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Zeitschrift für Immunitaetsforschung, Experimentelle und Klinische Immunologie
Pub Date : 1976-04-01 DOI: 10.1016/S0300-872X(76)80020-0
W. Brehmer
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引用次数: 0
Experiences with DNCB Sensitization in Normal Human Individuals of Various Age Groups 不同年龄组正常人群中DNCB致敏的经验
Zeitschrift für Immunitaetsforschung, Experimentelle und Klinische Immunologie
Pub Date : 1976-04-01 DOI: 10.1016/S0300-872X(76)80006-6
P.A. Bürkle , E. Tönnesmann, S. Ahnefeld, F. Nobbe, K. Federlin

Using DNCB contact sensitization, the primary cellular immune response of 40 normal individuals was investigated. The response to DNCB in the younger age group was higher and stronger than in the older age group, suggesting a decrease of T-cell function in elderly subjects. The simultaneous application of a high (1000 µg) and a low (100 µg) dose of DNCB for quantitation of the reactivity gave good results. However, in several cases — especially in the younger age group — the local reactions reached unexpected intensity followed by long lasting pigmentation. One investigator exhibited contact eczema on both hands after sensitization by merely touching the skin area of a previous DNCB reaction. Because of the potent immunogenicity of this substance and the possibility of cross reactions with numerous similar antigens widely used in the chemical and related industry, this test should only be applied in selected cases.

采用DNCB接触致敏法，观察40例正常人的原代细胞免疫反应。与老年组相比，年轻组对DNCB的反应更高、更强，这表明老年受试者的t细胞功能下降。同时应用高剂量(1000µg)和低剂量(100µg)的DNCB定量测定反应性，结果良好。然而，在一些情况下，特别是在年轻的年龄组中，局部反应达到了意想不到的强度，随后是持久的色素沉着。一名研究人员仅通过触摸先前DNCB反应的皮肤区域，在致敏后双手出现了接触性湿疹。由于该物质具有强大的免疫原性，并且可能与化学和相关工业中广泛使用的许多类似抗原发生交叉反应，因此该试验仅适用于选定的病例。
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引用次数: 1
Zeitschrift für Immunitaetsforschung, Experimentelle und Klinische Immunologie
Pub Date : 1976-03-01 DOI: 10.1016/S0300-872X(76)80061-3
G. May
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引用次数: 1
Zeitschrift für Immunitaetsforschung, Experimentelle und Klinische Immunologie
Pub Date : 1976-03-01 DOI: 10.1016/S0300-872X(76)80056-X
R. Lavfs
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引用次数: 0
Zeitschrift für Immunitaetsforschung, Experimentelle und Klinische Immunologie
Pub Date : 1976-03-01 DOI: 10.1016/S0300-872X(76)80062-5
H. Warnatz
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引用次数: 0
Zeitschrift für Immunitaetsforschung, Experimentelle und Klinische Immunologie
Pub Date : 1976-03-01 DOI: 10.1016/S0300-872X(76)80063-7
H. Warnatz
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引用次数: 0
Zeitschrift für Immunitaetsforschung, Experimentelle und Klinische Immunologie
Pub Date : 1976-03-01 DOI: 10.1016/S0300-872X(76)80059-5
H. Brandis
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引用次数: 0
Zeitschrift für Immunitaetsforschung, Experimentelle und Klinische Immunologie
Pub Date : 1976-03-01 DOI: 10.1016/S0300-872X(76)80058-3
H. Brandis
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引用次数: 0
Zeitschrift für Immunitaetsforschung, Experimentelle und Klinische Immunologie
Pub Date : 1976-03-01 DOI: 10.1016/S0300-872X(76)80064-9
H. Brandis
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引用次数: 0
Zeitschrift für Immunitaetsforschung, Experimentelle und Klinische Immunologie
Pub Date : 1976-03-01 DOI: 10.1016/S0300-872X(76)80060-1
Finger
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引用次数: 0
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