Objective: There are increasing studies examining retinal fiber layer (RNFL) and ganglion cell layer (GCL) thinning in patients with schizophrenia. However, the results are controversial, and clinical and cognitive reflections of these findings remain unclear. With this study, we aim to examine retinal abnormalities and establish correlations with cognitive and clinical parameters.
Methods: In this cross-sectional study, we examined 29 patients with schizophrenia and 13 age and gender-matched healthy controls. All participants underwent psychometric assessment, neuropsychological tests, and optical coherence tomography (OCT) measurements. The retinal fiber layer and ganglion cell layer thickness were used as retinal parameters.
Results: Five patients dropped out during the OCT measurement process, 24 patients with schizophrenia and nine healthy controls were included in the analysis. There was no statistically significant difference between groups in measuring retinal nerve fiber layer or ganglion cell layer thicknesses. The verbal fluency test score negatively correlated with left RNFL superior ( ρ – .422, p
目的:对精神分裂症患者视网膜纤维层(RNFL)和神经节细胞层(GCL)变薄的研究越来越多。然而，结果是有争议的，这些发现的临床和认知反映仍然不清楚。在这项研究中，我们的目的是检查视网膜异常，并建立与认知和临床参数的相关性。
方法:在这项横断面研究中，我们检查了29例精神分裂症患者和13例年龄和性别匹配的健康对照。所有参与者都进行了心理测量评估、神经心理测试和光学相干断层扫描(OCT)测量。以视网膜纤维层和神经节细胞层厚度作为视网膜参数。
结果:5例患者在OCT测量过程中退出，24例精神分裂症患者和9例健康对照纳入分析。各组间测量视网膜神经纤维层及神经节细胞层厚度差异无统计学意义。语言流畅性测试分数与左侧RNFL优势呈负相关(ρ - 0.422, p
{"title":"Neuropsychological and Clinical Correlations of Optical Coherence Tomography Findings in Patients with Schizophrenia","authors":"Ayşe SAKALLI KANİ, Cansun ŞAHİN ÇAM, Esra BİBEROĞLU ÇELİK, Uzay DURAL, Melike DURAN DÖNMEZ, Semra AKKAYA TURHAN, Ebru TOKER, Mesut YILDIZ","doi":"10.33808/clinexphealthsci.1331234","DOIUrl":"https://doi.org/10.33808/clinexphealthsci.1331234","url":null,"abstract":"Objective: There are increasing studies examining retinal fiber layer (RNFL) and ganglion cell layer (GCL) thinning in patients with schizophrenia. However, the results are controversial, and clinical and cognitive reflections of these findings remain unclear. With this study, we aim to examine retinal abnormalities and establish correlations with cognitive and clinical parameters.
 Methods: In this cross-sectional study, we examined 29 patients with schizophrenia and 13 age and gender-matched healthy controls. All participants underwent psychometric assessment, neuropsychological tests, and optical coherence tomography (OCT) measurements. The retinal fiber layer and ganglion cell layer thickness were used as retinal parameters.
 Results: Five patients dropped out during the OCT measurement process, 24 patients with schizophrenia and nine healthy controls were included in the analysis. There was no statistically significant difference between groups in measuring retinal nerve fiber layer or ganglion cell layer thicknesses. The verbal fluency test score negatively correlated with left RNFL superior ( ρ – .422, p","PeriodicalId":10192,"journal":{"name":"Clinical and Experimental Health Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135307678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-05DOI: 10.33808/clinexphealthsci.1261380
Nursel Alp Dal, K. Beydağ, Aysel Doğan
Objective: This research was conducted to identify the effect of the practice of Guided Imagery on the perceived stress level in high-risk pregnancies. Methods: The study was designed as a prospective, randomized, and single-blind study. The research was performed with the participation of a total of 128 women (64 in the experimental group, 64 in the control group) who had high-risk pregnancies between February-May, 2021. The data were evaluated with the Perceived Stress Scale. Results: The experimental group obtained a lower mean of post-test scores (26.36±5.96) from the Perceived Stress Scale than the control group (30.48±3.93), and this difference was statistically significant (p
{"title":"Effect of the Practice of Guided Imagery on the Perceived Stress Level in High-Risk Pregnancies","authors":"Nursel Alp Dal, K. Beydağ, Aysel Doğan","doi":"10.33808/clinexphealthsci.1261380","DOIUrl":"https://doi.org/10.33808/clinexphealthsci.1261380","url":null,"abstract":"Objective: This research was conducted to identify the effect of the practice of Guided Imagery on the perceived stress level in high-risk pregnancies. \u0000Methods: The study was designed as a prospective, randomized, and single-blind study. The research was performed with the participation of a total of 128 women (64 in the experimental group, 64 in the control group) who had high-risk pregnancies between February-May, 2021. The data were evaluated with the Perceived Stress Scale. \u0000Results: The experimental group obtained a lower mean of post-test scores (26.36±5.96) from the Perceived Stress Scale than the control group (30.48±3.93), and this difference was statistically significant (p","PeriodicalId":10192,"journal":{"name":"Clinical and Experimental Health Sciences","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2023-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48245735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-01DOI: 10.33808/clinexphealthsci.1112286
Ali Ceylan, Ertuğrul Demirdel
Objective: Our study was planned to examine the academic achievement, physical activity, smart phone use and sleep quality of university students. Methods: Young individuals between the ages of 18-25 studying at a vocational school were included in the study. While recording the demographic information of the participants, individuals were classified as "heavy users" and "light users", taking into account the duration of smartphone use during the day. In addition, the physical activity levels of the individuals were evaluated with the International Physical Activity Questionnaire-Short Form (IPAQ-SF), the smartphone usage level with the Smartphone Addiction Scale-Short Form (SAS-SF), and the sleep quality with the Pittsburg Sleep Quality Index (PSQI). Results: A total of 424 people, 326 of whom were women, with a mean age of 20.30±1.34 years, participated in the study. It was determined that 70.3% of the participants used smartphones for more than 4 hours a day. It was determined that there was a weak negative correlation between the academic success of the students and their physical activity levels, and that their academic success was not affected by smart phone use and sleep quality. However, it was determined that there was a weak positive correlation between the sleep quality of the students and their smartphone use. It was observed that the physical activity levels of male students were higher, while the academic success and sleep quality of normal education students were better. Conclusion: We think that active life, adequate and conscious smartphone use and quality sleep habits can affect academic success in university students.
{"title":"The Relationship Between Academic Performance and Physical Activity, Smart Phone Use and Sleep Quality in University Students","authors":"Ali Ceylan, Ertuğrul Demirdel","doi":"10.33808/clinexphealthsci.1112286","DOIUrl":"https://doi.org/10.33808/clinexphealthsci.1112286","url":null,"abstract":"Objective: Our study was planned to examine the academic achievement, physical activity, smart phone use and sleep quality of university students. \u0000Methods: Young individuals between the ages of 18-25 studying at a vocational school were included in the study. While recording the demographic information of the participants, individuals were classified as \"heavy users\" and \"light users\", taking into account the duration of smartphone use during the day. In addition, the physical activity levels of the individuals were evaluated with the International Physical Activity Questionnaire-Short Form (IPAQ-SF), the smartphone usage level with the Smartphone Addiction Scale-Short Form (SAS-SF), and the sleep quality with the Pittsburg Sleep Quality Index (PSQI). \u0000Results: A total of 424 people, 326 of whom were women, with a mean age of 20.30±1.34 years, participated in the study. It was determined that 70.3% of the participants used smartphones for more than 4 hours a day. It was determined that there was a weak negative correlation between the academic success of the students and their physical activity levels, and that their academic success was not affected by smart phone use and sleep quality. However, it was determined that there was a weak positive correlation between the sleep quality of the students and their smartphone use. It was observed that the physical activity levels of male students were higher, while the academic success and sleep quality of normal education students were better. \u0000Conclusion: We think that active life, adequate and conscious smartphone use and quality sleep habits can affect academic success in university students.","PeriodicalId":10192,"journal":{"name":"Clinical and Experimental Health Sciences","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41648866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: This study was conducted to investigate the relationship between trunk control and lower extremity sense, balance and gait in stroke individuals. Methods: Thirty subacute and chronic stroke patients were included in the study (mean age 52. 2 14.4 years). Trunk Impairment Scale (TIS) and Turkish version of Postural Assessment Scale for Stroke Patients (PASS-T) was used for evaluating the body control, and Tinetti Balance Test (TBT) was used for evaluating balance. Tinetti Gait Test (TGT) and Ten Meter Walking Test (TMWT) were applied for evaluating walking. The light touch sense and proprioception, Fugl-Meyer Assessment of Sensorimotor Function (FMASF) for lower extremity were used. Furthermore, neglect, plantar pressure sense and stereognosis for lower extremity were evaluated. Results: There was a significant positively strong correlation between TIS and TBT, TGT and FMSMFT, and negatively strong correlation between TIS and TMWT (p
{"title":"The Relationship of Trunk Control with Lower Extremity Sense, Balance, and Walking in Individuals with Stroke","authors":"Zehra Ekmekçi̇oğlu, Zekiye İpek Katırcı Kırmacı, Nevin Ergun","doi":"10.33808/clinexphealthsci.1094360","DOIUrl":"https://doi.org/10.33808/clinexphealthsci.1094360","url":null,"abstract":"Objective: This study was conducted to investigate the relationship between trunk control and lower extremity sense, balance and gait in stroke individuals. \u0000Methods: Thirty subacute and chronic stroke patients were included in the study (mean age 52. 2 14.4 years). Trunk Impairment Scale (TIS) and Turkish version of Postural Assessment Scale for Stroke Patients (PASS-T) was used for evaluating the body control, and Tinetti Balance Test (TBT) was used for evaluating balance. Tinetti Gait Test (TGT) and Ten Meter Walking Test (TMWT) were applied for evaluating walking. The light touch sense and proprioception, Fugl-Meyer Assessment of Sensorimotor Function (FMASF) for lower extremity were used. Furthermore, neglect, plantar pressure sense and stereognosis for lower extremity were evaluated. \u0000Results: There was a significant positively strong correlation between TIS and TBT, TGT and FMSMFT, and negatively strong correlation between TIS and TMWT (p","PeriodicalId":10192,"journal":{"name":"Clinical and Experimental Health Sciences","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46062332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-01DOI: 10.33808/clinexphealthsci.1123209
Taşkın Özkan, Arzu Güçlü Gündüz, F. Soke, Çağla Özkul, Y. Apaydin, Kader Eldemir, C. Irkec
Objective: The trunk is known to be the most important key point where sensory inputs are received and motor responses occur, necessary for the maintenance of balance and postural control. The aims of the present study were to investigate the relationship between balance with core stability and position sense of trunk in patients with Multiple Sclerosis (PwMS) and to compare core stability, position sense of trunk and balance in PwMS and healthy controls. Methods: The study was completed with 45 PwMS and 29 healthy controls with matching age and gender. Balance was assessed with Postural Stability Test (PST) and Modified Sensory Organization Test (MSOT) by using Biodex Balance System®. Core stability was evaluated with core endurance tests according to McGill procedure. Position sense of trunk was evaluated with the lumbosacral (LS) reposition tests by using Dualer IQTM digital inclinometer. Results: PST, MSOT and LS repositioning tests scores were higher (p
{"title":"Do The Core Stability and Position Sense of Trunk Affect Balance in Patients with Multiple Sclerosis?","authors":"Taşkın Özkan, Arzu Güçlü Gündüz, F. Soke, Çağla Özkul, Y. Apaydin, Kader Eldemir, C. Irkec","doi":"10.33808/clinexphealthsci.1123209","DOIUrl":"https://doi.org/10.33808/clinexphealthsci.1123209","url":null,"abstract":"Objective: The trunk is known to be the most important key point where sensory inputs are received and motor responses occur, necessary for the maintenance of balance and postural control. The aims of the present study were to investigate the relationship between balance with core stability and position sense of trunk in patients with Multiple Sclerosis (PwMS) and to compare core stability, position sense of trunk and balance in PwMS and healthy controls. \u0000Methods: The study was completed with 45 PwMS and 29 healthy controls with matching age and gender. Balance was assessed with Postural Stability Test (PST) and Modified Sensory Organization Test (MSOT) by using Biodex Balance System®. Core stability was evaluated with core endurance tests according to McGill procedure. Position sense of trunk was evaluated with the lumbosacral (LS) reposition tests by using Dualer IQTM digital inclinometer. \u0000Results: PST, MSOT and LS repositioning tests scores were higher (p","PeriodicalId":10192,"journal":{"name":"Clinical and Experimental Health Sciences","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45555708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-01DOI: 10.33808/clinexphealthsci.1116402
Amr ABDEL-AZİEM, Ibrahim Dewi̇r, Mosab Aloti̇bi̇, Hamzh Morshed, Ziyad Alkhammash, Muqren Alshahrani̇
Objective: This study aimed to determine the prevalence of smartphones addiction, and to investigate the relationship between smartphones addiction and functional neck disability among the students of Taif University during a Covid-19 pandemic. Methods: A 1060 students from Taif University participated in this study. The smartphones addiction was evaluated by using the short version of the smartphone’s addiction scale (SAS-SV) and functional neck disability was measured by the neck disability index (NDI). Results: About 83 % of the students reported smartphones addiction, 50% were suffering from mild neck disability, and 84% used their smartphones for more than 4 hours/day. Female students represented one and half times more than male to develop a smartphones addiction (p< 0.05). There was a significant association between smartphones addition and neck disability (p< 0.05). Moreover, female students had a functional neck disability significantly greater than male students (p= 0.001). Students with smartphones addiction represented three times more than students without addiction to develop functional neck disability (p= 0.001), and female students represented two times more than male students to develop functional neck disability (p= 0.001). Conclusion: During a COVID-19 pandemic, more than four-fifth of the students showed smartphones addiction. The female students are more predictive to smartphones addiction than male. The smartphones addiction and female students were found to be the predictors for functional neck disability.
{"title":"The Relationship between Smartphone Addiction and Functional Neck Disability among University Students during COVID-19 Pandemic","authors":"Amr ABDEL-AZİEM, Ibrahim Dewi̇r, Mosab Aloti̇bi̇, Hamzh Morshed, Ziyad Alkhammash, Muqren Alshahrani̇","doi":"10.33808/clinexphealthsci.1116402","DOIUrl":"https://doi.org/10.33808/clinexphealthsci.1116402","url":null,"abstract":"Objective: This study aimed to determine the prevalence of smartphones addiction, and to investigate the relationship between smartphones addiction and functional neck disability among the students of Taif University during a Covid-19 pandemic. \u0000Methods: A 1060 students from Taif University participated in this study. The smartphones addiction was evaluated by using the short version of the smartphone’s addiction scale (SAS-SV) and functional neck disability was measured by the neck disability index (NDI). \u0000Results: About 83 % of the students reported smartphones addiction, 50% were suffering from mild neck disability, and 84% used their smartphones for more than 4 hours/day. Female students represented one and half times more than male to develop a smartphones addiction (p< 0.05). There was a significant association between smartphones addition and neck disability (p< 0.05). Moreover, female students had a functional neck disability significantly greater than male students (p= 0.001). Students with smartphones addiction represented three times more than students without addiction to develop functional neck disability (p= 0.001), and female students represented two times more than male students to develop functional neck disability (p= 0.001). \u0000Conclusion: During a COVID-19 pandemic, more than four-fifth of the students showed smartphones addiction. The female students are more predictive to smartphones addiction than male. The smartphones addiction and female students were found to be the predictors for functional neck disability.","PeriodicalId":10192,"journal":{"name":"Clinical and Experimental Health Sciences","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47794518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-25DOI: 10.33808/clinexphealthsci.1221688
Gülan Albaş Kurt, Alperen Saritaş, E. Atay, A. Ertekin, Y. E. Kundakcı, Tolga Erteki̇n
Objective: Neural tube defects are one of the congenital malformations of the central nervous system. Although the factors that cause the development of neural tube defects and their mechanisms of action are still not clearly explained, genetic predisposition, drug use and some environmental factors are thought to play a role. In this study, it was aimed to investigate the effects of zuclopenthixol acetate (ZA) on neural tube development in a chick embryo model. Methods: Fourty specific pathogen-free (SPF) eggs were used in the study. The eggs were incubated for 28 hours and divided into four groups of 10 eggs each. At the end of the 28th hours, saline was injected to the control group, while ZA was administered subblastodermically to the experimental groups in 3 different doses (0.7, 1.4, 2.1 mg/kg). At the end of the 48th hours, all the eggs were opened and the embryos were dissected from the embryonic membranes and evaluated morphologically and histopathologically. Results: When the study groups were evaluated according to the neural tube positions (open or closed), it was found that the neural tube patency increased depending on the ZA dose, which was statistically significant (p < 0.05). In addition, morphological developments of embryos were evaluated. Compared to the control group, a statistically significant decrease was observed in the mean somite numbers in all ZA-treated groups, while a significant decrease was found in the mean cranio-caudal length only in the high-dose group. Conclusion: In this study, it was observed that neural tube and morphological development were adversely affected in the groups treated with ZA in the chick embryo model. It was shown that neural tube closure defects in embryos increased in direct proportion with ZA doses. However, we believe that it will not be possible to fully adapt the results of this study, which was carried out in the chick embryo model, to humans and that more comprehensive research should be conducted.
{"title":"Effect of Zuclopenthixol Acetate on Neural Tube Development in Early Chick Embryos Effect of Zuclopenthixol Acetate","authors":"Gülan Albaş Kurt, Alperen Saritaş, E. Atay, A. Ertekin, Y. E. Kundakcı, Tolga Erteki̇n","doi":"10.33808/clinexphealthsci.1221688","DOIUrl":"https://doi.org/10.33808/clinexphealthsci.1221688","url":null,"abstract":"Objective: Neural tube defects are one of the congenital malformations of the central nervous system. Although the factors that cause the development of neural tube defects and their mechanisms of action are still not clearly explained, genetic predisposition, drug use and some environmental factors are thought to play a role. In this study, it was aimed to investigate the effects of zuclopenthixol acetate (ZA) on neural tube development in a chick embryo model. Methods: Fourty specific pathogen-free (SPF) eggs were used in the study. The eggs were incubated for 28 hours and divided into four groups of 10 eggs each. At the end of the 28th hours, saline was injected to the control group, while ZA was administered subblastodermically to the experimental groups in 3 different doses (0.7, 1.4, 2.1 mg/kg). At the end of the 48th hours, all the eggs were opened and the embryos were dissected from the embryonic membranes and evaluated morphologically and histopathologically. Results: When the study groups were evaluated according to the neural tube positions (open or closed), it was found that the neural tube patency increased depending on the ZA dose, which was statistically significant (p < 0.05). In addition, morphological developments of embryos were evaluated. Compared to the control group, a statistically significant decrease was observed in the mean somite numbers in all ZA-treated groups, while a significant decrease was found in the mean cranio-caudal length only in the high-dose group. Conclusion: In this study, it was observed that neural tube and morphological development were adversely affected in the groups treated with ZA in the chick embryo model. It was shown that neural tube closure defects in embryos increased in direct proportion with ZA doses. However, we believe that it will not be possible to fully adapt the results of this study, which was carried out in the chick embryo model, to humans and that more comprehensive research should be conducted.","PeriodicalId":10192,"journal":{"name":"Clinical and Experimental Health Sciences","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2023-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139355577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-05DOI: 10.33808/clinexphealthsci.1199615
Elif Ayazoglu Demir, A. Menteşe, Hatice Küçük, Nihal Türkmen, S. Demir, Y. Aliyazicioglu
Objective: Although 5-fluorouracil (5-FU) is one of the most commonly used chemotherapeutics worldwide, it has been shown that 5-FU administration can cause reproductive toxicity in recent years. N-acetylcysteine (NAC) is the precursor of glutathione, the most important endogenous antioxidant molecule and is known for its effective antioxidant and anti-inflammatory properties. Although NAC is one of the most studied antioxidant molecules, its curative effect against ovarian damage caused by 5-FU has not been demonstrated to date. It was therefore aimed to investigate whether NAC is therapeutic against 5-FU-induced ovotoxicity in this study for the first time. Methods: Rats were first exposed to a single dose of 5-FU (100 mg/kg) and then treated with NAC (10 and 20 mg/kg) for three days. The oxidative stress, inflammation and apoptosis markers in ovarian tissues were also determined using spectrophotometric methods. Ovarian tissues were also evaluated histologically. Results: It was revealed that the levels of oxidative stress, inflammation and apoptosis biomarkers in ovarian tissue increased by 5-FU administration (p
{"title":"N-Acetylcysteine Ameliorates 5-Fluorouracil‐Induced Ovarian Injury in Rats","authors":"Elif Ayazoglu Demir, A. Menteşe, Hatice Küçük, Nihal Türkmen, S. Demir, Y. Aliyazicioglu","doi":"10.33808/clinexphealthsci.1199615","DOIUrl":"https://doi.org/10.33808/clinexphealthsci.1199615","url":null,"abstract":"Objective: Although 5-fluorouracil (5-FU) is one of the most commonly used chemotherapeutics worldwide, it has been shown that 5-FU administration can cause reproductive toxicity in recent years. N-acetylcysteine (NAC) is the precursor of glutathione, the most important endogenous antioxidant molecule and is known for its effective antioxidant and anti-inflammatory properties. Although NAC is one of the most studied antioxidant molecules, its curative effect against ovarian damage caused by 5-FU has not been demonstrated to date. It was therefore aimed to investigate whether NAC is therapeutic against 5-FU-induced ovotoxicity in this study for the first time. Methods: Rats were first exposed to a single dose of 5-FU (100 mg/kg) and then treated with NAC (10 and 20 mg/kg) for three days. The oxidative stress, inflammation and apoptosis markers in ovarian tissues were also determined using spectrophotometric methods. Ovarian tissues were also evaluated histologically. Results: It was revealed that the levels of oxidative stress, inflammation and apoptosis biomarkers in ovarian tissue increased by 5-FU administration (p","PeriodicalId":10192,"journal":{"name":"Clinical and Experimental Health Sciences","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2023-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139362733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-05DOI: 10.33808/clinexphealthsci.1162013
Elif SARICA DAROL, Ayşe Karson, S. Köktürk, Pervin İşeri̇
Objective: Parkinson's disease is a progressive neurodegenerative disease having a spectrum of non-motor to motor symptoms. Unrelated to motor symptoms of sensory, autonomic, and neuropsychiatric symptoms often appear early in the course of the disease. It is a remarkable observation that patients in the premotor phase can easily quit smoking without help. This study was intended to investigate the interrelation between nicotine and the partial loss of dopaminergic innervation in the ventrolateral striatum induced by 6-OHDA. Methods: We used an experimental premotor parkinsonism model. The oral nicotine preference of rats was investigated with the two-bottle free choice method. The behaviors related to locomotor activity and emotional state were evaluated with a locomotor activity test, elevated plus maze, and forced swimming test. Histopathological evaluation was performed in the striatum by staining techniques using hematoxylin+eosin (H&E) and immunohistochemistry markers (caspase-3, and MAP-2). Results: Bilateral 6-OHDA lesions did not lead to a significant alteration in the total locomotor activity or nicotine preference. Nicotine increased horizontal but decreased vertical movements in addition to increasing anxiolytic but also depressive effects in the OHDA lesion group. The number of apoptotic cells was significantly lower in the lesion group receiving nicotine compared to those not receiving nicotine. Conclusion: Our experimental study points to the role of oral nicotine in male rats with bilateral striatal 6-OHDA lesions in the ventrolateral striatum. Further studies are needed to understand the relationship between loss of dopaminergic innervation in the striatum and nicotine consumption.
{"title":"Cellular, Behavioral, and Locomotor Effects of Oral Nicotine in Male Rats with Bilateral Lesions in the Ventrolateral Striatum Induced with 6-OHDA","authors":"Elif SARICA DAROL, Ayşe Karson, S. Köktürk, Pervin İşeri̇","doi":"10.33808/clinexphealthsci.1162013","DOIUrl":"https://doi.org/10.33808/clinexphealthsci.1162013","url":null,"abstract":"Objective: Parkinson's disease is a progressive neurodegenerative disease having a spectrum of non-motor to motor symptoms. Unrelated to motor symptoms of sensory, autonomic, and neuropsychiatric symptoms often appear early in the course of the disease. It is a remarkable observation that patients in the premotor phase can easily quit smoking without help. This study was intended to investigate the interrelation between nicotine and the partial loss of dopaminergic innervation in the ventrolateral striatum induced by 6-OHDA. \u0000Methods: We used an experimental premotor parkinsonism model. The oral nicotine preference of rats was investigated with the two-bottle free choice method. The behaviors related to locomotor activity and emotional state were evaluated with a locomotor activity test, elevated plus maze, and forced swimming test. Histopathological evaluation was performed in the striatum by staining techniques using hematoxylin+eosin (H&E) and immunohistochemistry markers (caspase-3, and MAP-2). \u0000Results: Bilateral 6-OHDA lesions did not lead to a significant alteration in the total locomotor activity or nicotine preference. Nicotine increased horizontal but decreased vertical movements in addition to increasing anxiolytic but also depressive effects in the OHDA lesion group. The number of apoptotic cells was significantly lower in the lesion group receiving nicotine compared to those not receiving nicotine. \u0000Conclusion: Our experimental study points to the role of oral nicotine in male rats with bilateral striatal 6-OHDA lesions in the ventrolateral striatum. Further studies are needed to understand the relationship between loss of dopaminergic innervation in the striatum and nicotine consumption.","PeriodicalId":10192,"journal":{"name":"Clinical and Experimental Health Sciences","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2023-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45068318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-19DOI: 10.33808/clinexphealthsci.1192493
Eda Aktaş, Çağrı Çövener Özçelik
Objective: Obesity is a metabolic disorder that occurs due to excessive body fat accumulation and can lead to physical and emotional problems. Preventing and treating obesity in childhood and adolescence is crucial. The aim of this study was to evaluate the effectiveness of obesity awareness education provided to fourth-grade elementary school students. Methods: An experimental study with pretest-posttest control group design was conducted. The study sample consisted of a total of 663 students, 344 students in the experimental group and 319 students in the control group, who attended the fourth grade of two elementary schools in Istanbul and met the inclusion criteria. Results: The sample included 326 girls (49.2%) and 337 boys (50.8%). The mean (SD) BMI was 18.45 (3.49) in the experimental group and 18.04 (3.00) in the control group. 73% (n = 251) of the students in the experimental group and 77.7% (n = 248) of the students in the control group stated that obesity only made walking/running difficult. There was no difference in obesity awareness scores between the experimental and control groups before the education (p=0.92). However, at 1 week and 1 month after the education, the experimental group had significantly higher scores compared to the control group (p
{"title":"Obesity Awareness Among Elementary School Students: A Controlled Before - After Study","authors":"Eda Aktaş, Çağrı Çövener Özçelik","doi":"10.33808/clinexphealthsci.1192493","DOIUrl":"https://doi.org/10.33808/clinexphealthsci.1192493","url":null,"abstract":"Objective: Obesity is a metabolic disorder that occurs due to excessive body fat accumulation and can lead to physical and emotional problems. Preventing and treating obesity in childhood and adolescence is crucial. The aim of this study was to evaluate the effectiveness of obesity awareness education provided to fourth-grade elementary school students. \u0000Methods: An experimental study with pretest-posttest control group design was conducted. The study sample consisted of a total of 663 students, 344 students in the experimental group and 319 students in the control group, who attended the fourth grade of two elementary schools in Istanbul and met the inclusion criteria. \u0000Results: The sample included 326 girls (49.2%) and 337 boys (50.8%). The mean (SD) BMI was 18.45 (3.49) in the experimental group and 18.04 (3.00) in the control group. 73% (n = 251) of the students in the experimental group and 77.7% (n = 248) of the students in the control group stated that obesity only made walking/running difficult. There was no difference in obesity awareness scores between the experimental and control groups before the education (p=0.92). However, at 1 week and 1 month after the education, the experimental group had significantly higher scores compared to the control group (p","PeriodicalId":10192,"journal":{"name":"Clinical and Experimental Health Sciences","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2023-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41423871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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