Pharmacological Research - Modern Chinese Medicine最新文献

{"title":"Quail egg yolk oil attenuates insulin resistance and redox imbalance in a high-sugar-diet drosophila model","authors":"Muhammad Sani Ismaila ,&nbsp;Ismail Sulaiman ,&nbsp;Abdulbariu Ogirima Uhuami ,&nbsp;Venkatesan Sundaram ,&nbsp;Mustapha Umar Imam","doi":"10.1016/j.prmcm.2025.100740","DOIUrl":"10.1016/j.prmcm.2025.100740","url":null,"abstract":"<div><h3>Introduction</h3><div>Type 2 diabetes mellitus (T2DM) is increasing globally, creating a need for natural and functional food–based therapeutic interventions. Quail egg yolk oil (QEYO), traditionally used in Chinese medicine as 鹌鹑蛋黄油 (ānchún dànhuáng yóu) for nourishing Yin and supporting metabolic balance, contains bioactive lipids and antioxidants with potential relevance for glycemic and redox regulation. This study investigated the antidiabetic and antioxidant effects of QEYO in a high-sugar diet (HSD)–induced metabolic dysfunction model in <em>Drosophila melanogaster</em>.</div></div><div><h3>Methods</h3><div>Adult male <em>Drosophila melanogaster</em> were fed a high-sugar diet (30% sucrose) to induce metabolic dysfunction and allocated into five groups: control, HSD, QEYO (62.5 or 125 mg/10 mL diet), and metformin (16 mg/10 mL). After 14 days of HSD induction followed by 7 days of treatment, physiological parameters, glucose and lipid biomarkers, oxidative stress indicators, and expression of key metabolic genes were assessed using enzymatic assays and RT-qPCR.</div></div><div><h3>Results</h3><div>HSD-fed flies developed obesity, hyperglycemia, elevated triglycerides, oxidative stress, and dysregulation of insulin pathway–related genes. QEYO significantly ameliorated these abnormalities in a dose-dependent manner. The 62.5 mg dose produced stronger glucose-lowering effects, while the 125 mg dose showed greater antioxidant enhancement and improved expression of SOD, CAT, IRS, and DILP2. Metformin produced comparable metabolic benefits.</div></div><div><h3>Discussion</h3><div>QEYO improved glucose homeostasis, lipid metabolism, and insulin pathway activity, and reduced markers of insulin resistance and oxidative imbalance in HSD-induced flies. These findings support its potential as a functional food–based intervention for T2DM and correspond with its traditional role in Chinese dietary therapy for metabolic regulation. Further mammalian studies are required for translational confirmation.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"18 ","pages":"Article 100740"},"PeriodicalIF":0.0,"publicationDate":"2025-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145750151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aganope thyrsiflora (Benth.) Polhill: Acute, sub-acute, and in silico toxicological evaluation of an underexplored ethnomedicinal plant","authors":"Lalnun Hruaitluangi ,&nbsp;Lalduhawma Chhakchhuak ,&nbsp;Anima Debbarma ,&nbsp;C. Malsawmtluangi ,&nbsp;Hauzel Lalhlenmawia ,&nbsp;Ajmal Koya Pulikkal ,&nbsp;Lalzikpuii Sailo","doi":"10.1016/j.prmcm.2025.100735","DOIUrl":"10.1016/j.prmcm.2025.100735","url":null,"abstract":"<div><h3>Ethnopharmacological relevance</h3><div><em>Aganope thyrsiflora</em> (Benth.) Polhill, is a lesser-known ethnomedicinal plant traditionally used to treat gastrointestinal ailments. Despite its use in folk medicine, its pharmacological efficacy and safety profile remain largely unexamined.</div></div><div><h3>Aim of the study</h3><div>To evaluate the systemic effects and potential toxicological risks of the methanolic extract of <em>A. thyrsiflora</em> through combined experimental and computational approaches.</div></div><div><h3>Materials and methods</h3><div><em>In vivo</em> acute and sub-acute toxicity were assessed via biochemical analysis, liver histopathology, and serum electrolyte analysis. LC-MS identified major phytoconstituents, which were further evaluated using <em>in silico</em> toxicity prediction tools.</div></div><div><h3>Results</h3><div>Extract treatment increased serum cholesterol, triglycerides, and very low-density lipoproteins (VLDL), while reducing low-density lipoprotein (LDL) levels. Liver function markers remained within physiological ranges, though serum alkaline phosphatase (SAP) increased at higher doses. Histopathology confirmed preserved hepatic structure without pathological changes. A remarkable hypoglycemic effect were observed. LC-MS identified fifteen major compounds, several of which were flagged with organ-specific toxicity alerts <em>in silico</em>.</div></div><div><h3>Conclusion</h3><div>The methanolic extract of <em>A. thyrsiflora</em> shows hypoglycemic potential and general hepatic safety at tested doses. However, its metabolic effects and predicted compound-specific toxicities highlight the need for further investigation. This study provides the first toxicological basis for future pharmacological validation of this underexplored ethnomedicinal species.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"18 ","pages":"Article 100735"},"PeriodicalIF":0.0,"publicationDate":"2025-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145799891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vivo, in vitro, and in silico evaluation of the analgesic, antidiarrheal, and anthelmintic activities of methanolic extract of Syzygium grande (Wight) Walp","authors":"Md. Jahirul Islam Mamun,&nbsp;Md. Hossain Rasel,&nbsp;Zobayed Islam,&nbsp;Khurshida Jahan Suma,&nbsp;Mohi Uddin","doi":"10.1016/j.prmcm.2025.100734","DOIUrl":"10.1016/j.prmcm.2025.100734","url":null,"abstract":"<div><h3>Background</h3><div><em>Syzygium grande</em> (syn. Eugenia grandis), commonly known as the sea apple, is a medicinally important plant that has been traditionally used to treat various ailments, including coughs, hemorrhoids (piles), dental problems, dysentery, bronchitis, and diabetes. This study aimed to evaluate the <em>in vitro</em> anthelmintic, <em>in vivo</em> analgesic, and antidiarrheal activities of the methanolic extract of <em>S. grande</em> (MESG) using Swiss albino mice.</div></div><div><h3>Methods</h3><div>The anthelmintic activity was tested on the earthworm <em>Pheretima posthuma</em>. At the same time, analgesic effects were assessed using three models: the acetic acid-induced writhing test, the formalin-induced paw licking test, and the hot plate test. Antidiarrheal activity was evaluated using castor oil-induced diarrhea and the gastrointestinal motility test with charcoal meal. To support experimental findings, in silico methods such as molecular docking, ADME/T, PASS prediction, and network pharmacology were employed.</div></div><div><h3>Results</h3><div>Significant writhing inhibition was shown by MESG at 400 mg/kg—66.82% in the acetic acid test and 63.38% in the formalin test (p &lt; 0.001), and showed marked analgesic activity in the hot plate test. At 200 mg/kg, the extract also exhibited strong antidiarrheal effects (p &lt; 0.001). In the anthelmintic test, MESG at 10 μg/mL showed maximum efficacy comparable to levamisole (10 μg/mL). To clarify the multi-target potential of <em>S. grande</em> phytochemicals in modifying key proteins involved in pharmacological processes, this study combines network pharmacology with molecular docking. Molecular docking results revealed that gamma-sitosterol exhibited the highest binding affinity against 6COX, 5ZHP, and 1SA0 protein targets, suggesting strong potential as a drug candidate due to its favorable interactions.</div></div><div><h3>Conclusion</h3><div>Based on both experimental and computational evidence, MESG shows promise as a potential source of natural analgesic, antidiarrheal, and anthelmintic agents, warranting further research for drug development.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"18 ","pages":"Article 100734"},"PeriodicalIF":0.0,"publicationDate":"2025-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145750172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The anti-tumor effect of chinese medicine extracts camptothecin -AS1411 system","authors":"Zhanbiao He ,&nbsp;Zhen Wang ,&nbsp;Lu Ga ,&nbsp;Jun Ai ,&nbsp;Xin Tong","doi":"10.1016/j.prmcm.2025.100732","DOIUrl":"10.1016/j.prmcm.2025.100732","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Introduction&lt;/h3&gt;&lt;div&gt;The AS1411 aptamer has shown great potential in the development of targeted anti-tumor drug delivery systems. &lt;strong&gt;Camptothecin (CPT, Xǐshù Jiǎn)&lt;/strong&gt;, a cytotoxic quinoline alkaloid first isolated from the traditional Chinese medicine &lt;em&gt;Camptotheca acuminata&lt;/em&gt; (Xǐshù), has been extensively used in various Chinese medicinal preparations including Xi Shu Injection and compound formulations combined with other herbs for cancer treatment. Despite its potent antitumor activity demonstrated in both traditional applications and modern clinical studies, the clinical application of CPT is limited by poor water solubility, low stability, and lack of tumor selectivity. Although some studies have combined AS1411 with chemotherapeutic drugs, the precise binding mechanism between the AS1411 G-quadruplex and small molecule drugs like CPT remains unclear. A systematic investigation into their interaction is crucial for the rational design of efficient and targeted drug delivery systems that can enhance the therapeutic potential of this important TCM-derived compound.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;In this work, we first synthesized a CPT-AS1411 complex and confirmed its formation. Subsequently, we employed a suite of biophysical techniques to decipher the binding mechanism between CPT and the AS1411 G-quadruplex. UV–Vis absorption and steady-state fluorescence spectroscopy were used to verify complex formation and determine the quenching constant. Ethidium bromide (EtBr) displacement assays were conducted to probe the binding mode (e.g., intercalation or groove binding). Circular dichroism (CD) spectroscopy was utilized to monitor conformational changes in the AS1411 structure upon CPT binding. Furthermore, the effects of ionic strength and the stability of the complex under different storage conditions were evaluated.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;UV–Vis and fluorescence spectroscopy confirmed the formation of the CPT-AS1411 complex. The calculated quenching constant (K∼SV∼ = 0.5135 M⁻¹, K∼q∼ = 5.135 × 10⁷ M⁻¹·S⁻¹) indicated a static quenching process, suggesting the formation of a ground-state complex. EtBr displacement studies and CD spectral analysis collectively demonstrated a non-intercalative binding mode between CPT and AS1411. Investigations into ionic strength revealed that electrostatic interactions played a minor role in complex formation. Stability studies indicated that the CPT-AS1411 complex was more stable when stored at -4 °C compared to room temperature.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;This study comprehensively elucidates the non-intercalative binding mechanism between CPT and the AS1411 G-quadruplex through multi-spectroscopic methods. Our findings provide crucial molecular-level insights and a solid experimental foundation for the future development of AS1411-based targeted delivery systems for camptothecin and its derivatives, potentially enhancing their therapeutic efficacy a","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"18 ","pages":"Article 100732"},"PeriodicalIF":0.0,"publicationDate":"2025-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145694951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Network pharmacology-integrated molecular docking and experimental validation: Unveiling the protective mechanism of sanhuang guben zhike formula in chronic obstructive pulmonary disease","authors":"Hongyan Lin ,&nbsp;Chaofan Pang ,&nbsp;Mengmeng Liu ,&nbsp;Yiwei Huang ,&nbsp;Xinru Xia ,&nbsp;Yaqi Xu ,&nbsp;Wenxue Sun ,&nbsp;Hongxia Zhang","doi":"10.1016/j.prmcm.2025.100733","DOIUrl":"10.1016/j.prmcm.2025.100733","url":null,"abstract":"<div><h3>Introduction</h3><div><em>SanHuang Guben Zhike Formula</em> (SHGBZKF) is a classical herbal prescription for pulmonary diseases, but its material basis and mechanisms in chronic obstructive pulmonary disease (COPD) are poorly understood. This study investigated its active ingredients and therapeutic mechanisms in COPD via network pharmacology, molecular docking, kinetic simulation, and in vitro experiments.</div></div><div><h3>Methods</h3><div>Active ingredients of SHGBZKF were screened using TCMSP and SwissADME. COPD-related targets were retrieved from DisGeNET and others, with overlapping targets identified. Core targets were screened via Cytoscape-constructed PPI networks; GO/KEGG analyses used Metascape. Ligand-receptor binding was evaluated by AutoDock Vina 1.1.2, and complex stability verified via GROMACS. β-sitosterol’s effects were validated in CSE-induced COPD cells.</div></div><div><h3>Results</h3><div>A total of 120 active ingredients and 208 common targets with COPD were identified, including core targets STAT3, AKT1, EGFR. KEGG showed activated PI3K-AKT and EGFR pathways. β-sitosterol had optimal binding energies with AKT1 (ΔG=-10.8 kcal/mol) and EGFR (ΔG= -9.7 kcal/mol), with stable complexes confirmed. It inhibited EGFR, AKT, MAPK pathways, exerting therapeutic effects in CSE-induced cells.</div></div><div><h3>Discussion</h3><div>SHGBZKF may alleviate COPD progression by synergistically regulating EGFR, AKT, and MAPK signaling pathways through components such as β-sitosterol. Our research first uncovered the molecular mechanism underlying the therapeutic effect of SHGBZKF on respiratory diseases, and this finding is anticipated to lay a theoretical foundation for the clinical use of SHGBZKF.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"18 ","pages":"Article 100733"},"PeriodicalIF":0.0,"publicationDate":"2025-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145694953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chinese herbal medicine Quxie formula inhibits colon cancer liver metastasis through modulating gut Actinobacteria induced apoptosis and anti-cancer immunity","authors":"Yunzi Yan ,&nbsp;Bo Feng ,&nbsp;Jake Mao ,&nbsp;Chunhui Ning ,&nbsp;Yufei Yang ,&nbsp;Lingyun Sun","doi":"10.1016/j.prmcm.2025.100724","DOIUrl":"10.1016/j.prmcm.2025.100724","url":null,"abstract":"<div><h3>Objective</h3><div>Liver metastasis is the leading cause of mortality in colon cancer patients. Traditional Chinese herbal medicine Quxie formula (QX) has been shown to prolong survival, improve immune function and modulate the gut microbiome, particularly increasing <em>Actinobacteria</em> in metastatic colorectal cancer (mCRC) patients. However, the mechanism remains unclear.</div></div><div><h3>Methods</h3><div><em>In Vitro</em>, QX-containing serum was extracted from rats and used to culture three <em>Actinobacteria</em> strains: <em>Bifidobacterium adolescentis (B. a.), Streptomyces carpaticus</em>, and <em>Bacillus</em>. After screening for bacterial growth, QX-<em>B. a.</em> co-culture products were applied to HCT-116 cells to assess apoptosis and apoptosis-related protein expression. Caspase3, Caspase8, and Caspase9 pathways were blocked to further investigate apoptosis mechanisms. We then established a CT-26 liver metastasis mouse model pretreated with cocktail antibiotics, followed by 14-day QX decoction treatment. Liver tissue, immune function, cytokine, and gut microbiome were analyzed using Western blotting (WB), flow cytometry analysis, ELISA and 16S rRNA sequencing, respectively.</div></div><div><h3>Results</h3><div><em>In Vitro</em>, QX-containing serum significantly promoted <em>B. a.</em> proliferation, and the QX-<em>B. a.</em> co-culture products induced higher apoptosis rates in HCT-116 cells than controls. WB results showed increased expression of Caspase3, Caspase8, Caspase9, Bax, and Bid, and decreased Bcl-2 expression in QX-<em>B. a.</em> co-culture groups. Blocking Caspase3, Caspase8, and Caspase9 significantly reduced apoptosis, confirming the Bcl-2/Bax pathway’s involvement. <em>In Vivo</em>, 10 mg, 15 mg, and 20 mg daily QX treatment significantly reduced liver metastasis tumor burden. QX treatment increased gut <em>Actinobacteria, Bacteroidet</em>es, and <em>Firmicutes</em> abundance compared to model groups. QX significantly enhanced the protein expression of Caspase3, Caspase8 and Caspase9 in liver metastatic tissues. Compared to model group, QX could significantly enhance the proportion of CD8+, expression of TNF-α and IFN-γ in peripheral blood. In liver metastatic tissue, QX could restore the NK cells’ ability of targeting and killing cancer cells. Through UPLC-Q-TOF-MSE analysis, 69 molecular compounds were preliminarily identified in the decoction of QX and medicated serum.</div></div><div><h3>Conclusion</h3><div>This study provides new insights into the gut microbiome-mediated anti-cancer effects of QX, warranting further investigation into its active components and therapeutic mechanism.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"17 ","pages":"Article 100724"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145623890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction notice to “Inhibition of oxido-inflammatory and apoptotic pathway is involved in the protective effect of Ginkgo biloba supplement in cyclosporine-A induced vascular dysfunction in Wistar rat” [Pharmacological Research – Modern Chinese Medicine 7 (2023) 100252]","authors":"Jerome Ndudi Asiwe ,&nbsp;Simon Irikefe Ovuakporaye ,&nbsp;Benneth Ben-Azu ,&nbsp;Jamil Usman Dauda ,&nbsp;Vincent-Junior Onoriode Igben ,&nbsp;Endurance Efe Ahama ,&nbsp;Ehizokhale Santos Ehebha ,&nbsp;Vincent Ugochukwu Igbokwe","doi":"10.1016/j.prmcm.2025.100704","DOIUrl":"10.1016/j.prmcm.2025.100704","url":null,"abstract":"","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"17 ","pages":"Article 100704"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145736395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical composition and pharmacological activities of centranthera grandiflora benth.: A brief review","authors":"Sina Cun,&nbsp;Xin Li,&nbsp;Zhenjuan Duan,&nbsp;Kezhen Qi,&nbsp;Xiaoyun Pu","doi":"10.1016/j.prmcm.2025.100727","DOIUrl":"10.1016/j.prmcm.2025.100727","url":null,"abstract":"<div><h3>Introduction</h3><div><em>Centranthera grandiflora</em> Benth. (<em>C. grandiflora</em> Benth.) (大花胡麻草) is an important medicinal plant with edible varieties. It is widely used as a folk Chinese medicine in Honghe Prefecture, Yunnan Province, known for its effects in reducing swelling, dissipating stasis, promoting blood circulation, and alleviating pain. It is often used to treat injuries, high fever in children and irregular menstruation.</div></div><div><h3>Aim of the review</h3><div>This paper reviews the research progress on the chemical constituents and pharmacological effects of <em>C. grandiflora</em> Benth. to provide a basis for further research and development of its medicinal value.</div></div><div><h3>Methods</h3><div>The relevant reports of chemical composition and pharmacological effects of <em>C. grandiflora</em> Benth. were collected from various academic databases and search engines, including Google Scholar, PubMed, CNKI, Wanfang and CQVIP.</div></div><div><h3>Results</h3><div>This study reviewed the chemical composition and pharmacological activities of <em>C. grandiflora</em> Benth. <em>in vitro</em> and <em>in vivo</em> studies indicate that <em>C. grandiflora</em> Benth. and its major bioactive constituents (iridoid glycosides) exhibit diverse pharmacological properties, including anti-myocardial ischemia, anticoagulant, anti-inflammatory, antioxidant, anticancer, antimicrobial, and hepatoprotective effects.</div></div><div><h3>Discussion</h3><div>Therefore, to facilitate the exploration and utilization of <em>C. grandiflora</em> Benth. resources, comprehensive investigations into the chemical composition and pharmacological properties of its remaining constituents are essential. This includes elucidating structure-activity relationships and mechanisms of action for its diverse constituents, thereby facilitating clinical applications and enhancing therapeutic efficacy.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"17 ","pages":"Article 100727"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145693357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phenolic content, antioxidant activities and antibacterial effects of Antidesma thwaitesianum Mull. Arg. extracts","authors":"Naruwat Pakdee,&nbsp;Ronnachai Poowanna","doi":"10.1016/j.prmcm.2025.100725","DOIUrl":"10.1016/j.prmcm.2025.100725","url":null,"abstract":"<div><h3>Introduction</h3><div><em>Antidesma thwaitesianum</em> (Chinese name: 小斑五月茶, Pinyin: xiǎo yè wǔ yuè chá), taxonomically associated with its synonym <em>Antidesma puncticulatum</em> is a fruit rich in phenolic compounds known for their health benefits as well as their antibacterial and antioxidant activities. This study aimed to analyze the phenolic compound content and antioxidant activity of <em>A. thwaitesianum</em> extracts, as well as to investigate their inhibitory effects on the growth of <em>Eschrichia coli, Aeromonas hydrophila, Bacillus</em> spp. and <em>Proteus mirabilis</em>.</div></div><div><h3>Methods</h3><div>The extracts were prepared by freshly squeezing the fruits and using 95 % ethanol as a solvent. The phenolic compound content was analyzed using the Folin - Ciocalteu method. Antioxidant activity was assessed using the DPPH assay, while antibacterial activity was evaluated using the disc diffusion method, minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC).</div></div><div><h3>Results</h3><div>The results showed that <em>A. thwaitesianum</em> black fruit extract exhibited the highest total phenolic content (116.48 ± 2.8 mg GAE/g), while the strongest antioxidant activity (IC₅₀ = 79.27 ± 1.88 mg/mL) occurred in red fruit water extract. whereas the red fruit ethanolic extract showed the strongest antibacterial activity with MIC values ranging from 0.98 - 250 µg/mL against tested bacteria.</div></div><div><h3>Discussion</h3><div>Ethanol extracts of <em>A. thwaitesianum</em> especially from black fruits, contained higher phenolic content, while red fruit water extracts showed the strongest antioxidant activity and red fruit ethanol extracts exhibited the most potent antibacterial effects. These results highlight the potential of <em>A. thwaitesianum</em> as a natural source of antioxidant and antibacterial agents for functional food and phytopharmaceutical applications.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"17 ","pages":"Article 100725"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145623889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the pharmacological promise of Tamarix chinensis Lour: An integrative review of phytochemical constituents, therapeutic potentials, and mechanistic pathways","authors":"Muhammad Tariq Saeed ,&nbsp;Jinghao Zhao ,&nbsp;Hassan Mohamed ,&nbsp;Tahira Naz ,&nbsp;Bushra Iqbal ,&nbsp;Asmaa S. Ramadan ,&nbsp;Hafiz Muhammad Saleem Akhtar ,&nbsp;Molalign Assefa ,&nbsp;Hina Khalid ,&nbsp;Yuanda Song ,&nbsp;Wenlong Sun","doi":"10.1016/j.prmcm.2025.100722","DOIUrl":"10.1016/j.prmcm.2025.100722","url":null,"abstract":"<div><h3>Introduction</h3><div><em>Tamarix chinensis</em> Lour (TCL) is a known arid plant belonging to the family <em>Tamaricaceae,</em> widely distributed near the Yellow River Delta, northeastern Shandong Province of China. The researchers have mainly focused on heat and salt alkaline resistance properties of TCL, but recently, it has gained significant attention for its wide range of pharmacological and therapeutically bioactive ingredients. The flavonoids, phenolics, terpenoids, volatiles, and other miscellaneous compounds are vital bioactive substances that demonstrate hepatoprotective, antioxidant, anti-inflammatory, cardio-protective, lung protection, anticancer, anti-complement, antidiabetic, neurological protection, and other bioactivities. This comprehensive review summarized the traditional medicinal uses, phytochemistry, therapeutic potential, and mechanistic insights, consolidating the current research on the medicinal potential of TCL<em>.</em></div></div><div><h3>Methods</h3><div>The information about TCL was collected from different reliable scholarly resources, like Chinese digital library, Google Scholar, Science Direct, and PubMed. Molecular docking was used to predict the interaction between six major compounds (Ellagic acid, Gallic acid, Isorhamnetin, Kaempferol, Quercetin, and Tamarixetin) and four target proteins, <span><span>tumor necrosis factor</span><svg><path></path></svg></span> (TNF-α), <span><span>interleukin 6</span><svg><path></path></svg></span> (IL-6), nuclear factor erythroid 2-related factor 2 (Nrf2), and peroxisome proliferator-activated receptor alpha (PPARα).</div></div><div><h3>Results</h3><div>These compounds demonstrated a significant binding affinity to TNF-alpha and ellagic acid showed bonding with IL-6 and showed the potential effects as antitumor and anti-inflammatory.</div></div><div><h3>Conclusion</h3><div>There is a critical need to deepen the understanding of the mechanisms of therapeutic properties underlying TCL efficacy and to establish robust quality standards and regulatory frameworks that ensure safety comparable to that of Western pharmaceuticals. The current evidence on the pharmacological properties of this plant explores that this plant could be a hopeful contender for drug development.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"17 ","pages":"Article 100722"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145623891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}