Philipp Kauffmann, Susanne Wolfer, Christina Behrens, Pauline Schlosser, Christian Dullin, Uwe Schirmer, Klaus Liefeith, Henning Schliephake
Objectives
The aim of the present study was to assess the effect of dual growth factor release from collagen-based polyelectrolyte multilayer films (PEMs) on titanium implants on periimplant bone formation and angiogenetic activity in minipig mandibles.
Material and Methods
Disc shaped Ti implants (5 × 7 × 1 mm) were coated with polyelectrolyte multilayer films and loaded with rhBMP-2, rhVEGF165, and a combination of both. Uncoated and unloaded Ti implants served as controls. The implants were inserted press-fit into 5 mm trephine cavities in minipig mandibles and evaluated after 4 and 13 weeks for bone formation, bone implant contact, and periimplant expression of CD31.
Results
After 4 weeks, there was no significant difference in periimplant bone formation nor bone-implant contact between the different surface conditions. CD31 expression was significantly increased around PEM coated implants loaded with VEGF and BMP each. After 13 weeks, bone implant contact and bone formation were significantly increased only around PEM coated implants with simultaneous release of BMP-2 and VEGF165. Expression of CD31 was significantly enhanced around all PEM coated implants loaded with growth factors regardless of the type or combination.
Conclusion
It is concluded that simultaneous release of rhBMP-2 and rhVEGF165 may be required to achieve significant improvement of periimplant bone formation and bone implant contact. Angiogenesis as reflected by CD31 expression is enhanced by both rhVEGF165 and rhBMP-2 to a similar extent without an additive effect of simultaneous release.
{"title":"Dual Growth Factor Release From Collagen Based Multilayer Films on Ti-Surfaces Enhances Periimplant Bone Formation and Angiogenic Activity—An Experimental In-Vivo Study","authors":"Philipp Kauffmann, Susanne Wolfer, Christina Behrens, Pauline Schlosser, Christian Dullin, Uwe Schirmer, Klaus Liefeith, Henning Schliephake","doi":"10.1111/clr.70045","DOIUrl":"10.1111/clr.70045","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The aim of the present study was to assess the effect of dual growth factor release from collagen-based polyelectrolyte multilayer films (PEMs) on titanium implants on periimplant bone formation and angiogenetic activity in minipig mandibles.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>Disc shaped Ti implants (5 × 7 × 1 mm) were coated with polyelectrolyte multilayer films and loaded with rhBMP-2, rhVEGF165, and a combination of both. Uncoated and unloaded Ti implants served as controls. The implants were inserted press-fit into 5 mm trephine cavities in minipig mandibles and evaluated after 4 and 13 weeks for bone formation, bone implant contact, and periimplant expression of CD31.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>After 4 weeks, there was no significant difference in periimplant bone formation nor bone-implant contact between the different surface conditions. CD31 expression was significantly increased around PEM coated implants loaded with VEGF and BMP each. After 13 weeks, bone implant contact and bone formation were significantly increased only around PEM coated implants with simultaneous release of BMP-2 and VEGF165. Expression of CD31 was significantly enhanced around all PEM coated implants loaded with growth factors regardless of the type or combination.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>It is concluded that simultaneous release of rhBMP-2 and rhVEGF165 may be required to achieve significant improvement of periimplant bone formation and bone implant contact. Angiogenesis as reflected by CD31 expression is enhanced by both rhVEGF165 and rhBMP-2 to a similar extent without an additive effect of simultaneous release.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"37 1","pages":"1-17"},"PeriodicalIF":5.3,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/clr.70045","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145035997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
To evaluate a novel protocol for vertical ridge augmentation with titanium-(Ti)-reinforced dual-texture expanded polytetrafluoroethylene (e-PTFE) membranes, 100% autogenous bone, and 12 months of bone healing in the anterior maxilla.
Material and Methods
This retrospective study included 14 consecutive patients treated between 2016 and 2021. Large defects, including both vertical and horizontal components, were treated with autogenous bone grafting and non-resorbable Ti-reinforced dual-texture e-PTFE membranes. Implants were placed in the augmented bone after 12 months. All clinical and radiographical parameters were retrieved from patient records.
Results
The case series included 14 patients treated with 15 e-PTFE membranes. The mean initial vertical defect size was 7.5 ± 5.1 mm (range: 3–23 mm). All membranes remained unexposed during the entire healing period (12.6 ± 1.2 months). No complications that needed intervention occurred. Complete bone fill was achieved, that is, regenerated bone filled the entire volume created by the membrane, in all treated defects. Twenty-three implants were placed. The survival rate was 100% and the mean marginal bone level was 0.08 ± 0.11 mm after up to 5 years.
Conclusions
Excellent vertical augmentation outcomes can be achieved in the anterior maxilla using a non-resorbable Ti-reinforced e-PTFE membrane and an autogenous bone graft, followed by 12 months of healing before implant placement. The implants demonstrated stable marginal bone levels after loading. This case series has limitations, mainly the retrospective nature and small sample size, but it indicates that the proper choice of methods, materials, and healing times during GBR results in a predictable clinical outcome.
{"title":"Vertical Ridge Augmentation in the Anterior Maxilla Using a Dual-Texture e-PTFE Membrane and Autogenous Bone: A 2- to 5-Year Retrospective Case-Series Study","authors":"David González, Herman Sahlin, Christer Dahlin","doi":"10.1111/clr.70044","DOIUrl":"10.1111/clr.70044","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To evaluate a novel protocol for vertical ridge augmentation with titanium-(Ti)-reinforced dual-texture expanded polytetrafluoroethylene (e-PTFE) membranes, 100% autogenous bone, and 12 months of bone healing in the anterior maxilla.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>This retrospective study included 14 consecutive patients treated between 2016 and 2021. Large defects, including both vertical and horizontal components, were treated with autogenous bone grafting and non-resorbable Ti-reinforced dual-texture e-PTFE membranes. Implants were placed in the augmented bone after 12 months. All clinical and radiographical parameters were retrieved from patient records.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The case series included 14 patients treated with 15 e-PTFE membranes. The mean initial vertical defect size was 7.5 ± 5.1 mm (range: 3–23 mm). All membranes remained unexposed during the entire healing period (12.6 ± 1.2 months). No complications that needed intervention occurred. Complete bone fill was achieved, that is, regenerated bone filled the entire volume created by the membrane, in all treated defects. Twenty-three implants were placed. The survival rate was 100% and the mean marginal bone level was 0.08 ± 0.11 mm after up to 5 years.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Excellent vertical augmentation outcomes can be achieved in the anterior maxilla using a non-resorbable Ti-reinforced e-PTFE membrane and an autogenous bone graft, followed by 12 months of healing before implant placement. The implants demonstrated stable marginal bone levels after loading. This case series has limitations, mainly the retrospective nature and small sample size, but it indicates that the proper choice of methods, materials, and healing times during GBR results in a predictable clinical outcome.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"36 12","pages":"1664-1674"},"PeriodicalIF":5.3,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/clr.70044","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145035240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The cover 3 image is based on the article Bi-Layered Biphasic Calcium Phosphate Bone Substitute to Improve Bone Formation in Lateral Jaw Defects Applying the Principle of Guided Bone Regeneration (GBR)—A Pre-Clinical Randomized Controlled Study by Kiri N. Lang et al., https://doi.org/10.1111/clr.14460.
封面3的图片是基于Kiri N. Lang等人的文章《应用引导骨再生（GBR）原理改善侧颌缺损骨形成的双层双相钙磷酸盐骨替代物——临床前随机对照研究https://doi.org/10.1111/clr.14460》。
{"title":"Additional Cover","authors":"","doi":"10.1111/clr.70043","DOIUrl":"10.1111/clr.70043","url":null,"abstract":"<p>The cover 3 image is based on the article <i>Bi-Layered Biphasic Calcium Phosphate Bone Substitute to Improve Bone Formation in Lateral Jaw Defects Applying the Principle of Guided Bone Regeneration (GBR)—A Pre-Clinical Randomized Controlled Study</i> by Kiri N. Lang et al., https://doi.org/10.1111/clr.14460. \u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"36 9","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/clr.70043","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145035133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The cover 2 image is based on the article Ridge Preservation in Extraction Sockets of Periodontally Compromised Molars With and Without Primary Wound Closure: Histological and 1-Year Implant Outcomes of a Clinical Trial by Yiping Wei et al., https://doi.org/10.1111/clr.14459.
{"title":"Additional Cover","authors":"","doi":"10.1111/clr.70042","DOIUrl":"10.1111/clr.70042","url":null,"abstract":"<p>The cover 2 image is based on the article <i>Ridge Preservation in Extraction Sockets of Periodontally Compromised Molars With and Without Primary Wound Closure: Histological and 1-Year Implant Outcomes of a Clinical Trial</i> by Yiping Wei et al., https://doi.org/10.1111/clr.14459. \u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"36 9","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/clr.70042","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145035132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alberto Monje, Ramon Pons, Maria Costanza Soldini, Paul S. Rosen, José Nart, Daniel Buser
Objective
A cross-sectional study was made to evaluate the role of local factors, including surgical, implant, and prosthesis-related parameters, in the presence of peri-implantitis.
Methods
Consecutive partially edentulous patients with ≥ 1 implant presenting peri-implantitis were included. Clinical and radiographic data were collected to characterize local factors. Overall, 28 site-specific variables were analyzed for peri-implantitis and non-peri-implantitis implants. Simple and multiple logistic regression analyses were performed to explore potential associations. The diagnostic accuracy of those variables that demonstrated statistical significance in the multiple logistic regression analysis was further tested.
Results
In total, 100 patients with 452 implants met the inclusion criteria. Of these, 227 implants (50.2%) were diagnosed with peri-implantitis, while 225 (49.8%) did not present peri-implantitis. The multiple logistic regression analysis demonstrated statistical significance for the following factors: (1) medial implant position within the prosthesis (OR = 3.9) was more prone to develop peri-implantitis; (2) internal Morse taper implant connection was the least likely to develop peri-implantitis (OR = 0.43); (3) mesio-distally centered implants were less prone to exhibit peri-implantitis (OR = 0.46); (4) bucco-lingual centered implants were less prone to exhibit peri-implantitis (OR = 0.29); (5) implants positioned inside (≥ 2 mm) the bony housing were less prone to exhibit peri-implantitis (OR = 0.13); and (6) implants tilted 10°–30° (OR = 5.84) and ≥ 30° (OR = 7.43) were more prone to exhibit peri-implantitis. Moreover, a prediction model based on the aforementioned factors yielded a high level of accuracy.
Conclusions
Implant malpositioning is a critical factor associated with peri-implantitis.
{"title":"Role of Local Factors on the Occurrence of Peri-Implantitis: A Cross-Sectional Analysis","authors":"Alberto Monje, Ramon Pons, Maria Costanza Soldini, Paul S. Rosen, José Nart, Daniel Buser","doi":"10.1111/clr.70036","DOIUrl":"10.1111/clr.70036","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>A cross-sectional study was made to evaluate the role of local factors, including surgical, implant, and prosthesis-related parameters, in the presence of peri-implantitis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Consecutive partially edentulous patients with ≥ 1 implant presenting peri-implantitis were included. Clinical and radiographic data were collected to characterize local factors. Overall, 28 site-specific variables were analyzed for peri-implantitis and non-peri-implantitis implants. Simple and multiple logistic regression analyses were performed to explore potential associations. The diagnostic accuracy of those variables that demonstrated statistical significance in the multiple logistic regression analysis was further tested.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In total, 100 patients with 452 implants met the inclusion criteria. Of these, 227 implants (50.2%) were diagnosed with peri-implantitis, while 225 (49.8%) did not present peri-implantitis. The multiple logistic regression analysis demonstrated statistical significance for the following factors: (1) medial implant position within the prosthesis (OR = 3.9) was more prone to develop peri-implantitis; (2) internal Morse taper implant connection was the least likely to develop peri-implantitis (OR = 0.43); (3) mesio-distally centered implants were less prone to exhibit peri-implantitis (OR = 0.46); (4) bucco-lingual centered implants were less prone to exhibit peri-implantitis (OR = 0.29); (5) implants positioned inside (≥ 2 mm) the bony housing were less prone to exhibit peri-implantitis (OR = 0.13); and (6) implants tilted 10°–30° (OR = 5.84) and ≥ 30° (OR = 7.43) were more prone to exhibit peri-implantitis. Moreover, a prediction model based on the aforementioned factors yielded a high level of accuracy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Implant malpositioning is a critical factor associated with peri-implantitis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"36 12","pages":"1614-1625"},"PeriodicalIF":5.3,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/clr.70036","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cláudio Mendes Pannuti, Hélio Doyle Pereira da Silva, Naichuan Su, Kar Yan Li, Lisa J. A. Heitz-Mayfield
Objective
Statistics is fundamental in implant dentistry research, playing a crucial role in study design, data analysis, and interpretation of findings. This editorial, authored by members of the Statistical Advisory Board of Clinical Oral Implants Research, aims to highlight common statistical pitfalls encountered in submitted manuscripts and provide practical recommendations to enhance the quality of statistical reporting.
Materials and Methods
In this editorial, study design considerations, sample size calculation, appropriate selection of statistical tests, multiplicity issues, handling hierarchical data structures, and best practices for data presentation are discussed. The importance of pre-registering research protocols, adhering to pre-specified analyses, and reporting effect sizes alongside p-values is emphasised. Additionally, common misinterpretations of statistical significance and the risks of extrapolating findings beyond their intended scope are addressed.
Results
Statistical errors remain prevalent in the scientific literature, affecting the validity of results and evidence-based decision making.
Conclusions
By following guidelines, authors can improve the robustness and reproducibility of their research, ultimately contributing to higher-quality evidence in implant dentistry. Guidance for researchers, reviewers, and readers in handling statistical challenges is presented aiming to ensure that studies published in Clinical Oral Implants Research meet the highest methodological standards.
{"title":"Statistical Gems and Cautions From the Statistical Advisory Board of Clinical Oral Implants Research","authors":"Cláudio Mendes Pannuti, Hélio Doyle Pereira da Silva, Naichuan Su, Kar Yan Li, Lisa J. A. Heitz-Mayfield","doi":"10.1111/clr.70033","DOIUrl":"10.1111/clr.70033","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Statistics is fundamental in implant dentistry research, playing a crucial role in study design, data analysis, and interpretation of findings. This editorial, authored by members of the Statistical Advisory Board of Clinical Oral Implants Research, aims to highlight common statistical pitfalls encountered in submitted manuscripts and provide practical recommendations to enhance the quality of statistical reporting.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>In this editorial, study design considerations, sample size calculation, appropriate selection of statistical tests, multiplicity issues, handling hierarchical data structures, and best practices for data presentation are discussed. The importance of pre-registering research protocols, adhering to pre-specified analyses, and reporting effect sizes alongside <i>p</i>-values is emphasised. Additionally, common misinterpretations of statistical significance and the risks of extrapolating findings beyond their intended scope are addressed<i>.</i></p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Statistical errors remain prevalent in the scientific literature, affecting the validity of results and evidence-based decision making.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>By following guidelines, authors can improve the robustness and reproducibility of their research, ultimately contributing to higher-quality evidence in implant dentistry. Guidance for researchers, reviewers, and readers in handling statistical challenges is presented aiming to ensure that studies published in Clinical Oral Implants Research meet the highest methodological standards.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"36 12","pages":"1525-1534"},"PeriodicalIF":5.3,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/clr.70033","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144995885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Natália dos Santos Sanches, Caroline Liberato Marchiolli, Lara Cristina Cunha Cervantes, Maria Cristina Ruiz Voms Stein, Sara Alves Berton, Estéfany Lopes Lemes do Prado, Carina Kampleitner, Francisley Ávila Souza, Roberta Okamoto, Reinhard Gruber, Idelmo Rangel Garcia Júnior
Introduction
Odanacatib (ODN), a cathepsin K inhibitor, is a drug that reduces bone resorption while preserving bone formation. ODN was initially developed for the treatment of postmenopausal osteoporosis, but further development as a systemic medication has been discontinued. Here, we propose ODN as a topical treatment, the coating of dental implants, to achieve an anabolic shift of early osseointegration.
Material and Methods
To this aim, we have coated double acid etching titanium implants (SLA) with and without ODN dispersed in a simulated body fluid (SBF). The implants were inserted into the tibia of 72 male Wistar rats and osseointegration was studied on Days 15 and 40. Biomechanical testing, micro-computed microtomography, and histomorphometric analyses were performed.
Results
Biomechanical testing reveals that after 15 days of healing, removal torque increased from 2.5 Ncm (1.5–4.4) to 3.9 Ncm (1.7–7.6) when comparing SBF alone with SBF containing ODN, respectively (p = 0.017). Consistently, micro-computed microtomography indicated that local bone volume increased from 24.4% (13.86–32.45) to 32.8% (19.7–39.4), respectively (p = 0.003). The same was true for presumed bone-to-implant contact, which was 34.38% (27.0–50.0) and 43.33% (31.6–54.2), respectively (p = 0.035). Histomorphometric analyses confirmed that the new bone area per total area increased from 34.78% (18.9–43.7) to 41.10% (23.5–54.0), respectively (p = 0.102). This trend proceeds after 40 days of osseointegration.
Discussion
These findings suggest that topical delivery of a cathepsin K inhibitor can support the early osseointegration phase in an ectopic rodent implantation model.
{"title":"Odanacatib Coating Supports Osseointegration of Implants: A Preclinical Study","authors":"Natália dos Santos Sanches, Caroline Liberato Marchiolli, Lara Cristina Cunha Cervantes, Maria Cristina Ruiz Voms Stein, Sara Alves Berton, Estéfany Lopes Lemes do Prado, Carina Kampleitner, Francisley Ávila Souza, Roberta Okamoto, Reinhard Gruber, Idelmo Rangel Garcia Júnior","doi":"10.1111/clr.70038","DOIUrl":"10.1111/clr.70038","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Odanacatib (ODN), a cathepsin K inhibitor, is a drug that reduces bone resorption while preserving bone formation. ODN was initially developed for the treatment of postmenopausal osteoporosis, but further development as a systemic medication has been discontinued. Here, we propose ODN as a topical treatment, the coating of dental implants, to achieve an anabolic shift of early osseointegration.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>To this aim, we have coated double acid etching titanium implants (SLA) with and without ODN dispersed in a simulated body fluid (SBF). The implants were inserted into the tibia of 72 male Wistar rats and osseointegration was studied on Days 15 and 40. Biomechanical testing, micro-computed microtomography, and histomorphometric analyses were performed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Biomechanical testing reveals that after 15 days of healing, removal torque increased from 2.5 Ncm (1.5–4.4) to 3.9 Ncm (1.7–7.6) when comparing SBF alone with SBF containing ODN, respectively (<i>p</i> = 0.017). Consistently, micro-computed microtomography indicated that local bone volume increased from 24.4% (13.86–32.45) to 32.8% (19.7–39.4), respectively (<i>p</i> = 0.003). The same was true for presumed bone-to-implant contact, which was 34.38% (27.0–50.0) and 43.33% (31.6–54.2), respectively (<i>p</i> = 0.035). Histomorphometric analyses confirmed that the new bone area per total area increased from 34.78% (18.9–43.7) to 41.10% (23.5–54.0), respectively (<i>p</i> = 0.102). This trend proceeds after 40 days of osseointegration.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Discussion</h3>\u0000 \u0000 <p>These findings suggest that topical delivery of a cathepsin K inhibitor can support the early osseointegration phase in an ectopic rodent implantation model.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"36 12","pages":"1640-1650"},"PeriodicalIF":5.3,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/clr.70038","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144995877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
To assess the factors influencing the survival and success rates of narrow diameter implants (NDIs) placed in the posterior area; additionally, the study evaluated marginal bone changes, along with biological and prosthetic complications.
Materials and Methods
This retrospective single-center study investigated the clinical and radiographic outcomes of 227 NDIs placed in the premolar and molar regions of 119 patients. The analysis focused on implant survival and success rates, marginal bone levels (MBL), and the incidence of biological and mechanical complications. Generalized estimating equations (GEE) were employed to assess the impact of patient- and implant-related characteristics on these outcomes.
Results
Over a mean follow-up period of 11.51 years (SD: 4.03) the study recorded the loss of 12 NDIs in seven patients. The Kaplan–Meier survival rates were 90.3% (95% CI: 85.4%–95.4%) and 85.7% (95% CI: 77.2%–95.0%) respectively. The average marginal bone loss (MBL) was estimated at −0.75 (SD 1.34) mm. Mucositis was observed in 33.18% of the implants and peri-implantitis in 9.86% of the sample.
Conclusion
This study offers valuable understanding of NDIs as a predictable option in implant dentistry, particularly for patients with challenging anatomical conditions. However, careful case selection and comprehensive treatment planning are crucial to minimize the risk of implant fractures.
{"title":"Long-Term Evaluation of Narrow-Diameter Dental Implants in Posterior Sites in Patients With History of Periodontitis: A Retrospective Study With an 11.5-Year Mean Follow-Up","authors":"Maria Costanza Soldini, Isabel Arroyo, Riccardo Peragine, Enrique Roldán, Cristina Valles, Ramón Pons","doi":"10.1111/clr.70028","DOIUrl":"10.1111/clr.70028","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To assess the factors influencing the survival and success rates of narrow diameter implants (NDIs) placed in the posterior area; additionally, the study evaluated marginal bone changes, along with biological and prosthetic complications.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>This retrospective single-center study investigated the clinical and radiographic outcomes of 227 NDIs placed in the premolar and molar regions of 119 patients. The analysis focused on implant survival and success rates, marginal bone levels (MBL), and the incidence of biological and mechanical complications. Generalized estimating equations (GEE) were employed to assess the impact of patient- and implant-related characteristics on these outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Over a mean follow-up period of 11.51 years (SD: 4.03) the study recorded the loss of 12 NDIs in seven patients. The Kaplan–Meier survival rates were 90.3% (95% CI: 85.4%–95.4%) and 85.7% (95% CI: 77.2%–95.0%) respectively. The average marginal bone loss (MBL) was estimated at −0.75 (SD 1.34) mm. Mucositis was observed in 33.18% of the implants and peri-implantitis in 9.86% of the sample.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study offers valuable understanding of NDIs as a predictable option in implant dentistry, particularly for patients with challenging anatomical conditions. However, careful case selection and comprehensive treatment planning are crucial to minimize the risk of implant fractures.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"36 12","pages":"1535-1550"},"PeriodicalIF":5.3,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144944919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Christian Mertens, Fabian Staudinger, Maximilian Smielowski, Thomas Rückschloss, Gregor Schnug, Jürgen Hoffmann, Oliver Ristow
Objective and Aim
A retrospective study to evaluate the clinical and radiological outcomes of dental implants placed in compromised patients who have undergone antiresorptive therapy (AR) or head and neck radiotherapy (IR).
Material and Methods
Dental implant placement was evaluated in compromised patients undergoing or after receiving AR/IR therapy following specific preventive measures: antibiotic prophylaxis (2 days before and 5 days after surgery) and primary wound closure with submerged healing for 4 months. The primary outcome was implant survival during the observation period. Secondary outcomes included marginal bone loss, occurrence of osteonecrosis, and factors influencing implant survival.
Results
A total of 92 patients (59 IR, 32 AR) with 369 dental implants were included in the study. During a mean follow-up period of 25 months (SD: 16), 23 implants were lost (IR: 21, AR: 2). Implant survival rates were 92% and 98% for IR and AR, respectively. Identified risk factors for implant failure included placement in neomandibular/−maxillary sites, maxillary implantation, implant diameter < 4.2 mm, active smoking, and diabetes mellitus. The mean marginal bone loss was 0.57 mm (SD: 1.51) in the IR group and −0.09 mm (SD: 1.17) in the AR group.
Conclusion
With comprehensive risk assessment and careful evaluation of implant indications, dental implants can serve as an effective dental rehabilitation option for patients undergoing or after receiving AR/IR therapy, provided strict adherence to preventive measures is maintained. Implants placed following AR therapy demonstrate higher survival rates and reduced marginal bone loss compared to those placed after IR therapy.
目的和目的回顾性研究，评估接受抗吸收治疗（AR）或头颈部放疗（IR）的受损患者种植牙的临床和放射学结果。材料和方法对正在接受AR/IR治疗或在接受AR/IR治疗后的受损患者进行评估，并采取具体的预防措施：抗生素预防（手术前2天和手术后5天）和4个月的初级伤口愈合。主要观察指标为观察期间种植体的存活。次要结局包括边缘骨质流失、骨坏死的发生和影响种植体存活的因素。结果共纳入92例患者（IR 59例，AR 32例），种植体369颗。在平均25个月的随访期间（SD: 16）， 23个种植体丢失（IR: 21, AR: 2）。IR和AR的种植体存活率分别为92%和98%。确定的种植体失败的危险因素包括在下颌/上颌位置放置、上颌种植、种植体直径4.2 mm、吸烟和糖尿病。IR组的平均边缘骨丢失为0.57 mm (SD: 1.51)， AR组的平均边缘骨丢失为- 0.09 mm （SD: 1.17）。结论在严格遵守预防措施的前提下，通过全面的风险评估和对种植指征的仔细评估，种植体可以作为正在接受AR/IR治疗或接受AR/IR治疗后的患者有效的牙科康复选择。与IR治疗后放置的植入物相比，AR治疗后放置的植入物具有更高的存活率和更少的边缘骨质流失。
{"title":"Dental Implants in Medically Compromised Patients Undergoing or After Receiving Anti-Resorptive or Radiotherapy: Retrospective Clinical and Radiographic Data","authors":"Christian Mertens, Fabian Staudinger, Maximilian Smielowski, Thomas Rückschloss, Gregor Schnug, Jürgen Hoffmann, Oliver Ristow","doi":"10.1111/clr.70040","DOIUrl":"10.1111/clr.70040","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective and Aim</h3>\u0000 \u0000 <p>A retrospective study to evaluate the clinical and radiological outcomes of dental implants placed in compromised patients who have undergone antiresorptive therapy (AR) or head and neck radiotherapy (IR).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>Dental implant placement was evaluated in compromised patients undergoing or after receiving AR/IR therapy following specific preventive measures: antibiotic prophylaxis (2 days before and 5 days after surgery) and primary wound closure with submerged healing for 4 months. The primary outcome was implant survival during the observation period. Secondary outcomes included marginal bone loss, occurrence of osteonecrosis, and factors influencing implant survival.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 92 patients (59 IR, 32 AR) with 369 dental implants were included in the study. During a mean follow-up period of 25 months (SD: 16), 23 implants were lost (IR: 21, AR: 2). Implant survival rates were 92% and 98% for IR and AR, respectively. Identified risk factors for implant failure included placement in neomandibular/−maxillary sites, maxillary implantation, implant diameter < 4.2 mm, active smoking, and diabetes mellitus. The mean marginal bone loss was 0.57 mm (SD: 1.51) in the IR group and −0.09 mm (SD: 1.17) in the AR group.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>With comprehensive risk assessment and careful evaluation of implant indications, dental implants can serve as an effective dental rehabilitation option for patients undergoing or after receiving AR/IR therapy, provided strict adherence to preventive measures is maintained. Implants placed following AR therapy demonstrate higher survival rates and reduced marginal bone loss compared to those placed after IR therapy.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"36 12","pages":"1651-1663"},"PeriodicalIF":5.3,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/clr.70040","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144930179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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