Pub Date : 2025-12-10DOI: 10.1016/j.nwnano.2025.100172
Ismail Benaicha , Imane Laazizi , Youness Ait Alla , Jaouad Mhalla , Hafsa Diyagh , Khalid Nouneh , Smail Amraoui , Atika Fahmi , Marouan Karam , Ahmed Qachaou , Mounir Fahoume
This study presents a first-principles analysis of the structural, mechanical, and optoelectronic properties of the lead-free perovskite series RbBeBrI (, 1, 2, 3) using density functional theory. We investigate the trade-offs between property tuning and stability. While all compositions satisfy the Goldschmidt tolerance factor, formation energy calculations reveal that the mixed-halide phases () are thermodynamically unstable relative to the pure-halide end members (RbBeBr and RbBeI). Mechanical analysis confirms the stability of RbBeBr, RbBeBrI, and RbBeI, but crucially identifies RbBeBrI as elastically unstable, evidenced by a negative elastic eigenvalue of 1.7171 GPa. Progressive iodine substitution induces systematic lattice softening, reducing the Hill-averaged Young’s modulus from 26.6 GPa () to 19.7 GPa (). Optoelectronically, iodine substitution effectively tunes the bandgap from 2.106 eV (indirect) for RbBeBr to 0.495 eV (direct) for RbBeI. This is driven by the I-5 orbitals elevating the valence band maximum. Consequently, the optical absorption edge redshifts, enhancing visible-light harvesting. Our findings demonstrate that RbBeBrI offers significant optoelectronic tunability but highlights critical thermodynamic and elastic instabilities in the mixed-halide compositions, suggesting non-equilibrium synthesis routes are necessary for their practical realization.
{"title":"Design and analysis of RbBeBr3−xIx (x=0–3) lead-free perovskites: Tunable mechanical and optoelectronic properties via iodine substitution","authors":"Ismail Benaicha , Imane Laazizi , Youness Ait Alla , Jaouad Mhalla , Hafsa Diyagh , Khalid Nouneh , Smail Amraoui , Atika Fahmi , Marouan Karam , Ahmed Qachaou , Mounir Fahoume","doi":"10.1016/j.nwnano.2025.100172","DOIUrl":"10.1016/j.nwnano.2025.100172","url":null,"abstract":"<div><div>This study presents a first-principles analysis of the structural, mechanical, and optoelectronic properties of the lead-free perovskite series RbBeBr<span><math><msub><mrow></mrow><mrow><mn>3</mn><mo>−</mo><mi>x</mi></mrow></msub></math></span>I<span><math><msub><mrow></mrow><mrow><mi>x</mi></mrow></msub></math></span> (<span><math><mrow><mi>x</mi><mo>=</mo><mn>0</mn></mrow></math></span>, 1, 2, 3) using density functional theory. We investigate the trade-offs between property tuning and stability. While all compositions satisfy the Goldschmidt tolerance factor, formation energy calculations reveal that the mixed-halide phases (<span><math><mrow><mi>x</mi><mo>=</mo><mn>1</mn><mo>,</mo><mn>2</mn></mrow></math></span>) are thermodynamically unstable relative to the pure-halide end members (RbBeBr<span><math><msub><mrow></mrow><mrow><mn>3</mn></mrow></msub></math></span> and RbBeI<span><math><msub><mrow></mrow><mrow><mn>3</mn></mrow></msub></math></span>). Mechanical analysis confirms the stability of RbBeBr<span><math><msub><mrow></mrow><mrow><mn>3</mn></mrow></msub></math></span>, RbBeBr<span><math><msub><mrow></mrow><mrow><mn>1</mn></mrow></msub></math></span>I<span><math><msub><mrow></mrow><mrow><mn>2</mn></mrow></msub></math></span>, and RbBeI<span><math><msub><mrow></mrow><mrow><mn>3</mn></mrow></msub></math></span>, but crucially identifies RbBeBr<span><math><msub><mrow></mrow><mrow><mn>2</mn></mrow></msub></math></span>I<span><math><msub><mrow></mrow><mrow><mn>1</mn></mrow></msub></math></span> as elastically unstable, evidenced by a negative elastic eigenvalue of <span><math><mo>−</mo></math></span>1.7171 GPa. Progressive iodine substitution induces systematic lattice softening, reducing the Hill-averaged Young’s modulus from 26.6 GPa (<span><math><mrow><mi>x</mi><mo>=</mo><mn>0</mn></mrow></math></span>) to 19.7 GPa (<span><math><mrow><mi>x</mi><mo>=</mo><mn>3</mn></mrow></math></span>). Optoelectronically, iodine substitution effectively tunes the bandgap from 2.106 eV (indirect) for RbBeBr<span><math><msub><mrow></mrow><mrow><mn>3</mn></mrow></msub></math></span> to 0.495 eV (direct) for RbBeI<span><math><msub><mrow></mrow><mrow><mn>3</mn></mrow></msub></math></span>. This is driven by the I-5<span><math><mi>p</mi></math></span> orbitals elevating the valence band maximum. Consequently, the optical absorption edge redshifts, enhancing visible-light harvesting. Our findings demonstrate that RbBeBr<span><math><msub><mrow></mrow><mrow><mn>3</mn><mo>−</mo><mi>x</mi></mrow></msub></math></span>I<span><math><msub><mrow></mrow><mrow><mi>x</mi></mrow></msub></math></span> offers significant optoelectronic tunability but highlights critical thermodynamic and elastic instabilities in the mixed-halide compositions, suggesting non-equilibrium synthesis routes are necessary for their practical realization.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"13 ","pages":"Article 100172"},"PeriodicalIF":0.0,"publicationDate":"2025-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145738621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-10DOI: 10.1016/j.nwnano.2025.100173
Sinan S. Hamdi , Zinah N. Alabdali , Farah F. Alkalid
As a rapid development in the field of nanocomposite materials, sol-gel is considered one of the most accurate ways for preparation nanocomposite. Nanocomposite is usually characterized by scanning electron microscopy (SEM) for measuring the nano particle size. The major drawbacks of using scanning electron microscopy are the focus on small areas of the image. It takes a long time to measure a small area and depends on human skill, which involves manually drawing a line over each particle to calculate the average. Therefore, it is reliable, easy, fast, and simple way to computing program. A computing program refers to a set of instructions designed to achieve specific objectives, commonly known as algorithms. In this research, sol-gel was used to prepare NiO-Al2O3 nanocomposite, then scanning electron microscope (SEM) was used to estimate the particle size of the SEM image. Afterward, an algorithm was proposed for calculating the particle size of NiO-Al2O3 nanocomposite by applying computer vision. Eight of the preprocessing approaches are used for image enhancement: Histogram Equalization, CLAHE, Gaussian Blurred, Median Blurred, Bilateral Filter, Unsharp filter, Sobel and Wavelet. The results of particle size measured manually from the SEM image was 42 nm while the computer vision using CLAHE was 38 nm with particle detection of 86 % and Median Blurred is 42 nm with particle detection is 71 %. Therefore, the CLAHE algorithm shows the most accurate because it detects more particles than the other algorithms.
{"title":"Study analysis of consuming computer vision approaches for calculating the particle size of NiO- Al2O3 nanocomposite","authors":"Sinan S. Hamdi , Zinah N. Alabdali , Farah F. Alkalid","doi":"10.1016/j.nwnano.2025.100173","DOIUrl":"10.1016/j.nwnano.2025.100173","url":null,"abstract":"<div><div>As a rapid development in the field of nanocomposite materials, sol-gel is considered one of the most accurate ways for preparation nanocomposite. Nanocomposite is usually characterized by scanning electron microscopy (SEM) for measuring the nano particle size. The major drawbacks of using scanning electron microscopy are the focus on small areas of the image. It takes a long time to measure a small area and depends on human skill, which involves manually drawing a line over each particle to calculate the average. Therefore, it is reliable, easy, fast, and simple way to computing program. A computing program refers to a set of instructions designed to achieve specific objectives, commonly known as algorithms. In this research, sol-gel was used to prepare NiO-Al<sub>2</sub>O<sub>3</sub> nanocomposite, then scanning electron microscope (SEM) was used to estimate the particle size of the SEM image. Afterward, an algorithm was proposed for calculating the particle size of NiO-Al<sub>2</sub>O<sub>3</sub> nanocomposite by applying computer vision. Eight of the preprocessing approaches are used for image enhancement: Histogram Equalization, CLAHE, Gaussian Blurred, Median Blurred, Bilateral Filter, Unsharp filter, Sobel and Wavelet. The results of particle size measured manually from the SEM image was 42 nm while the computer vision using CLAHE was 38 nm with particle detection of 86 % and Median Blurred is 42 nm with particle detection is 71 %. Therefore, the CLAHE algorithm shows the most accurate because it detects more particles than the other algorithms.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"13 ","pages":"Article 100173"},"PeriodicalIF":0.0,"publicationDate":"2025-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145739269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-09DOI: 10.1016/j.nwnano.2025.100174
Mansi Agarwal , Ramakrishnan Ganesan , Jayati Ray Dutta
The rapid escalation of antimicrobial resistance (AMR) has rendered conventional antibiotics increasingly ineffective, particularly in chronic wound management and implant-associated infections where biofilm formation impedes drug penetration and fosters multidrug-resistant pathogens. Functional nanomaterials—encompassing metallic and metal-oxide nanoparticles, carbon-based nanostructures, polymeric and hybrid nanocomposites, and stimuli-responsive systems—offer transformative solutions by enabling localized, sustained, and multimodal antimicrobial action. These nanoscale platforms disrupt bacterial membranes, generate reactive oxygen species (ROS), release therapeutic ions or payloads in a controlled manner, and integrate regenerative cues to accelerate tissue repair. In wound dressings, nanomaterial integration enhances antimicrobial efficacy, angiogenesis, and moisture balance, while advanced implant coatings deliver biofilm-resistant, osteoinductive, and infection-responsive surfaces without systemic toxicity. This review synthesizes advances from 2010 to 2025, emphasizing biofilm-disruption mechanisms, smart drug-release strategies, and the clinical translation of nanomaterial-enabled therapies. It critically evaluates biosafety, regulatory, and scalability challenges, while outlining future directions including AI-guided material design, personalized nanomedicine, and sustainable synthesis approaches. By uniting antimicrobial potency with regenerative functionality, functional nanomaterials represent a paradigm shift in combating AMR at the interface of infection control and tissue engineering.
{"title":"Functional nanomaterials in combating antimicrobial resistance: Innovations in wound dressings and biomedical implants","authors":"Mansi Agarwal , Ramakrishnan Ganesan , Jayati Ray Dutta","doi":"10.1016/j.nwnano.2025.100174","DOIUrl":"10.1016/j.nwnano.2025.100174","url":null,"abstract":"<div><div>The rapid escalation of antimicrobial resistance (AMR) has rendered conventional antibiotics increasingly ineffective, particularly in chronic wound management and implant-associated infections where biofilm formation impedes drug penetration and fosters multidrug-resistant pathogens. Functional nanomaterials—encompassing metallic and metal-oxide nanoparticles, carbon-based nanostructures, polymeric and hybrid nanocomposites, and stimuli-responsive systems—offer transformative solutions by enabling localized, sustained, and multimodal antimicrobial action. These nanoscale platforms disrupt bacterial membranes, generate reactive oxygen species (ROS), release therapeutic ions or payloads in a controlled manner, and integrate regenerative cues to accelerate tissue repair. In wound dressings, nanomaterial integration enhances antimicrobial efficacy, angiogenesis, and moisture balance, while advanced implant coatings deliver biofilm-resistant, osteoinductive, and infection-responsive surfaces without systemic toxicity. This review synthesizes advances from 2010 to 2025, emphasizing biofilm-disruption mechanisms, smart drug-release strategies, and the clinical translation of nanomaterial-enabled therapies. It critically evaluates biosafety, regulatory, and scalability challenges, while outlining future directions including AI-guided material design, personalized nanomedicine, and sustainable synthesis approaches. By uniting antimicrobial potency with regenerative functionality, functional nanomaterials represent a paradigm shift in combating AMR at the interface of infection control and tissue engineering.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"13 ","pages":"Article 100174"},"PeriodicalIF":0.0,"publicationDate":"2025-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145791776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-08DOI: 10.1016/j.nwnano.2025.100170
Shrihari B. Patil , Priyanka P. Patil , Sourav D. Gore , Shashidhar C. Patil , Rahul Koli
Wound healing is a complex, multistage physiological process involving hemostasis, inflammation, proliferation, and remodeling. Despite progress in conventional therapies, chronic and infected wounds remain major global health burdens, necessitating advanced biomaterial-based interventions. In recent years, nanoparticle-based delivery systems have emerged as transformative platforms for accelerating tissue repair, preventing infection, and modulating inflammatory pathways. This review comprehensively explores the integration of metal-based nanoparticles—including silver (Ag), gold (Au), copper (Cu), titanium (Ti), zinc (Zn), manganese (Mn), and cerium (Ce)—and biopolymeric or lipid-based nanostructures, such as nanoemulsions, hydrogels, solid lipid nanoparticles, and polymeric composites, in modern wound-healing strategies. These nanosystems exhibit superior bioavailability, controlled release, and targeted delivery of therapeutic phytoconstituents and biomolecules. In parallel, the growing body of herbal formulation patents demonstrates how traditional phytotherapy and modern nanotechnology are converging to create multifunctional, eco-sustainable wound-healing products with enhanced clinical potential. Key innovations include synergistic antimicrobial–anti-inflammatory activity, improved collagen synthesis, angiogenesis, and re-epithelialization. Together, these advancements mark a paradigm shift toward nanostructured herbal therapeutics that are biocompatible, stable, and scalable for translational and industrial development. This review provides a critical synthesis of current trends, mechanistic insights, and emerging directions, underscoring how nanoparticle-enabled herbal formulations are redefining the future of regenerative wound care.
{"title":"Nanoparticle-enabled herbal therapeutics for wound healing: bridging traditional medicine and modern nanotechnology","authors":"Shrihari B. Patil , Priyanka P. Patil , Sourav D. Gore , Shashidhar C. Patil , Rahul Koli","doi":"10.1016/j.nwnano.2025.100170","DOIUrl":"10.1016/j.nwnano.2025.100170","url":null,"abstract":"<div><div>Wound healing is a complex, multistage physiological process involving hemostasis, inflammation, proliferation, and remodeling. Despite progress in conventional therapies, chronic and infected wounds remain major global health burdens, necessitating advanced biomaterial-based interventions. In recent years, nanoparticle-based delivery systems have emerged as transformative platforms for accelerating tissue repair, preventing infection, and modulating inflammatory pathways. This review comprehensively explores the integration of metal-based nanoparticles—including silver (Ag), gold (Au), copper (Cu), titanium (Ti), zinc (Zn), manganese (Mn), and cerium (Ce)—and biopolymeric or lipid-based nanostructures, such as nanoemulsions, hydrogels, solid lipid nanoparticles, and polymeric composites, in modern wound-healing strategies. These nanosystems exhibit superior bioavailability, controlled release, and targeted delivery of therapeutic phytoconstituents and biomolecules. In parallel, the growing body of herbal formulation patents demonstrates how traditional phytotherapy and modern nanotechnology are converging to create multifunctional, eco-sustainable wound-healing products with enhanced clinical potential. Key innovations include synergistic antimicrobial–anti-inflammatory activity, improved collagen synthesis, angiogenesis, and re-epithelialization. Together, these advancements mark a paradigm shift toward nanostructured herbal therapeutics that are biocompatible, stable, and scalable for translational and industrial development. This review provides a critical synthesis of current trends, mechanistic insights, and emerging directions, underscoring how nanoparticle-enabled herbal formulations are redefining the future of regenerative wound care.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"13 ","pages":"Article 100170"},"PeriodicalIF":0.0,"publicationDate":"2025-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145926625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-08DOI: 10.1016/j.nwnano.2025.100171
M.R. Alipoor , M. Eshghi , O. Akhavan
Effective radiation shielding is critical for medical and nuclear safety, but conventional lead-based materials are toxic and heavy. However, a high-performance, non-toxic alternative with optimized composition for mixed-field radiation remains an unmet need. Here establish a new class of lightweight, lead-free shields using dysprosium-doped Mn–Cu ferrite nanocomposites. The selected nanocomposites with varying Dy concentrations (0 to15 mole) and evaluated their gamma-ray (0.015 to 1 MeV) and fast neutron shielding performance. Key parameters, including mass attenuation coefficient, half-value layer and fast neutron removal cross-section (ΣR), were simulated using the Geant4 toolkit. Shielding efficacy increased systematically with Dy content. The 15% Dy-doped sample (MCDFO15) demonstrated unprecedented performance, requiring up to 25% less thickness than the undoped composite at 200 keV for equivalent gamma attenuation. MCDFO15 exhibited a superior fast neutron removal cross-section (ΣR ≈ 0.062 cm⁻¹ vs. 0.054 cm⁻¹ for MCFO) and a higher neutron absorption ratio. This enhancement is directly attributable to the increased effective atomic number and electron density from Dy doping. Dy doping transforms the intrinsic shielding properties of ferrite nanocomposites, establishing a highly effective strategy for radiation protection. This work paves the way for the development of tunable, non-toxic shields for advanced diagnostic and nuclear applications.
{"title":"Radiation shielding for nuclear medicine using advanced dy-doped nanocomposites","authors":"M.R. Alipoor , M. Eshghi , O. Akhavan","doi":"10.1016/j.nwnano.2025.100171","DOIUrl":"10.1016/j.nwnano.2025.100171","url":null,"abstract":"<div><div>Effective radiation shielding is critical for medical and nuclear safety, but conventional lead-based materials are toxic and heavy. However, a high-performance, non-toxic alternative with optimized composition for mixed-field radiation remains an unmet need. Here establish a new class of lightweight, lead-free shields using dysprosium-doped Mn–Cu ferrite nanocomposites. The selected nanocomposites with varying Dy concentrations (0 to15 mole) and evaluated their gamma-ray (0.015 to 1 MeV) and fast neutron shielding performance. Key parameters, including mass attenuation coefficient, half-value layer and fast neutron removal cross-section (Σ<sub>R</sub>), were simulated using the Geant4 toolkit. Shielding efficacy increased systematically with Dy content. The 15% Dy-doped sample (MCDFO15) demonstrated unprecedented performance, requiring up to 25% less thickness than the undoped composite at 200 keV for equivalent gamma attenuation. MCDFO15 exhibited a superior fast neutron removal cross-section (Σ<sub>R</sub> ≈ 0.062 cm⁻¹ vs. 0.054 cm⁻¹ for MCFO) and a higher neutron absorption ratio. This enhancement is directly attributable to the increased effective atomic number and electron density from Dy doping. Dy doping transforms the intrinsic shielding properties of ferrite nanocomposites, establishing a highly effective strategy for radiation protection. This work paves the way for the development of tunable, non-toxic shields for advanced diagnostic and nuclear applications.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"13 ","pages":"Article 100171"},"PeriodicalIF":0.0,"publicationDate":"2025-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145926626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01DOI: 10.1016/j.nwnano.2025.100167
A. Arıvazhagan , Jahangir Ahmed , Karthikeyan Ramalingam
Multidrug-resistant (MDR) Klebsiella pneumoniae (Kp) presents a significant clinical threat due to its resistance to multiple antibiotics and its enhanced virulence. Key outer membrane porins, OmpK35 and OmpK36, contribute to this resistance by limiting antibiotic influx and supporting bacterial survival. This study aimed to identify and evaluate phytochemicals targeting these porins using an integrated in silico -in vitro approach.
Over 100 phytocompounds were screened via molecular docking, revealing N-curcumin and myricetin as top candidates with binding affinities of -7.33 kcal/mol (OmpK35) and -7.58 kcal/mol (OmpK36), respectively. ADMET profiling supported their drug-likeness and safety. These compounds were further evaluated against reference and clinical Kp strains.
Minimum bactericidal concentration (MBC) assays showed that both N-curcumin and myricetin achieved effective killing at 7.5 mg/mL. Biofilm inhibition rates ranged from 40-48%, comparable to standard gentamicin. Crystal violet staining and microscopy confirmed significant biofilm disruption. Additionally, oxygen consumption rate (OCR) assays revealed substantial reductions in metabolic activity. Myricetin led to OCR decreases of 0.40-, 0.52-, and 0.35-fold against MTCC-432, ATCC-35657, and CL-1 strains, respectively.
Collectively, these findings highlight the dual antibacterial and antivirulence potential of N-curcumin and myricetin. Their ability to disrupt membrane protein function, inhibit biofilm formation, and impair bacterial respiration offers strong promise for their development as alternative therapeutics against MDR K. pneumoniae. This study supports the ongoing search for plant-derived compounds in the fight against resistant Gram-negative pathogens.
{"title":"In-silico and in-vitro evaluation of phytochemicals targeting outer membrane proteins OmpK35 and OmpK36 of MDR Klebsiella pneumonia","authors":"A. Arıvazhagan , Jahangir Ahmed , Karthikeyan Ramalingam","doi":"10.1016/j.nwnano.2025.100167","DOIUrl":"10.1016/j.nwnano.2025.100167","url":null,"abstract":"<div><div>Multidrug-resistant (MDR) Klebsiella pneumoniae (Kp) presents a significant clinical threat due to its resistance to multiple antibiotics and its enhanced virulence. Key outer membrane porins, OmpK35 and OmpK36, contribute to this resistance by limiting antibiotic influx and supporting bacterial survival. This study aimed to identify and evaluate phytochemicals targeting these porins using an integrated in silico -in vitro approach.</div><div>Over 100 phytocompounds were screened via molecular docking, revealing N-curcumin and myricetin as top candidates with binding affinities of -7.33 kcal/mol (OmpK35) and -7.58 kcal/mol (OmpK36), respectively. ADMET profiling supported their drug-likeness and safety. These compounds were further evaluated against reference and clinical Kp strains.</div><div>Minimum bactericidal concentration (MBC) assays showed that both N-curcumin and myricetin achieved effective killing at 7.5 mg/mL. Biofilm inhibition rates ranged from 40-48%, comparable to standard gentamicin. Crystal violet staining and microscopy confirmed significant biofilm disruption. Additionally, oxygen consumption rate (OCR) assays revealed substantial reductions in metabolic activity. Myricetin led to OCR decreases of 0.40-, 0.52-, and 0.35-fold against MTCC-432, ATCC-35657, and CL-1 strains, respectively.</div><div>Collectively, these findings highlight the dual antibacterial and antivirulence potential of N-curcumin and myricetin. Their ability to disrupt membrane protein function, inhibit biofilm formation, and impair bacterial respiration offers strong promise for their development as alternative therapeutics against MDR K. pneumoniae. This study supports the ongoing search for plant-derived compounds in the fight against resistant Gram-negative pathogens.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"12 ","pages":"Article 100167"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145693791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Terahertz (THz) imaging is emerging as a promising technique for early breast cancer detection due to its high sensitivity to tissue property variations. This paper presents a compact graphene-based patch antenna designed for broadband operation, occupying only 18 µm × 23 µm. The antenna achieves a wide bandwidth of 5.9 THz (3.1–9 THz) and a peak gain of 6.47 dBi without tissue loading, enabled by a full ground plane that ensures unidirectional radiation. To evaluate its performance for cancer detection, numerical breast phantoms with and without tumors were modeled. A significant S11 deviation of up to 16 dB was observed between healthy and cancerous tissue, indicating strong sensitivity to dielectric changes. Additionally, tumor localization was achieved by analyzing the spatial variation of the backscattered signal along the X and Y axes. The results confirm that the proposed antenna can detect minute tumors (∼10 µm radius) and effectively differentiate between malignant and healthy tissues, highlighting its potential for early-stage breast cancer screening.
太赫兹(THz)成像由于其对组织特性变化的高灵敏度而成为早期乳腺癌检测的一种有前途的技术。本文提出了一种紧凑的基于石墨烯的贴片天线,设计用于宽带操作,占地仅为18 μ m × 23 μ m。该天线可实现5.9太赫兹(3.1-9太赫兹)的宽带宽和6.47 dBi的峰值增益,无需组织加载,通过全地平面确保单向辐射。为了评估其在癌症检测方面的性能,对有肿瘤和无肿瘤的乳腺幻影进行了数值模拟。在健康组织和癌组织之间观察到显著的S11偏差高达16 dB,表明对介电变化具有很强的敏感性。此外,通过分析后向散射信号沿X和Y轴的空间变化,实现了肿瘤的定位。结果证实,该天线可以检测到微小的肿瘤(半径约10µm),并有效区分恶性和健康组织,突出了其早期乳腺癌筛查的潜力。
{"title":"Graphene-based terahertz antenna with enhanced backscatter sensitivity for early breast cancer localization","authors":"Anupma Gupta , Vipan Kumar , Sonu Bala Garg , Shonak Bansal , A.J.A. Al-Gburi","doi":"10.1016/j.nwnano.2025.100169","DOIUrl":"10.1016/j.nwnano.2025.100169","url":null,"abstract":"<div><div>Terahertz (THz) imaging is emerging as a promising technique for early breast cancer detection due to its high sensitivity to tissue property variations. This paper presents a compact graphene-based patch antenna designed for broadband operation, occupying only 18 µm × 23 µm. The antenna achieves a wide bandwidth of 5.9 THz (3.1–9 THz) and a peak gain of 6.47 dBi without tissue loading, enabled by a full ground plane that ensures unidirectional radiation. To evaluate its performance for cancer detection, numerical breast phantoms with and without tumors were modeled. A significant S11 deviation of up to 16 dB was observed between healthy and cancerous tissue, indicating strong sensitivity to dielectric changes. Additionally, tumor localization was achieved by analyzing the spatial variation of the backscattered signal along the X and Y axes. The results confirm that the proposed antenna can detect minute tumors (∼10 µm radius) and effectively differentiate between malignant and healthy tissues, highlighting its potential for early-stage breast cancer screening.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"12 ","pages":"Article 100169"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145750060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-30DOI: 10.1016/j.nwnano.2025.100168
Soban Imran Mulla, Naeem Mohammad, Pawan K. Khanna
Nanostructured molybdenum chalcogenides (MoSeTe), distinguished by their unique structures, have emerged as promising candidates for advanced technological applications due to their multifunctional properties. This investigation elucidates the synthesis of MoSeTe through a solvothermal approach, with stochiometric challenges and anisotropic morphology at nano-scale. The X-ray diffraction (XRD) analysis confirmed formation of well-defined nanostructures that exhibited distinct selenium (Se) and tellurium (Te) richness. The morphological aspects of as-prepared MoSeTe were studied using high-resolution transmission electron microscopy (HRTEM), field emission scanning electron microscopy (SEM) and atomic force microscopy (AFM). Functionality where expected was understood by Fourier transform infrared spectroscopy (FTIR). The MoSeTe/Ag/PVA nanocomposite films fabricated via the solution casting method demonstrated superior electromagnetic interference (EMI) shielding effectiveness in the X-band (8.2 to 12.4 GHz). Nanocomposite films with nano silver showed shielding effectiveness of about -37.06 and -45.14 dB for 1.0 mm and 2.0 mm thickness. This study highlights the scope of Mo-chalcogenides for their critical role as tailored nanostructures in advancing next-generation technologies for electronics and sustainable environmental applications.
{"title":"Synthesis, characterizations and EMI shielding behaviour of nanostructured molybdenum-chalcogenides (MoSeTe)","authors":"Soban Imran Mulla, Naeem Mohammad, Pawan K. Khanna","doi":"10.1016/j.nwnano.2025.100168","DOIUrl":"10.1016/j.nwnano.2025.100168","url":null,"abstract":"<div><div>Nanostructured molybdenum chalcogenides (MoSeTe), distinguished by their unique structures, have emerged as promising candidates for advanced technological applications due to their multifunctional properties. This investigation elucidates the synthesis of MoSeTe through a solvothermal approach, with stochiometric challenges and anisotropic morphology at nano-scale. The X-ray diffraction (XRD) analysis confirmed formation of well-defined nanostructures that exhibited distinct selenium (Se) and tellurium (Te) richness. The morphological aspects of as-prepared MoSeTe were studied using high-resolution transmission electron microscopy (HRTEM), field emission scanning electron microscopy (SEM) and atomic force microscopy (AFM). Functionality where expected was understood by Fourier transform infrared spectroscopy (FTIR). The MoSeTe/Ag/PVA nanocomposite films fabricated <em>via</em> the solution casting method demonstrated superior electromagnetic interference (EMI) shielding effectiveness in the X-band (8.2 to 12.4 GHz). Nanocomposite films with nano silver showed shielding effectiveness of about -37.06 and -45.14 dB for 1.0 mm and 2.0 mm thickness. This study highlights the scope of Mo-chalcogenides for their critical role as tailored nanostructures in advancing next-generation technologies for electronics and sustainable environmental applications.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"13 ","pages":"Article 100168"},"PeriodicalIF":0.0,"publicationDate":"2025-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145705842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-13DOI: 10.1016/j.nwnano.2025.100166
R.O. Okpuwhara, B.O. Oboirien
Polymer-based piezoelectric nanocomposites, serving as smart materials for devices, offer a sustainable alternative to conventional energy sources. These materials exhibit notable flexibility, lightweight characteristics, and integration advantages, surpassing non-polymeric counterparts and proving versatile in wearable technology. Furthermore, many polymeric piezoelectric materials boast biocompatibility, making them suitable for various biomedical applications. Among these, PVDF and related polymers stand out for their utility in piezoelectric devices, providing direct use as smart materials in transduction applications. This article summarises piezoelectric materials based on their operational principles, material properties, fabrication techniques, devices, and applications in electromechanical devices, alongside a historical overview of the earliest discoveries in piezoelectricity. Additionally, the role of polymer nanocomposite fibres in piezoelectricity is explored, particularly their preparation via electrospinning, which offers advantages such as a large specific surface area, controllable structure, ease of fabrication and low cost. The article also outlines the pioneering developments in electrospinning technology, including its principles and strategies, in the fabrication of piezoelectric materials.
{"title":"Piezoelectric polymer nanocomposite: Fabricating methods for materials and devices","authors":"R.O. Okpuwhara, B.O. Oboirien","doi":"10.1016/j.nwnano.2025.100166","DOIUrl":"10.1016/j.nwnano.2025.100166","url":null,"abstract":"<div><div>Polymer-based piezoelectric nanocomposites, serving as smart materials for devices, offer a sustainable alternative to conventional energy sources. These materials exhibit notable flexibility, lightweight characteristics, and integration advantages, surpassing non-polymeric counterparts and proving versatile in wearable technology. Furthermore, many polymeric piezoelectric materials boast biocompatibility, making them suitable for various biomedical applications. Among these, PVDF and related polymers stand out for their utility in piezoelectric devices, providing direct use as smart materials in transduction applications. This article summarises piezoelectric materials based on their operational principles, material properties, fabrication techniques, devices, and applications in electromechanical devices, alongside a historical overview of the earliest discoveries in piezoelectricity. Additionally, the role of polymer nanocomposite fibres in piezoelectricity is explored, particularly their preparation via electrospinning, which offers advantages such as a large specific surface area, controllable structure, ease of fabrication and low cost. The article also outlines the pioneering developments in electrospinning technology, including its principles and strategies, in the fabrication of piezoelectric materials.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"12 ","pages":"Article 100166"},"PeriodicalIF":0.0,"publicationDate":"2025-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145579308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-11DOI: 10.1016/j.nwnano.2025.100165
Mashrufa Akther , Andrea K. Quezada , Md Arafat Hossain , Julia I. Salas , Md. Mahmud Alam , Mohammed Jasim Uddin
Cardiovascular conditions remain the leading cause of death worldwide, driving a critical need for non-invasive, continuous, and dependable health monitoring results. Triboelectric nanogenerators have emerged as a groundbreaking technology enabling self-powered wearable sensors that convert natural biomechanical energy, such as heartbeat, pulse wave, and body motion, into electrical signals. The paper reviews the recent progress and development in TENG-based wearable sensors for cardiovascular monitoring, with a focus on monitoring particular and clinical healthcare. The working principles, advanced materials, structural designs, and integration with wireless data transmission, machine literacy, and bio-signal processing technologies are explored in this article. Operations, including heart rate shadowing, pulse rate analysis, blood pressure estimation, and electrocardiogram monitoring, are critically analyzed, along with their biocompatibility, safety, and long-term stability. Additionally, we addressed current challenges such as environmental continuity, signal reliability, energy operation, and proposed future directions emphasizing sustainable materials, AI-supported estimation, and green energy systems. The integration of TENG technology with innovative, wearable platforms represents a transformative step toward real-time, substantiated cardiovascular health monitoring, with broad and significant impact on telemedicine, preventative care, and implantable medical devices.
{"title":"Wearable triboelectric nanogenerators based sensors for human cardiovascular monitoring: progress and perspectives","authors":"Mashrufa Akther , Andrea K. Quezada , Md Arafat Hossain , Julia I. Salas , Md. Mahmud Alam , Mohammed Jasim Uddin","doi":"10.1016/j.nwnano.2025.100165","DOIUrl":"10.1016/j.nwnano.2025.100165","url":null,"abstract":"<div><div>Cardiovascular conditions remain the leading cause of death worldwide, driving a critical need for non-invasive, continuous, and dependable health monitoring results. Triboelectric nanogenerators have emerged as a groundbreaking technology enabling self-powered wearable sensors that convert natural biomechanical energy, such as heartbeat, pulse wave, and body motion, into electrical signals. The paper reviews the recent progress and development in TENG-based wearable sensors for cardiovascular monitoring, with a focus on monitoring particular and clinical healthcare. The working principles, advanced materials, structural designs, and integration with wireless data transmission, machine literacy, and bio-signal processing technologies are explored in this article. Operations, including heart rate shadowing, pulse rate analysis, blood pressure estimation, and electrocardiogram monitoring, are critically analyzed, along with their biocompatibility, safety, and long-term stability. Additionally, we addressed current challenges such as environmental continuity, signal reliability, energy operation, and proposed future directions emphasizing sustainable materials, AI-supported estimation, and green energy systems. The integration of TENG technology with innovative, wearable platforms represents a transformative step toward real-time, substantiated cardiovascular health monitoring, with broad and significant impact on telemedicine, preventative care, and implantable medical devices.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"12 ","pages":"Article 100165"},"PeriodicalIF":0.0,"publicationDate":"2025-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145528292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}