Oral Oncology Extra最新文献

Orofacial complications of leukemia include lymphadenopathy, gingival bleeding, petechiae, ulceration, gingival enlargement and infections. Chronic lymphocytic leukemia (CLL) is the most prevalent type of adult lymphoproliferative disorder, but oral manifestations are uncommon. We describe a rare case of extensive mandibular infiltration in chronic lymphocytic leukemia.

Carcinosarcoma, which consists of both carcinomatous and sarcomatous tissues, is extremely rare in the oral cavity. An 80-year-old woman was referred to us, complaining of a painful, polypoidal, and rapidly growing mass at the lateral border of her tongue. We performed an excision with adequate margin around the stalk of the polyp. The mass was histologically and immunohistochemically diagnosed as a carcinosarcoma composed of both squamous cell carcinoma and rhabdomyosarcoma which is, to our knowledge, the first such case in the tongue.

Papillary cystadenocarcinoma is an extremely rare malignant neoplasm characterized by cysts and papillary endophytic projections. It was first defined in 1991 by WHO. We presented a case of papillary cystadenocarinoma arising from the submandibular gland in a 78-year-old male patient, and discussed the clinical, histopathological and treatment features of this rare entity in the light of the current literature.

Kaposiform hemangioendothelioma is a rare locally aggressive vascular neoplasm of infancy and childhood. An 18-month-old Chinese infant with a rapidly enlarging mass in the neck was presented here. Physical examination revealed a dark-red, firm mass measuring 7.0 × 4.5 cm in the anterior neck. No associated with KMS was observed despite its size. Morphologically, the tumor consisted of dense spindle cells with a nodular growth pattern, with hypocellular areas of hyalinized fibrous stroma. Immunohistochemically, both spindle and epithelioid were immunoreactive to CD34, CD31 and UEA-1, while negative to GLUT1, EMA, cytokeratin or S-100 protein. The well-formed capillaries and mature vessels but not spindle tumor cell showed reactivity for FVIII-Rag. α-SMA were detected in pericysts surrounding spindle cells. Large vessels in the tumor were positive for VEGFR3. Recurrence occurred 6 month after first operation. Wide resection was performed a second time, the patient was still alive during the 7-year follow-up period.

Verrucous carcinoma (VC) a low-grade variant of squamous cell carcinoma (SCC) with specific clinical, morphologic and cytokinetic features is amongst the rarest of all oral cancers. A hybrid VC is a non-verrucous SCC that arises synchronously with the VC. We report a case of a monstrous exophytic tumor in the oral cavity. Histologic examination revealed distinct discrepancy to clinical observation. After review of the literature pathogenesis, histopathology and therapeutic options are discussed. The differential diagnosis of VC remains difficult and requires clinical and pathologic data confrontation. As the malignant behaviour of hybrid VC is confined to the non-VC component, careful examination of these tumors is recommended.

Rhabdomyosarcoma (RMS) is an aggressive malignant neoplasm associated with high morbidity. We describe a case of embryonal rhabdomyosarcoma treated successfully with combination radiotherapy and chemotherapy.

A case of granulocytic sarcoma (chloroma) of the palatal mucosa is reported. Granulocytic sarcomas are composed of a localized collection of immature myeloid cells and are considered to be specific lesions of AML or the onset of a blast crisis in chronic myelogenous leukemia (CML). Localization in the oral cavity is rare. A review of the literature showed only thirty-six cases of granulocytic sarcoma in the oral cavity. In this paper we present patient’s data and an overview of the literature.

A case of squamous cell carcinoma of the base of tongue presenting initially as a cystic metastasis in the contralateral neck is described. The patient complained of a painless mass in the left neck, which was removed and histologically diagnosed as cystic malignancy. One year and seven months after the removal, a squamous cell carcinoma of the right tongue base and cystic metastases of the right neck were discovered. The histologic similarity among these three lesions strongly indicated the cystic metastases in the bilateral neck were from the squamous cell carcinoma of the tongue base.

Oral metastatic tumours are rare, and the main site affected is the mandible, with only few reports in the soft tissues. We are reporting a case of non-small cell undifferentiated carcinoma of the lung in a 52-year-old man, which developed metastasis to the vertebra, adrenal and upper vestibular gingiva. Clinically, the oral lesion mimicked a pyogenic granuloma. The biopsy established the gingival metastasis from lung cancer and after two weeks the patient died. This article showed a rare case of metastatic lung carcinoma to the gingiva and emphasized the differential diagnosis between proliferative lesions and metastatic tumours.