Pharmacological Research - Modern Chinese Medicine最新文献

{"title":"Unlocking therapeutic precision: “Camptotheca acuminata, a traditional chinese herb tailored for phytonano-cancer theranostics”","authors":"Debojyoti Adak ,&nbsp;Priyanka Ray ,&nbsp;Saini Setua","doi":"10.1016/j.prmcm.2024.100447","DOIUrl":"10.1016/j.prmcm.2024.100447","url":null,"abstract":"<div><h3>Introduction</h3><p>In recent years, there has been a growing interest in leveraging traditional medicinal plants for modern therapeutic approaches, particularly in cancer treatment. The review explores the potential of <em>Camptotheca acuminata,</em> a traditional Chinese plant, in cancer treatment through innovative phytonano-based drug delivery systems. <em>Camptotheca acuminata</em> contains camptothecin, a potent anticancer compound, but its therapeutic use is hindered by poor solubility, bioavailability, and systemic toxicity. The study highlights how phytonano-technology can enhance therapeutic accuracy and reduce side effects by using nanoparticles to encapsulate and selectively deliver drugs directly to cancer cells. This approach could significantly improve oncology therapy by addressing the limitations of traditional chemotherapy.</p></div><div><h3>Methods</h3><p>Using PubMed and Scopus, prospective research on the medicinal and anticancer activities of several Chinese mushroom species during the past 20 years were searched. The query included \"<em>Camptotheca acuminata</em>,\" \"cancer,\" \"nanoparticles,\" \"traditional Chinese medicine,\" and \"theranostics.\" Only entire English-language articles were used.</p></div><div><h3>Results</h3><p>Phytonano-Cancer Theranostics with camptothecin effectively targets cancer cells, showing substantial uptake in vitro and prolonged circulation and accumulation at tumor sites in vivo. These results demonstrate its potential for precise and effective cancer therapy.</p></div><div><h3>Discussion</h3><p>The integration of camptothecin with Phytonano-Cancer Theranostics offers promising targeted drug delivery and theranostic capabilities in cancer therapy. However, challenges remain, including optimizing nanoparticle design for stability, scalability, and biocompatibility, and overcoming biological barriers for efficient tumor targeting. Addressing these challenges requires interdisciplinary research to maximize the potential of innovative strategies and improve cancer patient outcomes.</p></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"11 ","pages":"Article 100447"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667142524000885/pdfft?md5=0ea920c2d50e7a2ef620877f8e506e62&pid=1-s2.0-S2667142524000885-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141141129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ilex pubescens inhibits pyroptosis post-myocardial infarction through suppression of the ROS/NLRP3 pathway","authors":"Ting-fang Chen ,&nbsp;Xiao-yu Jue ,&nbsp;Jun-bang Chen ,&nbsp;Bo Deng ,&nbsp;Ke-feng Zeng ,&nbsp;Si Chen ,&nbsp;Zhang-bin Tan ,&nbsp;Yong-zhen Tan ,&nbsp;Bin Liu ,&nbsp;Jing-zhi Zhang ,&nbsp;Shuang-wei Zhang","doi":"10.1016/j.prmcm.2024.100455","DOIUrl":"10.1016/j.prmcm.2024.100455","url":null,"abstract":"<div><h3>Introduction</h3><p><em>Ilex pubescens</em> (IPES), a traditional Chinese herb widely used in cardiovascular diseases, has shown potential anti-inflammatory capabilities in myocardial infarction. Reactive Oxygen Species (ROS) and the NOD-like Receptor Protein 3 (NLRP3) pathway are significant contributors to aseptic inflammation in heart diseases. This study aims to elucidate the primary mechanism by which IPES inhibits pyroptosis post-myocardial infarction.</p></div><div><h3>Methods</h3><p>By ligating the left coronary artery in C57BL/6 mice, a myocardial infarction model was established to be conducted <em>in vivo.</em> To establish pyroptosis <em>in vitro</em>, primary neonatal cardiomyocytes, extracted from the hearts of Sprague-Dawley rats, were treated in an oxygen-glucose deprivation way. ROS scavenger, NLRP3 inhibitor, and NLRP3 was overexpressed by adenovirus to confirm IPES inhibiting myocardial pyroptosis through the ROS/NLRP3 pathway.</p></div><div><h3>Results</h3><p><em>In vivo</em>, IPES exerted significant cardioprotective effects, as evidenced by reducing heart injury, improving cardiac function, and decreasing serum markers of cardiac damage. Furthermore, IPES treatment significantly inhibits ROS generation and reduces the expression levels of NLRP3 and its downstream pyroptosis-related proteins. <em>In vitro</em>, IPES therapy significantly decreased cell damage and pyroptosis in a concentration-dependent manner in an oxygen-glucose deprivation/re-oxygenation (OGD/R) cell model. Additionally, IPES demonstrates synergistic cardiomyocyte protection with the ROS scavenger NAC, whereas its inhibition of pyroptosis is not significantly different from that of the NLRP3 inhibitor. More importantly, the inhibitory impacts of IPES on pyroptosis were partially reversed by NLRP3 overexpression. The active components of IPES exhibit the ability to stably and efficiently bind with NLRP3.</p></div><div><h3>Discussion</h3><p>These results demonstrate that IPES inhibit pyroptosis post-MI by suppressing the ROS/NLRP3 pathway, providing a new insight into its potential application in treating MI.</p></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"11 ","pages":"Article 100455"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667142524000976/pdfft?md5=1efb2707ceeeff84467bd9437ba4a6a9&pid=1-s2.0-S2667142524000976-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141277456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-vivo evaluation of neuroprotective effect of Chinese plant calendula officinalis Linn. Flower Extract against Aluminium chloride-induced Alzheimer's in Wistar rats","authors":"Yash Jasoria ,&nbsp;Mohit Agrawal ,&nbsp;Shivendra Kumar ,&nbsp;Hema Chaudhary ,&nbsp;Kantrol Kumar Sahu ,&nbsp;Manmohan Singhal ,&nbsp;Swamita Arora ,&nbsp;Priyanka Chandolia ,&nbsp;Sunam Saha ,&nbsp;Kuldeep Singh ,&nbsp;Sangeeta Mahour ,&nbsp;Wasim Akram ,&nbsp;Divya Jain","doi":"10.1016/j.prmcm.2024.100458","DOIUrl":"10.1016/j.prmcm.2024.100458","url":null,"abstract":"<div><h3>Objective</h3><p>To investigate the neuroprotective properties of <em>Calendula Officinalis</em> Linn. flower extract (COE) against mild cognitive decline and cognitive dysfunction induced by aluminium chloride (AlCl₃) in experimental rats.</p></div><div><h3>Methodology</h3><p>COE (100, 200, and 300 mg/kg p.o.) was given once daily following the treatment of AlCl₃ (100 mg/kg p.o.) to male Wistar rats for 20 days. On the 1st, 10th, and 20th days, the walking track test, locomotor activity, and object recognition test were used as behaviour characteristics to assess spatial and non-spatial memory. On the 21st day, animals were sacrificed and brains removed for biochemical and histopathological analysis.</p></div><div><h3>Results</h3><p><em>Calendula officinalis</em> Linn. extract significantly attenuated the ^AlCl₃^-induced alterations in body weight, and motor coordination such as locomotion, stride length, and object recognition parameters. COE also reduced oxidative stress by increasing GSH, catalase, SOD, and decreasing TBARS levels. <em>Calendula officinalis</em> Linn. extract high dose showed most prominent therapeutic effects. <em>P</em> &lt; 0.05 and mean ± SD were used to compare mean values with normal control, disease control, and high doses of <em>Calendula officinalis</em> Linn. extract.</p></div><div><h3>Discussion</h3><p>Based on our study, oxidative stress has been proposed as a mechanism for AlCl₃-induced neurotoxicity. We conclude that <em>Calendula officinalis</em> Linn. flower extract substantially decreased oxidative stress and behavioural alterations in rats treated with aluminium chloride. <em>Calendula officinalis</em> flowers may provide significant neuroprotective effects, potentially improving memory and learning abilities. <em>Calendula officinalis Linn</em> flower extract contains anti-inflammatory and antioxidant effects that might be responsible for its neuroprotective properties.</p></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"12 ","pages":"Article 100458"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667142524001003/pdfft?md5=f8eae25ca12cd581fda2c73d4b159ce9&pid=1-s2.0-S2667142524001003-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141235414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preventive and therapeutic effects of ginger on bowel disease: A review of clinical trials","authors":"Lemlem Gebremariam Aregawi ,&nbsp;Teferi Gebru Gebremeskel ,&nbsp;Csiki Zoltan","doi":"10.1016/j.prmcm.2024.100457","DOIUrl":"https://doi.org/10.1016/j.prmcm.2024.100457","url":null,"abstract":"<div><h3>Introduction</h3><p>Ginger has been integrated into various cultural traditions, including traditional Chinese medicine (TCM), where it is highly valued for its preventive and therapeutic efficacy. In traditional Chinese medicine (TCM), ginger is renowned for its ability to support digestive function by stimulating digestive juices, promoting gastric motility, and relieving gastrointestinal discomfort. This systematic review aimed to summarize ginger's preventive and therapeutic effects on bowel disorders and to update the current developments.</p></div><div><h3>Methods</h3><p>Clinical trials published in English were searched in PubMed, Scopus, EMBASE, Web of Science and Clinical Trials databases with keywords from inception to August 2023. The search protocol was performed under the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines and registered in PROSPERO with registration number CRD42022378544. Due to the small sample size and the heterogeneity of studies, a narrative synthesis without meta-analysis is reported.</p></div><div><h3>Results</h3><p>In the current review, evidence of ginger's effect on bowel disorders is reported. A daily dose of 2000 mg of ginger is beneficial for reducing inflammation, dyspepsia, colorectal cancer and ulceration in the digestive tract of patients with IBS and IBD. Because of the heterogeneity and limited number of studies, the results may not be as powerful as finding significant results.</p></div><div><h3>Discussion</h3><p>Despite the small number of studies and the large heterogeneity, the majority of the studies have shown the Chinese traditional medicine, ginger's effect on bowel disorders. However, due to the limited number of studies and some inconsistencies, more controlled clinical trials with different dosages and duration are needed to obtain a firm conclusion.</p></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"12 ","pages":"Article 100457"},"PeriodicalIF":0.0,"publicationDate":"2024-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266714252400099X/pdfft?md5=3b72f426bc1c83f4f146457f04565248&pid=1-s2.0-S266714252400099X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141444217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gypsum alleviates pneumonia via the gut–lung axis by mediating ILC2 compartmental migration","authors":"Ziming Zhuang ,&nbsp;Huiqing Zhu ,&nbsp;Jing Xu ,&nbsp;Lizhen Lin ,&nbsp;Feilong Chen ,&nbsp;Cuiping Jiang ,&nbsp;Qingfa Tang","doi":"10.1016/j.prmcm.2024.100450","DOIUrl":"https://doi.org/10.1016/j.prmcm.2024.100450","url":null,"abstract":"<div><h3>Introduction</h3><p>Bacterial pneumonia is a common lower respiratory tract infectious disease. Gypsum, a type of calcium sulfate mineral, primarily consists of calcium sulfate and contains trace amounts of other metallic elements. In traditional Chinese medicine, gypsum has been widely applied, possessing effects such as heat-clearing, detoxification, cooling blood, arresting bleeding, reducing swelling, and alleviating pain. The purpose of this study was to investigate the mechanism of gypsum inhibition of <em>Streptococcus pneumoniae</em> -induced pneumonia by mediating interregional migration of ILC2 through the gut-lung axis.</p></div><div><h3>Methods</h3><p>Normal pneumonia model was induced by <em>Streptococcus pneumoniae</em>, and pseudo-sterile mouse model was established using broad-spectrum antibiotics. The influence of gypsum on the intestinal flora was analyzed using 16S rDNA. Flow cytometry was used to analyze the typing and content of ILC2 in mouse mesenteric lymph nodes and lung tissues. The expression levels of inflammatory cytokines and specific targets associated with immune migration were assessed using ELISA, RT-qPCR, and western blotting methods. And the effects of gypsum on mucosal barrier using IHC.</p></div><div><h3>Results</h3><p>Gypsum effectively alleviates pulmonary inflammation in mice with pneumonia. Gypsum restores the gut microbiota in mice with <em>Streptococcus pneumoniae</em> and gypsum can regulate the expression of miR-155, miR-146a, IL-25, and S1P, promoting the migration of intestinal ILC2s to the lungs. Finally promotes type 2 immunity, alleviating pneumonia and restore lung mucosal barrier.</p></div><div><h3>Discussion</h3><p>Our study contributes to the understanding of gypsum's function in treating infectious pulmonary conditions. Its mechanism involves remedying gut dysbiosis and initiating ILC2 migration, culminating in decreased lung inflammation and enhanced mucosal immunity in the lungs.</p></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"11 ","pages":"Article 100450"},"PeriodicalIF":0.0,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667142524000927/pdfft?md5=82dfc69e90bcdb9a17ea18bd381f542c&pid=1-s2.0-S2667142524000927-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141097403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacological significance of Catharanthus roseus in cancer management: A review","authors":"Siddharth Goswami ,&nbsp;Amena Ali ,&nbsp;Madhulika Esther Prasad ,&nbsp;Pallavi Singh","doi":"10.1016/j.prmcm.2024.100444","DOIUrl":"https://doi.org/10.1016/j.prmcm.2024.100444","url":null,"abstract":"<div><h3>Introduction</h3><p><em>Catharanthus roseus</em>, commonly known as Vinca Rosea or Madagascar periwinkle, is a significant plant species within the Apocynaceae family, known for its diverse medicinal properties and ornamental attributes, long embraced by Chinese traditional medicine practices.</p></div><div><h3>Methodology</h3><p>Electronic records of papers published in various databases like Scopus, Pubmed, and Google scholar were searched from 2011 onwards and compiled to give a comprehensive overview of the pharmacological significance of <em>C. roseus</em> in Cancer management. This paper provides a comprehensive overview of traditional uses and pharmacological importance of various alkaloids obtained from <em>C. roseus</em> against Cancer and Diabetes mellitus.</p></div><div><h3>Results</h3><p>The alkaloids derived from <em>C. roseus</em> exhibit a wide range of medicinal importance, including antihypertensive, antimicrobial, anti-inflammatory, and anticancer properties. Specifically, Vinblastine and Vincristine, derived from <em>C. roseus</em>, have shown significant efficacy in the treatment of various cancers, including Hodgkin's lymphoma and leukemia, which along with vindesine and vinorelbine are known anti-tumor drugs derived from Chinese traditional medicine. Treatment of inflammations, skin conditions, excretions, respiratory symptoms and elevated blood sugar levels are other uses of <em>C. roseus</em> in Chinese traditional medicine. This paper covers strategies for enhancement of Alkaloids production from <em>C. roseus</em> and highlights their drug delivery systems.</p></div><div><h3>Discussion</h3><p>This paper elucidates various important alkaloids obtained from <em>C. roseus</em> and their biological role. Further, it highlights the signaling pathways effected by Vinca alkaloids found in <em>C. roseus</em> and provides in-depth insights on MiRNA activity and nuclear pathways of Cancer.</p></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"11 ","pages":"Article 100444"},"PeriodicalIF":0.0,"publicationDate":"2024-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667142524000873/pdfft?md5=87631f86b4ee084bdac8d541ffee3fa2&pid=1-s2.0-S2667142524000873-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141078145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comprehensive review on the molecular mechanism of Ginkgo biloba Linn. activity in various metabolic syndromes","authors":"Aditi Gupta ,&nbsp;Neeraj Patel ,&nbsp;Devyani Rajput ,&nbsp;Umesh Kumar Patil","doi":"10.1016/j.prmcm.2024.100446","DOIUrl":"10.1016/j.prmcm.2024.100446","url":null,"abstract":"<div><h3>Introduction</h3><p>In this communication the focus is on the summarization of the complex molecular pathways that <em>Ginkgo biloba</em> Linn<em>.</em> utilizes to treat metabolic syndromes, a major international health concern marked by interrelated risk factors like obesity, insulin resistance, dyslipidaemia, and hypertension.</p></div><div><h3>Method</h3><p>Several databases, including the Web of Science, Google Scholar, PubMed, ScienceDirect, Scopus, and PubChem, were used while literature review was conducted. The use of suitable keywords like mechanism of <em>Ginkgo biloba</em>, pharmacological activities of medicinal plants, herbal remedies in metabolic syndromes etc. was made. It was attempted that all the English language articles published between 1980 and 2023 were referred.</p></div><div><h3>Results</h3><p>Numerous molecular mechanisms contribute to the development of various metabolic syndromes and their risk factors. These mechanisms include insulin resistance, chronic low-grade inflammation, increased oxidative stress, dysregulation of lipid metabolism, impaired mitochondrial function, and others. This review summarizes the ways in which <em>Gingko biloba</em>, through modification of ROS formation, blocking the activation of NADPH oxidases, modifying the expression of antioxidant enzymes, downregulating MAPKs and AP-1, increasing cAMP, deactivating Stat5, activating the AMPK signalling pathway, influencing Stat3/JAK2, NF-κB, Nrf-2, mTOR, HGF/c-Met, Wnt/β-catenin, and BMP signalling pathways, modifying the mitochondrial transmembrane potential, etc., can alleviate disorders related to metabolic dysfunction.</p></div><div><h3>Discussion</h3><p>The therapeutic properties of <em>Ginkgo biloba Linn.</em> and its constituents, including its anti-inflammatory, antioxidant, anti-apoptotic, and apoptotic activities, have drawn attention in recent years. In response to the growing public demand for novel therapeutics, prospective novel medicines may be produced by comprehending their molecular mechanisms and signalling networks.</p></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"11 ","pages":"Article 100446"},"PeriodicalIF":0.0,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667142524000897/pdfft?md5=21edfb153e64beb17342c6f750b359c4&pid=1-s2.0-S2667142524000897-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141031569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The protective effects of young pomelo fruits extract against acute hyperlipidemia and high-fat diet-induced obese mice","authors":"Lac-Thuy Nguyen-Huu ,&nbsp;Van Dat Truong ,&nbsp;Minh-Nhut Truong ,&nbsp;Thanh Ha Nguyen ,&nbsp;Ngoc Phuc Nguyen ,&nbsp;Harvey Tran ,&nbsp;Ngoc Trung Nguyen ,&nbsp;Linh Tu Vo ,&nbsp;Minh-Tri Le ,&nbsp;Huynh Nhu Mai","doi":"10.1016/j.prmcm.2024.100438","DOIUrl":"https://doi.org/10.1016/j.prmcm.2024.100438","url":null,"abstract":"<div><h3>Introduction</h3><p>Pomelo (柚 in Mandarin) (<em>Citrus grandis</em> L. Osbeck), a long-used fruit in Asia and China, is commonly used in traditional Chinese medicine. Pomelo is also a culturally significant fruit tree in Vietnam, renowned for its culinary and medicinal value. Young pomelo fruits possess high levels of flavonoids, but their research significance remains limited. Due to its relatively unknown potential, young pomelo is usually discarded during gardening maintenance leading to waste. This study aims to determine the naringin content and investigate the ameliorative effect on lipid profile of young pomelo extracts.</p></div><div><h3>Methods</h3><p>Two mouse models of hyperlipidemia, specifically tyloxapol and a high-fat diet (HFD) model, were utilized to assess the effects of young pomelo extracts. Tyloxapol decreases the clearance of lipoprotein and leads to acute endogenous hyperlipidemia, while a high fat diet causes obesity among mice. The hypolipidemic effect of young pomelo extract was assessed through the level of serum triglyceride (TG), total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-c), and high-density lipoprotein-cholesterol (HDL-c), while its ameliorative effect was assessed through physical changes of mice and histological changes of their livers.</p></div><div><h3>Results</h3><p>In the tyloxapol model, the naringin-rich young pomelo extracts exhibited promising effects in the treatment of hyperlipidemia. Notably, they significantly reduced total cholesterol, triglycerides, and LDL-c levels while elevating HDL-c levels. In the HFD model, the young pomelo extracts demonstrated similar effects on the biochemical lipid profiles. Moreover, the young pomelo extracts possess a protective effect against HFD-induced hepatosteatosis and hepatic necroinflammation. These findings align with existing literature, highlighting the potential utilization of young pomelo fruits.</p></div><div><h3>Discussion</h3><p>The findings have significant implications for the development of novel therapeutic approaches targeting obesity and related metabolic disorders. Furthermore, the study contributes to promoting sustainable agriculture practices by emphasizing the utilization of young pomelo fruits that would otherwise go to waste. Overall, this study provides valuable insights into establishing a high-fat diet-induced obesity model, tyloxapol-induced hyperlipidemia and demonstrates the potential of young pomelo as a rich source of naringin.</p></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"11 ","pages":"Article 100438"},"PeriodicalIF":0.0,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667142524000812/pdfft?md5=603dde8e929c5e70f06af449cd9c21bf&pid=1-s2.0-S2667142524000812-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141067071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amelioration of gastric ulcer using a hydro-alcoholic extract of Mangifera indica in Sprague Dawley rats by prevention of muco-oxidative stress","authors":"Nazma Khan ,&nbsp;Mohammad Khushtar ,&nbsp;Md Azizur Rahman ,&nbsp;Md Kaish ,&nbsp;Mohd Ajmal","doi":"10.1016/j.prmcm.2024.100442","DOIUrl":"10.1016/j.prmcm.2024.100442","url":null,"abstract":"<div><h3>Background</h3><p>Gastric ulcer is a significant global public health concern that can result in severe complications such as gastro-intestinal bleeding, perforations, gastro-intestinal obstruction and cancer. Mangifera indica seed kernel, a traditional Chinese medicine, is widely available and used in China. The current study was aimed to determine gastro-protective effect of Mangifera indica kernel extract in preventing gastric ulcer in rats.</p></div><div><h3>Methods</h3><p>SD rats were divided into six groups. Each group consisted of five rats. Group-I received 1 ml/kg/day p.o. of 1 % carboxy methylcellulose. Group-II received indomethacin (20 mg/kg/day, p.o.). Group-III received Mangifera indica kernel extract (500 mg/kg/day, p.o.). Group-IV received the extract (1000 mg/kg/day, p.o.). Group-V received 50 mg/kg/day ranitidine. Group-VI (per se) received the extract (1000 mg/kg/day, p.o.). The ulcer index, mucus barrier, and histopathology were calculated. After homogenization of gastric tissue in buffer, anti-oxidant enzyme potency was also evaluated.</p></div><div><h3>Results</h3><p>Mangifera indica kernel extract significantly (<em>p</em> &lt; 0.01) and dose-dependently increased mucus, superoxide dismutase, and catalase levels while lowered ulcer index and thiobarbituric acid reactive substances in comparison to ulcer control group-II. According to histopathological data, indomethacin medication led to gastric ulcers whereas Mangifera indica kernel extract protected from gastric ulcer by prevention of indomethacin-induced muco-oxidative stress. Mangifera indica 1000 mg/kg/day in group-IV had ulcer prevention potency comparable to ranitidine 50 mg/kg/day in group-V.</p></div><div><h3>Discussion</h3><p>Thus, Mangifera indica extract possesses promising effect on amelioration of gastric ulcer and protects from gastric ulcer by prevention of indomethacin-induced muco-oxidative stress, re-inforcing the gastric mucosa, and reducing the secretion of gastric acid.</p></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"11 ","pages":"Article 100442"},"PeriodicalIF":0.0,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266714252400085X/pdfft?md5=9519b3e2b8bdcc4133f8a006c4516848&pid=1-s2.0-S266714252400085X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141027636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amla (Emblica officinalis) alleviates doxorubicin-induced cardiotoxicity and nephrotoxicity in rats","authors":"Mandeep Kumar Arora ,&nbsp;Mary Singh ,&nbsp;Ritu Tomar ,&nbsp;Lakhveer Singh ,&nbsp;Ashok Jangra","doi":"10.1016/j.prmcm.2024.100443","DOIUrl":"https://doi.org/10.1016/j.prmcm.2024.100443","url":null,"abstract":"<div><h3>Introduction</h3><p>Doxorubicin (DOX) is a widely used anticancer drug known for its significant cardiotoxic and nephrotoxic effects. Seeking remedies to mitigate these adverse effects is crucial. This study investigates the potential of <em>Emblica officinalis</em> (Amla) extract, a prominent component in Chinese and Indian traditional medicine systems, in alleviating DOX-induced cardiotoxicity and nephrotoxicity.</p></div><div><h3>Methods</h3><p>DOX (20 mg/kg <em>i.p.</em>, once) was given to rats to cause acute cardiotoxicity and nephrotoxicity. Rats received 16 similar and cumulative doses of DOX (1.25 mg/kg, <em>i.p.</em>) on alternate days for chronic cardiotoxicity and nephrotoxicity. Biochemical and histological evaluations were done to confirm the onset of cardiotoxicity and nephrotoxicity.</p></div><div><h3>Results</h3><p>The cardioprotective and nephroprotective effects of Amla extract (AE) (150 mg/kg <em>p.o.</em> and 300 mg/kg p.o) were evaluated in comparison to Vitamin E (25 mg/kg <em>p.o.</em>). The treatment with AE (300 mg/kg/day, <em>p.o.</em>) considerably prevented DOX-induced cardiotoxicity, nephrotoxicity, and oxidative stress by positively altering the integrity of glomeruli, restoring the tissue GSH and decreasing serum TBARS. AE (300 mg/kg) was found to be more cardioprotective and nephroprotective than Vitamin E (25 mg/kg <em>p.o.</em>).</p></div><div><h3>Discussion</h3><p>It may be concluded that the induction of cardiotoxicity and nephrotoxicity in rats may be due to DOX-induced oxidative stress, and chronic treatment with AE (300 mg/kg) is an effective way to alleviate the cardiotoxic and nephrotoxic adverse effects of DOX in rats. Moreover, given Amla's historical and contemporary significance in Chinese and Indian traditional medicine systems, its potential therapeutic role merits further exploration in clinical settings.</p></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"11 ","pages":"Article 100443"},"PeriodicalIF":0.0,"publicationDate":"2024-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667142524000861/pdfft?md5=2a5a08a56b9e9c7ab8c5f74eedb59dfb&pid=1-s2.0-S2667142524000861-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140951180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}