Clinical Physiology and Functional Imaging最新文献_第5页

Diaphragm thickness and physical performance in regular smokers and non-smokers: A pilot study 常规吸烟者和非吸烟者的隔膜厚度和身体表现：一项初步研究

IF 1.3 4区医学 Q4 PHYSIOLOGY

Clinical Physiology and Functional Imaging

Pub Date : 2025-03-04 DOI: 10.1111/cpf.70003

Bahar Özgül, Zübeyir Sarı, İlkşan Demirbüken, Hilal Başak Can, Zana Gezer, Halil Yıldırım, Mine Gülden Polat

Background

Despite the understanding of the role of diaphragm role as a crucial element in trunk stabilizer performance, limited research has been carried out on the diaphragmatic features particularly in smoking population.

Objectives

It was aimed to compare the diaphragm structure beside trunk stabilizer performance & body balance of young regular smokers and non-smokers and investigate the relationship between diaphragmatic features and physical performance in regular smokers.

Methods

Asymptomatic regular smoker (n = 22) and nonsmoker (n = 22) young male subjects (21.63 ± 2.37 years) were participated to the study. The diaphragmatic ultrasonic scanning and physical performance tests of core muscle strength and endurance & Y balance test were performed.

Results

The duration of prone and lateral side bridge (t = −3.347, t = 3.477, p < 0.001), and modify push-up test repetition (Z = −2.213, p = 0.027) were detected lower in regular smokers. A positive moderate correlation was observed between the duration of the prone bridge test and the maximum inspiration thickness & the thickness difference at inspiration and expiration (r = 0.545, p = 0.009 & r = 0.468, p = 0.028) and between the number of repetitions of the modify push-up and the maximum expiration thickness (r = 0.530, p = 0.011).

Conclusion

While no difference was detected in terms of the diaphragm structure between groups, trunk stabilizer performance was lower and greater diaphragm thickness was associated with better trunk stability in some performance tasks in smokers. While the diaphragm muscle structure, which is the main respiratory muscle, does not differ in young smokers, the effects of the diaphragm muscle on general body biomechanics have been preliminary demonstrated.

尽管人们已经认识到横隔膜在躯干稳定器性能中的关键作用，但对横隔膜特征的研究有限，特别是在吸烟人群中。目的比较尾翼侧横隔膜结构的性能；年轻吸烟者和非吸烟者的身体平衡，研究吸烟者膈肌特征与身体表现之间的关系。方法选取年龄（21.63±2.37）岁的无症状经常吸烟者（n = 22）和不吸烟者（n = 22）为研究对象。横膈膜超声扫描与核心肌力量耐力体能测试进行Y平衡试验。结果常规吸烟者俯卧桥和侧卧桥持续时间（t = - 3.347, t = 3.477, p < 0.001）和改良俯卧撑重复次数（Z = - 2.213, p = 0.027）明显低于常规吸烟者。俯卧桥试验持续时间与最大吸气厚度呈中等正相关；吸气和呼气时的厚度差(r = 0.545, p = 0.009；R = 0.468, p = 0.028)，修改俯卧撑重复次数与最大呼气厚度之间的关系（R = 0.530, p = 0.011）。结论抽烟者在某些表演任务中躯干稳定器的性能较低，而在膈膜厚度较大的情况下躯干稳定性较好。虽然作为主要呼吸肌的横膈肌结构在年轻吸烟者中没有差异，但横膈肌对全身生物力学的影响已经初步得到证实。

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引用次数: 0

Minimum detectable change estimates of heart-to-finger arterial pulse wave conduction time in cardiovascular-healthy young adults 心血管健康年轻人心脏到手指脉搏波传导时间的最小可检测变化估计

IF 1.3 4区医学 Q4 PHYSIOLOGY

Clinical Physiology and Functional Imaging

Pub Date : 2025-03-04 DOI: 10.1111/cpf.70002

Harvey N. Mayrovitz

Background

Pulse wave velocity (PWV) measurements are the gold standard for assessing arterial stiffness and estimating time or treatment-related changes in cardiovascular status. What constitutes a statistically significant change is an important clinical consideration. This study aimed to describe the variability of heart-to-finger pulse wave conduction time (PWCT) to provide estimates of the minimum detectable change (MDC) dependent on the number of PWCT samples used.

Materials and methods

Heart-to-finger PWCT was measured based on the time delay between the peak of the EKG R-wave and arterial pulse arrival at the left hand index finger as measured by a photoplethysmographic sensor. Measurements were done in 10 young adults (25.7 ± 1.2 years) while supine for 45 min. Depending on the subject's heart rate, these measurements yielded 2430 to 3750 contiguous PWCT for analysis. The variability in these PWCTs was used to determine the minimal detectable percentage change for specified p-values of 0.05, 0.01, and 0.001.

Results

Sample sizes of 10, 30, 50, or 300 contiguous PWCTs yield similar MDC estimates for a given targeted p-value. The MDC% depended on the chosen p-value, with values of MDC% for p-values of 0.05, 0.01, and 0.001 being 7.8%, 10.5%, and 13.6%.

Conclusions

The estimates may help plan experiments when changes or differences in PWCT or PWV are of interest. Also, these MDC estimates may help assess the validity of clinical study outcomes if PWV changes are outcome measures. The main limitation of the estimates is that they are based on 10 healthy subjects.

脉波速度（PWV）测量是评估动脉硬度和估计时间或治疗相关心血管状态变化的金标准。什么是统计上的显著变化是一个重要的临床考虑因素。本研究旨在描述心脏到手指脉冲波传导时间（PWCT）的可变性，以提供依赖于PWCT样本数量的最小可检测变化（MDC）的估计。材料与方法采用光电体积描记传感器测量心电图r波峰值与动脉脉冲到达左手食指的时间差，测量心-指PWCT。10名年轻成人（25.7±1.2岁）在仰卧45分钟时进行测量。根据受试者的心率，这些测量产生2430至3750个连续PWCT进行分析。这些pwct的变异性用于确定指定p值为0.05、0.01和0.001时的最小可检测百分比变化。结果对于给定的目标p值，10、30、50或300个连续pwct的样本量产生相似的MDC估计。MDC%取决于所选的p值，p值为0.05、0.01和0.001时，MDC%的值分别为7.8%、10.5%和13.6%。结论当对PWCT或PWV的变化或差异感兴趣时，这些估计可能有助于计划实验。此外，如果PWV变化是结果测量，这些MDC估计可能有助于评估临床研究结果的有效性。这些估计的主要局限性在于，它们是基于10名健康受试者。

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引用次数: 0

SVAT–sonographic thickness ratio of visceral adipose tissue to anterior thigh muscle: a novel approach for body composition analysis 内脏脂肪组织与大腿前肌的svat超声厚度比：一种新的身体成分分析方法

IF 1.3 4区医学 Q4 PHYSIOLOGY

Clinical Physiology and Functional Imaging

Pub Date : 2025-03-02 DOI: 10.1111/cpf.70004

Murat Kara, Ahmad J. Abdulsalam, Vincenzo Ricci, Levent Özçakar

Body composition analysis is essential for assessing health and fitness, providing insights into fat and muscle distribution in the body and serving as a vital indicator for various conditions. Traditional methods often lack precision, but ultrasound (US) has emerged as a noninvasive alternative. The intra-abdominal visceral adipose tissue to quadriceps muscle thickness ratio emerges as a significant indicator of metabolic health, offering clinicians a valuable tool for personalized interventions. With US, it represents a significant advancement in body composition analysis, promising detailed insights with its noninvasive and real-time imaging capabilities, likely expanding its role in improving human health assessment and interventions.

身体成分分析对于评估健康和健身是必不可少的，它提供了对体内脂肪和肌肉分布的洞察，并作为各种状况的重要指标。传统的方法往往缺乏精度，但超声（US）已成为一种无创的替代方法。腹内内脏脂肪组织与股四头肌厚度之比成为代谢健康的重要指标，为临床医生提供了个性化干预的宝贵工具。与US一起，它代表了身体成分分析的重大进步，有望通过其无创和实时成像功能提供详细的见解，可能扩大其在改善人类健康评估和干预方面的作用。

引用次数: 0

Pulmonary blood volume as a marker of adenosine-induced cardiac hyperemia: A Rubidium-82 study 肺血容量是腺苷诱发心脏充血的标志：铷-82研究

IF 1.3 4区医学 Q4 PHYSIOLOGY

Clinical Physiology and Functional Imaging

Pub Date : 2025-02-26 DOI: 10.1111/cpf.70001

Martin Lyngby Lassen, Jacob Peter Hartmann, Christina Byrne, Ronan M. G. Berg, Andreas Kjær, Philip Hasbak

Purpose

To investigate the efficacy of pulmonary blood volume (PBV) as a marker of the cardiac hyperemic response to adenosine during myocardial perfusion imaging (MPI).

Methods

Forty healthy subjects underwent four consecutive Rubidium-82 rest/adenosine-stress MPI: two sessions were conducted without any caffeine consumption (baseline), while the remaining two sessions involved controlled caffeine consumption (arm 1: 100 and 300 mg; arm 2: 200 and 400 mg). We evaluate the ability of the stress-to-rest ratio of PBV (PBV ratio) to identify an adequate cardiac hyperemic response. The adequate hyperemic response was defined as a stress myocardial blood flow >2 mL/g/min and a corresponding myocardial flow reserve >68% of the maximum myocardial flow reserve obtained during the baseline scans.

Results

Based on 126 MPI sessions conducted in 40 subjects, the PBV ratio demonstrated a sensitivity of 78% and a specificity of 74% in detecting adequate cardiac hyperemia. The positive predictive value was 95%, while the negative predictive value was 36%.

Conclusion

The PBV ratio permits the identification of adequate hyperemic response with sensitivities and specificities comparable to existing markers.

目的探讨肺血容量（PBV）在心肌灌注显像（MPI）中作为心脏对腺苷充血反应指标的作用。方法40名健康受试者连续接受4次铷-82休息/腺苷应激MPI，其中2次不摄入咖啡因（基线），其余2次控制咖啡因摄入(第1组：100和300 mg；组2:200和400毫克)。我们评估PBV的应激-休息比（PBV比）识别充分的心脏充血反应的能力。充分充血反应定义为应激心肌血流量为2ml /g/min，相应的心肌血流储备为基线扫描时获得的最大心肌血流储备的68%。结果基于40名受试者的126次MPI， PBV比值在检测足够的心脏充血方面的敏感性为78%，特异性为74%。阳性预测值为95%，阴性预测值为36%。结论PBV比值可识别充血反应，其敏感性和特异性与现有标志物相当。

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引用次数: 0

Renal clearance estimated by rubidium-82 positron emission tomography/computed tomography and technetium-99m-mercaptoacetyltriglycine clearance infusion technique 通过铷-82正电子发射断层扫描/计算机断层扫描和锝-99m-巯基乙酰甘油三酯清除输注技术估计肾脏清除率

IF 1.3 4区医学 Q4 PHYSIOLOGY

Clinical Physiology and Functional Imaging

Pub Date : 2025-02-23 DOI: 10.1111/cpf.70000

Stine Sundgaard Langaa, Camilla Lundgreen Duus, Marie Houmaa Vrist, Frank Holden Mose, Claire Anne Fynbo, Jørn Theil, June Anita Ejlersen, Jesper Nørgaard Bech

Background

Although numerous techniques exist for renal blood flow (RBF) estimation, none of the methods have been implemented in routine clinical practice due to their inadequacies and burdensomeness. Previously, we evaluated rubidium-82 (⁸²Rb) positron emission tomography/computed tomography (PET/CT) for renal perfusion determination and found strong indications of method precision and reliability. The aim of this study was to compare renal ⁸²Rb clearance with renal technetium-99m-mercaptoacetyltriglycine ([^99mTc]Tc-MAG3) clearance as a first attempt to validate ⁸²Rb PET/CT for renal perfusion estimation using a reference method.

Methods

Ten subjects with essential hypertension underwent two treatment periods, receiving spironolactone and placebo in random order. At the end of each period, each subject completed a ⁸²Rb PET/CT scan and a [^99mTc]Tc-MAG3 clearance study.

Results

⁸²Rb clearance correlated positively with [^99mTc]Tc-MAG3 clearance in both treatment periods. The [^99mTc]Tc-MAG3-to-⁸²Rb clearance ratio was 0.83 and 0.86 in the placebo and spironolactone treatment periods, respectively.

Conclusion

The correlation between ⁸²Rb clearance and [^99mTc]Tc-MAG3 clearance may indicate that PET/CT determined ⁸²Rb clearance can act as an estimator of renal perfusion. The [^99mTc]Tc-MAG3-to-⁸²Rb clearance ratios suggest that the extraction fraction of ⁸²Rb is higher than that of [^99mTc]Tc-MAG3, further suggesting ⁸²Rb clearance as an estimator of flow. However, further studies are warranted to validate use of ⁸²Rb PET/CT for flow estimation.

背景肾血流量（RBF）的估算方法有很多，但由于其不足和繁琐，没有一种方法在常规临床实践中得到应用。先前，我们评估了铷-82 （82Rb）正电子发射断层扫描/计算机断层扫描（PET/CT）用于肾脏灌注测定，并发现该方法具有很强的精确度和可靠性。本研究的目的是比较肾脏82Rb清除率与肾脏锝-99m-巯基乙酰三甘氨酸（[99mTc]Tc-MAG3）清除率，作为验证82Rb PET/CT使用参考方法评估肾脏灌注的第一次尝试。方法10例原发性高血压患者分2期治疗，随机给予螺内酯和安慰剂。在每个时间段结束时，每位受试者完成82Rb PET/CT扫描和[99mTc]Tc-MAG3清除研究。结果两个治疗期82Rb清除率与[99mTc]Tc-MAG3清除率呈正相关。安慰剂组和螺内酯组[99mTc] tc - mag3对82rb的清除率分别为0.83和0.86。结论82Rb清除率与[99mTc]Tc-MAG3清除率的相关性提示PET/CT测定的82Rb清除率可作为肾灌注的一个指标。[99mTc]Tc-MAG3与82Rb的间隙比表明，82Rb的萃取分数高于[99mTc]Tc-MAG3，进一步表明82Rb间隙是流量的一个估计指标。然而，需要进一步的研究来验证使用82Rb PET/CT进行流量估计。

{"title":"Renal clearance estimated by rubidium-82 positron emission tomography/computed tomography and technetium-99m-mercaptoacetyltriglycine clearance infusion technique","authors":"Stine Sundgaard Langaa, Camilla Lundgreen Duus, Marie Houmaa Vrist, Frank Holden Mose, Claire Anne Fynbo, Jørn Theil, June Anita Ejlersen, Jesper Nørgaard Bech","doi":"10.1111/cpf.70000","DOIUrl":"https://doi.org/10.1111/cpf.70000","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Although numerous techniques exist for renal blood flow (RBF) estimation, none of the methods have been implemented in routine clinical practice due to their inadequacies and burdensomeness. Previously, we evaluated rubidium-82 (<sup>82</sup>Rb) positron emission tomography/computed tomography (PET/CT) for renal perfusion determination and found strong indications of method precision and reliability. The aim of this study was to compare renal <sup>82</sup>Rb clearance with renal technetium-99m-mercaptoacetyltriglycine ([<sup>99m</sup>Tc]Tc-MAG3) clearance as a first attempt to validate <sup>82</sup>Rb PET/CT for renal perfusion estimation using a reference method.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Ten subjects with essential hypertension underwent two treatment periods, receiving spironolactone and placebo in random order. At the end of each period, each subject completed a <sup>82</sup>Rb PET/CT scan and a [<sup>99m</sup>Tc]Tc-MAG3 clearance study.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p><sup>82</sup>Rb clearance correlated positively with [<sup>99m</sup>Tc]Tc-MAG3 clearance in both treatment periods. The [<sup>99m</sup>Tc]Tc-MAG3-to-<sup>82</sup>Rb clearance ratio was 0.83 and 0.86 in the placebo and spironolactone treatment periods, respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The correlation between <sup>82</sup>Rb clearance and [<sup>99m</sup>Tc]Tc-MAG3 clearance may indicate that PET/CT determined <sup>82</sup>Rb clearance can act as an estimator of renal perfusion. The [<sup>99m</sup>Tc]Tc-MAG3-to-<sup>82</sup>Rb clearance ratios suggest that the extraction fraction of <sup>82</sup>Rb is higher than that of [<sup>99m</sup>Tc]Tc-MAG3, further suggesting <sup>82</sup>Rb clearance as an estimator of flow. However, further studies are warranted to validate use of <sup>82</sup>Rb PET/CT for flow estimation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"45 2","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cpf.70000","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143475471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Test-retest reliability of cardiopulmonary exercise test-derived metrics in individuals with COPD versus healthy controls COPD患者与健康对照者心肺运动试验衍生指标的重测可靠性

IF 1.3 4区医学 Q4 PHYSIOLOGY

Clinical Physiology and Functional Imaging

Pub Date : 2025-01-29 DOI: 10.1111/cpf.12927

Milan Mohammad, Rie S. Thomsen, Iben E. Rasmussen, Amalie B. Andersen, Jacob P. Hartmann, Ronan M. G. Berg

Background

Cardiopulmonary exercise testing (CPET) is usually considered the gold standard for assessing maximal oxygen consumption (V̇O_2max), a health and performance marker in patients with chronic obstructive pulmonary disease (COPD). Despite the widespread application of CPET, the absolute and relative test-retest reliability of CPET-derived metrics remains unexamined.

Objective

To examine and compare test-retest reliability of CPET derived metrics in individuals with COPD and healthy matched controls.

Methods

12 individuals with COPD and 12 healthy age- and sex-matched controls were included in this case-control study. Each participant completed two CPET on a bicycle ergometer on two different days. Absolute reliability was reported as smallest real difference (SRD) and relative reliability as coefficient of variance (CV) and intraclass correlation coefficients (ICC).

Main Results

SRD for peak oxygen uptake was 451.6 (267.4;1006.4) mL/min and CV was 7.8 (4.7;11.0)% in patients with COPD, whereas SRD was 244.2 (151.4;491.5) mL/min and CV was 3.0 (1.8;4.2)% in healthy controls but with no significant between group difference for SRD. CV values for all CPET derived metrics were found to be below 10%. Apart from peak workload achieved and peak minute ventilation, SRD and CV were significantly higher in COPD than in controls for all other CPET-derived metrics.

Conclusion

This study provides test-retest reliability estimates of the most widely used CPET derived metrics in individuals with COPD and healthy matched controls. Test-retest reliability for most metrics derived from CPET were found to be lower in individuals with COPD when compared to healthy controls.

背景：心肺运动试验（CPET）通常被认为是评估最大耗氧量（V * O2max）的金标准，是慢性阻塞性肺疾病（COPD）患者的健康和表现指标。尽管CPET广泛应用，但CPET衍生指标的绝对和相对重测信度仍未得到检验。目的：检验并比较慢性阻塞性肺病患者和健康对照者CPET衍生指标的重测信度。方法：12例慢性阻塞性肺病患者和12例年龄和性别匹配的健康对照纳入本病例对照研究。每个参与者在两个不同的日子里在自行车计力器上完成两个CPET。绝对信度报告为最小实差（SRD），相对信度报告为方差系数（CV）和类内相关系数（ICC）。主要结果：COPD患者的峰值摄氧量SRD为451.6 (267.4;1006.4)mL/min， CV为7.8(4.7;11.0)%，而健康对照组的SRD为244.2 (151.4;491.5)mL/min， CV为3.0(1.8;4.2)%，但SRD组间无显著差异。所有CPET衍生指标的CV值均低于10%。除了达到的峰值工作量和峰值分钟通气量外，COPD患者的SRD和CV在所有其他cpet衍生指标中均显著高于对照组。结论：本研究为COPD患者和健康对照者中最广泛使用的CPET衍生指标提供了重测信度估计。与健康对照组相比，发现COPD患者中CPET获得的大多数指标的重测信度较低。

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引用次数: 0

Blood flow restriction combined with nordic hamstring exercise does not impair endothelial function but does not increase neuromuscular activation 血流限制结合北欧腿筋运动不会损害内皮功能，但不会增加神经肌肉的激活

IF 1.3 4区医学 Q4 PHYSIOLOGY

Clinical Physiology and Functional Imaging

Pub Date : 2025-01-06 DOI: 10.1111/cpf.12926

Fuat Yuksel, Nevin Guzel, Ömer Burak Tor, Koray Akkan

Background

Optimizing hamstring exercises is crucial for injury prevention and performance. This study explored the effects of blood flow restriction (BFR) during Nordic hamstring exercises (NHE) on hamstring muscle activation and vascular function.

Methods

A randomized, single-blind study included 14 healthy, physically active males (mean age: 27.5 years). Each participant's lower extremities were randomly assigned to BFR or control groups. In the BFR group, blood flow was restricted to 60% of arterial occlusion pressure. Participants performed three sets of five NHE repetitions. Endothelial function was assessed by flow-mediated dilation (FMD) via Doppler ultrasound before and after exercise. Surface electromyography (EMG) recorded neuromuscular activation of the semitendinosus (ST) and biceps femoris (BF) muscles during exercises.

Results

FMD values showed no significant differences between BFR and control groups (F(1,13) = 0.156, p = 0.7, partial η² = 0.012). Neuromuscular activations of ST and BF muscles decreased across sets in both groups but did not differ significantly between groups (ST: F(2,26) = 1.172, p = 0.448, partial η² = 0.09; BF: F(2,26) = 1.442, p = 0.527, partial η² = 0.1).

Conclusions

BFR did not produce acute additional effects on muscle activation or endothelial function compared to standard NHE. This suggests that incorporating BFR in NHE may not enhance immediate neuromuscular or vascular responses. Further research is needed to evaluate its long-term benefits.

背景：优化腘绳肌锻炼对损伤预防和表现至关重要。本研究探讨了北欧腿筋运动（NHE）中血流量限制（BFR）对腿筋肌肉激活和血管功能的影响。方法采用随机、单盲研究方法，纳入14名健康、体力活动的男性（平均年龄27.5岁）。每个参与者的下肢被随机分配到BFR组或对照组。在BFR组，血流量被限制在动脉闭塞压的60%。参与者做了三组每组五次的NHE重复。运动前后通过多普勒超声血流介导扩张（FMD）评估内皮功能。表面肌电图（EMG）记录了运动时半腱肌（ST）和股二头肌（BF）的神经肌肉激活情况。结果FMD值BFR组与对照组比较差异无统计学意义（F(1,13) = 0.156, p = 0.7，偏η²= 0.012）。两组间ST肌和BF肌的神经肌肉激活度均下降，但组间无显著差异(ST: F(2,26) = 1.172, p = 0.448，偏η²= 0.09；BF: F(2,26) = 1.442, p = 0.527，偏η²= 0.1)。结论：与标准NHE相比，BFR不会对肌肉激活或内皮功能产生急性额外影响。这表明在NHE中加入BFR可能不会增强神经肌肉或血管的即时反应。需要进一步的研究来评估其长期效益。

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引用次数: 0

Impact of blood flow restriction intensity on pain perception and muscle recovery post-eccentric exercise 血流限制强度对偏心运动后疼痛感知和肌肉恢复的影响。

IF 1.3 4区医学 Q4 PHYSIOLOGY

Clinical Physiology and Functional Imaging

Pub Date : 2024-12-31 DOI: 10.1111/cpf.12925

Ozgur Surenkok, Gamze Aydin, Ebru Aloglu Ciftci, Kubra Kendal, Emine Atici

Background

Delayed onset muscle soreness (DOMS) is a well-established phenomenon characterized by ultrastructural muscle damage that typically develops following unfamiliar or high-intensity exercise. DOMS manifests with a constellation of symptoms, including muscle tenderness, stiffness, edema, mechanical hyperalgesia, and a reduced range of joint motion. In recent years, the application of blood flow restriction (BFR) has garnered attention for its potential impact on DOMS.

Objective

This study aimed to investigate the effects of different BFR intensities on biomechanical alterations induced by DOMS in healthy individuals.

Design and Methods

Thirty participants were split into two groups receiving either 80% or 20% BFR applied during low-intensity resistance exercise following DOMS induction. Pain perception, pressure pain threshold, muscle biometric characteristics, and strength were assessed before DOMS, after DOMS, and following BFR application at 24, 48, and 72 h.

Results

The 80% BFR group experienced faster reductions in pain perception compared to the 20% BFR group. Muscle strength recovery was also statistically faster in the 80% BFR group. No significant differences were observed between groups in muscle stiffness, flexibility, or other mechanical properties.

Conclusions

These findings suggest that BFR, particularly at higher intensities, may alleviate DOMS symptoms and accelerate muscle strength recovery. However, the lack of a control group and limitations in muscle property assessment warrant further research to definitively determine BFR's efficacy in managing DOMS.

背景：迟发性肌肉酸痛（DOMS）是一种公认的现象，其特征是肌肉超微结构损伤，通常在不熟悉或高强度运动后发生。DOMS表现为一系列症状，包括肌肉压痛、僵硬、水肿、机械性痛觉过敏和关节活动范围缩小。近年来，血流限制（BFR）的应用因其对迟发性肌肉酸痛的潜在影响而受到关注。目的：探讨不同BFR强度对健康人群迟发性肌肉酸痛引起的生物力学改变的影响。设计和方法：30名参与者被分为两组，在DOMS诱导后进行低强度阻力运动时接受80%或20% BFR。在迟发性肌肉酸痛前、迟发性肌肉酸痛后和BFR应用后24、48和72小时分别评估疼痛感觉、压力痛阈、肌肉生物特征和力量。结果：与20% BFR组相比，80% BFR组疼痛知觉的下降速度更快。肌肉力量恢复在80% BFR组也有统计学上更快。各组之间在肌肉僵硬度、柔韧性或其他机械性能方面没有观察到显著差异。结论：这些发现表明BFR，特别是在高强度时，可能减轻DOMS症状并加速肌肉力量恢复。然而，由于缺乏对照组和肌肉特性评估的局限性，需要进一步研究以明确确定BFR在治疗迟发性肌肉酸痛中的疗效。

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引用次数: 0

Positive effect of erythromycin on ineffective oesophageal motility in laryngopharyngeal reflux patients: Room for a novel treatment? 红霉素对喉咽反流患者食管运动不良的积极作用：一种新的治疗方法的空间？

IF 1.3 4区医学 Q4 PHYSIOLOGY

Clinical Physiology and Functional Imaging

Pub Date : 2024-12-29 DOI: 10.1111/cpf.12924

Fienne Sime, David Tovmassian, Gregory L. Falk

Introduction

Laryngopharyngeal reflux (LPR) management guidelines are currently derived from the management of gastroesophageal reflux disease (GORD) which has been shown to be poorly effective in controlling symptoms for these patients. Erythromycin is a macrolide antibiotic that has been used extensively as a prokinetic agent for the gastrointestinal tract. The management of LPR with prokinetics is a novel therapy being investigated with regard to its effectiveness. The purpose of this pilot study was to observe the effect of erythromycin on oesophageal motility with high resolution manometry (HRM) to establish if further study is warranted regarding its utility in management.

Methods

Consecutive patients were retrospectively identified from a prospectively maintained database at a single centre of patients with findings suggestive of LPR who had also undergone HRM. These patients all received lifestyle modification and erythromycin 250 mg BD with repeat HRM after 6 weeks of therapy.

Results

16 patients met inclusion criteria. Mean age was 56.2 ± 14.9. Mean ineffective swallows were 54.38% ± 41.3% compared with 34.4% ± 35.2% pre and post-erythromycin therapy (p = 0.018). Mean distal contractile integral at baseline was 793.61 ± 854.96 mmHg at baseline increasing to 1347 ± 1094.73 mmHg after erythromycin therapy (p = 0.013). IRP also showed improvement from 8.99 ± 7.58 increasing to 10.93 ± 7.9 mmHg (p = 0.045). Subgroup analysis of patients with ineffective oesophageal motility reinforced above findings as well as increase in the amount of ‘normal’ peristalsis.

Conclusion

This pilot study shows early evidence that erythromycin improves oesophageal motility. Further study is warranted to explore these findings in more detail.

简介：喉咽反流（LPR）管理指南目前来自胃食管反流病（GORD）的管理，该疾病已被证明在控制这些患者的症状方面效果不佳。红霉素是一种大环内酯类抗生素，被广泛用作胃肠道的促动力剂。用促生治疗LPR是一种新的治疗方法，目前正在研究其有效性。本初步研究的目的是用高分辨率测压仪（HRM）观察红霉素对食管运动的影响，以确定其在治疗中的应用是否值得进一步研究。方法：从前瞻性维护的单一中心数据库中回顾性地确定了连续的患者，这些患者的发现表明LPR也接受了HRM。这些患者在治疗6周后均接受生活方式改变和红霉素250mg BD，并重复HRM。结果：16例患者符合纳入标准。平均年龄56.2±14.9岁。红霉素治疗前后平均无效吞咽率为54.38%±41.3%，而红霉素治疗前后平均无效吞咽率为34.4%±35.2% （p = 0.018）。平均远端收缩积分基线时为793.61±854.96 mmHg，红霉素治疗后增加到1347±1094.73 mmHg （p = 0.013）。IRP也从8.99±7.58 mmHg上升到10.93±7.9 mmHg （p = 0.045）。亚组分析食道运动无效的患者加强了上述发现以及“正常”蠕动量的增加。结论：本初步研究显示红霉素改善食管运动的早期证据。有必要进一步研究以更详细地探讨这些发现。

{"title":"Positive effect of erythromycin on ineffective oesophageal motility in laryngopharyngeal reflux patients: Room for a novel treatment?","authors":"Fienne Sime, David Tovmassian, Gregory L. Falk","doi":"10.1111/cpf.12924","DOIUrl":"10.1111/cpf.12924","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Laryngopharyngeal reflux (LPR) management guidelines are currently derived from the management of gastroesophageal reflux disease (GORD) which has been shown to be poorly effective in controlling symptoms for these patients. Erythromycin is a macrolide antibiotic that has been used extensively as a prokinetic agent for the gastrointestinal tract. The management of LPR with prokinetics is a novel therapy being investigated with regard to its effectiveness. The purpose of this pilot study was to observe the effect of erythromycin on oesophageal motility with high resolution manometry (HRM) to establish if further study is warranted regarding its utility in management.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Consecutive patients were retrospectively identified from a prospectively maintained database at a single centre of patients with findings suggestive of LPR who had also undergone HRM. These patients all received lifestyle modification and erythromycin 250 mg BD with repeat HRM after 6 weeks of therapy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>16 patients met inclusion criteria. Mean age was 56.2 ± 14.9. Mean ineffective swallows were 54.38% ± 41.3% compared with 34.4% ± 35.2% pre and post-erythromycin therapy (<i>p</i> = 0.018). Mean distal contractile integral at baseline was 793.61 ± 854.96 mmHg at baseline increasing to 1347 ± 1094.73 mmHg after erythromycin therapy (<i>p</i> = 0.013). IRP also showed improvement from 8.99 ± 7.58 increasing to 10.93 ± 7.9 mmHg (<i>p</i> = 0.045). Subgroup analysis of patients with ineffective oesophageal motility reinforced above findings as well as increase in the amount of ‘normal’ peristalsis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This pilot study shows early evidence that erythromycin improves oesophageal motility. Further study is warranted to explore these findings in more detail.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"45 1","pages":""},"PeriodicalIF":1.3,"publicationDate":"2024-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142902797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The value of semiquantitative analysis of [99mTc]MDP SPECT/CT in localizing responsible lesions for suspected fresh osteoporotic vertebral compression fractures in patients with contraindications to MRI [99mTc]MDP SPECT/CT半定量分析在MRI禁忌症患者疑似新鲜骨质疏松性椎体压缩性骨折的责任病灶定位中的价值

IF 1.3 4区医学 Q4 PHYSIOLOGY

Clinical Physiology and Functional Imaging

Pub Date : 2024-12-26 DOI: 10.1111/cpf.12923

Sheng Shi, Hai-Dong Cai, Gai-Xia Lu, Li-Guo Zhang, Shuang Zheng, Shi-Sheng He

Purpose

The aim of this study was to evaluate the effectiveness of single-photon emission computed tomography/computed tomography (SPECT/CT) in detecting and localizing the causative vertebra in cases of suspected fresh osteoporotic vertebral compression fractures (OVCFs) in patients with contraindications to MRI.

Methods

A total of 21 patients with severe back pain with 31 suspected OVCF segments and contraindications to MRI were initially identified through radiographs and the back pain-inducing test (BPIT). The responsible vertebral bodies were determined using [^99mTc]MDP SPECT/CT before percutaneous vertebroplasty (PVP). Clinical outcomes and radiographic parameters, including basic demographics, injury duration, focal kyphosis (FK), loss of vertebral height (LVH), and relative intensity values (RIVs) for target and nontarget segments in the SPECT/CT were measured.

Results

SPECT/CT identified 14 old and 26 fresh OVCFs. Of these, 18 patients with 26 fresh OVCF segments underwent PVP, and achieved satisfactory outcomes. Significant differences were observed in the RIV, FK, and LVH values between the fresh and old OCVF groups (all p < 0.05). RIVs showed a significant negative correlation with injury duration (r = −0.57, p < 0.05), and a positive correlation with LVH (r = 0.43, p < 0.05). Multiple linear regression analysis confirmed that injury duration was an independent predictor of RIVs (p < 0.05).

Conclusion

SPECT/CT is useful for detecting and differentiating fresh fractures from old fractures in patients having OVCF who cannot undergo MRI after BPIT validation, allowing these patients to achieve excellent clinical outcomes following PVP. The RIV serves as a valuable parameter for assessing the duration of fresh versus old OVCFs.

Trial Registration

ChiCTR, ChiCTR 2300077570. Retrospectively registered, http://www.chictr.org.cn/showproj.html?proj=206192.

目的：本研究的目的是评估单光子发射计算机断层扫描/计算机断层扫描（SPECT/CT）在MRI禁忌症患者疑似新鲜骨质疏松性椎体压缩性骨折（OVCFs）病例中检测和定位病因椎体的有效性。方法：通过x线片和腰痛诱发试验（BPIT）初步确定21例重度腰痛患者，31个疑似OVCF节段，MRI禁忌症。经皮椎体成形术（PVP）前使用[99mTc]MDP SPECT/CT确定责任椎体。临床结果和影像学参数，包括基本人口统计学、损伤持续时间、局灶性后凸（FK）、椎体高度损失（LVH）以及靶节段和非靶节段在SPECT/CT上的相对强度值（RIVs）。结果：SPECT/CT检出14例旧OVCFs， 26例新OVCFs。其中，18例26个新鲜OVCF节段患者接受了PVP治疗，并取得了满意的结果。新旧OCVF组RIV、FK、LVH值差异均有统计学意义（p < 0.05）。RIVs与损伤持续时间呈显著负相关（r = -0.57, p < 0.05），与LVH呈正相关（r = 0.43, p < 0.05）。多元线性回归分析证实，损伤时间是RIVs的独立预测因子（p < 0.05）。结论：对于BPIT验证后无法接受MRI的OVCF患者，SPECT/CT可用于检测和区分新骨折和旧骨折，使这些患者在PVP后获得良好的临床结果。RIV是评估新鲜OVCFs与旧OVCFs持续时间的一个有价值的参数。试验注册：ChiCTR， ChiCTR 2300077570。追溯登记，http://www.chictr.org.cn/showproj.html?proj=206192。

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引用次数: 0