Pharmacological Research - Modern Chinese Medicine最新文献

{"title":"Identifying active substances of Huangqin Decoction regulating intestinal epithelial barrier dysfunction by mass spectrometry networking and multiscale models","authors":"Juntao Wang ,&nbsp;Yeting Zhou ,&nbsp;Xutao Ge ,&nbsp;Miao Zhu ,&nbsp;Baiping Ma ,&nbsp;Zheng Li ,&nbsp;Yi Wang","doi":"10.1016/j.prmcm.2026.100755","DOIUrl":"10.1016/j.prmcm.2026.100755","url":null,"abstract":"<div><h3>Introduction</h3><div>Huangqin decoction (HQD) is a traditional Chinese medicine prescription recorded in the \"Shang Han Lun\", a decoction composed of huangqin, chishao, gancao and dazao, which has been widely used to relieve symptoms of gastrointestinal diseases, such as ulcerative colitis (UC) and typhoid fever. However, its active components is yet to be clarified.</div></div><div><h3>Methods</h3><div>The chemical composition of HQD was analyzed using liquid chromatography-tandem mass spectrometry (LC-MS/MS), followed by network pharmacology prediction. A colonic cell line and mouse colonic organoid inflammation model were established to observe the effects of HQD and its components on inflammatory factor expression and intestinal barrier function. The efficacy of the aqueous fraction of HQD (HQD-far-A) was further validated in a zebrafish enteritis model by assessing intestinal oxidative stress levels, neutrophil aggregation levels, and goblet cell counts.</div></div><div><h3>Results</h3><div>In the Caco-2 cell inflammation model, HQD and its individual components all reduced the pharmacological effects of elevated inflammatory factors. Treatment with HQD-fra-A significantly protected the intestinal epithelial barrier, including tight junction proteins ZO-1 and Occludin, and this effect was validated in a DSS-induced intestinal organoid inflammation model. In vitro experiments demonstrated that HQD-fra-A reduced neutrophil aggregation and intestinal oxidative stress caused by intestinal inflammation in zebrafish, mitigated intestinal injury, and protected goblet cells to maintain the intestinal barrier.</div></div><div><h3>Discussion</h3><div>HQD has been validated as an effective treatment for colon inflammation by protecting the intestinal barrier. The multi-scale model for drug efficacy validation provides a solid foundation and new insights for advancing drug efficacy evaluations in future research.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"18 ","pages":"Article 100755"},"PeriodicalIF":0.0,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145977799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research progress of traditional Chinese medicine syndrome differentiation in prevention and treatment of hepatic encephalopathy","authors":"Zidong Zhang ,&nbsp;Haodong Bai ,&nbsp;Jiao Zhou ,&nbsp;Desen Ke ,&nbsp;Qiuhong Wang ,&nbsp;Haixue Kuang","doi":"10.1016/j.prmcm.2026.100756","DOIUrl":"10.1016/j.prmcm.2026.100756","url":null,"abstract":"<div><h3>Introduction</h3><div>Hepatic encephalopathy (HE) is a neuropsychiatric syndrome caused by liver dysfunction and metabolic disturbances, presenting with consciousness disorders, behavioral abnormalities, and coma. Despite advances in modern medicine, effective prevention and management remain challenging. Traditional Chinese medicine (TCM) has shown promise in HE treatment through individualized syndrome differentiation and holistic therapeutic strategies.</div></div><div><h3>Methods</h3><div>A comprehensive literature search was conducted in CNKI, Wanfang Data, PubMed, and Google Scholar for studies published from 2005 to 2025. Search terms included combinations of <em>“hepatic encephalopathy,” “traditional Chinese medicine,” “syndrome differentiation,”</em> and <em>“mechanism of action.”</em> After removing duplicates and screening titles, abstracts, and full texts, studies reporting TCM interventions, syndrome differentiation, or mechanisms of HE treatment were included.</div></div><div><h3>Results</h3><div>Analysis revealed that TCM syndrome differentiation for HE predominantly involves phlegm-dampness, fire-toxin, liver-kidney deficiency, and qi-yin deficiency. Core therapeutic strategies include TCM compound decoctions, Chinese herbal enemas, and acupuncture. These interventions demonstrate efficacy in improving neurological symptoms, reducing inflammation and oxidative stress, and modulating gut microbiota.</div></div><div><h3>Discussion</h3><div>TCM offers a holistic, multi-target, and multi-pathway approach for HE management. Syndrome differentiation provides a theoretical basis for personalized therapy, while recent mechanistic studies suggest TCM’s role in modulating the gut–liver–brain axis and neuroinflammation. Standardizing syndrome classifications and integrating multi-omics approaches may further enhance the precision and modernization of TCM-based HE therapies.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"18 ","pages":"Article 100756"},"PeriodicalIF":0.0,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146187332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-proliferative activity of Delphinium denudatum wall. ex Hook.f. & Thomson on U251 MG Glioblastoma Cells","authors":"Amit Man Joshi ,&nbsp;Sagar Atri ,&nbsp;Ram Adhar Yadav ,&nbsp;Santosh Kumar Thakur ,&nbsp;Mithilesh Sah ,&nbsp;Sirjana Shrestha ,&nbsp;Aftab Alam Shah ,&nbsp;Mukesh Kumar Yadav","doi":"10.1016/j.prmcm.2026.100753","DOIUrl":"10.1016/j.prmcm.2026.100753","url":null,"abstract":"<div><h3>Background</h3><div><em>Delphinium denudatum</em> Wall. ex Hook.f. &amp; Thomson (<em>D. denudatum</em>), a perennial herb from the Ranunculaceae family, contains diterpenoid alkaloids with reported bioactivities. While certain <em>Delphinium</em> species are utilized in Chinese folk medicine for analgesic effects, specific documentation for <em>D. denudatum</em> in traditional Chinese medicine is limited. This study evaluates the anti-proliferative effects of its methanolic root extract (DDE) on the U251 MG glioblastoma cell line.</div></div><div><h3>Materials and methods</h3><div>U251 MG cells were treated with various concentrations of DDE and assessed for viability using the Cell Counting Kit-8 (CCK-8) assay. Fluorouracil (50 µg/mL) served as the positive control. The percentage of inhibition and IC₅₀ values were calculated from dose–response curves to evaluate the cytotoxic potential of the extract.</div></div><div><h3>Results</h3><div>DDE demonstrated a dose-dependent inhibition of U251 MG cell proliferation, peaking at ∼60% inhibition at 50 µg/mL, with an IC₅₀ of 43.75 µg/mL. Higher concentrations exhibited reduced inhibition, suggesting a biphasic response. These findings indicate selective cytotoxicity and therapeutic promise of DDE in targeting glioblastoma cells.</div></div><div><h3>Discussion</h3><div>These findings provide preliminary evidence of DDE's cytotoxic potential against glioblastoma cells, supporting further exploration of its bioactive constituents, such as diterpenoid alkaloids, for anti-cancer applications.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"18 ","pages":"Article 100753"},"PeriodicalIF":0.0,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145977883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phyllanthus amarus as a multifunctional medicinal herb: Bioactive compounds, mechanisms, and clinical perspectives","authors":"Md Asaduzzaman ,&nbsp;Lutfun Nahar ,&nbsp;Mohammad Shahangir Biswas ,&nbsp;Munna Kumar Podder ,&nbsp;Md Matiar Rahman","doi":"10.1016/j.prmcm.2026.100752","DOIUrl":"10.1016/j.prmcm.2026.100752","url":null,"abstract":"<div><h3>Introduction</h3><div><em>Phyllanthus amarus</em> Schumach. &amp; Thonn., commonly known in Traditional Chinese Medicine (TCM as Yexiazhu (叶下珠, Yè xià zhū), is a widely used medicinal herb in Asian, African, and South American traditional systems. In TCM practice, Yexiazhu is traditionally prescribed for heat-clearing and detoxification, particularly in the management of liver-and kidney-related disorders, viral infections, and inflammatory conditions. Its rich phytochemical composition, including lignans, flavonoids, and tannins, has prompted increasing scientific interest in validating its traditional therapeutic applications.</div></div><div><h3>Materials and methods</h3><div>This review critically evaluates literature published between 1977 and 2025, encompassing classical TCM texts, ethnomedicinal reports, and peer-reviewed experimental studies. Major scientific databases were surveyed to collect data on phytochemical constituents, pharmacological activities, molecular mechanisms, toxicological profiles, and available clinical evidence related to <em>P. amarus</em> and Yexiazhu-based preparations.</div></div><div><h3>Results</h3><div>Pharmacological studies indicate that <em>P. amarus</em> exhibits hepatoprotective, antidiabetic, antimicrobial, antioxidant, antiviral, anti-inflammatory, and nephroprotective activities. These effects are primarily attributed to bioactive compounds such as phyllanthin, hypophyllanthin, geraniin, corilagin, and quercetin. Commonly used TCM preparations, including aqueous decoctions and granule formulations of Yexiazhu, demonstrate therapeutic potential through modulation of oxidative stress, inflammatory signaling pathways, viral replication, and metabolic regulation. Despite strong experimental support from in vitro and in vivo models, clinical findings remain limited, heterogeneous, and occasionally inconsistent, particularly for hepatitis B and metabolic disorders.</div></div><div><h3>Discussion</h3><div>Collectively, <em>P. amarus</em> (Yexiazhu) represents a multifunctional medicinal herb with substantial experimental evidence supporting its traditional use in TCM and other medical systems. However, challenges related to species differentiation, phytochemical standardization, formulation variability, and limited high-quality clinical trials restrict its translation into modern evidence-based medicine. Future research should focus on standardized Chinese preparations, mechanistic validation, and rigorously designed clinical studies to clarify its therapeutic efficacy and safety.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"18 ","pages":"Article 100752"},"PeriodicalIF":0.0,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145977885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Echinacea-derived alkylamides as complementary immunomodulators: Potential for integration with synthetic immunosuppressive therapies","authors":"Fatemeh Ahmadi ,&nbsp;Ha Truong Nguyen ,&nbsp;Zahra Ahmadi","doi":"10.1016/j.prmcm.2026.100754","DOIUrl":"10.1016/j.prmcm.2026.100754","url":null,"abstract":"<div><h3>Introduction</h3><div>The escalating incidence of autoimmune and inflammatory disorders has intensified reliance on synthetic immunosuppressants, yet long-term safety issues and incomplete therapeutic responses persist. Concurrently, echinacea (紫锥菊, Zǐ Zhuī Jú) extracts rich in alkylamides show promising complementary immunoregulatory activity via cannabinoid receptor 2 (CB₂) engagement and toll-like receptor 4 (TLR4) modulation. In Traditional Chinese Medicine, echinacea is classified as a medicinal herb with a wide applications in treating wind-heat common cold, fever, cough, and sore throat.</div></div><div><h3>Methods</h3><div>This review integrates current pharmacodynamic and pharmacokinetic evidence on (i) corticosteroids, DMARDs, biologics, and JAK inhibitors, and (ii) echinacea-derived alkylamides and caffeic acid derivatives, to identify synergistic mechanisms relevant to integrative immunomodulation. We synthesised data from peer-reviewed articles retrieved through Web of Science, PubMed, and Scopus. Emphasis was placed on receptor-binding assays, in vivo efficacy models, and Phase I–III clinical trials.</div></div><div><h3>Results</h3><div>Synthetic agents chiefly exert single-target or pathway-restricted actions, e.g., glucocorticoid receptor transactivation, JAK–STAT blockade, yielding rapid symptom control but cumulative adverse events. By contrast, echinacea alkylamides demonstrate multi-target behaviour: nanomolar-affinity CB₂ activation dampens TNF-α and IL-6, whereas partial TLR4 antagonism re-balances Th1/Th2 cytokine bias, potentially complementing conventional immunosuppression. Integrating phytotherapeutics with conventional immunosuppressants may optimize efficacy–safety ratios through dose-sparing effects and enhanced therapeutic windows. However, heterogeneity in echinacea chemotypes demands rigorous standardization and head-to-head clinical trials evaluating combination therapies.</div></div><div><h3>Discussion</h3><div>The orthogonal engagement of CB₂ and TLR4 pathways by alkylamides complements the single-target mechanisms of corticosteroids, calcineurin inhibitors, and JAK inhibitors, enabling additive anti-inflammatory effects and potential dose-sparing strategies. This review positions echinacea as a rational adjuvant platform for next-generation complementary immunomodulation strategies within the framework of Traditional Chinese Medicine, supporting the development of personalized integrative approaches to immune disorders. Future research should exploit systems-biology-guided formulation to harness additive CB₂–TLR4 crosstalk in integrative treatment protocols.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"18 ","pages":"Article 100754"},"PeriodicalIF":0.0,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145939175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can Arthrospira (Spirulina) sp. be used to protect the kidneys and prevent hypertension? a systematic review and meta-analysis of preclinical studies","authors":"Gabrielly Hilário da Silva ,&nbsp;Sabrina Swan Souza da Silva ,&nbsp;Ana Lúcia Figueiredo Porto ,&nbsp;Raquel Pedrosa Bezerra","doi":"10.1016/j.prmcm.2026.100751","DOIUrl":"10.1016/j.prmcm.2026.100751","url":null,"abstract":"<div><h3>Introduction</h3><div>In Traditional Chinese Medicine (TCM), natural products such as <em>Spirulina</em> have been valued for centuries for their ability to regulate blood pressure and support organ function, including renal health. <em>Arthrospira</em> (<em>Spirulina</em>) sp., a blue-green cyanobacterium recognized by the United Nations as a \"superfood of the future,\" is rich in phycocyanin, a pigment with emerging nephroprotective potential. This review evaluates the effects of <em>Spirulina</em> or phycocyanin, alone or in combination with other bioactives, on biomarkers of kidney function.</div></div><div><h3>Methods</h3><div>Systematic searches of databases like MEDLINE, Web of Science, LILACS, ScienceDirect, and CENTRAL between 2011 and 2024 are used to identify relevant studies for systematic reviews. The random-effect and inverse variance models were applied to verify data and perform meta-analysis. RoB tool for intervention studies (SYRCLE's RoB tool) and Cochrane Collaboration were used to assess quality and risk of bias.</div></div><div><h3>Results</h3><div>A total of 267 studies were identified, and after screening, 10 were selected for analysis. Despite high heterogeneity across studies, the overall effects were statistically significant. Risk of bias was low across all domains, indicating reliable and robust findings.</div></div><div><h3>Discussion</h3><div>The meta-analysis revealed that <em>Arthrospira</em> (Spirulina) and C-phycocyanin supplementation significantly improved biomarkers of kidney function, reducing serum creatinine, urea, uric acid, and urinary protein levels, as well as lowering systolic blood pressure in preclinical models. Despite consistent trends toward renoprotection and antihypertensive effects, high heterogeneity across studies highlights the need for further research to define optimal doses, treatment durations, and experimental conditions.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"18 ","pages":"Article 100751"},"PeriodicalIF":0.0,"publicationDate":"2026-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145939178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regulatory effect of Pien Tze Huang on the mTreg/mTh17 balance in mice with autoimmune hepatitis","authors":"Linxin Zheng ,&nbsp;Bugao Zhou ,&nbsp;Miaohua Liu ,&nbsp;Yi Xiong ,&nbsp;Xin Zeng ,&nbsp;Kaien Guo ,&nbsp;Duanyong Liu","doi":"10.1016/j.prmcm.2026.100750","DOIUrl":"10.1016/j.prmcm.2026.100750","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the therapeutic efficacy and underlying mechanisms of Pien Tze Huang (PTH) in a murine autoimmune hepatitis (AIH) model through assessment of memory regulatory T cells (mTreg)/memory T helper cell 17 (mTh17) cell equilibrium and glycolytic metabolism.</div></div><div><h3>Methods</h3><div>AIH was induced through intravenous concanavalin A (ConA) administration <em>via</em> tail vein injection with prophylactic PTH treatment over 10 days. Hepatic histopathological alterations were evaluated using H&amp;E staining, while serum transaminase levels were quantified through biochemical analysis. ELISA was employed to determine immunoglobulin concentrations and hepatic tissue levels of interleukin 1β (IL-1β), interleukin 6 (IL-6), interleukin 21 (IL-21), interleukin 10 (IL-10), interleukin 4 (IL-4), tumor necrosis factor α (TNF-α), interferon-gamma (IFN-γ), Immunoglobulin G (IgG), Immunoglobulin A (IgA), Immunoglobulin M (IgM), glycolysis hexokinase 2 (HK2), pyruvate kinase (PK), glucose-6-phosphatase (G6pase), phosphoenolpyruvate carboxykinase (PEPCK), aldolase A (ALDOA), glucokinase (GCK), lactate dehydrogenase A (LDHA). Flow cytometric analysis was performed to quantify Treg, mTreg, Th17, and mTh17 cell populations. Protein expression of glucose transporter protein 1 (Glut1), glucose transporter protein 2 (Glut2), glucose transporter protein 3 (Glut3), glucose transporter protein 4 (Glut4), hypoxia-inducible factor-1α subunit (HIF-1α), signal transducer and activator of transcription 3 (STAT3), phosphorylated signal transducer and activator of transcription 3 (p-STAT3), T-cell transcription factor (T-bet), and retinoic acid receptor-related orphan receptor gamma (RORγt) was analyzed by Western blotting.</div></div><div><h3>Results</h3><div>Relative to the model group, PTH administration significantly ameliorated hepatocellular injury, as evidenced by reduced serum ALT and AST levels, decreased immunoglobulin concentrations, and attenuated hepatic pathological damage (<em>p</em> &lt; 0.05 or <em>p</em> &lt; 0.01). Furthermore, PTH treatment resulted in significant suppression of proinflammatory cytokine expression in murine hepatic tissue (<em>p</em> &lt; 0.05 or <em>p</em> &lt; 0.01). PTH treatment increased the proportions of Treg and mTreg cells while reducing Th17 and mTh17 cell populations (<em>p</em> &lt; 0.05 or <em>p</em> &lt; 0.01). Mechanistic investigations revealed that PTH significantly downregulated the expression of critical glycolytic enzymes and glycolysis-associated proteins in hepatic tissue of AIH model mice (<em>p</em> &lt; 0.05 or <em>p</em> &lt; 0.01).</div></div><div><h3>Conclusions</h3><div>PTH effectively attenuates ConA-induced AIH by modulating the balance of memory Treg/Th17 cells and glycolytic pathways.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"18 ","pages":"Article 100750"},"PeriodicalIF":0.0,"publicationDate":"2026-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145977888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"18 ","pages":"Article 100731"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147047731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"18 ","pages":"Article 100747"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147047743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"18 ","pages":"Article 100732"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147047754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}