era of precise cancer therapy. DNA origami nanocarriers demonstrate significant potential in enhancing the safety, efficacy, and precision of cancer immunotherapies.
癌症免疫疗法取得了显著进展,但在精确性和产生强大免疫反应的能力方面仍存在挑战。本综述探讨了 DNA 折纸作为先进癌症疫苗平台的潜力,DNA 折纸是一种将 DNA 结构化为复杂形式的创新方法。DNA 折纸能精确控制其表面的分子排列。研究人员可以通过将肿瘤特异性抗原和佐剂与 DNA 折纸纳米载体结合来精确调节免疫反应。这种有针对性的方法在克服现有免疫疗法的缺陷方面大有可为。这可以促进抗原和佐剂有效地传递到免疫细胞,从而提高疫苗的疗效。精确控制佐剂的放置可最大限度地减少不必要的免疫刺激,降低不必要的副作用。DNA 折纸的模块化结构有助于开发针对患者肿瘤中特定突变的个性化疫苗。这一进步为开创癌症精准治疗的新时代提供了巨大潜力。DNA 折纸纳米载体在提高癌症免疫疗法的安全性、有效性和精确性方面具有巨大潜力。
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引用次数: 0
Multifunctional scaffolds of β-tricalcium phosphate/bioactive glass coated with zinc oxide and copper oxide nanoparticles 涂有氧化锌和氧化铜纳米颗粒的β-磷酸三钙/生物活性玻璃多功能支架
Pub Date : 2024-11-10 DOI: 10.1016/j.nwnano.2024.100059
Rodrigo L.M.S. Oliveira , Lucas Barbosa , Thaís C. Pereira , Luísa R.M. Dona , Thiago G. Tabuti , Dayane B. Tada , Eduardo R. Triboni , Luciane D. de Oliveira , Eliandra S. Trichês
Incorporating nanoparticles into scaffolds with regenerative potential is a promissory strategy to provide them with antimicrobial activity. Bioceramics, such as β-tricalcium phosphate (β-TCP) and bioactive glasses (BGs), stand out among synthetic materials for bone regeneration. In this context, we report the incorporation of zinc oxide (ZnO) and copper oxide/copper nitrate (CuO/Cu2H3NO5) nanoparticles onto the surface of the β-TCP/BG scaffolds. This report addresses the physicochemical characterization of the scaffolds, their antimicrobial activity, and their response to MC3T3-E1 cells. Our findings show that the incorporation of both nanoparticles effectively inhibited S. aureus growth, including its biofilm formation. While the presence of the nanoparticles initially decreased MC3T3-E1 cell viability, cell proliferation improved with prolonged incubation. Overall, the β-TCP/BG_Zn and β-TCP/BG_Cu scaffolds showed an early antimicrobial response, aiding infection eradication, while also supporting cell proliferation over time.
在具有再生潜力的支架中加入纳米粒子,是使其具有抗菌活性的一种前景广阔的策略。β-磷酸三钙(β-TCP)和生物活性玻璃(BGs)等生物陶瓷在骨再生合成材料中脱颖而出。在此背景下,我们报告了在β-TCP/BG 支架表面加入氧化锌(ZnO)和氧化铜/硝酸铜(CuO/Cu2H3NO5)纳米颗粒的情况。本报告探讨了支架的理化特性、抗菌活性及其对 MC3T3-E1 细胞的反应。我们的研究结果表明,两种纳米粒子的加入都能有效抑制金黄色葡萄球菌的生长,包括其生物膜的形成。虽然纳米颗粒的存在最初会降低 MC3T3-E1 细胞的存活率,但随着培养时间的延长,细胞增殖情况有所改善。总之,β-TCP/BG_Zn 和 β-TCP/BG_Cu 支架显示出早期抗菌反应,有助于根除感染,同时随着时间的推移还能支持细胞增殖。
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引用次数: 0
Nanotechnology platforms for antigen and immunostimulant delivery in vaccine formulations 用于疫苗制剂中抗原和免疫刺激剂递送的纳米技术平台
Pub Date : 2024-11-08 DOI: 10.1016/j.nwnano.2024.100058
Patricio G. Márquez , Federico J. Wolman , Romina J. Glisoni
Vaccines represent a cornerstone in global health history, marking one of the most significant scientific achievements. Initially consisting of live or attenuated microorganisms, vaccines have evolved to include subunit vaccines, which offer greater specificity, safety, and production advantages. However, subunit vaccines require adjuvants due to the low immunogenicity of their antigens. These adjuvants include immunostimulatory molecules and particulate systems, which serve as carriers for both antigens and immunostimulants. The nanoscale dimensions of these particulate systems confer distinct advantages. This review comprehensively discusses FDA- and EMA-approved vaccines that incorporate adjuvants, emphasizing the growing use of nanoparticulate adjuvants in enhancing vaccine efficacy and safety. The unique physicochemical properties of nanoscopic systems, such as hydrodynamic size, shape, surface charge, hydrophobicity and degradation profiles are explored, that determine their effectiveness in vaccine formulations.
Furthermore, innovations in production scalability and alternative delivery routes, such as oral or transdermal vaccines, offer promising solutions to global vaccine accessibility challenges, particularly in resource-limited settings. The ongoing integration of nanotechnology platforms thus continues to expand the potential of vaccines, ensuring safer, more effective, and more accessible solutions for global immunization efforts.
疫苗是全球卫生史上的基石,标志着最重要的科学成就之一。疫苗最初由活的或减毒的微生物组成,现在已发展到包括亚单位疫苗在内的疫苗,亚单位疫苗具有更高的特异性、安全性和生产优势。然而,由于亚单位疫苗抗原的免疫原性较低,因此需要使用佐剂。这些佐剂包括免疫刺激分子和微粒系统,可作为抗原和免疫刺激剂的载体。这些微粒系统的纳米级尺寸具有独特的优势。本综述全面讨论了 FDA 和 EMA 批准的含有佐剂的疫苗,强调了纳米颗粒佐剂在提高疫苗功效和安全性方面日益广泛的应用。此外,生产可扩展性和替代给药途径(如口服或透皮疫苗)方面的创新为全球疫苗可及性挑战提供了前景广阔的解决方案,尤其是在资源有限的环境中。因此,纳米技术平台的不断整合将继续扩大疫苗的潜力,确保为全球免疫工作提供更安全、更有效、更易获得的解决方案。
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引用次数: 0
Advances in cardiac sounds monitoring enabled by triboelectric sensors 三电传感器在心音监测方面取得的进展
Pub Date : 2024-11-03 DOI: 10.1016/j.nwnano.2024.100057
Xindan Hui , Hengyu Guo
Cardiac sounds sensor as a noninvasive instrument plays a pivotal role in the early diagnosis of various heart disease. In recent years, triboelectric nanogenerators (TENGs) have been employed widely for sensing different physiological information benefiting from abundant materials choices, simplicity of construction and low cost. More importantly, the fast saturated constitutive characteristic of the contact-separation mode (C-S) TENG demonstrates ultrahigh sensitivity in the detection of micromechanical quantities than traditional piezoelectric sensing mechanism. This article presents an overview of the C-S TENG enabled self-powered cardiac sounds monitoring, focusing on the working principle, performance comparison between C-S TENG and piezoelectric generator (PEG), and related applications. The challenges and future research directions of cardiac sounds sensor and C-S TENG toward micro-displacement region have also been proposed.
心音传感器作为一种无创仪器,在各种心脏病的早期诊断中发挥着举足轻重的作用。近年来,三电纳米发生器(TENGs)以其材料选择丰富、构造简单、成本低廉等优点被广泛应用于传感不同的生理信息。更重要的是,与传统的压电传感机制相比,接触分离模式(C-S)三电纳米发生器的快速饱和构成特性在检测微机械量方面具有超高灵敏度。本文概述了 C-S TENG 的工作原理、C-S TENG 与压电发生器 (PEG) 的性能比较以及相关应用,并介绍了实现自供电心音监测的 C-S TENG。此外,还提出了心音传感器和 C-S TENG 面向微位移区域的挑战和未来研究方向。
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引用次数: 0
A novel non-catalytic plasmonic immunoabsorbant assay amplification mechanism 新型非催化质子免疫吸附测定放大机制
Pub Date : 2024-10-15 DOI: 10.1016/j.nwnano.2024.100056
Aditya Saran , Shuai Hou , Yinglu Ji
The amplification of signals is dependent upon enzyme/ catalyst. Enzyme activity, specificity, pH condition, enzyme linkers, stability, storage and efficiency are some very important factors that can eventually affect the detection results. We aimed to amplify signals without the assistance of enzyme/ catalyst so that the strategy can be used in the wide range of signal detection including immune-assay. Silver nanocrystals (Ag NCs) grown from self-nucleation are used as chromogens due to their strong plasmon band at ∼ 400 nm. During 140 s of reaction time in presence of 6.10 mM CTAB and 0.61 mM of AgNO3, the 0.57 mM of Ascorbic acid allows Ag over growth on antibody-tagged gold nanospheres (10±0.5 nm) that competes silver atoms from the self-nucleation growth and thus affects the growth kinetics of the latter. By utilizing the opened kinetic window, sensitive detection has been achieved from 6.67 × 10–14 M (1 pg) to 3.33 × 10–9 M (50 ng) using human IgG as a model protein. The non-catalytic plasmonic immunoabsorbant assay we developed herein adds a new possibility of plasmonic NPs for sensitive detection. The detection slope and resolution is higher and better than those via signal amplification through the assistance of enzymes/ catalysts. This work supports the concept that nanoparticles mediated reactions are sensitive enough that they have the potential to go independently without enzymes/ catalyst assistance.
信号的放大取决于酶/催化剂。酶的活性、特异性、pH 值条件、酶连接物、稳定性、储存和效率等都是影响检测结果的重要因素。我们的目标是在没有酶/催化剂辅助的情况下放大信号,从而使该策略可用于包括免疫测定在内的各种信号检测。由于银纳米晶体(Ag NCs)在 ∼ 400 nm 处具有很强的等离子体波段,因此我们采用自核生长的银纳米晶体(Ag NCs)作为发色剂。在 6.10 mM CTAB 和 0.61 mM AgNO3 存在下的 140 秒反应时间内,0.57 mM 抗坏血酸允许银在抗体标记的金纳米球(10±0.5 nm)上过度生长,竞争自核生长的银原子,从而影响后者的生长动力学。利用打开的动力学窗口,以人类 IgG 为模型蛋白,实现了从 6.67 × 10-14 M(1 pg)到 3.33 × 10-9 M(50 ng)的灵敏检测。我们在此开发的非催化质子免疫吸附测定为质子 NPs 的灵敏检测增添了新的可能性。其检测斜率和分辨率比通过酶/催化剂辅助信号放大的方法更高、更好。这项工作支持了这样一种概念,即纳米粒子介导的反应灵敏度足够高,有可能在没有酶/催化剂辅助的情况下独立进行。
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引用次数: 0
Peeling-induced interfacial roughness and charging for enhanced triboelectric power generation 剥离诱导的界面粗糙度和充电,用于增强三电发电功能
Pub Date : 2024-10-05 DOI: 10.1016/j.nwnano.2024.100055
Da Woon Jin , Hyun Soo Ahn , Dheeraj Kumar , Joo Hyeong Lee , Min Su Kim , Yushin Eom , Ji Ho Youk , Huidrom Hemojit Singh , Jong Hun Kim , Jong Hoon Jung
To date, there have been a lot of efforts to enhance the conversion efficiency of triboelectric nanogenerators (TENGs) via physical and chemical modifications of the polymer surface. Herein, we report that a facile peeling of polymer from a substrate can enhance the triboelectric power output. The peeling of spin-coated polydimethylsiloxane (PDMS) from glass and polytetrafluoroethylene (PTFE) substrates has revealed a considerable increase in interfacial roughness and lateral friction. Surface-sensitive X-ray photoemission spectroscopy and non-contact current measurements have also revealed the transfer of counter-material and interfacial charging. The surface roughness of peeled PDMS is significant for the PTFE substrate, while the surface charge is significant for the glass substrate. The triboelectric output power density for peeled PDMS from the substrate is similar, 10.3 µW/cm2, but significantly larger than that for as-grown PDMS (2.2 µW/cm2). The peeling strength of PDMS significantly increases for glass compared to PTFE after the oxygen plasma treatment of substrates. The triboelectric charge of peeled PDMS from a plasma-treated glass substrate is almost 1.3 times larger than that from a PTFE substrate. This work implies that peeling polymer from a rough substrate with a large adhesion force would be a facile and effective way to increase the triboelectric power output, without any delicate surface treatments.
迄今为止,人们一直在努力通过对聚合物表面进行物理和化学改性来提高三电纳米发电机(TENGs)的转换效率。在此,我们报告了从基底上轻松剥离聚合物可以提高三电功率输出。从玻璃和聚四氟乙烯(PTFE)基材上剥离自旋涂层聚二甲基硅氧烷(PDMS)时发现,界面粗糙度和横向摩擦力显著增加。表面敏感 X 射线光发射光谱和非接触电流测量也揭示了反材料和界面充电的转移。对于聚四氟乙烯基底,剥离的 PDMS 表面粗糙度显著,而对于玻璃基底,表面电荷显著。从基底上剥离的 PDMS 的三电输出功率密度相似,为 10.3 µW/cm2,但明显大于生长的 PDMS(2.2 µW/cm2)。在对基底进行氧等离子处理后,玻璃的 PDMS 剥离强度明显高于聚四氟乙烯。从经过等离子处理的玻璃基底剥离的 PDMS 的三电荷几乎是 PTFE 基底的 1.3 倍。这项研究表明,从具有较大附着力的粗糙基底上剥离聚合物是提高三电功率输出的一种简便有效的方法,而无需进行任何精细的表面处理。
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引用次数: 0
Review on nanocellulose production from agricultural residue through response surface methodology and its applications 通过响应面方法利用农业残留物生产纳米纤维素及其应用综述
Pub Date : 2024-10-02 DOI: 10.1016/j.nwnano.2024.100054
Marjun C. Alvarado , Ma. Cristine Concepcion D. Ignacio , Ma. Camille G. Acabal , Anniver Ryan P. Lapuz , Kevin F. Yaptenco
Nanocellulose (NC) shows great potential across industries like food, pharmaceuticals, cosmetics, textiles, electronics, and construction. It can be sustainably extracted from agricultural residues using methods such as mechanical processes, acid hydrolysis, and bacterial biosynthesis. This review emphasizes the use of Response Surface Methodology (RSM) in optimizing NC extraction by examining variables like acid concentration, reaction time, and temperature. While RSM is effective, its assumptions of linear and quadratic relationships limit its accuracy in complex systems. Advanced techniques like artificial neural networks (ANN) offer a better alternative, capturing nonlinear relationships more effectively. However, ANN's application in NC extraction is underexplored, calling for future research to improve model precision. Expanding optimization to include response variables like thermal stability and surface charge is also essential for enhancing NC's industrial applications.
纳米纤维素(NC)在食品、制药、化妆品、纺织、电子和建筑等行业显示出巨大的潜力。它可以通过机械加工、酸水解和细菌生物合成等方法从农业残留物中可持续地提取出来。本综述强调了响应面法(RSM)在优化数控萃取中的应用,具体方法是研究酸浓度、反应时间和温度等变量。虽然 RSM 很有效,但其线性和二次关系假设限制了其在复杂系统中的准确性。人工神经网络(ANN)等先进技术提供了更好的选择,能更有效地捕捉非线性关系。然而,人工神经网络在数控提取中的应用还未得到充分开发,这就要求我们在未来开展研究,以提高模型的精确度。扩大优化范围,将热稳定性和表面电荷等响应变量纳入其中,对于提高 NC 的工业应用也至关重要。
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引用次数: 0
The synergy of artificial intelligence and nanotechnology towards advancing innovation and sustainability - A mini-review 人工智能与纳米技术在推动创新和可持续发展方面的协同作用 - 综述
Pub Date : 2024-09-29 DOI: 10.1016/j.nwnano.2024.100052
David B. Olawade , Abimbola O. Ige , Abimbola G. Olaremu , James O. Ijiwade , Adedapo O. Adeola
The convergence of Artificial Intelligence (AI) and nanotechnology is a transformative frontier, holding vast potential for scientific and technological advancements. This review explores the integration of AI and nanotechnology, aiming to uncover current trends, challenges, and future directions across various domains. A scientometric approach was employed, gathering and analyzing existing literature and research in the fields of AI and nanotechnology. Through a systematic examination of recent studies and developments, we identified key trends, challenges, and potential pathways for future research and applications. Findings from this review highlight the significant impact of AI-driven nanotechnology in materials discovery and design, healthcare, environmental monitoring, energy conversion, and quantum computing. These areas have witnessed remarkable advancements, such as the development of novel nanomaterials, precise drug delivery systems, advanced nanosensors, and efficient energy storage solutions. However, challenges persist, including insufficient interdisciplinary collaboration, data quality, ethical concerns, and regulatory frameworks. While challenges require careful consideration and mitigation, the potential for innovation and progress in diverse domains is undeniable. This review underscores the importance of responsible AI use and ongoing research to unlock the full potential of this convergence, ultimately shaping the future of science and technology.
人工智能(AI)与纳米技术的融合是一个变革性的前沿领域,蕴含着科技进步的巨大潜力。本综述探讨了人工智能与纳米技术的融合,旨在揭示各个领域的当前趋势、挑战和未来方向。本综述采用科学计量学方法,收集并分析了人工智能和纳米技术领域的现有文献和研究。通过对最近的研究和发展进行系统检查,我们确定了未来研究和应用的主要趋势、挑战和潜在途径。本综述的研究结果凸显了人工智能驱动的纳米技术在材料发现和设计、医疗保健、环境监测、能源转换和量子计算方面的重大影响。这些领域已经取得了令人瞩目的进步,例如新型纳米材料、精确给药系统、先进纳米传感器和高效能源存储解决方案的开发。然而,挑战依然存在,包括跨学科合作不足、数据质量、伦理问题和监管框架。尽管挑战需要认真考虑和缓解,但不可否认的是,不同领域都存在创新和进步的潜力。本综述强调了负责任地使用人工智能和持续开展研究的重要性,以充分释放这种融合的潜力,最终塑造科学与技术的未来。
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引用次数: 0
Self-powered highly stretchable ferroelectret nanogenerator towards intelligent sports 面向智能运动的自供电高伸展性铁电体纳米发电机
Pub Date : 2024-09-28 DOI: 10.1016/j.nwnano.2024.100053
Yiqin Wang , Xianfa Cai , Yufeng Guo , Zhi Chen , Yunqi Cao , Wangdi Du , Tian Xia , Nelson Sepulveda , Wei Li
Ferroelectret nanogenerators (FENGs), recognized for their porous structures that facilitate charge retention, thereby creating giant electric dipoles and exhibiting remarkable piezoelectric properties, are utilized in the development of various flexible transducers. However, despite their flexibility, most developed ferroelectret nanogenerators lack adequate stretchability and satisfactory transverse piezoelectric properties, significantly inhibiting their widespread deployment in wearable or skin-mounted electronics. Here, we introduce a highly stretchable ferroelectret nanogenerator (HS-FENG) built from laser-induced graphene (LIG), Ecoflex and anhydrous ethanol, demonstrating exceptional flexibility and stretchability, along with longitudinal and transverse piezoelectric effects. The stretchability of HS-FENG can reach a record of 468 %, while the quasi-static piezoelectric coefficients d33 and d31 are approximately 120 pC/N and 70 pC/N, respectively. To our knowledge, this is the first demonstration of the developed FENG with remarkably high stretchability. Furthermore, leveraging the performance of the created HS-FENG, we construct a skin-mounted intelligent kinesiology tape capable of effectively monitoring motion signals from human muscles and joints, thereby offering a deeper understanding of movement for users across different levels of physical activity, from professional athletes to individuals undergoing rehabilitation. The development of intelligent kinesiology tape exemplifies the potential of HS-FENG technology in enhancing professional athletic training and personalized healthcare. It contributes to the advancement of inconspicuous skin-mounted biomechanical feedback systems and human-machine interfaces, marking progress in the field.
铁蕊体纳米发电机(FENGs)因其多孔结构可促进电荷保持,从而产生巨大的电偶极子并表现出显著的压电特性而被广泛应用于各种柔性传感器的开发。然而,尽管具有柔性,但大多数已开发的铁电体纳米发电机都缺乏足够的可拉伸性和令人满意的横向压电特性,这极大地阻碍了它们在可穿戴或皮肤安装电子设备中的广泛应用。在这里,我们介绍了一种由激光诱导石墨烯(LIG)、Ecoflex 和无水乙醇制成的高拉伸性铁电体纳米发电机(HS-FENG),它具有优异的柔韧性和拉伸性,以及纵向和横向压电效应。HS-FENG 的拉伸性达到了创纪录的 468%,准静态压电系数 d33 和 d31 分别约为 120 pC/N 和 70 pC/N。据我们所知,这是首次展示所开发的 FENG 具有极高的拉伸性。此外,利用所创造的 HS-FENG 的性能,我们构建了一种安装在皮肤上的智能运动胶带,它能够有效监测来自人体肌肉和关节的运动信号,从而为不同运动水平的用户(从专业运动员到正在接受康复治疗的个人)提供对运动的更深入了解。智能运动胶带的开发体现了 HS-FENG 技术在提高专业运动训练和个性化医疗保健方面的潜力。它为不显眼的皮肤安装生物力学反馈系统和人机界面的发展做出了贡献,标志着该领域的进步。
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