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The efficacy of intubation on adults lacrimal duct obstruction withnew generation silicon tube 新一代硅管插管治疗成人泪道梗阻的疗效观察
Pub Date : 2017-07-10 DOI: 10.3760/CMA.J.ISSN.1006-4443.2017.07.011
Shaobo Zhou, Juan Tan, Yuyan Guo
Objective To study the efficacy of intubation on adults lacrimal duct obstruction with new generation silicon tube. Methods A retrospective non-random and non-control case series. Thirty-two patients (37 eyes) with lacrimal duct obstruction who had undergone intubation with new generation silicon tube were retrospectively reviewed in Department of Ophthalmology, the First Affiliated Hospital of Guangzhou Medical University. The mean duration of symptoms of epiphora was 16.3±3.8 months. All the patients were followed up at least 3 months after the tube removal. Success rates were evaluated by both symptoms of epiphora and syringing. Results Among 37 eyes, 26 of 37 (70.3%) were cured completely, 4 eyes were relieved in epiphora, 24 of 27 eyes (88.9%) were cured or relievedin simple lacrimal duct obstruction, 6 of 10 eyes (60.0%) was cured or relieved in dacryocystitis(P <0.05). The success rate for patients whose duration of symptoms of epiphora within 2 yearswas much higher thanthat whose duration of symptoms over 2 years(P <0.05). Conclusions It seems that the intubation using new generation silicon tube has a high success ratefor lacrimal duct obstruction, especially for early simple lacrimal duct obstruction. Key words: Lacrimal duct obstruction; Dacryocystitis; Intubation
目的探讨新一代硅管插管治疗成人泪道梗阻的疗效。方法采用回顾性、非随机、非对照病例。回顾性分析了广州医科大学第一附属医院眼科行新一代硅管插管治疗泪道阻塞32例(37眼)的临床资料。症状的平均持续时间为16.3±3.8个月。所有患者在拔管后至少随访3个月。成功率评估两种症状的回眸和注射器。结果37眼全部治愈26眼(70.3%),泪显缓解4眼,单纯性泪管梗阻治愈或缓解24眼(88.9%),泪囊炎治愈或缓解6眼(60.0%)(P <0.05)。症状持续时间在2年以内的患者治疗成功率明显高于症状持续时间在2年以上的患者(P <0.05)。结论应用新一代硅管插管治疗泪道梗阻,成功率高,尤其对早期单纯性泪道梗阻疗效显著。关键词:泪道阻塞;泪囊炎;插管
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引用次数: 0
Observation effect of partial blepharosphincterectomy combined with Lower eyelid margin fixation to congenital lower eyelid entropion 眼睑部分切除联合下睑缘固定治疗先天性下睑内翻的疗效观察
Pub Date : 2017-07-10 DOI: 10.3760/CMA.J.ISSN.1006-4443.2017.07.020
Litao Gao, Rui Fan, Xue Li, F. Jin
Objective To evaluate the clinical effect of partial blepharosphincterectomy combined with Lower eyelid margin fixation to congenital lower eyelid entropion. Methods 41 patients (68 eyes) were analyzed retrospectively,from January 2013 to July 2015,aged 3-22 years old, Excision oculi muscle,6-0 absorbable line sutured 3-5 needles between tarsus and orbicularis muscle,suture Skin, removal stitches after 5-7 days,followed-up for 6 months to 2 years and 6 months,the recurrence、complications and satisfaction rates were summarized. Results During the follow-up,patients had no recurrence.The effective rate and satisfaction rate were 100%. Conclusions Congenital lower eyelid entropion with treatment of blepharosphincterectomy combined with the Lower eyelid margin fixation is effective. Key words: blepharosphincterectomy; fixation of inferior tarsal plate; congenital lower eyelid entropion
目的探讨眼睑部分切除联合下睑缘固定治疗先天性下睑内翻的临床效果。方法回顾性分析2013年1月至2015年7月41例(68眼)患者,年龄3-22岁,切除眼肌,6-0可吸收线缝合3-5针跗骨与轮匝肌之间,缝合皮肤,取线后5-7天,随访6个月至2年6个月,总结复发率、并发症及满意率。结果随访期间,患者无复发。有效率、满意率均为100%。结论先天性下睑内翻加眼睑切除联合下睑缘固定治疗是有效的。关键词:眼睑括约肌切除术;跗骨下板固定;先天性下眼睑内翻
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引用次数: 0
The study of optic nerve in human using high resolution MRI with multiplanar reconstruction 人类视神经的高分辨率MRI多平面重建研究
Pub Date : 2017-06-10 DOI: 10.3760/CMA.J.ISSN.1006-4443.2017.06.008
S. Liang, Yu Zhu, Zitao Yang
Objective To evaluate the images of optic nerve in normal human volunteers using three-dimensional high resolution MRI and multiplanar reconstruction. Methods A total of 30 healthy volunteers underwent magnetic resonance imaging (MRI) with the sequences of 3D-VIBE and 3D-DESS. The axis and oblique sagittal images were obtained with multiplanar reconstruction. The quality of the images was analyzed, and the length of the optic nerve was measured on axis and oblique sagittal images. Results The anatomy of the optic nerve could be clearly displayed on both axial and oblique sagittal images. The full length of optic nerve was 43.48±2.60 mm on axial image and 42.10±3.16 mm on oblique sagittal image. The measured value of axial image was higher than that of oblique sagittal image (t=2.98, P <0.01). Conclusions High resolution MRI with multiplanar reconstruction can visualize the fine structure of the optic nerve, and facilitate to measure the length of optic nerve, it can provide a reliable method for the study of the anatomy and diseases of optic nerve. Key words: Optic nerve; High resolution MRI; Multiplanar reconstruction
目的应用三维高分辨率MRI和多平面重建技术评价正常人视神经图像。方法对30名健康志愿者进行3D-VIBE和3D-DESS序列磁共振成像(MRI)。通过多平面重建获得轴矢状面和斜矢状面图像。对图像质量进行了分析,并在轴位和斜矢状位上测量了视神经的长度。结果在轴位和斜位矢状面均能清晰地显示视神经的解剖结构。视神经全长轴位为43.48±2.60 mm,斜矢状位为42.10±3.16 mm。轴位像的测量值高于斜矢状像(t=2.98, P <0.01)。结论采用多平面重建的高分辨率MRI能清晰地显示视神经的精细结构,方便测量视神经的长度,为视神经解剖和疾病的研究提供了可靠的方法。关键词:视神经;高分辨率MRI;多平面重建
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引用次数: 0
Intravitreal ranibizumab injection as an adjuvant combined 23-gauge vitrectomy and ahmed glaucoma valve implantation in the treatment of neovascular glaucoma 玻璃体内注射雷尼珠单抗辅助23号玻璃体切除联合ahmed青光眼瓣膜植入术治疗新生血管性青光眼
Pub Date : 2017-06-10 DOI: 10.3760/CMA.J.ISSN.1006-4443.2017.06.018
Jie Guo, Qiuming Li
Objective To observe the effects of intravitreal Ranibizumab injection (IVR) as an Adjuvant combined 23-gauge vitrectomy (23G-TSV) and Ahmed glaucoma valve (AGV) implantation for Neovascular Glaucoma (NVG). Methods Twenty-five patients (25 eyes) of NVG with vitreous hemorrhage (VH) underwent IVR combined with 23G-TSV and AGV implantation. Results The neovascularization of iris and anterior chamber angle in all patients completely or partly disappeared one week after IVR. At last visit, BCVA was improved compared with pre-operative BCVA; the IOP was significantly decreased after surgery; The surgical success rate was 88.0%. No serious complication occurred. Conclusions For stage Ⅲ NVG with VH, IVR as an adjuvant combined 23G-TSV and AGV implantation is safe and effective. Key words: Glaucoma; Neovascular; Implants; Ahmed; Vitrectomy; 23G; Ranibizumab
目的观察玻璃体内注射雷尼单抗(IVR)辅助23号玻璃体切除术(23G-TSV)联合Ahmed青光眼瓣膜(AGV)植入术治疗新生血管性青光眼(NVG)的疗效。方法25例(25眼)NVG合并玻璃体出血(VH)行IVR联合23G-TSV和AGV植入术。结果所有患者术后1周虹膜及前房角新生血管全部或部分消失。末次访视BCVA较术前有所改善;术后IOP明显降低;手术成功率为88.0%。无严重并发症发生。结论对于Ⅲ期NVG合并VH, IVR作为辅助23G-TSV联合AGV植入是安全有效的。关键词:青光眼;新生血管性;植入物;艾哈迈德;玻璃体切除术;23 g;之初
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引用次数: 0
Clinical study on risk factors of dry eye at north of Shan xi Province 陕北地区干眼症危险因素的临床研究
Pub Date : 2017-06-10 DOI: 10.3760/CMA.J.ISSN.1006-4443.2017.06.017
Li-li Gu, Wen-wei Zhong, Fan Gao, Yan-rong Wang
Objective To study the risk factors of dry eye disease (DED) in the north of Shannxi Province. Methods A case-control study data of 147 patients with DED and 162 patients free-DED were analyzed using logistic regression. Results Univariate analysis showed that the constitu-ent ratio of long-term outdoor, long-term video, local administration, history of eye disese and alcohol consumption were higer on patients with DED than that in controls (P <0.05) .Logistics regression analysis showed that the constituent ratio of long-term outdoor, long-term video, local administration, history of eye diseases were independent risk factors for DED. Conclusions Long-term outdoor, long-term video, local administration, history of eye disease are risk factors for DED in the north of Shannxi Province. Key words: dry eye; risk factor; north of Shan xi Province
目的探讨陕北地区干眼病(DED)的危险因素。方法采用logistic回归分析147例DED患者和162例非DED患者的病例对照研究资料。结果单因素分析显示,长期户外、长期视频、地方行政、眼病史和饮酒史在DED患者中的构成比高于对照组(P <0.05), logistic回归分析显示,长期户外、长期视频、地方行政、眼病史的构成比是DED的独立危险因素。结论长期户外、长期录像、地方管理、眼病史是陕北地区发生DED的危险因素。关键词:干眼症;风险因素;位于陕西省北部
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引用次数: 0
The contrast observation of the vitreous cavity injection of Combercept or Ranibizumab to treat wet age-related macular degeneration 玻璃体腔内注射康伯赛普与雷尼单抗治疗湿性老年性黄斑变性的对比观察
Pub Date : 2017-06-10 DOI: 10.3760/CMA.J.ISSN.1006-4443.2017.06.004
Zhan-sheng Shen
Objective To explore the clinical efficacy and safety, and to make the contrast obser-vation by using vitreous cavity injection of Combercept and Ranibizumab to treat wet age-related macular degeneration. Methods Clinical case control study. From June 2014 to June 2016, 103 patients (103 eyes) with wet AMD were enrolled in the second people's Hospital of Zhengzhou. ETDRS visual acuity chart, color fundus, fundus fluorescein angiography (FFA) and optical coherence tomography (OCT) were used to confirm the diagnosis. The patients were randomly divided into two groups according to random number table method, one group for Combercept treatment group (52 cases, 52 eyes) given the vitreous body cavity injection of 10 g/L Combercept of 0.05 ml (0.5 mg containing Combercept); one group for Ranibizumab treatment group (51 cases, 51 eyes) given vitreous body cavity injection of 0.05 ml (0.5 mg containing Ranibizumab). ETDRS visual acuity, macular center concave retinal thickness and choroid neovascularization (CNV) leakage of the two groups before and after treatment were follow-up for 10.65±2.27 months compared. Results Vitre-ous body injection therapy was 3 to 5 times for either Combercept or Ranibizumab, the average number of treatment was 3.65 times. ETDRS visual acuity compared with before treatment, the two groups were statistically significant (P <0.01) in 103 eyes after treatment at the end of the follow-up examination; The macular center concave retinal thickness was statistical significance between the two groups (P <0.01) compared with before treatment; Combercept treatment group: the macular area fluorescence leakage stopped in 28 eyes, reduce leakage 20 eyes, no obvious change in four eyes, Ranibizumab treatment group: the macular area fluorescence leakage stopped in 26 eyes, reduce leakage in 22 eyes, 3 eye had no obvious change. The two groups had no obvious statistics significant difference. Follow-up period had no injection and drug related ocular and systemic adverse reactions occur. Conclusions Vitreous cavity injection of Combercept or Ranibizumab for treatment of wet AMD has good curative effect. It can obviously increase the visual acuity, reduce the macular edema, and inhibit leakage of angiogenesis. There is no statistical difference between the two groups. Key words: Wet AMD; Combercept; Ranibizumab; Intravitreal injection; OCT; FFA
目的探讨康伯西普与雷尼单抗玻璃体腔注射治疗湿性老年性黄斑变性的临床疗效和安全性,并进行对比观察。方法临床病例对照研究。2014年6月至2016年6月,在郑州市第二人民医院纳入湿性黄斑变性患者103例(103眼)。采用ETDRS视力检查、彩色眼底、眼底荧光素血管造影(FFA)及光学相干断层扫描(OCT)证实诊断。按随机数字表法将患者随机分为两组,一组为康伯赛治疗组(52例,52眼)给予玻璃体腔内注射康伯赛10 g/L 0.05 ml(含康伯赛0.5 mg);1组为雷尼单抗治疗组(51例,51眼)给予玻璃体体腔注射0.05 ml(含雷尼单抗0.5 mg)。两组患者治疗前后ETDRS视力、黄斑中心凹视网膜厚度及脉络膜新生血管(CNV)渗漏情况随访10.65±2.27个月。结果康伯西普和雷尼单抗玻璃体注射治疗均为3 ~ 5次,平均治疗次数为3.65次。ETDRS视力与治疗前比较,两组治疗后随访检查103只眼,差异均有统计学意义(P <0.01);两组患者黄斑中心凹视网膜厚度与治疗前比较,差异均有统计学意义(P <0.01);康伯西普治疗组:黄斑区荧光渗漏停止28眼,减少渗漏20眼,无明显变化4眼;雷尼单抗治疗组:黄斑区荧光渗漏停止26眼,减少渗漏22眼,无明显变化3眼。两组比较差异无明显统计学意义。随访期间未发生与注射及药物相关的眼部及全身不良反应。结论玻璃体腔内注射康伯西普或雷尼单抗治疗湿性AMD疗效良好。能明显提高视力,减轻黄斑水肿,抑制血管生成渗漏。两组间无统计学差异。关键词:湿性AMD;Combercept;之初;Intravitreal注射;10月;FFA
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引用次数: 1
Study on the ocular biological effective ultraviolet irradiance and its risk evaluation in different altitude area 不同海拔地区眼部生物有效紫外线辐照度及其风险评价研究
Pub Date : 2017-06-10 DOI: 10.3760/CMA.J.ISSN.1006-4443.2017.06.026
Jiaming Yu, Yazhou Wang, Fang Wang, Q. Gao, Faming Li, Hui Hua, Rentong Chen, Yuyuan Guan
Objective To study on the ocular biological effective ultraviolet irradiance and its risk evaluation in two different altitude areas. Methods A self designed rotating manikin and dual-detector spectrometer were used to monitor the intensity of ocular exposure to UV irradiation under clear skies in Xichang and Shaoxing, of which the intensity of every time point, the average intensity of every hour, the accumulative total dose of every hour and the monitored accumulative total dose in whole day were calculated respectively. Results The diurnal variations of ocular biological effective ultraviolet irradiance and ratio of that to safety limit all exhibited bimodal distribution in Xichang and Shaoxing, the maximum ratio were 23.6 and 13.44, respectively. The accumulative total dose of every hour also exhibited bimodal distribution in two areas, the maximum of Xichang were 80.3 J/m2 and 69.87 J/m2, the ranges of solar elevation angle were 44.4°~55.4° and 54.3°~65.2°; the maximum of Shaoxing were 43.13 J/m2 and 46.75 J/m2, the ranges of solar elevation angle were38.9°~47.2° and 50.7°~60.2°. The monitored accumulative total dose in whole day in Xichang and Shaoxing were 564.7 J/m2 and 396.5 J/m2, respectively. Conclusions The diurnal variations of ocu-lar biological effective ultraviolet irradiance, ratios of that to safety limit and the accumulative total dose of every hour all exhibit bimodal distribution in two different altitude area. Under the same solar elevation angle, all data of Xichang show significant higher than those of Shaoxing. Key words: Altitude; Eye; Biological effective ultraviolet irradiance; Risk evaluation
目的研究不同海拔地区眼部生物有效紫外线辐照度及其风险评价。方法采用自行设计的旋转人体模型和双探测器光谱仪对西昌、绍兴两市晴空条件下眼部紫外线照射强度进行监测,分别计算各时间点照射强度、每小时照射平均强度、每小时照射累积总剂量和全天监测累积总剂量。结果西昌、绍兴地区眼部生物有效紫外线辐照度的日变化及其与安全限值的比值均呈双峰分布,最大比值分别为23.6和13.44。每h累积总剂量在两个地区也呈双峰分布,西昌最大剂量为80.3 J/m2和69.87 J/m2,太阳俯角范围为44.4°~55.4°和54.3°~65.2°;绍兴市的最大值为43.13 J/m2和46.75 J/m2,太阳仰角范围为38.9°~47.2°和50.7°~60.2°。西昌和绍兴监测的全天累计剂量分别为564.7 J/m2和396.5 J/m2。结论不同海拔地区的眼部生物有效紫外线辐照度、与安全限值的比值及每小时累积总剂量的日变化均呈双峰分布。在相同太阳仰角下,西昌的所有数据均显著高于绍兴。关键词:海拔;的眼睛;生物有效紫外辐照度;风险评估
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引用次数: 0
Association between ocular sensory dominance and refractive error asymmetry in myopes 近视眼感觉优势与屈光不对称的关系
Pub Date : 2017-06-10 DOI: 10.3760/CMA.J.ISSN.1006-4443.2017.06.014
Junping Huang, Binbin Su, Haoran Wu, Zheyi Chen, Siyu Jiang, Xuhong Zhang, Zuopao Zhuo, Bin Zhang, Jun Jiang
Objective To investigate the association between ocular sensory dominance and interocular refractive error difference (IRED) based on the discrimination of Gabor signal in myopes. Methods From December 2014 to October 2015, 361 myopia subjects at Eye Hospital of Wenzhou Medical University were recruited. Among them, based on the asymmetry between interocular spherical equivalent (SE), 177 subjects were non-anisometropic (IRED≤1D), 184 subjects were anisometropic (IRED>1D).Ocular sensory dominance was measured with computer-based psychophysics techniques. Ocular Sensory Index (OSI) was recorded when a subject just detected the Gabor signal during each trial. T-test was used to compare the 50 OSI values collected from each eye, and the t-val-ue was used as a subject’s ocular dominance index (ODI). Results No significant differences were found in SE, J0 and J45 between non-anisometropic and anisometropic subjects. IRED in non-anisometropic and anisometropic subjects were-0.58±0.33D and-2.52±1.29D respectively, which had significant differences between them (Wilcoxon rank sum test, Z=-20.13, P <0.01). ODI in anisometropic subjects was 4.04±3.74, which was significantly higher than ODI (3.35±2.87) in non-anisometropic subjects (Wilcoxon rank sum test, Z=-2.08, P=0.04). In anisometropic subjects, the IRED was correlated with ODI (Pearson correlation analysis, R=0.39, P <0.01). What’s more, the dominant eyes were more myopic in these anisometropic subjects (sign-test, P <0.05). Conclusions The anisometropic myopes have stronger ocular dominance in comparison to non-anisometropic myopes. ODI in myopes with clear dominance is associated with IRED, and the dominant eyes are more myopic. Key words: Sensory dominance; Anisometropia; Psychophysics; Myopia
目的通过对近视眼Gabor信号的辨别,探讨眼感觉优势与眼间屈光差(IRED)的关系。方法选取2014年12月~ 2015年10月温州医科大学眼科医院近视患者361例。其中,根据眼间球当量(SE)的不对称性,177例受试者为非各向异性(IRED≤1D), 184例受试者为各向异性(IRED>1D)。用基于计算机的心理物理技术测量眼感觉优势。在每次试验中,当受试者仅检测到Gabor信号时,记录眼球感觉指数(OSI)。采用t检验对每只眼睛采集的50个OSI值进行比较,并将t值作为受试者的眼优势指数(ODI)。结果非参差和参差受试者的SE、J0和J45无显著性差异。无参差和参差受试者的IRED分别为0.58±0.33D和2.52±1.29D,差异有统计学意义(Wilcoxon秩和检验,Z=-20.13, P <0.01)。各向异性受试者的ODI为4.04±3.74,显著高于非各向异性受试者的ODI(3.35±2.87)(Wilcoxon秩和检验,Z=-2.08, P=0.04)。在各向异性受试者中,IRED与ODI存在相关性(Pearson相关分析,R=0.39, P <0.01)。屈光参差者的主视眼近视程度更高(P <0.05)。结论屈光参差性近视比非屈光参差性近视具有更强的眼优势。显性近视的ODI与IRED相关,显性眼较近视。关键词:感觉优势;屈光参差症;心理物理学;近视
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引用次数: 0
Clinical analysis of femtosecond laser fragmentation of the nucleus with different sizes in cataract surgery 飞秒激光不同大小晶核碎裂在白内障手术中的临床分析
Pub Date : 2017-06-10 DOI: 10.3760/CMA.J.ISSN.1006-4443.2017.06.011
Wei Fan
Objective To compare the effect of different fragmentation softening grids in femtosecond laser-assisted cataract surgery on cumulative dissipated energy (CDE), effective phacoemulsification time (EPT), balanced salt solution volume during surgery and corneal endothelial cell loss. Methods A prospective cohort study of all patients (66 cases, 75 eyes) who accepted femtosecond laser-assisted cataract surgery in Xiamen ophthalmic center during June 2015 to November 2015 were randomly divided into 3 groups: group A: Frag and Chop (350 mm fragmentation grids and octants); group B: Cylinder (diameter:3.0mm); group C: Chop (sestants). Patients were evaluated preoperatively with the Lens Opacities Classification System III (LOCS III). The CDE, EPT, balanced salt solution volume, corneal endothelial cell loss and best corrected visual acuity (BCVA) at one month were compared. Results There was no statistically significant difference in LOCS III, preoperative corneal endothelial cell count in three groups (P >0.05). Comparing with the group B and C, the CDE, EPT and postoperative corneal endothelial cell loss were significantly lower in group A (CDE: group A: 4.7±2.8, group B: 6.4±3.1, group C: 6.6±3.0; EPT: group A: 23.9±12.0s, group B: 30.8±11.7s, group C: 32.1±12.6s; corneal endothelial cell loss: group A: 4.2±4.3%, group B: 6.7±4.4%, group C: 7.2±4.8%; P 0.05). Conclusions The use of the femtosecond laser-assisted system in cataract surgery with frag and chop led to a statistically significant lower CDE, EPT and postoperative corneal endothelial cell loss. Key words: Femtosecond laser; Cataract; Fragmentation; CDE; EPT
目的比较飞秒激光白内障手术中不同碎片软化网格对累积耗散能量(CDE)、有效超声乳化时间(EPT)、术中平衡盐溶液体积和角膜内皮细胞损失的影响。方法对2015年6月至2015年11月在厦门市眼科中心接受飞秒激光辅助白内障手术的66例75眼患者进行前瞻性队列研究,随机分为3组:A组:Frag和Chop (350 mm碎片网格和八边形);B组:圆柱体(直径3.0mm);C组:Chop (sestants)。术前采用晶状体混浊分级系统III (LOCS III)对患者进行评估,比较CDE、EPT、平衡盐溶液体积、角膜内皮细胞损失和1个月最佳矫正视力(BCVA)。结果三组患者LOCS III、术前角膜内皮细胞计数比较,差异均无统计学意义(P < 0.05)。与B、C组比较,A组CDE、EPT及术后角膜内皮细胞损失均显著降低(CDE: A组:4.7±2.8,B组:6.4±3.1,C组:6.6±3.0;EPT: A组:23.9±12.s, B组:30.8±11.7s, C组:32.1±12.s;角膜内皮细胞损失:A组:4.2±4.3%,B组:6.7±4.4%,C组:7.2±4.8%;P 0.05)。结论飞秒激光辅助系统在碎裂型白内障手术中应用可显著降低CDE、EPT及术后角膜内皮细胞损失。关键词:飞秒激光;白内障;碎片;CDE;EPT
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引用次数: 0
Amniotic membrane transplantation in diabetic corneal ulcer 羊膜移植治疗糖尿病性角膜溃疡
Pub Date : 2017-06-10 DOI: 10.3760/CMA.J.ISSN.1006-4443.2017.06.020
Zhi-qin Wu, Yanning Yang, Jing Yuan
Objective To evaluate the effects of amniotic membrane transplantation in refractory corneal ulcer accompanied with diabetes mellitus. Methods Sixteen patients with refractory diabetic corneal ulcer from March 2010 to February 2016 were included in this study. All patients were giv-en cornea scraping and microbial cultivation to exclude bacteria, fungal and amoebal infection. After strengthen controlling the blood sugar, all patients received amniotic membrane transplantation. According to the depth of the ulcer, the patient received a single layer or multi-layer amniotic membrane transplantation. Outcomes measured included corneal ulcer healing, best corrected visual acuity (BCVA) and complications. The follow-up period was 4-16 months. Results One patient received amniotic membrane transplantation twice. The corneal ulcer resolved in 16 patients in 2 weeks to 2 months postoperatively and formed macula or leukoma. At the last visit, BCVA was improved in all patients. There was no serious complication in the follow-up. Conclusions Amniotic membrane transplantation can effectively promote corneal healing. It is an effect treatment for refractory diabetic corneal ulcer. Key words: Diabetic keratopathy; Corneal ulcer; Amniotic membrane transplantation
目的探讨羊膜移植治疗难治性角膜溃疡合并糖尿病的疗效。方法选取2010年3月至2016年2月收治的16例难治性糖尿病性角膜溃疡患者。所有患者均行角膜刮痧和微生物培养,以排除细菌、真菌和阿米巴原虫感染。在加强血糖控制后,所有患者均行羊膜移植。根据溃疡的深度,对患者进行单层或多层羊膜移植。测量的结果包括角膜溃疡愈合、最佳矫正视力(BCVA)和并发症。随访4 ~ 16个月。结果1例患者接受两次羊膜移植。16例患者术后2周至2个月角膜溃疡消退,形成黄斑或白斑。最后一次访问时,所有患者的BCVA均有所改善。随访无严重并发症发生。结论羊膜移植可有效促进角膜愈合。是治疗难治性糖尿病性角膜溃疡的有效方法。关键词:糖尿病性角膜病变;角膜溃疡;羊膜移植
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引用次数: 0
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