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The Effects of Petroleum Jelly Perineum Massage on Episiotomy and Perineum Healing in the 1st Stage of Labour: A Randomised Controlled Trial 凡士林会阴按摩对第一产程会阴切开和会阴愈合的影响:随机对照试验
IF 0.2 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2023-05-25 DOI: 10.33808/clinexphealthsci.1029390
Yağmur İRMAK ÇELİK, Meltem Demirgöz Bal
Aim: The aim of this study was to investigate the effect of perineal massage with vaseline on the episiotomy and perineal healing in nulliparous women. Method: The double-blind randomized controlled trial was conducted on 90 nulliparous women. In the interventions group, perineal massage was performed with Vaseline and without Vaseline from the active phase of labor. Control group no interventions were performed. Results: Perineal massage with vaseline in the intervention group significant decreased the rate of episiotomies (40%) compared to other group (p< 0.01). In the control group, the mean labor time was 10 hours 5 min, while in the perineal massage group with vaseline, this duration was determined to be 9 hours. (p
目的:本研究旨在探讨凡士林会阴按摩对未产妇会阴切开和会阴愈合的影响。方法:对90例未产妇进行双盲随机对照试验。干预组在分娩活跃期使用凡士林和不使用凡士林进行会阴按摩。对照组未进行干预。结果:与其他组相比,干预组用凡士林按摩会阴显著降低了会阴分娩率(40%)(p<0.01)。对照组的平均分娩时间为10小时5分钟,而用凡士林按摩的会阴组的平均产程时间为9小时。(p
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引用次数: 0
Comparison of the Rapid Antigen Test to RT-qPCR in Diagnosis of SARS-CoV-2: A University Experience in Northern Cyprus 北塞浦路斯大学快速抗原检测与RT-qPCR诊断SARS-CoV-2的比较研究
IF 0.2 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2023-05-06 DOI: 10.33808/clinexphealthsci.1082079
E. Güler, Ferdiye Taner, Erdal Şanlidağ, P. Tulay, M. C. Ergoren, B. Baddal, C. Özverel, G. Tuncel, Kaya Süer, T. Şanlıdağ
Objective: As an alternative to RT-qPCR assays used in the diagnosis SARS-CoV-2, antigen-detecting rapid diagnostic tests (Ag-RDTs) are available for the qualitative detection of SARS-CoV-2 in nasopharyngeal swab samples. The aim of this study was to assess the accuracy and reliability of Ag-RDTs as a diagnostic method of detecting SARS-CoV-2 positive cases within a given population. Methods: In first phase of this investigation, 357 nasopharyngeal swab samples were screened for SARS-CoV-2 using Ag-RDTs. For the purposes of this study RT-qPCR was then applied to the same 357 nasopharyngeal swab samples in order to compare the reliability of the two detection methods. In the second phase of this investigation, Ag-RDTs were applied to an additional 75 nasopharyngeal swab samples that were already known to be RT-qPCR positive. Results: In the first phase of this investigation, of the 357 samples screened using Ag-RDTs 14 samples were positive for SARS-CoV-2, in contrast, when RT-qPCR analysis was applied to the same 357 samples no SARS-CoV-2 samples were detected. Therefore, the false antigen positivity was determined to be at 3.9%. In the second phase of this investigation 75 RT-qPCR positive samples were re-evaluated with a rapid antigen test. Twenty-four of the 75 RT-qPCR positive sample were undetected. Conclusion: Solely relying on rapid antigen tests to detect SARS-CoV-2 infections in the community could consequently result in infectious individuals remaining in the population. The impact of false negative rapid test results can be reduced by implementing confirmatory RT-qPCR analysis particularly in symptomatic patients.
目的:抗原检测快速诊断试验(ag - rdt)可作为诊断SARS-CoV-2的RT-qPCR方法的替代方法,用于鼻咽拭子标本中SARS-CoV-2的定性检测。本研究的目的是评估ag - rdt作为在特定人群中检测SARS-CoV-2阳性病例的诊断方法的准确性和可靠性。方法:在本研究的第一阶段,使用ag - rdt对357份鼻咽拭子样本进行SARS-CoV-2筛查。为了本研究的目的,RT-qPCR随后应用于相同的357鼻咽拭子样本,以比较两种检测方法的可靠性。在本研究的第二阶段,将ag - rrt应用于另外75个已知为RT-qPCR阳性的鼻咽拭子样本。结果:在本研究的第一阶段,使用ag - rdt筛选的357份样本中,有14份样本呈SARS-CoV-2阳性,相反,当对相同的357份样本应用RT-qPCR分析时,未检测到SARS-CoV-2样本。因此,假抗原阳性确定为3.9%。在本研究的第二阶段,75个RT-qPCR阳性样本用快速抗原检测重新评估。75份RT-qPCR阳性样本中有24份未检出。结论:单纯依靠快速抗原检测检测社区中SARS-CoV-2感染可能导致感染个体残留在人群中。通过实施验证性RT-qPCR分析,特别是在有症状的患者中,可以减少假阴性快速检测结果的影响。
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引用次数: 0
The Effect of Mental Health on Health-Related Quality of Life in Adolescents 心理健康对青少年健康生活质量的影响
IF 0.2 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2023-05-02 DOI: 10.33808/clinexphealthsci.947603
Tuba Ak, Nesrin İlhan
Objective: The aim of this study was to determine the effect of mental health on health-related quality of life in adolescents. Methods: This cross-sectional study was conducted among 1188 students studying in a public high school in Istanbul, Turkey. Data were collected using the General Health Questionnaire (GHQ-12) and the Turkish Generic Health-Related Quality of Life Questionnaire for adolescents (Kiddo-KINDL). Descriptive statistics, correlation analysis and multiple regression analysis were used in the analysis. Results: The mean age of the adolescents was 16.61±1.17; 56.6% were female. This study shows that mental health was a negatively significantly related to all subscales of health-related quality of life (physical wellbeing, emotional wellbeing, self-esteem, family, friends, school) of adolescents (p
目的:本研究旨在确定心理健康对青少年健康相关生活质量的影响。方法:这项横断面研究在土耳其伊斯坦布尔一所公立高中的1188名学生中进行。使用一般健康问卷(GHQ-12)和土耳其青少年一般健康相关生活质量问卷(Kiddo KINDL)收集数据。分析采用描述性统计、相关分析和多元回归分析。结果:青少年平均年龄为16.61±1.17岁;56.6%为女性。这项研究表明,心理健康与青少年健康相关生活质量的所有分量表(身体健康、情绪健康、自尊、家人、朋友、学校)呈负相关(p
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引用次数: 0
Effect of Digitalization on Nursing Practices using the Lean Approach 数字化对精益护理实践的影响
IF 0.2 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2023-04-29 DOI: 10.33808/clinexphealthsci.904203
L. N. Uzun, Birgül Cerit
Objective: This study aimed to examine the effect of digitalization on nursing practices using the lean approach. Method: This is a descriptive observational study. The data were collected using an activity chart to record nurses’ direct and indirect care practices and personal work and the Value Stream Map to compare and analyze work processes and determine both waste and value areas in the clinics. The study included a total of 15 nurses from two different internal medicine units of a hospital, including one digital clinic that uses digital applications for nurse work processes, and one partial digital clinic that has limited digital applications. The data were analyzed using current state value stream mapping, lean seven waste areas, and future state value stream mapping. Results: In the digital clinic, 748.5 minutes were allocated for direct care, 129.1 minutes for indirect care, and 562.1 minutes for personal work. Total value-added time and non-value-added time was calculated as 1137.1 and 302.9 minutes, respectively. In the partial digital clinic, 623.9 minutes were allocated for direct care, 404.4 minutes for indirect care, and 411.1 minutes for personal work. Total value-added time and non-value-added time was calculated as 1006 and 433.4 minutes, respectively. According to the future state value stream map prepared in line with the improvement suggestions to eliminate unnecessary production, process, movement, transportation, waiting, and error waste in the current state of both clinics, it is predicted that 1354.3 minutes of value-added time will be obtained and non-value-added time will decrease to 85.7 minutes, by spending 910.9 minutes less on direct care, 190.2 minutes less on indirect care, and 259.2 minutes less on personal work. Conclusion: The lean approach creates a repeated opportunity to review and improve processes. Analyzing nursing processes using the lean approach before and after digitalization and reviewing sources of both waste and value will contribute to implementing higher quality nursing care practices more effectively and safely and to using time and staff more efficiently.
目的:探讨数字化对护理实践精益化的影响。方法:本研究为描述性观察性研究。数据收集使用活动图记录护士的直接和间接护理实践和个人工作,价值流图用于比较和分析工作流程,并确定诊所的浪费和价值领域。该研究共包括来自一家医院两个不同内科部门的15名护士,其中包括一个使用数字应用程序进行护士工作流程的数字诊所,以及一个使用有限数字应用程序的部分数字诊所。使用当前状态价值流映射、精益七个浪费区域和未来状态价值流映射来分析数据。结果:数字诊所直接护理时间为748.5分钟,间接护理时间为129.1分钟,个人工作时间为562.1分钟。计算总增值时间为1137.1分钟,非增值时间为302.9分钟。部分数字化诊所直接护理时间623.9分钟,间接护理时间404.4分钟,个人工作时间411.1分钟。计算总增值时间为1006分钟,非增值时间为433.4分钟。根据针对消除两家诊所当前状态下不必要的生产、流程、移动、运输、等待和错误浪费的改进建议所编制的未来状态价值流图,预计通过减少直接护理910.9分钟,减少间接护理190.2分钟,减少个人工作259.2分钟,将获得1354.3分钟的增值时间,非增值时间减少到85.7分钟。结论:精益方法为评审和改进过程创造了一个重复的机会。在数字化前后使用精益方法分析护理流程,审查浪费和价值的来源,将有助于更有效和安全地实施更高质量的护理实践,并更有效地利用时间和人员。
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引用次数: 0
The Turkish Validity and Reliability of The Adolescent Dysmenorrhea Self-Care Scale 青少年痛经自我护理量表的土耳其语效度和信度
IF 0.2 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2023-04-17 DOI: 10.33808/clinexphealthsci.983007
Enise Sürücü, Ayşegül Ergün
Objective: Dysmenorrhea is a common health problem that negatively affects daily life and academic skills when not managed well. This study was conducted to examine the Turkish validity and reliability of the Adolescent Dysmenorrhea Self-Care Scale. Methods: This methodological study was conducted in 7 high schools in Bursa, Turkey. The research was carried out with 1041 high school students who met the participation criteria. The Adolescent Dysmenorrhea Self-Care Scale was adapted to Turkish by using translation-back translation method. The validity of the scale was evaluated with the content validity index, confirmatory factor analysis, similarity and discriminant validity coefficients and reliability, item-total correlation, internal consistency coefficient and test-retest analysis. Results: According to the evaluations of the 10 experts whose opinions were taken for the Content Validity, it is determined that each item scored above 3 (3.52-4.00), and the mean score was 3.92 ± 0.14 and the content validity index was .98. Cronbach’s alpha reliability coefficient was found α = .96. Confirmatory factor analysis fit indexes and similarity and discriminant validity coefficients showed that the scale has sufficient compatibility with the theoretical six-factor structure. Item total correlations of subdimensions were r = .20-.68 and Cronbach's alpha coefficients were .77-.65. Test-retest correlations of the Adolescent Dysmenorrhea Self-Care Scale and its subdimensions were found r = .87-.99. Conclusion: Turkish Adolescent Dysmenorrhea Self-Care Scale is a valid and reliable data collection tool consisting of 40 items and six subdimensions.
目的:痛经是一种常见的健康问题,如果处理不好,会对日常生活和学习技能产生负面影响。本研究旨在检验青少年痛经自我护理量表的土耳其语效度和信度。方法:本方法学研究在土耳其布尔萨市的7所高中进行。该研究对1041名符合参与标准的高中生进行了调查。采用反译法将青少年痛经自我护理量表改编为土耳其语。采用内容效度指标、验证性因子分析、相似效度系数和判别效度系数及信度、项目-总相关、内部一致性系数和重测分析对量表进行效度评价。结果:根据对内容效度发表意见的10位专家的评价,确定各项目得分均在3分以上(3.52 ~ 4.00),平均得分为3.92±0.14,内容效度指数为0.98。Cronbach’s α信度系数为α = 0.96。验证性因子分析拟合指标、相似效度系数和判别效度系数表明,量表与理论六因子结构具有足够的相容性。各子维度项目总相关r = 0.20 -。Cronbach’s alpha系数为0.77 ~ 0.65。青少年痛经自我护理量表及其子维度的重测相关性r = 0.87 ~ 0.99。结论:土耳其青少年痛经自我护理量表由6个子维度、40个条目组成,是一个有效、可靠的数据收集工具。
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引用次数: 0
The Effect of Post-Operative Sexual Counseling Carried out with PLISSIT Model on Sexual Function and Sexual Satisfaction in Gynecologic Cancers PLISSIT模型下的术后性咨询对妇科癌症患者性功能和性满意度的影响
IF 0.2 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2023-04-17 DOI: 10.33808/clinexphealthsci.1169795
Çiğdem Bi̇lge, Ergul Aslan
Objective: This study aims to determine the effect of sexual counseling on the sexual functions and sexual satisfaction of women who underwent surgical treatment due to gynecologic cancer. Methods: The study sample consisted of 60 women (experimental group n = 30, control group n = 30) with ovarian, endometrial, and cervical cancer. The women in the experimental group received sexual counseling according to PLISSIT, while the women in the control group were not given sexual counseling but were monitored through routine follow-up. The Female Sexual Function Index (FSFI) and the Sexual Satisfaction Scale for Women (SSS-W) were used for the first and last evaluations of the groups. Results: The mean age of the women in the experimental group was 51.87 ± 8.89, while it was 50.47 ± 9.43 in the control group. There was no significant difference between the two groups in terms of sexual function and sexual satisfaction levels in the first evaluation (p>.05), whereas there was a significant difference between the two groups in the final evaluation after the sexual counseling provided to the experimental group (p < .001). When the first and final evaluations of the women were considered, it was observed that 33.3% of the women in the experimental group had adequate sexual functioning in the final evaluation. Conclusion: The sexual counseling carried out using the PLISSIT model for women who were treated for gynecologic cancer positively affected their sexual function and sexual satisfaction levels.
目的:探讨性咨询对妇科癌症手术患者性功能和性满意度的影响。方法:研究样本包括60名患有卵巢癌、子宫内膜癌和宫颈癌的女性(实验组n=30,对照组n=30)。实验组的女性根据PLISSIT接受了性咨询,而对照组的女性没有接受性咨询,而是通过常规随访进行监测。女性性功能指数(FSFI)和女性性满意度量表(SSS-W)用于对各组的第一次和最后一次评估。结果:实验组女性平均年龄为51.87±8.89岁,对照组为50.47±9.43岁。在第一次评估中,两组在性功能和性满意度方面没有显著差异(p>0.05),而在向实验组提供性咨询后的最终评估中,这两组之间有显著差异(p<0.01),观察到实验组中33.3%的女性在最终评估中具有足够的性功能。结论:应用PLISSIT模型对妇科癌症患者进行性咨询,对其性功能和性满意度有积极影响。
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引用次数: 0
Awareness of Infectious Disease Risks and Vaccination Behaviors Among Health Professionals 卫生专业人员传染病风险意识与疫苗接种行为
IF 0.2 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2023-04-15 DOI: 10.33808/clinexphealthsci.959620
Ö. Oruç, D. Yıldırım, V. Kocatepe, İnsaf Demi̇rkiran
Objective: This study aims to evaluate the awareness of infectious disease risks and vaccination behaviors of health professionals. Methods: This descriptive and cross-sectional study was conducted who worked at a research and training hospital, met the inclusion criteria and agreed to participate. Personal information form and Communicable Diseases Risk Awareness Protection Scale (CDRAPS) were used for data collection. The study was completed with 208 health professionals actively working at the hospital. Personal information form and communicable diseases risk awareness and protection scale were collected. Results: In this study, 62% of the participants have had influenza before and 85.1% were vaccinated with at least one of the adult vaccines. 10.6%were formerly vaccinated with pneumococcal vaccine and half of them were vaccinated during the COVID-19. 16.8% of the participants, who were not formerly vaccinated with influenza vaccine, stated their intentions to receive vaccine, 90% decided during the pandemic. Mean CDRAPS score was 155.70±15.47. There was statistically significant relationship between the knowledge of the participants on adult vaccines and the mean scores obtained from the CDRAPS (p=.004) and between the decision to receive influenza vaccination and the CDRAPS scores (p=.047). Conclusion: There was a statistically significant relationship between knowledge on adult vaccines, plans to receive influenza vaccination and the scores obtained from the CDRAPS.
目的:了解卫生专业人员传染病风险意识及预防接种行为。方法:本研究为描述性横断面研究,研究对象为在某研究培训医院工作、符合纳入标准并同意参与的患者。数据收集采用个人信息表和传染病风险意识保护量表(CDRAPS)。该研究由208名在医院积极工作的卫生专业人员完成。收集个人信息表和传染病风险意识与防护量表。结果:在本研究中,62%的参与者以前患过流感,85.1%的人接种过至少一种成人疫苗。10.6%的人以前接种过肺炎球菌疫苗,其中一半在COVID-19期间接种过疫苗。以前未接种流感疫苗的参与者中有16.8%表示有意接种疫苗,其中90%是在大流行期间决定接种的。平均CDRAPS评分为155.70±15.47分。参与者对成人疫苗的了解程度与从CDRAPS获得的平均得分之间存在统计学显著关系(p= 0.004),接受流感疫苗接种的决定与CDRAPS得分之间存在统计学显著关系(p= 0.047)。结论:成人疫苗知识、流感疫苗接种计划与CDRAPS评分之间存在显著的相关关系。
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引用次数: 0
Surface Plasmon Resonance Binding Study on the Interaction of Acetazolamide and Bovine Serum Albumin 乙酰唑胺与牛血清白蛋白相互作用的表面等离子体共振结合研究
IF 0.2 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2023-04-11 DOI: 10.33808/clinexphealthsci.1218956
Emir Alper Türkoğlu, Fatma Gülruy Aydin
Objective: Serum albumins are major plasma proteins in systemic blood circulation and act as transport proteins for endogenous and exogenous compounds such as drugs. In pharmaceutical applications, it is essential to characterize how drugs bind to serum albumin in the evaluation of drug candidates. Surface plasmon resonance (SPR) is fast, real-time, label-free optical based detection technique that offers the monitoring of molecular interactions, analyzing binding reactions and determining the affinity constants with real-time and high sensitivity. Acetazolamide (AZA) is used in the treatment of epilepsy and glaucoma. Methods: To determine the binding kinetics of AZA-Bovine serum albumin (BSA) interaction, (i) SPR gold sensor surface was functionalized, (ii) amine coupling procedure was applied to activate the surface group and BSA was immobilized on functionalized sensor surface, (iii) the concentration series of AZA (10, 25, 50, 75, 100, 150, 200 and 250 µM) was injected to SPR system and (iv) kinetic values were measured using the software of SPR system. Results: 5 mM MUA was coated for surface functionalization. 250 µg/mL BSA as ligand, 30 µL/min flow rate, 1X PBS buffer (pH 7.4) and 10 mM acetate buffer (pH 5.2) as running and coupling buffers, respectively, were performed for SPR binding study. According to result, equilibrium constant (KD) of AZA-BSA was determined as 67.72 µM. Conclusion: In this study, we investigated the AZA-BSA binding interaction using SPR system based on Kretchmann configuration. The study designed with fast, label-free and real-time approach will provide valuable knowledge for pharmaceutical and clinical applications.
目的:血清白蛋白是体循环中主要的血浆蛋白,是内源性和外源性化合物(如药物)的转运蛋白。在制药应用中,在评估候选药物时,表征药物如何与血清白蛋白结合是至关重要的。表面等离子体共振(SPR)是一种快速、实时、无标记的基于光学的检测技术,可以实时、高灵敏度地监测分子相互作用、分析结合反应和确定亲和常数。乙酰唑胺(AZA)用于治疗癫痫和青光眼。方法:为确定AZA-牛血清白蛋白(BSA)相互作用的结合动力学,(i)将SPR金传感器表面功能化,(ii)采用胺偶联程序激活表面基团,将BSA固定在功能化的传感器表面,(iii)将AZA的浓度系列(10、25、50、75、100、150、200和250µM)注射到SPR系统中,(iv)利用SPR系统软件测量动力学值。结果:5 mM MUA包被表面功能化。以250µg/mL BSA为配体,流速为30µL/min, 1X PBS缓冲液(pH 7.4)和10 mM乙酸缓冲液(pH 5.2)分别作为运行缓冲液和偶联缓冲液进行SPR结合研究。结果表明,AZA-BSA的平衡常数(KD)为67.72µM。结论:本研究利用基于Kretchmann构型的SPR体系研究了AZA-BSA的结合相互作用。该研究采用快速、无标签和实时的方法设计,将为制药和临床应用提供有价值的知识。
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引用次数: 0
Hyaluronic Acid-Curcumin Complex Triggers Apoptotic Pathway in Breast Cancer Cells via CD44 Receptors 透明质酸-姜黄素复合物通过CD44受体触发乳腺癌细胞凋亡通路
IF 0.2 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2023-04-07 DOI: 10.33808/clinexphealthsci.1185564
Ziba Mokhberi̇oskouei̇, Gökhan Biçim, A. Yılmaz, A. Yalçın
Objective: Curcumin (CUR) was modified with hyaluronic acid (HA) to increase its water solubility and bioavailability. Our aim was to increase the uptake of CUR into the cells that express CD44 receptors and to compare the cellular effects in two different human breast carcinoma cells, MCF-7 and MDA-MB-231. Methods: Hyaluronic acid-curcumin complex (HA-CUR) was synthesized and characterized. MCF-7 and MDA-MB-231 cells were grown under appropriate conditions and the effect of CUR and HA-CUR on cell viability was determined. Apoptosis levels of cells after treatment with CUR and HA-CUR were also measured. CD44 receptor levels of both cells were compared and then apoptosis levels were measured in MDA-MB-231 cells after saturation of CD 44 receptors with HA. In both cells expression of caspase-9 and PARP was analyzed to confirm apoptosis. Results: In MCF-7 cells, the percentage apoptosis level of the CUR group was slightly lower than the HA-CUR group. In MDA-MB-231 cells, no statistically significant difference was found in the CUR group compared to the control group, but the apoptosis level of the HA-CUR group was higher than the control group. CD44 receptor levels were higher in MDA-MB-231 cells compared to MCF-7 cells. Blocking the CD44 receptors reversed the apoptotic effect of HA-CUR in MDA-MB-231 cells. Both CUR and HA-CUR had apoptotic effects in MCF-7 and MDA-MB-231 cells. Conclusion: Conjugation of CUR with HA, which is specific for CD44 receptors aids, in its entry to target cells making it a powerful agent for targeted cancer therapy.
目的:用透明质酸(HA)修饰姜黄素(CUR),提高其水溶性和生物利用度。我们的目的是增加CUR对表达CD44受体的细胞的摄取,并比较两种不同的人类乳腺癌细胞MCF-7和MDA-MB-231的细胞效应。方法:合成透明质酸-姜黄素复合物(HA-CUR)并对其进行表征。MCF-7和MDA-MB-231细胞在适当的条件下生长,并测定CUR和HA-CUR对细胞活力的影响。还测定了用CUR和HA-CUR处理后细胞的凋亡水平。比较两种细胞的CD44受体水平,然后在用HA饱和CD44受体后测量MDA-MB-231细胞中的凋亡水平。分析两种细胞中胱天蛋白酶-9和PARP的表达以证实细胞凋亡。结果:在MCF-7细胞中,CUR组的细胞凋亡率略低于HA-CUR组。在MDA-MB-231细胞中,与对照组相比,CUR组没有发现统计学上的显著差异,但HA-CUR组的凋亡水平高于对照组。与MCF-7细胞相比,MDA-MB-231细胞中CD44受体水平更高。阻断CD44受体逆转了HA-CUR在MDA-MB-231细胞中的凋亡作用。CUR和HA-CUR均对MCF-7和MDA-MB-231细胞具有凋亡作用。结论:CUR与对CD44受体具有特异性的HA结合有助于其进入靶细胞,使其成为癌症靶向治疗的有力药物。
{"title":"Hyaluronic Acid-Curcumin Complex Triggers Apoptotic Pathway in Breast Cancer Cells via CD44 Receptors","authors":"Ziba Mokhberi̇oskouei̇, Gökhan Biçim, A. Yılmaz, A. Yalçın","doi":"10.33808/clinexphealthsci.1185564","DOIUrl":"https://doi.org/10.33808/clinexphealthsci.1185564","url":null,"abstract":"Objective: Curcumin (CUR) was modified with hyaluronic acid (HA) to increase its water solubility and bioavailability. Our aim was to increase the uptake of CUR into the cells that express CD44 receptors and to compare the cellular effects in two different human breast carcinoma cells, MCF-7 and MDA-MB-231. \u0000Methods: Hyaluronic acid-curcumin complex (HA-CUR) was synthesized and characterized. \u0000MCF-7 and MDA-MB-231 cells were grown under appropriate conditions and the effect of CUR and HA-CUR on cell viability was determined. Apoptosis levels of cells after treatment with CUR and HA-CUR were also measured. CD44 receptor levels of both cells were compared and then apoptosis levels were measured in MDA-MB-231 cells after saturation of CD 44 receptors with HA. In both cells expression of caspase-9 and PARP was analyzed to confirm apoptosis. \u0000Results: In MCF-7 cells, the percentage apoptosis level of the CUR group was slightly lower than the HA-CUR group. In MDA-MB-231 cells, no statistically significant difference was found in the CUR group compared to the control group, but the apoptosis level of the HA-CUR group was higher than the control group. CD44 receptor levels were higher in MDA-MB-231 cells compared to MCF-7 cells. Blocking the CD44 receptors reversed the apoptotic effect of HA-CUR in MDA-MB-231 cells. Both CUR and HA-CUR had apoptotic effects in MCF-7 and MDA-MB-231 cells. \u0000Conclusion: Conjugation of CUR with HA, which is specific for CD44 receptors aids, in its entry to target cells making it a powerful agent for targeted cancer therapy.","PeriodicalId":10192,"journal":{"name":"Clinical and Experimental Health Sciences","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49175721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phytochemical, Pharmacological, and Toxicological Studies on Peganum harmala L.: An Overview of the Last Decade 骆驼蓬的植物化学、药理学和毒理学研究:近十年综述
IF 0.2 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2023-04-04 DOI: 10.33808/clinexphealthsci.1125345
İçim Gökkaya, Gülin Renda, Tuğba Subaş, U. Özgen
Objective: Plants have been used to treat ailments since the dawn of humanity. The use of medicinal plants for various purposes such as preventing diseases, treating diseases and supporting medical treatment is increasing day by day. On the other hand, medicinal plants are important sources of raw materials for the pharmaceutical industry. It has been demonstrated that Peganum harmala L. and the phytochemicals it contains have a wide variety of pharmacological activities. P. harmala and its active ingredients can be an important resource for the pharmaceutical industry. In this review, the phytochemistry, pharmacological effects, clinical studies, and toxicity of P. harmala are discussed under the current information. Methods: Studies on P. harmala were searched using Pubmed, Scopus, Science Direct databases, and Google Scholar search engine. As a result of the searches, 96 articles were included in the study. Results: The main group of secondary metabolites responsible for the biological activities of P. harmala is alkaloids. The plant and its isolated secondary plant compounds have been shown to have many pharmacological actions, counting antiamnestic, anticancer, antidepressant, antiinflammatory, cardiovascular, gastroprotective, hepatoprotective, nephroprotective, and vasodilator activities. Studies evaluating the plant's clinical effects have been carried out in recent years. However, it has been recorded in the literature that the use of P. harmala causes poisoning with symptoms such as neurosensory symptoms, visual hallucination, bradycardia, hypotension, agitation, tremor, ataxia, and vomiting. Conclusion: Considering the pharmacological effects, the number of studies on the efficacy and safety of P. harmala and its secondary metabolites should be increased.
目的:自人类诞生以来,植物就被用于治疗疾病。药用植物用于预防疾病、治疗疾病和支持医疗等各种目的的用途日益增加。另一方面,药用植物是制药工业的重要原料来源。研究表明,骆驼蓬及其所含的植物化学物质具有多种药理活性。骆驼蓬及其有效成分是医药工业的重要资源。本文就骆驼蓬的植物化学、药理作用、临床研究和毒性等方面进行了综述。方法:利用Pubmed、Scopus、Science Direct数据库和Google Scholar搜索引擎对骆驼蓬的研究进行检索。搜索的结果是,研究中包含了96篇文章。结果:骆驼蓬生物活性的主要次生代谢产物为生物碱。该植物及其分离的次生植物化合物已被证明具有许多药理作用,包括抗记忆、抗癌、抗抑郁、抗炎、心血管、胃保护、肝保护、肾保护和血管舒张活性。近年来,人们对这种植物的临床效果进行了评估研究。然而,文献中记载,使用骆驼蓬会导致中毒,症状包括神经感觉症状、幻觉、心动过缓、低血压、躁动、震颤、共济失调和呕吐。结论:考虑到药理作用,应增加对骆驼蓬及其次级代谢产物的疗效和安全性的研究数量。
{"title":"Phytochemical, Pharmacological, and Toxicological Studies on Peganum harmala L.: An Overview of the Last Decade","authors":"İçim Gökkaya, Gülin Renda, Tuğba Subaş, U. Özgen","doi":"10.33808/clinexphealthsci.1125345","DOIUrl":"https://doi.org/10.33808/clinexphealthsci.1125345","url":null,"abstract":"Objective: Plants have been used to treat ailments since the dawn of humanity. The use of medicinal plants for various purposes such as preventing diseases, treating diseases and supporting medical treatment is increasing day by day. On the other hand, medicinal plants are important sources of raw materials for the pharmaceutical industry. It has been demonstrated that Peganum harmala L. and the phytochemicals it contains have a wide variety of pharmacological activities. P. harmala and its active ingredients can be an important resource for the pharmaceutical industry. In this review, the phytochemistry, pharmacological effects, clinical studies, and toxicity of P. harmala are discussed under the current information. \u0000Methods: Studies on P. harmala were searched using Pubmed, Scopus, Science Direct databases, and Google Scholar search engine. As a result of the searches, 96 articles were included in the study. \u0000Results: The main group of secondary metabolites responsible for the biological activities of P. harmala is alkaloids. The plant and its isolated secondary plant compounds have been shown to have many pharmacological actions, counting antiamnestic, anticancer, antidepressant, antiinflammatory, cardiovascular, gastroprotective, hepatoprotective, nephroprotective, and vasodilator activities. Studies evaluating the plant's clinical effects have been carried out in recent years. However, it has been recorded in the literature that the use of P. harmala causes poisoning with symptoms such as neurosensory symptoms, visual hallucination, bradycardia, hypotension, agitation, tremor, ataxia, and vomiting. Conclusion: Considering the pharmacological effects, the number of studies on the efficacy and safety of P. harmala and its secondary metabolites should be increased.","PeriodicalId":10192,"journal":{"name":"Clinical and Experimental Health Sciences","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43395364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Clinical and Experimental Health Sciences
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