Pharmacological Research - Natural Products最新文献_第10页

Curcumin supplementation mitigates renal dysfunction via enhanced glucose metabolism and inflammatory regulation in alloxan-induced diabetic rats 姜黄素补充剂通过增强葡萄糖代谢和炎症调节来减轻四氧嘧啶诱导的糖尿病大鼠的肾功能障碍

Pharmacological Research - Natural Products

Pub Date : 2025-12-15 DOI: 10.1016/j.prenap.2025.100464

Igbayilola Yusuff Dimeji , Saka Waidi Adeoye , Hamidu Lawan Jabba , Ngabea Murtala Audu , Adekola Saheed Ayodeji , Aina Olawale Samson , Agunbiade Mercy Oluwaseyi , Lawal Abdulmujeeb Abodunrin

Diabetic kidney disease (DKD), a major cause of end-stage renal disease, affects 30–40 % of individuals with diabetes, a condition projected to impact 783 million people by 2025. This study investigated the effects of curcumin supplementation on renal function and glucose metabolism in alloxan-induced diabetic male Wistar rats. Forty-five rats (150–200 g) were divided into five groups (n = 9): Group A (Control), Group B (Alloxan only), Group C (Alloxan + Metformin), Group D (Alloxan + Curcumin), and Group E (Curcumin only). Diabetes was induced by alloxan (150 mg/kg, intraperitoneally), and blood glucose levels were monitored after 72 h. Groups C, D, and E received metformin (100 mg/kg) or curcumin (100 mg/kg) daily for 4 weeks. Posttreatment, fasting blood samples were collected to assess blood glucose, insulin, and renal function markers, including serum urea, creatinine, and electrolytes (Na+, K+, Clˉ, and HCO3ˉ). Additionally, glucose metabolic enzymes—hexokinase, fructokinase, and pyruvate kinase—were analysed in liver and muscle tissues. The results revealed that alloxan-induced diabetes significantly elevated the serum urea, creatinine, and electrolytes. Curcumin treatment significantly reduced these markers and corrected electrolyte imbalances. It also increased glucose metabolic enzyme activities, increased GLUT4 protein expression in muscle tissues, and reduced insulin resistance, as indicated by the HOMA-IR scores. These findings suggest that curcumin supplementation improves glucose metabolism, reduces inflammation, and preserves renal function, making it a potential therapeutic approach for diabetic nephropathy and an adjuvant for diabetes treatment.

糖尿病肾病（DKD）是终末期肾病的主要病因，影响着30 - 40% %的糖尿病患者，预计到2025年糖尿病患者将达到7.83亿人。本研究探讨了补充姜黄素对四氧嘧啶诱导的糖尿病雄性Wistar大鼠肾功能和葡萄糖代谢的影响。将45只（150 ~ 200 g）大鼠分为5组（n = 9）：A组（对照组）、B组（单药四氧嘧啶）、C组（单药四氧嘧啶+二甲双胍）、D组（单药四氧嘧啶+姜黄素）、E组（单药姜黄素）。四氧嘧啶（150 mg/kg，腹腔注射）诱导糖尿病，72 h后监测血糖水平。C、D、E组每日给予二甲双胍（100 mg/kg）或姜黄素（100 mg/kg）治疗，连续4周。治疗后，采集空腹血液样本，评估血糖、胰岛素和肾功能指标，包括血清尿素、肌酐和电解质（Na+、K+、Cl - h和HCO3 - h）。此外，葡萄糖代谢酶——己糖激酶、果糖激酶和丙酮酸激酶——在肝脏和肌肉组织中被分析。结果显示，四氧嘧啶诱导的糖尿病显著升高血清尿素、肌酐和电解质。姜黄素治疗显著降低了这些指标并纠正了电解质失衡。HOMA-IR评分显示，它还能提高葡萄糖代谢酶活性，增加肌肉组织中GLUT4蛋白的表达，降低胰岛素抵抗。这些发现表明，补充姜黄素可以改善葡萄糖代谢，减少炎症，并保持肾功能，使其成为糖尿病肾病的潜在治疗方法和糖尿病治疗的辅助手段。

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引用次数: 0

Unlocking new horizons in wound healing therapy: Harnessing the power of nanocarriers beyond traditional therapies 打开伤口愈合治疗的新视野：利用纳米载体超越传统疗法的力量

Pharmacological Research - Natural Products

Pub Date : 2025-12-12 DOI: 10.1016/j.prenap.2025.100460

Sanskriti Sarkar , Amarjitsing Rajput , Amol D. Gholap , Santosh Yele , Shailesh Chalikwar

Wound healing is a complex biological event essential for tissue repair and regeneration. Despite their efficacy, conventional methodologies frequently encounter constraints such as the risk of infection and extended duration of healing. Recent developments have demonstrated the effectiveness of phytoconstituents in the treatment of wound healing because of their anti-inflammatory, antibacterial, and antioxidant properties. However, obstacles such as inadequate bioavailability and stability remain significant concerns. Hence, nanocarriers are considered as a revolutionary paradigm for these phytoconstituents. Nanocarriers possesses the potential to deliver plant bioactive to attain effective amount within therapeutic window for prolong duration. In last decades, researchers and scientists have explored the different nanocarriers like solid lipid nanoparticles, liposomes, nanofibers etc. for efficient delivery of plant bioactive. Nanocarriers have been mainly utilized to entrap the plant bioactive to increase their solubility, penetrability, half life (elimination), bioavailability, pharmacokinetics and therapeutics potential. Moreover, problems associated with nanocarriers such as nanotoxicity, scalability, regulatory aspects and translational gaps are considered as major concern to be overcome for its use. This review delves into the underlying mechanisms of wound healing, the therapeutic functions of various phytoconstituents, and the state-of-the-art nanotechnology-driven strategies that optimize their administration. Furthermore, it addresses clinical trials, regulatory frameworks, and safety considerations associated with nanocarriers in wound management. Thus, recent advances in the nanocarriers systems serve as promising approach for developing efficacious, sustainable, and individualized wound healing interventions.

伤口愈合是一个复杂的生物事件，对组织修复和再生至关重要。尽管传统方法有效，但经常遇到诸如感染风险和愈合时间延长等限制。最近的发展已经证明了植物成分在治疗伤口愈合中的有效性，因为它们具有抗炎、抗菌和抗氧化的特性。然而，诸如生物利用度和稳定性不足等障碍仍然令人担忧。因此，纳米载体被认为是这些植物成分的革命性范例。纳米载体具有将植物生物活性在治疗窗口内达到有效量并延长持续时间的潜力。在过去的几十年里，研究人员和科学家们探索了不同的纳米载体，如固体脂质纳米颗粒、脂质体、纳米纤维等，以有效地输送植物的生物活性。纳米载体主要用于捕获植物的生物活性，以增加其溶解度、渗透性、半衰期（消除）、生物利用度、药代动力学和治疗潜力。此外，与纳米载体相关的问题，如纳米毒性、可扩展性、监管方面和翻译差距被认为是其使用需要克服的主要问题。这篇综述深入探讨了伤口愈合的潜在机制，各种植物成分的治疗功能，以及优化其管理的最先进的纳米技术驱动策略。此外，它还涉及与伤口管理中纳米载体相关的临床试验、监管框架和安全考虑。因此，纳米载体系统的最新进展为开发有效、可持续和个性化的伤口愈合干预措施提供了有希望的方法。

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引用次数: 0

Phytochemical screening and in vitro evaluation of antioxidant, anti-inflammatory, anti-diabetic, anti-microbial activity of Vaccinium griffithianum leaves of ethanol extract 牛痘叶乙醇提取物的植物化学筛选及抗氧化、抗炎、抗糖尿病、抗微生物活性体外评价

Pharmacological Research - Natural Products

Pub Date : 2025-12-11 DOI: 10.1016/j.prenap.2025.100455

Freddy Teilang Nongkhlaw , David Lalremruata , Lamkupar L. Nongbri , Toli Dirchi , Bibhuti Bhusan Kakoti

The study evaluated the phytochemical properties, active polyphenols, the antioxidant, and anti-inflammatory capacity of Vaccinium griffithianum leaves of ethanol extract. Phytochemical analysis revealed the presence of important secondary metabolites. The GC-MS analysis showed the presence of 13 bioactive compounds of which Ethyl α-D-glucopyranoside, dulcitol and 1,2,3,4,5,6-Hexa-O-trimethelsilyl-myo-inositol were the prominent compounds present. The phenolic content was found to be 143.35 ± 0.34 mg of GAE/g. and total flavonoid was found to be 143.35 ± 0.34 mg of GAE/g respectively. The extracts demonstrated high antioxidant activity in, 2,2-diphenyl-1-picrylhydrazyl (DPPH) and H₂O₂ assays which were comparable with butylated hydroxytoluene (BHT) and the scavenging activity was increasing when the concentrations were increased in the extract. The anti-inflammatory potential was established by egg albumin and bovine serum albumin denaturation, anti-diabetic and anti-microbial by inhibitory assay. The results of this study demonstrated that V. griffithianum can be explored as a natural source of anti-inflammatory, antioxidant, anti-diabetic and anti-microbial compounds.

本研究评价了枸杞叶乙醇提取物的植物化学性质、活性多酚、抗氧化和抗炎能力。植物化学分析显示了重要的次生代谢物的存在。GC-MS分析结果显示，其中以乙基α- d -葡萄糖苷、dulcitol和1,2,3,4,5,6-六- o-三甲基硅基肌醇为主要活性成分。其酚类物质含量为143.35 ± 0.34 mg /g。总黄酮含量分别为143.35 ± 0.34 mg /g。在2,2-二苯基-1-picrylhydrazyl （DPPH）和H2O2检测中显示出较高的抗氧化活性，与丁基羟基甲苯（BHT）相当，并且随着提取物浓度的增加，清除活性逐渐增强。通过蛋白蛋白和牛血清白蛋白变性试验，抑菌抑糖和抗糖尿病试验，确定其抗炎作用。本研究结果表明，griffithianum可作为抗炎、抗氧化、抗糖尿病和抗微生物化合物的天然来源。

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引用次数: 0

HPLC analysis and anti-inflammatory, antinociceptive and antidepressant properties of the plant Cynara humilis L. 黄缕草的高效液相色谱分析及抗炎、抗伤、抗抑郁作用。

Pharmacological Research - Natural Products

Pub Date : 2025-12-09 DOI: 10.1016/j.prenap.2025.100452

Mostafa El Khomsi , Meryem Doubi , Anouar Hmamou , Nor El houda Tahiri , Hajar Esserghini , Miloudia Slaoui , Driss Hmouni

Cynara humilis is a species traditionally used in phytotherapy, although is phytochemical profile and biological properties remain insufficiently explored. Phytochemical characterisation was carried out by HPLC-MS analysis. The anti-inflammatory potential of the extracts was evaluated through the carrageenan-induced paw oedema assay in a rat model. The antinociceptive effect was analyzed by measuring abdominal contractions following intraperitoneal injection of acetic acid. In addition, the antidepressant potential was investigated using the forced swimming test. Oral administration of the extracts was performed using doses 200 and 400 mg/kg body weight. The HPLC analysis of leaf and root extracts revealed the presence of eight phenolic compounds in each extract. Assessment of the extracts’ anti-inflammatory properties demonstrated a significant reduction in paw oedema induced by the administration carrageenan (p = 0.000) in rat treated with a dose of 400 mg/kg, six hours after carrageenan injection. The percentages of inhibition observed was 71.42 ± 2.00 % for root extract and 81.42 ± 3.00 % for leaf extract, while that of the anti-inflammatory reference used, diclofenac at a dose of 15 mg/kg, was 86.84 ± 4.00. For the assessment of antinociceptive properties, a significant reduction in the number of acetic acid-induced abdominal contractions was observed in rats (p = 0.000) from 39.33 ± 1.24 in the negative control group to 8.67 ± 1.15 in the group receiving 400 mg/kg leaf extract, and to 12.00 ± 1.00 in the group receiving 400 mg/kg root extract. In comparison, the aspirin-treated group show contractions of 10.33 ± 0.57. Moreover, finding from the antidepressant activity show that the immobility time varies from 47.27 ± 2.53 s in rats administered 400 mg/kg of root to 46.87 ± 5.95 s in those treated with 400 mg/kg of leaf extract, while that of diazepam was 41.86 ± 5.83 s. These results offer a strong foundation for the potential development of plant-based pharmacological agents exhibiting anti-inflammatory, analgesic and antidepressant properties.

金缕草（Cynara humilis）是一种传统上用于植物治疗的植物，尽管其植物化学特征和生物学特性尚未得到充分的研究。采用高效液相色谱-质谱法进行植物化学表征。通过角叉菜胶诱导的大鼠足跖水肿实验，评估了提取物的抗炎潜力。通过测定腹腔注射乙酸后的腹部收缩量来分析其抗疼痛效果。此外，采用强迫游泳试验研究抗抑郁潜能。口服剂量分别为200和400 mg/kg体重。叶和根提取物的高效液相色谱分析显示，每个提取物中存在8种酚类化合物。对提取物抗炎特性的评估表明，在卡拉胶注射后6小时，给药400 mg/kg的大鼠，卡拉胶诱导的足跖水肿显著减少（p = 0.000）。抑制观察到的百分比是71.42 ±2.00  % 81.42根提取物和 ±3.00  %叶提取物,而抗炎的参考使用,双氯芬酸的剂量 15毫克/公斤,86.84 ±4.00 。antinociceptive属性的评价,显著减少醋酸腹部收缩段的数量在大鼠(p = 0.000)从39.33 ±1.24 负对照组8.67 ±1.15 集团获得400 毫克/公斤叶提取物,和12.00 ±1.00 集团获得400 毫克/公斤根提取物。相比之下，阿司匹林治疗组的收缩率为10.33 ± 0.57。此外,发现的抗抑郁活性表明,固定时间从47.27 ±2.53  年代400年老鼠管理 46.87毫克/公斤的根 ±5.95  年代400年那些对待 毫克/公斤的叶子中提取,而安定是41.86 ±5.83  年代。这些结果为开发具有抗炎、镇痛和抗抑郁特性的植物性药物提供了坚实的基础。

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引用次数: 0

Isolation and therapeutic evaluation of schweinfurthin B and F from Nigerian green propolis 尼日利亚绿蜂胶中施威因菌素B和F的分离及疗效评价

Pharmacological Research - Natural Products

Pub Date : 2025-12-09 DOI: 10.1016/j.prenap.2025.100453

Sylvester N. Ugariogu , Ijeoma A. Duru , Ahmed M. Zheoat , Naser F. Al-Tannak , Samya Sh. Alenezi , Eman Y. Santali , Alexander I. Gray , John O. Igoli

Propolis produced by bees has been reported to possess numerous pharmacological properties and applications due to its complex phytochemical composition. Its constituents are reported to vary depending on location, season, region, and mode of extraction. The hexane and ethyl acetate extracts of a green propolis sample from Umudike in Umuahia, Nigeria, were subjected to column chromatography following profiling and dereplication studies, which revealed some phytochemicals such as β-Amyrin, calycosin, schweinfurthins, propolins, and quercetin. The isolates were analysed by NMR and mass spectrometry. The medicinal properties of these compounds were studied in silico. Based on the spectroscopic data, the isolates were identified as Schweinfurthins B and F. The Prediction of Activity Spectra for Substances analysis and the in silico molecular docking results suggest that these compounds could possess anticancer properties due to their binding affinity with Cyclin-dependent kinase (CDK) and human progesterone receptor (PR) proteins, which compare favourably with standard anticancer drugs.

蜂胶由蜜蜂生产，由于其复杂的植物化学成分，已被报道具有许多药理特性和应用。据报道，其成分因地点、季节、地区和提取方式而异。对来自尼日利亚乌穆阿伊亚乌穆代克的绿色蜂胶样品的己烷和乙酸乙酯提取物进行了柱层析分析和重复研究，发现了一些植物化学物质，如β-Amyrin、毛蕊异黄酮、schweinfurthins、蜂胶蛋白和槲皮素。分离物经核磁共振和质谱分析。用硅片研究了这些化合物的药性。物质分析的活性谱预测和硅分子对接结果表明，这些化合物与细胞周期蛋白依赖性激酶（CDK）和人孕酮受体（PR）蛋白的结合亲和力可能具有抗癌特性，与标准抗癌药物相比具有优势。

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引用次数: 0

Antibacterial efficacy and bioactive pigments’ profiling of Arnebia euchroma (Ratanjot): A critically endangered medicinal plant from the Trans-Himalayan region 跨喜马拉雅地区极度濒危药用植物紫檀（Arnebia euchroma, Ratanjot）的抗菌功效及生物活性色素分析

Pharmacological Research - Natural Products

Pub Date : 2025-12-09 DOI: 10.1016/j.prenap.2025.100457

Sunita Devi, Aditi Rana, Kumari Manorma, Pooja Sharma, Subhash Chand, Megha Sharma

This study evaluated the antibacterial efficacy of Arnebia euchroma (Ratanjot): a critically endangered medicinal plant from the Trans-Himalayan region, root extracts prepared using methanol, ethanol, and distilled water against human pathogens, including Enterobacter aerogenes, Proteus sp., Klebsiella pneumoniae, Shigella sp., Escherichia coli ATCC 10418, and Salmonella typhi NCTC 786. The antibacterial activity was assessed using the agar well diffusion and minimum inhibitory concentration assays. Results revealed that the distilled water extract exhibited the most potent antibacterial activity, showing significant inhibition zones and low MIC values against all tested pathogens, with notable effectiveness against Shigella sp. (32 mm ZOI, 78 µg/mL MIC). The study also identified key bioactive pigments, viz., β, β-dimethylacrylshikonin, Deoxy-shikonin, and shikonin through Ultra Performance Liquid Chromatography, which contribute to the antibacterial properties. To conclude, A. euchroma exhibited significant in vitro antibacterial potency, validating its traditional use and emphasizing the need for further pharmacological and biotechnological evaluation.

本研究评估了来自跨喜马拉雅地区的极度濒危药用植物紫草（Ratanjot）的抑菌效果，用甲醇、乙醇和蒸馏水制备的紫草根提取物对人类病原体的抑菌效果，包括产气肠杆菌、变形杆菌、肺炎克雷伯菌、志贺氏菌、大肠杆菌ATCC 10418和伤寒沙门氏菌NCTC 786。采用琼脂孔扩散法和最低抑菌浓度法测定其抑菌活性。结果表明，蒸馏水提取物的抑菌活性最强，对所有病原菌均有明显的抑菌带和较低的MIC值，对志贺氏菌（32 mm ZOI, 78 µg/mL MIC）的抑菌效果显著。同时，通过超高效液相色谱法鉴定出了影响紫草抗菌性能的主要生物活性色素：β、β-二甲基丙烯型紫草素、脱氧紫草素和紫草素。综上所述，赤藻显示出显著的体外抗菌效力，证实了其传统用途，并强调需要进一步的药理学和生物技术评价。

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引用次数: 0

Biological and pharmacological activities, phytochemical profile, and ecological sustainability aspects of Cichorium intybus: An account of knowledge gaps and existing approaches 菊苣的生物和药理活性、植物化学特征和生态可持续性方面：知识差距和现有方法的说明

Pharmacological Research - Natural Products

Pub Date : 2025-12-09 DOI: 10.1016/j.prenap.2025.100450

Aisha Azad , Shoaib Hussain , Hina Akram , Hina Fida , Talib E. Butt

Chicory, known as Kashni, refers to Cichorium intybus L., a plant from the Asteraceae family, native to the Mediterranean region, with a long-standing history as a medicinal herb. It contains several key components that play a vital role in treating various health conditions. Many cultures have traditionally utilized this herb. Chicory also exhibits a wide range of pharmacological properties. The review studies in the literature to date do not appear to have captured the existing knowledge regarding this plant in terms of following in one place: phytochemical profile, biological and medicinal activities; such that the knowledge gaps along with the current approaches used to overcome the corresponding limitations associated with the knowledge gaps, need to be accounted for. A comprehensive literature review was conducted using reputable databases, including ScienceDirect, Google Scholar, Scopus, and PubMed. This review research included over one hundred articles, research theses, and books that focused on the ethnobotany, extraction and isolation of chemical constituents, bioactivities of C. intybus, and its role in nanoparticle synthesis. The study covered scientific publications from 1995 to 2024. The paper provides a comprehensive overview of the bioactive composition of C. intybus, highlighting its pharmacological activities linked to plant secondary metabolites based on recent findings. It also explores the plant's occurrence, morphology, geographic distribution, and its role in the green synthesis of nanoparticles. Additionally, the review identifies and narrates gaps in toxicological research, strategies to address these gaps, limitations, and future directions. In conclusion, C. intybus is a remarkable plant that warrants further study through innovative approaches.

菊苣，被称为Kashni，指菊苣属植物，一种菊科植物，原产于地中海地区，作为草药有着悠久的历史。它包含几个关键组成部分，在治疗各种健康状况方面发挥至关重要的作用。许多文化传统上都使用这种草药。菊苣还具有广泛的药理特性。迄今为止，文献中的综述研究似乎没有在以下一个方面涵盖有关该植物的现有知识：植物化学概况，生物和药用活性；因此，需要考虑到知识差距以及用于克服与知识差距相关的相应限制的当前方法。全面的文献综述使用了有信誉的数据库，包括ScienceDirect、谷歌Scholar、Scopus和PubMed。本综述收录了百余篇文献、研究论文和专著，重点介绍了紫苣苔的民族植物学、化学成分的提取与分离、生物活性及其在纳米颗粒合成中的作用。该研究涵盖了1995年至2024年的科学出版物。本文综述了青霉的生物活性成分，重点介绍了其与植物次生代谢物相关的药理活性。它还探讨了植物的发生、形态、地理分布及其在纳米颗粒绿色合成中的作用。此外，该综述确定并叙述了毒理学研究中的差距，解决这些差距的策略，限制和未来方向。综上所述，春菊是一种值得进一步研究的植物。

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引用次数: 0

Advancing psoriasis management through the application of secondary metabolites: A detailed review of phytoconstituents and their multifaceted mechanisms 通过应用次生代谢物推进牛皮癣管理：植物成分及其多方面机制的详细综述

Pharmacological Research - Natural Products

Pub Date : 2025-12-09 DOI: 10.1016/j.prenap.2025.100451

Farooque Nasir Shaikh , Sohail Shakeel Sheikh , Amol Tatode , Ujban Md Hussain , Tanvi Premchandani , Rahmuddin Khan , Preeti Sharma , Mohammad Qutub

Psoriasis is a chronic autoimmune skin disorder marked by keratinocyte hyperproliferation and T cell–mediated inflammation. Affecting 1–2 % of the global population, it is associated with comorbidities such as cardiovascular disease, metabolic syndrome, and depression. Conventional treatments including topical agents, phototherapy, and biologics offer symptomatic relief but are limited by adverse effects, high costs, and treatment resistance. To address these clinical challenges, plant-derived secondary metabolites (phytoconstituents) have emerged as safer, mechanism-based alternatives. Among these, curcumin, berberine, and Aloe vera demonstrate the greatest prospect for clinical translation, exhibiting potent anti-inflammatory and immunomodulatory effects through the inhibition of NF-κB, MAPK, and STAT3 pathways. These compounds not only regulate cytokine production and keratinocyte proliferation but also offer a solution to the toxicity and financial burden of long-term conventional therapy. This review consolidates current evidence on phytoconstituents in psoriasis management, emphasizing their role as effective, low-toxicity adjuncts or alternatives. Future research must focus on optimizing delivery systems to fully realize their translational potential in clinical settings.

银屑病是一种慢性自身免疫性皮肤病，以角质细胞增生和T细胞介导的炎症为特征。影响全球人口的1 - 2% ，它与心血管疾病、代谢综合征和抑郁症等合并症有关。包括局部药物、光疗和生物制剂在内的传统治疗方法可以缓解症状，但由于副作用、高成本和治疗耐药性而受到限制。为了应对这些临床挑战，植物衍生的次生代谢物（植物成分）已经成为更安全、基于机制的替代品。其中，姜黄素、小檗碱和芦荟通过抑制NF-κB、MAPK和STAT3通路，表现出强大的抗炎和免疫调节作用，具有最大的临床翻译前景。这些化合物不仅可以调节细胞因子的产生和角质细胞的增殖，而且还可以解决长期常规治疗的毒性和经济负担。这篇综述整合了目前关于植物成分在牛皮癣治疗中的证据，强调了它们作为有效的、低毒性的辅助剂或替代品的作用。未来的研究必须集中在优化输送系统，以充分发挥其在临床环境中的转化潜力。

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引用次数: 0

From biodiversity to clinical translation: A global review of lichen-derived natural products and their pharmacological potential 从生物多样性到临床转化：地衣衍生的天然产物及其药理潜力的全球综述

Pharmacological Research - Natural Products

Pub Date : 2025-12-09 DOI: 10.1016/j.prenap.2025.100456

Meixia Yang , Lisha Lyu , Xinyu Wang , Shengying Lin , Ka Wing Leung , Tina Tingxia Dong , Lisong Wang , Karl Wah Keung Tsim

Lichens, which are unique ecosystems formed by fungi and photosynthetic partners like algae or cyanobacteria, hold great potential for drug discovery. This review compiled four decades of research to create the first comprehensive global database of 14,230 lichen species, among which 116 were highlighted for proven medicinal properties. Our spatial analysis identified key regions for therapeutic potential, such as Europe, coastal North America, East Asia, and Oceania, with the Parmeliaceae family was found to contain the most bioactive species. We systematically described 82 lichen-derived metabolites with confirmed pharmacological effects. Depsidones show promise as agents against oxidative stress and cancer; depsides/polysaccharides demonstrate efficacy in modulating neuroinflammation and immune response; and terpenoids contribute to addressing antimicrobial resistance. Cytotoxic, anticancer, anti-tumor, anti-microbial, and antioxidant activities are associated with the largest number of medicinal species. This research bridges traditional knowledge of lichens with modern pharmacology, identifying 195 medicinal species that need further validation for clinical use. We also discussed challenges in translating this knowledge into practice, such as ensuring sustainable biomass, optimizing bioavailability, and ensuring clinical safety, and we suggested lichen-specific guidelines for these processes. As lichen metabolites offer compelling opportunities to tackle pressing global health issues, such as antimicrobial resistance, neurodegenerative disorders, and cancer, we advocate for lichen metabolites as promising solutions for future pharmaceutical development.

地衣是由真菌和藻类或蓝藻等光合作用伙伴形成的独特生态系统，具有巨大的药物发现潜力。这篇综述汇编了40年的研究，建立了第一个全面的全球地衣数据库，包括14230种地衣，其中116种被证明具有药用价值。我们的空间分析确定了治疗潜力的关键区域，如欧洲、北美沿海、东亚和大洋洲，其中发现Parmeliaceae家族含有最具生物活性的物种。我们系统地描述了82种地衣衍生的代谢物，证实了其药理作用。作为抗氧化应激和癌症的药物，Depsidones大有希望；深度/多糖在调节神经炎症和免疫反应方面表现出功效；萜类化合物有助于解决抗菌素耐药性问题。细胞毒性、抗癌、抗肿瘤、抗微生物和抗氧化活性与数量最多的药用物种有关。这项研究将地衣的传统知识与现代药理学联系起来，确定了195种需要进一步验证以供临床使用的药用物种。我们还讨论了将这些知识转化为实践的挑战，例如确保可持续生物量，优化生物利用度和确保临床安全性，并针对这些过程提出了地衣特定指南。由于地衣代谢物为解决紧迫的全球健康问题（如抗菌素耐药性、神经退行性疾病和癌症）提供了令人信服的机会，我们提倡将地衣代谢物作为未来药物开发的有希望的解决方案。

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引用次数: 0

Shrimp-derived extracts as antibacterial, antioxidant, and burn wound-healing agents: Comprehensive in vitro and in vivo evaluation from Yemeni coastal resources 虾源提取物作为抗菌、抗氧化和烧伤创面愈合剂：也门沿海资源的体外和体内综合评价

Pharmacological Research - Natural Products

Pub Date : 2025-12-09 DOI: 10.1016/j.prenap.2025.100454

Wafa M. Al-Madhagi , Mohammed A. Alkhawlani , Majed Alwan , Saleh Alomaisi , Maged Al-Najar

This study was aimed at evaluating shrimp extract formulations derived from Penaeus indicus for their antibacterial, antioxidant, and burn wound healing potential. Shrimp specimens were collected from coastal regions in Yemen and processed to separate shells and bodies. Chitin was isolated from shells via deproteinization and demineralization and subsequently converted to chitosan through deacetylation, while glucosamine sulphate was extracted from both shells and bodies using optimized hydrolysis protocols. The extracts were characterized by Fourier-transform infrared spectroscopy, melting point analysis, and UV–visible spectrophotometry. Antimicrobial activity was assessed using broth microdilution and disc diffusion assays against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Candida albicans. Antioxidant capacity was determined via the DPPH assay. In vivo burn wound healing efficacy was examined in murine models using both powder and ointment formulations of chitosan. Results revealed that chitosan exhibited significant antibacterial activity, with minimum inhibitory concentrations ranging from 0.0064 to 0.89 mg/mL, and the shell-derived glucosamine sulphate extract demonstrated potent free radical scavenging (IC₅₀ = 2.82 mg/μL). Moreover, 10 % chitosan formulations markedly accelerated wound healing, as evidenced by rapid re-epithelialization, reduced inflammation, and enhanced collagen deposition compared to lower concentrations and commercial treatments. Histopathological analysis confirmed superior tissue recovery in chitosan-treated groups, characterized by abundant collagen fibers, minimal inflammatory cells, and evidence of hair follicle regeneration. In conclusion, shrimp extract formulations, particularly those enriched with chitosan, offer a promising, cost-effective therapeutic strategy for burn wound management in resource-limited settings.

本研究旨在评价从印度对虾中提取的虾提取物的抗菌、抗氧化和烧伤愈合潜力。从也门沿海地区收集虾标本，并对其进行处理，以分离壳和体。通过脱蛋白和脱矿从壳中分离甲壳素，然后通过脱乙酰转化为壳聚糖，同时通过优化的水解方案从壳和体中提取硫酸氨基葡萄糖。采用傅里叶变换红外光谱、熔点分析和紫外可见分光光度法对提取物进行了表征。采用肉汤微稀释法和圆盘扩散法对大肠杆菌、铜绿假单胞菌、金黄色葡萄球菌和白色念珠菌进行抑菌活性评估。通过DPPH法测定抗氧化能力。研究了壳聚糖粉剂和软膏制剂在小鼠模型中烧伤创面的体内愈合效果。结果表明，壳聚糖具有显著的抗菌活性，最低抑菌浓度范围为0.0064至0.89 mg/mL，壳源性硫酸氨基葡萄糖提取物具有有效的自由基清除能力（IC₅₀= 2.82 mg/μL）。此外，与低浓度和商业治疗相比，10% %壳聚糖配方显著加速了伤口愈合，证明了快速的再上皮化，减少炎症和增强胶原沉积。组织病理学分析证实，壳聚糖处理组的组织恢复良好，其特点是胶原纤维丰富，炎症细胞最少，毛囊再生。总之，虾提取物制剂，特别是那些富含壳聚糖的制剂，在资源有限的情况下为烧伤创面管理提供了一种有前途的、具有成本效益的治疗策略。

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