Next Nanotechnology最新文献

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Next Nanotechnology

Pub Date : 2026-01-01

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Next Nanotechnology

Pub Date : 2026-01-01

引用次数: 0

Next Nanotechnology

Pub Date : 2026-01-01

引用次数: 0

Next Nanotechnology

Pub Date : 2026-01-01

引用次数: 0

Next Nanotechnology

Pub Date : 2026-01-01

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Next Nanotechnology

Pub Date : 2026-01-01

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Next Nanotechnology

Pub Date : 2026-01-01

引用次数: 0

Light attenuation and optical absorption characteristics of graphene-chitosan nanomaterials-based quandary nanocomposites 石墨烯-壳聚糖纳米复合材料的光衰减和光吸收特性

Next Nanotechnology

Pub Date : 2025-12-30 DOI: 10.1016/j.nxnano.2025.100358

Sarah Aljelawy , Ehssan Al-Bermany , Ali Razzaq Abdulridha

Polymer-based graphene oxide nanocomposites represent an attractive class of materials due to their functional groups and wide range of applications in engineering and medicine. In this study, the interaction between nano-chitosan (CS) and graphene oxide (GO) nanosheets within polyvinylpyrrolidone (PVP) blended with polyacrylic acid (PAA) was investigated to fabricate two novel PVP–PAA–CS/GO nanocomposites. Fourier-transform infrared (FTIR) spectroscopy confirmed the presence of strong interfacial interactions and distinct functional groups. At the same time, X-ray diffraction (XRD) revealed a transition from amorphous to semicrystalline behavior after the incorporation of nanomaterials. Optical microscopy revealed the fracture surface characteristics and the fine dispersion of the components. UV–Vis spectroscopy demonstrated improved optical properties. Furthermore, the optical absorbance at 340 nm increased from 0.65 in PVP–PAA to 1.09 in PVP–PAA–CS/GO, indicating that ternary mix polymers and GO nanoparticles have formed a complex at around 300 nm, with a reduction of the optical band gap from 3.7 to 3.4 eV. The addition of nanomaterials enhanced the absorption behavior, dielectric constants (real and imaginary), and optical conductivity. Furthermore, the radiation attenuation of the composites improved significantly, with the half-value layer (HVL) increasing from 2.41 to 4.13 cm. These results highlight the potential of the prepared nanocomposites for diverse optoelectronic and light-shielding applications.

聚合物基氧化石墨烯纳米复合材料由于其功能基团和在工程和医学上的广泛应用而成为一类有吸引力的材料。在本研究中，研究了纳米壳聚糖（CS）与氧化石墨烯（GO）纳米片在聚乙烯吡咯烷酮（PVP）与聚丙烯酸（PAA）共混中相互作用，制备了两种新型PVP - PAA - CS/GO纳米复合材料。傅里叶红外光谱（FTIR）证实存在强的界面相互作用和明显的官能团。同时，x射线衍射（XRD）结果表明，纳米材料掺入后，材料由非晶向半晶转变。光学显微镜显示了断口表面特征和组分的精细分散。紫外可见光谱显示了改进的光学性能。此外，PVP-PAA在340 nm处的光学吸光度从0.65增加到1.09，表明三元混合聚合物和氧化石墨烯纳米粒子在300 nm附近形成了配合物，光学带隙从3.7减小到3.4 eV。纳米材料的加入增强了材料的吸收性能、介电常数（实介电常数和虚介电常数）和导电性。此外，复合材料的辐射衰减显著提高，半值层（HVL）从2.41 cm增加到4.13 cm。这些结果突出了所制备的纳米复合材料在各种光电和光屏蔽应用方面的潜力。

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Enhanced targeted delivery of cisplatin via folate and boron-modified magnetic nanoparticles: A promising approach for cervical cancer treatment 通过叶酸和硼修饰的磁性纳米颗粒增强顺铂的靶向递送：一种有前途的宫颈癌治疗方法

Next Nanotechnology

Pub Date : 2025-12-24 DOI: 10.1016/j.nxnano.2025.100352

Popsy Raj , Manoj M. Gadewar , Prashanth Gopala Krishna , Debashish Paramanick , Srilatha Rao , Lalithamba Haraluru Shankaraiah , N.P. Bhagya

This study aims on the development and evaluation of cisplatin-loaded nanoparticles (NPs) modified with folate (FA) and boron to enhance targeted drug delivery and therapeutic efficacy. FA and boron were employed as targeting ligands, while aldehyde sodium alginate (ASA) was used as a stabilizing modifier to improve the surface activity and stability of magnetic Fe₃O₄ nanoparticles synthesized via chemical co-precipitation. FA and boron were activated through interaction with NH₂-PEG-NH₂, through non-covalent chemical bonding, forming stable and water-soluble complexes. ASA was combined to Fe₃O₄ NPs after FA-PEG linkage via Schiff base formation. Subsequent substitution of chloride in cisplatin with the hydroxyl group of ASA yielded FA- and ASA-modified CIS-FA-ASA-MNPs, along with boron-coated counterparts. MTT assays demonstrated that cisplatin-loaded NPs significantly reduced cancer cell viability compared to other formulations, with CIS-loaded boron-coated NPs exhibiting pronounced cytotoxicity even at lower doses. The IC₅₀ value of CIS-loaded boron-coated NPs (0.61 µg/mL) was markedly lower than that of CIS-loaded FA-coated NPs (0.65 µg/mL) and free cisplatin (1.25 µg/mL), confirming superior anticancer potential. Enhanced apoptosis was observed due to improved nanocarrier internalization by CIS-loaded boron-coated NPs. These results highlight the promise of boron-coated, cisplatin-loaded NPs as a targeted therapeutic strategy for cervical cancer. The enhanced cytotoxicity compared with conventional formulations is attributed to improved cellular uptake and controlled drug release. Further in vivo and biological studies are warranted to validate the therapeutic efficacy and safety of this novel delivery system.

本研究旨在开发和评价叶酸和硼修饰的顺铂负载纳米颗粒（NPs），以增强靶向给药和治疗效果。以FA和硼为靶配体，以醛型海藻酸钠（ASA）为稳定改性剂，提高化学共沉淀法合成的磁性Fe₃O₄纳米颗粒的表面活性和稳定性。FA和硼通过与NH₂-PEG-NH₂的非共价化学键相互作用而活化，形成稳定的水溶性配合物。FA-PEG通过席夫碱形成键合，ASA与Fe₃O₄NPs结合。随后用ASA的羟基取代顺铂中的氯，得到FA-和ASA修饰的CIS-FA-ASA-MNPs，以及硼包覆的对应物。MTT试验表明，与其他制剂相比，装载顺铂的NPs显著降低了癌细胞活力，装载顺铂的硼包被NPs即使在较低剂量下也表现出明显的细胞毒性。cis负载的硼包覆NPs的IC₅₀值（0.61 µg/mL）明显低于cis负载的fa包覆NPs（0.65 µg/mL）和游离顺铂（1.25 µg/mL），证实了优越的抗癌潜力。由于负载cis的硼包被NPs改善了纳米载体的内化，观察到细胞凋亡增强。这些结果突出了硼包被的顺铂负载NPs作为宫颈癌靶向治疗策略的前景。与传统制剂相比，增强的细胞毒性归因于改善细胞摄取和控制药物释放。需要进一步的体内和生物学研究来验证这种新型给药系统的治疗效果和安全性。

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An overview of structural, optical, and magnetic properties of Mn-doped, Cu-doped, and (Mn, Cu)-codoped ZnS nanoparticles and its applications Mn掺杂、Cu掺杂和（Mn, Cu）共掺杂ZnS纳米粒子的结构、光学和磁性及其应用综述

Next Nanotechnology

Pub Date : 2025-12-23 DOI: 10.1016/j.nxnano.2025.100359

Pujarani Parida, Virendra Kumar Verma

Zinc Sulphide (ZnS) nanoparticles (NPs) are highly valued for their exceptional optical and magnetic properties, making them critical for applications in sensors, spintronics, and optoelectronic devices. This study explores the effects of Mn, Cu, and (Mn, Cu)-codoping on ZnS NPs prepared through wet chemical synthesis. It examines the variation of dopant concentrations that influence key characteristics such as crystalline size, band gap, and magnetic properties. The results show that Mn-doping widens the band gap from 3.32 eV to 4.51 eV, while Cu-doping further increases it from 2.97 eV to 4.99 eV, attributed to quantum confinement and the Burstein-Moss effect. Magnetically, pure and Cu-doped ZnS display ferromagnetism, whereas (Mn, Cu)-codoping leads to diminished ferromagnetic behavior due to reduced d⁰ magnetization. These improvements in band gap and magnetic properties highlight the potential of doped ZnS NPs for cutting-edge technological advancements.

硫化锌（ZnS）纳米颗粒（NPs）因其独特的光学和磁性而受到高度重视，这使得它们在传感器、自旋电子学和光电子器件中的应用至关重要。本研究探讨了Mn， Cu和（Mn, Cu）共掺杂对湿法化学合成的ZnS NPs的影响。它检查了影响关键特性的掺杂剂浓度的变化，如晶体尺寸、带隙和磁性能。结果表明，mn掺杂使带隙从3.32 eV扩大到4.51 eV， cu掺杂使带隙从2.97 eV进一步扩大到4.99 eV，这是由于量子约束和Burstein-Moss效应的作用。在磁性方面，纯ZnS和Cu掺杂ZnS表现出铁磁性，而（Mn, Cu）共掺杂由于磁化强度降低而导致铁磁性减弱。这些带隙和磁性能方面的改进突出了掺杂ZnS NPs在尖端技术进步方面的潜力。

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