Pharmacological Research - Modern Chinese Medicine最新文献

{"title":"Therapeutic potential of a combination of Nigella sativa, Momordica charantia, and Anethum graveolens in metabolic syndrome management: An in vivo study","authors":"Rajashekar S. Chavan ,&nbsp;Nayeem A. Khatib ,&nbsp;Vishal S. Patil ,&nbsp;Jagadeesh Dodakallanavar","doi":"10.1016/j.prmcm.2025.100716","DOIUrl":"10.1016/j.prmcm.2025.100716","url":null,"abstract":"<div><h3>Background</h3><div>Metabolic syndrome (MetS) is a multifactorial disorder characterized by abdominal obesity, insulin resistance (IR), hypertension, dyslipidemia, and an increased risk of type 2 diabetes mellitus (T2DM) and cardiovascular diseases (CVDs). Conventional pharmacological interventions primarily manage symptoms but are associated with adverse effects. Bioactive compounds from medicinal plants offer promising multi-targeted therapeutic benefits. This study evaluates the efficacy of a polyherbal formulation containing extracts of <em>Nigella sativa</em> (NS, seed), <em>Momordica charantia</em> (MC, fruit), and <em>Anethum graveolens</em> (AG, fruit) in mitigating MetS-induced complications in an olanzapine (Zyprexa)-induced MetS rat model.</div></div><div><h3>Methods</h3><div>Animals were divided into five groups: normal control (saline), disease control (olanzapine (Zyprexa) 2 mg/kg, i.p., twice daily), and three treatment groups receiving olanzapine (Zyprexa) with formulations containing combination of NS, MC, and AG at 200 mg/kg (100:50:50), 400 mg/kg (200:100:100), and 800 mg/kg (400:200:200) orally. The study assessed metabolic parameters, including blood glucose levels, body weight, food and water intake, lipid profile, and Hemoglobin A1c/ glycated hemoglobin (HbA1c) levels. Cardiac activity function was evaluated using electrocardiography (ECG). Antioxidant status was assessed by estimating superoxide dismutase (SOD), catalase (CAT), and reduced glutathione (GSH) levels in tissue homogenates of the heart, liver, and pancreas. Histopathological examinations of these organs were also performed.</div></div><div><h3>Results</h3><div>Polyherbal formulation 800 mg/kg (400:200:200 ratio) significantly reduced blood glucose levels, improved lipid profiles, and mitigated weight gain induced by olanzapine (Zyprexa). ECG analysis demonstrated cardioprotective effects. Antioxidant enzyme activity, including SOD, CAT, and GSH levels, was notably improved in tissue homogenates. Histopathological evaluation further confirmed the protective effects on the liver, heart, and pancreas.</div></div><div><h3>Conclusion</h3><div>The findings suggest that the polyherbal formulation exerts protective effects against MetS by ameliorating blood glucose levels, improving lipid profile, enhancing antioxidant status, and preserving tissue architecture, thereby highlighting its potential as a natural therapeutic alternative for the management of metabolic syndrome.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"17 ","pages":"Article 100716"},"PeriodicalIF":0.0,"publicationDate":"2025-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145528411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discovery of antioxidant peptides from Humulus scandens by multi-step virtual screening, molecular docking, ligand efficiency analysis, and molecular dynamics simulation","authors":"Shi Qi Xu ,&nbsp;Wenchao Gong ,&nbsp;Wenjie Qin ,&nbsp;Dong-Hwa Chung ,&nbsp;De Xin Dang","doi":"10.1016/j.prmcm.2025.100715","DOIUrl":"10.1016/j.prmcm.2025.100715","url":null,"abstract":"<div><h3>Background</h3><div>Reactive oxygen species (ROS) are generated under both physiological and pathological conditions, including strenuous exercise, inflammation, and unhealthy dietary intake. Excessive ROS accumulation induces oxidative stress, which damages cellular components and contributes to the onset and progression of chronic diseases. Efficient elimination of ROS is therefore essential for maintaining redox homeostasis and promoting health. Antioxidant peptides derived from herbal medicines have recently gained increasing attention due to their natural origin, safety, and multifunctional biological activities. Compared with synthetic antioxidants, which may raise safety concerns with long-term use, these bioactive peptides represent a promising alternative.</div></div><div><h3>Purpose</h3><div>This study aimed to investigate Humulus scandens (HS), a traditional herbal medicine with reported antioxidant capacity, as a potential source of novel antioxidant peptides.</div></div><div><h3>Methods</h3><div>A systematic in silico workflow was applied, integrating virtual screening, molecular docking, ligand efficiency analysis, and molecular dynamics simulations. Keap1, a critical regulator of oxidative stress signaling, was selected as the molecular target.</div></div><div><h3>Results</h3><div>Seven candidate peptides were identified based on predicted non-toxicity, bioactivity, and favorable intestinal absorption. Among these, the tripeptide PGW demonstrated the greatest potential. Molecular docking revealed that PGW interacts with Keap1 through 10 hydrogen bonds, 1 hydrophobic interaction, and 22 van der Waals forces. Subsequent molecular dynamics simulations confirmed the stability of the PGW-Keap1 complex and supported its strong binding affinity.</div></div><div><h3>Conclusions</h3><div>The tripeptide PGW, derived from HS protein, exhibits promising antioxidant potential through direct interaction with Keap1. These findings highlight PGW as a candidate for development into functional food ingredients or nutraceuticals aimed at preventing oxidative stress-related disorders.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"17 ","pages":"Article 100715"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145528540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Crithmum maritimum: Phytoconstituents composition, and potential anticancer activity in gastrointestinal cancer mechanisms and prospects","authors":"Sourav Pal ,&nbsp;Arghya Panda ,&nbsp;Biprojit Bhowmick ,&nbsp;Khokan Bera","doi":"10.1016/j.prmcm.2025.100714","DOIUrl":"10.1016/j.prmcm.2025.100714","url":null,"abstract":"<div><h3>Introduction</h3><div><em>Crithmum maritimum</em>(sea fennel, Chinese: 海茴香 [hǎi huí xiāng]) is an edible halophyte traditionally valued in both Mediterranean diets and Traditional Chinese Medicine (TCM), where it is prescribed for “dissolving masses,” regulating qi, and resolving damp-heat/toxins—concepts aligned with anti-inflammatory, antimicrobial, and anticancer effects. Rich in phenolic acids, flavonoids, essential oils, fatty acids, vitamins, and minerals, it shows potential against gastrointestinal tract (GIT) cancers, a growing global health burden.</div></div><div><h3>Methods</h3><div>A systematic literature search was conducted in PubMed, Scopus, Web of Science, and Google Scholar for studies published between 2010 and 2025, limited to English language studies, using keywords “Crithmum maritimum,” “sea fennel,” “gastrointestinal cancer,” “anticancer,” “polyphenols,” “essential oils,” and “bioactive compounds.” of 167 retrieved records, 138 met the inclusion criteria: original in vitro, in vivo, or clinical research evaluating <em>C. maritimum</em> or its constituents for anticancer activity in GIT malignancies. Exclusion criteria removed reviews without new data, unrelated species, and studies lacking mechanistic outcomes.</div></div><div><h3>Results</h3><div><em>C. maritimum</em> exhibits preclinical efficacy against GIT cancers via modulation of p53, NRF2, and Wnt/β-catenin pathways, aligning with its traditional TCM uses. Studies identified chlorogenic acid (30–50 % of total polyphenol), gallic acid (15–20 % of terpene), limonene, sabinene, α-pinene, γ-terpinene, fatty acids, and vitamin C as key anticancer agents that promote apoptosis, inhibit angiogenesis, and attenuate oxidative and inflammatory signaling in GIT cancer models.</div></div><div><h3>Conclusion</h3><div><em>C. maritimum</em> exhibits a broad phytochemical spectrum with multitargeted preclinical efficacy against GIT cancers, consistent with its historical TCM applications. Standardization, mechanistic validation, and clinical trials are required to advance its therapeutic integration.</div></div><div><h3>Significance Statement</h3><div>This review unites TCM tradition with modern biomedical evidence, highlighting <em>C. maritimum</em> as a promising natural agent for GIT cancer prevention and management, with mechanistic breadth well-suited to the multifactorial nature of these malignancies.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"17 ","pages":"Article 100714"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145466300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Honokiol as a next-generation phytotherapeutic: Anticancer, neuroprotective, and nanomedicine perspectives","authors":"Dilpreet Singh ,&nbsp;Nandni ,&nbsp;Neena Bedi","doi":"10.1016/j.prmcm.2025.100713","DOIUrl":"10.1016/j.prmcm.2025.100713","url":null,"abstract":"<div><h3>Introduction</h3><div>Honokiol (<strong>厚朴酚, Hou Po Fen</strong>), a biphenolic compound derived from the bark of <em>Magnolia officinalis</em> (<strong>厚朴, Hou Po</strong>), has emerged as a promising phytochemical with multi-target pharmacological activities. Traditionally used in East Asian medicine, it is now being investigated for applications in cancer, neurodegenerative disorders, inflammation, and infectious diseases. Its therapeutic promise is attributed to its ability to modulate critical signaling pathways including NF-κB, STAT3, PI3K/Akt/mTOR, and Nrf2.</div></div><div><h3>Methods</h3><div>This review synthesizes and critically analyzes published evidence on honokiol’s chemical properties, mechanisms of action, pharmacological activities, and nanotechnology-based delivery systems. Literature was sourced from PubMed, Scopus, and Web of Science databases, focusing on preclinical, clinical, and formulation studies of honokiol between 2000–2025. Key molecular targets, in vitro and in vivo efficacy, and translational challenges were evaluated and summarized.</div></div><div><h3>Results</h3><div>Honokiol demonstrates potent antioxidant, anti-inflammatory, anticancer, antimicrobial, and neuroprotective activities. It effectively induces apoptosis, inhibits angiogenesis, and modulates tumor microenvironmental factors. Neuroprotective actions include attenuation of neuroinflammation, preservation of mitochondrial function, and improvement of cognitive performance. Nanocarrier-based systems—such as liposomes, polymeric nanoparticles, micelles, and nanoemulsions—significantly improve honokiol’s solubility, stability, and bioavailability. Preclinical data confirm efficacy across cancer, neurological, and inflammatory models, though clinical evidence remains limited.</div></div><div><h3>Discussion</h3><div>Honokiol represents a promising next-generation phytotherapeutic candidate bridging traditional Chinese medicine and modern molecular pharmacology. Despite strong preclinical support, translational progress is hindered by low water solubility, poor bioavailability, limited clinical trials, and regulatory challenges. Advances in nanotechnology, epigenetic modulation, and personalized medicine approaches may accelerate clinical adoption. Future research should focus on standardized formulations, biomarker-driven trials, and integration with emerging therapeutic technologies.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"17 ","pages":"Article 100713"},"PeriodicalIF":0.0,"publicationDate":"2025-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145466289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated network, docking, and experimental validation of the dual anti-inflammatory and uricosuric actions of Artemisia vulgaris compounds","authors":"Pham Thi Nhat Trinh ,&nbsp;Dang Thi Le Hang ,&nbsp;Nguyen Ngoc Phuong Uyen ,&nbsp;Tran Nguyen Minh An ,&nbsp;Le Xuan Tien ,&nbsp;Le Tien Dung","doi":"10.1016/j.prmcm.2025.100712","DOIUrl":"10.1016/j.prmcm.2025.100712","url":null,"abstract":"<div><div>In Traditional Chinese Medicine (TCM), mugwort (<em>Artemisia vulgaris</em>) is documented as the primary material for moxibustion, prepared as moxa floss (<em>ai rong</em>, 艾绒), moxa cones (<em>ai zhu</em>, 艾炷), and moxa sticks (<em>ai tiao</em>, 艾条) to warm the channels and regulate qi–blood [6–8]. We therefore investigated <em>A. vulgaris</em> compounds for multi-target anti-gout relevance, anchored in these TCM indications.</div><div>Network pharmacology and molecular docking prioritized A. vulgaris phytochemicals against gout-related targets, followed by in-vitro validation in LPS-challenged RAW 264.7 macrophages.</div><div>Of 62 compounds, 52 met drug-likeness and intersected 277 gout genes. A flavonoid (AV52) showed strong predicted binding to PTGS2/XO, and artemisinin (AV46) to urate transporters (SLC22A12/ABCG2). Experimentally, AV46 reduced IL-6/TNF-α and nitrite while preserving IL-10. IL-10 showed a small, non-monotonic change at 6.25 µM (<em>p</em> &lt; 0.05) that was not reproduced at adjacent doses, suggesting limited biological relevance, while overall IL-10 was preserved alongside reductions in IL-6 and TNF-α.</div><div>Framed within TCM practice of moxibustion and warming/qi–blood-regulating indications, these data support a lead–anchor concept (AV52 anti-inflammatory/XO; AV46 uricosuric-anti-inflammatory) warranting further in-vivo and formulation studies for TCM-relevant applications.</div><div>A. vulgaris phytochemicals demonstrate complementary potential against gout-related inflammation and urate handling within a TCM use-case anchored to mugwort preparations (moxa floss/cones/sticks). AV46 showed experimental activity consistent with predictions, while AV52 requires bench confirmation. These results motivate focused biochemical, transporter, pharmacokinetic, and in-vivo evaluations to support translation into Chinese preparation - compatible applications.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"17 ","pages":"Article 100712"},"PeriodicalIF":0.0,"publicationDate":"2025-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145417214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanistic insights into the neuroprotective effects of Radix Astragali (Huang Qi): Bridging Traditional Chinese Medicine and modern pharmacology","authors":"Rizwan Ahmad ,&nbsp;Chhavi Verma ,&nbsp;Sandeep Kumar ,&nbsp;Vishal Kumar ,&nbsp;Darakhshan Gazala Bari ,&nbsp;Saurabh Sharma ,&nbsp;Shadab Ali ,&nbsp;Shamim Shamim","doi":"10.1016/j.prmcm.2025.100711","DOIUrl":"10.1016/j.prmcm.2025.100711","url":null,"abstract":"<div><h3>Introduction</h3><div><em>Radix Astragali</em>, a major herb in Traditional Chinese Medicine, has traditionally been used to strengthen vital energy and promote blood circulation. Recent research has revealed its neuroprotective potential in disorders such as ischemic stroke, Alzheimer’s disease, and traumatic brain injury.</div></div><div><h3>Methods</h3><div>This review evaluates recent preclinical and clinical studies on the neuroprotective effects of <em>Radix Astragali</em> and its active components, including astragaloside four, flavonoids, polysaccharides, terpenoids, alkaloids, and amino acids. Peer-reviewed scientific literature was analyzed and interpreted within the context of Traditional Chinese Medicine principles.</div></div><div><h3>Results</h3><div><em>Radix Astragali</em> exhibits multiple neuroprotective actions, including antioxidant, anti-inflammatory, anti-apoptotic, and immune-regulating effects. Astragaloside IV regulates critical signaling pathways, including phosphoinositide 3-kinase/protein kinase B, mitogen-activated protein kinase, and nuclear factor-κB, thereby supporting neuronal survival and reducing oxidative damage. Flavonoids and polysaccharides enhance synaptic plasticity, nerve regeneration, and cerebral blood flow. These findings are consistent with Traditional Chinese Medicine concepts of replenishing vital energy and stimulating blood flow in neurological disorders.</div></div><div><h3>Discussion</h3><div><em>Radix Astragali</em> exemplifies the integration of Traditional Chinese Medicine and modern neuropharmacology. However, clinical translation remains limited due to challenges in standardization, potential herb drug interactions, and insufficient large-scale clinical validation. Future studies should emphasize pharmacokinetics, synergistic formulations, and biomarker-based personalized neurotherapy to ensure safe and effective clinical application.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"17 ","pages":"Article 100711"},"PeriodicalIF":0.0,"publicationDate":"2025-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145417334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic modulation of unfolded protein response by biochemic tissue salts in alcohol- and acetaminophen-induced liver cirrhosis","authors":"Debabrata Dash,&nbsp;Raj Kumar Koiri","doi":"10.1016/j.prmcm.2025.100710","DOIUrl":"10.1016/j.prmcm.2025.100710","url":null,"abstract":"<div><h3>Introduction</h3><div>Alcohol-associated liver disease (ALD) is a major global public health problem with chronic alcohol use responsible for a large proportion of alcohol-attributed fatalities. The combined exposure to acetaminophen raises the level of hepatotoxicity. The unfolded protein response (UPR) is one of the key cellular processes stimulated following liver injury but whose regulation under dual alcohol and acetaminophen treatment is ill defined. While Natrum sulphuricum (NS) and Natrum phosphoricum (NP) are Western biochemic homeopathic tissue salts, mineral salts and allied compounds have been traditionally used in Traditional Chinese Medicine (TCM) for the upkeep of liver and digestive functions. The present study was aimed at ascertaining hepatoprotective action of NS and NP through modulation of UPR signaling in chemically induced liver cirrhosis rat model.</div></div><div><h3>Methods: Wistar albino rats were divided at random into five groups</h3><div>control, alcohol control, liver cirrhosis, LC+NS, and LC+NP. Liver cirrhosis was induced by chronic oral treatment with alcohol and acetaminophen. NS and NP were given orally for four weeks following induction. Liver tissues were taken for molecular analysis, and expression of a few of the major UPR-related genes and proteins were quantified by quantitative RT-PCR and Western blotting.</div></div><div><h3>Results</h3><div>Both acetaminophen and alcohol coexposures significantly dysregulated UPR markers, suggesting endoplasmic reticulum stress and altered proteostasis. NP and NS treatment restored levels of key UPR components, suggesting therapeutic protein-folding mechanism modulation.</div></div><div><h3>Conclusions</h3><div>NS and NP showed hepatoprotective action through UPR signaling modulation and reduction of protein-misfolding stress in chemically induced liver cirrhosis. These results are preliminary scientific basis to explore mineral-based compounds in new and traditional medicine settings, including their theoretical significance to TCM approaches to the prevention of liver disease.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"17 ","pages":"Article 100710"},"PeriodicalIF":0.0,"publicationDate":"2025-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145363238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"To explore the scientific connotation of Fuyang therapy for liver cancer based on mitochondrial function","authors":"Yang Wang ,&nbsp;Bugao Zhou ,&nbsp;Shanshan Li ,&nbsp;Linxin Zheng ,&nbsp;Bohan Cai ,&nbsp;Huiyu Wang ,&nbsp;Sili Li ,&nbsp;Yuhan Lin ,&nbsp;Yanhe Xu","doi":"10.1016/j.prmcm.2025.100709","DOIUrl":"10.1016/j.prmcm.2025.100709","url":null,"abstract":"<div><h3>Background</h3><div>Liver cancer poses a serious threat to human health,and research into its pathogenesis and exploration of treatment strategies have always been major focuses in the medical field.Recent studies have indicated that mitochondrial dysfunction plays a promoting role in the progression of liver cancer,primarily manifested through disruptions in energy metabolism,decreased mitochondrial outer membrane permeability, and dysregulation of calcium ion homeostasis. In traditional Chinese medicine (TCM), “Yang deficiency and Yin excess” is considered the core pathogenesis of liver cancer, and the fundamental treatment principle of “Fuyang Guben” (supporting Yang and reinforcing the root) has been proposed. The mechanism of action may be associated with the improvement of mitochondrial function, however modern research in this area remains relatively limited.</div></div><div><h3>Methods</h3><div>Through theoretical analysis and comprehensive literature review, this paper elucidates the theoretical basis of Fuyang therapy for liver cancer from the perspective of TCM theory,summarizes the specific roles of mitochondrial function in the progression of liver cancer, and systematically reviews recent advances in modern mechanistic research on how Fuyang therapy inhibits the occurrence and development of liver cancer by regulating mitochondrial function.</div></div><div><h3>Results</h3><div>Fuyang therapy can improve mitochondrial function from multiple perspectives,including restoring energy metabolism,regulating membrane permeability, and maintaining calcium homeostasis,thereby inhibiting the proliferation and progression of liver cancer cells.Existing experimental and clinical studies have preliminarily verified the potential efficacy of Fuyang-based formulas in anti-liver cancer treatments and their regulatory mechanisms involving mitochondrial function-related pathways.</div></div><div><h3>Conclusion</h3><div>Fuyang therapy demonstrates both theoretical rationality and experimental support in the treatment of liver cancer.Its anti-liver cancer effects are achieved through the improvement of mitochondrial function,providing new insights for the formulation of TCM-based treatments and mechanistic research on liver cancer.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"17 ","pages":"Article 100709"},"PeriodicalIF":0.0,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145363236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of Traditional Chinese medicinal plants in the management of fibromyalgia: A review","authors":"Kaniga Pandi,&nbsp;Binoy Varghese Cheriyan,&nbsp;Kunal R. Kataria","doi":"10.1016/j.prmcm.2025.100707","DOIUrl":"10.1016/j.prmcm.2025.100707","url":null,"abstract":"<div><h3>Introduction</h3><div>Fibromyalgia is a chronic, multifactorial disorder characterized by widespread musculoskeletal pain, fatigue, sleep disturbances, and cognitive impairments, substantially reducing quality of life. Conventional pharmacological therapies, including analgesics, antidepressants, and anticonvulsants, provide only partial relief and are often associated with adverse effects. This highlights the need for safer and more effective alternatives. Traditional Chinese Medicine (TCM) has a long history of managing chronic pain conditions through medicinal plants, which may offer therapeutic benefits in fibromyalgia.</div></div><div><h3>Methods</h3><div>A systematic literature search was performed across PubMed, Scopus, Web of Science, and CNKI databases using predetermined inclusion and exclusion criteria. The focus was on studies reporting the phytochemical composition, pharmacological actions, and clinical outcomes of TCM medicinal plants relevant to fibromyalgia.</div></div><div><h3>Results</h3><div>Several plants with potential therapeutic effects were identified, including <em>Panax ginseng</em> (Ren Shen), <em>Corydalis yanhusuo</em> (Yan Hu Suo), <em>Salvia miltiorrhiza</em> (Dan Shen), and <em>Astragalus membranaceus</em> (Huang Qi). Their bioactive compounds, ginsenosides, tetrahydropalmatine, salvianolic acids, ferulic acid, and astragalosides, exert multimodal actions. These include modulation of neurotransmitter pathways, reduction of pro-inflammatory cytokines, antioxidative activity, and improvement of mitochondrial function. Preclinical studies demonstrate analgesic, anti-fatigue, and neuroprotective effects, while limited clinical evidence suggests improvements in pain, sleep, and overall well-being.</div></div><div><h3>Discussion</h3><div>Although preliminary findings are promising, current evidence is limited by small sample sizes, heterogeneous herbal formulations, and lack of standardized dosing regimens. Well-designed, large-scale randomized controlled trials are essential to validate efficacy, establish safety profiles, and support the integration of TCM herbal therapies into evidence-based fibromyalgia management.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"17 ","pages":"Article 100707"},"PeriodicalIF":0.0,"publicationDate":"2025-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145417335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ameliorative effects of traditional Chinese medicine formula NRICM101 on periodontal inflammation: In vitro and in vivo","authors":"Fang-Wei Lin ,&nbsp;Yann-Jen Chen ,&nbsp;Hui-Rong Cheng ,&nbsp;Chi-Tsung Wu ,&nbsp;Hsien-Chung Chiu","doi":"10.1016/j.prmcm.2025.100708","DOIUrl":"10.1016/j.prmcm.2025.100708","url":null,"abstract":"<div><h3>Introduction</h3><div>Taiwan Chingguan Yihau (NRICM101) is a novel anti-inflammatory traditional Chinese medicine formula developed in 2020 for COVID-19 pandemic. This study aimed to evaluate the effect of NRICM101 on periodontal inflammation, using human gingival fibroblasts (HGFs) exposed to <em>Porphyromonas gingivalis</em> lipopolysaccharide (Pg LPS) and rat models of ligature-induced periodontitis.</div></div><div><h3>Methods</h3><div><em>In vitro</em>, HGFs were stimulated with Pg LPS and NRICM101. Cell viability and the expression of pro-inflammatory cytokines, including interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and IL-1β were measured using MTS assay and reverse transcription quantitative polymerase chain reaction (RT-qPCR). <em>In vivo</em>, Sprague-Dawley rats were divided into control, ligature placement, and NRICM101 treatment groups. Ligature placement was performed at day one and oral administration of NRICM101 (50 or 100 mg/kg body weight/day) or saline began one day prior to ligation and the following days. On day 8, the rats were sacrificed, periodontal tissue specimens were analyzed using microcomputed tomography (Micro-CT) imaging, RT-qPCR, and immunohistochemical (IHC) staining to evaluate the effects of the treatments.</div></div><div><h3>Results</h3><div>NRICM101 reduced HGFs viability above 1.0 mg/mL, while Pg LPS caused similar effects at concentrations above 1.0 μg/mL. Co-treatment with Pg LPS (0.5–1.0 μg /mL) and NRICM101 (0.1–0.5 mg/mL) showed no cytotoxicity. <em>In vivo</em>, NRICM101 attenuated alveolar bone loss and significantly decreased IL-6, TNF-α, and partially IL-1β expression, as confirmed by micro-CT, RT-qPCR, and IHC analyses.</div></div><div><h3>Discussion</h3><div>This study demonstrates that NRICM101 exerts protective anti-inflammatory effects in both cellular and animal models of periodontitis. It suppressed pro-inflammatory cytokine expression in HGFs and mitigated alveolar bone loss in ligature-induced periodontitis rats. The effects on IL-6 and TNF-α were pronounced, while the partial reduction of IL-1β may reflect additional regulatory mechanisms such as inflammasome activation, which warrants further investigation. These findings indicate that NRICM101 reduces inflammation without cytotoxicity and supports its potential application in managing chronic periodontal inflammation.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"17 ","pages":"Article 100708"},"PeriodicalIF":0.0,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145363239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}