Clinical Oral Implants Research最新文献_第7页

Prognosis of Single Implant-Supported Prosthesis in Patients With Primary Sjögren's Syndrome: A Five-Year Prospective Clinical Study 原发性 Sjögren's 综合征患者单种植体支持假体的预后：一项为期五年的前瞻性临床研究。

IF 4.8 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical Oral Implants Research

Pub Date : 2024-09-05 DOI: 10.1111/clr.14356

Mandana Hosseini, Simon Storgård Jensen, Klaus Gotfredsen, Emil Hyldahl, Anne Marie Lynge Pedersen

Background

Primary Sjögren's syndrome (pSS) is a chronic systemic autoimmune disease characterized by hyposalivation. Currently, there is limited evidence for the prognosis of dental implant treatment in Sjögren's syndrome.

Aim/Hypothesis

We hypothesized comparable clinical outcomes of implant-supported restorations in pSS-patients and control subjects, and improvement in oral health-related quality of life 5 years after restoration.

Material and Methods

Patients with pSS and matched (age, gender, and tooth region) control group were recruited between June 2016 and March 2020. The clinical and radiological examination were performed, and patient-reported oral health impact profile (OHIP-49) questionnaire was used 2 months (baseline), 1, 3, and 5 years after prosthetic treatment.

Results

We included 23 patients with pSS and 24 matched control subjects (all women, mean age: 57.1 years). The overall DMFT (decayed-missed-filled-tooth) was significantly higher (p = 0.008), symptoms of dry mouth were more severe (p = 0.001), and unstimulated and chewing-stimulated saliva flow rates were significantly lower (p < 0.001) in pSS than in control group. All implants survived with no implant mobility. At implant sites, the plaque index and probing depths did not differ (p = 0.301 and 0.446, respectively), but the gingival index was significantly higher (p = 0.003) in pSS than control group. The mean marginal bone loss, prosthetic complications, and clinician-reported aesthetic outcomes were similar in both groups after 5 years. The OHIP scores were significantly higher in the pSS than control group (p < 0.001) but reduced significantly in both groups (p = 0.026).

Conclusion

Replacement of missing single teeth with dental implants was successful in patients with pSS 5 years after restoration.

背景：原发性斯约格伦综合征（pSS）是一种以唾液分泌过少为特征的慢性全身性自身免疫性疾病。目前，有关斯约格伦综合征患者种植牙治疗预后的证据有限：目的/假设：我们假设斯约格伦综合征患者和对照组患者种植体支持修复的临床效果相当，且修复后 5 年口腔健康相关生活质量有所改善：在 2016 年 6 月至 2020 年 3 月期间招募 pSS 患者和匹配（年龄、性别和牙区）的对照组。进行临床和放射学检查，并在修复治疗后2个月（基线）、1年、3年和5年使用患者报告的口腔健康影响档案（OHIP-49）问卷：我们纳入了 23 名 pSS 患者和 24 名匹配的对照组受试者（均为女性，平均年龄：57.1 岁）。总的 DMFT（龋坏-缺失-充填牙）明显更高（p = 0.008），口干症状更严重（p = 0.001），非刺激唾液流率和咀嚼刺激唾液流率明显更低（p 结论：龋坏-缺失-充填牙患者的唾液流率和咀嚼刺激唾液流率均显著高于对照组：用种植牙修复缺失的单颗牙齿在修复 5 年后对 pSS 患者是成功的。

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引用次数: 0

Comparison of Different Intraoral Scanners With Prefabricated Aid on Accuracy and Framework Passive Fit of Digital Complete-Arch Implant Impression: An In Vitro Study 不同口内扫描仪与预制辅助工具在数字化全口种植体印模的准确性和骨架被动配合上的比较：体外研究。

IF 4.8 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical Oral Implants Research

Pub Date : 2024-09-04 DOI: 10.1111/clr.14353

Xiao-Jiao Fu, Min Liu, Jun-Yu Shi, Ke Deng, Hong-Chang Lai, Wen Gu, Xiao-Meng Zhang

Objectives

This study aimed to compare the accuracy of digital complete-arch implant impressions with prefabricated aids using three intraoral scanners (IOSs) and explore the correlation between virtual deviation measurement and physical framework misfit.

Materials and Methods

Four edentulous maxillary master models with four and six parallel and angular implants were fabricated and scanned by a laboratory scanner as reference scans. Ten scans of each master model were acquired using three IOSs (IOS-T, IOS-M, and IOS-A) with and without prefabricated aids. Trueness and precision of root mean square (RMS) errors were measured. Ten aluminum alloy frameworks were fabricated, and the misfit was measured with a micro-computed tomography scan with one screw tightened.

Results

Trueness and precision showed significant improvement when prefabricated aids were used for all three IOSs (p < 0.010). Median (interquartile range) RMS errors of trueness reduced from 67.5 (30.4) to 61.8 (30.3) μm, from 100.6 (35.4) to 45.9 (15.1) μm, and from 52.7 (33.2) to 41.1 (22.5) μm for scanner IOS-T, IOS-M, and IOS-A, respectively (p < 0.010). The precision of IOS-A and IOS-M was significantly better than IOS-T when using prefabricated aid (p < 0.001). RMS errors and the maximum marginal misfit of the framework were significantly correlated (p < 0.001, R² = 0.845).

Conclusions

With the prefabricated aids, the accuracy of IOSs enhanced significantly in digital complete-arch implant impressions. Three IOSs showed different levels of improvement in accuracy. Virtual RMS errors <62.2 μm could be the clinically acceptable threshold (150 μm) for framework passive fit.

研究目的：本研究旨在比较使用三种口内扫描仪（IOS）制作的数字化全牙弓种植体印模与预制辅助工具的准确性，并探讨虚拟偏差测量与物理框架错位之间的相关性：制作了四个无牙上颌主模型，分别带有四个和六个平行和角度种植体，并用实验室扫描仪扫描作为参考扫描。使用三种 IOS（IOS-T、IOS-M 和 IOS-A）对每个主模型进行 10 次扫描，包括预制辅助装置和未预制辅助装置。测量了均方根误差的真实度和精确度。制作了 10 个铝合金框架，并在拧紧一个螺钉的情况下通过微型计算机断层扫描测量了错位情况：结果：在所有三个 IOS 中使用预制辅助装置时，真实度和精确度都有明显改善（p 2 = 0.845）：结论：使用预制辅助工具后，数字化全牙弓种植体印模的 IOS 精确度明显提高。三种 IOS 的精确度都有不同程度的提高。虚拟均方根误差

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引用次数: 0

Pull-Off Forces on Implant-Supported Single Restorations by Sticky Food: An In Vitro Study 粘性食物对种植体支撑的单颗修复体的拉脱力：体外研究

IF 4.8 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical Oral Implants Research

Pub Date : 2024-08-29 DOI: 10.1111/clr.14355

Shaza Bishti, Martin Homa, Stefan Wolfart, Taskin Tuna

Objective

To investigate the pull-off forces on implant-supported restorations caused by sticky food, to understand how much retention force cemented restorations must have to withstand chewing forces without unintentional retention loss. The influence of food type, restoration design, and surface treatment were investigated.

Material and Methods

Monolithic implant-supported CAD/CAM zirconia crowns were fabricated and divided into groups according to their design: no (NC), flat (FC) and high cusps (HC) and subdivided according to surface roughness: rough (r) and smooth (s) (n = 10/group). NC represented the control group. The crowns were fixed in a universal testing machine opposite to each other. Four sticky foods (caramel, fruit jelly, candy strips and licorice) and a resin crown remover were tested. These were heated (36.4°C), placed between the crowns and compressed, then tensile strength tests were performed. The maximum pull-off force was recorded (Newton [N]). Statistical analysis was performed using 3-way ANOVA.

Results

The highest mean pull-off force among food samples was with caramel_HC_r (12.09 ± 1.26 N), whereas the lowest was with licorice_FC_s (3.21 ± 0.15 N). For the resin crown remover, a mean pull-off force of 55.41 ± 3.87 N was measured in the HC_r group. Both food type and crown design showed a significant influence on pull-off force (p < 0.001), whereas no significant effect was reported with different surface roughnesses (p = 0.344).

Conclusion

This study reported pull-off forces of up to 20 N between all-ceramic restorations caused by sticky food. The clinical implication of these findings is that a cemented implant-restoration must have a minimum retention force of 20 N to withstand unintentional displacement during function.

目的研究粘性食物对种植体支持修复体的拉脱力，以了解粘结修复体必须具有多大的固位力才能承受咀嚼力而不发生意外固位力丧失。材料和方法制作单体种植体支持的 CAD/CAM 氧化锆冠，并根据其设计分为三组：无尖牙（NC）、平尖牙（FC）和高尖牙（HC），并根据表面粗糙度细分为粗糙（R）和光滑（S）（n = 10/组）。NC 代表对照组。牙冠相对固定在万能试验机上。测试了四种粘性食物（焦糖、果冻、糖条和甘草）和一种树脂牙冠去除剂。将这些食物加热（36.4°C），放在牙冠之间并压缩，然后进行拉伸强度测试。记录最大拉拔力（牛顿[N]）。结果焦糖_HC_r 的平均拉拔力最高（12.09 ± 1.26 N），而甘草_FC_s 的平均拉拔力最低（3.21 ± 0.15 N）。在树脂牙冠去除器中，HC_r 组的平均拉拔力为 55.41 ± 3.87 N。食物类型和牙冠设计都对拉脱力有显著影响（p <0.001），而不同的表面粗糙度则没有显著影响（p = 0.344）。这些研究结果的临床意义在于，粘结种植体修复体必须至少具有 20 N 的固位力，以承受功能过程中的意外移位。

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引用次数: 0

In vitro assessment of cementation of CAD/CAM fabricated prostheses over titanium bases. A systematic review CAD/CAM制作的修复体在钛基底上的粘接体外评估。系统综述。

IF 4.8 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical Oral Implants Research

Pub Date : 2024-08-27 DOI: 10.1111/clr.14347

Panagiotis Ntovas, Ourania Ladia, Aspasia Pachiou, Vincent Fehmer, Irena Sailer

Objectives

The objective of this study is to investigate the outcomes of clinically relevant laboratory studies regarding the cementation of implant-supported restorations over ti-bases.

Materials and Methods

The present study has been conducted according to PRISMA statement. An electronic search was performed, including publications up to March 2024, to identify studies investigating the parameters affecting the cementation between ti-bases and CAD/CAM prostheses. An assessment of the internal validity was performed, using a custom-made risk of bias tool (QUIN).

Results

From the included studies, 40.1% were reported on luting systems, 25% on ti-base surface treatment, 25% on restoration surface, 21.8% on restoration material, and 18.7% on ti-base height. The majority of the included studies were associated with a medium risk of bias. In the absence of micro-retentive features, air-abrasion of ti-bases with a minimum height of 3.5 mm can be beneficial for restoration's retention. The bonding performance can vary not only between different bonding systems but also for different applications within the same system, based on a restoration's material and surface treatment as well as on ti-base height and surface treatment.

Conclusions

The height of the ti-base seems to be the prevailing factor as it constitutes the prerequisite for other modifications of the bonding surfaces to have an advantageous effect. Since the parameters that can affect bonding performance between ti-base and restoration can interact with each other, it is important for the clinician to focus on verified bonding protocols.

研究目的本研究的目的是调查与临床相关的实验室研究结果，了解种植体支持的修复体在钛基底上的粘结情况：本研究根据 PRISMA 声明进行。本研究根据 PRISMA 声明进行，对截至 2024 年 3 月的出版物进行了电子检索，以确定对影响 ti 基底与 CAD/CAM 修复体之间固结的参数进行调查的研究。使用定制的偏倚风险工具（QUIN）对内部有效性进行了评估：结果：在纳入的研究中，40.1%的研究涉及洗脱系统，25%的研究涉及ti基底表面处理，25%的研究涉及修复体表面，21.8%的研究涉及修复体材料，18.7%的研究涉及ti基底高度。大部分纳入研究的偏倚风险为中等。在没有微固位功能的情况下，对最小高度为 3.5 毫米的牙基底进行气磨可有利于修复体的固位。根据修复体的材料和表面处理以及牙基高度和表面处理，不仅不同粘接系统的粘接性能会有所不同，而且同一系统内的不同应用也会有所不同：粘接基底的高度似乎是主要因素，因为它是粘接表面的其他改良产生有利效果的先决条件。由于影响基底和修复体之间粘接性能的参数会相互影响，因此临床医生必须关注经过验证的粘接方案。

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引用次数: 0

Survival and complication rates of tooth- and implant-supported restorations after an observation period up to 36 years 经过长达 36 年的观察，牙齿和种植体支撑修复体的存活率和并发症发生率。

IF 4.8 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical Oral Implants Research

Pub Date : 2024-08-23 DOI: 10.1111/clr.14351

Frank M. Bischof, Ayse A. Mathey, Alexandra Stähli, Giovanni E. Salvi, Urs Brägger

Background

Tooth- and implant-supported fixed dental prostheses are well-documented and aesthetic treatment alternatives, and after a comprehensive periodontal treatment, a protocol with a good long-term prognosis if the maintenance program is strictly followed.

Aim

To reexamine a pre-existing patient cohort in order to obtain estimated long-term survival and complication outcomes of fixed dental prostheses.

Materials and Methods

For this study, patients treated with fixed dental prostheses between 1978 and 2002 were reexamined between 2019 and 2020. The restorations were divided in single crowns and fixed dental prostheses supported by teeth (TSC, FPTDP) and implants (ISC, FPIDP). Survival and complication rates were obtained. Kaplan–Meier functions were used to model complication probabilities, and average hazard ratios of different strata were compared using weighted Cox regression.

Results

The mean observation time of 40 patients and 223 reconstructions was 20.3 (±9.7, 1.2–36.2) years. The estimated survival rates were 84% (CI: 77%–92%) for TSC, 63% (CI: 51%–79%) for FPTDP, 87% (CI: 71%–100%) for ISC, and 64% (CI: 34%–100%) for FPIDP after 25 years. Biological complications included carious lesions (10.6%), periodontitis (7.9%), and peri-implantitis (6.8%). Technical complications included chipping (20.2%) and loss of retention (10.8%).

Conclusion

Biological complications lead to abutment loss in more than two-thirds of cases, regardless of the type of abutment (tooth or implant). Technical complications are less associated with abutment loss than biological complications.

背景：牙和种植体支持的固定义齿是有充分证据证明的美观的治疗选择，在经过全面的牙周治疗后，如果严格遵守维护计划，长期预后良好。目的：重新审查先前存在的患者队列，以获得固定义齿的估计长期存活率和并发症结果：本研究在2019年至2020年期间对1978年至2002年期间接受过固定义齿治疗的患者进行了复查。修复体分为单冠和由牙齿（TSC、FPTDP）和种植体（ISC、FPIDP）支持的固定义齿。获得了存活率和并发症发生率。使用 Kaplan-Meier 函数建立并发症概率模型，并使用加权 Cox 回归比较不同分层的平均危险比：结果：40名患者和223次重建的平均观察时间为20.3（±9.7，1.2-36.2）年。25年后，TSC的估计存活率为84%（CI：77%-92%），FPTDP为63%（CI：51%-79%），ISC为87%（CI：71%-100%），FPIDP为64%（CI：34%-100%）。生物并发症包括龋齿（10.6%）、牙周炎（7.9%）和种植体周围炎（6.8%）。技术并发症包括崩裂（20.2%）和固位丧失（10.8%）：结论：生物并发症导致三分之二以上的病例基台脱落，无论基台类型（牙齿或种植体）如何。与生物并发症相比，技术并发症与基台缺失的关系较小。

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引用次数: 0

Complication, vertical bone gain, volumetric changes after vertical ridge augmentation using customized reinforced PTFE mesh or Ti-mesh. A non-inferiority randomized clinical trial 使用定制强化聚四氟乙烯网或钛网进行垂直脊增量术后的并发症、垂直骨增量和体积变化。非劣效性随机临床试验。

IF 4.8 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical Oral Implants Research

Pub Date : 2024-08-23 DOI: 10.1111/clr.14350

Alessandro Cucchi, Sofia Bettini, Lucia Tedeschi, Istvan Urban, Debora Franceschi, Antonino Fiorino, Giuseppe Corinaldesi

Objective

The aim of this non-inferiority randomized clinical trial was to compare the surgical and healing complications, vertical bone gain, and volumetric bone changes after vertical ridge augmentation using two different approaches: customized Ti-reinforced d-PTFE mesh versus customized CAD/CAM Ti-mesh.

Materials and Methods

Fifty patients with vertical bone defects were randomly treated with Ti-reinforced d-PTFE mesh (control group) or CAD/CAM Ti-mesh (test group) and a mix of autogenous bone and deproteinized bovine bone matrix. Surgical and healing complication rates (SCR-HCR), vertical bone gain (VBG), regenerated bone volume (RBV), and regeneration rates (RR and ERR) were recorded and analysed [significance level (α) of 0.05].

Results

Of the 50 patients, 48 underwent bone augmentation surgery. SCR were 4% and 12% in PTFE and Ti-mesh, whereas HCR were 12.5% and 8.3%. VBG were 5.79 ± 1.71 mm (range: 3.2–8.8 mm) in the PTFE group and 5.18 ± 1.61 mm (range: 3.1–8.0 mm) in the Ti-mesh group (p = .233), whereas RBV were 1.46 ± 0.48 cc and 1.26 ± 0.55. RR was 99.5% and 87.0%, demonstrating a statistically significant difference (p = .013). Finally, the values related to pseudo-periosteum, bone density, and implant stability were similar in the two study groups. Osseointegration rates were 98.2% and 98.3%.

Conclusions

This study confirmed the non-inferiority of customized CAD/CAM titanium meshes with respect to reinforced PTFE meshes in terms of surgical and healing complications. Although PTFE meshes showed higher vertical bone gain and regeneration rates than Ti-meshes, no significant differences were found.

目的这项非劣效性随机临床试验旨在比较使用两种不同方法（定制的 Ti-reinforced d-PTFE 网片和定制的 CAD/CAM Ti-mesh）进行垂直骨嵴增量术后的手术和愈合并发症、垂直骨增量和骨体积变化：50名垂直骨缺损患者随机接受了钛增强d-PTFE网（对照组）或CAD/CAM钛网（试验组）以及自体骨和去蛋白牛骨基质的混合治疗。记录并分析了手术和愈合并发症发生率（SCR-HCR）、垂直骨增量（VBG）、再生骨量（RBV）和再生率（RR 和 ERR）[显著性水平（α）为 0.05]：结果：50 名患者中有 48 人接受了骨质增生手术。聚四氟乙烯和钛网的SCR分别为4%和12%，而HCR分别为12.5%和8.3%。PTFE 组的 VBG 为 5.79 ± 1.71 mm（范围：3.2-8.8 mm），Ti-mesh 组为 5.18 ± 1.61 mm（范围：3.1-8.0 mm）（p = .233），而 RBV 分别为 1.46 ± 0.48 cc 和 1.26 ± 0.55。RR分别为99.5%和87.0%，差异具有统计学意义（p = .013）。最后，假骨膜、骨密度和种植体稳定性的相关数值在两组研究中相似。骨结合率分别为98.2%和98.3%：这项研究证实，在手术和愈合并发症方面，CAD/CAM 定制钛网与增强聚四氟乙烯网相比并无劣势。虽然聚四氟乙烯网片比钛网片显示出更高的垂直骨增量和再生率，但并未发现显著差异。

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引用次数: 0

A 7.5-year randomized controlled clinical study comparing cemented and screw-retained one-piece zirconia-based implant-supported single crowns 一项为期 7.5 年的随机对照临床研究，比较了粘结型和螺钉固位型一体式氧化锆种植体支撑单冠。

IF 4.8 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical Oral Implants Research

Pub Date : 2024-08-22 DOI: 10.1111/clr.14346

Riccardo D. Kraus, Jenni Hjerppe, Nadja Naenni, Marc Balmer, Ronald E. Jung, Daniel S. Thoma

Objectives

To compare marginal bone levels, biological, and technical outcomes of screw-retained versus cemented all-ceramic implant-supported zirconia-based single crowns after an observation period of 7.5 years.

Methods

Forty-four single implants in the esthetic zone in 44 patients (22 females, 22 males) were randomly assigned to two types of restorations: SR (screw-retained); veneered one-piece zirconia abutment and CR (cement-retained); veneered lithium disilicate crown intraorally cemented on a one-piece zirconia abutment. Patients were recalled annually up to 7.5 years and survival rates, biological, and technical parameters assessed.

Results

A total of 31 patients attended the 7.5-year follow-up visit (17 SR group, 14 CR group). The survival rate on the restorative level was 77.5% (74.0% CR, 81.0% SR, p = .6399). Median marginal bone loss (MBL) values yielded −0.073 mm (−0.305; 0.238) in the CR and −0.215 mm (−0.500; 0.555) in the SR group (intergroup p = .6194). Mean bleeding on probing (BoP) values were significantly in favor of group SR with 20 ± 17% compared to 40 ± 22% in group CR (p = .011). The overall biological complication rate amounted to 27.5% (42.1% CR, 14.3% SR, p = .0775), whereas the technical complication rate was 32.5% (42.1% CR, 23.8% SR, p = .314). In total, CR restorations showed significantly more complications (84.2% for CR, 38.1% for SR, p = .0041).

Conclusion

One-piece zirconia-based single crowns on two-piece dental implants exhibited a high rate of technical and biological complications at 7.5 years of follow-up. Cemented restorations revealed significant higher rates of bleeding on probing and total complications compared to screw-retained restorations.

目的观察 7.5 年后，比较螺钉固位与粘结全瓷种植体支持氧化锆单冠的边缘骨水平、生物学和技术效果：44名患者（22名女性，22名男性）的44颗种植体被随机分配到两种修复体中：SR（螺钉固位）；饰面一体氧化锆基台和 CR（骨水泥固位）；饰面二硅酸锂冠口内粘接一体氧化锆基台。每年对患者进行回访，直至 7.5 年，并对患者的存活率、生物学和技术参数进行评估：共有 31 名患者参加了 7.5 年的随访（SR 组 17 人，CR 组 14 人）。修复体的存活率为 77.5%（74.0% CR，81.0% SR，p = .6399）。CR组边缘骨损失（MBL）中值为-0.073 mm (-0.305; 0.238)，SR组为-0.215 mm (-0.500; 0.555)（组间 p = .6194）。探诊出血（BoP）的平均值为 20 ± 17%，SR 组明显高于 CR 组的 40 ± 22%（p = .011）。总体生物并发症发生率为 27.5%（42.1% CR，14.3% SR，p = .0775），而技术并发症发生率为 32.5%（42.1% CR，23.8% SR，p = .314）。总的来说，CR修复体的并发症明显较多（CR为84.2%，SR为38.1%，p = .0041）：结论：两件式种植体上的氧化锆单冠在7.5年的随访中显示出较高的技术和生物学并发症发生率。与螺钉固位修复体相比，粘结修复体的探诊出血率和总并发症发生率明显更高。

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引用次数: 0

Alveolar ridge preservation in posterior maxillary teeth for reduction in the potential need for sinus floor elevation procedures: A pilot study 保留上颌后牙的牙槽嵴以减少窦底抬高手术的潜在需求：试点研究。

IF 4.8 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical Oral Implants Research

Pub Date : 2024-08-21 DOI: 10.1111/clr.14344

Lisetta Lam, Saso Ivanovski, Ryan S. B. Lee

Objectives

To investigate the effects of alveolar ridge preservation (ARP) on ridge height, sinus pneumatization and the potential need for lateral sinus augmentation following extraction in the posterior maxilla.

Materials and Methods

This randomized controlled pilot study included 28 patients requiring extraction in the posterior maxilla with bone height between 6 and 8 mm. The sites were randomly allocated to either unassisted socket healing (Control), ARP with deproteinized bovine bone mineral (DBBM) (Test 1), or collagen-stabilized DBBM (Test 2) groups. Pre- and post-operative CTs at 4 months were taken to determine changes in ridge heights, sinus volume, and the need for sinus floor elevation (SFE) procedures for cases where the residual mid-ridge height was < 5 mm. Site-level analyses for changes in vertical ridge dimensions and sinus volume pre- and post-extraction/ARP were conducted using paired t-tests. Differences in mean changes in vertical ridge dimensions and sinus volume between the groups were determined using one-way ANOVA.

Results

Significantly greater mean mid-ridge height reduction occurred in the control group (−2.7 ± 0.9 mm) compared to Test 1 (0.9 ± 3.7 mm) and Test 2 (1.0 ± 2.8 mm) groups (p < .05). No significant changes in mean mid-ridge height were found in either test groups. Volumetric analysis showed a significantly greater increase in sinus volume in the control group (0.7 ± 0.7 cm³) compared to Test 1 (n = 3, −0.7 ± 0.8 cm³) group (p = .03). 89% of patients in the control group would require lateral window SFE compared to Test 1 (42.8%) and Test 2 (40%) groups.

Conclusion

ARP was effective in attenuating height changes in the middle of the ridge and may reduce sinus pneumatization following extraction in the posterior maxilla. This could potentially decrease the need for more invasive sinus augmentation procedures.

目的研究牙槽嵴保留（ARP）对牙槽嵴高度、上颌窦气化以及上颌后牙拔除后侧窦增量的潜在需求的影响：这项随机对照试验研究包括 28 名需要在上颌后部拔牙的患者，他们的骨高度在 6 至 8 毫米之间。这些患者被随机分配到无辅助牙槽骨愈合组（对照组）、含去蛋白牛骨矿物质（DBBM）的 ARP 组（试验 1）或胶原稳定的 DBBM 组（试验 2）。术前和术后 4 个月时进行 CT 检查，以确定牙脊高度、窦容积的变化，以及残余中脊高度小于 5 毫米的病例是否需要进行窦底抬高 (SFE) 手术。采用配对 t 检验对拔牙/ARP 前后垂直牙脊尺寸和上颌窦容积的变化进行现场分析。采用单因素方差分析确定组间垂直嵴尺寸和窦容积平均变化的差异：结果：对照组（-2.7 ± 0.9 mm）与试验 1 组（0.9 ± 3.7 mm）和试验 2 组（1.0 ± 2.8 mm）（p 3）相比，试验 1 组（n = 3，-0.7 ± 0.8 cm3）的中脊高度平均降低幅度明显更大（p = .03）。与测试 1 组（42.8%）和测试 2 组（40%）相比，对照组 89% 的患者需要侧窗 SFE：结论：ARP 能有效减轻牙脊中部的高度变化，并能减少上颌后牙拔除后的窦积气。这可能会减少对更具创伤性的上颌窦增量手术的需求。

{"title":"Alveolar ridge preservation in posterior maxillary teeth for reduction in the potential need for sinus floor elevation procedures: A pilot study","authors":"Lisetta Lam, Saso Ivanovski, Ryan S. B. Lee","doi":"10.1111/clr.14344","DOIUrl":"10.1111/clr.14344","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To investigate the effects of alveolar ridge preservation (ARP) on ridge height, sinus pneumatization and the potential need for lateral sinus augmentation following extraction in the posterior maxilla.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>This randomized controlled pilot study included 28 patients requiring extraction in the posterior maxilla with bone height between 6 and 8 mm. The sites were randomly allocated to either unassisted socket healing (Control), ARP with deproteinized bovine bone mineral (DBBM) (Test 1), or collagen-stabilized DBBM (Test 2) groups. Pre- and post-operative CTs at 4 months were taken to determine changes in ridge heights, sinus volume, and the need for sinus floor elevation (SFE) procedures for cases where the residual mid-ridge height was < 5 mm. Site-level analyses for changes in vertical ridge dimensions and sinus volume pre- and post-extraction/ARP were conducted using paired <i>t</i>-tests. Differences in mean changes in vertical ridge dimensions and sinus volume between the groups were determined using one-way ANOVA.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Significantly greater mean mid-ridge height reduction occurred in the control group (−2.7 ± 0.9 mm) compared to Test 1 (0.9 ± 3.7 mm) and Test 2 (1.0 ± 2.8 mm) groups (<i>p</i> < .05). No significant changes in mean mid-ridge height were found in either test groups. Volumetric analysis showed a significantly greater increase in sinus volume in the control group (0.7 ± 0.7 cm<sup>3</sup>) compared to Test 1 (<i>n</i> = 3, −0.7 ± 0.8 cm<sup>3</sup>) group (<i>p</i> = .03). 89% of patients in the control group would require lateral window SFE compared to Test 1 (42.8%) and Test 2 (40%) groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>ARP was effective in attenuating height changes in the middle of the ridge and may reduce sinus pneumatization following extraction in the posterior maxilla. This could potentially decrease the need for more invasive sinus augmentation procedures.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"35 12","pages":"1568-1584"},"PeriodicalIF":4.8,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11629457/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142008404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Higher solubility and lower onset temperature of protein denaturation increase the osteoconductive capacity of collagen membranes: A preclinical in vivo study 更高的溶解度和更低的蛋白质变性起始温度可提高胶原蛋白膜的骨诱导能力：临床前体内研究。

IF 4.8 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical Oral Implants Research

Pub Date : 2024-08-21 DOI: 10.1111/clr.14345

Zahra Sadat-Marashi, Masako Fujioka-Kobayashi, Hiroki Katagiri, Niklaus P. Lang, Nikola Saulacic

Objectives

Collagen membranes are extensively used for guided bone regeneration procedures, primarily for horizontal bone augmentation. More recently, it has been demonstrated that collagen membranes promote bone regeneration. Present study aimed at assessing if structural modifications of collagen membranes may enhance their osteoconductive capacity.

Methods

Twenty-four adult Wistar rats were used. Bilateral calvaria defects with a diameter of 5 mm were prepared and covered with prototypes of collagen membranes (P1 or P2). The P1 membrane (positive control) presented a lower onset temperature of protein denaturation and a higher solubility than the P2 membrane (test). The contralateral defects were left uncovered (NC). After 1 and 4 weeks, the animals were euthanized. A microcomputed tomography analysis of the harvested samples was performed within and above the bony defect. Undecalcified ground sections were subjected to light microscopy and morphometric analysis.

Results

Bone formation was observed starting from the circumferential borders of the defects in all groups at 1-week of healing. The foci of ossification were observed at the periosteal and dura mater sites, with signs of collagen membrane mineralization. However, there was no statistically significant difference between the groups. At 4 weeks, remnants of the collagen fibers were embedded in the newly formed bone. In the P2 group, significantly more bone volume, more new bone, and marrow spaces compared to the NC group were observed. Furthermore, the P2 group showed more bone volume ectocranially then the P1 group.

Conclusions

Bone formation subjacent to a P2 membrane was superior than subjacent to the P1 membrane and significantly better compared to the control. Modifications of the physico-chemical properties may enhance the osteoconductive competence of collagen membranes, supporting bone formation outside the bony defects.

目的：胶原蛋白膜被广泛用于引导性骨再生手术，主要用于水平骨增量。最近的研究表明，胶原蛋白膜可促进骨再生。本研究旨在评估胶原蛋白膜的结构修饰是否能增强其骨诱导能力：方法：使用 24 只成年 Wistar 大鼠。方法：用 24 只成年 Wistar 大鼠制备直径为 5 毫米的双侧腓肠肌缺损，并用胶原蛋白膜原型（P1 或 P2）覆盖。与 P2 膜（试验）相比，P1 膜（阳性对照）的蛋白质变性起始温度更低，溶解度更高。对侧缺损不作任何处理（NC）。1 周和 4 周后，动物被安乐死。在骨缺损内和骨缺损上方对采集的样本进行微计算机断层扫描分析。对未钙化的地面切片进行光学显微镜检查和形态计量分析：结果：愈合 1 周时，所有组别均可观察到从缺损周缘开始的骨形成。骨化灶位于骨膜和硬脑膜部位，并伴有胶原膜矿化的迹象。不过，各组之间没有统计学意义上的显著差异。4 周时，胶原纤维的残余嵌入新形成的骨中。与 NC 组相比，P2 组的骨量、新骨量和骨髓间隙明显增加。此外，P2 组比 P1 组显示出更多的颅外骨量：结论：P2 膜下的骨形成优于 P1 膜下，且明显优于对照组。物理化学性质的改变可增强胶原蛋白膜的骨诱导能力，支持骨缺损外的骨形成。

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引用次数: 0

Four-mm-short implants in the rehabilitation of posterior atrophic jaws: A retrospective study on 212 patients with a mean follow-up of 8.02 years 后萎缩颌骨修复中的四毫米短种植体：对 212 名患者进行的一项回顾性研究，平均随访时间为 8.02 年。

IF 4.8 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical Oral Implants Research

Pub Date : 2024-08-20 DOI: 10.1111/clr.14349

Carlo Barausse, Roberto Pistilli, Lorenzo Bonifazi, Subhi Tayeb, Gerardo Pellegrino, Andrea Ravidà, Pietro Felice

Objective

This study aimed to assess clinical efficacy of 4-mm-short implants in patients with posterior severe vertical bone atrophy in the medium- and long-term follow-up.

Materials and Methods

Patients rehabilitated with 4-mm-short implants in the posterior atrophic jaws, with a minimum follow-up of 3 years post-loading, were included in the study. Data were collected for eligible patients, and marginal bone loss (MBL) for each implant was evaluated. The research outcomes were implant failure, MBL and complications.

Results

A total of 212 patients with 496 implants were included, resulting in a mean follow-up of 8.02 ± 2.17 years. The implant survival rate was 95.36% (95% CI: 93.12%–97.04%). More implant failures were observed in the maxilla (p = .02) and fewer failures were observed in patients undergoing more number of hygienic sessions per year (p < .001). The average MBL after 1-year-loading was 0.47 mm, increasing to 0.59 mm after 10 years; after 3 years no statistically significant increase in MBL was observed. Maxillary implants showed greater bone loss than mandibular ones (p < .001). More frequent professional oral hygiene sessions per year resulted being related with reduced MBL (p < .001).

Conclusions

Four-mm-short implants showed high survival rates with an up to 10-year follow-up. Their use can offer a fixed prosthetic solution for patients with posterior vertical bone atrophy, minimizing surgical invasiveness, rehabilitative times and costs.

目的本研究旨在评估4毫米短种植体在后部严重垂直骨萎缩患者的中长期随访中的临床疗效：研究对象包括在后部萎缩颌骨中使用 4 毫米短种植体进行修复的患者，这些患者在植入种植体后至少随访 3 年。研究人员收集了符合条件的患者数据，并对每个种植体的边缘骨质流失（MBL）进行了评估。研究结果包括种植失败、骨质疏松和并发症：共纳入 212 名患者，496 个种植体，平均随访时间为 8.02±2.17 年。种植体存活率为 95.36%（95% CI：93.12%-97.04%）。在上颌观察到更多的种植体失败（p = .02），在每年接受更多卫生治疗的患者中观察到更少的种植体失败（p 结论：在上颌观察到更多的种植体失败（p = .03），在每年接受更多卫生治疗的患者中观察到更少的种植体失败（p = .04）：四毫米短种植体在长达 10 年的随访中显示出较高的存活率。它们可以为后部垂直骨质萎缩的患者提供固定假体解决方案，最大限度地减少手术创伤、康复时间和费用。

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引用次数: 0