Pub Date : 2017-05-10DOI: 10.3760/CMA.J.ISSN.1006-4443.2017.05.006
Chang-feng Guo
Objective To explore the influence of further consultation adherence on the increase of degree of myopia after myopia children wear glasses. Methods A total of 170 cases of myopia children were collected (spectacle lens power: 340) who had received treatment in our hospital and worn glasses during June 2013 to June 2015; and were divided into three groups according to regular further consultation period, among which there were 53 children in the group with three-month regular further consultation period, 60 children in the group with six-month regular further consultation period, 57 children in the group with one-year regular further consultation period; finally analyzed the changes of refractive status for patients after wearing glasses in 6 months and one year. Results Since there was no significant statistic difference (F=0.194, P=0.842) in ages when the patients in three groups were original diagnosed, and there was also no statistic difference (P >0.05) in diopter of spherical power, astigmatism degree, and spherical equivalent degree, the data collected had clinical comparability. In addition, there was no clear statistic difference in the increase of spherical equivalent degree for patients, with 3-month further consultation period and 6-month further consultation period, visiting the doctor in the sixth month. As for the three groups, the spherical equivalent degree increased respectively -0.79±0.37, -0.81±0.36 and -0.92±0.40 one year later. There were statistic differences in the comparison among three groups (F=4.066, P=0.018); for the comparison between 3-month group and 6-month group, there was no statistic differences (P >0.05); however there were statistic differences (P=0.009, P=0.022) between one-year group and 3-month group, one-year group and 6-month group. When the astigmatic degree was compared with the degree initially diagnosed one year ago, there was no statistic difference (P >0.05) for all three groups. Conclusions Regular further consultation and timely replacement lenses may slow progress myopia of school-age children in a certain degree. Key words: Myopia; Spherical equivalent; Further consultation adherence
{"title":"The influence of further consultation adherence on myopia progression after children wear glasses","authors":"Chang-feng Guo","doi":"10.3760/CMA.J.ISSN.1006-4443.2017.05.006","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1006-4443.2017.05.006","url":null,"abstract":"Objective \u0000To explore the influence of further consultation adherence on the increase of degree of myopia after myopia children wear glasses. \u0000 \u0000 \u0000Methods \u0000A total of 170 cases of myopia children were collected (spectacle lens power: 340) who had received treatment in our hospital and worn glasses during June 2013 to June 2015; and were divided into three groups according to regular further consultation period, among which there were 53 children in the group with three-month regular further consultation period, 60 children in the group with six-month regular further consultation period, 57 children in the group with one-year regular further consultation period; finally analyzed the changes of refractive status for patients after wearing glasses in 6 months and one year. \u0000 \u0000 \u0000Results \u0000Since there was no significant statistic difference (F=0.194, P=0.842) in ages when the patients in three groups were original diagnosed, and there was also no statistic difference (P >0.05) in diopter of spherical power, astigmatism degree, and spherical equivalent degree, the data collected had clinical comparability. In addition, there was no clear statistic difference in the increase of spherical equivalent degree for patients, with 3-month further consultation period and 6-month further consultation period, visiting the doctor in the sixth month. As for the three groups, the spherical equivalent degree increased respectively -0.79±0.37, -0.81±0.36 and -0.92±0.40 one year later. There were statistic differences in the comparison among three groups (F=4.066, P=0.018); for the comparison between 3-month group and 6-month group, there was no statistic differences (P >0.05); however there were statistic differences (P=0.009, P=0.022) between one-year group and 3-month group, one-year group and 6-month group. When the astigmatic degree was compared with the degree initially diagnosed one year ago, there was no statistic difference (P >0.05) for all three groups. \u0000 \u0000 \u0000Conclusions \u0000Regular further consultation and timely replacement lenses may slow progress myopia of school-age children in a certain degree. \u0000 \u0000 \u0000Key words: \u0000Myopia; Spherical equivalent; Further consultation adherence","PeriodicalId":10236,"journal":{"name":"Chinese Journal of Practical Ophthalmology","volume":"159 1","pages":"468-471"},"PeriodicalIF":0.0,"publicationDate":"2017-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88199300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-05-10DOI: 10.3760/CMA.J.ISSN.1006-4443.2017.05.016
J. Han
Objective To evaluate the therapeutic effectiveness of initial lacrimal passage irrigation and probing in neonatal dacryocystitis. Methods Fifty cases (58 eyes) with neonatal dacryocystitis which had no effect by routine dacryocyst massage with local antibiotics ophthalmic solutions were treated with passage irrigation and probing under local anesthesia to observe the therapeutic effectiveness. Results In this study, the success rate of initial lacrimal passage irrigation and probing for 50 cases (58 eyes) at 2-6 months of age was 100% (19/19), 39 eyes were in aged 6-18 months, in which 28 eyes cured with once probing, 7 eyes cured with twice probing, 4 eyes failed. Conclusions In neonatal dacryocystitis, aged above 2 months, lacrimal passage irrigation and probing should be performed as soon as possible which is also safe and feasible. Key words: Lacrimal passage irrigation and probing; Neonatal dacryocystitis; Therapeutic effect
{"title":"Clinical experience of initial lacrimal passage irrigation and probing in 50 cases of neonatal dacryocystitis","authors":"J. Han","doi":"10.3760/CMA.J.ISSN.1006-4443.2017.05.016","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1006-4443.2017.05.016","url":null,"abstract":"Objective \u0000To evaluate the therapeutic effectiveness of initial lacrimal passage irrigation and probing in neonatal dacryocystitis. \u0000 \u0000 \u0000Methods \u0000Fifty cases (58 eyes) with neonatal dacryocystitis which had no effect by routine dacryocyst massage with local antibiotics ophthalmic solutions were treated with passage irrigation and probing under local anesthesia to observe the therapeutic effectiveness. \u0000 \u0000 \u0000Results \u0000In this study, the success rate of initial lacrimal passage irrigation and probing for 50 cases (58 eyes) at 2-6 months of age was 100% (19/19), 39 eyes were in aged 6-18 months, in which 28 eyes cured with once probing, 7 eyes cured with twice probing, 4 eyes failed. \u0000 \u0000 \u0000Conclusions \u0000In neonatal dacryocystitis, aged above 2 months, lacrimal passage irrigation and probing should be performed as soon as possible which is also safe and feasible. \u0000 \u0000 \u0000Key words: \u0000Lacrimal passage irrigation and probing; Neonatal dacryocystitis; Therapeutic effect","PeriodicalId":10236,"journal":{"name":"Chinese Journal of Practical Ophthalmology","volume":"8 1","pages":"508-509"},"PeriodicalIF":0.0,"publicationDate":"2017-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80679085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-05-10DOI: 10.3760/CMA.J.ISSN.1006-4443.2017.05.015
R. Tian, Ming Li, Lulu Cheng, Ming-Yuan Yang, Wenjie Wang
Objective To observe the effect of laser photocoagulation on the hyphal structure of fungal corneal ulcer by using fluorescein staining. Methods A prospective research of 28 patients (28 eyes) diagnosed as Fungal Keratitis by using confocal laser corneal microscopy were followed up, who recruited from January 2016 to August 2016 in our hospital. Among them 19 males (19 eyes) and 9 females (9 eyes) with age ranging from 24 to 63, averages (44.00±0.00) years old. The average onset time was from 3 to 18 days, averaged (9.00±0.00) days. And hypopyon were observed in 9 cases (9 eyes). Besides topical anti-fungal Fluconazole Eye Drops and Natamycin Eye Drops, all patients also received fluorescein staining and laser photocoagulation under topical anesthesia for their cornea. Meanwhile, in vivo confocal laser-scanning microscopy were used to detect the positioning location, scope and structure changes after laser surgery of the fungal hyphae. Results Laser photocoagulation on the hyphal structure of fungal corneal ulcer detected by using fluorescein staining. Laser photocoagulation on the hyphal structure of fungal corneal ulcer detected by using fluorescein staining. Fungal corneal ulcer in the 28 patients (28 eyes) were all under control after the laser photocoagulation detected by using fluorescein staining. And hypopyon were decreased gradually in the 9 patients. After laser photocoagulation, the fungal mycelium structure in the ulcer was broken and melted detected by Confocal laser corneal microscopy. Noulcer recurrence was observed in 3 to 6 months after the follow-up. Conclusions Laser photocoagulation detected by using fluorescein staining leads to structural breakdown of the fungal hyphae of Fungal Keratitis. Confocal laser corneal microscopy is helpful to detect the positioning location, scope and structure changes after laser surgery of the fungal hyphae. Therefore, it is a safe, effective and precise way for the treatment of Fungal Keratitis. Key words: Fungus; Corneal ulcer; Confocal laser corneal microscopy; Laser photocoagulation
{"title":"The effect of laser photocoagulation on the hyphal structure of fungal corneal ulcer detected by using fluorescein staining","authors":"R. Tian, Ming Li, Lulu Cheng, Ming-Yuan Yang, Wenjie Wang","doi":"10.3760/CMA.J.ISSN.1006-4443.2017.05.015","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1006-4443.2017.05.015","url":null,"abstract":"Objective \u0000To observe the effect of laser photocoagulation on the hyphal structure of fungal corneal ulcer by using fluorescein staining. \u0000 \u0000 \u0000Methods \u0000A prospective research of 28 patients (28 eyes) diagnosed as Fungal Keratitis by using confocal laser corneal microscopy were followed up, who recruited from January 2016 to August 2016 in our hospital. Among them 19 males (19 eyes) and 9 females (9 eyes) with age ranging from 24 to 63, averages (44.00±0.00) years old. The average onset time was from 3 to 18 days, averaged (9.00±0.00) days. And hypopyon were observed in 9 cases (9 eyes). Besides topical anti-fungal Fluconazole Eye Drops and Natamycin Eye Drops, all patients also received fluorescein staining and laser photocoagulation under topical anesthesia for their cornea. Meanwhile, in vivo confocal laser-scanning microscopy were used to detect the positioning location, scope and structure changes after laser surgery of the fungal hyphae. \u0000 \u0000 \u0000Results \u0000Laser photocoagulation on the hyphal structure of fungal corneal ulcer detected by using fluorescein staining. Laser photocoagulation on the hyphal structure of fungal corneal ulcer detected by using fluorescein staining. Fungal corneal ulcer in the 28 patients (28 eyes) were all under control after the laser photocoagulation detected by using fluorescein staining. And hypopyon were decreased gradually in the 9 patients. After laser photocoagulation, the fungal mycelium structure in the ulcer was broken and melted detected by Confocal laser corneal microscopy. Noulcer recurrence was observed in 3 to 6 months after the follow-up. \u0000 \u0000 \u0000Conclusions \u0000Laser photocoagulation detected by using fluorescein staining leads to structural breakdown of the fungal hyphae of Fungal Keratitis. Confocal laser corneal microscopy is helpful to detect the positioning location, scope and structure changes after laser surgery of the fungal hyphae. Therefore, it is a safe, effective and precise way for the treatment of Fungal Keratitis. \u0000 \u0000 \u0000Key words: \u0000Fungus; Corneal ulcer; Confocal laser corneal microscopy; Laser photocoagulation","PeriodicalId":10236,"journal":{"name":"Chinese Journal of Practical Ophthalmology","volume":"80 1","pages":"505-507"},"PeriodicalIF":0.0,"publicationDate":"2017-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75086263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-05-10DOI: 10.3760/CMA.J.ISSN.1006-4443.2017.05.020
H. Kao, Y. Xie, B. Song
Objective To analyze the effect of autogenous ear cartilage in eyelid reconstruction. Methods Case analysis. From October 2006 to December 2013, totally 24 patients (24 eyes) of entire or greater than or equal to fifty percent blepharocoloboma after malignant palpebrae superior tumorectomy, admitted to Department of Ophthalmology in the Affiliated Hospital of Binzhou Medical College, were repaired with autogenous ear cartilage transplantation for the eyelid reconstruction. The autogenous ear cartilage was utilized for a substitude of tarsal plate. Eyelid tumors were removed completely, took the contralateral ear cartilage, made the length of 2 mm larger than the defect meibomian and equal width. The internal surface of ear cartilage was covered with remaining fornical conjunctiva and the external surface with orbicularis oculi and skin. Results All patients were followed up after operation for average 32.6 months. No reject reaction was found, catacleisis was fine and external appearance was satisfying. Conclusions The eyelid reconstruction with autogenous ear cartilage is available to keep eyelid reconstruction normal function and external appearance. Key words: Ear cartilage; Transplantation; Eyelid reconstruction; Blepharocoloboma
{"title":"Application of autogenous ear cartilage in eyelid reconstruction","authors":"H. Kao, Y. Xie, B. Song","doi":"10.3760/CMA.J.ISSN.1006-4443.2017.05.020","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1006-4443.2017.05.020","url":null,"abstract":"Objective \u0000To analyze the effect of autogenous ear cartilage in eyelid reconstruction. \u0000 \u0000 \u0000Methods \u0000Case analysis. From October 2006 to December 2013, totally 24 patients (24 eyes) of entire or greater than or equal to fifty percent blepharocoloboma after malignant palpebrae superior tumorectomy, admitted to Department of Ophthalmology in the Affiliated Hospital of Binzhou Medical College, were repaired with autogenous ear cartilage transplantation for the eyelid reconstruction. The autogenous ear cartilage was utilized for a substitude of tarsal plate. Eyelid tumors were removed completely, took the contralateral ear cartilage, made the length of 2 mm larger than the defect meibomian and equal width. The internal surface of ear cartilage was covered with remaining fornical conjunctiva and the external surface with orbicularis oculi and skin. \u0000 \u0000 \u0000Results \u0000All patients were followed up after operation for average 32.6 months. No reject reaction was found, catacleisis was fine and external appearance was satisfying. \u0000 \u0000 \u0000Conclusions \u0000The eyelid reconstruction with autogenous ear cartilage is available to keep eyelid reconstruction normal function and external appearance. \u0000 \u0000 \u0000Key words: \u0000Ear cartilage; Transplantation; Eyelid reconstruction; Blepharocoloboma","PeriodicalId":10236,"journal":{"name":"Chinese Journal of Practical Ophthalmology","volume":"34 1","pages":"521-523"},"PeriodicalIF":0.0,"publicationDate":"2017-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86898192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-05-10DOI: 10.3760/CMA.J.ISSN.1006-4443.2017.05.005
Chunyan C Cai, Wei-ming Xu, Hongbin Dai
Objective To investigate the outcome of anisometropic amblyopia therapy in children aged 7-17 years old and to identify factors which influence the outcome of treatment. Methods A retrospective study of 72 patients with anisometropic amblyopia aged 7-17 years old were included in this study. All the patients received refractive correction, occlusion of the sound eye and red scintillation. In addition, patients with eccentric fixation received Haidinger brush and afterimage therapy. Corrected visual acuity was considered improved as visual acuity was elevated by ≥2 lines. Results The best corrected visual acuity of the amblyopic eye was 0.28±0.18, 0.49±0.28, 0.60±0.32, 0.70±0.35 before treatment, after 3 months’, 6 months’ and 1year treatment. Among all the 72 patients, 55 patients’ visual acuity improved after 1-year treatment (76.4%). Only 8 patients’ visual acuity improved in 21 patients with eccentric fixation (38.1%), while 47 patients’ visual acuity improved in 51 patients with centric fixation (92.2%). 13, 33, 9 patients’ visual acuity improved in 26 severe, 37 moderate, 9 mild anisometropic amblyopia patients respectively. No one could get improved visual acuity without compliance. Conclusions Good results can be attained through combined therapy in older children with anisometropic amblyopia. The results are related to the initial severity of amblyopia, fixation of the amblyopic eye and compliance. Better outcome can be obtained in patients with mild to moderate amblyopia, centric fixation and good compliance. Key words: Anisometropic amblyopia; Older children; Therapy of amblyopia
{"title":"The outcome and related factors in anisometropic amblyopia in elder children and teenagers","authors":"Chunyan C Cai, Wei-ming Xu, Hongbin Dai","doi":"10.3760/CMA.J.ISSN.1006-4443.2017.05.005","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1006-4443.2017.05.005","url":null,"abstract":"Objective \u0000To investigate the outcome of anisometropic amblyopia therapy in children aged 7-17 years old and to identify factors which influence the outcome of treatment. \u0000 \u0000 \u0000Methods \u0000A retrospective study of 72 patients with anisometropic amblyopia aged 7-17 years old were included in this study. All the patients received refractive correction, occlusion of the sound eye and red scintillation. In addition, patients with eccentric fixation received Haidinger brush and afterimage therapy. Corrected visual acuity was considered improved as visual acuity was elevated by ≥2 lines. \u0000 \u0000 \u0000Results \u0000The best corrected visual acuity of the amblyopic eye was 0.28±0.18, 0.49±0.28, 0.60±0.32, 0.70±0.35 before treatment, after 3 months’, 6 months’ and 1year treatment. Among all the 72 patients, 55 patients’ visual acuity improved after 1-year treatment (76.4%). Only 8 patients’ visual acuity improved in 21 patients with eccentric fixation (38.1%), while 47 patients’ visual acuity improved in 51 patients with centric fixation (92.2%). 13, 33, 9 patients’ visual acuity improved in 26 severe, 37 moderate, 9 mild anisometropic amblyopia patients respectively. No one could get improved visual acuity without compliance. \u0000 \u0000 \u0000Conclusions \u0000Good results can be attained through combined therapy in older children with anisometropic amblyopia. The results are related to the initial severity of amblyopia, fixation of the amblyopic eye and compliance. Better outcome can be obtained in patients with mild to moderate amblyopia, centric fixation and good compliance. \u0000 \u0000 \u0000Key words: \u0000Anisometropic amblyopia; Older children; Therapy of amblyopia","PeriodicalId":10236,"journal":{"name":"Chinese Journal of Practical Ophthalmology","volume":"61 1","pages":"463-467"},"PeriodicalIF":0.0,"publicationDate":"2017-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83121034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-05-10DOI: 10.3760/CMA.J.ISSN.1006-4443.2017.05.014
Ningshu Liu, Na Liu, Wenting He, C. Zhang
Objective To modify the nasal mucosa flap during dacryocystorhinostomy for the treatment of traumatic dacryocystitis and observe its therapeutic effect. Methods Twenty six patients (27 eyes) of traumatic dacryocystitis were performed dacryocystorhinostomy. During the operation, the anterior and posterior nasal mucosa flaps of "" type was sutured to that of lacrimal sac mucosa flaps of "H" type. During 6 months, the state of mucosa flaps, tear washing, and tearing symptom was followed up. Patients with median canthoal tendon interruption received tendon repairing simultaneously. Patients with obvious orbital fracture received orbital reconstruction 3 to 4 months later. Results Among 26 patients with traumatic dacryocystitis, 20 male, 6 female, aged 5 to 63. During the operation of all patients, the distance between the nasal mucosa and the lacrimal sac became widen. All had nasal bone, lacrimal bone fracture at different degree; 18 patients with median canthoal tendon interruption, and 14 patients with obvious orbital fracture. Tear washing was smooth in all cases at 2 weeks follow up. At 6 months follow up, tear washing was smooth in 26 cases (one child still had tearing symptom), obstruction in 1 case. Conclusions The nasal mucosa flap of "" type is 1 time longer and narrower than that of "H" type, and offer a new way for patients with traumatic dacryocystitis, whom the distance between the nasal mucosa and the lacrimal sac became widen. Key words: Dacryocysto rhinostomy; Chronic dacrycystitis; Trauma
{"title":"The application of \"\" type nasal mucosa flaps during the surgical treatment of traumatic dacryocystitis","authors":"Ningshu Liu, Na Liu, Wenting He, C. Zhang","doi":"10.3760/CMA.J.ISSN.1006-4443.2017.05.014","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1006-4443.2017.05.014","url":null,"abstract":"Objective \u0000To modify the nasal mucosa flap during dacryocystorhinostomy for the treatment of traumatic dacryocystitis and observe its therapeutic effect. \u0000 \u0000 \u0000Methods \u0000Twenty six patients (27 eyes) of traumatic dacryocystitis were performed dacryocystorhinostomy. During the operation, the anterior and posterior nasal mucosa flaps of \"\" type was sutured to that of lacrimal sac mucosa flaps of \"H\" type. During 6 months, the state of mucosa flaps, tear washing, and tearing symptom was followed up. Patients with median canthoal tendon interruption received tendon repairing simultaneously. Patients with obvious orbital fracture received orbital reconstruction 3 to 4 months later. \u0000 \u0000 \u0000Results \u0000Among 26 patients with traumatic dacryocystitis, 20 male, 6 female, aged 5 to 63. During the operation of all patients, the distance between the nasal mucosa and the lacrimal sac became widen. All had nasal bone, lacrimal bone fracture at different degree; 18 patients with median canthoal tendon interruption, and 14 patients with obvious orbital fracture. Tear washing was smooth in all cases at 2 weeks follow up. At 6 months follow up, tear washing was smooth in 26 cases (one child still had tearing symptom), obstruction in 1 case. \u0000 \u0000 \u0000Conclusions \u0000The nasal mucosa flap of \"\" type is 1 time longer and narrower than that of \"H\" type, and offer a new way for patients with traumatic dacryocystitis, whom the distance between the nasal mucosa and the lacrimal sac became widen. \u0000 \u0000 \u0000Key words: \u0000Dacryocysto rhinostomy; Chronic dacrycystitis; Trauma","PeriodicalId":10236,"journal":{"name":"Chinese Journal of Practical Ophthalmology","volume":"2016 1","pages":"502-504"},"PeriodicalIF":0.0,"publicationDate":"2017-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73660412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective To investigate the effect of miR-204 expression on apoptosis of human lens epithelial cell line (LECs) SRA01/04 in vitro and the mechanism of targeting SIRT1. Methods Hydrogen peroxide (H2O2) was used to construct the cell apoptosis model of human lens epithelial cell line SRA01/04 in vitro. MiR-204 mimic and inhibitor were transiently transfected into SRA01/04 cells using Lipofectamine 2000 to regulate the expression level of miR-204. Flow cytometry was used to detect the cell apoptosis rate in each group SRA01/04 cells. By microRNA databases and recent study researches, we predicted that SIRT1 maybe a potential target gene of miR-204. Quantitative real-time PCR (qRT-PCR) were used to detect the expression level of miR-204 and SIRT1 gene. Results Quantitative real-time PCR results showed that the expression level of miR-204 in cell apoptosis model of SRA01/04 was significantly higher than the normal SRA01/04 cells. Overexpression of miR-204 in SRA01/04 promoted H2O2-induced cell apoptosis, and down-regulated the expression level of SIRT1 gene. While downexpression of miR-204 in SRA01/04 reduced H2O2-induced cell apoptosis, and up-regulated the expression level of SIRT1 gene. Each result was statistically significant (P <0.01). Conclusions The expression level of miR-204 in cell apoptosis model of SRA01/04 is significantly higher than the normal SRA01/04 cells. MiR-204 can regulate the apoptosis of the human lens epithelial cells by targeting SIRT1 gene. Thus, miR-204 may play an important role in the pathogenesis of caracts with lens epithelial cell apoptosis. Key words: miR-204; SIRT1; Cell apoptosis; Cataract
{"title":"Regulation mechanism of miR-204 targeted SIRT1 in human lens epithelial cell apoptosis","authors":"Xiao-Liang Xie, Jiangyue Zhao, Fangkun Zhao, Yu Qin","doi":"10.3760/CMA.J.ISSN.1006-4443.2017.05.022","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1006-4443.2017.05.022","url":null,"abstract":"Objective \u0000To investigate the effect of miR-204 expression on apoptosis of human lens epithelial cell line (LECs) SRA01/04 in vitro and the mechanism of targeting SIRT1. \u0000 \u0000 \u0000Methods \u0000Hydrogen peroxide (H2O2) was used to construct the cell apoptosis model of human lens epithelial cell line SRA01/04 in vitro. MiR-204 mimic and inhibitor were transiently transfected into SRA01/04 cells using Lipofectamine 2000 to regulate the expression level of miR-204. Flow cytometry was used to detect the cell apoptosis rate in each group SRA01/04 cells. By microRNA databases and recent study researches, we predicted that SIRT1 maybe a potential target gene of miR-204. Quantitative real-time PCR (qRT-PCR) were used to detect the expression level of miR-204 and SIRT1 gene. \u0000 \u0000 \u0000Results \u0000Quantitative real-time PCR results showed that the expression level of miR-204 in cell apoptosis model of SRA01/04 was significantly higher than the normal SRA01/04 cells. Overexpression of miR-204 in SRA01/04 promoted H2O2-induced cell apoptosis, and down-regulated the expression level of SIRT1 gene. While downexpression of miR-204 in SRA01/04 reduced H2O2-induced cell apoptosis, and up-regulated the expression level of SIRT1 gene. Each result was statistically significant (P <0.01). \u0000 \u0000 \u0000Conclusions \u0000The expression level of miR-204 in cell apoptosis model of SRA01/04 is significantly higher than the normal SRA01/04 cells. MiR-204 can regulate the apoptosis of the human lens epithelial cells by targeting SIRT1 gene. Thus, miR-204 may play an important role in the pathogenesis of caracts with lens epithelial cell apoptosis. \u0000 \u0000 \u0000Key words: \u0000miR-204; SIRT1; Cell apoptosis; Cataract","PeriodicalId":10236,"journal":{"name":"Chinese Journal of Practical Ophthalmology","volume":"27 1","pages":"527-532"},"PeriodicalIF":0.0,"publicationDate":"2017-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81405045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-05-10DOI: 10.3760/CMA.J.ISSN.1006-4443.2017.05.013
Xiaoling X. Sun, D. Pang, Jing Wang, Liyuan Sun
Objective To observe the effect of sulfur acid capsules of the treatment of age-related macular degeneration. Methods 120 patients with dry AMD treated in our hospital from May 2014 to Oct 2015 were divided into 2 groups randomly.60 patients treated with LA 0.2g each time, once a day orally, 60 patients treated with placebo vitamin C 0.05g each time, once a day orally.Before and after the intervention, the SOD value, BCVA,CS and CLVQOL values were measured before and after 3 months. The changes of patients were compared before and after intervention. Results Compared with pre intervention, serum SOD, middle-low frequency contrast sensitivity and CLVQOL score before and after the intervention were statistically significant (P 0.05) in treated group. CLVQOL scores were positively correlated with contrast sensitivity at low spatial frequency (3 cyc/degree) in LA-treated group. Conclusion LA capsules can improve the antioxidant capacity of dry AMD patients and improve the quality of life of patients. It is important to prevent the occurrence and development of dry AMD. Key words: AMD; α-lipoic acid capsules; SOD; CLVQOL; BCVA
{"title":"Clinical effects observation of α-lipoic acid treatment in patients with dry age-related macular degeneration","authors":"Xiaoling X. Sun, D. Pang, Jing Wang, Liyuan Sun","doi":"10.3760/CMA.J.ISSN.1006-4443.2017.05.013","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1006-4443.2017.05.013","url":null,"abstract":"Objective \u0000To observe the effect of sulfur acid capsules of the treatment of age-related macular degeneration. \u0000 \u0000 \u0000Methods \u0000120 patients with dry AMD treated in our hospital from May 2014 to Oct 2015 were divided into 2 groups randomly.60 patients treated with LA 0.2g each time, once a day orally, 60 patients treated with placebo vitamin C 0.05g each time, once a day orally.Before and after the intervention, the SOD value, BCVA,CS and CLVQOL values were measured before and after 3 months. The changes of patients were compared before and after intervention. \u0000 \u0000 \u0000Results \u0000Compared with pre intervention, serum SOD, middle-low frequency contrast sensitivity and CLVQOL score before and after the intervention were statistically significant (P 0.05) in treated group. CLVQOL scores were positively correlated with contrast sensitivity at low spatial frequency (3 cyc/degree) in LA-treated group. \u0000 \u0000 \u0000Conclusion \u0000LA capsules can improve the antioxidant capacity of dry AMD patients and improve the quality of life of patients. It is important to prevent the occurrence and development of dry AMD. \u0000 \u0000 \u0000Key words: \u0000AMD; α-lipoic acid capsules; SOD; CLVQOL; BCVA","PeriodicalId":10236,"journal":{"name":"Chinese Journal of Practical Ophthalmology","volume":"9 1","pages":"498-501"},"PeriodicalIF":0.0,"publicationDate":"2017-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81774550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-05-10DOI: 10.3760/CMA.J.ISSN.1006-4443.2017.05.018
Qin Xiao, Yu-ling Bai, Tian-zi Zhang, Zhan-jun Lu
Objective To observe the clinical effect of horizontal stretch of external canthus in the treatment of severe degenerative lower eyelid ectropion. Methods A retrospective clinical case study; 46 cases (68 eyes) of degenerative eyelid were randomly divided into treatment group and control group according to admission order, each for 23 cases (34 eyes). The treatment group underwent lateral canthal level pull operation, the control group underwent resection under the eyelid level, lower eyelid surgery according to the position of shortened lateral canthal ligament length. The location of the lower lacrimal gland, the location of the lower eyelid, the overflow of tears, foreign body sensation and conjunctival congestion after surgery were observed. Results The treatment group of 23 cases (34 eyes) of lower eyelid ectropion correction in 21 days, 2 cases (2 eyes) on the seventh day after surgery for lacrimal punctum ectropion underwent medial fusiform conjunctival resection, postoperative lower eyelid function improved, foreign body sensation, epiphora symptoms subsided. The control group of 23 cases (34 eyes) of lower eyelid ectropion in 21 days was corrected in 14 cases (21 eyes), 5 cases (7 eyes) of lower eyelid function improved, palpebral margin irregular, corneal irritation and affect the appearance of 4 cases (6 eyes) to open and close the lower eyelid could not close to the ocular surface. There was no significant difference between the two groups (P >0.05). There was no significant difference in the lower lacrimal spot and eyelid position between the two groups after surgery: P >0.05. There were significant differences in lacrimal overflow, foreign body sensation and conjunctival congestion P <0.05. Conclusions Adopting the horizontal stretch of external canthus in the treatment of degenerative ectropion would be aimed more pertinently at the primary problem of anatomy, with the advantage of less trauma and quick wound healing, without causing the eyelid defects and improving facial appearance. Key words: Degenerative ectropion; Horizontal stretch of external Canthus; Clinical observation
{"title":"Clinical observation on horizontal traction in the treatment of severe degenerative lower eyelid ectropion","authors":"Qin Xiao, Yu-ling Bai, Tian-zi Zhang, Zhan-jun Lu","doi":"10.3760/CMA.J.ISSN.1006-4443.2017.05.018","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1006-4443.2017.05.018","url":null,"abstract":"Objective \u0000To observe the clinical effect of horizontal stretch of external canthus in the treatment of severe degenerative lower eyelid ectropion. \u0000 \u0000 \u0000Methods \u0000A retrospective clinical case study; 46 cases (68 eyes) of degenerative eyelid were randomly divided into treatment group and control group according to admission order, each for 23 cases (34 eyes). The treatment group underwent lateral canthal level pull operation, the control group underwent resection under the eyelid level, lower eyelid surgery according to the position of shortened lateral canthal ligament length. The location of the lower lacrimal gland, the location of the lower eyelid, the overflow of tears, foreign body sensation and conjunctival congestion after surgery were observed. \u0000 \u0000 \u0000Results \u0000The treatment group of 23 cases (34 eyes) of lower eyelid ectropion correction in 21 days, 2 cases (2 eyes) on the seventh day after surgery for lacrimal punctum ectropion underwent medial fusiform conjunctival resection, postoperative lower eyelid function improved, foreign body sensation, epiphora symptoms subsided. The control group of 23 cases (34 eyes) of lower eyelid ectropion in 21 days was corrected in 14 cases (21 eyes), 5 cases (7 eyes) of lower eyelid function improved, palpebral margin irregular, corneal irritation and affect the appearance of 4 cases (6 eyes) to open and close the lower eyelid could not close to the ocular surface. There was no significant difference between the two groups (P >0.05). There was no significant difference in the lower lacrimal spot and eyelid position between the two groups after surgery: P >0.05. There were significant differences in lacrimal overflow, foreign body sensation and conjunctival congestion P <0.05. \u0000 \u0000 \u0000Conclusions \u0000Adopting the horizontal stretch of external canthus in the treatment of degenerative ectropion would be aimed more pertinently at the primary problem of anatomy, with the advantage of less trauma and quick wound healing, without causing the eyelid defects and improving facial appearance. \u0000 \u0000 \u0000Key words: \u0000Degenerative ectropion; Horizontal stretch of external Canthus; Clinical observation","PeriodicalId":10236,"journal":{"name":"Chinese Journal of Practical Ophthalmology","volume":" 41","pages":"514-517"},"PeriodicalIF":0.0,"publicationDate":"2017-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72508517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-05-10DOI: 10.3760/CMA.J.ISSN.1006-4443.2017.05.009
Ning Li, Qi-Wen Zhong
Objective To investigate the effect of the refractive status and central cornea thickness (CCT) on Goldmann applanation tonometry (GAT). Methods A total of 119 cases of normal subjects (195 eyes) and 74 cases of myopia (148 eyes) were included in this study. The CCT was measured by Pentacam and intraocular pressure (IOP) by using GAT. SPSS17.0 was used to process the data. Results The average CCT of the normal group was (525.07±38.58)μm. The mean IOP was (12.96±2.64)mmHg. The difference on both IOP and the mean CCT between low myopia group and normal group had statistically significant. The difference in IOP between high myopia group and normal group had statistically significant. The IOP of myopia group was negatively correlated with diopter (r=-0.396, P <0.001). IOP increased 1mmHg with per -3.86D increase. IOP of normal and myopic groups correction formulas were 1mmHg/45.55μm, 1mmHg/34.46μm, respectively. Conclusions CCT and refractive state can influence IOP. Key words: Refractive status; Central corneal thickness; Goldmann applanation tonometry; Pentacam; IOP correction
目的探讨屈光状态和角膜中央厚度(CCT)对Goldmann眼压测量(GAT)的影响。方法选取119例正常人(195眼)和74例近视眼(148眼)作为研究对象。用Pentacam测定CCT，用GAT测定眼压。采用SPSS17.0软件对数据进行处理。结果正常组CCT平均值为(525.07±38.58)μm。平均眼压为(12.96±2.64)mmHg。低近视组与正常组的IOP及平均CCT差异有统计学意义。高度近视组与正常组的IOP差异有统计学意义。近视组的IOP与屈光度呈负相关(r=-0.396, P <0.001)。每增加-3.86D，眼压升高1mmHg。正常组和近视组的IOP矫正公式分别为1mmHg/45.55μm、1mmHg/34.46μm。结论CCT和屈光状态对IOP有影响。关键词:折射状态;角膜中央厚度;戈德曼压平测压法;Pentacam;IOP校正
{"title":"The effects of refractive status and central corneal thickness on applanation tonometry measurements","authors":"Ning Li, Qi-Wen Zhong","doi":"10.3760/CMA.J.ISSN.1006-4443.2017.05.009","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1006-4443.2017.05.009","url":null,"abstract":"Objective \u0000To investigate the effect of the refractive status and central cornea thickness (CCT) on Goldmann applanation tonometry (GAT). \u0000 \u0000 \u0000Methods \u0000A total of 119 cases of normal subjects (195 eyes) and 74 cases of myopia (148 eyes) were included in this study. The CCT was measured by Pentacam and intraocular pressure (IOP) by using GAT. SPSS17.0 was used to process the data. \u0000 \u0000 \u0000Results \u0000The average CCT of the normal group was (525.07±38.58)μm. The mean IOP was (12.96±2.64)mmHg. The difference on both IOP and the mean CCT between low myopia group and normal group had statistically significant. The difference in IOP between high myopia group and normal group had statistically significant. The IOP of myopia group was negatively correlated with diopter (r=-0.396, P <0.001). IOP increased 1mmHg with per -3.86D increase. IOP of normal and myopic groups correction formulas were 1mmHg/45.55μm, 1mmHg/34.46μm, respectively. \u0000 \u0000 \u0000Conclusions \u0000CCT and refractive state can influence IOP. \u0000 \u0000 \u0000Key words: \u0000Refractive status; Central corneal thickness; Goldmann applanation tonometry; Pentacam; IOP correction","PeriodicalId":10236,"journal":{"name":"Chinese Journal of Practical Ophthalmology","volume":"1 1","pages":"480-485"},"PeriodicalIF":0.0,"publicationDate":"2017-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76169424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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