Pharmacological Research - Modern Chinese Medicine最新文献

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Pharmacological Research - Modern Chinese Medicine

Pub Date : 2026-01-01

引用次数: 0

Pharmacological Research - Modern Chinese Medicine

Pub Date : 2026-01-01

引用次数: 0

Pharmacological Research - Modern Chinese Medicine

Pub Date : 2026-01-01

引用次数: 0

Pharmacological Research - Modern Chinese Medicine

Pub Date : 2026-01-01

引用次数: 0

Pharmacological Research - Modern Chinese Medicine

Pub Date : 2026-01-01

引用次数: 0

Pharmacological Research - Modern Chinese Medicine

Pub Date : 2026-01-01

引用次数: 0

Pharmacological Research - Modern Chinese Medicine

Pub Date : 2026-01-01

引用次数: 0

Anti-inflammatory and antioxidant mechanisms of Morus species: Part-specific insights from traditional Chinese medicine 桑属植物的抗炎和抗氧化机制：部分来自中医的见解

Pharmacological Research - Modern Chinese Medicine

Pub Date : 2025-12-26 DOI: 10.1016/j.prmcm.2025.100749

Akash Bhati, Hemanth Kumar Boyina, Navneet Sharma

Introduction

Various parts of the Morus species have long been used in TCM, which are increasingly known for their anti-oxidant and anti-inflammatory properties. This review systematically explores the phytochemical composition and therapeutic relevance of Morus species within the TCM framework.

Methods

A comprehensive literature analysis was conducted across ScienceDirect.PubMed and Google Scholar, concentrating more on peer-reviewed English-language articles, clinical trials, and reviews published up to 2025.

Results

Out of the initial 297 sources identified, 165 were selected for relevance to Morus and its bioactive constituents. More emphasis has been placed on those studies providing part-specific information on leaves, bark, stems, fruits, twigs, and roots, which are commonly used in traditional formulations. The review maps the distribution of phytochemicals across these botanical parts and highlights their pharmacological actions with special attention to anti-inflammatory and antioxidant mechanisms. Key compounds discussed in relation to modulation of oxidative stress, inflammatory pathways, and possible clinical applications include flavonoids, alkaloids, and polyphenols.

Discussion

The current synthesis provides a comprehensive phytochemical profile of Morus species and emphasizes their therapeutic potential in the management of chronic inflammatory-degenerative disorders. Despite this promise, the effects await further confirmation by targeted pharmacological studies and well-designed clinical trials. Elucidation of the role of bioactive compounds from Morus species might help to include such compounds in evidence-based complementary medicine and drug development strategies.

桑树的不同部分长期以来一直被用于中医，其抗氧化和抗炎特性越来越为人所知。本文系统地探讨了桑科植物的化学成分及其在中医框架下的治疗意义。方法在ScienceDirect上进行综合文献分析。PubMed和谷歌Scholar，更多地关注同行评议的英语文章、临床试验和截至2025年发表的评论。结果在最初鉴定的297种来源中，筛选出165种与桑属植物及其生物活性成分相关的来源。更多的重点放在那些研究中，这些研究提供了叶子、树皮、茎、果实、树枝和根的特定部位的信息，这些通常用于传统配方。本文综述了植物化学物质在这些植物部位的分布，并强调了它们的药理作用，特别关注抗炎和抗氧化机制。讨论了与氧化应激调节、炎症途径和可能的临床应用相关的关键化合物包括黄酮类化合物、生物碱和多酚。目前的合成提供了桑葚种的全面植物化学概况，并强调了它们在慢性炎症退行性疾病治疗中的治疗潜力。尽管有这样的希望，效果还需要进一步的药理学研究和精心设计的临床试验来证实。阐明桑属植物中生物活性化合物的作用可能有助于将这些化合物纳入循证补充医学和药物开发战略。

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The hepatoprotective activity and chemical constituents of Helicteres hirsuta water extract 毛缕草水提取物的保肝活性及其化学成分

Pharmacological Research - Modern Chinese Medicine

Pub Date : 2025-12-26 DOI: 10.1016/j.prmcm.2025.100747

Thi Hong Tuoi Do , Van Ho Nam Phan , Thi Kim Anh Le , Phuong Ngoc Anh Le , Le Dan Thao Ha , Phan Thao Trang Nguyen , Truong Hoan Trong Nguyen , Thi Thu Hien Vo , Huong-Giang Le , Thi Van Anh Tran

Introduction

Many species belonging to the genus Helicteres are used in the traditional medicine of Asian countries. Helicteres hirsuta (雁婆麻) is widely distributed and cultivated in China but not used for medicinal purposes. However, the decoction of H. hirsuta has long been employed in Vietnamese folk medicine for managing hepatic disorders. The systematic pharmacological validation and phytochemical characterization of this plant remain inadequate. This study sought to elucidate the chemical constituents of the H. hirsuta water extract (HWE) and to assess its hepatoprotective efficacy through in vitro and in vivo models. The findings are expected to not only provide scientific evidence for its traditional use in Vietnam but also highlight the potential of H. hirsuta as a new, untapped therapeutic resource for Traditional Chinese Medicine.

Methods

HWE was fractionated by column chromatography, and isolated constituents were identified using spectroscopic techniques. Hepatoprotective activity was examined against paracetamol-induced cytotoxicity in HepG2 cells, while antioxidant capacity with DPPH radical scavenging and lipid peroxidation assays were assessed. Main bioactive constituents identified by UPLC–MS were quantified in HWE which was further investigated in vivo. Hepatoprotective effects of HWE (412.5 and 825 mg/kg) were evaluated in mice with paracetamol-induced hepatotoxicity (400 mg/kg). Serum biomarkers (ALT, AST, ALP, bilirubin), oxidative stress parameters (GSH, MDA), and histopathology were analyzed, using silymarin (100 mg/kg) as positive control.

Results

HWE exhibited pronounced hepatoprotective activity in vitro (EC₅₀ = 20.12 ± 0.15 µg/mL) with strong antioxidant potential (DPPH, IC₅₀ = 33.91 ± 0.48 µg/mL; MDA, IC₅₀ = 165.07 ± 8.60 µg/mL). Nine compounds were identified, including danshensu (>2 % w/w) as predominant constituent, rosmarinic acid, tiliroside, isoacteoside, forsythoside B, and four flavonoid glucuronides. In vivo, HWE significantly ameliorated biochemical and oxidative stress markers, with greater efficacy at 825 mg/kg.

Conclusion

HWE, particularly at 825 mg/kg, demonstrated significant hepatoprotective activity, attributable to polyphenolic constituents, notably danshensu. These findings scientifically substantiate traditional use and provide a foundation for therapeutic development.

亚洲国家的传统医药中使用了许多属于螺旋属的物种。毛毛螺杆菌（Helicteres hirsuta）在中国广泛分布和种植，但不用于药用。然而，毛缕草的汤剂长期以来一直被用于越南民间医学治疗肝病。该植物的系统药理验证和植物化学特性仍然不足。本研究旨在通过体外和体内模型，阐明毛螺水提取物（HWE）的化学成分，并评估其肝保护作用。这一发现不仅为其在越南的传统用途提供了科学证据，而且还突出了毛螺旋体作为一种新的、尚未开发的中药治疗资源的潜力。方法采用柱层析法对其进行分离，采用波谱技术对分离成分进行鉴定。研究了对乙酰氨基酚诱导的HepG2细胞毒性的肝保护活性，同时评估了DPPH自由基清除和脂质过氧化的抗氧化能力。通过UPLC-MS对HWE中的主要生物活性成分进行了定量分析，并在体内进行了进一步的研究。对扑热息痛致小鼠肝毒性（400 mg/kg），评价了HWE（412.5和825 mg/kg）对肝脏的保护作用。以水飞蓟素（100 mg/kg）为阳性对照，分析血清生物标志物（ALT、AST、ALP、胆红素）、氧化应激参数（GSH、MDA）和组织病理学。结果shwe在体外表现出明显的保肝活性（EC₅₀= 20.12±0.15µg/mL），具有很强的抗氧化潜力（DPPH, IC₅₀= 33.91±0.48µg/mL； MDA, IC₅₀= 165.07±8.60µg/mL）。共鉴定出9个化合物，主要成分为丹参素（% w/w）、迷迭香酸、铁力苷、异毛蕊苷、连翘苷B和4种类黄酮葡萄糖醛酸酯。在体内，HWE显著改善生化和氧化应激指标，在825 mg/kg时效果更显著。结论hwe在825 mg/kg时表现出明显的肝保护作用，这主要是由于其多酚类成分，尤其是丹参素。这些发现科学地证实了传统的使用，并为治疗发展提供了基础。

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Buyang Huanwu decoction in the treatment of stroke: A review 补阳还五汤治疗脑卒中的研究进展

Pharmacological Research - Modern Chinese Medicine

Pub Date : 2025-12-24 DOI: 10.1016/j.prmcm.2025.100748

Jinzhe Luo, Weibo Shao, Xiaojie Xue

<div><h3>Introduction</h3><div>Buyang Huanwu Decoction (BHD) is a traditional Chinese medicine (TCM) formula created by Wang Qingren during the Qing dynasty. It is renowned for its effects of <em>Tonify qi,</em><span><span><sup>1</sup></span></span> <em>Circulate blood, and Unblock meridians</em><span><span><sup>2</sup></span></span> and is widely used in the treatment of stroke, for conditions such as hemiplegia and facial paralysis. The formula comprises seven herbs (see Table 2 for the complete list), including <em>Astragalus membranaceus (Fisch.) Bunge, Angelica sinensis (Oliv.) Diels and Paeonia lactiflora Pall.</em> This paper aims to provide a systematic review of the research progress on BHD for stroke treatment from 2019 to December 2025, covering both clinical efficacy and the multidimensional mechanisms of action. The review seeks to address the shortcomings of previous reviews regarding the comprehensive of mechanisms and their timeliness, while providing references for the modernisation of TCM.</div></div><div><h3>Method</h3><div>In order to evaluate the therapeutic effects of BHD on stroke comprehensively, we retrieved relevant literature published between 2019 and December 2025 from Chinese and English databases, including CNKI, Wanfang Database, PubMed and Web of Science. Search keywords included “Buyang Huanwu Decoction”, “stroke”, “mechanism”, “neuroinflammation”, “gut-brain axis” and the herbs that make up the decoction. This review was compiled by synthesising findings from animal experiments and clinical studies.</div></div><div><h3>Results</h3><div>Preliminary, low-certainty evidence from the 19 included RCTs suggests that BHD, when combined with Western medicine or acupuncture, may be associated with potential improvements in certain clinical outcomes such as National Institutes of Health Stroke Scale (NIHSS) and Barthel Index(BL) scores; however, these findings are derived from studies with methodological limitations and require validation in more robust trials. Its mechanism of action is complex, characterized by multi-component, multi-target, and multi-pathway effects. More specifically, this formula regulates cerebral blood circulation, protects neurons, promotes regeneration and stabilises the blood-brain barrier (BBB). It also modulates the gut-brain axis.</div></div><div><h3>Discussion</h3><div>This review summarises the available evidence on the efficacy and pharmacological mechanisms of BHD at different stages of stroke. While the findings may inform targeted clinical applications, further validation is required. However, current research is largely confined to animal or cellular experiments and lacks direct evidence from human studies. There are ongoing challenges in clinical practice, including dosage optimisation and herb-drug interactions. Future studies may overcome these limitations by leveraging systems biology and metabolomics, and through deeper exploration of gut-brain axis mechanisms. Concurrently, the d

补阳还五汤（BHD）是清朝王庆仁发明的传统中药配方。它以其补气、活血、通络的功效而闻名，被广泛用于治疗中风、偏瘫和面瘫等病症。该配方由七种草药组成（完整列表见表2），其中包括黄芪（黄芪属）。邦吉，当归（橄榄）丹参与芍药。本文旨在对2019年至2025年12月BHD治疗脑卒中的研究进展进行系统综述，包括临床疗效和多维作用机制。本综述旨在弥补以往综述在机制综合性和及时性方面的不足，同时为中医药现代化提供参考。方法为了全面评价BHD对脑卒中的治疗效果，我们从CNKI、万方数据库、PubMed、Web of Science等中英文数据库中检索2019年至2025年12月发表的相关文献。搜索关键词包括“补阳还五汤”、“中风”、“机制”、“神经炎症”、“肠脑轴”以及组成该汤的草药。这篇综述是通过综合动物实验和临床研究的结果编写的。结果19项纳入的随机对照试验的初步、低确定性证据表明，BHD与西药或针灸联合治疗可能与某些临床结果的潜在改善有关，如美国国立卫生研究院卒中量表（NIHSS）和Barthel指数（BL）评分；然而，这些发现来自有方法学局限性的研究，需要在更可靠的试验中进行验证。其作用机制复杂，具有多组分、多靶点、多途径作用的特点。更具体地说，这个配方调节脑血循环，保护神经元，促进再生和稳定血脑屏障（BBB）。它还调节肠脑轴。本文综述了BHD在脑卒中不同阶段的疗效和药理机制的现有证据。虽然这些发现可能为有针对性的临床应用提供信息，但还需要进一步的验证。然而，目前的研究主要局限于动物或细胞实验，缺乏来自人体研究的直接证据。在临床实践中存在持续的挑战，包括剂量优化和草药-药物相互作用。未来的研究可能会通过利用系统生物学和代谢组学，以及通过对肠-脑轴机制的更深入探索来克服这些局限性。同时，新配方的开发，如纳米载体，有望提高生物利用度和疗效，从而最大限度地发挥其治疗潜力

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