Oral Oncology Extra最新文献

The condition of melanoma involving the mucosa on mandible and both maxilla simultaneously is very rare. This report presents such a case from a 72-year-old female.

Rhabdomyosarcoma (RMS) is an aggressive malignant neoplasm of skeletal muscle origin that represents 50% of all soft tissue sarcomas in childhood, with most cases occurring in the head and neck. Within the microscopical patterns, the embryonal type is the most frequent in the oral cavity. This article describes a case of an embryonal rhabdomyosarcoma in a child. Clinical, imaginological, histological and immunohistochemical aspects are discussed.

Follicular dendritic cell sarcoma (FDCS) is a rare intermediate grade malignant neoplasm of reticular dendritic origin. Castleman’s disease (CD) represents a non-neoplastic lymphoproliferative disorder with various clinical and morphological features. FDCS has been reported to be associated with CD. In this article, we describe the first case of follicular dendritic cell sarcoma associated with Castleman’s disease presenting in the oral cavity.

A very rare case of epithelioid hemangioendothelioma (EH) in the tongue is reported. The immunohistochemical studies for Factor VIII, proliferating cell nuclear antigen (PCNA) and vascular endothelial growth factor (VEGF) were performed. The tumour cell kinetics in EH was evaluated by PCNA immunohistochemistry. PCNA labeling index in the tumour was 57.0%. Furthermore, strong immunohistochemical expression of VEGF was recognized in the cytoplasm of tumour cells. The intense expression of VEGF in EH may indicate its aggressive proliferative activity and metastatic behavior.

Odontogenic lesions of hamartomatous origin may occasionally result in delayed tooth eruption. However, the lack of a universally accepted terminology for such lesions may hinder their recognition. We present a case showing delay in the eruption of permanent mandibular second molars bilaterally; histopathologic examination of the excised opercula revealed features reminiscent of peripheral odontogenic fibroma with an abundance of stellate giant cells. After review and analysis of the pertinent literature, the lesions were diagnosed as dental follicular hamartomas to reflect their odontogenic (dental follicular) origin and hamartomatous nature.

Primary (extranodal) non-Hodgkin’s lymphoma (NHL) of the oral cavity is relatively rare. We report a case of NHL involving the left anterior mandibular gingiva of a 56-year-old man. He was initially treated with antibiotics and root canal therapy of the lower lateral incisor as there was a history of trauma to this area. The adjacent lateral incisor tested non-vital. However, after 2 weeks of antibiotic therapy the swelling increased in size and an incisional biopsy was performed. A diagnosis of non-Hodgkin’s lymphoma, large-B cell type was rendered. The patient was then referred to medical oncology for staging work-up and treatment. A course of six cycles of CHOP chemotherapy (Cyclophosphamide, Hydroxydoxorubicin, Oncovin, Prednisone) and radiotherapy were scheduled. There was a complete response upon completion of the combined chemotherapy and radiotherapy. One year later, the patient developed a 2 × 2-cm, painless, firm, fixed mass of the left anterior maxillary vestibule. No additional findings were noted clinically. Magnetic resonance imaging (MRI) confirmed the clinical findings and there was no suspicion of disease elsewhere. Pathologic examination revealed non-Hodgkin’s lymphoma, B-cell type. This lesion was identical morphologically and immunophenotypically to the initial mandibular lesion. Complete radiographic staging detected no other sites of disease. The bone marrow was not involved. The lesion rapidly normalized after six cycles of Fludara, Novantrone and Mabthera chemotherapy and one cycle of Cytarabine (Ara-C). Partial remission was achieved, but the patient died of disseminated disease, 12 months after relapse. There was an associated HCV infection, which may have played a role in the fatal outcome.

Myoepithelial carcinomas are not as rare as is generally believed, but they are simply not well recognized. Those arising in the oral cavity and exhibiting pure spindle cell morphology are often difficult to diagnose primarily and are likely to be misinterpreted as other more common spindle cell lesions of the oral cavity. Use of ancillary studies like Electron microscopy (EM) and immunohistochemistry (IHC) is very much essential for confirmation of diagnosis. Here we present two such cases of spindle cell myoepithelial carcinoma, which were initially misinterpreted as nerve sheath tumours after IHC and later presented with multiple recurrences and lymph node metastasis.