Clinical Physiology and Functional Imaging最新文献_第5页

Is musculoskeletal pain associated with increased muscle stiffness? Evidence map and critical appraisal of muscle measurements using shear wave elastography 肌肉骨骼疼痛与肌肉僵硬度增加有关吗？- 使用剪切波弹性成像技术测量肌肉的证据图和批判性评估。

IF 1.8 4区医学 Q4 PHYSIOLOGY

Clinical Physiology and Functional Imaging

Pub Date : 2023-12-28 DOI: 10.1111/cpf.12870

Andreas Haueise, Guillaume Le Sant, Angelika Eisele-Metzger, Angela V. Dieterich

Introduction and Aims

Approximately 21% of the world's population suffers from musculoskeletal conditions, often associated with sensations of stiff muscles. Targeted therapy requires knowing whether typically involved muscles are objectively stiffer compared to asymptomatic individuals. Muscle stiffness is quantified using ultrasound shear wave elastography (SWE). Publications on SWE-based comparisons of muscle stiffness between individuals with and without musculoskeletal pain are increasing rapidly. This work reviewed and mapped the existing evidence regarding objectively measured muscle stiffness in musculoskeletal pain conditions and surveyed current methods of applying SWE to measure muscle stiffness.

Methods

A systematic search was conducted in PubMed and CINAHL using the keywords “muscle stiffness”, “shear wave elastography”, “pain”, “asymptomatic controls” and synonyms. The search was supplemented by a hand search using Google Scholar. Included articles were critically appraised with the AXIS tool, supplemented by items related to SWE methods. Results were visually mapped and narratively described.

Results

Thirty of 137 identified articles were included. High-quality evidence was missing. The results comprise studies reporting lower stiffness in symptomatic participants, no differences between groups and higher stiffness in symptomatic individuals. Results differed between pain conditions and muscles, and also between studies that examined the same muscle(s) and pathology. The methods of the application of SWE were inconsistent and the reporting was often incomplete.

Conclusions

Existing evidence regarding the objective stiffness of muscles in musculoskeletal pain conditions is conflicting. Methodological differences may explain most of the inconsistencies between findings. Methodological standards for SWE measurements of muscles are urgently required.

导言和目的：全球约有 21% 的人患有肌肉骨骼疾病，这些疾病通常与肌肉僵硬的感觉有关。要进行有针对性的治疗，就必须了解与无症状的人相比，受影响的肌肉是否明显僵硬。肌肉僵硬可通过超声剪切波弹性成像（SWE）进行量化。基于 SWE 对肌肉骨骼疼痛患者和无肌肉骨骼疼痛患者的肌肉僵硬度进行比较的文献正在迅速增加。本研究回顾并绘制了有关肌肉骨骼疼痛情况下客观测量肌肉僵硬度的现有证据，并调查了目前应用 SWE 测量肌肉僵硬度的方法：在 PubMed 和 CINAHL 中使用关键词 "肌肉僵硬度"、"剪切波弹性成像"、"疼痛"、"无症状对照组 "和同义词进行了系统检索。此外，还使用 Google Scholar 进行了人工搜索。使用 AXIS 工具对纳入的文章进行了严格评估，并补充了与剪切波弹性成像方法相关的项目。对结果进行了视觉映射和叙述性描述：在 137 篇已确定的文章中，有 30 篇被收录。缺少高质量的证据。结果包括报告有症状的参与者僵硬度较低、组间无差异以及有症状的个体僵硬度较高的研究。不同的疼痛情况和肌肉，以及检查相同肌肉和病理的研究之间的结果也不尽相同。应用SWE的方法不一致，报告也往往不完整：结论：有关肌肉骨骼疼痛情况下肌肉客观僵硬度的现有证据相互矛盾。方法上的差异可能是导致研究结果不一致的主要原因。迫切需要制定肌肉 SWE 测量方法标准。本文受版权保护。保留所有权利。

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引用次数: 0

Impact of a cuff-based device calibration method on the agreement between invasive and noninvasive aortic and brachial pressure 基于袖带的装置校准方法对有创与无创主动脉和肱动脉压力一致性的影响。

IF 1.8 4区医学 Q4 PHYSIOLOGY

Clinical Physiology and Functional Imaging

Pub Date : 2023-11-28 DOI: 10.1111/cpf.12869

Daniel Bia, Federico Salazar, Luis Cinca, Marcos Gutierrez, Álvaro Facta, Alejandro Diaz, Yanina Zócalo

Introduction

Brachial cuff-based methods are increasingly used to estimate aortic systolic blood pressure (aoSBP). However, there are several unresolved issues.

Aims

to determine to what extent the scheme used to calibrate brachial records (1) can affect noninvasive obtained aoSBP levels, and consequently, the level of agreement with the aoSBP recorded invasively, and (2) how different ways of calibrating ultimately impact the relationship between aoSBP and cardiac properties.

Methods

brachial and aortic blood pressure (BP) was simultaneously obtained by invasive (catheterisation) and noninvasive (brachial oscillometric-device) methods (89 subjects). aoSBP was noninvasive obtained using three calibration schemes: ‘SD’: diastolic and systolic brachial BP, ‘C’: diastolic and calculated brachial mean BP (bMBP), ‘Osc’: diastolic and oscillometry-derived bMBP. Agreement between invasive and noninvasive aoSBP, and associations between BP and echocardiographic-derived parameters were analysed.

Conclusions

‘C’ and ‘SD’ schemes generated aoSBP levels lower than those recorded invasively (mean errors: 6.9 and 10.1 mmHg); the opposite was found when considering ‘Osc’(mean error: −11.4 mmHg). As individuals had higher invasive aoSBP, the three calibration schemes increasingly underestimated aoSBP levels; and viceversa. The ‘range’ of invasive aoSBP in which the calibration schemes reach the lowest error level (−5–5 mmHg) is different: ‘C’: 103–131 mmHg; ‘Osc’: 159–201 mmHg; ‘SD’:101-124 mmHg. The calibration methods allowed reaching levels of association between aoSBP and cardiac characteristics, somewhat lower, but very similar to those obtained when considering invasive aoSBP. There is no evidence of a clear superiority of one calibration method over another when considering the association between aoSBP and cardiac characteristics.

基于肱袖带的方法越来越多地用于估计主动脉收缩压(aoSBP)。然而，仍有几个未解决的问题。目的:确定用于校准肱动脉记录的方案在多大程度上(i)可以影响无创获得的aoSBP水平，从而影响与有创记录的aoSBP的一致程度，以及(ii)不同的校准方法最终如何影响aoSBP与心脏特性之间的关系。方法:89例受试者采用有创(导管)和无创(肱动脉示波仪)方法同时测量肱动脉和主动脉血压(BP)。aoSBP采用三种校准方案无创获得:“SD”:舒张和收缩期肱BP，“C”:舒张和计算肱平均BP (bMBP)，“Osc”:舒张和振荡测量得出的bMBP。分析有创和无创aoSBP之间的一致性，以及BP与超声心动图衍生参数之间的相关性。结论:“C”和“SD”方案产生的aoSBP水平低于有创记录(平均误差:6.9和10.1 mmHg);当考虑“Osc”时，结果正好相反(平均误差:-11.4 mmHg)。随着个体侵入性aoSBP的升高，三种定标方案对aoSBP水平的低估程度越来越低;,反之亦然。各校准方案达到最低误差水平(-5 ~ 5 mmHg)的有创aoSBP“范围”不同:“C”:103 ~ 131 mmHg;' Osc ': 159-201 mmHg;´SD´:101 - 124毫米汞柱。校准方法允许达到aoSBP与心脏特征之间的关联水平，稍微低一些，但与考虑有创性aoSBP时获得的关联水平非常相似。在考虑aoSBP与心脏特征之间的关系时，没有证据表明一种校准方法明显优于另一种校准方法。这篇文章受版权保护。版权所有。

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引用次数: 0

Metabolic tumour volume in Hodgkin lymphoma—A comparison between manual and AI-based analysis 霍奇金淋巴瘤的代谢肿瘤体积-人工和人工智能分析的比较。

IF 1.8 4区医学 Q4 PHYSIOLOGY

Clinical Physiology and Functional Imaging

Pub Date : 2023-11-27 DOI: 10.1111/cpf.12868

May Sadik, Sally F. Barrington, Elin Trägårdh, Babak Saboury, Anne L. Nielsen, Annika L. Jakobsen, Jose L. L. Gongora, Jesus L. Urdaneta, Rajender Kumar, Lars Edenbrandt

Aim

To compare total metabolic tumour volume (tMTV), calculated using two artificial intelligence (AI)-based tools, with manual segmentation by specialists as the reference.

Methods

Forty-eight consecutive Hodgkin lymphoma (HL) patients staged with [18F] fluorodeoxyglucose positron emission tomography/computed tomography were included. The median age was 35 years (range: 7–75), 46% female. The tMTV was automatically measured using the AI-based tools positron emission tomography assisted reporting system (PARS) (from Siemens) and RECOMIA (recomia.org) without any manual adjustments. A group of eight nuclear medicine specialists manually segmented lesions for tMTV calculations; each patient was independently segmented by two specialists.

Results

The median of the manual tMTV was 146 cm³ (interquartile range [IQR]: 79–568 cm³) and the median difference between two tMTV values segmented by different specialists for the same patient was 26 cm³ (IQR: 10–86 cm³). In 22 of the 48 patients, the manual tMTV value was closer to the RECOMIA tMTV value than to the manual tMTV value segmented by the second specialist. In 11 of the remaining 26 patients, the difference between the RECOMIA tMTV and the manual tMTV was small (<26 cm³, which was the median difference between two manual tMTV values from the same patient). The corresponding numbers for PARS were 18 and 10 patients, respectively.

Conclusion

The results of this study indicate that RECOMIA and Siemens PARS AI tools could be used without any major manual adjustments in 69% (33/48) and 58% (28/48) of HL patients, respectively. This demonstrates the feasibility of using AI tools to support physicians measuring tMTV for assessment of prognosis in clinical practice.

目的:比较两种基于人工智能(AI)的工具计算的总代谢肿瘤体积(tMTV)，并以专家人工分割为参考。方法:采用[18F]FDG PET/CT分期的48例连续霍奇金淋巴瘤(HL)患者。中位年龄为35岁(范围7-75岁)，46%为女性。使用基于人工智能的工具PARS(来自Siemens)和recoia (recoma.org)自动测量tMTV，无需任何手动调整。一组8名核医学专家手动分割病变进行tMTV计算;每位患者由两位专家独立分割。结果:手工tMTV的中位数为146 cm3(四分位间距(IQR) 79 ~ 568 cm3)，不同专科对同一患者分割的两次tMTV值的中位数差为26 cm3 (IQR 10 ~ 86 cm3)。在48例患者中，有22例患者的手动tMTV值更接近recoia tMTV值，而不是第二专科医生分割的手动tMTV值。在其余26例患者中，11例recoia tMTV与手动tMTV之间的差异很小(3，这是同一患者两次手动tMTV值之间的中位数差异)。PARS对应的数字分别为18例和10例。结论:本研究结果表明，69%(33/48)的hl患者可以使用recoia和58%(28/48)的Siemens PARS AI工具，而无需任何人工调整。这证明了在临床实践中使用人工智能工具来支持医生测量tMTV以评估预后的可行性。这篇文章受版权保护。版权所有。

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引用次数: 0

Right ventricular function in severe aortic stenosis assessed by echocardiography and MRI 超声心动图和MRI评价重度主动脉瓣狭窄患者的右心室功能。

IF 1.8 4区医学 Q4 PHYSIOLOGY

Clinical Physiology and Functional Imaging

Pub Date : 2023-11-20 DOI: 10.1111/cpf.12867

Erica Holmberg, Éva Tamás, Eva Nylander, Jan Engvall, Hans Granfeldt

Background

The prevalence of aortic valve stenosis (AS) is increasing due to an ageing population. Despite that right ventricular function has prognostic value for postoperative outcome, the right ventricle (RV) is not extensively studied and often not routinely assessed in AS. Our aim was to explore the relation between severe AS and RV function in a surgical aortic valve replacement (SAVR) cohort, comparing two imaging modalities for RV evaluation.

Methods

Patients with severe AS, underwent cardiovascular magnetic resonance imaging (CMR) and transthoracic echocardiography (TTE) before SAVR. RV dysfunction was defined as one or more of the following: tricuspid annular plane systolic excursion (TAPSE) < 17 mm, RV free wall strain (RVFWS) > −20% by TTE and RV ejection fraction (RVEF) <50% by CMR.

Results

Sixteen (33%) patients were found to have RV dysfunction. Patients with RV dysfunction showed significantly lower indexed aortic valve area, left ventricular (LV) ejection fraction as well as RV and LV stroke volumes compared to patients with maintained RV function. All patients with reduced RVEF also had changes in TAPSE or RVFWS and a larger number of patients had a reduced longitudinal RV function despite a normal RVEF.

Conclusion

In a SAVR cohort one-third of the patients had RV dysfunction, defined by RVEF, TAPSE or RVFW strain. Echocardiography detected subtle changes in RV function before RVEF was reduced. It is likely that the more pronounced the AS, the more frequent the occurrence of RV dysfunction.

背景:由于人口老龄化，主动脉瓣狭窄(AS)的患病率正在上升。尽管右心室功能对术后预后有预测价值，但在AS患者中，右心室(RV)并没有得到广泛的研究，通常也没有进行常规评估。我们的目的是探讨在外科主动脉瓣置换术(SAVR)队列中严重AS与RV功能之间的关系，比较两种成像方式对RV的评估。方法:重度AS患者在SAVR前行心血管磁共振成像(CMR)和经胸超声心动图(TTE)检查。右心室功能障碍定义为以下一项或多项:三尖瓣环面收缩漂移(TAPSE) < 17 mm, TTE检测右心室游离壁应变(RVFWS) > -20%， CMR检测右心室射血分数(RVEF) < 50%。结果:16例(33%)患者有右心室功能障碍。与左室功能维持的患者相比，右室功能障碍患者的主动脉瓣指数面积、左室射血分数以及左室和左室卒中容量明显降低。所有RVEF减少的患者也有TAPSE或RVFWS的变化，尽管RVEF正常，但大量患者的纵向RV功能降低。结论:在SAVR队列中，三分之一的患者有RVEF、TAPSE或RVFW菌株定义的RV功能障碍。超声心动图检测到RVEF减少前右室功能的细微变化。AS越明显，RV功能障碍的发生就越频繁。这篇文章受版权保护。版权所有。

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引用次数: 0

The effect of lower limb strengthening exercise on orthostatic blood pressure and the skeletal muscle pump in older people with orthostatic hypotension 下肢强化运动对老年人体位性低血压和骨骼肌泵的影响。

IF 1.8 4区医学 Q4 PHYSIOLOGY

Clinical Physiology and Functional Imaging

Pub Date : 2023-11-17 DOI: 10.1111/cpf.12866

James Frith, Lisa Robinson, Jake Ryan Gibbon, John Allen

Introduction

Activation of muscles during standing is recommended to activate the skeletal muscle pump, increasing venous return and increasing blood pressure (BP) in people with orthostatic hypotension (OH).

Aim

The aim of this study is to determine if increasing the strength of the lower limb muscles can improve the effectiveness of the venous pump and postural BP in older people with OH.

Methods

Ten older people with OH underwent an 8-week lower limb strengthening intervention. Repeated measurements of orthostatic BP, calf venous ejection fraction (EF) and muscle strength took place before, during and after intervention.

Results

The intervention increased calf muscle strength by 21% (interquartile range: 18–28), p = 0.018, from a median baseline of 38 (34–45) kg. Participants had normal levels of venous EF 64% (51–75) at baseline, with little to no venous reflux. The median ejection volume at baseline was 44 (36–58) mL per calf. Despite increasing muscle strength, venous EF did not increase (percentage change −10% (−16 to 24), p = 0.8) and systolic BP drop did not improve (percentage change 0% (−17 to 16), p = 1.0). Similarly, visual analysis of individual case-series trends revealed increasing muscle strength with no clinically meaningful change in EF or orthostatic BP.

Conclusions

Muscle strengthening exercise does not increase the effectiveness of the skeletal muscle pump and is not an efficacious intervention for OH. As there is little to no venous pooling in the calf during standing in older people with OH, below knee compression is unlikely to be clinically effective.

简介:建议在站立时激活肌肉，以激活骨骼肌泵，增加静脉回流，增加直立性低血压(OH)患者的血压(BP)。目的:确定增加下肢肌肉的力量是否可以改善老年人体位性低血压(OH)的静脉泵和体位性血压的有效性。方法:10例老年OH患者进行了为期8周的下肢强化干预。在干预之前、期间和之后，反复测量体位血压、小腿静脉射血分数和肌肉力量。结果:干预使小腿肌肉力量从38 (34 - 45)kg的中位基线增加了21% (IQR 18-28)， p=0.018。参与者在基线时静脉射血分数为64%(51 - 75)，几乎没有静脉回流。基线时的中位射血量为每头小牛44 (36 - 58)ml。尽管肌肉力量增加，但静脉射血分数没有增加(百分比变化-10%(-16至24)，p=0.8)，收缩压下降没有改善(百分比变化0%(-17至16)，p=1.0)。同样，个体病例系列趋势的视觉分析显示肌力增加，但射血分数或直立血压没有临床意义的变化。结论:肌肉强化运动不能增加骨骼肌泵的有效性，也不是OH的有效干预措施。由于老年OH患者站立时小腿几乎没有静脉淤积，因此膝关节以下压迫在临床上不太可能有效。这篇文章受版权保护。版权所有。

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引用次数: 0

A case of hemichorea associated with nonketotic hyperglycaemia: A new magnetic resonance spectroscopy (MRS) finding and possible future implications 一例与非酮症高血糖相关的血凝:一个新的磁共振波谱(MRS)发现和可能的未来意义。

IF 1.8 4区医学 Q4 PHYSIOLOGY

Clinical Physiology and Functional Imaging

Pub Date : 2023-11-14 DOI: 10.1111/cpf.12865

Assunta Trinchillo, Flavio Barchetti, Gabriella De Joanna, Marcello Esposito, Giovanni Piccirillo, Stefania Miniello

Background

Diabetic Striatopathy (DS) is a rare complication of a poor-controlled Diabetes Mellitus consisting of sudden onset of movement disorders. To date, there is still poor knowledge about the pathogenesis.

Case

We describe a 79 year old men affected by sudden onset hemichoreic movements whose cause was a non-ketotic hyperglycaemia diagnosed despite the normal blood glucose levels thanks to brain CT and magnetic resonance imaging. Then, we introduce a new magnetic resonance spectroscopy (MRS) finding never described until today which allowed us to produce a new pathogenetic theory of a phenomenon still without definitive explanations.

Literature Review

We performed a review of DS cases using the Medline database and we extracted main data regarding imaging findings.

Conclusions

Thanks to our MRS we show new imaging findings never described until today, with a new pathogenetic explanation, since all the causative hypotheses produced during the past years have never found evidence.

背景:糖尿病纹状体病(DS)是控制不良的糖尿病中一种罕见的并发症，包括突然发作的运动障碍。迄今为止，对其发病机制仍知之甚少。病例:我们描述了一位79岁的男性患者，他的病因是非酮症高血糖，尽管脑部CT和磁共振成像显示血糖水平正常。然后，我们引入了一种新的磁共振波谱(MRS)发现，直到今天才被描述，这使我们能够对一种仍然没有明确解释的现象产生新的发病理论。文献回顾:我们使用Medline数据库对退行性椎体滑移病例进行了回顾，并提取了有关影像学表现的主要数据。结论:多亏了我们的MRS，我们展示了新的影像学发现，直到今天才有了新的病理解释，因为过去几年产生的所有病因假设都没有找到证据。

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引用次数: 0

Relation of changes in PEF and FEV1 in exercise challenge in children 儿童运动挑战时PEF和FEV1变化的关系。

IF 1.8 4区医学 Q4 PHYSIOLOGY

Clinical Physiology and Functional Imaging

Pub Date : 2023-11-07 DOI: 10.1111/cpf.12864

Leon Csonka, Antti Tikkakoski, Anna P. Tikkakoski, Jussi Karjalainen, Lauri Lehtimäki

Decrease in forced expiratory volume in one second (FEV₁) of 10% or 15% in exercise challenge test is considered diagnostic for asthma, but a decrease of 15% in peak expiratory flow (PEF) is recommended as an alternative. Our aim was to assess the accuracy of different PEF cut-off points in comparison to FEV₁.

We retrospectively studied 326 free running exercise challenge tests with spirometry in children 6−16 years old. FEV₁ and PEF were measured before and 2, 5, 10 and 15 min after exercise. Receiver operating characteristics (ROC) analysis, sensitivity, specificity, positive and negative predictive values (PPV and NPV) and ϰ-coefficient were used to analyse how decrease in PEF predicts decrease of 10% or 15% in FEV₁.

In the ROC analysis, areas under the curve were 0.851 (p < 0.001) and 0.921 (p < 0.001) for PEF decrease to predict a 10% and 15% decrease in FEV₁, respectively. The agreement between changes in PEF and FEV₁ varied from slight to substantial (ϰ values of 0.199–0.680) depending on the cut-points. Lower cut-off for decrease in PEF had higher sensitivity and NPV, while higher cut-off values had better specificity and PPV. Decrease of 20% and 25% in PEF seemed to be the best cut-offs for detecting 10% and 15% decrease in FEV₁, respectively. Still, a fifth of the positive findings based on PEF were false.

Change in PEF is not a precise predictor of change in FEV₁ in exercise test. The currently recommended cut-point of 15% decrease in PEF seems to be too low and leads to high false positive rate.

运动激发试验中1秒用力呼气量（FEV1）降低10%或15%被认为是哮喘的诊断，但建议将呼气峰流量（PEF）降低15%作为替代方案。我们的目的是与FEV1相比，评估不同PEF截止点的准确性。我们回顾性研究了326例6-16岁儿童的自由跑运动挑战性肺活量测试。在运动前和运动后2、5、10和15分钟测量FEV1和PEF。ROC分析、敏感性、特异性、阳性和阴性预测值（PPV和NPV）以及kappa系数用于分析PEF的降低如何预测FEV1的降低10%或15%。在ROC分析中，曲线下的面积分别为0.851（p1）。PEF和FEV1的变化之间的一致性从轻微到显著不等（kappa值为0.199-0.680），具体取决于切割点。PEF降低的下限具有更高的灵敏度和NPV，而较高的下限值具有更好的特异性和PPV。PEF降低20%和25%似乎是检测FEV1分别降低10%和15%的最佳截止值。尽管如此，五分之一基于PEF的阳性结果是错误的。PEF的变化并不能准确预测运动测试中FEV1的变化。目前建议的PEF降低15%的分界点似乎太低，导致高假阳性率。这篇文章受版权保护。保留所有权利。

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引用次数: 0

Enhanced interleukin-6 in human adipose tissue vein after sprint exercise: Results from a pilot study 短跑运动后人体脂肪组织静脉中白细胞介素-6的增强：一项初步研究的结果。

IF 1.8 4区医学 Q4 PHYSIOLOGY

Clinical Physiology and Functional Imaging

Pub Date : 2023-10-29 DOI: 10.1111/cpf.12863

Mona Esbjörnsson, Barbara Norman, Moa Persson, Amarjit Saini, Jens Bülow, Eva Jansson

Background

Low-volume sprint exercise is likely to reduce body fat. Interleukin (IL-6) may mediate this by increasing adipose tissue (AT) lipolysis. Therefore, the exchange of AT IL-6 and glycerol, a marker of lipolysis, was examined in 10 healthy subjects performing three 30-s all-out sprints.

Methods

Blood samples were obtained from brachial artery (a) and a superficial subcutaneous vein (v) on the anterior abdominal wall up to 9 min after the last sprint and analysed for IL-6 and glycerol.

Results

Arterial IL-6 increased 2-fold from rest to last sprint. AT venous IL-6 increased 15-fold from 0.4 ± 0.4 at rest to 7.0 ± 4 pg × mL⁻¹ (p < 0.0001) and AT v–a difference increased 45-fold from 0.12 ± 0.3 to 6.0 ± 5 pg x mL⁻¹ (p < 0.0001) 9 min after last sprint. Arterial glycerol increased 2.5-fold from rest to 9 min postsprint 1 (p < 0.0001) and was maintained during the exercise period. AT venous and v–a difference of glycerol increased 2-fold from rest to 9 min postsprint 1 (p < 0.0001 and p = 0.01, respectively), decreased until 18 min postsprint 2 (p < 0.001 and p < 0.0001), and then increased again until 9 min after last sprint (both p < 0.01).

Conclusions

The concurrent increase in venous IL-6 and glycerol in AT after last sprint is consistent with an IL-6 induced lipolysis in AT. Glycerol data also indicated an initial increase in lipolysis after sprint 1 that was unrelated to IL-6. Increased IL-6 in adipose tissue may, therefore, complement other sprint exercise-induced lipolytic agents.

背景：小容量的短跑运动可能会减少身体脂肪。白细胞介素（IL-6）可能通过增加脂肪组织脂解来介导这种情况。因此，在进行三次30秒全力冲刺的10名健康受试者中，检测了脂肪组织（AT）IL-6和甘油（脂解的标志物）的交换。方法：在最后一次冲刺后9分钟内，从腹前壁的肱动脉（a）和皮下浅静脉（v）采集血样，并分析IL-6和甘油。结果：从休息到最后冲刺，动脉IL-6增加了2倍。AT静脉IL-6从静止时的0.4±0.4增加到7.0±4 pg x mL-1，增加了15倍（P＜0.0001），AT v-a差异从0.12±0.3增加到6.0±5 pg x mL-，增加了45倍（P＞0.0001）。从休息到冲刺1后9分钟，动脉甘油增加了2.5倍（P<0.0001），并在运动期间保持不变。从静止到冲刺1后9分钟，AT静脉和v-a甘油的差异增加了2倍（分别为P＜0.0001和P＝0.01），直到冲刺2后18分钟才降低（P＜0.001和P＜0.00001），结论：最后一次冲刺后脂肪组织中静脉IL-6和甘油的同时增加与IL-6诱导的脂肪组织脂解一致。甘油数据还表明，冲刺1后脂肪分解的最初增加与IL-6无关。因此，脂肪组织中IL-6的增加可能补充其他短跑运动诱导的脂肪分解剂。这篇文章受版权保护。保留所有权利。

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引用次数: 0

Influence of different time framings, reconstruction algorithms and post-processing methods on the quantification of myocardial blood flow from 13N-NH3 PET images 不同时间框架、重建算法和后处理方法对13N-NH3 PET图像心肌血流定量的影响。

IF 1.8 4区医学 Q4 PHYSIOLOGY

Clinical Physiology and Functional Imaging

Pub Date : 2023-10-26 DOI: 10.1111/cpf.12861

Shahnaz Akil, Anna E. Székely, Fredrik Hedeer, Berit Olsson, Henrik Engblom, Cecilia Hindorf

Background

The aim was to investigate to what extent the quantification of myocardial blood flow (MBF) from dynamic ¹³N-NH₃ positron emission tomography (PET) images is affected by time frame schemes, time-of-flight (ToF), reconstruction algorithms, blood pool volume of interest (VOI) locations and compartment models in patients with suspected chronic coronary syndrome.

Methods

A standard MBF value was determined from 25 patients' rest/stress ¹³N-NH₃ PET/CT images reconstructed with ordered subset expectation maximization (OSEM), 5 s time frame for the first frames without ToF, subsequently analyzed using a basal VOI and the deGrado compartment model. MBFs calculated using 2 or 10 s for the first frames, ToF, block-sequential regularized expectation maximization (BSREM), apical or large VOI, Hutchins or Krivokapich compartment models were compared to MBF_standard in Bland–Altman plots (bias ± SD).

Results

Good agreement in global rest/stress MBF (mL/min/g) was found when changing the time frame scheme or reconstruction algorithm (MBF_standard vs. MBF_2s: −0.02 ± 0.06; MBF_10s: 0.01 ± 0.07; MBF_BSREM: 0.01 ± 0.07), while a lower level of agreement was found when altering the other factors (MBF_standard vs. MBF_ToF: −0.07 ± 0.10; MBF_{apical VOI}: −0.27 ± 0.25; MBF_{large VOI}: −0.11 ± 0.10; MBF_Hutchins: −0.08 ± 0.10; MBF_Krivokapich: −0.47 ± 0.50).

Conclusions

Quantification of MBF from ¹³N-NH₃ PET images is more affected by choice of compartment models, ToF and blood pool VOIs than by different time frame schemes and reconstruction algorithms.

背景：目的是研究疑似慢性冠状动脉综合征患者的时间帧方案、飞行时间（ToF）、重建算法、感兴趣血池容积（VOI）位置和室模型对动态13N-NH3 PET图像中心肌血流（MBF）的量化的影响程度。方法：从25名患者的休息/应激13N-NH3 PET/CT图像中确定标准MBF值，该图像使用有序子集期望最大化（OSEM）重建，第一帧没有ToF的时间帧为5s，随后使用基础VOI和deGrado隔室模型进行分析。对于第一帧使用2s或10s计算的MBF、ToF、块顺序正则化期望最大化（BSREM）、顶点或大VOI，在Bland-Altman图中，将Hutchins或Krivokapich隔室模型与MBFstandard进行比较（偏差±SD）。结果：当改变时间框架方案或重建算法时，发现整体休息/应力MBF（ml/min/g）良好一致（MBFstandardvs MBF2s:-0.02±0.06；MBF10s:0.01±0.07；MBFBSREM:0.01±0.07），而当改变其他因素时，一致性较低（MBF标准与MBFToF:-0.07±0.10；MBFapical VOI:-0.27±0.25；MBFlarge VOI:-0.11±0.10；MBFHutchins:-0.08±0.10；MBFKrivokapich:-0.47±0.50），ToF和血池VOI。这篇文章受版权保护。保留所有权利。

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引用次数: 0

Impact of regular cold exposure on electrical skin resistance in patients with joint degenerative diseases 经常暴露在寒冷环境中对关节退行性疾病患者皮肤电阻的影响。

IF 1.8 4区医学 Q4 PHYSIOLOGY

Clinical Physiology and Functional Imaging

Pub Date : 2023-10-20 DOI: 10.1111/cpf.12862

Marcin Machnia, Wafa Douzi, Hela Jdidi, Elzbieta Miller, Benoit Dugué

Objective

Common features in chronic inflammatory disease patients (CIDP) are inflammation, mental stress (MS), and autonomic nervous system imbalance. Whole-body cryotherapy (WBC) exposure and regular physical exercise are known to regulate these features. In this study, we assessed the impact of regular physical exercise and the use of WBC exposure in CIDP on the level of electrical skin resistance (SR) to evaluate the skin sympathetic nervous activity and and estimate MS levels.

Methods

SR was evaluated before and after a 10-day-period of daily physical exercise preceded or not by WBC (3 min at −110°C) in two groups of 134 CIDP (WBC vs. non-WBC groups).

Results

At baseline, the number of severe MS patients was similar in both groups. However, after the training period, the number of severe MS patients significantly decreased in the WBC group, only. An increase in SR (a decrease in stress level) was noted in the WBC group only, and such increase was higher in men than in women and in patients younger than 60 versus patients older than 60 years old.

Conclusion

The use of daily WBC combined with physical exercise induced physiological adaptations and lowered the sympathetic nervous activity that may reflect a reduced level of MS in CIDP. These adaptations seem to depend on gender and age.

目的：慢性炎症性疾病（CIDP）患者的常见特征是炎症、精神压力（MS）和自主神经系统失衡。众所周知，全身冷冻治疗（WBC）暴露和定期体育锻炼可以调节这些特征。在本研究中，我们评估了定期体育锻炼和CIDP中WBC暴露对皮肤电阻（SR）水平的影响，以评估皮肤交感神经活动和估计MS水平。方法：在两组134 CIDP（WBC组与非WBC组）中，在WBC之前或之后的10天日常体育锻炼（在-110°C下3分钟）之前和之后评估SR。结果：在基线时，两组的严重MS患者数量相似。然而，训练期结束后，WBC组的严重MS患者数量显著减少，仅此而已。仅在WBC组中观察到SR的增加（压力水平的降低），男性的这种增加高于女性，60岁以下的患者高于60岁以上的患者。结论：每日WBC的使用与体育锻炼相结合可诱导生理适应并降低交感神经活动，这可能反映出CIDP的精神压力水平降低。这些适应似乎取决于性别和年龄。这篇文章受版权保护。保留所有权利。

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引用次数: 0