Pub Date : 2023-02-06DOI: 10.33808/clinexphealthsci.1239176
C. Nacar
Objective: The frequencies of amino acids in proteins for different structural levels have been determined by many studies. However, due to the different content of data sets, findings from these studies are inconsistent for some amino acids. This study aims to eliminate the contradictions in the findings of the studies by determining the frequencies of the amino acids in all structural level of globular proteins. Methods: The frequencies of the amino acids in overall protein, in secondary structural elements (helix, sheet, coil) and in subtypes of secondary structural elements (α-, π-, and 310-helices, and first, parallel and anti-parallel strands) were calculated separately using a data set including 4.882 dissimilar globular peptides. The frequencies of the amino acids were calculated as the ratio of the total number of a specific residue in related structure to the total number of all residues in the related structure. Results: The frequencies of residues determined in this study is partially in consistent with the other studies. The differences are probably due to the data set contents of the studies. The frequencies of the amino acids in subtypes of secondary structural elements were determined for the first time in this study. Conclusions: Variations in the frequencies of PRO residue in 310-helix structure and of ILE, LEU, and VAL residues in strands of sheet structure are valuable findings for the improvement of secondary structure prediction methods, as they can be used as secondary structural elements markers.
{"title":"The Frequencies of Amino Acids in Secondary Structural Elements of Globular Proteins","authors":"C. Nacar","doi":"10.33808/clinexphealthsci.1239176","DOIUrl":"https://doi.org/10.33808/clinexphealthsci.1239176","url":null,"abstract":"Objective: The frequencies of amino acids in proteins for different structural levels have been determined by many studies. However, due to the different content of data sets, findings from these studies are inconsistent for some amino acids. This study aims to eliminate the contradictions in the findings of the studies by determining the frequencies of the amino acids in all structural level of globular proteins. \u0000Methods: The frequencies of the amino acids in overall protein, in secondary structural elements (helix, sheet, coil) and in subtypes of secondary structural elements (α-, π-, and 310-helices, and first, parallel and anti-parallel strands) were calculated separately using a data set including 4.882 dissimilar globular peptides. The frequencies of the amino acids were calculated as the ratio of the total number of a specific residue in related structure to the total number of all residues in the related structure. \u0000Results: The frequencies of residues determined in this study is partially in consistent with the other studies. The differences are probably due to the data set contents of the studies. The frequencies of the amino acids in subtypes of secondary structural elements were determined for the first time in this study. \u0000Conclusions: Variations in the frequencies of PRO residue in 310-helix structure and of ILE, LEU, and VAL residues in strands of sheet structure are valuable findings for the improvement of secondary structure prediction methods, as they can be used as secondary structural elements markers.","PeriodicalId":10192,"journal":{"name":"Clinical and Experimental Health Sciences","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45716083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-02-06DOI: 10.33808/clinexphealthsci.1198077
E. İzgi, Filiz Mediha NAMDAR PEKİNER
Objective: The purpose of this study is to apply Demirjian’s and Willems’ methodologies and to define whether there are any discrepancies in predicting dental age versus chronological age in a sample Turkish Caucasian children. Methods: A total of 150 Turkish Caucasian children with known chronological age and gender were chosen. The chronological age was determined by subtracting the date of birth from the date of the radiograph, and it was expressed as a number with two decimal places. Each age group was determined to have a minimum sample size of 12 and a maximum sample size of 27. All panoramic radiographs were scored according to the criteria of Demirjian’s and Willems methodologies with Onyx Ceph 3.1.54 software. Results: The dental ages of the cases ranged from 4.82 to 15.66 years calculated by the Demirjian’s method, with an average of 9.47±2.27 years, while the Willems method of the cases ranged from 4.13 to 14.34 years calculated by the Demirjian’s method, with an average of 8.87±2.24 years. According to Demirjian’s method, in the developmental evaluation of dental age, 45.3% of boys were found to have a statistically higher chronological age than girls (p.05). Conclusion: The Willems method was shown to be more accurate in determining dental age in Turkish children. Further studies on large population groups and diverse ethnicities are required to increase the reliability and repeatability of the results.
{"title":"Accuracy of Dental and Chronological Age Estimation in A Sample Turkish Caucasion Children:Comparison of Demirjian’s and Willems Methods","authors":"E. İzgi, Filiz Mediha NAMDAR PEKİNER","doi":"10.33808/clinexphealthsci.1198077","DOIUrl":"https://doi.org/10.33808/clinexphealthsci.1198077","url":null,"abstract":"Objective: The purpose of this study is to apply Demirjian’s and Willems’ methodologies and to define whether there are any discrepancies in \u0000predicting dental age versus chronological age in a sample Turkish Caucasian children. \u0000Methods: A total of 150 Turkish Caucasian children with known chronological age and gender were chosen. The chronological age was determined by subtracting the date of birth from the date of the radiograph, and it was expressed as a number with two decimal places. Each age group was determined to have a minimum sample size of 12 and a maximum sample size of 27. All panoramic radiographs were scored according to the criteria of Demirjian’s and Willems methodologies with Onyx Ceph 3.1.54 software. \u0000Results: The dental ages of the cases ranged from 4.82 to 15.66 years calculated by the Demirjian’s method, with an average of 9.47±2.27 years, while the Willems method of the cases ranged from 4.13 to 14.34 years calculated by the Demirjian’s method, with an average of 8.87±2.24 years. According to Demirjian’s method, in the developmental evaluation of dental age, 45.3% of boys were found to have a statistically higher chronological age than girls (p.05). \u0000Conclusion: The Willems method was shown to be more accurate in determining dental age in Turkish children. Further studies on large population groups and diverse ethnicities are required to increase the reliability and repeatability of the results.","PeriodicalId":10192,"journal":{"name":"Clinical and Experimental Health Sciences","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42315482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-02-06DOI: 10.33808/clinexphealthsci.1194836
Habibe Öztürk, Y. Deniz, Çağatay Aktaş, Esma Başak GÜL AYGÜN
Objective: This study aimed to assess the effects of denture materials on dose distribution on a head and neck radiotherapy-appropriate model and calculate the thickness of a stent by polyvinyl siloxane dental impression material for shielding scattered radiation from dental restorations. Methods: In the first step of the study, 5mm diameter and 5mm height of cylindrical dental material of titanium, zirconia lithium disilicate were irradiated with 6-Megavoltage photons from a clinical linear accelerator. In the second step, dental materials at the center of polyvinyl siloxane thicknesses of 5, 10, and 20mm were irradiated with 2 Gray and 10 Gray fractional doses. Measurements were made using three thermoluminescent dosimeters positioned laterally. The percentage backscattered dose and percentage dose decrease values were calculated to interpret the results. Results: According to the result, dosages scattered from dental materials increased for samples irradiated with 2Gy; a decreased dose was reported for samples irradiated with a 10Gy. 5mm PVS samples provided higher dose attenuation than others. Regardless of dental material, it is seen that the attenuation intensities calculated from TLD-100 dosimeters ranged from 22.7 to 38,62 for 2Gy, and 10.01 to 38,87 for 10Gy. Conclusion: Dental material alters the scattered radiation. In irradiated head and neck cancer patients, a 5mm thick guard is sufficient to prevent radiation diffused from dental materials in clinical usage.
{"title":"Investigation of Dosage Distributions of Polyvinyl Siloxane Dental Impression Shields for Head and Neck Radiotherapy with Thermoluminances Dosimeters","authors":"Habibe Öztürk, Y. Deniz, Çağatay Aktaş, Esma Başak GÜL AYGÜN","doi":"10.33808/clinexphealthsci.1194836","DOIUrl":"https://doi.org/10.33808/clinexphealthsci.1194836","url":null,"abstract":"Objective: This study aimed to assess the effects of denture materials on dose distribution on a head and neck radiotherapy-appropriate model and calculate the thickness of a stent by polyvinyl siloxane dental impression material for shielding scattered radiation from dental restorations. \u0000Methods: In the first step of the study, 5mm diameter and 5mm height of cylindrical dental material of titanium, zirconia lithium disilicate were irradiated with 6-Megavoltage photons from a clinical linear accelerator. In the second step, dental materials at the center of polyvinyl siloxane thicknesses of 5, 10, and 20mm were irradiated with 2 Gray and 10 Gray fractional doses. Measurements were made using three thermoluminescent dosimeters positioned laterally. The percentage backscattered dose and percentage dose decrease values were calculated to interpret the results. \u0000Results: According to the result, dosages scattered from dental materials increased for samples irradiated with 2Gy; a decreased dose was reported for samples irradiated with a 10Gy. 5mm PVS samples provided higher dose attenuation than others. Regardless of dental material, it is seen that the attenuation intensities calculated from TLD-100 dosimeters ranged from 22.7 to 38,62 for 2Gy, and 10.01 to 38,87 for 10Gy. \u0000Conclusion: Dental material alters the scattered radiation. In irradiated head and neck cancer patients, a 5mm thick guard is sufficient to prevent radiation diffused from dental materials in clinical usage.","PeriodicalId":10192,"journal":{"name":"Clinical and Experimental Health Sciences","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48016909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-02-01DOI: 10.33808/clinexphealthsci.927643
Sema Aytaç, Ö. Ovayolu, Sibel Serçe, N. Ovayolu
Objective: The prevalence of geriatric cancer disease is gradually increasing. Both the cancer diagnosis and many accompanying symptoms affect individuals bio-psycho-socially and impair the quality of life. This study was conducted to evaluate pain and nutritional status in geriatric cancer patients. Methods: This descriptive study was conducted with geriatric cancer patients receiving treatment in the ambulatory chemotherapy outpatient clinic of a university and oncology hospital. The population of the study consisted of cancer patients receiving treatment in the hospital and the sample consisted of 215 geriatric cancer patients who were voluntary to participate in the study. The data of the study were collected using a questionnaire, the Visual Analog Scale (VAS), and the Mini Nutritional Assessment. Results: The mean age of the patients was 69.3±4.7 years. Respiratory tract cancers ranked first (28.8%). 42.8% of the patients were at stage four and they frequently experienced symptoms such as fatigue, loss of appetite and poor nutrition. VAS mean score was 4.8±2.8, Mini nutritional assessment mean score was 9.2±3.0, and there was a negative significant correlation between the VAS and Mini nutritional assessment mean scores (p
{"title":"Pain and Malnutrition in Elderly Cancer Patients: Examples of Southern Turkey","authors":"Sema Aytaç, Ö. Ovayolu, Sibel Serçe, N. Ovayolu","doi":"10.33808/clinexphealthsci.927643","DOIUrl":"https://doi.org/10.33808/clinexphealthsci.927643","url":null,"abstract":"Objective: The prevalence of geriatric cancer disease is gradually increasing. Both the cancer diagnosis and many accompanying symptoms affect individuals bio-psycho-socially and impair the quality of life. This study was conducted to evaluate pain and nutritional status in geriatric cancer patients. \u0000Methods: This descriptive study was conducted with geriatric cancer patients receiving treatment in the ambulatory chemotherapy outpatient clinic of a university and oncology hospital. The population of the study consisted of cancer patients receiving treatment in the hospital and the sample consisted of 215 geriatric cancer patients who were voluntary to participate in the study. The data of the study were collected using a questionnaire, the Visual Analog Scale (VAS), and the Mini Nutritional Assessment. \u0000Results: The mean age of the patients was 69.3±4.7 years. Respiratory tract cancers ranked first (28.8%). 42.8% of the patients were at stage four and they frequently experienced symptoms such as fatigue, loss of appetite and poor nutrition. VAS mean score was 4.8±2.8, Mini nutritional assessment mean score was 9.2±3.0, and there was a negative significant correlation between the VAS and Mini nutritional assessment mean scores (p","PeriodicalId":10192,"journal":{"name":"Clinical and Experimental Health Sciences","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46184911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-02-01DOI: 10.33808/clinexphealthsci.1164952
Tugce Sönmez, Serap EJDER APAY
Objective: This study aimed to determine the effectiveness of different birth balls used at the first stage of labor on fetal head descent, pain intensity, and maternal satisfaction. Methods: This study used a single-blind, randomized controlled experimental design. It was conducted with 180 primipara women in a maternity hospital in Erzurum, Turkey between October 2018 and December 2019. Women were randomized into 3 groups: A=Control group (n=60), B=Spherical birth ball group (n=60), and C=Peanut ball group (n=60). Birth balls were initiated in the active phase in the first stage of labor when cervical dilatation was 4 cm. Data were collected using the Personal Information Form, the Visual Analogue Scale (VAS), the Verbal Rating Scale (VRS), Partograph, and the Scale for Measuring Maternal Satisfaction in Birth (SMMSB). Results: In the active and transitional phases of labor, the VAS and VRS scores for labor pain perception of Group B were statistically significantly lower than the scores of Group A and C (p
{"title":"Effect of Different Birth Balls Used at the First Stage of Labor on Birth Outcomes and Maternal Satisfaction: A Randomized Controlled Trial","authors":"Tugce Sönmez, Serap EJDER APAY","doi":"10.33808/clinexphealthsci.1164952","DOIUrl":"https://doi.org/10.33808/clinexphealthsci.1164952","url":null,"abstract":"Objective: This study aimed to determine the effectiveness of different birth balls used at the first stage of labor on fetal head descent, pain intensity, and maternal satisfaction. \u0000Methods: This study used a single-blind, randomized controlled experimental design. It was conducted with 180 primipara women in a maternity hospital in Erzurum, Turkey between October 2018 and December 2019. Women were randomized into 3 groups: A=Control group (n=60), B=Spherical birth ball group (n=60), and C=Peanut ball group (n=60). Birth balls were initiated in the active phase in the first stage of labor when cervical dilatation was 4 cm. Data were collected using the Personal Information Form, the Visual Analogue Scale (VAS), the Verbal Rating Scale (VRS), Partograph, and the Scale for Measuring Maternal Satisfaction in Birth (SMMSB). \u0000Results: In the active and transitional phases of labor, the VAS and VRS scores for labor pain perception of Group B were statistically significantly lower than the scores of Group A and C (p","PeriodicalId":10192,"journal":{"name":"Clinical and Experimental Health Sciences","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45499482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-30DOI: 10.33808/clinexphealthsci.976389
Mansooreh Sadat Mojani Qomi, Monireh Hatami, P. Ziarati
Objective: Increasing the incidence of eating disorder (ED) attitude during adolescence may lead to inadequate nutrient intake and consequently to growth disorders. This study aimed to compare eating habits and nutrient intakes of adolescents with high risk and low risk of developing eating disorders in high schools in Tehran, Iran. Methods: In the current cross-sectional study, the Eating Attitude Test (EAT-26) was applied to 299 students (185 females and 114 males) aged 15-18 years for the determination of ED attitudes. Food habits and nutrient intake were assessed by a self-administered questionnaire and a validated Food Frequency Questionnaire (FFQ), respectively. Nutrient adequacy ratio (NAR) and mean adequacy ratio (MAR) were calculated using nutrient’s Dietary Reference Intake (DRI) for age and sex. Results: Of all students, 17.7% were at risk of developing ED. The results showed that girls, unlike boys, consumed more energy than they needed, but this difference between the ED group in both sexes was not significant. The distribution of sweetened drinks, candy, chocolate, and fast food frequency was significantly different between the two groups of girls (P
{"title":"Evaluation of Eating Habits and Nutrient Intake in Adolescents with and without Suspected Eating Disorders in Iran","authors":"Mansooreh Sadat Mojani Qomi, Monireh Hatami, P. Ziarati","doi":"10.33808/clinexphealthsci.976389","DOIUrl":"https://doi.org/10.33808/clinexphealthsci.976389","url":null,"abstract":"Objective: Increasing the incidence of eating disorder (ED) attitude during adolescence may lead to inadequate nutrient intake and consequently to growth disorders. This study aimed to compare eating habits and nutrient intakes of adolescents with high risk and low risk of developing eating disorders in high schools in Tehran, Iran. Methods: In the current cross-sectional study, the Eating Attitude Test (EAT-26) was applied to 299 students (185 females and 114 males) aged 15-18 years for the determination of ED attitudes. Food habits and nutrient intake were assessed by a self-administered questionnaire and a validated Food Frequency Questionnaire (FFQ), respectively. Nutrient adequacy ratio (NAR) and mean adequacy ratio (MAR) were calculated using nutrient’s Dietary Reference Intake (DRI) for age and sex. Results: Of all students, 17.7% were at risk of developing ED. The results showed that girls, unlike boys, consumed more energy than they needed, but this difference between the ED group in both sexes was not significant. The distribution of sweetened drinks, candy, chocolate, and fast food frequency was significantly different between the two groups of girls (P","PeriodicalId":10192,"journal":{"name":"Clinical and Experimental Health Sciences","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43444038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-20DOI: 10.33808/clinexphealthsci.1084321
Tuba Bay, Ilknur Yalcin, Ayşegül Ergün
Objective: Insomnia is an important health problem affecting physical, spiritual and social well-being of individuals negatively and it should be early diagnosed as well. The purpose is to appraise the psychometric features of the Turkish version of the Bergen Insomnia Scale (BIS) for adults. Methods: A total of 495 adults were included in the methodological study in Turkey. Turkish form of BIS was designed within the scope of study conducted in adolescent sample. Construct validity was appraised with exploratory, confirmatory factor analysis, convergent and discriminant validity. Internal-consistency and test-retest analysis were used for reliability. Results: According to results of explanatory, confirmatory factor analysis; it was identified that BIS showed a two-factor structure as daytime symptoms (α=.85) and nocturnal symptoms (α=.80). Item-total correlations were found as ≥.59 and test-retest correlation as .83. Conclusions: The Turkish version of the Bergen Insomnia Scale for adults was assessed as valid and reliable.
{"title":"Bergen Insomnia Scale for Adults: The Psychometric Features of the Turkish Version","authors":"Tuba Bay, Ilknur Yalcin, Ayşegül Ergün","doi":"10.33808/clinexphealthsci.1084321","DOIUrl":"https://doi.org/10.33808/clinexphealthsci.1084321","url":null,"abstract":"Objective: Insomnia is an important health problem affecting physical, spiritual and social well-being of individuals negatively and it should be early diagnosed as well. The purpose is to appraise the psychometric features of the Turkish version of the Bergen Insomnia Scale (BIS) for adults. \u0000Methods: A total of 495 adults were included in the methodological study in Turkey. Turkish form of BIS was designed within the scope of study conducted in adolescent sample. Construct validity was appraised with exploratory, confirmatory factor analysis, convergent and discriminant validity. Internal-consistency and test-retest analysis were used for reliability. \u0000Results: According to results of explanatory, confirmatory factor analysis; it was identified that BIS showed a two-factor structure as daytime symptoms (α=.85) and nocturnal symptoms (α=.80). Item-total correlations were found as ≥.59 and test-retest correlation as .83. \u0000Conclusions: The Turkish version of the Bergen Insomnia Scale for adults was assessed as valid and reliable.","PeriodicalId":10192,"journal":{"name":"Clinical and Experimental Health Sciences","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43887711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-19DOI: 10.33808/clinexphealthsci.1036048
E. Çikler, İ. Söğüt, Sezen Gizem Aydoğan, Seda Kırmızıkan, C. Hürdağ
Objective: Chronic stress plays an important role in the etiology of many inflammatory diseases. Reactive oxygen species (ROS), a source of free radicals, act as signaling molecules in the progression of stress-related inflammatory diseases. Oxidative stress occurs as a result of an increase in free radicals in the tissues. The damage caused by oxidative stress can be reduced by antioxidant replacement. In our study, the effect of fulvic acid, a powerful antioxidant, on the damage caused by the water avoidance stress model in the rat colon was investigated morphologically and biochemically. Methods: Experimental groups (n=6, Sprague-Dawley male rats, 300 g): control (C), water avoidance stress (WAS), and water avoidance stress+fulvic acid (WAS+FA). Rats in the WAS + FA group were given a single dose of FA (150 mg/kg i.p.) immediately after exposure to water avoidance stress. The colons were stained with hematoxylin-eosin and toluidine blue. Total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) were analyzed biochemically. Results: Compared to the C group, the WAS group showed epithelial damage, a few empty goblet cells, inflammatory cell infiltration, and many active mast cells in the connective tissue. Mucosal integrity, the number of goblet cells, and mast cell activity improved in the WAS+FA group as compared to the WAS group. Biochemically, as compared to the C group, TAS levels decreased, and TOS and OSI levels increased in the WAS group. In the WAS+FA group, TAS levels increased, and TOS and OSI levels decreased with respect to those in the WAS group. Conclusion: Our findings indicated that fulvic acid reduced the damage caused by chronic oxidative stress in the colon.
{"title":"The Effects of Fulvic Acid Against Water Avoidance Stress-Induced Damage of Rat Colon Mucosa","authors":"E. Çikler, İ. Söğüt, Sezen Gizem Aydoğan, Seda Kırmızıkan, C. Hürdağ","doi":"10.33808/clinexphealthsci.1036048","DOIUrl":"https://doi.org/10.33808/clinexphealthsci.1036048","url":null,"abstract":"Objective: Chronic stress plays an important role in the etiology of many inflammatory diseases. Reactive oxygen species (ROS), a source of free radicals, act as signaling molecules in the progression of stress-related inflammatory diseases. Oxidative stress occurs as a result of an increase in free radicals in the tissues. The damage caused by oxidative stress can be reduced by antioxidant replacement. In our study, the effect of fulvic acid, a powerful antioxidant, on the damage caused by the water avoidance stress model in the rat colon was investigated morphologically and biochemically. \u0000Methods: Experimental groups (n=6, Sprague-Dawley male rats, 300 g): control (C), water avoidance stress (WAS), and water avoidance stress+fulvic acid (WAS+FA). Rats in the WAS + FA group were given a single dose of FA (150 mg/kg i.p.) immediately after exposure to water avoidance stress. The colons were stained with hematoxylin-eosin and toluidine blue. Total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) were analyzed biochemically. \u0000Results: Compared to the C group, the WAS group showed epithelial damage, a few empty goblet cells, inflammatory cell infiltration, and many active mast cells in the connective tissue. Mucosal integrity, the number of goblet cells, and mast cell activity improved in the WAS+FA group as compared to the WAS group. Biochemically, as compared to the C group, TAS levels decreased, and TOS and OSI levels increased in the WAS group. In the WAS+FA group, TAS levels increased, and TOS and OSI levels decreased with respect to those in the WAS group. \u0000Conclusion: Our findings indicated that fulvic acid reduced the damage caused by chronic oxidative stress in the colon.","PeriodicalId":10192,"journal":{"name":"Clinical and Experimental Health Sciences","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42529626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: With the widespread use of CAD/CAM (computer aided design and manufacture) systems in dentistry, many restorative materials have been produced. In our study, we aimed to evaluate the change in optical properties of newly developed translucent monolithic zirconia (TMZ) (Cercon HT Dentsply, Sirona, USA), zirconia-reinforced lithium silicate (ZLS) (Celtra Duo, Dentsply, Germany) and lithium disilicate (LS2) (IPS e.max CAD, Ivoclar Vivadent, Liechtenstein) materials with aging. Methods:10 discs of 12mm diameter and 1.2 mm thickness were produced from high translucent A2 color of each material. The aging process was applied in an autoclave under 134ºC, 0.2MPa pressure. For optical evaluation, L*, a*, b* values of the samples were measured by spectrophotometry before aging, after 3 hours and 6 hours aging. ΔE00 values and translucency parameters (TP) were calculated. The data were evaluated statistically. Results: In the present study, all the materials had undergone color change as a result of aging, but this change was within acceptable limits (ΔE00 0.8). There was a decrease in the translucency of all materials used in the study, but this decrease was not statistically significant. Conclusion: In the light of the findings obtained from this in vitro study, aging did not cause color and translucency changes in TMZ, ZLS, LS2 monolithic CAD/CAM materials.
{"title":"Optical Properties of Newly Developed Monolithic CAD/CAM Materials After Aging","authors":"Hatice Banu UYSAL ÖZEL, Yılmaz Umut Aslan, Erkan Sancakli","doi":"10.33808/clinexphealthsci.1185717","DOIUrl":"https://doi.org/10.33808/clinexphealthsci.1185717","url":null,"abstract":"Objective: With the widespread use of CAD/CAM (computer aided design and manufacture) systems in dentistry, many restorative materials have been produced. In our study, we aimed to evaluate the change in optical properties of newly developed translucent monolithic zirconia (TMZ) (Cercon HT Dentsply, Sirona, USA), zirconia-reinforced lithium silicate (ZLS) (Celtra Duo, Dentsply, Germany) and lithium disilicate (LS2) (IPS e.max CAD, Ivoclar Vivadent, Liechtenstein) materials with aging. \u0000Methods:10 discs of 12mm diameter and 1.2 mm thickness were produced from high translucent A2 color of each material. The aging process was applied in an autoclave under 134ºC, 0.2MPa pressure. For optical evaluation, L*, a*, b* values of the samples were measured by spectrophotometry before aging, after 3 hours and 6 hours aging. ΔE00 values and translucency parameters (TP) were calculated. The data were evaluated statistically. \u0000Results: In the present study, all the materials had undergone color change as a result of aging, but this change was within acceptable limits (ΔE00 0.8). There was a decrease in the translucency of all materials used in the study, but this decrease was not statistically significant. \u0000Conclusion: In the light of the findings obtained from this in vitro study, aging did not cause color and translucency changes in TMZ, ZLS, LS2 monolithic CAD/CAM materials.","PeriodicalId":10192,"journal":{"name":"Clinical and Experimental Health Sciences","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41599528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-10DOI: 10.33808/clinexphealthsci.1109246
A. Yaşar, Ö. Yılmaz, H. Yuksel
Introduction Allergic rhinitis is the most common form of non-infectious rhinitis and is manifested with the symptoms of nasal congestion, sneezing, nasal discharge, and itching. Primary enuresis nocturna is involuntary urination while asleep after five years, at which bladder control usually begins. Our objective was to evaluate the relationship between allergic rhinitis and primary enuresis nocturna in childhood in this research. Methods: We included 300 children with allergic rhinitis and 300 control cases between the age of 5 and 17 years. With allergic rhinitis cases, age, gender, body mass index percentile, other allergic disorders, allergic rhinitis diagnosis age, allergic rhinitis severity and distribution, presence of primary enuresis nocturna, and presence of primary enuresis nocturna in the family were recorded. Subjects with disorders causing enuresis were excluded from the study. Results: The mean age in the allergic rhinitis and control groups was 9,6±3,4 vs. 10,0±3,1 years, respectively (p=0,15). There was no statistical difference between the two groups in terms of gender, age, body mass index percentile, and primary enuresis nocturna presence in the family (p=0.29, p=0.15, p=0.46, p=0.17; respectively). Primary enuresis nocturna was significantly higher in allergic rhinitis cases (p=0.02). Primary enuresis nocturna was significantly higher in boys than in girls (p=0.007). There is a significant difference in age and gender between those with and without primary enuresis nocturna in allergic rhinitis groups (p=0,001, p=0.01, respectively). Conclusion: We conclude that as allergic rhinitis increases the incidence of primary enuresis nocturna and worsens the quality of life, its treatment should not be neglected.
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