Clinical Physiology and Functional Imaging最新文献_第10页

A preliminary study of changes in carotid artery elasticity in type 2 diabetes mellitus 2型糖尿病患者颈动脉弹性变化的初步研究

IF 1.8 4区医学 Q3 Medicine

Clinical Physiology and Functional Imaging

Pub Date : 2022-12-30 DOI: 10.1111/cpf.12808

Chun-xiang Jin, Jing Tian, Hui-hui Yang, Yu He

Background

Carotid stiffening is found to be present in patients with type 2 diabetes mellitus (T2DM) together with endothelial dysfunction and it remains unclear about the role of carotid elasticity in the development of diabetic vascular damage. The aim of the study was to investigate changes and significance of carotid artery elasticity in diabetic patients with or without microvascular complications using velocity vector imaging (VVI) analysis.

Methods

Fifty participants were enrolled and divided into health Control group, the uncomplicated DM (uDM) group and the complicated DM (cDM) group. All of them underwent carotid ultrasound examinations. VVI was used to evaluate the common carotid artery (CCA) elasticity and intima-media thickness (IMT) was also measured. Flow-mediated dilation (FMD) was performed to detect the vascular endothelial function. Then differences and correlations of variables between three groups were compared and analyzed.

Results

CCA elasticity measured by VVI decreased significantly between three groups (p < 0.05), while FMD decreased significantly only in cDM group (p < 0.01) and only IMT in cDM group was significantly thicker than that of Control group (p < 0.05). Representative VVI variables were independently, negatively related to the known duration and microalbuminuria (p < 0.05). All VVI variables were significantly correlated with FMD (0.5 ≤ |r | <0.8, p < 0.001), and just a small part of VVI variables were significantly correlated with IMT (0.3 ≤ |r | <0.5, p < 0.05).

Conclusion

Compared with FMD, CCA elasticity measured by VVI showed more obvious changes in diabetic patients with different levels of vascular damage and may be considered as an alternative indicator in evaluating arterial status of T2DM.

研究背景:2型糖尿病(T2DM)患者颈动脉硬化并伴有内皮功能障碍，颈动脉弹性在糖尿病血管损伤发展中的作用尚不清楚。本研究的目的是利用速度矢量成像(VVI)分析糖尿病患者颈动脉弹性的变化及其意义。方法将50例糖尿病患者分为健康对照组、单纯糖尿病(uDM)组和复杂糖尿病(cDM)组。所有患者均行颈动脉超声检查。采用VVI评估颈总动脉(CCA)弹性，测量颈中膜厚度(IMT)。血流介导扩张(FMD)检测血管内皮功能。然后比较分析三组间各变量的差异及相关性。结果三组间VVI测量的CCA弹性均显著降低(p < 0.05)， FMD仅cDM组显著降低(p < 0.01)， IMT仅cDM组显著厚于对照组(p < 0.05)。代表性VVI变量与已知持续时间和微量白蛋白尿呈独立负相关(p < 0.05)。所有VVI变量均与FMD显著相关(0.5≤|r | <0.8, p < 0.001)，只有小部分VVI变量与IMT显著相关(0.3≤|r | <0.5, p < 0.05)。结论与FMD相比，VVI测量的CCA弹性在不同程度血管损伤的糖尿病患者中变化更明显，可作为评估T2DM动脉状态的替代指标。

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引用次数: 0

Quantifying leg muscle deoxygenation during incremental cycling in hypoxemic patients with fibrotic interstitial lung disease 量化低氧血症合并纤维化间质性肺疾病患者在增量循环过程中的腿部肌肉脱氧

IF 1.8 4区医学 Q3 Medicine

Clinical Physiology and Functional Imaging

Pub Date : 2022-12-29 DOI: 10.1111/cpf.12809

Mathieu Marillier, Anne-Catherine Bernard, Samuel Verges, Onofre Moran-Mendoza, J. Alberto Neder

Background

Hypoxaemia and cardiocirculatory abnormalities may impair muscle oxygen (O₂) delivery relative to O₂ requirements thereby increasing the rate of O₂ extraction during incremental exercise in fibrotic interstitial lung disease (f-ILD). Using changes in deoxyhaemoglobin concentration ([HHb]) by near-infrared spectroscopy (NIRS) as a proxy of O₂ extraction, we investigated whether a simplified (double-linear) approach, previously tested in heart failure, would provide useful estimates of muscle deoxygenation in f-ILD.

Methods

A total of 25 patients (23 men, 72 ± 8 years; 20 with idiopathic pulmonary fibrosis, lung diffusing capacity for carbon monoxide = 44 ± 11% predicted) and 12 age- and sex-matched healthy controls performed incremental cycling to symptom limitation. Changes in vastus lateralis [HHb] assessed by NIRS were analysed in relation to work rate (WR) and O₂ uptake throughout the exercise.

Results

Patients showed lower exercise capacity than controls (e.g., peak WR = 67 ± 18% vs. 105 ± 20% predicted, respectively; p < 0.001). The [HHb] response profile was typically S-shaped, presenting three distinct phases. Exacerbated muscle deoxygenation in patients versus controls was evidenced by: (i) a steeper mid-exercise [HHb]-WR slope (0.30 ± 0.22 vs. 0.11 ± 0.08 μmol/W; p = 0.008) (Phase 2), and (ii) a larger late-exercise increase in [HHb] (p = 0.002) (Phase 3). Steeper [HHb]-WR slope was associated with lower peak WR (r = –0.70) and greater leg discomfort (r = 0.77; p < 0.001) in f-ILD.

Conclusion

This practical approach to interpreting [HHb] during incremental exercise might prove useful to determine the severity of muscle deoxygenation and the potential effects of interventions thereof in hypoxemic patients with f-ILD.

背景:在纤维化间质性肺疾病(f-ILD)患者中，低氧血症和心脏循环异常可能损害相对于氧气需求的肌肉氧气(O2)输送，从而增加增量运动期间的氧气提取率。利用近红外光谱(NIRS)的脱氧血红蛋白浓度([hbb])的变化作为O2提取的代理，我们研究了一种简化的(双线性)方法，以前在心力衰竭中测试过，是否可以提供f-ILD肌肉脱氧的有用估计。方法25例患者(男性23例，72±8岁;20例特发性肺纤维化患者(预测肺一氧化碳弥散量= 44±11%)和12例年龄和性别匹配的健康对照者进行了渐进式循环至症状限制。通过近红外光谱(NIRS)评估股外侧肌[hbb]的变化，分析其与整个运动过程中的工作速率(WR)和氧气摄取的关系。结果患者的运动能力低于对照组(例如，峰值WR分别为67±18%和105±20%;p < 0.001)。[hbb]响应曲线呈典型的s型，呈现三个不同的阶段。与对照组相比，患者肌肉缺氧加剧的证据是:(i)运动中期[hbb]-WR斜率更陡(0.30±0.22 vs 0.11±0.08 μmol/W);p = 0.008)(第二阶段)，(ii)运动后[hbb]增加较多(p = 0.002)(第三阶段)。[hbb]-WR斜率越陡，峰值WR越低(r = -0.70)，腿部不适程度越高(r = 0.77;p < 0.001)。结论:这种在增量运动中解释[hbb]的实用方法可能有助于确定低氧血症f-ILD患者肌肉缺氧的严重程度及其干预措施的潜在影响。

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引用次数: 1

Safety and feasibility of cardiopulmonary exercise testing in head and neck cancer survivors 头颈癌幸存者心肺运动试验的安全性和可行性

IF 1.8 4区医学 Q3 Medicine

Clinical Physiology and Functional Imaging

Pub Date : 2022-12-19 DOI: 10.1111/cpf.12807

Adrian W. Midgley, Andrew R. Levy, Felipe A. Cunha, Angela Key, Joanne M. Patterson, Simon N. Rogers

Purpose

Assess safety and feasibility of the cardiopulmonary exercise test (CPET) for evaluating head and neck cancer (HaNC) survivors. Also compare their cardiorespiratory fitness to age and sex-matched norms and establish current physical activity levels.

Methods

Fifty HaNC survivors [29 male; mean (SD) age, 62 (8) years], who had completed treatment up to 1 year previously, were recruited. Participants performed a CPET on a cycle ergometer to symptom-limited tolerance. Participants completed a questionnaire to report contributory factors they perceived as influencing test termination. Physical activity levels were determined using a self-reported physical activity questionnaire.

Results

Three participants did not complete the CPET because (1) poor fitting mouthpiece and naso-oral mask due to facial disfiguration from surgery; (2) knee pain elicited by cycling; and (3) early CPET termination due to electrocardiogram artefacts. Participants reached a mean peak oxygen uptake that was 34% lower than predicted and the mean (SD) CPET duration of 7:52 (2:29) min:s was significantly lower than the target test duration of 10 min (p < 0.001). Leg muscle aches and/or breathing discomfort were major contributory factors influencing test termination for 78% of participants, compared to 13% for dry mouth/throat and/or drainage in the mouth/throat. No major adverse events occurred. Participants were categorised as 26% active, 8% moderately active, and 66% insufficiently active.

Conclusion

These preliminary data suggest the CPET appears safe and feasible for most HaNC survivors when strict exclusion criteria are applied; however, low levels of cardiorespiratory fitness should be considered when calculating an appropriate ramp rate.

目的评估心肺运动试验(CPET)评估头颈癌(HaNC)幸存者的安全性和可行性。还要将他们的心肺健康与年龄和性别匹配的标准进行比较，并建立当前的身体活动水平。方法50例HaNC幸存者[男性29例;平均(SD)年龄为62(8)岁，在1年前完成治疗。参与者在循环计力器上进行CPET以达到症状限制耐受性。参与者完成一份调查问卷，报告他们认为影响试验终止的因素。使用自我报告的身体活动问卷来确定身体活动水平。结果3例患者未完成CPET检查的原因是:(1)手术造成的面部畸形导致牙套和鼻口口罩贴合不良;(2)骑行引起的膝关节疼痛;(3)由于心电图伪影导致的CPET早期终止。参与者达到的平均峰值摄氧量比预测低34%，平均(SD) CPET持续时间为7:52(2:29)分:秒，显著低于目标测试持续时间10分钟(p < 0.001)。腿部肌肉疼痛和/或呼吸不适是影响测试终止的主要因素，对78%的参与者来说，相比之下，13%的参与者是因为口/喉咙干燥和/或口/喉咙引流。未发生重大不良事件。参与者分为26%运动，8%适度运动，66%运动不足。结论在严格的排除标准下，CPET对大多数HaNC幸存者是安全可行的;然而，在计算适当的斜坡速率时，应考虑低水平的心肺健康。

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引用次数: 1

Left atrial contraction strain during a Valsalva manoeuvre: A study in healthy humans 左心房收缩应变在Valsalva演习:一项研究在健康的人

IF 1.8 4区医学 Q3 Medicine

Clinical Physiology and Functional Imaging

Pub Date : 2022-12-19 DOI: 10.1111/cpf.12806

Peter Gottfridsson, Lucy Law, Roman A'roch, Tomi Myrberg, Magnus Hultin, Per Lindqvist, Michael Haney

Background

Cardiac mechanics are influenced by loading conditions as well as sympathetic tone. Left atrial (LA) contractile function assessed by two-dimensional (2D) strain has been described in the setting of controlled preload alterations; however, studies show conflicting findings about change or direction of change. We hypothesized that the controlled preload reduction and the sympathetic nervous system activation that occurs during a standardized Valsalva manoeuvre would bring about a change in LA contraction strain.

Methods

Healthy young adults of both sexes were recruited. Transthoracic echocardiographic ultrasound images were collected before and during a Valsalva manoeuvre. Standard imaging windows for LA strain assessment were used and the images were copied and stored for later offline analysis. These were assessed for adequate atrial wall visualization in 2D strain assessment. Paired comparisons were carried out using Student's T test.

Result

Thirty-eight participants were included and there were 22 complete studies with paired pre- and during Valsalva manoeuvre. LA contraction strain at baseline was 10.5 ± 2.8% (standard deviation) and during the Valsalva manoeuvre 10.6 ± 4.6%, p = 0.86.

Conclusion

The Valsalva manoeuvre, a combination of preload reduction and sympathetic nervous system activation, seems not to be associated with a change in LA contraction strain in healthy young individuals. LA contraction strain should be interpreted in the context of both atrial loading conditions and prevailing autonomic nervous system activity.

心脏力学受负荷条件和交感神经张力的影响。在控制预负荷改变的情况下，通过二维(2D)应变评估的左心房(LA)收缩功能已被描述;然而，研究显示了关于变化或变化方向的相互矛盾的发现。我们假设，在标准化Valsalva动作中发生的可控预负荷减少和交感神经系统激活将导致LA收缩应变的变化。方法招募健康的男女青年。在Valsalva手术之前和期间收集经胸超声心动图超声图像。使用用于LA应变评估的标准成像窗口，复制并存储图像以供以后的离线分析。在二维应变评估中评估这些房壁是否足够可视化。采用Student’s T检验进行配对比较。结果共纳入38例受试者，其中22例完成了瓦尔萨尔瓦运动前后的配对研究。基线时LA收缩应变为10.5±2.8%(标准差)，Valsalva运动时为10.6±4.6%，p = 0.86。结论:Valsalva动作，预负荷减少和交感神经系统激活的结合，似乎与健康年轻人LA收缩应变的变化无关。LA收缩应变应在心房负荷条件和普遍的自主神经系统活动的背景下解释。

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引用次数: 1

Feasibility and early effects of bed-cycling eccentric training: Potential clinical applications 床上循环偏心训练的可行性和早期效果:潜在的临床应用

IF 1.8 4区医学 Q3 Medicine

Clinical Physiology and Functional Imaging

Pub Date : 2022-12-11 DOI: 10.1111/cpf.12805

Laura Pavlin, Florian Fernandez, Rauhiti Lowgreen, Isabelle Ohresser, Jean-Paul Cristol, Cécile Turc-Baron, Henri Bernardi, Robin Candau

Purpose

This study aimed to evaluate feasibility and early effects of moderate intensity bed-cycling eccentric training on healthy individuals, and establish whether this training modality could be implemented into bedridden patients' routine care.

Methods

Longitudinal study with prepost exercise intervention measurements. The development of a bed-adapted eccentric ergometer allowed to conduct five training sessions during 3 weeks at increasing intensity on 11 healthy individuals. Force-speed relationship, maximal voluntary knee extension force and neural activation of subjects were evaluated before and after the programme.

Results

Five training sessions were sufficient to decrease the rate of perceived exertion whereas eccentric power output increased (+40%). After training, maximal voluntary isometric contraction force measured during knee extension had significantly improved in all subjects, with a mean increase of 17%. Maximal cycling power was also significantly higher (+7%) after the training programme.

Conclusion

Taken together, these results show that moderate load eccentric bed cycling (i) was feasible and efficient, (ii) did not generate excessive individual perception of effort during exercise nor develop major muscular or joint pain after training and (iii) allowed early force and power gains in healthy subjects.

目的探讨中强度卧床偏心训练对健康个体的可行性及早期效果，探讨该训练模式是否可应用于卧床病人的日常护理。方法采用运动前干预措施进行纵向研究。一种适用于床的偏心测力器的开发允许在3周内对11名健康个体进行5次训练，强度不断增加。对训练前后的力-速度关系、膝关节最大自主伸直力和神经激活度进行评价。结果5次训练足以降低感知用力率，而偏心功率输出增加(+40%)。训练后，所有受试者在膝关节伸展时测量的最大自主等距收缩力均有显著改善，平均增加17%。训练计划后，最大循环功率也显著提高(+7%)。综上所述，这些结果表明，适度负荷的偏心床骑行(i)是可行和有效的，(ii)在运动过程中不会产生过度的个人努力感，也不会在训练后产生主要的肌肉或关节疼痛，(iii)允许健康受试者早期获得力量和力量。

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引用次数: 0

T1 mapping and reduced field-of-view DWI at 3.0 T MRI for differentiation of thyroid papillary carcinoma from nodular goiter 3.0 T MRI T1定位和缩小视野DWI鉴别甲状腺乳头状癌与结节性甲状腺肿

IF 1.8 4区医学 Q3 Medicine

Clinical Physiology and Functional Imaging

Pub Date : 2022-11-28 DOI: 10.1111/cpf.12803

Letian Yuan, Peng Zhao, Xiangtao Lin, Tianyi Yu, Ruiyuan Diao, Guqing Ning

Background

Reduced field-of-view diffusion-weighted imaging (rFOV-DWI) could be proved to quantitatively identify papillary thyroid carcinoma (PTC) and there is no literature regarding the use of T1 mapping to distinguish nodular goiter (NG) from PTC.

Purpose

To compare T1 mapping with rFOV-DWI in differentiating NG and PTC.

Study Type

Prospective study.

Populations

Ninety-five hospitalized patients with thyroid nodules were included in the research.

Sequence

All subjects underwent T1-weighted imaging, T2-weighted imaging, rFOV-DWI and T1-mapping sequences.

Assessment

The apparent diffusion coefficient (ADC) and T1 values of each thyroid nodule were measured, respectively. According to pathological results, the thyroid nodules were divided into two groups: Group 1 (NG) and Group 2 (PTC).

Statistical Tests

An independent sample t test was used to evaluate the differences of ADC and T1 between the two groups. The receiver operating characteristic (ROC) curve was used to analyze the diagnostic efficiency of T1, ADC, Thyroid Imaging Reporting and Data System (TI-RADS) and T1 and ADC.

Results

The T1 and ADC values of nodular goiter were both higher than those of PTC (p < 0.05). The area under the ROC curve (AUC) values of T1 and ADC were significantly higher than that of T1 or ADC alone (p < 0.05). The AUC value of T1 and ADC was as same as that of TI-RADS.

Conclusion

The combination of T1 mapping and rFOV-DWI could effectively differentiate NG from PTC. And it has at least the same diagnostic value as the ultrasound-based TI-RADS classification.

缩小视场弥散加权成像(rFOV-DWI)可以定量识别甲状腺乳头状癌(PTC)，但使用T1定位区分结节性甲状腺肿(NG)和PTC尚无文献报道。目的比较T1显像与rFOV-DWI对NG和PTC的鉴别价值。研究类型前瞻性研究。研究对象包括95名甲状腺结节住院患者。所有受试者均行t1加权成像、t2加权成像、rFOV-DWI和t1定位序列。分别测定各甲状腺结节的表观扩散系数(ADC)和T1值。根据病理结果将甲状腺结节分为两组:1组(NG)和2组(PTC)。采用独立样本t检验评价两组间ADC和T1的差异。采用受试者工作特征(ROC)曲线分析T1、ADC、甲状腺影像报告与数据系统(TI-RADS)和T1、ADC的诊断效率。结果结节性甲状腺肿的T1和ADC值均高于PTC (p < 0.05)。T1和ADC组的ROC曲线下面积(AUC)值显著高于单独使用T1或ADC组(p < 0.05)。T1和ADC的AUC值与TI-RADS相同。结论结合T1作图和rFOV-DWI可有效鉴别NG和PTC。至少与基于超声的TI-RADS分类具有相同的诊断价值。

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引用次数: 1

Comparability of childhood blood pressure measurements with two different devices 两种不同装置测量儿童血压的可比性

IF 1.8 4区医学 Q3 Medicine

Clinical Physiology and Functional Imaging

Pub Date : 2022-11-28 DOI: 10.1111/cpf.12802

Lukas Streese, Christoph Hauser, Henner Hanssen

Introduction

Higher blood pressure levels are associated with vascular dysfunction as early as childhood. Here, we aim to compare two blood pressure devices for use in childhood populations within a school setting to screen for elevated blood pressure in children.

Methods

Systolic and diastolic blood pressure, mean arteriolar pressure (MAP) as well as heart rate (HR) were measured with the validated Oscillomate 9002 and Mindray VS-900 in 82 randomly selected children between 10 and 12 years taking part in the EXAMIN YOUTH study in 2020. Measurements were performed after 5 min at rest in a sitting position in the school environment.

Results

Both devices showed strong correlations for systolic (r = 0.62, t[80] = 7, p < 0.001) and diastolic blood pressure (r = 0.73, t[80] = 9.52, p < 0.001), MAP (r = 0.75, t[80] = 10.22, p < 0.001) and HR (r = 0.89, t[79] = 17.77, p < 0.001). There was no evidence for a statistically significant difference of both devices for systolic (110 ± 9 mmHg vs. 111 ± 9 mmHg, p = 0.574), diastolic blood pressure (67 ± 9 mmHg vs. 66 ± 9 mmHg, p = 0.301) as well as MAP (81 ± 8 mmHg vs. 80 ± 8 mmHg, p = 0.400) and HR (83 ± 12 BPM vs. 83 ± 11 BPM, p = 0.994).

Discussion

Both devices, the older Oscillomate 9002 and the current Mindray VS-900 showed good agreement for the measurement of blood pressure in school children. It therefore appears to be feasible to measure childhood blood pressure with either device or replace one device with another in prospective long-term studies or screening programmes as long as both are validated for use in children.

高血压早在儿童时期就与血管功能障碍有关。在这里，我们的目的是比较两种血压设备用于儿童人群在学校设置筛选儿童血压升高。方法:在2020年的EXAMIN YOUTH研究中，随机选择82名10 - 12岁的儿童，使用经过验证的Oscillomate 9002和Mindray VS-900测量收缩压、舒张压、平均小动脉压(MAP)和心率(HR)。在学校环境中静坐休息5分钟后进行测量。结果两种装置在收缩压(r = 0.62, t[80] = 7, p < 0.001)、舒张压(r = 0.73, t[80] = 9.52, p < 0.001)、MAP (r = 0.75, t[80] = 10.22, p < 0.001)和HR (r = 0.89, t[79] = 17.77, p < 0.001)方面均表现出较强的相关性。两种装置在收缩压(110±9 mmHg vs 111±9 mmHg, p = 0.574)、舒张压(67±9 mmHg vs 66±9 mmHg, p = 0.301)、MAP(81±8 mmHg vs 80±8 mmHg, p = 0.400)和心率(83±12 BPM vs 83±11 BPM, p = 0.994)方面无统计学差异。这两种设备，旧的振荡9002和当前的迈瑞VS-900在测量学龄儿童血压方面表现出良好的一致性。因此，在前瞻性长期研究或筛查计划中，只要两种设备都被证实适用于儿童，用其中一种设备测量儿童血压或用另一种设备替换一种设备似乎是可行的。

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引用次数: 2

Effects of different exercises on respiratory parameters: A randomized controlled trial 不同运动对呼吸参数的影响:一项随机对照试验

IF 1.8 4区医学 Q3 Medicine

Clinical Physiology and Functional Imaging

Pub Date : 2022-11-26 DOI: 10.1111/cpf.12804

Hasan Gercek, Bayram S. Unuvar, Kamil Yilmaz, Ozlem Akkoyun Sert, Sinan Bagcaci

This study was designed to compare the effects of core stabilisation (CS) and auxiliary respiratory muscle strengthening exercises on oxygen consumption and respiratory parameters. A total of 51 participants were divided into three groups with block randomization method according to age and gender: CS Group (n = 17), Auxiliary Respiratory Muscles Exercise (ARM) Group (n = 17) and Control (C) Group (n = 17). Maximum oxygen uptake (VO₂max), first second of forced expiration (FEV1)/Forced vital capacity (FVC) and maximal voluntary ventilation (MVV) values were evaluated before and after the study. CS and ARM strengthening exercises were applied 3 days a week for 6 weeks. The increase in the FEV1/VC values was higher in the CS and ARM groups than in the C group (p < 0.05), whereas no statistically significant difference was observed between the ARM and CS groups (p < 0.05). There was no statistically significant difference between the groups in terms of VO₂max values before and after the study (p > 0.05). The increase in the MVV values was higher in the CS and ARM groups than in the C group (p < 0.05), whereas no statistically significant difference was observed between the ARM and CS groups (p > 0.05). CS and ARM exercises had positive effects on FEV1/FVC and MVV.

本研究旨在比较核心稳定(CS)和辅助呼吸肌强化训练对耗氧量和呼吸参数的影响。51例受试者按年龄和性别采用分组随机法分为3组:CS组(n = 17)、辅助呼吸肌运动(ARM)组(n = 17)和对照组(C)组(n = 17)。在研究前后评估最大摄氧量(VO2max)、强迫呼气第一秒(FEV1)/强迫肺活量(FVC)和最大自主通气(MVV)值。CS和ARM强化训练每周3天，连续6周。CS组和ARM组FEV1/VC值的升高高于C组(p < 0.05)，而ARM组和CS组间差异无统计学意义(p < 0.05)。研究前后两组VO2max值比较，差异无统计学意义(p > 0.05)。CS组和ARM组MVV值的升高高于C组(p < 0.05)，而ARM组和CS组间差异无统计学意义(p < 0.05)。CS和ARM运动对FEV1/FVC和MVV均有积极影响。

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引用次数: 0

Detailed investigation of multiple resting cardiovascular parameters in relation to physical fitness 多种静息心血管参数与体能关系的详细研究

IF 1.8 4区医学 Q3 Medicine

Clinical Physiology and Functional Imaging

Pub Date : 2022-11-21 DOI: 10.1111/cpf.12800

Lars Lind, Karl Michaëlsson

Objective

Maximal oxygen consumption at an exercise test (VO₂-max) is a commonly used marker of physical fitness. In the present study, we aimed to find independent clinical predictors of VO₂-max by use of multiple measurements of cardiac, respiratory and vascular variables collected while resting.

Methods

In the Prospective study of Obesity, Energy and Metabolism (POEM), 420 subjects aged 50 years were investigated regarding endothelial function, arterial compliance, heart rate variability, arterial blood flow and atherosclerosis, left ventricular structure and function, lung function, multiple blood pressure measurements, lifestyle habits, body composition and in addition a maximal bicycle exercise test with gas exchange (VO₂ and VCO₂).

Results

When VO₂-max (indexed for lean mass) was used as the dependent variable and the 84 hemodynamic or metabolic variables were used as independent variables in separate sex-adjusted models, 15 variables showed associations with p < 0.00064 (Bonferroni-adjusted). Eight independent variables explained 21% of the variance in VO₂-max. Current smoking and pulse wave velocity (PWV) were the two major determinants of VO₂-max (explaining each 7% and 3% of the variance; p < 0.0001 and p = 0.008, respectively). They were in order followed by vital capacity, fat mass, pulse pressure, and high-density lipoprotein (HDL)-cholesterol. The relationships were inverse for all these variables, except for vital capacity and HDL.

Conclusion

Several metabolic, cardiac, respiratory and vascular variables measured at rest explained together with smoking 21% of the variation in VO₂-max in middle-aged individuals. Of those variables, smoking and PWV were the most important.

目的运动测试最大耗氧量（VO2max）是一种常用的身体素质指标。在本研究中，我们旨在通过对静息时收集的心脏、呼吸和血管变量进行多次测量，找到VO2 max的独立临床预测因素。方法在肥胖、能量和代谢前瞻性研究（POEM）中，对420名50岁的受试者进行了内皮功能、动脉顺应性、心率变异性、动脉血流量和动脉粥样硬化、左心室结构和功能、肺功能、多种血压测量、生活习惯、，身体成分，以及具有气体交换（VO2和VCO2）的最大自行车运动测试。结果在单独的性别调整模型中，当VO2 max（瘦体重指数）作为因变量，84个血液动力学或代谢变量作为自变量时，15个变量与p <； 0.00064（Bonferroni调整）。八个自变量解释了VO2-max中21%的方差。当前吸烟和脉搏波速度（PWV）是VO2最大值的两个主要决定因素（分别解释7%和3%的方差；p <； 0.0001和p = 分别为0.008）。依次为肺活量、脂肪量、脉压和高密度脂蛋白胆固醇。除肺活量和高密度脂蛋白外，所有这些变量的关系都是相反的。结论休息时测量的几个代谢、心脏、呼吸和血管变量与吸烟一起解释了中年人VO2 max变化的21%。在这些变量中，吸烟和PWV是最重要的。

{"title":"Detailed investigation of multiple resting cardiovascular parameters in relation to physical fitness","authors":"Lars Lind, Karl Michaëlsson","doi":"10.1111/cpf.12800","DOIUrl":"10.1111/cpf.12800","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Maximal oxygen consumption at an exercise test (VO<sub>2</sub>-max) is a commonly used marker of physical fitness. In the present study, we aimed to find independent clinical predictors of VO<sub>2</sub>-max by use of multiple measurements of cardiac, respiratory and vascular variables collected while resting.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In the Prospective study of Obesity, Energy and Metabolism (POEM), 420 subjects aged 50 years were investigated regarding endothelial function, arterial compliance, heart rate variability, arterial blood flow and atherosclerosis, left ventricular structure and function, lung function, multiple blood pressure measurements, lifestyle habits, body composition and in addition a maximal bicycle exercise test with gas exchange (VO<sub>2</sub> and VCO<sub>2</sub>).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>When VO<sub>2</sub>-max (indexed for lean mass) was used as the dependent variable and the 84 hemodynamic or metabolic variables were used as independent variables in separate sex-adjusted models, 15 variables showed associations with <i>p</i> < 0.00064 (Bonferroni-adjusted). Eight independent variables explained 21% of the variance in VO<sub>2</sub>-max. Current smoking and pulse wave velocity (PWV) were the two major determinants of VO<sub>2</sub>-max (explaining each 7% and 3% of the variance; <i>p</i> < 0.0001 and <i>p</i> = 0.008, respectively). They were in order followed by vital capacity, fat mass, pulse pressure, and high-density lipoprotein (HDL)-cholesterol. The relationships were inverse for all these variables, except for vital capacity and HDL.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Several metabolic, cardiac, respiratory and vascular variables measured at rest explained together with smoking 21% of the variation in VO<sub>2</sub>-max in middle-aged individuals. Of those variables, smoking and PWV were the most important.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2022-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cpf.12800","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9324958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of the mechanosensitive piezo1 channel in intervertebral disc degeneration 力学敏感性piezo1通道在椎间盘退变中的作用

IF 1.8 4区医学 Q3 Medicine

Clinical Physiology and Functional Imaging

Pub Date : 2022-11-18 DOI: 10.1111/cpf.12798

Sheng Guo, Chenglong Wang, Changming Xiao, Qinwen Gu, Longhai Long, Xiaoqiang Wang, Houping Xu, Sen Li

Intervertebral disc degeneration (IDD) is a multifactorial skeletal disease involving mechanical, genetic, systemic, and biological factors, and it is characterized by apoptosis of the nucleus pulposus cells and breakdown of the extracellular matrix (ECM), which will impair the structure and function of the intervertebral disc (IVD), and cause low back pain. Recently, the piezo1 is recognized as a critical mechanically activated ion channel of IDD. Numerous studies have reported that the piezo1 ion channel was aberrantly activated in the degenerated disc tissues and deeply participated in the pathogenesis of IDD. Inactivating or interfering with the piezo1 channel could effectively prevent the progression of IDD under the experimental conditions. It may be a promising target for the prevention and treatment of the disabling disease. Therefore, we have to make a comprehensive investigation and understanding of the mechanisms and functions of the piezo1 in the biomechanics of the spine. This study mainly elucidates the role of the piezo1 channel in IDD, which may facilitate the development of therapeutic targets for this disease.

椎间盘退变（IDD）是一种涉及机械、遗传、系统和生物因素的多因素骨骼疾病，其特征是髓核细胞凋亡和细胞外基质（ECM）破坏，从而损害椎间盘（IVD）的结构和功能，并引起腰痛。最近，压电1被认为是IDD的关键机械激活离子通道。许多研究报道，在退行性椎间盘组织中，压电1离子通道被异常激活，并深入参与了IDD的发病机制。在实验条件下，停用或干扰压电1通道可以有效地阻止IDD的发展。它可能是预防和治疗致残性疾病的一个很有前途的靶点。因此，我们必须全面研究和理解压电1在脊柱生物力学中的作用机制。本研究主要阐明压电1通道在IDD中的作用，这可能有助于开发该疾病的治疗靶点。

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引用次数: 2