Pharmacological Research - Modern Chinese Medicine最新文献

{"title":"Integrated network, docking, and experimental validation of the dual anti-inflammatory and uricosuric actions of Artemisia vulgaris compounds","authors":"Pham Thi Nhat Trinh ,&nbsp;Dang Thi Le Hang ,&nbsp;Nguyen Ngoc Phuong Uyen ,&nbsp;Tran Nguyen Minh An ,&nbsp;Le Xuan Tien ,&nbsp;Le Tien Dung","doi":"10.1016/j.prmcm.2025.100712","DOIUrl":"10.1016/j.prmcm.2025.100712","url":null,"abstract":"<div><div>In Traditional Chinese Medicine (TCM), mugwort (<em>Artemisia vulgaris</em>) is documented as the primary material for moxibustion, prepared as moxa floss (<em>ai rong</em>, 艾绒), moxa cones (<em>ai zhu</em>, 艾炷), and moxa sticks (<em>ai tiao</em>, 艾条) to warm the channels and regulate qi–blood [6–8]. We therefore investigated <em>A. vulgaris</em> compounds for multi-target anti-gout relevance, anchored in these TCM indications.</div><div>Network pharmacology and molecular docking prioritized A. vulgaris phytochemicals against gout-related targets, followed by in-vitro validation in LPS-challenged RAW 264.7 macrophages.</div><div>Of 62 compounds, 52 met drug-likeness and intersected 277 gout genes. A flavonoid (AV52) showed strong predicted binding to PTGS2/XO, and artemisinin (AV46) to urate transporters (SLC22A12/ABCG2). Experimentally, AV46 reduced IL-6/TNF-α and nitrite while preserving IL-10. IL-10 showed a small, non-monotonic change at 6.25 µM (<em>p</em> &lt; 0.05) that was not reproduced at adjacent doses, suggesting limited biological relevance, while overall IL-10 was preserved alongside reductions in IL-6 and TNF-α.</div><div>Framed within TCM practice of moxibustion and warming/qi–blood-regulating indications, these data support a lead–anchor concept (AV52 anti-inflammatory/XO; AV46 uricosuric-anti-inflammatory) warranting further in-vivo and formulation studies for TCM-relevant applications.</div><div>A. vulgaris phytochemicals demonstrate complementary potential against gout-related inflammation and urate handling within a TCM use-case anchored to mugwort preparations (moxa floss/cones/sticks). AV46 showed experimental activity consistent with predictions, while AV52 requires bench confirmation. These results motivate focused biochemical, transporter, pharmacokinetic, and in-vivo evaluations to support translation into Chinese preparation - compatible applications.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"17 ","pages":"Article 100712"},"PeriodicalIF":0.0,"publicationDate":"2025-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145417214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanistic insights into the neuroprotective effects of Radix Astragali (Huang Qi): Bridging Traditional Chinese Medicine and modern pharmacology","authors":"Rizwan Ahmad ,&nbsp;Chhavi Verma ,&nbsp;Sandeep Kumar ,&nbsp;Vishal Kumar ,&nbsp;Darakhshan Gazala Bari ,&nbsp;Saurabh Sharma ,&nbsp;Shadab Ali ,&nbsp;Shamim Shamim","doi":"10.1016/j.prmcm.2025.100711","DOIUrl":"10.1016/j.prmcm.2025.100711","url":null,"abstract":"<div><h3>Introduction</h3><div><em>Radix Astragali</em>, a major herb in Traditional Chinese Medicine, has traditionally been used to strengthen vital energy and promote blood circulation. Recent research has revealed its neuroprotective potential in disorders such as ischemic stroke, Alzheimer’s disease, and traumatic brain injury.</div></div><div><h3>Methods</h3><div>This review evaluates recent preclinical and clinical studies on the neuroprotective effects of <em>Radix Astragali</em> and its active components, including astragaloside four, flavonoids, polysaccharides, terpenoids, alkaloids, and amino acids. Peer-reviewed scientific literature was analyzed and interpreted within the context of Traditional Chinese Medicine principles.</div></div><div><h3>Results</h3><div><em>Radix Astragali</em> exhibits multiple neuroprotective actions, including antioxidant, anti-inflammatory, anti-apoptotic, and immune-regulating effects. Astragaloside IV regulates critical signaling pathways, including phosphoinositide 3-kinase/protein kinase B, mitogen-activated protein kinase, and nuclear factor-κB, thereby supporting neuronal survival and reducing oxidative damage. Flavonoids and polysaccharides enhance synaptic plasticity, nerve regeneration, and cerebral blood flow. These findings are consistent with Traditional Chinese Medicine concepts of replenishing vital energy and stimulating blood flow in neurological disorders.</div></div><div><h3>Discussion</h3><div><em>Radix Astragali</em> exemplifies the integration of Traditional Chinese Medicine and modern neuropharmacology. However, clinical translation remains limited due to challenges in standardization, potential herb drug interactions, and insufficient large-scale clinical validation. Future studies should emphasize pharmacokinetics, synergistic formulations, and biomarker-based personalized neurotherapy to ensure safe and effective clinical application.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"17 ","pages":"Article 100711"},"PeriodicalIF":0.0,"publicationDate":"2025-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145417334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic modulation of unfolded protein response by biochemic tissue salts in alcohol- and acetaminophen-induced liver cirrhosis","authors":"Debabrata Dash,&nbsp;Raj Kumar Koiri","doi":"10.1016/j.prmcm.2025.100710","DOIUrl":"10.1016/j.prmcm.2025.100710","url":null,"abstract":"<div><h3>Introduction</h3><div>Alcohol-associated liver disease (ALD) is a major global public health problem with chronic alcohol use responsible for a large proportion of alcohol-attributed fatalities. The combined exposure to acetaminophen raises the level of hepatotoxicity. The unfolded protein response (UPR) is one of the key cellular processes stimulated following liver injury but whose regulation under dual alcohol and acetaminophen treatment is ill defined. While Natrum sulphuricum (NS) and Natrum phosphoricum (NP) are Western biochemic homeopathic tissue salts, mineral salts and allied compounds have been traditionally used in Traditional Chinese Medicine (TCM) for the upkeep of liver and digestive functions. The present study was aimed at ascertaining hepatoprotective action of NS and NP through modulation of UPR signaling in chemically induced liver cirrhosis rat model.</div></div><div><h3>Methods: Wistar albino rats were divided at random into five groups</h3><div>control, alcohol control, liver cirrhosis, LC+NS, and LC+NP. Liver cirrhosis was induced by chronic oral treatment with alcohol and acetaminophen. NS and NP were given orally for four weeks following induction. Liver tissues were taken for molecular analysis, and expression of a few of the major UPR-related genes and proteins were quantified by quantitative RT-PCR and Western blotting.</div></div><div><h3>Results</h3><div>Both acetaminophen and alcohol coexposures significantly dysregulated UPR markers, suggesting endoplasmic reticulum stress and altered proteostasis. NP and NS treatment restored levels of key UPR components, suggesting therapeutic protein-folding mechanism modulation.</div></div><div><h3>Conclusions</h3><div>NS and NP showed hepatoprotective action through UPR signaling modulation and reduction of protein-misfolding stress in chemically induced liver cirrhosis. These results are preliminary scientific basis to explore mineral-based compounds in new and traditional medicine settings, including their theoretical significance to TCM approaches to the prevention of liver disease.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"17 ","pages":"Article 100710"},"PeriodicalIF":0.0,"publicationDate":"2025-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145363238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"To explore the scientific connotation of Fuyang therapy for liver cancer based on mitochondrial function","authors":"Yang Wang ,&nbsp;Bugao Zhou ,&nbsp;Shanshan Li ,&nbsp;Linxin Zheng ,&nbsp;Bohan Cai ,&nbsp;Huiyu Wang ,&nbsp;Sili Li ,&nbsp;Yuhan Lin ,&nbsp;Yanhe Xu","doi":"10.1016/j.prmcm.2025.100709","DOIUrl":"10.1016/j.prmcm.2025.100709","url":null,"abstract":"<div><h3>Background</h3><div>Liver cancer poses a serious threat to human health,and research into its pathogenesis and exploration of treatment strategies have always been major focuses in the medical field.Recent studies have indicated that mitochondrial dysfunction plays a promoting role in the progression of liver cancer,primarily manifested through disruptions in energy metabolism,decreased mitochondrial outer membrane permeability, and dysregulation of calcium ion homeostasis. In traditional Chinese medicine (TCM), “Yang deficiency and Yin excess” is considered the core pathogenesis of liver cancer, and the fundamental treatment principle of “Fuyang Guben” (supporting Yang and reinforcing the root) has been proposed. The mechanism of action may be associated with the improvement of mitochondrial function, however modern research in this area remains relatively limited.</div></div><div><h3>Methods</h3><div>Through theoretical analysis and comprehensive literature review, this paper elucidates the theoretical basis of Fuyang therapy for liver cancer from the perspective of TCM theory,summarizes the specific roles of mitochondrial function in the progression of liver cancer, and systematically reviews recent advances in modern mechanistic research on how Fuyang therapy inhibits the occurrence and development of liver cancer by regulating mitochondrial function.</div></div><div><h3>Results</h3><div>Fuyang therapy can improve mitochondrial function from multiple perspectives,including restoring energy metabolism,regulating membrane permeability, and maintaining calcium homeostasis,thereby inhibiting the proliferation and progression of liver cancer cells.Existing experimental and clinical studies have preliminarily verified the potential efficacy of Fuyang-based formulas in anti-liver cancer treatments and their regulatory mechanisms involving mitochondrial function-related pathways.</div></div><div><h3>Conclusion</h3><div>Fuyang therapy demonstrates both theoretical rationality and experimental support in the treatment of liver cancer.Its anti-liver cancer effects are achieved through the improvement of mitochondrial function,providing new insights for the formulation of TCM-based treatments and mechanistic research on liver cancer.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"17 ","pages":"Article 100709"},"PeriodicalIF":0.0,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145363236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of Traditional Chinese medicinal plants in the management of fibromyalgia: A review","authors":"Kaniga Pandi,&nbsp;Binoy Varghese Cheriyan,&nbsp;Kunal R. Kataria","doi":"10.1016/j.prmcm.2025.100707","DOIUrl":"10.1016/j.prmcm.2025.100707","url":null,"abstract":"<div><h3>Introduction</h3><div>Fibromyalgia is a chronic, multifactorial disorder characterized by widespread musculoskeletal pain, fatigue, sleep disturbances, and cognitive impairments, substantially reducing quality of life. Conventional pharmacological therapies, including analgesics, antidepressants, and anticonvulsants, provide only partial relief and are often associated with adverse effects. This highlights the need for safer and more effective alternatives. Traditional Chinese Medicine (TCM) has a long history of managing chronic pain conditions through medicinal plants, which may offer therapeutic benefits in fibromyalgia.</div></div><div><h3>Methods</h3><div>A systematic literature search was performed across PubMed, Scopus, Web of Science, and CNKI databases using predetermined inclusion and exclusion criteria. The focus was on studies reporting the phytochemical composition, pharmacological actions, and clinical outcomes of TCM medicinal plants relevant to fibromyalgia.</div></div><div><h3>Results</h3><div>Several plants with potential therapeutic effects were identified, including <em>Panax ginseng</em> (Ren Shen), <em>Corydalis yanhusuo</em> (Yan Hu Suo), <em>Salvia miltiorrhiza</em> (Dan Shen), and <em>Astragalus membranaceus</em> (Huang Qi). Their bioactive compounds, ginsenosides, tetrahydropalmatine, salvianolic acids, ferulic acid, and astragalosides, exert multimodal actions. These include modulation of neurotransmitter pathways, reduction of pro-inflammatory cytokines, antioxidative activity, and improvement of mitochondrial function. Preclinical studies demonstrate analgesic, anti-fatigue, and neuroprotective effects, while limited clinical evidence suggests improvements in pain, sleep, and overall well-being.</div></div><div><h3>Discussion</h3><div>Although preliminary findings are promising, current evidence is limited by small sample sizes, heterogeneous herbal formulations, and lack of standardized dosing regimens. Well-designed, large-scale randomized controlled trials are essential to validate efficacy, establish safety profiles, and support the integration of TCM herbal therapies into evidence-based fibromyalgia management.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"17 ","pages":"Article 100707"},"PeriodicalIF":0.0,"publicationDate":"2025-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145417335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ameliorative effects of traditional Chinese medicine formula NRICM101 on periodontal inflammation: In vitro and in vivo","authors":"Fang-Wei Lin ,&nbsp;Yann-Jen Chen ,&nbsp;Hui-Rong Cheng ,&nbsp;Chi-Tsung Wu ,&nbsp;Hsien-Chung Chiu","doi":"10.1016/j.prmcm.2025.100708","DOIUrl":"10.1016/j.prmcm.2025.100708","url":null,"abstract":"<div><h3>Introduction</h3><div>Taiwan Chingguan Yihau (NRICM101) is a novel anti-inflammatory traditional Chinese medicine formula developed in 2020 for COVID-19 pandemic. This study aimed to evaluate the effect of NRICM101 on periodontal inflammation, using human gingival fibroblasts (HGFs) exposed to <em>Porphyromonas gingivalis</em> lipopolysaccharide (Pg LPS) and rat models of ligature-induced periodontitis.</div></div><div><h3>Methods</h3><div><em>In vitro</em>, HGFs were stimulated with Pg LPS and NRICM101. Cell viability and the expression of pro-inflammatory cytokines, including interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and IL-1β were measured using MTS assay and reverse transcription quantitative polymerase chain reaction (RT-qPCR). <em>In vivo</em>, Sprague-Dawley rats were divided into control, ligature placement, and NRICM101 treatment groups. Ligature placement was performed at day one and oral administration of NRICM101 (50 or 100 mg/kg body weight/day) or saline began one day prior to ligation and the following days. On day 8, the rats were sacrificed, periodontal tissue specimens were analyzed using microcomputed tomography (Micro-CT) imaging, RT-qPCR, and immunohistochemical (IHC) staining to evaluate the effects of the treatments.</div></div><div><h3>Results</h3><div>NRICM101 reduced HGFs viability above 1.0 mg/mL, while Pg LPS caused similar effects at concentrations above 1.0 μg/mL. Co-treatment with Pg LPS (0.5–1.0 μg /mL) and NRICM101 (0.1–0.5 mg/mL) showed no cytotoxicity. <em>In vivo</em>, NRICM101 attenuated alveolar bone loss and significantly decreased IL-6, TNF-α, and partially IL-1β expression, as confirmed by micro-CT, RT-qPCR, and IHC analyses.</div></div><div><h3>Discussion</h3><div>This study demonstrates that NRICM101 exerts protective anti-inflammatory effects in both cellular and animal models of periodontitis. It suppressed pro-inflammatory cytokine expression in HGFs and mitigated alveolar bone loss in ligature-induced periodontitis rats. The effects on IL-6 and TNF-α were pronounced, while the partial reduction of IL-1β may reflect additional regulatory mechanisms such as inflammasome activation, which warrants further investigation. These findings indicate that NRICM101 reduces inflammation without cytotoxicity and supports its potential application in managing chronic periodontal inflammation.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"17 ","pages":"Article 100708"},"PeriodicalIF":0.0,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145363239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating traditional chinese medicine and modern pharmacology: The role of Jiang Huang (curcumin) in cardiovascular health","authors":"Rufaida Wasim ,&nbsp;Sumaiya Azmi ,&nbsp;Asad Ahmad","doi":"10.1016/j.prmcm.2025.100706","DOIUrl":"10.1016/j.prmcm.2025.100706","url":null,"abstract":"<div><h3>Introduction</h3><div><strong>:</strong> Cardiovascular diseases (CVDs) remain the leading global cause of morbidity and mortality, driven by mechanisms such as oxidative stress, endothelial dysfunction, inflammation, and lipid imbalance. Curcumin, the principal bioactive constituent of <em>Curcuma longa</em> (turmeric), has long been used in Traditional Chinese Medicine (TCM) to improve circulation and alleviate stasis. Modern pharmacological evidence suggests it may offer cardiovascular protection.</div></div><div><h3>Methods</h3><div><strong>:</strong> This review synthesises findings from preclinical models, clinical studies, and molecular investigations of curcumin in CVD, alongside traditional perspectives from TCM for integrative context.</div></div><div><h3>Results</h3><div><strong>:</strong> Experimental studies reveal that curcumin reduces oxidative stress, downregulates NF-κB and pro-inflammatory cytokines, enhances nitric oxide bioavailability, and inhibits vascular smooth muscle proliferation. In animal models, it decreases myocardial infarct size, attenuates hypertrophy, and improves ventricular function. Clinical trials report improvements in blood pressure, endothelial function, lipid regulation, and inflammatory biomarkers among individuals at cardiovascular risk. However, outcomes remain inconsistent due to variability in study design, small sample sizes, heterogeneous formulations, and limited duration of follow-up. TCM perspectives on promoting blood flow and reducing stasis align with curcumin’s observed effects on vascular remodeling and atherosclerosis.</div></div><div><h3>Discussion</h3><div><strong>:</strong> Curcumin is a safe, pleiotropic compound with growing evidence for adjunctive use in CVD management. Its poor oral bioavailability remains a key limitation, highlighting the need for novel formulations. Well-designed, larger clinical trials are essential to establish efficacy and bridge traditional knowledge with modern cardiovascular therapeutics.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"17 ","pages":"Article 100706"},"PeriodicalIF":0.0,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145363237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laiyang pear cough syrup relieves cough through the PI3K-AKT pathway","authors":"Haoling Liu ,&nbsp;Yiying Zhao ,&nbsp;Yige Zhao ,&nbsp;Kairui Gao ,&nbsp;Yawen Xue ,&nbsp;Dongyue Ma ,&nbsp;Jia Liu ,&nbsp;Zhenquan Liu ,&nbsp;Wenyan Sun","doi":"10.1016/j.prmcm.2025.100702","DOIUrl":"10.1016/j.prmcm.2025.100702","url":null,"abstract":"<div><h3>Objective</h3><div>To predict the mechanism of action of Laiyang Pear Cough Syrup in treating cough by using network pharmacology, molecular docking technology and the predicted key pathways in animal experiments.</div></div><div><h3>Methods</h3><div>Chemical components of each medicinal flavor were collected and screened from TCMSP and other databases to establish a database of the components of Laiyang Pear Cough Syrup. Cough-related targets were obtained from TTD and other databases. A Venn diagram of the components targets and cough targets was drawn to prelim determine the potential targets of the active ingredients of Laiyang Pear Cough Syrup in the treatment of cough. A PPI network was constructed and key targets were screened. The data were into Cytoscape 3.10.1 software, and a \"active component-disease target\" network was constructed, and key components were screened. The screened targets were subjected to GO enrichment analysis and KEGG pathway enrichment analysis. Molecular docking verification between key targets and core active ingredients was conducted using AutoDock Tools 1.5.6 software. A citric acid-induced guinea pig cough model was established. The cough latency and cough frequency were measured in the control and treatment groups, and the PI3K-AKT pathway predicted by network pharmacology was validated via Western blot analysis.</div></div><div><h3>Results</h3><div>43 active chemical components, 76 common targets, 591 GO biological processes, and 159 KEGG signaling pathways were screened out. The active components of Laiyang Pear Cough Syrup in the treatment of cough may be quercetin, stigmasterol, and luteolin, and the key may be IL-6, TNF, AKT1, IL-1β, and PTGS₂, which mainly regulate the PI3K/AKT pathway to relieve cough. Molecular docking revealed that luteolin, quercetin, and stigmasterol as the key active ingredients in Laiyang Pear Cough Syrup bind to AKT1 with high affinities, displaying docking scores of −8.1, −8.0, and −7.7 kcal mol⁻¹. These results indicate that the compounds may function as potent agonists to activate the PI3K-AKT signaling pathway. Laiyang Pear Cough Syrup can significantly prolong the cough latency period and reduce the number of coughs (compared with the control group, <em>P</em> &lt; 0.01 or 0.05), and down-regulate the expression of PI3K, p-PI3K, AKT, p-AKT proteins.</div></div><div><h3>Conclusion</h3><div>Laiyang Pear Cough Syrup can relieve cough through a variety of components, targets and pathways. Regulating the PI3K-AKT pathway may be its main mechanism of action.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"17 ","pages":"Article 100702"},"PeriodicalIF":0.0,"publicationDate":"2025-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145321065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of traditional Chinese medicine in combating metabolic disorders: A systematic review","authors":"Arpan Pathak ,&nbsp;Mohit Agrawal ,&nbsp;Pranshul Sethi ,&nbsp;Kantrol Kumar Sahu ,&nbsp;Monika Sharma ,&nbsp;Hema Chaudhary ,&nbsp;Devesh Kumar ,&nbsp;Thakur Gurjeet Singh ,&nbsp;Mohit Kumar","doi":"10.1016/j.prmcm.2025.100703","DOIUrl":"10.1016/j.prmcm.2025.100703","url":null,"abstract":"<div><h3>Introduction</h3><div>Metabolic disorders, including type 2 diabetes, obesity, hyperuricemia, and MASLD, are increasing worldwide, and conventional therapies often have limited efficacy. Traditional Chinese Medicine (TCM), with its multi-targeted approach, shows promise as a complementary strategy.</div></div><div><h3>Methods</h3><div>A systematic literature search was conducted in PubMed and CNKI (1966–2024) using predefined keywords related to TCM, metabolic disorders, clinical trials, and mechanisms. Eligible studies were screened and synthesized according to PRISMA guidelines to evaluate pharmacological pathways and therapeutic outcomes.</div></div><div><h3>Results</h3><div>Numerous TCM studies, including those on berberine, ginsenosides, bavachinin, and resveratrol, as well as formulations such as Shenge Formula, Huangqin Decoction, and Zibu Piyin Formula, have demonstrated the ability to regulate AMPK, PPARα, SIRT1, PI3K/Akt, and NF-κB signalling pathways. These interventions improve insulin resistance, lipid metabolism, inflammation, oxidative stress, and hepatic steatosis, with most findings derived from <em>in vitro and in vivo</em> studies.</div></div><div><h3>Conclusion</h3><div>TCM holds significant therapeutic potential for managing a spectrum of metabolic disorders through multi-target interventions that act on multiple interconnected biological systems. While preclinical and some clinical data support the efficacy and safety of TCM, further well-designed randomized clinical trials and integrated omics-based research are necessary to elucidate precise mechanisms, standardize formulations, and validate long-term outcomes. Integration of TCM into modern metabolic therapy may offer novel strategies for personalized and holistic healthcare.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"17 ","pages":"Article 100703"},"PeriodicalIF":0.0,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145321496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic potential of flavonoid-enriched Chinese medicinal herbs in atherosclerosis, hypertension, myocardial infarction, and heart failure","authors":"Dharshini Jaisankar,&nbsp;Suruthi Ramamoorthy,&nbsp;Jubilee Ramasamy","doi":"10.1016/j.prmcm.2025.100701","DOIUrl":"10.1016/j.prmcm.2025.100701","url":null,"abstract":"<div><h3>Introduction</h3><div>CVDs such as atherosclerosis, hypertension, myocardial infarction, and heart failure, are the top cause of death worldwide. Due to the challenges with traditional therapies, interest in complementary treatments has increased. Research has found that TCM and its herbal constituents, rich in flavonoids, appear to have a positive effect on cardiovascular health due to several underlying mechanisms.</div></div><div><h3>Methods</h3><div>This review provides an overview of current clinical and experimental research on flavonoid-rich Chinese medicinal plants. The database includes PubMed, Scopus, Web of Science, and CNKI. Details include various cardiovascular diseases (CVD) types and their mechanism of action (including antioxidant, anti-inflammation, enhancement of endothelial function, and stabilization of mitochondria). It also features studies of several compounds in preclinical models and clinical trials, including quercetin and baicalin as key representatives. Significant portion pathways are PI3K/AKT, NF-κB, Nrf2/HO-1, eNOS and AMPK/mTOR. The comparative table highlights plants, pharmaceutical targets, and the impact of diseases.</div></div><div><h3>Result</h3><div>Evidence suggests that flavonoids from Chinese medicinal plants have a wide-ranging cardio-protective effect, regardless of the CVD model. The compounds possess potent antioxidant, anti-inflammatory, endothelial-enhancing, and lipid-regulatory effects. While recent clinical studies indicate improvements in blood pressure, lipid profiles, myocardial resilience, and endothelial function, results remain inconsistent due to small sample size, differences in extract composition, and variation in trial design.</div></div><div><h3>Discussion</h3><div>The use of Chinese medicinal herbs enriched in flavonoids can provide effective multi-pathway intervention against complex pathophysiological mechanisms, making them a valuable resource for cardiovascular therapy. Despite the obvious translational potential, shortcomings like poor bioavailability, phytochemical variability, and limited clinical trials are significant. These limitations continue to hinder clinical translation, and addressing them will be critical for broder therapeutic adoption. Future research should focus on improving the formulation, facilitating clinical standardization, and developing systems-level pharmacology to enable evidence-based use of flavonoid therapies in modern cardiovascular medicine.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"17 ","pages":"Article 100701"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145268679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}