Pub Date : 2019-09-01DOI: 10.3760/CMA.J.ISSN.1008-6315.2019.05.002
Chenglong Miao, Yanwei Wang, Lu Xu, Suyun Liu
Objective To observe whether catheter ablation for ventricular premature complexes (PVC) has an effect on ventricular diastolic function in elderly patients. Methods Elderly patients older than 65 years of age who underwent catheter ablation from March 2012 to May 2015 for idiopathic ventricular premature complexes were enrolled.Preoperative echocardiography was performed using E/e′ for left ventricular diastolic function and venous brain natriuretic peptide (BNP) levels were measured.All patients underwent catheter ablation under the guidance of a three-dimensional mapping system.Cardiac ultrasound and BNP levels were repeated 6 months after ablation, and 24-hour electrocardiogram was performed to confirm ventricular premature complexes. Results There were a total of 89 patients with idiopathic ventricular premature complexes (PVC) who underwent catheter ablation.81 cases were successed at 6 months, with a success rate of 91.0%.At 6 months after ablation, the E/e′ values were significantly lower ((15.3±5.2) vs (10.2±3.2), (P 0.05). Conclusion The number of premature ventricular beats is associated with left ventricular diastolic function, and ventricular premature catheter ablation can improve left ventricular diastolic function in elderly PVC patients. Key words: Ventricular premature complexes; Catheter ablation; Diastolic function; Brain natriuretic peptide; The aged
目的观察导管消融术治疗室性早衰(PVC)对老年患者心室舒张功能的影响。方法选取2012年3月至2015年5月因特发性室性早衰并发症行导管消融治疗的年龄大于65岁的老年患者。术前行超声心动图E/ E '检查左室舒张功能，测定静脉脑钠肽(BNP)水平。所有患者均在三维绘图系统的指导下行导管消融。消融后6个月复查心脏超声和BNP水平，24小时心电图确认心室过早复合物。结果89例特发性室性早衰(PVC)患者行导管消融治疗。6个月成功81例，成功率91.0%。消融后6个月，E/ E值明显降低(15.3±5.2)vs(10.2±3.2)，P < 0.05。结论室性早搏次数与左室舒张功能有关，室性早搏导管消融可改善老年室性早搏患者左室舒张功能。关键词:心室过早复合物;导管消融;舒张功能;脑利钠肽;老年人
{"title":"Effect of ventricular premature catheter ablation on diastolic function in elderly patients","authors":"Chenglong Miao, Yanwei Wang, Lu Xu, Suyun Liu","doi":"10.3760/CMA.J.ISSN.1008-6315.2019.05.002","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6315.2019.05.002","url":null,"abstract":"Objective \u0000To observe whether catheter ablation for ventricular premature complexes (PVC) has an effect on ventricular diastolic function in elderly patients. \u0000 \u0000 \u0000Methods \u0000Elderly patients older than 65 years of age who underwent catheter ablation from March 2012 to May 2015 for idiopathic ventricular premature complexes were enrolled.Preoperative echocardiography was performed using E/e′ for left ventricular diastolic function and venous brain natriuretic peptide (BNP) levels were measured.All patients underwent catheter ablation under the guidance of a three-dimensional mapping system.Cardiac ultrasound and BNP levels were repeated 6 months after ablation, and 24-hour electrocardiogram was performed to confirm ventricular premature complexes. \u0000 \u0000 \u0000Results \u0000There were a total of 89 patients with idiopathic ventricular premature complexes (PVC) who underwent catheter ablation.81 cases were successed at 6 months, with a success rate of 91.0%.At 6 months after ablation, the E/e′ values were significantly lower ((15.3±5.2) vs (10.2±3.2), (P 0.05). \u0000 \u0000 \u0000Conclusion \u0000The number of premature ventricular beats is associated with left ventricular diastolic function, and ventricular premature catheter ablation can improve left ventricular diastolic function in elderly PVC patients. \u0000 \u0000 \u0000Key words: \u0000Ventricular premature complexes; Catheter ablation; Diastolic function; Brain natriuretic peptide; The aged","PeriodicalId":10365,"journal":{"name":"Clinical Medicine of China","volume":"35 1","pages":"391-395"},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69920630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective To investigate the effects of poly adenosine diphosphate ribose polymerase (PARP) inhibitor AG014699 on the proliferation of triple negative breast cancer (TNBC) cell line MDA-MB-231. Methods Cell proliferation and cytotoxicity test kit (CCK-8) was used to detect the proliferation of MDA-MB-231 cells in different concentrations of AG014699 (0.1, 1.0, 10.0, 20.0 and 40.0 mmol/L), DTX (10-9, 10-8, 10-7, 10-6 and 10-5 mol/L) and CBP (10-6, 10-5, 10-4 and 10-3 mol/L). Flow cytometry was used to detect cell apoptosis and cell cycle distribution. Results The effects of AG01469 at different concentrations (0.1, 1.0, 10.0, 20.0 and 40.0 μmol/L) on proliferation activity of MDA-MB-231 cells were(94.83±3.93)%, (79.42±5.52)%, (63.75±4.34)%, (38.97±8.42)%, (29.70±3.35)%, with statistically significant differences (F=75.54, P 0.05 at 10-9 concentration and P 0.05 at 10-6 concentration, P 1.15 when AG014699 was combined with 10-3 mmol/L CBP, which showed synergistic effect.When combined with other effective concentrations of DTX or CBP, the q value was between 0.85 and 1.15, showing additive effect. Conclusion PARP inhibitor AG014699 assisted DTX or CBP can inhibit the proliferation of TNBC cell line MDA-MB-231.By means of simple addition or systematic effect, it can inhibit the triple negative breast cancer. Key words: Triple negative breast cancer; Poly adenosine diphosphate ribose polymerase; Docetaxel; Carboplatin
{"title":"Analysis of the efficacy of poly ADP-ribose polymerases inhibitor combined with chemotherapeutics in the treatment of triple negative breast cancer","authors":"Jinji Zhang, Zhonghui Li, Changzai Li, Lijun Meng, Xiu-li Zhang","doi":"10.3760/CMA.J.ISSN.1008-6315.2019.05.009","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6315.2019.05.009","url":null,"abstract":"Objective \u0000To investigate the effects of poly adenosine diphosphate ribose polymerase (PARP) inhibitor AG014699 on the proliferation of triple negative breast cancer (TNBC) cell line MDA-MB-231. \u0000 \u0000 \u0000Methods \u0000Cell proliferation and cytotoxicity test kit (CCK-8) was used to detect the proliferation of MDA-MB-231 cells in different concentrations of AG014699 (0.1, 1.0, 10.0, 20.0 and 40.0 mmol/L), DTX (10-9, 10-8, 10-7, 10-6 and 10-5 mol/L) and CBP (10-6, 10-5, 10-4 and 10-3 mol/L). Flow cytometry was used to detect cell apoptosis and cell cycle distribution. \u0000 \u0000 \u0000Results \u0000The effects of AG01469 at different concentrations (0.1, 1.0, 10.0, 20.0 and 40.0 μmol/L) on proliferation activity of MDA-MB-231 cells were(94.83±3.93)%, (79.42±5.52)%, (63.75±4.34)%, (38.97±8.42)%, (29.70±3.35)%, with statistically significant differences (F=75.54, P 0.05 at 10-9 concentration and P 0.05 at 10-6 concentration, P 1.15 when AG014699 was combined with 10-3 mmol/L CBP, which showed synergistic effect.When combined with other effective concentrations of DTX or CBP, the q value was between 0.85 and 1.15, showing additive effect. \u0000 \u0000 \u0000Conclusion \u0000PARP inhibitor AG014699 assisted DTX or CBP can inhibit the proliferation of TNBC cell line MDA-MB-231.By means of simple addition or systematic effect, it can inhibit the triple negative breast cancer. \u0000 \u0000 \u0000Key words: \u0000Triple negative breast cancer; Poly adenosine diphosphate ribose polymerase; Docetaxel; Carboplatin","PeriodicalId":10365,"journal":{"name":"Clinical Medicine of China","volume":"35 1","pages":"421-425"},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45073209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-01DOI: 10.3760/CMA.J.ISSN.1008-6315.2019.05.011
Ke Liu, Qiang Li, Yanfang Hu, Lihua Xu, Shuangping Li, P. Hu
Objective To observe the characteristics of apathy in early Parkinson′s disease patients, analyze its relationship with other non-motor symptoms, and explore its impact on the quality of life. Methods Clinical data of 75 patients with Parkinson′s disease admitted to xingtai people′s hospital from August 2014 to August 2017 were selected.Unified Parkinson′s disease rating scale- III(UPDRS-III ), Modified apathy rating scale(MAES ), Montgomy-asberg Depression rating scale(MADRS ) and Simple mental state test(MMSE) were used to evaluate patients′ motor symptoms, indifference, depression and cognitive function.The relationship between apathy and other non-motor symptoms was analyzed by Parkinson′s disease non-motor symptom evaluation scale.Parkinson′s disease questionnaire-39(PDQ-39) was used to evaluate the quality of life.The patients were divided into the affective indifference group and the non-affective indifference group according to whether the patients were accompanied by affective indifference. Results 21.3%(16/75) of the patients were diagnosed with apathy.Emotional indifference group UPDRS score -Ⅲ (23.98±9.46), not apathy group(14.74±6.27). There was significant difference between the two groups (P<0.001). MMSE score of the indifferent group was (21.26±3.21), and that of the non-indifferent group was (26.57±3.42). There was significant difference between the two groups (P=0.038). PDQ-39 score of the emotionally indifferent group was (65.20±25.78), which was significantly higher than that of the non-emotionally indifferent group (34.86±25.42). There was significant difference between the two groups (P<0.001). In the comparison of Parkinson′s disease non-motor symptom evaluation scale, the fatigue symptom score of the emotionally indifferent group was (6.1±0.2) significantly higher than that of the non-indifferent group (2.3±0.7), and the difference was statistically significant (P=0.006). The score of lack of interest was (4.8±1.5) in the indifferent group and (1.3±0.8) in the non-indifferent group.The difference between the two groups was statistically significant (P=0.017). Conclusion Apathy has a high incidence in early Parkinson′s disease patients, often combined with fatigue and lack of interest symptoms.It has a serious impact on the quality of daily life in the future. Key words: Parkinson′s disease; Apathy; Unified Parkinson′s disease rating scale- III; Modified apathy evaluation scale; Montgomery-asberg depression rating scale; Mini-mental state examination; Non-motor symptom; Quality of life
{"title":"Clinical characteristics of early Parkinson′s disease patients with emotional apathy and its relationship with other non-motor symptoms","authors":"Ke Liu, Qiang Li, Yanfang Hu, Lihua Xu, Shuangping Li, P. Hu","doi":"10.3760/CMA.J.ISSN.1008-6315.2019.05.011","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6315.2019.05.011","url":null,"abstract":"Objective \u0000To observe the characteristics of apathy in early Parkinson′s disease patients, analyze its relationship with other non-motor symptoms, and explore its impact on the quality of life. \u0000 \u0000 \u0000Methods \u0000Clinical data of 75 patients with Parkinson′s disease admitted to xingtai people′s hospital from August 2014 to August 2017 were selected.Unified Parkinson′s disease rating scale- III(UPDRS-III ), Modified apathy rating scale(MAES ), Montgomy-asberg Depression rating scale(MADRS ) and Simple mental state test(MMSE) were used to evaluate patients′ motor symptoms, indifference, depression and cognitive function.The relationship between apathy and other non-motor symptoms was analyzed by Parkinson′s disease non-motor symptom evaluation scale.Parkinson′s disease questionnaire-39(PDQ-39) was used to evaluate the quality of life.The patients were divided into the affective indifference group and the non-affective indifference group according to whether the patients were accompanied by affective indifference. \u0000 \u0000 \u0000Results \u000021.3%(16/75) of the patients were diagnosed with apathy.Emotional indifference group UPDRS score -Ⅲ (23.98±9.46), not apathy group(14.74±6.27). There was significant difference between the two groups (P<0.001). MMSE score of the indifferent group was (21.26±3.21), and that of the non-indifferent group was (26.57±3.42). There was significant difference between the two groups (P=0.038). PDQ-39 score of the emotionally indifferent group was (65.20±25.78), which was significantly higher than that of the non-emotionally indifferent group (34.86±25.42). There was significant difference between the two groups (P<0.001). In the comparison of Parkinson′s disease non-motor symptom evaluation scale, the fatigue symptom score of the emotionally indifferent group was (6.1±0.2) significantly higher than that of the non-indifferent group (2.3±0.7), and the difference was statistically significant (P=0.006). The score of lack of interest was (4.8±1.5) in the indifferent group and (1.3±0.8) in the non-indifferent group.The difference between the two groups was statistically significant (P=0.017). \u0000 \u0000 \u0000Conclusion \u0000Apathy has a high incidence in early Parkinson′s disease patients, often combined with fatigue and lack of interest symptoms.It has a serious impact on the quality of daily life in the future. \u0000 \u0000 \u0000Key words: \u0000Parkinson′s disease; Apathy; Unified Parkinson′s disease rating scale- III; Modified apathy evaluation scale; Montgomery-asberg depression rating scale; Mini-mental state examination; Non-motor symptom; Quality of life","PeriodicalId":10365,"journal":{"name":"Clinical Medicine of China","volume":"35 1","pages":"430-434"},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46436107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-01DOI: 10.3760/CMA.J.ISSN.1008-6315.2019.05.017
Menglan Wang, Junlian Liu, Yanhong Wang, Rui Zhong, S. Fei
Objective To analyze the serum gastric function and Helicobacter pylori (HP) infection in patients with gastric hyperplastic polyps and gastric fundic gland polyps. Methods From December 2017 to December 2018, 135 patients with gastric polyps and pathologically confirmed gastric hyperplastic polyps and gastric fundic gland polyps were enrolled in the hospital of Xuzhou Medical University.Among them, 68 patients with hyperplastic polyps, 67 cases of the gastric fundic gland polyps.Serum Hp antibodies (UreA, UreB, VacA, CagA antibodies) were qualitatively detected by immunoblotting.Eighty patients with chronic superficial gastritis were selected as the control group.Three groups of serum pepsinogen-I (PG-I), pepsinogen-Ⅱ (PG-Ⅱ), gastrin were detected by enzyme-linked immunosorbent assay (ELISA). Gastrin-17(G-17) and calculate PGⅠ and PGⅡ ratio(PGR). Results The levels of serum PGⅡ (13.13(8.15, 20.30) μg /L) and G17 (8.44(3.72, 27.17) pmol/L) in the gastric hyperplastic polyp group were higher than those in the control group (9.16(5.56, 15.14) μg/L and 1.83(0.87, 5.95) pmol/L) (P<0.05), and the PGR level was lower than the control group (P<0.05); serum PGI (120.12(86.72, 174.70) μg/L), PGII (11.92(7.27, 22.26) μg/L), G17 (5.68(1.79, 14.65) pmol/L) in the gastric fundic gland polyp group was higher than the control group ((101.32(79.17, 131.33) μg /L, 9.16(5.56, 15.14) μg /L, 1.83(0.87, 5.95) pmol/L)(P均<0.05)) (P<0.05); serum G17 (8.44(3.72, 27.17) pmol/L) level in gastric hyperplastic polyp group was higher than gastric fundus polyp group (5.68(1.79, 14.65) pmol/L) (P<0.05); Hp infection rate in gastric hyperplastic polyp group61.76%(42/68)was higher than that in the gastric fundic gland polyp group40.30%(27/67) (P<0.05), and type I Hp was the main one (P<0.05). The serum PGⅡ and G17 levels in the gastric hyperplastic polyp group were higher than those of Hp negative (all P<0.05). There were no significant differences in serum PGI, PGⅡ, G17, and PGR levels between the HP-positive and negative-positive patients in the gastric fundus polyp group.The serum PGI and PGR levels in the hypertrophic polyp group were higher than those in the HPⅡ type (all P<0.05). There was no significant difference in the levels of serum PGⅠ, PGⅡ, G17, and PGR between the gastric fundic gland polyps group and the type Ⅱ. Conclusion Serum PG and G17 levels in patients with gastric hypertrophic polyps and gastric fundic gland polyps are higher than those in patients with chronic superficial gastritis.Patients with gastric hyperplastic polyps have higher HP infection rate and abnormal gastric function than gastric fundic gland polyps. Key words: Gastric hyperplastic polyp; Gastric fundus polyp; Helicobacter pylori; pepsinogen; Gastrin
{"title":"Analysis of serum gastric function and Helicobacter pylori infection in patients with gastric hyperplastic polyps and gastric fundic gland polyps","authors":"Menglan Wang, Junlian Liu, Yanhong Wang, Rui Zhong, S. Fei","doi":"10.3760/CMA.J.ISSN.1008-6315.2019.05.017","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6315.2019.05.017","url":null,"abstract":"Objective \u0000To analyze the serum gastric function and Helicobacter pylori (HP) infection in patients with gastric hyperplastic polyps and gastric fundic gland polyps. \u0000 \u0000 \u0000Methods \u0000From December 2017 to December 2018, 135 patients with gastric polyps and pathologically confirmed gastric hyperplastic polyps and gastric fundic gland polyps were enrolled in the hospital of Xuzhou Medical University.Among them, 68 patients with hyperplastic polyps, 67 cases of the gastric fundic gland polyps.Serum Hp antibodies (UreA, UreB, VacA, CagA antibodies) were qualitatively detected by immunoblotting.Eighty patients with chronic superficial gastritis were selected as the control group.Three groups of serum pepsinogen-I (PG-I), pepsinogen-Ⅱ (PG-Ⅱ), gastrin were detected by enzyme-linked immunosorbent assay (ELISA). Gastrin-17(G-17) and calculate PGⅠ and PGⅡ ratio(PGR). \u0000 \u0000 \u0000Results \u0000The levels of serum PGⅡ (13.13(8.15, 20.30) μg /L) and G17 (8.44(3.72, 27.17) pmol/L) in the gastric hyperplastic polyp group were higher than those in the control group (9.16(5.56, 15.14) μg/L and 1.83(0.87, 5.95) pmol/L) (P<0.05), and the PGR level was lower than the control group (P<0.05); serum PGI (120.12(86.72, 174.70) μg/L), PGII (11.92(7.27, 22.26) μg/L), G17 (5.68(1.79, 14.65) pmol/L) in the gastric fundic gland polyp group was higher than the control group ((101.32(79.17, 131.33) μg /L, 9.16(5.56, 15.14) μg /L, 1.83(0.87, 5.95) pmol/L)(P均<0.05)) (P<0.05); serum G17 (8.44(3.72, 27.17) pmol/L) level in gastric hyperplastic polyp group was higher than gastric fundus polyp group (5.68(1.79, 14.65) pmol/L) (P<0.05); Hp infection rate in gastric hyperplastic polyp group61.76%(42/68)was higher than that in the gastric fundic gland polyp group40.30%(27/67) (P<0.05), and type I Hp was the main one (P<0.05). The serum PGⅡ and G17 levels in the gastric hyperplastic polyp group were higher than those of Hp negative (all P<0.05). There were no significant differences in serum PGI, PGⅡ, G17, and PGR levels between the HP-positive and negative-positive patients in the gastric fundus polyp group.The serum PGI and PGR levels in the hypertrophic polyp group were higher than those in the HPⅡ type (all P<0.05). There was no significant difference in the levels of serum PGⅠ, PGⅡ, G17, and PGR between the gastric fundic gland polyps group and the type Ⅱ. \u0000 \u0000 \u0000Conclusion \u0000Serum PG and G17 levels in patients with gastric hypertrophic polyps and gastric fundic gland polyps are higher than those in patients with chronic superficial gastritis.Patients with gastric hyperplastic polyps have higher HP infection rate and abnormal gastric function than gastric fundic gland polyps. \u0000 \u0000 \u0000Key words: \u0000Gastric hyperplastic polyp; Gastric fundus polyp; Helicobacter pylori; pepsinogen; Gastrin","PeriodicalId":10365,"journal":{"name":"Clinical Medicine of China","volume":"35 1","pages":"459-463"},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43661588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective To explore the effect of the position of the biliary stents on the short-term and long-term effects of the patients with low malignant obstructive jaundice after treatment. Methods Seventy-eight patients with low-grade malignant obstructive jaundice diagnosed in Jiangyin Hospital Affiliated to Medical College of Southeast University who underwent biliary stenting were enrolled as the study object.According to the placement of the biliary stents, the stents were divided into the spanning group and the non-crossing group.The baseline data and related serological indexes were recorded, and the changes of jaundice between the two groups were compared by repeated measurements.All patients were followed up for 48 weeks.Multivariate Cox regression analysis was applied on the risk factors that might affect the prognosis of patients, and the degree of influence of various factors on the prognosis of patients was further evaluated. Results Repeated measures analysis showed that the biochemical indicators of the spanning group and the non-crossing group showed a significant downward trend and the difference was statistically significant (TBil: Fintra-group=9.392, Pintra-group =0.000; DBil: Fintra-group=7.581, Pintra-group=0.001). Among them, the total bilirubin (TBil) (Preoperative: (318.69±101.13) μmol/L, 1 week after surgery: (135.98±63.61) μmol/L, 2 weeks after surgery: (60.21±24.81) μmol/L) was lower than the non-crossing group preoperative: (309.07±109.97) μmol/L, 1 week after surgery: (158.87±66.92) μmol/L, 2 weeks after surgery: (75.91±20.46) μmol/L), and the difference was statistically significant (Finter-group=3.362, Pinter-group=0.041). The direct bilirubin (DBil) (Preoperative: (171.93±73.01) μmol/L, 1 week after surgery: (90.38±57.33) μmol/L, 2 weeks after surgery: (36.64±18.95) μmol/L) was lower than the non-crossing group (Preoperative: (174.53±82.74) μmol/L, 1 week after surgery: (107.85±49.07) μmol/L, 2 weeks after surgery: (37.87±14.55) μmol/L.The difference was statistically significant (Finter-group=6.284, Pinter-group=0.003). There was an interaction between the treatment regimen and treatment time (1 week after surgery and 2 weeks after surgery) (TBil: Finteraction=12.262, Pinteraction=0.000; DBil: Finteraction=10.254, Pinteraction=0.000). The results of the multi factor Cox proportional hazard model of the spanning group and the non-crossing group showed that the ALP, DBil, TBil and lymphatic metastasis of malignant tumor were the two independent risk factors that affect the prognosis.However, the pancreatic cancer, ALT and age in the spanning group across the ampulla also have a certain effect on the prognosis of the patients. Conclusion The effect of the placement of biliary stents across the Vater ampullary was more obvious in the short term on the decline of bilirubin.But in the long term, there was no significant difference in the prognosis of patients with biliary stenting position.ALP, TBil, DBil, a
{"title":"The effect of biliary stent position on short-term and long-term outcomes of patients with low malignant obstructive jaundice after surgical treatment","authors":"Fulei Gao, Xiangzhong Huang, Dongqing Ren, Feng Gao, Guo-Dong Yuan","doi":"10.3760/CMA.J.ISSN.1008-6315.2019.05.001","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6315.2019.05.001","url":null,"abstract":"Objective \u0000To explore the effect of the position of the biliary stents on the short-term and long-term effects of the patients with low malignant obstructive jaundice after treatment. \u0000 \u0000 \u0000Methods \u0000Seventy-eight patients with low-grade malignant obstructive jaundice diagnosed in Jiangyin Hospital Affiliated to Medical College of Southeast University who underwent biliary stenting were enrolled as the study object.According to the placement of the biliary stents, the stents were divided into the spanning group and the non-crossing group.The baseline data and related serological indexes were recorded, and the changes of jaundice between the two groups were compared by repeated measurements.All patients were followed up for 48 weeks.Multivariate Cox regression analysis was applied on the risk factors that might affect the prognosis of patients, and the degree of influence of various factors on the prognosis of patients was further evaluated. \u0000 \u0000 \u0000Results \u0000Repeated measures analysis showed that the biochemical indicators of the spanning group and the non-crossing group showed a significant downward trend and the difference was statistically significant (TBil: Fintra-group=9.392, Pintra-group =0.000; DBil: Fintra-group=7.581, Pintra-group=0.001). Among them, the total bilirubin (TBil) (Preoperative: (318.69±101.13) μmol/L, 1 week after surgery: (135.98±63.61) μmol/L, 2 weeks after surgery: (60.21±24.81) μmol/L) was lower than the non-crossing group preoperative: (309.07±109.97) μmol/L, 1 week after surgery: (158.87±66.92) μmol/L, 2 weeks after surgery: (75.91±20.46) μmol/L), and the difference was statistically significant (Finter-group=3.362, Pinter-group=0.041). The direct bilirubin (DBil) (Preoperative: (171.93±73.01) μmol/L, 1 week after surgery: (90.38±57.33) μmol/L, 2 weeks after surgery: (36.64±18.95) μmol/L) was lower than the non-crossing group (Preoperative: (174.53±82.74) μmol/L, 1 week after surgery: (107.85±49.07) μmol/L, 2 weeks after surgery: (37.87±14.55) μmol/L.The difference was statistically significant (Finter-group=6.284, Pinter-group=0.003). There was an interaction between the treatment regimen and treatment time (1 week after surgery and 2 weeks after surgery) (TBil: Finteraction=12.262, Pinteraction=0.000; DBil: Finteraction=10.254, Pinteraction=0.000). The results of the multi factor Cox proportional hazard model of the spanning group and the non-crossing group showed that the ALP, DBil, TBil and lymphatic metastasis of malignant tumor were the two independent risk factors that affect the prognosis.However, the pancreatic cancer, ALT and age in the spanning group across the ampulla also have a certain effect on the prognosis of the patients. \u0000 \u0000 \u0000Conclusion \u0000The effect of the placement of biliary stents across the Vater ampullary was more obvious in the short term on the decline of bilirubin.But in the long term, there was no significant difference in the prognosis of patients with biliary stenting position.ALP, TBil, DBil, a","PeriodicalId":10365,"journal":{"name":"Clinical Medicine of China","volume":"35 1","pages":"385-390"},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42294376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-07-01DOI: 10.3760/CMA.J.ISSN.1008-6315.2019.04.010
Qi Zhou, Haiping Zhang
Objective To investigate the effects of garlicin capsule on immune function in patients with breast cancer undergoing chemotherapy. Methods Form April 2018 to October 2018, 62 patients with breast cancer were treated by operation in Tangshan People′s Hospital and pathologically diagnosed as breast cancer.Random number table method was used to divide the patients into treatment group and control group, with 31 cases in each group.The treatment group was given garlicin capsule combined with EC regimen( the first day(epirubicin hydrochloride injection 90 mg/m2 + cyclophosphamide 90 mg/m2) , 21 days for one cycle, four consecutive cycles), while the control group was given EC regimen alone for 4 courses.The occurrence of adverse reactions was recorded.T lymphocyte subsets were detected before and after treatment to evaluate the immune function of the body. Results There was no significant difference in the number of adverse reactions between the two groups after treatment (Seventy in the treatment group and 69 in the control group) (P>0.05). The levels of CD3+ , CD4+ , CD8+ and CD4+ /CD8+ were (53.76±4.29)%, (40.19±3.71)%, (28.61±2.75)% and (1.41±0.16) in the treatment group before chemotherapy, respectively.While after chemotherapy were (52.41±4.44)%, (39.49±4.06)%, (28.70±2.76)% and (1.35±0.94), respectively.The levels of CD3+ , CD4+ , CD8+ and CD4+ /CD8+ were (54.35±4.09)%, (40.70±4.09)%, (27.62±3.60)% and (1.49±0.24) in the control group before chemotherapy, respectively.While after chemotherapy were (44.27±6.67)%, (35.39±4.96)%, (30.48±3.43)% and (1.17±0.20). After treatment, the levels of CD3+ , CD4+ , CD4+ / CD8+ decreased and CD8+ increased, but there had no significant difference(P>0.05). After treatment, CD3+ (decreased from(54.35±4.09)% to (44.27±6.67)%), CD4+ (decreased from (40.70±4.09)% to (35.39±4.96)%), CD4+ /CD8+ ((decreased from (1.49±0.24) to (1.17±0.20)), the difference was statistically significant(t value was 7.17, 4.60, 5.71, -3.02, P value was 0.000, 0.000, 0.002, 0.000). Compared with control group, the levels of CD3+ 、CD4+ 、CD4+ / CD8+ in treatment group increased and CD8+ decreased significantly (all P<0.01). Conclusion Garlicin capsule can improve the depression of immune function caused by chemotherapy. Key words: Breast cancer; Garlicin capsule; Chemotherapy; Immune function
{"title":"Effect of Garlicin Capsule on Cellular Immune Function in Patients with Breast Cancer undergoing Chemotherapy","authors":"Qi Zhou, Haiping Zhang","doi":"10.3760/CMA.J.ISSN.1008-6315.2019.04.010","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6315.2019.04.010","url":null,"abstract":"Objective \u0000To investigate the effects of garlicin capsule on immune function in patients with breast cancer undergoing chemotherapy. \u0000 \u0000 \u0000Methods \u0000Form April 2018 to October 2018, 62 patients with breast cancer were treated by operation in Tangshan People′s Hospital and pathologically diagnosed as breast cancer.Random number table method was used to divide the patients into treatment group and control group, with 31 cases in each group.The treatment group was given garlicin capsule combined with EC regimen( the first day(epirubicin hydrochloride injection 90 mg/m2 + cyclophosphamide 90 mg/m2) , 21 days for one cycle, four consecutive cycles), while the control group was given EC regimen alone for 4 courses.The occurrence of adverse reactions was recorded.T lymphocyte subsets were detected before and after treatment to evaluate the immune function of the body. \u0000 \u0000 \u0000Results \u0000There was no significant difference in the number of adverse reactions between the two groups after treatment (Seventy in the treatment group and 69 in the control group) (P>0.05). The levels of CD3+ , CD4+ , CD8+ and CD4+ /CD8+ were (53.76±4.29)%, (40.19±3.71)%, (28.61±2.75)% and (1.41±0.16) in the treatment group before chemotherapy, respectively.While after chemotherapy were (52.41±4.44)%, (39.49±4.06)%, (28.70±2.76)% and (1.35±0.94), respectively.The levels of CD3+ , CD4+ , CD8+ and CD4+ /CD8+ were (54.35±4.09)%, (40.70±4.09)%, (27.62±3.60)% and (1.49±0.24) in the control group before chemotherapy, respectively.While after chemotherapy were (44.27±6.67)%, (35.39±4.96)%, (30.48±3.43)% and (1.17±0.20). After treatment, the levels of CD3+ , CD4+ , CD4+ / CD8+ decreased and CD8+ increased, but there had no significant difference(P>0.05). After treatment, CD3+ (decreased from(54.35±4.09)% to (44.27±6.67)%), CD4+ (decreased from (40.70±4.09)% to (35.39±4.96)%), CD4+ /CD8+ ((decreased from (1.49±0.24) to (1.17±0.20)), the difference was statistically significant(t value was 7.17, 4.60, 5.71, -3.02, P value was 0.000, 0.000, 0.002, 0.000). Compared with control group, the levels of CD3+ 、CD4+ 、CD4+ / CD8+ in treatment group increased and CD8+ decreased significantly (all P<0.01). \u0000 \u0000 \u0000Conclusion \u0000Garlicin capsule can improve the depression of immune function caused by chemotherapy. \u0000 \u0000 \u0000Key words: \u0000Breast cancer; Garlicin capsule; Chemotherapy; Immune function","PeriodicalId":10365,"journal":{"name":"Clinical Medicine of China","volume":"35 1","pages":"337-341"},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42238037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-07-01DOI: 10.3760/CMA.J.ISSN.1008-6315.2019.04.016
B. Ma, N. Cao
Objective To evaluate the clinical effect of modified Overlap method in digestive tract reconstruction of totally laparoscopic total gastrectomy(TLTG) for gastric cancer. Methods The data of 86 patients with gastric cancer who underwent TLTG from January 2014 and January 2017 were collected from the First Hospital of Lanzhou University.All the patients underwent D2 lymphadenectomy.Forty-four patients′ digestive tracts were reconstructed with traditional Overlap method (control group), and 42 patients′ digestive tracts were reconstructed with modified Overlap method (modified group). The intraoperative and postoperative conditions, postoperative tumor-free survival, tumor recurrence and metastasis were compared between the two groups.Follow up lasted as of February 2018. Results TLTG was successfully performed in both groups, and no case was converted to laparotomy.The time of esophagojejunostomy ((20.4±2.3) min vs.(46.5±4.4) min, t=9.493), total operation time ((253.3±12.8) min vs.(278.6±14.9) min, t=5.462) in the modified group were significantly shorter than those in the control group, and there were significant differences between the two groups (all P 0.05). The two groups were followed up for 12~25 months.No recurrence or metastasis occurred. Conclusion Compared with traditional Overlap method, the modified Overlap method can simplify the anastomotic procedures, shorten operation time and achieve an effective and reliable anastomosis effect after TLTG. Key words: Gastric neoplasms; Laparoscopy; Radical surgery; Esophagojejunostomy
{"title":"Evaluation of modified Overlap method in digestive tract reconstruction after totally laparoscopic total gastrectomy for gastric cancer","authors":"B. Ma, N. Cao","doi":"10.3760/CMA.J.ISSN.1008-6315.2019.04.016","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6315.2019.04.016","url":null,"abstract":"Objective \u0000To evaluate the clinical effect of modified Overlap method in digestive tract reconstruction of totally laparoscopic total gastrectomy(TLTG) for gastric cancer. \u0000 \u0000 \u0000Methods \u0000The data of 86 patients with gastric cancer who underwent TLTG from January 2014 and January 2017 were collected from the First Hospital of Lanzhou University.All the patients underwent D2 lymphadenectomy.Forty-four patients′ digestive tracts were reconstructed with traditional Overlap method (control group), and 42 patients′ digestive tracts were reconstructed with modified Overlap method (modified group). The intraoperative and postoperative conditions, postoperative tumor-free survival, tumor recurrence and metastasis were compared between the two groups.Follow up lasted as of February 2018. \u0000 \u0000 \u0000Results \u0000TLTG was successfully performed in both groups, and no case was converted to laparotomy.The time of esophagojejunostomy ((20.4±2.3) min vs.(46.5±4.4) min, t=9.493), total operation time ((253.3±12.8) min vs.(278.6±14.9) min, t=5.462) in the modified group were significantly shorter than those in the control group, and there were significant differences between the two groups (all P 0.05). The two groups were followed up for 12~25 months.No recurrence or metastasis occurred. \u0000 \u0000 \u0000Conclusion \u0000Compared with traditional Overlap method, the modified Overlap method can simplify the anastomotic procedures, shorten operation time and achieve an effective and reliable anastomosis effect after TLTG. \u0000 \u0000 \u0000Key words: \u0000Gastric neoplasms; Laparoscopy; Radical surgery; Esophagojejunostomy","PeriodicalId":10365,"journal":{"name":"Clinical Medicine of China","volume":"35 1","pages":"364-367"},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47695266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-07-01DOI: 10.3760/CMA.J.ISSN.1008-6315.2019.04.003
Liang Chen, Jing Zhang, Xiao-Jie Shi, Zhizhong Liu, Yanyan Sun
Objective To investigate the effect of vitamin D on platelet reactivity after combined treatment with aspirin and clopidogrel in elderly patients with ischemic stroke. Methods A total of 190 elderly patients with ischemic stroke treated with aspirin and clopidogrel in Beijing Bo′ai Hospital from June 2017 to August 2018 were enrolled in this study.Venous blood was collected for platelet aggregation rate, 25-hydroxyvitamin D[25(OH)D] and clinical biochemical indexes during 1~2 weeks.According to 25 (OH) D quartile, the patients were further divided into Q1(≤7.18 μg/L) group (n=50), Q2: (>7.18-≤9.39 μg/L) group (n=50), Q3: (>9.39-≤13.74 μg/L) group (50), Q4: (>13.74 μg/L) (n=40). In order to evaluate the effect of calcitriol on platelet aggregation, platelet rich plasma (PRP) in healthy group (15 cases) and clopidogrel resistance group (15 cases) were treated with calcitriol (10 nmol/L) and saline (37 ℃ pretreatment for 5 minutes), respectively, and to compare the difference of maximum platelet aggregation rate induced by ADP between the two treatments. Results There were significant differences in ADP-induced maximum platelet aggregation rate (MPAR) ((49.36±23.34)%, (48.80±20.90)%, (37.02±18.24)%, (36.02±14.46)%, F=3.426, P=0.018) and clopidogrel resistance (CR)/ clopidogrel sensitive (CS) ratio (30/20, 24/26, 15/35, 10/30, χ2=15.119, P=0.002) among the vitamin D quartiles (increasing). Moreover, the MPAR and CR showed a decreasing trend with the increase of vitamin D concentration.Logistic regression analysis showed that serum 25(OH)D level was an independent inhibited factor for clopidogrel resistance in elderly patients with ischemic stroke (Q4 vs Q1, OR=0.699, 95%CI 0.582~0.838, P<0.001; Q3 vs Q1, OR=0.848, 95%CI 0.755-0.953, P=0.006). In vitro, compared with physiological saline, the aggregation rates of platelet in healthy group and CR group decreased after calcitriol pretreatment, and the difference was statistically significant(healthy group: (69.8±12.7)% vs (58.6±11.5)%, t=12.13, P<0.001; CR group: (65.5±8.3)% vs (56.3±7.6)%, t=11.48, P<0.001). Conclusion Vitamin D reduces the high residual platelet reactivity after antiplatelet therapy.Further study is needed to determine whether vitamin D supplementation may improve the efficacy of clopidogrel. Key words: Ischemic stroke; Antiplatelet therapy; Vitamin D; Drug resistance
{"title":"Effect of vitamin D on antiplatelet drug responsiveness in elderly patients with ischemic stroke","authors":"Liang Chen, Jing Zhang, Xiao-Jie Shi, Zhizhong Liu, Yanyan Sun","doi":"10.3760/CMA.J.ISSN.1008-6315.2019.04.003","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6315.2019.04.003","url":null,"abstract":"Objective \u0000To investigate the effect of vitamin D on platelet reactivity after combined treatment with aspirin and clopidogrel in elderly patients with ischemic stroke. \u0000 \u0000 \u0000Methods \u0000A total of 190 elderly patients with ischemic stroke treated with aspirin and clopidogrel in Beijing Bo′ai Hospital from June 2017 to August 2018 were enrolled in this study.Venous blood was collected for platelet aggregation rate, 25-hydroxyvitamin D[25(OH)D] and clinical biochemical indexes during 1~2 weeks.According to 25 (OH) D quartile, the patients were further divided into Q1(≤7.18 μg/L) group (n=50), Q2: (>7.18-≤9.39 μg/L) group (n=50), Q3: (>9.39-≤13.74 μg/L) group (50), Q4: (>13.74 μg/L) (n=40). In order to evaluate the effect of calcitriol on platelet aggregation, platelet rich plasma (PRP) in healthy group (15 cases) and clopidogrel resistance group (15 cases) were treated with calcitriol (10 nmol/L) and saline (37 ℃ pretreatment for 5 minutes), respectively, and to compare the difference of maximum platelet aggregation rate induced by ADP between the two treatments. \u0000 \u0000 \u0000Results \u0000There were significant differences in ADP-induced maximum platelet aggregation rate (MPAR) ((49.36±23.34)%, (48.80±20.90)%, (37.02±18.24)%, (36.02±14.46)%, F=3.426, P=0.018) and clopidogrel resistance (CR)/ clopidogrel sensitive (CS) ratio (30/20, 24/26, 15/35, 10/30, χ2=15.119, P=0.002) among the vitamin D quartiles (increasing). Moreover, the MPAR and CR showed a decreasing trend with the increase of vitamin D concentration.Logistic regression analysis showed that serum 25(OH)D level was an independent inhibited factor for clopidogrel resistance in elderly patients with ischemic stroke (Q4 vs Q1, OR=0.699, 95%CI 0.582~0.838, P<0.001; Q3 vs Q1, OR=0.848, 95%CI 0.755-0.953, P=0.006). In vitro, compared with physiological saline, the aggregation rates of platelet in healthy group and CR group decreased after calcitriol pretreatment, and the difference was statistically significant(healthy group: (69.8±12.7)% vs (58.6±11.5)%, t=12.13, P<0.001; CR group: (65.5±8.3)% vs (56.3±7.6)%, t=11.48, P<0.001). \u0000 \u0000 \u0000Conclusion \u0000Vitamin D reduces the high residual platelet reactivity after antiplatelet therapy.Further study is needed to determine whether vitamin D supplementation may improve the efficacy of clopidogrel. \u0000 \u0000 \u0000Key words: \u0000Ischemic stroke; Antiplatelet therapy; Vitamin D; Drug resistance","PeriodicalId":10365,"journal":{"name":"Clinical Medicine of China","volume":"35 1","pages":"300-305"},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45398593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-07-01DOI: 10.3760/CMA.J.ISSN.1008-6315.2019.04.013
Jie Chen, Bin Zhao, Jun Li, Gaofeng Zhang
Objective To study the effect of laparoscopic hepatectomy resection on immune function, inflammatory factors and prognosis of patients. Methods One hundred and four patients with hepatocellular carcinoma admitted Zigong Fourth People′s Hospital from July 2015 to December 2016 were selected as the study subjects.According to the different surgical methods, they were randomly divided into observation group and control group with 52 cases in each group.The control group received open hepatectomy, while the observation group received laparoscopic hepatectomy.The immune function, inflammatory factors, and surgery related indicators were compared between the two groups. Results The observation time of the observation group was significantly longer than that in the control group.The blood loss was significantly less than the control group.Gastrointestinal function recovery time and postoperative hospital stay were significantly shorter than control group (t=7.553, 13.855, 15.100, 16.873, all P<0.01), three days after surgery, the serum IgA, IgG, and IgM levels were significantly higher than control group (t=16.009, 10.076, 14.138, all P<0.01). The levels of IL-6, IL-10 and TNF-α were significantly lower than the control group (t=8.538, 6.851, 11.103, P<0.05, all P<0.01). Conclusion Laparoscopic hepatectomy can promote the recovery of patients after surgery, which may be related to the reduction of immune function inhibition, inflammatory response and other factors. Key words: Liver cancer; Surgical resection; Laparoscopy; Immune function; Inflammatory factors
{"title":"Effect of laparoscopic hepatectomy on immune function, inflammatory factors and prognosis of patients with hepatocellular carcinoma","authors":"Jie Chen, Bin Zhao, Jun Li, Gaofeng Zhang","doi":"10.3760/CMA.J.ISSN.1008-6315.2019.04.013","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6315.2019.04.013","url":null,"abstract":"Objective \u0000To study the effect of laparoscopic hepatectomy resection on immune function, inflammatory factors and prognosis of patients. \u0000 \u0000 \u0000Methods \u0000One hundred and four patients with hepatocellular carcinoma admitted Zigong Fourth People′s Hospital from July 2015 to December 2016 were selected as the study subjects.According to the different surgical methods, they were randomly divided into observation group and control group with 52 cases in each group.The control group received open hepatectomy, while the observation group received laparoscopic hepatectomy.The immune function, inflammatory factors, and surgery related indicators were compared between the two groups. \u0000 \u0000 \u0000Results \u0000The observation time of the observation group was significantly longer than that in the control group.The blood loss was significantly less than the control group.Gastrointestinal function recovery time and postoperative hospital stay were significantly shorter than control group (t=7.553, 13.855, 15.100, 16.873, all P<0.01), three days after surgery, the serum IgA, IgG, and IgM levels were significantly higher than control group (t=16.009, 10.076, 14.138, all P<0.01). The levels of IL-6, IL-10 and TNF-α were significantly lower than the control group (t=8.538, 6.851, 11.103, P<0.05, all P<0.01). \u0000 \u0000 \u0000Conclusion \u0000Laparoscopic hepatectomy can promote the recovery of patients after surgery, which may be related to the reduction of immune function inhibition, inflammatory response and other factors. \u0000 \u0000 \u0000Key words: \u0000Liver cancer; Surgical resection; Laparoscopy; Immune function; Inflammatory factors","PeriodicalId":10365,"journal":{"name":"Clinical Medicine of China","volume":"35 1","pages":"350-353"},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45572032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-07-01DOI: 10.3760/CMA.J.ISSN.1008-6315.2019.04.005
Jie-rui Wang, Hui-jing Shi, Wen-hao Yang, Na Li, Wenfang Yang, Jian Wang, W. Yuan, Bai-lu Liu, Yuqin Hu, Lina Li, R. Shu, Haichen Song, Yixuan Han, P. Yu
Objective To investigate the relationship between serum uric acid (UA) level and brachial-ankle pulse wave velocity (baPWV) in patients with systemic lupus erythematosus (SLE) and lupus nephritis (LN). Methods A total of 110 hospitalized, out-patient and healthy examinees from January 2017 to September 2017 were selected from Kailuan General Hospital.They were divided into three groups: (1)Fifty-five healthy controls were examined at the same time, and those who had no history of hypertension, myocardial infarction and stroke were excluded by physical examination.(2)Thirty-four SLE patients without LN were diagnosed according to the SLE classification standard revised by the American Society of Rheumatology (ACR) in 1997, excluding those with lupus nephritis.(3)21 SLE patients with LN were diagnosed according to the SLE classification standard revised by the American Society of Rheumatology (ACR) in 1997.Pearson correlation coefficient and multivariate linear regression model were used to analyze the related factors affecting baPWV. Results The level of baPWV and the proportion of baPWV (≥1400 cm/s) in SLE without LN group and SLE with LN group were higher than those in healthy control group (all P<0.05). In SLE without LN group, baPWV was positively correlated with age, systolic blood pressure(SBP)and total cholesterol(CHOL)(r=0.623, 0.528, 0.402, P<0.01 or P<0.05), and negatively correlated with blood uric acid(UA) (r=-0.371, P<0.05), but the correlation was not significant.The correlation between UA and baPWV disappeared after after correction of age, SBP, diastolic blood pressure (DBP) by partial correlation analysis.In SLE with LN group, baPWV was positively correlated with SBP, DBP and serum creatinine(Cr) (r=0.815, 0.725, 0.464, P<0.01 or P<0.05). Multivariate stepwise regression analysis showed that SBP was independently correlated with baPWV in SLE group (t=2.54, P=0.026); UA in SLE group without LN was independently negatively correlated with baPWV(t=-2.96, P=0.042); UA(t=4.24, P=0.013) and SBP(t=7.70, P=0.002) were independently positively correlated with baPWV in SLE group with LN.Logistic regression analysis showed that SLE was a risk factor for baPWV (≥1 400 cm/s), and the OR (95% CI) was 4.31 (1.56-11.88), P=0.005, and there was statistical significance after adjusting for age, SBP, DBP, body mass index (BMI). However, UA was not a risk factor for baPWV (≥ 1 400 cm/s) (P values were 0.163 and 0.519, respectively). Conclusion The degree of arteriosclerosis in SLE patients is higher than that in normal subjects, and the level of UA in SLE patients may be related to baPWV. Key words: Systemic lupus erythematosus; Lupus nephritis; Blood uric acid; Brachial-ankle pulse wave velocity
目的探讨系统性红斑狼疮(SLE)和狼疮肾炎(LN)患者血清尿酸(UA)水平与肱-踝脉波速度(baPWV)的关系。方法选取2017年1月至2017年9月开滦总医院住院、门诊及健康体检者110人。他们被分为三组:(1)同期健康对照55例，体检排除无高血压、心肌梗死、脑卒中病史者。(2)34例无LN的SLE患者按照1997年美国风湿病学会(ACR)修订的SLE分类标准进行诊断。(3)根据1997年美国风湿病学会(American Society of Rheumatology, ACR)修订的SLE分类标准诊断SLE合并LN患者21例。采用Pearson相关系数和多元线性回归模型分析影响baPWV的相关因素。结果SLE无LN组和SLE合并LN组患者血清baPWV水平及baPWV≥1400 cm/s的比例均高于健康对照组(P<0.05)。在无LN的SLE组中，baPWV与年龄、收缩压(SBP)、总胆固醇(CHOL)呈正相关(r=0.623、0.528、0.402,P<0.01或P<0.05)，与血尿酸(UA)负相关(r=-0.371, P<0.05)，但相关性不显著。偏相关分析校正年龄、收缩压、舒张压后，UA与baPWV的相关性消失。SLE合并LN组baPWV与收缩压、舒张压、血清肌酐(Cr)呈正相关(r=0.815、0.725、0.464,P<0.01或P<0.05)。多因素逐步回归分析显示SLE组收缩压与baPWV独立相关(t=2.54, P=0.026);无LN的SLE组UA与baPWV呈独立负相关(t=-2.96, P=0.042);SLE合并LN组UA(t=4.24, P=0.013)、SBP(t=7.70, P=0.002)与baPWV独立正相关。Logistic回归分析显示SLE是baPWV(≥1 400 cm/s)的危险因素，OR (95% CI)为4.31 (1.56 ~ 11.88)，P=0.005，校正年龄、收缩压、舒张压、体重指数(BMI)后差异有统计学意义。然而，UA不是baPWV(≥1 400 cm/s)的危险因素(P值分别为0.163和0.519)。结论SLE患者动脉硬化程度高于正常人，SLE患者UA水平可能与baPWV有关。关键词:系统性红斑狼疮;狼疮肾炎;血尿酸;肱-踝脉波速度
{"title":"Study on correlation between serum uric acid level and brachial ankle pulse wave velocity in patients with systemic lupus erythematosus","authors":"Jie-rui Wang, Hui-jing Shi, Wen-hao Yang, Na Li, Wenfang Yang, Jian Wang, W. Yuan, Bai-lu Liu, Yuqin Hu, Lina Li, R. Shu, Haichen Song, Yixuan Han, P. Yu","doi":"10.3760/CMA.J.ISSN.1008-6315.2019.04.005","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6315.2019.04.005","url":null,"abstract":"Objective \u0000To investigate the relationship between serum uric acid (UA) level and brachial-ankle pulse wave velocity (baPWV) in patients with systemic lupus erythematosus (SLE) and lupus nephritis (LN). \u0000 \u0000 \u0000Methods \u0000A total of 110 hospitalized, out-patient and healthy examinees from January 2017 to September 2017 were selected from Kailuan General Hospital.They were divided into three groups: (1)Fifty-five healthy controls were examined at the same time, and those who had no history of hypertension, myocardial infarction and stroke were excluded by physical examination.(2)Thirty-four SLE patients without LN were diagnosed according to the SLE classification standard revised by the American Society of Rheumatology (ACR) in 1997, excluding those with lupus nephritis.(3)21 SLE patients with LN were diagnosed according to the SLE classification standard revised by the American Society of Rheumatology (ACR) in 1997.Pearson correlation coefficient and multivariate linear regression model were used to analyze the related factors affecting baPWV. \u0000 \u0000 \u0000Results \u0000The level of baPWV and the proportion of baPWV (≥1400 cm/s) in SLE without LN group and SLE with LN group were higher than those in healthy control group (all P<0.05). In SLE without LN group, baPWV was positively correlated with age, systolic blood pressure(SBP)and total cholesterol(CHOL)(r=0.623, 0.528, 0.402, P<0.01 or P<0.05), and negatively correlated with blood uric acid(UA) (r=-0.371, P<0.05), but the correlation was not significant.The correlation between UA and baPWV disappeared after after correction of age, SBP, diastolic blood pressure (DBP) by partial correlation analysis.In SLE with LN group, baPWV was positively correlated with SBP, DBP and serum creatinine(Cr) (r=0.815, 0.725, 0.464, P<0.01 or P<0.05). Multivariate stepwise regression analysis showed that SBP was independently correlated with baPWV in SLE group (t=2.54, P=0.026); UA in SLE group without LN was independently negatively correlated with baPWV(t=-2.96, P=0.042); UA(t=4.24, P=0.013) and SBP(t=7.70, P=0.002) were independently positively correlated with baPWV in SLE group with LN.Logistic regression analysis showed that SLE was a risk factor for baPWV (≥1 400 cm/s), and the OR (95% CI) was 4.31 (1.56-11.88), P=0.005, and there was statistical significance after adjusting for age, SBP, DBP, body mass index (BMI). However, UA was not a risk factor for baPWV (≥ 1 400 cm/s) (P values were 0.163 and 0.519, respectively). \u0000 \u0000 \u0000Conclusion \u0000The degree of arteriosclerosis in SLE patients is higher than that in normal subjects, and the level of UA in SLE patients may be related to baPWV. \u0000 \u0000 \u0000Key words: \u0000Systemic lupus erythematosus; Lupus nephritis; Blood uric acid; Brachial-ankle pulse wave velocity","PeriodicalId":10365,"journal":{"name":"Clinical Medicine of China","volume":"35 1","pages":"311-316"},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41581543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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