Simarouba glauca leaves are rich in quassinoids, known for anticancer properties. This study aimed to develop a lipid-based solid dispersion of the quassinoid-enriched fraction (LBSD-QEF) to enhance permeability in MCF7 breast cancer cells.
Methods
LBSD-QEF of SG was prepared by hot homogenization using soy lecithin and Pluronic F68 (1:2) with varying concentrations of SGQEF.
Results
Out of the six developed formulations, the F5 (LBSD-QEF of SG) was chosen as the best one based on the zeta potential (-33.2 mV), polydispersity index (0.413), and an average mean particle size (275 nm). It comprises 50 mg of SG quassinoid enriched fraction in addition to 1:2 ratio of lipid (12.5 mg) and surfactant (25 mg). F5 remained stable for 3 months at 4 ± 2.0°C/50 % ± 5 % RH. In vitro drug release F5 (LBSD-QEF of SG) showed 76 % quassinoid release in the first hour and 80 % in the second through dialysis membrane. Cellular uptake of F5 in Caco-2 cells demonstrated strong FITC signal expression. Cytotoxicity studies showed F5 had an IC₅₀ of 12.45 µg/ml against MCF7 cells, outperforming SGQEF (IC₅₀ = 35.05 µg/ml) and crude methanol extract (IC₅₀ = 49.19 µg/ml).
Conclusion
The developed F5 (LBSD-QEF of Simarouba glauca) enhances membrane permeability and exhibits greater cytotoxicity in ER+ breast cancer cells.
{"title":"Development and characterization of lipid based solid dispersion of quassinoid enriched fraction of Simarouba glauca for enhanced lipid membrane permeability in MCF7 breast cancer cells","authors":"Vanitha Subburaj , Umaa Kuppuswamy , Sankar Veintraimuthu , Saran Vijay , Manju Velmurugan","doi":"10.1016/j.nxnano.2025.100350","DOIUrl":"10.1016/j.nxnano.2025.100350","url":null,"abstract":"<div><h3>Introduction</h3><div><em>Simarouba glauca</em> leaves are rich in quassinoids, known for anticancer properties. This study aimed to develop a lipid-based solid dispersion of the quassinoid-enriched fraction (LBSD-QEF) to enhance permeability in MCF7 breast cancer cells.</div></div><div><h3>Methods</h3><div>LBSD-QEF of SG was prepared by hot homogenization using soy lecithin and Pluronic F68 (1:2) with varying concentrations of SGQEF.</div></div><div><h3>Results</h3><div>Out of the six developed formulations, the F5 (LBSD-QEF of SG) was chosen as the best one based on the zeta potential (-33.2 mV), polydispersity index (0.413), and an average mean particle size (275 nm). It comprises 50 mg of SG quassinoid enriched fraction in addition to 1:2 ratio of lipid (12.5 mg) and surfactant (25 mg). F5 remained stable for 3 months at 4 ± 2.0°C/50 % ± 5 % RH. <em>In vitro</em> drug release F5 (LBSD-QEF of SG) showed 76 % quassinoid release in the first hour and 80 % in the second through dialysis membrane. Cellular uptake of F5 in Caco-2 cells demonstrated strong FITC signal expression. Cytotoxicity studies showed F5 had an IC₅₀ of 12.45 µg/ml against MCF7 cells, outperforming SGQEF (IC₅₀ = 35.05 µg/ml) and crude methanol extract (IC₅₀ = 49.19 µg/ml).</div></div><div><h3>Conclusion</h3><div>The developed F5 (LBSD-QEF of <em>Simarouba glauca</em>) enhances membrane permeability and exhibits greater cytotoxicity in ER+ breast cancer cells.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100350"},"PeriodicalIF":0.0,"publicationDate":"2025-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145840923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-19DOI: 10.1016/j.nxnano.2025.100351
B. Jyothish , John Jacob
This study synthesizes silver-doped zinc ferrite nanoparticles, comprehensively characterized using XRD, FESEM, UV-Vis, and FTIR, revealing their structural and optical properties. In vitro cytotoxicity assays on A549 lung cancer cells demonstrated a potent anticancer effect, with an LC50 of 7.1 µg/mL and a high selective index (SI) of 25. Mechanistically, the nanoparticles induced G0/G1 cell cycle arrest, significantly inhibited cell migration, and triggered enhanced reactive oxygen species (ROS) production, leading to apoptosis. Furthermore, the nanoparticles exhibited promising antioxidant properties by boosting catalase and superoxide dismutase (SOD) activities, coupled with the upregulation of p53 and p21 proteins. Leveraging artificial intelligence, this research aims to predict future applications, including biofilm inhibition, tissue engineering compatibility, enhanced anticancer efficacy through targeted drug delivery, and expanded therapeutic horizons. By integrating experimental data with AI-driven modeling, this work seeks to unlock the full potential of silver-doped zinc ferrite nanoparticles for advanced biomedical applications.
{"title":"Artificial intelligence-driven insights into silver-doped zinc ferrite (SI=25): Advancing biofilm control, drug delivery, and tissue engineering for cancer therapy","authors":"B. Jyothish , John Jacob","doi":"10.1016/j.nxnano.2025.100351","DOIUrl":"10.1016/j.nxnano.2025.100351","url":null,"abstract":"<div><div>This study synthesizes silver-doped zinc ferrite nanoparticles, comprehensively characterized using XRD, FESEM, UV-Vis, and FTIR, revealing their structural and optical properties. In vitro cytotoxicity assays on A549 lung cancer cells demonstrated a potent anticancer effect, with an LC50 of 7.1 µg/mL and a high selective index (SI) of 25. Mechanistically, the nanoparticles induced G0/G1 cell cycle arrest, significantly inhibited cell migration, and triggered enhanced reactive oxygen species (ROS) production, leading to apoptosis. Furthermore, the nanoparticles exhibited promising antioxidant properties by boosting catalase and superoxide dismutase (SOD) activities, coupled with the upregulation of p53 and p21 proteins. Leveraging artificial intelligence, this research aims to predict future applications, including biofilm inhibition, tissue engineering compatibility, enhanced anticancer efficacy through targeted drug delivery, and expanded therapeutic horizons. By integrating experimental data with AI-driven modeling, this work seeks to unlock the full potential of silver-doped zinc ferrite nanoparticles for advanced biomedical applications.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100351"},"PeriodicalIF":0.0,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145799933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-19DOI: 10.1016/j.nxnano.2025.100357
Md Maruf Ahmed , Xiang Jiahong , Zheng Wang , Zheng Zhang , Yingzhuo Shen , Seytkhan Azat , Qin Xu
The design and tuning of metal–organic frameworks (MOFs) have emerged as a powerful strategy for designing advanced sensors that enable accurate and rapid analyte detection. In this study, the effect of several organic linkers (1,4-benzene dicarboxylic acid, benzene-1,3,5-tricarboxylate acid, biphenyl-4,4′-dicarboxylate acid, and 1,3,5-Tris(4-carboxyphenyl) benzene) on the morphological and structural properties of Zn-MOFs has been studied. Additionally, the as-prepared Zn-MOFs were utilized to investigate their BPA sensing properties. Ligand tuning enhances sensor performance by introducing functional groups that promote stronger analyte interactions and faster signal response. The Zn-BPDC (biphenyl-4,4′-dicarboxylate) promotes robust π-π stacking interactions between the aromatic rings of BPA and the BPDC ligands, thereby increasing sensing capabilities. Furthermore, it promotes the formation of a needle-shaped structure, which has superior BPA sensing capabilities compared to other Zn-MOFs. The current response of the Zn-BPDC/GCE exhibited a robust linear correlation with BPA concentrations from 0.05 to 6 μM and a low detection limit of 0.033 μM with excellent stability. The practical applicability of the sensor was evaluated using milk, drinking water, and tap water, achieving impressive recovery of BPA between 94.1 % and 105.6 %. Thus, the designed sensor may serve as a viable alternative for the identification of BPA as well as estrogenic substrates.
{"title":"Ligands tuned Zn-MOFs with superior electrocatalytic performance for BPA sensor construction","authors":"Md Maruf Ahmed , Xiang Jiahong , Zheng Wang , Zheng Zhang , Yingzhuo Shen , Seytkhan Azat , Qin Xu","doi":"10.1016/j.nxnano.2025.100357","DOIUrl":"10.1016/j.nxnano.2025.100357","url":null,"abstract":"<div><div>The design and tuning of metal–organic frameworks (MOFs) have emerged as a powerful strategy for designing advanced sensors that enable accurate and rapid analyte detection. In this study, the effect of several organic linkers (1,4-benzene dicarboxylic acid, benzene-1,3,5-tricarboxylate acid, biphenyl-4,4′-dicarboxylate acid, and 1,3,5-Tris(4-carboxyphenyl) benzene) on the morphological and structural properties of Zn-MOFs has been studied. Additionally, the as-prepared Zn-MOFs were utilized to investigate their BPA sensing properties. Ligand tuning enhances sensor performance by introducing functional groups that promote stronger analyte interactions and faster signal response. The Zn-BPDC (biphenyl-4,4′-dicarboxylate) promotes robust π-π stacking interactions between the aromatic rings of BPA and the BPDC ligands, thereby increasing sensing capabilities. Furthermore, it promotes the formation of a needle-shaped structure, which has superior BPA sensing capabilities compared to other Zn-MOFs. The current response of the Zn-BPDC/GCE exhibited a robust linear correlation with BPA concentrations from 0.05 to 6 μM and a low detection limit of 0.033 μM with excellent stability. The practical applicability of the sensor was evaluated using milk, drinking water, and tap water, achieving impressive recovery of BPA between 94.1 % and 105.6 %. Thus, the designed sensor may serve as a viable alternative for the identification of BPA as well as estrogenic substrates.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100357"},"PeriodicalIF":0.0,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145799938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-18DOI: 10.1016/j.nxnano.2025.100341
Suvarshitha Pusuluru , Sai Kumar Punna , Karrun Velmurugan , Melvin S. Samuel , Selvarajan Ethiraj , Needhidasan Santhanam
Polyethylene terephthalate (PET), a widely used polymer in transparent bottles for water, sanitizers, and other liquids, has seen a surge in consumption, particularly during the COVID-19 pandemic. This increase has resulted in a significant rise in PET-based waste, posing serious environmental and waste management challenges. PET waste, with approximately 11 % fixed carbon, low ash, and 30 % oxygen content, presents a promising raw material for the synthesis of activated carbon and other nanoporous carbon materials. However, conventional methods for converting PET into carbonaceous sorbents often yield limited output and face competition from other recycling pathways, rendering large-scale application impractical. This review critically examines both traditional and emerging techniques for activating PET, comparing its suitability and performance with other polymeric wastes, such as scrap tires. The broader context of plastic waste management is discussed, highlighting its non-biodegradable nature, toxic byproduct release, and impact on ecosystems and human health. Innovative approaches such as recycling and upcycling plastic into carbon-based nanomaterials (CBMs)—including carbon quantum dots, nanoparticles, nanotubes, graphene, and 3D porous carbons—are explored as sustainable alternatives. These plastic waste-derived carbon materials (PWCMs) offer high-value applications in clean energy storage, environmental remediation, and green technologies. The review also identifies eco-friendly production methods, aiming to bridge the gap between academic research and industrial practices. In addressing global energy demands and environmental degradation, PWCMs are positioned as key players in the transition to a circular economy and the development of renewable energy solutions. By consolidating recent advancements and outlining future research directions, this study underscores the potential of PET and other plastic wastes to serve as sustainable feedstocks for high-performance materials, encouraging innovative recycling strategies and contributing to the global effort against plastic pollution.
{"title":"Transforming polyethylene terephthalate (PET) into carbon-based nanomaterials: Advancing sustainable solutions for green energy and environmental remediation","authors":"Suvarshitha Pusuluru , Sai Kumar Punna , Karrun Velmurugan , Melvin S. Samuel , Selvarajan Ethiraj , Needhidasan Santhanam","doi":"10.1016/j.nxnano.2025.100341","DOIUrl":"10.1016/j.nxnano.2025.100341","url":null,"abstract":"<div><div>Polyethylene terephthalate (PET), a widely used polymer in transparent bottles for water, sanitizers, and other liquids, has seen a surge in consumption, particularly during the COVID-19 pandemic. This increase has resulted in a significant rise in PET-based waste, posing serious environmental and waste management challenges. PET waste, with approximately 11 % fixed carbon, low ash, and 30 % oxygen content, presents a promising raw material for the synthesis of activated carbon and other nanoporous carbon materials. However, conventional methods for converting PET into carbonaceous sorbents often yield limited output and face competition from other recycling pathways, rendering large-scale application impractical. This review critically examines both traditional and emerging techniques for activating PET, comparing its suitability and performance with other polymeric wastes, such as scrap tires. The broader context of plastic waste management is discussed, highlighting its non-biodegradable nature, toxic byproduct release, and impact on ecosystems and human health. Innovative approaches such as recycling and upcycling plastic into carbon-based nanomaterials (CBMs)—including carbon quantum dots, nanoparticles, nanotubes, graphene, and 3D porous carbons—are explored as sustainable alternatives. These plastic waste-derived carbon materials (PWCMs) offer high-value applications in clean energy storage, environmental remediation, and green technologies. The review also identifies eco-friendly production methods, aiming to bridge the gap between academic research and industrial practices. In addressing global energy demands and environmental degradation, PWCMs are positioned as key players in the transition to a circular economy and the development of renewable energy solutions. By consolidating recent advancements and outlining future research directions, this study underscores the potential of PET and other plastic wastes to serve as sustainable feedstocks for high-performance materials, encouraging innovative recycling strategies and contributing to the global effort against plastic pollution.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100341"},"PeriodicalIF":0.0,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145799941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bone tissue engineering is an applied field of biomedical sciences which analyzes implantable bone substitutes for critical skeletal defects including geriatric decay and accidental injuries. For several years metallic drug-eluting implants have proven extraordinary prominence in orthopedics and dentistry for controlled drug release. The incorporated chemicals promote osteoconduction and angiogenesis, impeding bacterial infection and modulates host body reaction. Various types of proteins, growth factors, enzymes, anti-inflammatory drugs, non-viral genes (DNAs, RNAs) are nowadays used to treat different musculoskeletal syndromes. The scaffolds can be fabricated with different biomaterials such as biopolymers like collagen, chitosan, bioceramics like hydroxyapatite, nanocapsules, nanofibers, microcapsule, microsphere and also gel and film-based materials like hydrogel, polyelectrolyte films etc. Sustained local delivery of therapeutic agents via functionalized implant material has the potential to address the common intrinsic challenges of systematic drug delivery such as inadequate physiological stability.
This mini-review examines advancements in bone tissue engineering, focusing on metallic drug-eluting implants and innovative scaffold materials that support osteogenesis. By integrating localized drug delivery systems, these technologies enhance healing, reduce infection, and improve implant stability for complex bone injuries and degenerative conditions.
{"title":"Bone tissue engineering and drug-eluting implants for enhanced bone regeneration: An update","authors":"Maitrayee Banerjee Mukherjee , Oly Banerjee , Siddhartha Singh , Sandip Mukherjee","doi":"10.1016/j.nxnano.2025.100349","DOIUrl":"10.1016/j.nxnano.2025.100349","url":null,"abstract":"<div><div>Bone tissue engineering is an applied field of biomedical sciences which analyzes implantable bone substitutes for critical skeletal defects including geriatric decay and accidental injuries. For several years metallic drug-eluting implants have proven extraordinary prominence in orthopedics and dentistry for controlled drug release. The incorporated chemicals promote osteoconduction and angiogenesis, impeding bacterial infection and modulates host body reaction. Various types of proteins, growth factors, enzymes, anti-inflammatory drugs, non-viral genes (DNAs, RNAs) are nowadays used to treat different musculoskeletal syndromes. The scaffolds can be fabricated with different biomaterials such as biopolymers like collagen, chitosan, bioceramics like hydroxyapatite, nanocapsules, nanofibers, microcapsule, microsphere and also gel and film-based materials like hydrogel, polyelectrolyte films etc. Sustained local delivery of therapeutic agents <em>via</em> functionalized implant material has the potential to address the common intrinsic challenges of systematic drug delivery such as inadequate physiological stability.</div><div>This mini-review examines advancements in bone tissue engineering, focusing on metallic drug-eluting implants and innovative scaffold materials that support osteogenesis. By integrating localized drug delivery systems, these technologies enhance healing, reduce infection, and improve implant stability for complex bone injuries and degenerative conditions.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100349"},"PeriodicalIF":0.0,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145799942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-18DOI: 10.1016/j.nxnano.2025.100347
Divyam Mishra , Bhavishya Chaturvedi , Vishal Soni , Dhairya Valecha , Megha Goel , Jamilur R. Ansari
{"title":"Corrigendum to “Impact of bridging the gap between Artificial Intelligence and nanomedicine in healthcare” [Next Nanotechnol. 8 (2025) 100203]","authors":"Divyam Mishra , Bhavishya Chaturvedi , Vishal Soni , Dhairya Valecha , Megha Goel , Jamilur R. Ansari","doi":"10.1016/j.nxnano.2025.100347","DOIUrl":"10.1016/j.nxnano.2025.100347","url":null,"abstract":"","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100347"},"PeriodicalIF":0.0,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145799934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Peripheral neuropathic pain remains a major clinical challenge due to its multifactorial pathophysiology and the limited efficacy of available therapies. Gabapentin, an anticonvulsant agent, has shown potential in alleviating neuropathic pain symptoms; however, its therapeutic performance is restricted by poor aqueous solubility and dose-dependent adverse effects. Nano emulsion-based delivery systems offer a promising strategy to overcome these limitations by enhancing solubility, stability, and targeted delivery to peripheral nerves. In the present study, the authors developed a gabapentin-loaded nanoemulsion. The developed nanoemulsion was optimized through systematic excipient screening, construction of pseudo-ternary phase diagrams, and comprehensive evaluation of physicochemical and performance parameters. The optimized formulation demonstrated a cumulative drug release with 97.42 ± 1.23 % (n = 3) within 2 h, indicating rapid and efficient drug release kinetics. Transmission electron microscopy confirmed the uniform nanoscale droplet morphology, while rheological analysis revealed favorable viscosity and spreadability characteristics. The ex vivo skin permeation study revealed a marked improvement in transdermal delivery of gabapentin, which was further supported by FT-IR and DSC results showing disruption of the skin’s lipid bilayer after treatment. The observations from confocal laser scanning microscopy confirmed that the formulation enabled deeper penetration of the drug into the skin layers. These results indicate that the optimized gabapentin nanoemulsion could enhance bioavailability and enable targeted delivery, offering promise for the management of peripheral neuropathic pain. However, the authors also highlight that in vivo efficacy studies will be essential to validate these findings and fully establish the therapeutic potential of the microemulsion.
{"title":"Gabapentin loaded nano-emulsion for the effective treatment of peripheral neurological pain: Formulation, characterization, and ex vivo studies","authors":"Bhavna , Mohit Kumar , Ayesha Siddiqui , Syed Mahmood , Pooja Jain , M. Aamir Mirza , Zeenat Iqbal","doi":"10.1016/j.nxnano.2025.100354","DOIUrl":"10.1016/j.nxnano.2025.100354","url":null,"abstract":"<div><div>Peripheral neuropathic pain remains a major clinical challenge due to its multifactorial pathophysiology and the limited efficacy of available therapies. Gabapentin, an anticonvulsant agent, has shown potential in alleviating neuropathic pain symptoms; however, its therapeutic performance is restricted by poor aqueous solubility and dose-dependent adverse effects. Nano emulsion-based delivery systems offer a promising strategy to overcome these limitations by enhancing solubility, stability, and targeted delivery to peripheral nerves. In the present study, the authors developed a gabapentin-loaded nanoemulsion. The developed nanoemulsion was optimized through systematic excipient screening, construction of pseudo-ternary phase diagrams, and comprehensive evaluation of physicochemical and performance parameters. The optimized formulation demonstrated a cumulative drug release with 97.42 ± 1.23 % (n = 3) within 2 h, indicating rapid and efficient drug release kinetics. Transmission electron microscopy confirmed the uniform nanoscale droplet morphology, while rheological analysis revealed favorable viscosity and spreadability characteristics. The <em>ex vivo</em> skin permeation study revealed a marked improvement in transdermal delivery of gabapentin, which was further supported by FT-IR and DSC results showing disruption of the skin’s lipid bilayer after treatment. The observations from confocal laser scanning microscopy confirmed that the formulation enabled deeper penetration of the drug into the skin layers. These results indicate that the optimized gabapentin nanoemulsion could enhance bioavailability and enable targeted delivery, offering promise for the management of peripheral neuropathic pain. However, the authors also highlight that <em>in vivo</em> efficacy studies will be essential to validate these findings and fully establish the therapeutic potential of the microemulsion.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100354"},"PeriodicalIF":0.0,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145799939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-16DOI: 10.1016/j.nxnano.2025.100355
Sarah Susan Jolly , A.R. Twinkle , B.S. Arun Sasi , R. Reshma
Photocatalytic hydrogen production offers a sustainable path to clean energy, yet conventional approaches are limited by inefficiencies in light absorption and charge separation. This review explores how principles from quantum optics—such as coherence, entanglement, and nonclassical photon statistics—can fundamentally enhance photocatalytic processes. We delve into three key themes: (1) coherence-enhanced charge separation and exciton dynamics, (2) the impact of nonclassical light sources (e.g., squeezed and entangled photons) on catalytic efficiency, and (3) quantum optical control of light–matter interaction may offer new mechanisms for selective excitation, suppressed recombination, and low-intensity hydrogen evolution, though these remain largely theoretical or at proof-of-principle stages. Challenges in materials integration, decoherence management, and photonic engineering are critically examined. This review highlights a promising frontier in solar fuels research, where quantum light is not just a tool, but a resource for redefining the limits of photocatalytic efficiency.
{"title":"Quantum optics in photocatalytic hydrogen production: Light-matter interaction at the quantum scale","authors":"Sarah Susan Jolly , A.R. Twinkle , B.S. Arun Sasi , R. Reshma","doi":"10.1016/j.nxnano.2025.100355","DOIUrl":"10.1016/j.nxnano.2025.100355","url":null,"abstract":"<div><div>Photocatalytic hydrogen production offers a sustainable path to clean energy, yet conventional approaches are limited by inefficiencies in light absorption and charge separation. This review explores how principles from quantum optics—such as coherence, entanglement, and nonclassical photon statistics—can fundamentally enhance photocatalytic processes. We delve into three key themes: (1) coherence-enhanced charge separation and exciton dynamics, (2) the impact of nonclassical light sources (e.g., squeezed and entangled photons) on catalytic efficiency, and (3) quantum optical control of light–matter interaction may offer new mechanisms for selective excitation, suppressed recombination, and low-intensity hydrogen evolution, though these remain largely theoretical or at proof-of-principle stages. Challenges in materials integration, decoherence management, and photonic engineering are critically examined. This review highlights a promising frontier in solar fuels research, where quantum light is not just a tool, but a resource for redefining the limits of photocatalytic efficiency.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100355"},"PeriodicalIF":0.0,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145799875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-16DOI: 10.1016/j.nxnano.2025.100353
Ka Kin Wang, Pui Vun Chai
Water deterioration has become increasingly severe due to industrialization and the growth of human populations. Different types of emerging pollutants have also created immense stress on the environment, with some showing strong resistance to conventional biological treatment systems. As a result, more sophisticated water and wastewater treatment technologies are required to ensure safe and reliable water supplies. Advanced oxidation processes (AOPs) have proven effective by generating strong reactive oxygen species, such as hydroxyl radicals, that can degrade highly resistant pollutants. These radicals may be produced through ultraviolet radiation, ultrasound, or electric power in the presence of appropriate catalysts. Incorporating nanotechnology as a catalyst in AOPs offers significant advantages, as nanomaterials exhibit high stability, large surface area, strong reactivity, and recyclability. Such properties not only enhance the purification of water for human and environmental health but also reduce the reliance on chemical additives, improve energy efficiency, and promote the sustainable use of resources. Collectively, these advances contribute to cleaner water access, more responsible treatment practices, and a lower environmental footprint that supports both ecosystem protection and climate resilience.
{"title":"Advancements in nanotechnology for enhancing the efficiency of advanced oxidation processes: A review","authors":"Ka Kin Wang, Pui Vun Chai","doi":"10.1016/j.nxnano.2025.100353","DOIUrl":"10.1016/j.nxnano.2025.100353","url":null,"abstract":"<div><div>Water deterioration has become increasingly severe due to industrialization and the growth of human populations. Different types of emerging pollutants have also created immense stress on the environment, with some showing strong resistance to conventional biological treatment systems. As a result, more sophisticated water and wastewater treatment technologies are required to ensure safe and reliable water supplies. Advanced oxidation processes (AOPs) have proven effective by generating strong reactive oxygen species, such as hydroxyl radicals, that can degrade highly resistant pollutants. These radicals may be produced through ultraviolet radiation, ultrasound, or electric power in the presence of appropriate catalysts. Incorporating nanotechnology as a catalyst in AOPs offers significant advantages, as nanomaterials exhibit high stability, large surface area, strong reactivity, and recyclability. Such properties not only enhance the purification of water for human and environmental health but also reduce the reliance on chemical additives, improve energy efficiency, and promote the sustainable use of resources. Collectively, these advances contribute to cleaner water access, more responsible treatment practices, and a lower environmental footprint that supports both ecosystem protection and climate resilience.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100353"},"PeriodicalIF":0.0,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145799876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Green nanotechnology offers a sustainable, cost-effective, and environmentally beneficial way to create nanoparticles from organic materials rather than raw ones. Specifically, bio-waste such as fruit peels can be utilized to synthesize nanoparticles by extraction of their beneficial biomolecules. The present research reveals the green synthesis approach to produce copper oxide nanoparticles for antibacterial application by using the aqueous mango (Mangifera indica) (MGI) peel extract. The phytochemical testing of mango peel extract confirmed the presence of tannins, polyphenols, alkaloids, saponins, flavonoids, terpenoids, reducing sugars, and glycosides. The UV–visible and UV-DRS studies showed the maximum absorbance and energy gap value as 425 nm and 2.08 eV, respectively. The XRD pattern confirmed the formation of crystalline CuO NPs with a tenorite structure. The scanning electron microscopy confirmed nearly spherical CuO NPs. The antibacterial efficacy of the green CuO NPs was evaluated against the Gram-positive Bacillus Cereus and Gram-negative Escherichia coli bacteria. The maximum zone of inhibition of 11.6 mm was recorded for the calcined CuO NPs against the Gram-positive bacterial strain Bacillus Cereus. The synthesized CuO NPs proved to be potential candidates as antibacterial agents. The CuO NPs were also used for the sensor studies of lithium. The modified electrode's electrocatalytic response for Li sensing was found to be extremely concentration sensitive, as the anodic oxidation current rose progressively with the concentration of Li. The photocatalytic degradation study of Fast Orange dye revealed an absorbance at 495 nm during the time period of 90 min and exhibits a maximum percentage of 74 % absorbance value. The synthesized green CuO NPs proved to have multifunctional nature for futuristic applications.
{"title":"Exploring mango (Mangifera indica) fruit peel extract mediated bio-preparation of CuO nanoparticles for biological, dye degradation and sensor applications","authors":"Hannah Numa , T.M. Sharanakumar , Lydia Yalambing , T. Naveen Kumar , K.V. Anasuya , C.R. Ravikumar , H.C. Ananda Murthy","doi":"10.1016/j.nxnano.2025.100356","DOIUrl":"10.1016/j.nxnano.2025.100356","url":null,"abstract":"<div><div>Green nanotechnology offers a sustainable, cost-effective, and environmentally beneficial way to create nanoparticles from organic materials rather than raw ones. Specifically, bio-waste such as fruit peels can be utilized to synthesize nanoparticles by extraction of their beneficial biomolecules. The present research reveals the green synthesis approach to produce copper oxide nanoparticles for antibacterial application by using the aqueous mango (<em>Mangifera indica</em>) (MGI) peel extract. The phytochemical testing of mango peel extract confirmed the presence of tannins, polyphenols, alkaloids, saponins, flavonoids, terpenoids, reducing sugars, and glycosides. The UV–visible and UV-DRS studies showed the maximum absorbance and energy gap value as 425 nm and 2.08 eV, respectively. The XRD pattern confirmed the formation of crystalline CuO NPs with a tenorite structure. The scanning electron microscopy confirmed nearly spherical CuO NPs. The antibacterial efficacy of the green CuO NPs was evaluated against the Gram-positive <em>Bacillus Cereus</em> and Gram-negative <em>Escherichia coli</em> bacteria. The maximum zone of inhibition of 11.6 mm was recorded for the calcined CuO NPs against the Gram-positive bacterial strain <em>Bacillus Cereus</em>. The synthesized CuO NPs proved to be potential candidates as antibacterial agents. The CuO NPs were also used for the sensor studies of lithium. The modified electrode's electrocatalytic response for Li sensing was found to be extremely concentration sensitive, as the anodic oxidation current rose progressively with the concentration of Li. The photocatalytic degradation study of Fast Orange dye revealed an absorbance at 495 nm during the time period of 90 min and exhibits a maximum percentage of 74 % absorbance value. The synthesized green CuO NPs proved to have multifunctional nature for futuristic applications.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100356"},"PeriodicalIF":0.0,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145799936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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