Pharmacological Research - Natural Products最新文献

{"title":"Ethnopharmacological survey of local medicinal plants used against schistosomiasis in the Moungo division, littoral region of Cameroon: Cercaricidal, antioxidant and anti-inflammatory activities, cytotoxicity and phytochemical profile of some selected plants","authors":"Dongmo Nguepi Mireille Sylviane ,&nbsp;Ngachou Nebot Floride ,&nbsp;Tincho Marius Belmondo ,&nbsp;Itoe Ubre Sicca ,&nbsp;Noubissi Paul Aime ,&nbsp;Dongmo Nanfack Christelle ,&nbsp;Madjougne Foudjo Domiriane Ornela ,&nbsp;Dize Darline ,&nbsp;Woutouoba Ntieche David ,&nbsp;Wendji Monkam Diana Sandra ,&nbsp;Sofeu Feugaing David Denis ,&nbsp;Ayiseh Rene Bilingwe ,&nbsp;Ghogomu Stephen Mbigha","doi":"10.1016/j.prenap.2026.100492","DOIUrl":"10.1016/j.prenap.2026.100492","url":null,"abstract":"<div><h3>Introduction</h3><div>Schistosomiasis, a neglected tropical disease remains a major public health challenge in sub-Saharan Africa despite widespread use of Praziquantel. In Cameroon, various remedies are traditionally employed for treatment. This study aimed to document such remedies in Loum and Njombe-Penja and evaluate their biological activities against <em>Schistosoma mansoni</em>, with the goal of identifying affordable, community-based antischistosomal agents.</div></div><div><h3>Methods</h3><div>An ethnobotanical survey conducted in Loum and Njombe Penja identified 11 herbalists who reported nine medicinal plants from seven families. The Euphorbiaceae family was most represented, and <em>Euphorbia hirta</em>, <em>Euphorbia prostrata</em>, and <em>Alchornea cordifolia</em> were selected for further analysis. Cercaricidal activity was assessed by exposing <em>S. mansoni</em> cercariae to plant extracts (0.4 – 250 µg/ml). Antioxidant potential was evaluated using DPPH and FRAP assays, while anti-inflammatory activity was measured via albumin denaturation inhibition. Cytotoxicity was tested on LLC-MK2 cells, and phytochemical composition was analyzed using LC-MS and HPLC-UV-ESI-TOF-MS.</div></div><div><h3>Results</h3><div>Methanolic and hexane extracts of <em>E. hirta</em> showed most potent cercaricidal activity with LC₅₀ values of 0.07569 and 0.7994 µg/ml, respectively. <em>E. hirta</em> and <em>A. cordifolia</em> showed strong radical scavenging potential (SC₅₀: 0.3012 – 203.7 µg/ml). A dose-dependent inhibition of albumin denaturation, with plant extracts outperforming Diclofenac at low concentrations was observed. Cytotoxicity assays indicated low toxicity (IC₅₀: 325.7 – 550.8 µg/ml). The Phytochemical screenings identified metabolites as polyphenols, terpenoids, and steroids.</div></div><div><h3>Conclusion</h3><div>These findings suggest that <em>E. hirta, E. prostrata,</em> and <em>A. cordifolia</em> possess cercaricidal, antioxidant, and anti-inflammatory properties. Their rich phytochemical profiles support their potential as effective, low-toxicity antischistosomal remedies suitable for integration into primary health care systems in endemic regions</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"10 ","pages":"Article 100492"},"PeriodicalIF":0.0,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145977481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro anticancer efficacy of Asparagus khorasanensis Extract on MDA-MB-231 Cells for Enhanced Apoptosis Induction in Breast Cancer","authors":"Zahra Montahaei,&nbsp;Mina Ramezani,&nbsp;Zeinab Piravar","doi":"10.1016/j.prenap.2026.100489","DOIUrl":"10.1016/j.prenap.2026.100489","url":null,"abstract":"<div><div>Natural plant-derived compounds are emerging as promising alternatives to conventional chemotherapy due to their selective toxicity and reduced side effects. <em>Asparagus khorasanensis</em>, a traditionally used medicinal plant, remains unexplored for its anticancer potential. This study investigated the cytotoxic and pro-apoptotic effects of a hydroalcoholic extract of <em>A. khorasanensis</em> on triple-negative MDA-MB-231 breast cancer cells, alongside its safety profile in normal human embryonic kidney cells (HEK-293). The extract was chemically characterized by gas chromatography–mass spectrometry (GC-MS), and its cytotoxicity was assessed via MTT assay across various concentrations (3, 6.25, 12.5, 25 and 50 μg/ml) and time points (24 h, 48 h and 72 h). Apoptosis was evaluated by Annexin V-FITC/PI flow cytometry, and expression of apoptosis-related genes (<em>CASPASE-3</em>, <em>CASPASE-8</em>, <em>BAX</em>, <em>BAK</em>, <em>P53</em>, <em>BCL-2</em>) was analyzed by real-time PCR. GC-MS identified Carvacrol and p-thymol as major constituents, reported for the first time in this species. The extract induced significant, concentration- and time-dependent cytotoxicity in MDA-MB-231 cells (IC₅₀ = 24.7 µg/ml at 48 h, p &lt; 0.05), while exhibiting negligible effects on HEK-293 cells. Flow cytometry confirmed increased apoptotic populations, and gene expression analysis revealed upregulation of pro-apoptotic markers and downregulation of <em>BCL-2</em>. These findings provide new evidence for the selective anticancer activity of <em>A. khorasanensis</em> extract and support further investigation of its active constituents as potential complementary therapeutic agents.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"10 ","pages":"Article 100489"},"PeriodicalIF":0.0,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145926627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quercetin and its derivatives as potent inhibitors of PilA protein of Streptococcus sanguinis: An in silico approach to combat infective endocarditis","authors":"Bibhu Prasad Rath ,&nbsp;Aurobinda Rout ,&nbsp;Snehasish Mishra ,&nbsp;Chandana Mohanty","doi":"10.1016/j.prenap.2026.100496","DOIUrl":"10.1016/j.prenap.2026.100496","url":null,"abstract":"<div><div><em>Streptococcus sanguinis</em> (<em>S. sanguinis</em>) is a leading cause of infective endocarditis (IE) that cause a wide range of clinical manifestations including death. It utilizes the PilA protein (a key component of type IV pili) to mediate strong adhesion and biofilm formation in heart tissues. Such biofilms exhibit resistance to traditional antibiotics like penicillin G and vancomycin. The standard treatment with these antibiotics are often ineffective owing to poor biofilm penetration leading to persistent infection and antibiotic resistance. Therefore, targeting PilA offers a potential strategy for disrupting biofilm formation and enhancement of IE treatment. The present <em>in silico</em> study is designed to evaluate Quercetin and its derivatives as a safer and alternative strategy to combat <em>S. sanguinis</em>-mediated biofilm formation. Molecular docking analyses demonstrated that Quercetin (-6.5 kcal/mol) and 8-prenylquercetin (-6.6 kcal/mol) exhibited stronger binding to the PilA protein of <em>S. sanguinis</em> compared to Penicillin G (-6.5 kcal/mol), indicating their superior potential in disrupting biofilm formation. Dynamic simulation further confirmed the stability of these complexes over time, suggesting persistent interaction with the target site. Pharmacokinetic evaluation also revealed favourable absorption, distribution, and metabolic properties, while toxicity prediction showed minimal adverse effects. Overall, the study highlights that Quercetin and its derivatives may serve as promising antibiofilm candidates against <em>S. sanguinis</em>. However, experimental validation through <em>in vitro</em> and <em>in vivo</em> studies is warranted to confirm their biological efficacy and safety.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"10 ","pages":"Article 100496"},"PeriodicalIF":0.0,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145926604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Honey-induced rejuvenation: Exploring anti-aging effects and stem cell proliferation in human dental pulp stem cells","authors":"Mayuri Bapu Chavan ,&nbsp;Ajay Kale ,&nbsp;Avinash Kharat ,&nbsp;Deepak Chandra Joshi ,&nbsp;Payal Pawar ,&nbsp;Ramesh Bhonde ,&nbsp;Diksha Jindal","doi":"10.1016/j.prenap.2026.100493","DOIUrl":"10.1016/j.prenap.2026.100493","url":null,"abstract":"<div><h3>Background</h3><div>Human dental pulp stem cells (hDPSCs) hold significant potential for regenerative therapies because of their capacity to differentiate into multiple cell lineages. However, their application is limited by cellular senescence during expansion in vitro. Honey is an organic product that is known for its pharmacological properties and antioxidant. The effects of honey on anti-aging, proliferation, and cell cycle in human dental pulp stem cells (hDPSCs) have not yet been investigated. This study aimed to explore the impact of honey on cell proliferation and senescence using hDPSC as a platform for screening.</div></div><div><h3>Methods</h3><div>DPSCs were treated with honey-supplemented cell culture media to investigate its effects on cellular senescence and proliferation. DPSC proliferation was measured using the MTT assay and cell cycle analyses. Beta-galactosidase senescence assay was used to detect senescence.</div></div><div><h3>Results</h3><div>Honey-supplemented culture media increased DPSC proliferation significantly, as evidenced by MTT assay. Cell cycle analysis indicated an increase in the G2/M phase, preventing DPSCs from entering cell cycle arrest phase. Furthermore, honey at a concentration of 0.5 % reduced the number of senescent-positive cells, as confirmed by beta-galactosidase senescence assay.</div></div><div><h3>Conclusion</h3><div>Our results demonstrate that honey enhances cell proliferation, regulates the cell cycle by preventing DPSCs from cell cycle arrest, and delays senescence in DPSCs. Overall, this study shows that honey is safe, cost-effective, and has anti-senescence activity in hDPSCs.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"10 ","pages":"Article 100493"},"PeriodicalIF":0.0,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145926601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of global research trends in essential oils: A bibliometric study of the top 100 most cited articles in the scopus database","authors":"Baby Gargi ,&nbsp;Pooja Singh ,&nbsp;Sakshi Painuli ,&nbsp;Shabaaz Begum ,&nbsp;Jigisha Anand ,&nbsp;Prabhakar Semwal ,&nbsp;Haroon Khan","doi":"10.1016/j.prenap.2026.100488","DOIUrl":"10.1016/j.prenap.2026.100488","url":null,"abstract":"<div><div>Globally, essential oils (EOs) have been established in the spotlight because of their adaptability and the growing interest of consumers. Citations indeed represent the most significant contributions made in a specific field. With this concern, we performed a bibliometric analysis to describe the 100 most cited articles about plant-derived EOs. The relevant information was retrieved from the Scopus database and scrutinized manually. The selected data was then analyzed and visualized through Microsoft Excel, Bibliometrix and VOSviewer software. A total of 100 documents were reviewed from a total of 48,998 publications. The citation counts of these articles ranged from 541 to 6482. These articles were published in 57 journals among which <em>Phytotherapy Research, Food Chemistry</em> and <em>Journal of Agricultural and Food Chemistry</em> were the most productive journals in terms of number of publications. In the case of contribution of countries and institutions, the <em>USA</em> (n = 12), and <em>Agriculture University of Athens</em> (n = 5) ranked first. The statistical analysis revealed a moderate positive correlation (R² = 0.5137) between the publication year and number. This analysis revealed critical themes, including the biological potential of EOs and their wide-ranging applications in aromatherapy, edible coatings, and food preservation – areas that were consistently highlighted in the leading cited studies. Overall, this study delineates the developments, research dynamics, and emerging trends in EO research, providing a significant reference for future studies.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"10 ","pages":"Article 100488"},"PeriodicalIF":0.0,"publicationDate":"2026-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145926628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of biochanin A in the treatment of diabetes and its complications","authors":"Aminu Mohammed ,&nbsp;Nasir Tajuddeen ,&nbsp;Murtala Bindawa Isah ,&nbsp;Mohammed Auwal Ibrahim","doi":"10.1016/j.prenap.2026.100491","DOIUrl":"10.1016/j.prenap.2026.100491","url":null,"abstract":"<div><div>Biochanin A is a dietary isoflavone with several pharmacological effects, like anticancer, antimicrobial, and antidiabetic properties. Herein, the antidiabetic activities of biochanin A using various diabetes models, including cell line-based, <em>in vivo</em>, and <em>in vitro</em> assays, were reviewed. Relevant articles were sourced from the major scientific databases (Scopus, PubMed, and Google Scholar). The studies included were those that reported the effects of biochanin A on key diabetes markers, such as glucose utilisation and insulin sensitivity, <em>in vitro</em> and <em>in vivo</em> models, as well as in cell-based studies. Collectively, the data revealed that biochanin A has a potential to reduce hyperglycemia, insulin resistance, and diabetes-induced oxidative stress. Such activities were linked, among others, to the activation of Nrf2 and PI3K/Akt pathways, increasing adiponectin level and visfatin expressions as well as inhibitions of NF-κB, GSK3β and serum resistin. With the current available studies, biochanin A showed promising antidiabetic activity in several diabetes models with relatively no adverse side effects, although no study is available to confirm the efficacy in human volunteers. Detailed clinical trials and toxicological studies are warranted to validate the preclinical data.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"10 ","pages":"Article 100491"},"PeriodicalIF":0.0,"publicationDate":"2026-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145926606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Murraya koenigii as a phytotherapeutic agent in breast cancer: A comprehensive review","authors":"Debalina Bose ,&nbsp;Sachin Shetty ,&nbsp;Anushree Udupi ,&nbsp;Kishore Srinivasan","doi":"10.1016/j.prenap.2025.100487","DOIUrl":"10.1016/j.prenap.2025.100487","url":null,"abstract":"<div><div><em>Murraya koenigii</em> (MK), a medicinal plant long esteemed in traditional Asian medicine, is rich in pharmacologically active constituents, particularly carbazole alkaloids (e.g., mahanine, koenimbine, girinimbine), flavonoids (e.g., myricetin, quercetin), and terpenoids. These compounds exert potent anticancer effects, especially against breast cancer, by inducing apoptosis, inhibiting metastasis, and modulating oxidative stress and inflammation. Mahanine has been shown to downregulate CDK4/6 and estrogen receptor-α, while koenimbine activates cytochrome c-mediated intrinsic apoptosis via caspase-9. MK extracts inhibit multiple oncogenic signaling cascades including NF-κB, PI3K/Akt/mTOR, and MAPK, and suppress proteasomal function and ROS-mediated proliferation. <em>In vitro</em> studies report IC₅₀ values as low as 4.5 µM (mahanimbine) and 6.5 µg/mL (silver nanoparticle-formulated MK extract) against MDA-MB-231 breast cancer cells. <em>In vivo</em>, MK administered at 300 mg/kg significantly reduced tumor burden and elevated apoptotic markers in 7,12-dimethylbenz[<em>a</em>]anthracene (DMBA)-induced rodent models. This review highlights MK’s potential as a low-toxicity adjunctive therapy in breast cancer treatment. Future directions include subtype-specific clinical trials, nanocarrier-based delivery systems, and biomarker-driven therapeutic stratification to facilitate clinical translation.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"10 ","pages":"Article 100487"},"PeriodicalIF":0.0,"publicationDate":"2025-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145885074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical and pharmacological potential of mangroves: A comprehensive review on traditional uses and medicinal prospects","authors":"Shital S. Chavan ,&nbsp;Prashant B. Shamkuwar ,&nbsp;Manoj G. Damale","doi":"10.1016/j.prenap.2025.100485","DOIUrl":"10.1016/j.prenap.2025.100485","url":null,"abstract":"<div><h3>Background</h3><div>Mangroves are ecologically significant plants that serve as valuable reservoirs of secondary metabolites with diverse pharmacological applications. Despite their extensive traditional use, limited scientific validation exists for many mangrove species and their bioactive compounds.</div></div><div><h3>Objective</h3><div>The goal of this review is to give a thorough overview of the taxonomy, ethno pharmacology, phytochemical profiles, and pharmacological activity of traditionally used mangroves. It does this by showing how useful they could be as medicine and how much more research has to be done.</div></div><div><h3>Methods</h3><div>A systematic literature review was conducted using databases such as Pub hem, Elsevier, Science Direct, Bentham Science, and other search engines. Relevant studies on the phytochemical constituents, pharmacological activities, and medicinal applications of mangrove species were analysed and synthesized.</div></div><div><h3>Results</h3><div>Mangrove makes a number of substances that are useful for medicine, including as flavonoids, saponins, tannins, alkaloids, phenolic compounds, terpenoids, and steroids. The predominant pharmacological activities reported include antioxidant, antimicrobial, antidiabetic, and antiulcer properties. While several species have demonstrated promising bioactivity, their potential for drug development remains underexplored. Notably, mangrove-derived compounds with antibacterial properties lack extensive formulation-based research, limiting their pharmaceutical applications.</div></div><div><h3>Conclusion</h3><div>There is a great need for thorough research supported by precise clinical and scientific data to guarantee the safety and effective use of these plants, to explore their full medicinal potential and facilitate drug discovery and validate their pharmacological characteristics and toxicity especially since mangroves have high potential for medicinal products and drug discovery to prevent and treat many diseases.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"10 ","pages":"Article 100485"},"PeriodicalIF":0.0,"publicationDate":"2025-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145885059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review on the phytochemicals of Eclipta prostrata and Eclipta alba: Antioxidants and antidiabetic activities","authors":"Nur Nahar Sohe ,&nbsp;John Sushma Nannepaga ,&nbsp;Wan Amir Nizam Wan Ahmad ,&nbsp;Norizah Mhd. Sarbon ,&nbsp;Mannur Ismail Shaik","doi":"10.1016/j.prenap.2025.100483","DOIUrl":"10.1016/j.prenap.2025.100483","url":null,"abstract":"<div><div>Diabetes mellitus, also known as Diabetes, poses a threat to human health by affecting millions worldwide and ranking among the leading causes of mortality and disability. The urgent need for safer, cost-effective natural alternatives to synthetic drugs has sparked a profound interest in medicinal plants with dual antioxidant and antidiabetic properties. <em>Eclipta</em> species, particularly <em>Eclipta prostrata</em> and <em>Eclipta alba</em>, are traditionally recognized in Ayurveda, Traditional Chinese Medicine and folk healing systems for their rich phytochemical composition and diverse pharmacological properties. The whole plant, including leaves, stems and roots, has been shown to contain a variety of secondary metabolites such as flavonoids, phenols, terpenoids, alkaloids, coumarins, polyacetylenes, tannins and others that contribute to various therapeutic activities. These species exhibit potent antioxidant activities through free radical scavenging, thereby reducing oxidative stress. Their antidiabetic effects are primarily linked to the inhibition of carbohydrate-hydrolyzing enzymes (α-amylase and α-glucosidase), modulation of glucose metabolism, and resistance to oxidative damage. Although they exhibit promising medicinal activities in both traditional and modern medicine, comparative studies between species, standardized phytochemical profiling are limited. Therefore, this review, for the first time, summarizes the major phytochemical profiles (mostly flavonoids and phenolic compounds) of <em>E. prostrata</em> and <em>E. alba</em>, particularly the correlations between phytochemical classes and their contributions to antioxidant and antidiabetic activities. The findings highlight the possibilities of <em>E. prostrata</em> and <em>E. alba</em> for developing standardized nutraceuticals and plant-based formulations to mitigate oxidative stress and manage diabetes.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"10 ","pages":"Article 100483"},"PeriodicalIF":0.0,"publicationDate":"2025-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145885058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of anthocyanin consumption on functional connectivity in dementia and type 2 diabetes mellitus","authors":"Aynur Muduroglu Kirmizibekmez ,&nbsp;Alparslan Onder ,&nbsp;Mustafa Yasir Ozdemir ,&nbsp;Onder Yuksel Eryigit ,&nbsp;İhsan Kara","doi":"10.1016/j.prenap.2025.100486","DOIUrl":"10.1016/j.prenap.2025.100486","url":null,"abstract":"<div><div>This study investigates the effects of 12 weeks of anthocyanin consumption on brain function in individuals with Dementia with Type 2 Diabetes Mellitus (T2DM) and Dementia alone. Two groups of individuals: 12 participants with T2DM comorbid with dementia and 31 participants with dementia alone. EEG recordings were collected at baseline, before the start of the study, and after 12 weeks of anthocyanin consumption. During the study period, participants consumed 300 mg of anthocyanins daily. EEG recordings were conducted using a 21-channel gel EEG cap following the 10–20 system at a sampling rate of 500 Hz. EEG signals were divided into seven frequency bands, and the Imaginary Part of Coherence (iCOH) metric, which reduces volume conduction effects, was used to evaluate functional connectivity. Within-group analyses were performed using the Wilcoxon signed-rank test, and between-group comparisons were conducted using the Mann-Whitney U test, both implemented in Python. This study demonstrates that 12 weeks of anthocyanin supplementation positively impacts neural network efficiency and functional connectivity in both the Cognitive Impairment (CI) group and the Type 2 Diabetes Mellitus with Cognitive Impairments (T2DMwCI) group. Significant improvements were observed in iCOH, GE, and LE metrics across delta, theta, beta, and gamma frequency bands, indicating enhanced information processing and potential compensatory mechanisms. These findings highlight the neuroprotective properties of anthocyanins, suggesting their potential to mitigate cognitive decline associated with T2DM and dementia. As a result, it supports the idea that anthocyanins are a potential dietary intervention for mitigating cognitive decline, though further research is needed to validate and expand these results.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"10 ","pages":"Article 100486"},"PeriodicalIF":0.0,"publicationDate":"2025-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145885071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}