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Expression of COX-2 and MMP-9 in lacrimal gland epithelical tumors and significance to prognosis COX-2、MMP-9在泪腺上皮肿瘤中的表达及对预后的影响
Pub Date : 2017-05-10 DOI: 10.3760/CMA.J.ISSN.1006-4443.2017.05.008
Weiwei Liu, Ke Zhang
Objective To investigate the expression of cyclooxygenase(cox)-2 and matrix metalloproteinase (MMP)-9 in lacrimal gland epithelical tumors and the relations between pathology and clinic prognosis. Methods The samples were selected from lacrimal glands of 29 cases of ACC, 37cases of PA and 8 cases adjacent normaltissues. Expression of COX-2 and MMP-9 were detected by immunohistochemistry and then the clinical significance was analyzed. Results No expression of COX-2 or MMP-9 were detected in adjacent normal lacrimal glands. The level of COX-2 and MMP-9 expressed in ACC group were both higher than those in PA group (P <0.05). There was positive correlation between expression of COX-2 and MMP-9 (P <0.01).Significant differences in the risk of recurrence between positive and negative expression of COX-2 and MMP-9 were both noted (P <0.05). Conclusions COX-2 and MMP-9 may be closely related to the prognosis of patients. They can be considered as joint markers to be applied to predict the recurrent risk and to develop the treatment plan. Key words: Pleomorphicadenoma; adenoid cystic carcinoma; Cyclooxygenase-2; Matrix metalloproteninase-9; Prognosis
目的探讨环氧化酶(cox)-2和基质金属蛋白酶(MMP)-9在泪腺上皮肿瘤中的表达及其与临床预后的关系。方法选取29例ACC、37例PA和8例正常相邻组织的泪腺标本。免疫组化法检测COX-2、MMP-9的表达,分析其临床意义。结果癌旁正常泪腺未检测到COX-2、MMP-9的表达。ACC组COX-2、MMP-9表达水平均高于PA组(P <0.05)。COX-2与MMP-9的表达呈正相关(P <0.01)。COX-2、MMP-9阳性表达与阴性表达在复发风险上差异均有统计学意义(P <0.05)。结论COX-2和MMP-9可能与患者预后密切相关。它们可以作为预测复发风险和制定治疗计划的联合标志物。关键词:多形性腺瘤;腺样囊性癌;Cyclooxygenase-2;矩阵metalloproteninase-9;预后
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引用次数: 0
Expression and significance of α2 subunit of 20s proteasome in anterior capsule of lens in patients with age-related cataract 年龄相关性白内障患者晶状体前囊20s蛋白酶体α2亚基的表达及意义
Pub Date : 2017-05-10 DOI: 10.3760/CMA.J.ISSN.1006-4443.2017.05.023
Dandan Su, Jiusheng Zheng
Objective To identify the relationship between the degree of lens opacity and the hardness of nuclear and the protein expression level of 20s proteasome α2 subunit in age-related cataract patients. Methods Phacoemulsification or small incision cataract extraction was performed in 120 cases (60 cases of nuclear and 60 cases of cortical) and collected these anterior capsules. According to the degree of hardness and opacity of the lens nucleus, the nucleus was divided into group A: young nucleus, group B: old nuclear; cortical was divided into group A: mild opacity, group B: severe haze. Two types of cataract in group A, group B; and Western-blot was used to determine the 20s proteasome subunit alpha 2 expression levels in two groups of patients with ARC in the anterior lens capsule; experimental research work from July 2015 to March 2016. Results Compared with group A, the group B, 20s proteasome subunit α2 expression levels were significantly lower (nuclear (0.99±0.02) VS (0.58±0.08) P <0.01, cortical (1.26±0.15) VS (0.89±0.09), P <0.05, with the degree of lens opacity and nuclear hardness with the 20s proteasome α2 subunit content in age-related cataract patients was negatively correlated. Conclusions The protein expression levels of 20s protein α2 subunit in the anterior capsule of age-related cataract patients decrease with the degree of lens opacity and the hardness of the nucleus. Key words: Age-related cataract; 20s proteasome α2 subunit; Ubiquitin proteasome pathway; Anterior capsule
目的探讨老年性白内障患者晶状体混浊程度与晶状体核硬度及20s蛋白酶体α2亚基蛋白表达水平的关系。方法对120例(核性60例,皮质性60例)行超声乳化术或小切口白内障摘除术,收集前囊。根据晶状体核的硬度和不透明程度,将晶状体核分为A组:年轻核,B组:老核;皮层分为A组轻度浑浊,B组重度浑浊。A、B组白内障分两种;Western-blot检测两组前晶状体囊内20s蛋白酶体亚单位α 2的表达水平;2015年7月至2016年3月的实验研究工作。结果与A组、B组比较,20s蛋白酶体α2亚基表达水平显著降低(核(0.99±0.02)VS(0.58±0.08)P <0.01,皮质(1.26±0.15)VS(0.89±0.09)P <0.05,且晶状体不透明程度和核硬度与20s蛋白酶体α2亚基含量在年龄相关性白内障患者中呈负相关。结论年龄相关性白内障前囊20s蛋白α2亚基的表达水平随晶状体混浊程度和晶核硬度的增加而降低。关键词:老年性白内障;20s蛋白酶体α2亚基;泛素蛋白酶体途径;前囊
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引用次数: 0
Operative technique and clinical observation of anastomosis for disrupted canaliculus 小管断裂吻合术的手术技巧及临床观察
Pub Date : 2017-04-10 DOI: 10.3760/CMA.J.ISSN.1006-4443.2017.04.018
Hao Tang, Lan-Hua Shen
Objective TTo study the fracture finding methods and inferior lacrimal canaliculus anastomosis techniques, choosing the right duct support tubes to improve success rate of anastomosis of the disrupted canaliculus in emergency. Methods Directly under the microscope, looking for broken ends of the lateral inferior lacrimal canaliculus fracture, using extradural catheter new RS for support broken lacrimal duct ends by anastomosis of lacrimal canal. Results Of 128 tears tubular break (112 cases of the lower disrupted canaliculus, 16 upper disrupted canaliculus), 125 cases were anastomosis successfully, 3 cases could not find lacrimal sac while using open retrograde intubation with success. Conclusions It is a simple, easy, reliable and worth promoting method for anastomosis of broken lachrymal canaliculus. Key words: Ruptured inferior lacrimal; Anastomosis; Microscope; New RS lacrimal canal; Epidural catheter
目的探讨泪下小管断裂的发现方法和吻合技术,选择合适的导管支撑管,提高急诊泪下小管断裂的吻合成功率。方法直接在显微镜下寻找外侧下泪小管骨折断端,采用新RS硬膜外导管经泪管吻合术支撑断端。结果泪管断裂128例(下小管断裂112例,上小管断裂16例),吻合成功125例,开放逆行插管未找到泪囊3例,均成功。结论泪小管断裂吻合术简便、可靠,值得推广。关键词:下泪道破裂;吻合;显微镜;新RS泪道;硬膜外导管
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引用次数: 0
Analysis of the effect of shoelace continuous suture for conjunctival incision on preventing postsurgical shallow anterior chamber 结膜切口鞋带连续缝合预防术后浅前房的效果分析
Pub Date : 2017-04-10 DOI: 10.3760/CMA.J.ISSN.1006-4443.2017.04.009
Rong Lu, Jing Lin
Objective To analyze the effect of shoelace continuous suture for conjunctival incision on preventing postsurgical shallow anterior chamber. Methods Forty-one patients (82 eyes) diagnosed as primary glaucoma, and treated with trabeculectomy were included in this study during the period from March 2011 to March 2016. One eye, which was randomly chosen and applied shoelace continuous suture to attach the conjuctival fornix flap to the cornea, was included in observation group; the other eye, which under went same surgical procedure but applied conjuctival interrupted suture, was included in the control group. Intraocular pressure (IOP) and anterior chamber depth was measured and recorded after 3 days, 1 week and 1 month after surgery. Results Among the observation group, 3 days after surgery, IOP of 38 eyes was successfully controlled, IOP of 3 eyes was partially successfully controlled, with control rate as 100%; 1 week and 1 month after surgery, IOP of 37 eyes was successfully controlled, IOP of 3 eyes was partially successfully controlled, IOP of 1 eye was failed to control, with control rate as 97.56%. Among the control group, 3 days after surgery, IOP of 39 eyes was successfully controlled, IOP of 2 eyes was partially successfully controlled, with control rate as 100%; 1 week after surgery, IOP of 38 eyes was successfully controlled, IOP of 2 eyes was partially successfully controlled, IOP of 1 eye was failed to control, with control rate as 97.56%; 1 month after surgery, IOP of 37 eyes was successfully controlled, IOP of 2 eyes was partially successfully controlled, IOP of 2 eye was failed to control, with control rate as 95.12%. No significant difference was observed between two groups (P >0.05). Six eyes (6/41, 14.63%) had I degree shallow anterior chamber 3 days after surgery among the observation group, all recovered within 1 week without treatment, and remained stabilized 1 month after surgery; 12 eyes with shallow anterior chamber after surgery occurred in control group (12/41, 29.26%), significantly more than the observe group (χ2=18.76, P <0.01). Among them, 6 eyes had I degree shallow anterior chamber, 4 II degree shallow anterior chamber, and 1 III degree shallow anterior chamber. There were significantly more II and III degree shallow anterior chamber occurred in the control group (5/41, 12.19%) than observe group (0/41) (χ2=24.4, P <0.01). Eyes in the control group were recovered within 1-2 week after treatment, and stabilized after that. Conclusions Shoelace continu-ous suture for conjunctival incision can help preventing early stage postsurgical shallow anterior chamber. Key words: Shoelace continuous suture; Trabeculectomy; Anterior chamber
目的分析结膜切口鞋带连续缝合对预防术后浅前房的效果。方法选取2011年3月至2016年3月间行青光眼小梁切除术的原发性青光眼患者41例(82眼)。随机选取1只眼,用鞋带连续缝合将结缔组织瓣贴附于角膜上,作为观察组;另一只眼采用相同的手术方法,但采用结缔组织间断缝合,作为对照组。术后3天、1周、1个月测量眼压(IOP)和前房深度。结果观察组患者术后3 d眼压控制成功38眼,部分眼压控制成功3眼,控制率100%;术后1周和1个月,眼压控制成功37眼,部分控制成功3眼,眼压控制失败1眼,控制率为97.56%。对照组术后3 d成功控制眼压39眼,部分控制眼压2眼,控制率100%;术后1周,眼压控制成功38眼,部分控制成功2眼,未能控制1眼,控制率为97.56%;术后1个月,成功控制眼压37眼,部分控制眼压2眼,未能控制眼压2眼,控制率95.12%。两组间差异无统计学意义(P >0.05)。观察组6只眼(6/41,14.63%)术后3 d出现I度浅前房,均在1周内恢复,无需治疗,术后1个月病情稳定;对照组术后出现浅前房12眼(12/41,29.26%),明显多于观察组(χ2=18.76, P <0.01)。其中,I度浅前房6只眼,II度浅前房4只眼,III度浅前房1只眼。对照组II、III度浅前房发生率(5/41,12.19%)明显高于观察组(0/41)(χ2=24.4, P <0.01)。对照组患者治疗后1 ~ 2周眼恢复,术后稳定。结论结膜切口鞋带连续缝合可预防术后早期浅前房。关键词:鞋带连续缝合;小梁切除术;前房
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引用次数: 0
Effect of corneal curvature on the difference of intraocular lens in short eye axis 角膜曲率对短眼轴型人工晶状体差异的影响
Pub Date : 2017-04-10 DOI: 10.3760/CMA.J.ISSN.1006-4443.2017.04.005
Kangning Li, Zhiling Song, Chaojuan Ju
Objective To analyze the relationship between the average corneal curvature and the difference of intraocular lens (IOL)on both sides of the short eye axis. Methods Prospective study of corneal curvature on randomly collected 500 corneas of normal adult cataract patients. With the same corneal curvature, 177 cases of corneal curvature were obtained; the average of 177 cases of corneal curvature was obtained, the range of the average corneal curvature was 40.125-48.375D. In the range of average corneal curvature, according to the calculated critical axial length (21.97-22.02mm), the difference of IOL was obtained. The correlation on intraocular lens of difference and average corneal curvature were analyzed. Results There was a negative correlation between the difference of intraocular lens and the average corneal curvature in critical axial of short axis r=-0.968, P=0.000. Conclusions In normal adult cataract patients with normal corneal, the difference of intraocular lens number gradually becomes smaller with the increase of average corneal curvature. Key words: Corneal curvature; Short axis; Intraocular lens; Cataract
目的分析短眼轴两侧平均角膜曲率与人工晶状体(IOL)差异的关系。方法随机抽取500例正常成人白内障患者的角膜曲率进行前瞻性研究。在角膜曲率相同的情况下,获得角膜曲率177例;平均177例角膜曲率,平均角膜曲率范围为40.125 ~ 48.375 d。在平均角膜曲率范围内,根据计算出的临界眼轴长度(21.97 ~ 22.02mm),得出人工晶状体的差值。分析人工晶状体差值与平均角膜曲率的相关性。结果人工晶状体差值与短轴临界轴平均角膜曲率呈负相关(r=-0.968, P=0.000)。结论角膜正常的成人白内障患者,随着角膜平均曲率的增大,人工晶状体数的差异逐渐减小。关键词:角膜曲率;短轴;人工晶状体;白内障
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引用次数: 0
Observation of the surgical options and long-term effect of cataract combined with glaucoma 白内障合并青光眼的手术选择及远期疗效观察
Pub Date : 2017-04-10 DOI: 10.3760/CMA.J.ISSN.1006-4443.2017.04.014
Zhe Guo
Objective To explore the surgical approach of glaucoma combined with cataract and to observe its long-term clinical effect. Methods A total of 157 patients (183 eyes) with glaucoma combined with cataract were selected. Among them, 123 cases (131 eyes) of cataract were found by glaucoma admission, 34 cases (52 eyes) of glaucoma were found by cataract admission. There were 78 cases (87 eyes) of primary acute angle-closure glaucoma, 32 cases (47 eyes) of primary chronic angle-closure glau-coma, 3 cases (4 eyes) of primary open-angle glaucoma, cataract secondary glaucoma in 21 cases (21 eyes), residual glaucoma complicated with cataract in 23 cases (24 eyes). According to the cause of the disease, the course of disease, the degree of angle closure to choose different surgical methods, follow-up > 6 months to observe the treatment effect. Results Of 37 patients (41 eyes) underwent cataract surgery combined with glaucoma surgery (22.4%), 62 patients (73 eyes) underwent cataract surgery (39.9%) and 58 patients (69 eyes) underwent glaucoma surgery (37.7%). The intraocular pressure control was satisfactory in 136 cases (171 eyes, 93.4%) by not using or using 1-2 kinds of local reduction of intraocular pressure drugs, 11 cases (12 eyes, 6.6%) underwent secondary anti-glaucoma surgery. No serious complications occurred. Conclusions Various surgery approach for glaucoma with a cataract should be chosen depending on the different conditions. The success rate of operation should be improved to the maximum extent and the pain of the patients should be alleviated. Key words: Cataract secondary glaucoma; Clinical effect; Operation method; Residual glaucoma; Angle separation
目的探讨青光眼合并白内障的手术入路,并观察其远期临床疗效。方法选取青光眼合并白内障患者157例(183眼)。其中青光眼入院发现白内障123例(131眼),白内障入院发现青光眼34例(52眼)。原发性急性闭角型青光眼78例(87眼),原发性慢性闭角型青光眼32例(47眼),原发性开角型青光眼3例(4眼),白内障继发性青光眼21例(21眼),残余青光眼合并白内障23例(24眼)。根据发病原因、病程、闭角程度选择不同的手术方式,随访> 6个月观察治疗效果。结果37例(41眼)行白内障合并青光眼手术(22.4%),62例(73眼)行白内障手术(39.9%),58例(69眼)行青光眼手术(37.7%)。未使用或使用1-2种局部降眼压药物136例(171眼,93.4%)眼压控制满意,11例(12眼,6.6%)行二次抗青光眼手术。无严重并发症发生。结论青光眼合并白内障应根据不同情况选择不同的手术入路。最大限度地提高手术成功率,减轻患者的痛苦。关键词:白内障继发性青光眼;临床效果;操作方法;残余青光眼;角分离
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引用次数: 0
Analysis on tear film after phacoemul sification with different direction of clear cornea incisions with Keratograph 4 不同方向透明角膜切口超声成像后泪膜的分析
Pub Date : 2017-04-10 DOI: 10.3760/CMA.J.ISSN.1006-4443.2017.04.006
Guohua Wang
Objective To compare the changes in tear film after Microincision coaxial cataract surgery with different direction of clear cornea incisions with Keratograph 4. Methods A clinical case-control study. One hundred and forty-two patients (142 eyes) with age-related cataract were di-vided into two groups according to the surgical approach. Non-invasive tear break time (NIBUT), tear meniscus height, schirmer I test and subjective score for dryness were compared between two groups. Results One day, 7 days and 1 month postoperatively, both the mean NIBUT and tear meniscus height of the clear cornea incision above margin group reduced greatly than the clear corneaincision margin level group. The differences among two groups had significance statistically (Fgroup diff=7577.541, P <0.01; F group diff=9523.241, P <0.01). The values recovered to preoperative levels at 3 months postoperatively and there was no statistically significant difference among the two groups. At 1 day, 7 days, 1 month and 3 months postoperatively, the mean subjective scores for dryness of the a clear cornea incision margin level group were higher than the clear cornea incision above margin group; and a statistically significant difference among the two groups (F group diff=6781.533, P <0.01). All of the values recovered to preoperative levels at 3 months postoperatively. Conclusions A clear cornea incision above margin phacoemulsification bring less disturbance to ocular surface, brighter symptoms of dry eye and the patients feel more comfortable. Key words: Microincision coaxial cataract surgery; A clear cornea incision above margin; A clear cornea incision margin level; Tear film; Dryness
目的比较不同方向角膜透明切口的微切口同轴白内障术后泪膜的变化。方法采用临床病例-对照研究。将142只眼的老年性白内障患者按手术入路分为两组。比较两组无创撕裂破裂时间(NIBUT)、撕裂半月板高度、schirmer I测试及干爽主观评分。结果术后1天、7天和1个月,角膜缘以上透明切口组的平均NIBUT和撕裂半月板高度均明显低于角膜缘以上透明切口组。两组间差异有统计学意义(f组差异=7577.541,P <0.01;F组diff=9523.241, P <0.01)。术后3个月恢复至术前水平,两组比较差异无统计学意义。术后1天、7天、1个月、3个月,角膜切口边缘水平组干性主观评分平均值高于切口边缘以上组;两组间差异有统计学意义(F组差异=6781.533,P <0.01)。术后3个月,各项指标均恢复到术前水平。结论角膜缘以上切口清晰的超声乳化术对眼表的干扰小,干眼症状明显,患者感觉舒适。关键词:微切口白内障手术;边缘上有一个清晰的角膜切口;角膜切口边缘水平清晰;泪液膜;干燥
{"title":"Analysis on tear film after phacoemul sification with different direction of clear cornea incisions with Keratograph 4","authors":"Guohua Wang","doi":"10.3760/CMA.J.ISSN.1006-4443.2017.04.006","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1006-4443.2017.04.006","url":null,"abstract":"Objective \u0000To compare the changes in tear film after Microincision coaxial cataract surgery with different direction of clear cornea incisions with Keratograph 4. \u0000 \u0000 \u0000Methods \u0000A clinical case-control study. One hundred and forty-two patients (142 eyes) with age-related cataract were di-vided into two groups according to the surgical approach. Non-invasive tear break time (NIBUT), tear meniscus height, schirmer I test and subjective score for dryness were compared between two groups. \u0000 \u0000 \u0000Results \u0000One day, 7 days and 1 month postoperatively, both the mean NIBUT and tear meniscus height of the clear cornea incision above margin group reduced greatly than the clear corneaincision margin level group. The differences among two groups had significance statistically (Fgroup diff=7577.541, P <0.01; F group diff=9523.241, P <0.01). The values recovered to preoperative levels at 3 months postoperatively and there was no statistically significant difference among the two groups. At 1 day, 7 days, 1 month and 3 months postoperatively, the mean subjective scores for dryness of the a clear cornea incision margin level group were higher than the clear cornea incision above margin group; and a statistically significant difference among the two groups (F group diff=6781.533, P <0.01). All of the values recovered to preoperative levels at 3 months postoperatively. \u0000 \u0000 \u0000Conclusions \u0000A clear cornea incision above margin phacoemulsification bring less disturbance to ocular surface, brighter symptoms of dry eye and the patients feel more comfortable. \u0000 \u0000 \u0000Key words: \u0000Microincision coaxial cataract surgery; A clear cornea incision above margin; A clear cornea incision margin level; Tear film; Dryness","PeriodicalId":10236,"journal":{"name":"Chinese Journal of Practical Ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73140865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A study on the changes of female patients’ mental health before and after excimer laser surgery 准分子激光手术前后女性患者心理健康变化的研究
Pub Date : 2017-04-10 DOI: 10.3760/CMA.J.ISSN.1006-4443.2017.04.010
Jingjing Sun, C. Jiang
Objective To study the changes of female patients’ mental health before and after excimer laser surgery. Methods Forty three female patients with refractive error admitted in Peking University People’s Hospital and treated with excimer laser surgery from July 21, 2014 to September 30, 2014 were selected in the study. Results The force, anxiety, terror and psychoticism factor scores of the patients preoperatively were higher than the norm (P <0.05), while the positive factor numbers were also more than the norm (P <0.05). The interpersonal sensitivity and paranoid factor scores postoperation were lower than the norm (P <0.05). Compared with the preoperative, after sur-gery the somatization, force, interpersonal sensitivity, depression, anxiety, hostility, terror, paranoia and psychoticism scores were significantly decreased (P <0.05), and the positive factor numbers were also decreased significantly than preoperative (P <0.05). Conclusions There are obvious mental health problems preoperatively of female excimer laser surgery patients. The problems could be alleviated much after surgery. Key words: Excimer laser surgery; Female; SCL-90
目的探讨准分子激光手术前后女性患者心理健康状况的变化。方法选取2014年7月21日至2014年9月30日在北京大学人民医院接受准分子激光手术治疗的女性屈光不正患者43例。结果患者术前强迫、焦虑、恐惧、精神质因子得分均高于常模(P <0.05),阳性因子得分也高于常模(P <0.05)。术后人际敏感、偏执因子得分均低于正常值(P <0.05)。与术前比较,术后躯体化、用力、人际敏感、抑郁、焦虑、敌对、恐怖、偏执、精神病得分均显著降低(P <0.05),阳性因子数也显著降低(P <0.05)。结论女性准分子激光手术患者术前存在明显的心理健康问题。手术后这些问题可以得到很大的缓解。关键词:准分子激光手术;女性;sci - 90
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引用次数: 0
Pathogens and outcomes of fifty-one eyeball evisceration 51例眼球摘除的病原菌及预后分析
Pub Date : 2017-04-10 DOI: 10.3760/CMA.J.ISSN.1006-4443.2017.04.016
Jianmei Yuan
Objective To analyze pathogens and outcomes of fifty-one eyeball evisceration. Methods The data of pathogens and outcomes of 51 inpatients (51 eyes) undergone eyeball evisceration were collected and analyzed from January 2000 to May 2015 retrospectively. Results Fifty-one eyes consisted of 18 eyeball atrophy, 14 serious lacerated wound, 9 secondary glaucoma, 6 corneal ulcers with perforation, 4 entophthalmia. Conclusions Evisceration associated with stage Ⅰ implantation not only can decrease exposed implants and narrow conjunctival saccus, but also can reduce reoperation pains and economic pressures. Key words: Evisceration; Pathogen; Outcome
目的分析51例眼球摘除的致病菌及预后。方法回顾性分析2000年1月~ 2015年5月51例(51只眼)行眼球摘除手术的病原菌及转归资料。结果眼球萎缩18眼,严重撕裂伤14眼,继发性青光眼9眼,角膜溃疡伴穿孔6眼,眼内炎4眼。结论Ⅰ期植入术除可减少假体外露和结膜囊狭窄外,还可减少再次手术的痛苦和经济压力。关键词:内脏;病原体;结果
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引用次数: 0
25G pars plana vitrectomy combined with peeling of the inner limiting membrane and air tamponade in idiopathic macular hole 25G玻璃体切除联合内限定膜剥离及空气填塞
Pub Date : 2017-04-10 DOI: 10.3760/CMA.J.ISSN.1006-4443.2017.04.012
Xiayun Hu, Lina Zhang, Lifang Shen
Objective To evaluate the clinical effect of 25G pars plana vitrectomy with inner limiting membrane peeling and air tamponade for idiopathic macular hole (IMH). Methods Retrospectively examined 28 patients (28 eyes) with IMH in whom 25G vitrectomy, peeling of the inner limiting membrane underwent 0.25mg/ml brilliant blue G(BBG)-assisted, and application of sterile air tamponade were performed. The main observations were the surgical time, best corrected visual acuity (BCVA), intraocular pressure, the healing of macular hole and surgery complications. The follow-up period was 3-24 months (median 12.2±3.6 months). Results The operation lasted for 22-40minutes, meanly 28minutes, 28 cases were all successfully peeled of the inner limiting membrane, macular hole were closed in 28 eyes (100%), visual improvement was achieved in 21 eyes (75%), no eye was worse. The mean BCVA was 0.65±0.194 postoperatively, there was significant statistical differences compared with that before operation (t=13.768, P=0.000). The mean intraocular pressure at postoperative 1 week was (15.3±3.7) mmHg, closed to preoperative level. Eight eyes had punctate retinal hemorrhage when peeling of the inner limiting membrane, 4 eyes had nuclear cataract, 3 eyes had transient higher intraocular pressure, no other serious postoperative complications were observed during the follow-up time in all cases. Conclusions 25G vitrectomy with inner limiting membrane peeling and air tamponade is an effective and safe minimally invasive surgical technique, it can promote healing of macular hole, improve visual acuity, shorten operation time, decrease complication. Key words: 25G vitrectomy; Idiopathic macular hole; Inner limiting membrane peeling
目的评价25G玻璃体切割联合内限定膜剥离和空气填塞治疗特发性黄斑裂孔的临床效果。方法回顾性分析28例(28眼)IMH患者行25G玻璃体切除术,0.25mg/ml亮蓝G(BBG)辅助剥离内限定膜,应用无菌空气填塞。主要观察手术时间、最佳矫正视力(BCVA)、眼压、黄斑孔愈合情况及手术并发症。随访3 ~ 24个月(中位12.2±3.6个月)。结果手术时间22 ~ 40min,平均28min, 28例均成功剥去内限定膜,封闭黄斑孔28眼(100%),视力改善21眼(75%),无不良反应。术后平均BCVA为0.65±0.194,与术前比较差异有统计学意义(t=13.768, P=0.000)。术后1周平均眼压为(15.3±3.7)mmHg,与术前水平接近。内限制膜剥离时出现点状视网膜出血8眼,核性白内障4眼,一过性高眼压3眼,随访期间均未见其他严重术后并发症。结论25G玻璃体切除术联合内限定膜剥离和空气填塞是一种安全有效的微创手术技术,可促进黄斑裂孔愈合,提高视力,缩短手术时间,减少并发症。关键词:25G玻璃体切除术;特发性黄斑孔;内限定膜剥离
{"title":"25G pars plana vitrectomy combined with peeling of the inner limiting membrane and air tamponade in idiopathic macular hole","authors":"Xiayun Hu, Lina Zhang, Lifang Shen","doi":"10.3760/CMA.J.ISSN.1006-4443.2017.04.012","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1006-4443.2017.04.012","url":null,"abstract":"Objective \u0000To evaluate the clinical effect of 25G pars plana vitrectomy with inner limiting membrane peeling and air tamponade for idiopathic macular hole (IMH). \u0000 \u0000 \u0000Methods \u0000Retrospectively examined 28 patients (28 eyes) with IMH in whom 25G vitrectomy, peeling of the inner limiting membrane underwent 0.25mg/ml brilliant blue G(BBG)-assisted, and application of sterile air tamponade were performed. The main observations were the surgical time, best corrected visual acuity (BCVA), intraocular pressure, the healing of macular hole and surgery complications. The follow-up period was 3-24 months (median 12.2±3.6 months). \u0000 \u0000 \u0000Results \u0000The operation lasted for 22-40minutes, meanly 28minutes, 28 cases were all successfully peeled of the inner limiting membrane, macular hole were closed in 28 eyes (100%), visual improvement was achieved in 21 eyes (75%), no eye was worse. The mean BCVA was 0.65±0.194 postoperatively, there was significant statistical differences compared with that before operation (t=13.768, P=0.000). The mean intraocular pressure at postoperative 1 week was (15.3±3.7) mmHg, closed to preoperative level. Eight eyes had punctate retinal hemorrhage when peeling of the inner limiting membrane, 4 eyes had nuclear cataract, 3 eyes had transient higher intraocular pressure, no other serious postoperative complications were observed during the follow-up time in all cases. \u0000 \u0000 \u0000Conclusions \u000025G vitrectomy with inner limiting membrane peeling and air tamponade is an effective and safe minimally invasive surgical technique, it can promote healing of macular hole, improve visual acuity, shorten operation time, decrease complication. \u0000 \u0000 \u0000Key words: \u000025G vitrectomy; Idiopathic macular hole; Inner limiting membrane peeling","PeriodicalId":10236,"journal":{"name":"Chinese Journal of Practical Ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79069265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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