Elena Saracco, Nicolò Rashidy, Richard Borrelli, Federico Meli, Salvatore Schinocca, Luca Lo Sardo, Iuliana Badiu, Federica Corradi, Stefania Nicola, Luisa Brussino
{"title":"Allergic cheilitis due to stannous fluoride-containing toothpaste: First case from Italy and mini-review of previously published cases","authors":"Elena Saracco, Nicolò Rashidy, Richard Borrelli, Federico Meli, Salvatore Schinocca, Luca Lo Sardo, Iuliana Badiu, Federica Corradi, Stefania Nicola, Luisa Brussino","doi":"10.1111/cod.14625","DOIUrl":"10.1111/cod.14625","url":null,"abstract":"","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141466687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A case report of allergic contact dermatitis to benzisothiazolinone in a laundry detergent","authors":"Mun Wai Lam, Tang Ngee Shim","doi":"10.1111/cod.14626","DOIUrl":"10.1111/cod.14626","url":null,"abstract":"","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141455773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Christoffer Kursawe Larsen, Mikkel Bak Jensen, Jakob F. B. Schwensen
<p><i>N</i>-isopropyl-<i>N</i>′-phenyl-paraphenylenediamine (IPPD) is used as antioxidant in industrial black rubber items such as tyres and domestic rubber products such as sport watches<span><sup>1, 2</sup></span> IPPD may cause allergic contact dermatitis known as “Volkswagen dermatitis.”<span><sup>3</sup></span> The European baseline series (EBS) contains IPPD (0.1% in pet.).<span><sup>4</sup></span> The prevalence of contact allergy (CA) to IPPD is low in many studies (<1%).<span><sup>5</sup></span> IPPD is considered a screening allergen in favour of black rubber mix (IPPD), <i>N</i>-cyclohexyl-<i>N</i>-phenyl-4-phenylenediamine (CPPD) and <i>N</i>,<i>N</i>′-diphenyl-p-phenylenediamine (DPPD) that was removed from the EBS in 1992 as CPPD and DPPD were in short supply.<span><sup>6</sup></span> Though, testing with IPPD alone may result in underdiagnosing.<span><sup>7</sup></span> New surveillance data on IPPD are needed. [Correction added on 4 September 2024, after first online publication: The heading ‘BACKGROUND’ has been removed in this version.]</p><p>The objective of this study is to investigate the epidemiology of CA to IPPD from 2013 to 2023.</p><p>An observational study using historical data from the Allergen Database at Gentofte Hospital, Denmark, was conducted. We included patients ≥18 years old being consecutively patch tested with IPPD (0.1% in pet.). at Gentofte Hospital from 2013 to 2023. Patch testing was performed and interpreted as previously.<span><sup>8</sup></span> Patients patch tested several times during our study period were likewise handled as previously.<span><sup>8</sup></span> Information on patch test results, current clinical relevance,<span><sup>8</sup></span> the MOAHLFA-index (Male/Occupational dermatitis/Atopic dermatitis/Hand dermatitis/Leg dermatitis/Facial dermatitis/Age >40), and occupation was extracted.<span><sup>8</sup></span> Time trends were assessed using the Cochrane-Armitage test for trend. Associations between IPPD CA and the MOAHLFA-index were assessed by binary logistic regressions adjusting for sex, age >40/≤40, and atopic dermatitis. Further, crude odds ratios were calculated.</p><p>As sub-analysis, patch test results on patients tested with CPPD, DPPD or <i>N</i>,<i>N</i>-di-2-naphthyl-4-phenylenediamine (all 1% in pet.) as part of the specialised rubber series from 2013 to 2023 were extracted.</p><p>A <i>p</i>-value <0.05 was considered significant. SPSS Statistics-25 and R-version-2023.12.0 were used for statistical analysis. The study is approved under the umbrella project (p-2023-14 475), <i>Region Hovedstaden - Forskningsjuras</i> internal directory of active research projects.</p><p>A total of 7575 unique patients were consecutively patch tested with IPPD from 2013 to 2023. The overall prevalence of CA to IPPD was 0.41% (31/7575) and a significantly decreasing trend was identified from 2013 to 2023 (Cochrane-Armitage <i>p</i> < 0.05) (Figure 1). The current clinical rel
{"title":"Contact allergy to N-isopropyl-N′-phenyl paraphenylenediamine in consecutively patch tested Danish eczema patients: An observational study with historical data from 2013 to 2023","authors":"Christoffer Kursawe Larsen, Mikkel Bak Jensen, Jakob F. B. Schwensen","doi":"10.1111/cod.14629","DOIUrl":"10.1111/cod.14629","url":null,"abstract":"<p><i>N</i>-isopropyl-<i>N</i>′-phenyl-paraphenylenediamine (IPPD) is used as antioxidant in industrial black rubber items such as tyres and domestic rubber products such as sport watches<span><sup>1, 2</sup></span> IPPD may cause allergic contact dermatitis known as “Volkswagen dermatitis.”<span><sup>3</sup></span> The European baseline series (EBS) contains IPPD (0.1% in pet.).<span><sup>4</sup></span> The prevalence of contact allergy (CA) to IPPD is low in many studies (<1%).<span><sup>5</sup></span> IPPD is considered a screening allergen in favour of black rubber mix (IPPD), <i>N</i>-cyclohexyl-<i>N</i>-phenyl-4-phenylenediamine (CPPD) and <i>N</i>,<i>N</i>′-diphenyl-p-phenylenediamine (DPPD) that was removed from the EBS in 1992 as CPPD and DPPD were in short supply.<span><sup>6</sup></span> Though, testing with IPPD alone may result in underdiagnosing.<span><sup>7</sup></span> New surveillance data on IPPD are needed. [Correction added on 4 September 2024, after first online publication: The heading ‘BACKGROUND’ has been removed in this version.]</p><p>The objective of this study is to investigate the epidemiology of CA to IPPD from 2013 to 2023.</p><p>An observational study using historical data from the Allergen Database at Gentofte Hospital, Denmark, was conducted. We included patients ≥18 years old being consecutively patch tested with IPPD (0.1% in pet.). at Gentofte Hospital from 2013 to 2023. Patch testing was performed and interpreted as previously.<span><sup>8</sup></span> Patients patch tested several times during our study period were likewise handled as previously.<span><sup>8</sup></span> Information on patch test results, current clinical relevance,<span><sup>8</sup></span> the MOAHLFA-index (Male/Occupational dermatitis/Atopic dermatitis/Hand dermatitis/Leg dermatitis/Facial dermatitis/Age >40), and occupation was extracted.<span><sup>8</sup></span> Time trends were assessed using the Cochrane-Armitage test for trend. Associations between IPPD CA and the MOAHLFA-index were assessed by binary logistic regressions adjusting for sex, age >40/≤40, and atopic dermatitis. Further, crude odds ratios were calculated.</p><p>As sub-analysis, patch test results on patients tested with CPPD, DPPD or <i>N</i>,<i>N</i>-di-2-naphthyl-4-phenylenediamine (all 1% in pet.) as part of the specialised rubber series from 2013 to 2023 were extracted.</p><p>A <i>p</i>-value <0.05 was considered significant. SPSS Statistics-25 and R-version-2023.12.0 were used for statistical analysis. The study is approved under the umbrella project (p-2023-14 475), <i>Region Hovedstaden - Forskningsjuras</i> internal directory of active research projects.</p><p>A total of 7575 unique patients were consecutively patch tested with IPPD from 2013 to 2023. The overall prevalence of CA to IPPD was 0.41% (31/7575) and a significantly decreasing trend was identified from 2013 to 2023 (Cochrane-Armitage <i>p</i> < 0.05) (Figure 1). The current clinical rel","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cod.14629","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141455775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}