Clinical Physiology and Functional Imaging最新文献_第4页

The value of the HFA-PEFF and H2FPEF scores in determining the phenotypes and comorbidity burden in heart failure with preserved ejection fraction HFA-PEFF和H2FPEF评分在确定保留射血分数的心力衰竭的表型和合并症负担中的价值

IF 1.3 4区医学 Q4 PHYSIOLOGY

Clinical Physiology and Functional Imaging

Pub Date : 2025-06-20 DOI: 10.1111/cpf.70019

Selda Murat, Bektas Murat, Halit Emre Yalvac, Fatih Enes Durmaz, Duygu Inan, Ahmet Celik, Yuksel Cavusoglu

Background

The HFA-PEFF and H2FPEF scores are widely used for diagnosing heart failure with preserved ejection fraction (HFpEF). However, HFpEF is a heterogeneous condition with multiple phenotypes influenced by comorbidities and etiologies.

Objectives

This study aimed to evaluate the performance and agreement of these scoring systems across different HFpEF phenotypes and identify additional echocardiographic and clinical parameters that may improve phenotyping.

Methods

A total of 194 HFpEF patients were classified into three phenotypes: (1) common metabolic group, (2) atrial fibrillation (AF)-predominant group, and (3) hypertension with left ventricular hypertrophy group. The clinical, laboratory, and echocardiographic characteristics of these phenotypes were analyzed. The agreement and performance between HFA-PEFF and H2FPEF scores for phenotypes in HFpEF patients were assessed.

Results

A total of 194 HFpEF patients were included. While 92.3% of patients had a high HFA-PEFF score, only 42.8% had a high H2FPEF score. The agreement between these scoring methods was low across all phenotypes. Phenotype-specific differences were observed: interventricular septal thickness was highest in phenotype 3, systolic pulmonary artery pressure (SPAP) was highest in phenotype 2, and left atrial reservoir strain (LASr) and right ventricular free wall longitudinal strain (RV-FWLS) were lowest in phenotype 2.

Conclusion

The HFA-PEFF and H2FPEF scores showed limited agreement in distinguishing HFpEF phenotypes. Additional echocardiographic parameters such as IVS thickness, SPAP, LASr, and RV-FWLS may enhance phenotypic differentiation and improve HFpEF classification. A more refined diagnostic approach incorporating these parameters could guide personalized treatment strategies.

HFA-PEFF和H2FPEF评分被广泛用于诊断保留射血分数（HFpEF）心力衰竭。然而，HFpEF是一种异质性疾病，具有多种表型，受合并症和病因的影响。本研究旨在评估这些评分系统在不同HFpEF表型中的表现和一致性，并确定可能改善表型的其他超声心动图和临床参数。方法将194例HFpEF患者分为3种表型：(1)普通代谢组，(2)心房颤动（AF）为主组，(3)高血压合并左室肥厚组。分析了这些表型的临床、实验室和超声心动图特征。评估HFA-PEFF和H2FPEF评分在HFpEF患者表型上的一致性和表现。结果共纳入194例HFpEF患者。92.3%的患者有高HFA-PEFF评分，只有42.8%的患者有高H2FPEF评分。这些评分方法之间的一致性在所有表型中都很低。表型特异性差异：表型3的室间隔厚度最高，表型2的肺动脉收缩压（SPAP）最高，表型2的左心房储层应变（LASr）和右心室自由壁纵向应变（RV-FWLS）最低。结论HFA-PEFF和H2FPEF评分在区分HFpEF表型方面一致性有限。其他超声心动图参数如IVS厚度、SPAP、LASr和RV-FWLS可能会增强表型分化并改善HFpEF的分类。结合这些参数的更精细的诊断方法可以指导个性化的治疗策略。

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引用次数: 0

Effects of gender, age and method variations on contractility in extremity lymphatic collectors using indocyanine green fluorescence lymphangiography 性别、年龄和方法变化对使用吲哚菁绿荧光淋巴管造影的四肢淋巴收集器收缩性的影响

IF 1.3 4区医学 Q4 PHYSIOLOGY

Clinical Physiology and Functional Imaging

Pub Date : 2025-06-15 DOI: 10.1111/cpf.70017

Mads Fich Lønnee, Mads Radmer Jensen, Bryan Haddock, Lene Simonsen, Tonny Karlsmark, Jens Bülow

The objectives of this study were to examine how extremity lymphatic collector contraction frequency is influenced by gender, age, and methodological variations in indocyanine green (ICG) injection using near infrared fluorescence (NIRF) imaging in healthy adults. Ten women (19–46 years) and eight men (18–59 years) were examined with 30-min NIRF videos recorded at different time points 0–150 min after injection of ICG. Variations in ICG volume (0.1 mL vs. 0.3 mL), -concentration (1 mg/mL vs. 2.5 mg/mL), -injection site (hand vs. foot), -route of administration (subcutaneous vs. intradermal) were applied to all subjects. The primary outcome was mean contraction frequency with maximum contraction frequency and number of visualised extremity lymphatic collectors as secondary outcomes. The median of mean contraction frequencies for females and males were 0.42 min⁻¹ (IQR 0,19 min⁻¹) and 0.25 min⁻¹ (IQR 0,15 min⁻¹), respectively (p = 0.022). The median of maximum contraction frequencies for females and males were 0.70 min⁻¹ (IQR 0,26 min⁻¹) and 0.34 min⁻¹ (IQR 0,15 min⁻¹), respectively (p = 0.015). Neither age, method variations nor imaging delay had any significant effect on contraction frequencies. Number of visualised collectors increased slightly during 150 min (p = 0.02). Mean and maximum contraction frequencies were significantly higher in women compared to men. This is a novel finding that warrants verification in future studies. Contraction frequency measured with 30-min NIRF imaging using an ICG volume as little as 0.1 mL and a concentration of 1 mg/mL is seemingly robust and readily available. This method is recommendable for perturbation studies of lymphatic collector function and pathophysiology.

本研究的目的是利用近红外荧光（NIRF）成像技术研究健康成人注射吲哚菁绿（ICG）时，性别、年龄和方法变化对下肢淋巴收集器收缩频率的影响。10名女性（19-46岁）和8名男性（18-59岁）在注射ICG后0-150分钟的不同时间点记录30分钟NIRF视频。ICG体积（0.1 mL vs. 0.3 mL）、浓度（1mg /mL vs. 2.5 mg/mL）、注射部位（手vs.脚）、给药途径（皮下vs.皮内）的变化应用于所有受试者。主要结果是平均收缩频率，最大收缩频率和可见的四肢淋巴收集器数量作为次要结果。女性和男性的平均收缩频率中位数分别为0.42 min−1 （IQR 0,19 min−1）和0.25 min−1 (IQR 0,15 min−1)（p = 0.022）。女性和男性的最大收缩频率中位数分别为0.70 min−1 （IQR 0,26 min−1）和0.34 min−1 (IQR 0,15 min−1)（p = 0.015）。年龄、方法变化和成像延迟对收缩频率均无显著影响。在150分钟内，可视化收集器的数量略有增加（p = 0.02）。女性的平均和最大宫缩频率明显高于男性。这是一个新颖的发现，值得在未来的研究中验证。使用ICG体积低至0.1 mL，浓度为1mg /mL，用30分钟NIRF成像测量收缩频率似乎是可靠的，并且容易获得。该方法适用于淋巴收集功能和病理生理的摄动研究。

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引用次数: 0

Evaluation of [18F]PSMA-1007 uptake variability in patients with prostate cancer 前列腺癌患者PSMA-1007摄取变异性的评价[18F]

IF 1.3 4区医学 Q4 PHYSIOLOGY

Clinical Physiology and Functional Imaging

Pub Date : 2025-06-15 DOI: 10.1111/cpf.70016

Elin Trägårdh, Måns Larsson, David Minarik, Olof Enqvist, Lars Edenbrandt

Background

The biodistribution of PSMA-ligands is of interest in radionuclide therapy planning. We investigated the variability of [¹⁸F]PSMA-1007 uptake in organs at risk and in relation to tumour burden in prostate cancer patients.