Pub Date : 2025-09-16DOI: 10.1016/j.ctim.2025.103244
Heon Heo , DooChul Shin
Background
Upper chest breathing patterns can increase accessory muscle activation and reduce cervical stability, contributing to neck pain
Objective
To examine the effects of a respiratory exercise program on pain, cervical range of motion, disability, breathing patterns, and muscular endurance in patients with non-specific neck pain.
Design
randomized controlled trial
Methods
Thirty-two patients with non-specific neck pain and upper chest breathing patterns were included. The study was conducted from July 19, 2021, to September 3, at a physical therapy center. Participants were randomly assigned to a breathing exercise (BE) or neck exercise (NE) group. Thermoelectric therapy, soft tissue relaxation, and thoracic spine mobilization were performed in both groups. The BE group performed breathing exercises, whereas the NE group performed general neck exercises. Pain intensity, neck disability index, cervical range of motion, breathing pattern, and deep cervical flexor endurance were measured before and after the intervention. Paired t-test and independent t-test compared pre- and post-test differences within and between groups.
Results
Both groups showed significant improvements in pain intensity and NDI (pain: BE vs NE mean difference 0.34, 95 % CI –0.25–0.93, p = .239; NDI: 0.86, 95 % CI –0.62–2.34, p = .249). Breathing pattern improved only in the BE group (mean difference 2.73, 95 % CI 1.78–3.68, p < .001). Endurance of deep cervical flexors increased in both groups, greater in NE (mean difference –15.98, 95 % CI –25.26 to –6.70, p = .010).
Conclusion
Breathing exercises improved breathing patterns in patients with non-specific neck pain, but effects on pain and disability were inconclusive.
背景：上胸部呼吸模式可增加副肌激活，降低颈椎稳定性，导致颈部疼痛。目的：研究呼吸锻炼方案对非特异性颈部疼痛患者疼痛、颈椎活动度、残疾、呼吸模式和肌肉耐力的影响。设计：随机对照试验方法：纳入32例非特异性颈部疼痛和上胸呼吸方式的患者。该研究于2021年7月19日至9月3日在物理治疗中心进行。参与者被随机分配到呼吸运动（BE）组或颈部运动（NE）组。两组均行热电治疗、软组织松弛、胸椎活动。BE组进行呼吸练习，而NE组进行一般的颈部练习。测量干预前后疼痛强度、颈部残疾指数、颈椎活动度、呼吸方式、颈深屈肌耐力。配对t检验和独立t检验比较组内和组间检验前后的差异。结果：两组疼痛强度和NDI均有显著改善（疼痛：BE vs NE平均差异0.34,95% CI -0.25 ~ 0.93, p= 0.239; NDI: 0.86, 95% CI -0.62 ~ 2.34, p= 0.249）。呼吸模式仅在BE组得到改善（平均差异2.73,95% CI 1.78至3.68）。结论：呼吸练习改善了非特异性颈部疼痛患者的呼吸模式，但对疼痛和残疾的影响尚无定论。
{"title":"The impact of a breathing exercise program on pain, disability, and breathing patterns in patients with non-specific neck pain: A randomized controlled trial","authors":"Heon Heo , DooChul Shin","doi":"10.1016/j.ctim.2025.103244","DOIUrl":"10.1016/j.ctim.2025.103244","url":null,"abstract":"<div><h3>Background</h3><div>Upper chest breathing patterns can increase accessory muscle activation and reduce cervical stability, contributing to neck pain</div></div><div><h3>Objective</h3><div>To examine the effects of a respiratory exercise program on pain, cervical range of motion, disability, breathing patterns, and muscular endurance in patients with non-specific neck pain.</div></div><div><h3>Design</h3><div>randomized controlled trial</div></div><div><h3>Methods</h3><div>Thirty-two patients with non-specific neck pain and upper chest breathing patterns were included. The study was conducted from July 19, 2021, to September 3, at a physical therapy center. Participants were randomly assigned to a breathing exercise (BE) or neck exercise (NE) group. Thermoelectric therapy, soft tissue relaxation, and thoracic spine mobilization were performed in both groups. The BE group performed breathing exercises, whereas the NE group performed general neck exercises. Pain intensity, neck disability index, cervical range of motion, breathing pattern, and deep cervical flexor endurance were measured before and after the intervention. Paired t-test and independent t-test compared pre- and post-test differences within and between groups.</div></div><div><h3>Results</h3><div>Both groups showed significant improvements in pain intensity and NDI (pain: BE vs NE mean difference 0.34, 95 % CI –0.25–0.93, p = .239; NDI: 0.86, 95 % CI –0.62–2.34, p = .249). Breathing pattern improved only in the BE group (mean difference 2.73, 95 % CI 1.78–3.68, p < .001). Endurance of deep cervical flexors increased in both groups, greater in NE (mean difference –15.98, 95 % CI –25.26 to –6.70, p = .010).</div></div><div><h3>Conclusion</h3><div>Breathing exercises improved breathing patterns in patients with non-specific neck pain, but effects on pain and disability were inconclusive.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"94 ","pages":"Article 103244"},"PeriodicalIF":3.5,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145085225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-13DOI: 10.1016/j.ctim.2025.103242
Hamidreza Shiri , Ali Akbar Soleimani , Behnam Omidi Sarajar , Abdolkarim Talebi Taheri , Fataneh Esmaeili , Mohammad Hadi Nematollahi , Mahmood Alizadeh Sani
Introduction
CVDs are considered the major public health concern and mortality in the world. Common treatments have some side effects and require low-risk treatments, such as herbal medicine. Spirulina is a filamentous microalga that has improved cardiometabolic parameters.
Methods
Systematic searches were conducted in Scopus, ISI Web of Science, and PubMed/Medline databases up to 20 January 2025 to identify RCTs based on the PRISMA checklist and PICOS criteria (People > 18 years, Intervention: spirulina, Comparison: placebo /control, Outcomes: TG, TC, LDL-C, HDL-C, FBG, HbA1c, insulin, HOMA-IR, SBP, DBP, BMI, weight, hs-CRP, IL-6, TNF-α, and Study: RCTs). Meta- analysis was utilized by random-effects models, and the GRADE criteria ensured the certainty of results.
Result
The results of 35 trials (45 effect sizes) show that spirulina intake improved glucose homeostasis (FBG; WMD: −5.51 (mg/dl); P = 0.001, HOMA-IR; WMD: −0.68; P < 0.001, and insulin; WMD: −0.86 (ng/ml); P = 0.002), decreased dyslipidemia (TG; WMD: −14.75 (mg/dl); P < 0.001, TC: WMD: −11.5 (mg/dl); P < 0.001, LDL-C; WMD: −7.69 (mg/dl); P < 0.001, and HDL-C; WMD: 1.9 (mg/dl); P < 0.001), decreased blood pressure (SBP; WMD: −3.85 mmHg, P = 0.002, and DBP; WMD: −3.09 mmHg, P < 0.001), reduced anthropometric indexes (weight; WMD: −1.78 kg; P = 0.003, and BMI; WMD: −0.58 kg/m²; P = 0.001), and decreased inflammation (TNF-α; WMD: −0.46 pg/ml; P = 0.01, IL-6; WMD: −0.58 pg/ml; P < 0.001, and hs-CRP; WMD: −0.86 mg/L; P = 0.002). Based on GRADE analysis, LDL-C, FBG, and HbA1c had of low quality, while the outcome for weight was of high quality. Furthermore, other parameters had moderate-quality outcomes.
Conclusion
This study demonstrates that spirulina supplementation effectively reduces the risk of CVD in adults by improving glucose homeostasis, dyslipidemia, blood pressure, anthropometric indexes, and inflammation. So, intake of spirulina is an adjunct or complementary to improve cardiometabolic profiles.
Trial registration
PROSPERO registration cod: (CRD42024626090)
心血管疾病被认为是世界上主要的公共卫生问题和死亡率。普通的治疗方法有一些副作用，需要低风险的治疗，比如草药。螺旋藻是一种丝状微藻，具有改善心脏代谢参数的作用。方法系统检索Scopus、ISI Web of Science和PubMed/Medline数据库，截至2025年1月20日，根据PRISMA检查表和PICOS标准（患者18岁，干预：螺旋藻，比较：安慰剂/对照，结局：TG、TC、LDL-C、HDL-C、FBG、HbA1c、胰岛素、HOMA-IR、收缩压、舒压、BMI、体重、hs-CRP、IL-6、TNF-α和研究：rct）确定rct。随机效应模型采用Meta分析，GRADE标准保证了结果的确定性。结果35项试验（45个效应量）的结果表明，螺旋藻摄入改善了葡萄糖稳态(FBG; WMD: - 5.51 (mg/dl)；0.001 P = HOMA-IR;大规模杀伤性武器:−0.68;P <； 0.001，胰岛素；WMD:−0.86 (ng/ml)；P = 0.002)，降低血脂异常(TG; WMD:−14.75 (mg/dl)；P <； 0.001,TC: WMD: - 11.5 (mg/dl)；P & lt; 0.001,低密度;WMD:−7.69 (mg/dl)；P <； 0.001,HDL-C；WMD: 1.9 (mg/dl)；P & lt; 0.001),降低血压(SBP;大规模杀伤性武器:−3.85 mmHg, P = 0.002,和菲律宾;大规模杀伤性武器:−3.09 mmHg, P & lt; 0.001),降低人体测量指标(体重;大规模杀伤性武器:− 公斤1.78;P = 0.003,体重指数;大规模杀伤性武器:−0.58 公斤/ m²;P = 0.001),并降低炎症(TNF -α;大规模杀伤性武器:−0.46 pg / ml; P = 0.01,il - 6,大规模杀伤性武器:−0.58 pg / ml; P & lt; 0.001,和hs-CRP;大规模杀伤性武器:−0.86 mg / L; P = 0.002)。根据GRADE分析，LDL-C、FBG和HbA1c的结果质量较低，而体重的结果质量较高。此外，其他参数具有中等质量的结果。结论本研究表明，螺旋藻补充可通过改善葡萄糖稳态、血脂异常、血压、人体测量指标和炎症，有效降低成人心血管疾病的风险。因此，螺旋藻的摄入是一种辅助或补充，以改善心脏代谢谱。试用注册普洛斯佩罗注册编号：（CRD42024626090）
{"title":"Spirulina’s impacts on cardiovascular health: Insights from a systematic meta-analysis of RCT","authors":"Hamidreza Shiri , Ali Akbar Soleimani , Behnam Omidi Sarajar , Abdolkarim Talebi Taheri , Fataneh Esmaeili , Mohammad Hadi Nematollahi , Mahmood Alizadeh Sani","doi":"10.1016/j.ctim.2025.103242","DOIUrl":"10.1016/j.ctim.2025.103242","url":null,"abstract":"<div><h3>Introduction</h3><div>CVDs are considered the major public health concern and mortality in the world. Common treatments have some side effects and require low-risk treatments, such as herbal medicine. Spirulina is a filamentous microalga that has improved cardiometabolic parameters.</div></div><div><h3>Methods</h3><div>Systematic searches were conducted in Scopus, ISI Web of Science, and PubMed/Medline databases up to 20 January 2025 to identify RCTs based on the PRISMA checklist and PICOS criteria (People > 18 years, Intervention: spirulina, Comparison: placebo /control, Outcomes: TG, TC, LDL-C, HDL-C, FBG, HbA1c, insulin, HOMA-IR, SBP, DBP, BMI, weight, hs-CRP, IL-6, TNF-α, and Study: RCTs). Meta- analysis was utilized by random-effects models, and the GRADE criteria ensured the certainty of results.</div></div><div><h3>Result</h3><div>The results of 35 trials (45 effect sizes) show that spirulina intake improved glucose homeostasis (FBG; WMD: −5.51 (mg/dl); <em>P</em> = 0.001, HOMA-IR; WMD: −0.68; <em>P</em> < 0.001, and insulin; WMD: −0.86 (ng/ml); <em>P</em> = 0.002), decreased dyslipidemia (TG; WMD: −14.75 (mg/dl); <em>P</em> < 0.001, TC: WMD: −11.5 (mg/dl); <em>P</em> < 0.001, LDL-C; WMD: −7.69 (mg/dl); <em>P</em> < 0.001, and HDL-C; WMD: 1.9 (mg/dl); <em>P</em> < 0.001), decreased blood pressure (SBP; WMD: −3.85 mmHg, <em>P</em> = 0.002, and DBP; WMD: −3.09 mmHg, <em>P</em> < 0.001), reduced anthropometric indexes (weight; WMD: −1.78 kg; <em>P</em> = 0.003, and BMI; WMD: −0.58 kg/m²; <em>P</em> = 0.001), and decreased inflammation (TNF-α; WMD: −0.46 pg/ml; <em>P</em> = 0.01, IL-6; WMD: −0.58 pg/ml; <em>P</em> < 0.001, and hs-CRP; WMD: −0.86 mg/L; <em>P</em> = 0.002). Based on GRADE analysis, LDL-C, FBG, and HbA1c had of low quality, while the outcome for weight was of high quality. Furthermore, other parameters had moderate-quality outcomes.</div></div><div><h3>Conclusion</h3><div>This study demonstrates that spirulina supplementation effectively reduces the risk of CVD in adults by improving glucose homeostasis, dyslipidemia, blood pressure, anthropometric indexes, and inflammation. So, intake of spirulina is an adjunct or complementary to improve cardiometabolic profiles.</div></div><div><h3>Trial registration</h3><div>PROSPERO registration cod: (CRD42024626090)</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"94 ","pages":"Article 103242"},"PeriodicalIF":3.5,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145059937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-10DOI: 10.1016/j.ctim.2025.103205
Maureen Bilinga Tendwa , Tejaswini Appidi , Brylyne Chitsunge , Michele Moreau , Blessed Okole , Lonji Kalombo , Abba Mallum , Twalib Ngoma , Daniel P. Weadock , Eric Tanifum , Simon Erridge , Mikael Sodergren , Rob Sims , Calvin Johnson , Ngeh Toyang , Henry Lowe , Bashkim Ziberi , Luc Richner , Sandra Carrillo , Stephen Avery , Wilfred Ngwa
Introduction
The growing opioid crisis and persistent global health disparities underscore the urgent need for alternative therapeutic strategies. Cannabis, with its long-standing historical use and recent legislative developments, presents a potentially significant avenue for addressing these challenges. This review examines the evolving landscape of medicinal cannabis, drawing from historical ethnopharmacological data and contemporary scientific discussions.
Methods
This review synthesized evidence from historical ethnobotanical records, peer-reviewed studies, and outcomes derived from recent Global Health events. These events facilitated discussions among diverse stakeholders, including healthcare professionals, policymakers, researchers, industry representatives, farmers, and patient advocates. Case studies and successful models from the USA and Africa, including the recent FDA approval for first-in-human clinical trials of a medicinal cannabis derivative for pancreatic cancer, were analysed.
Results
Successful models include collaborative platforms fostering stakeholder engagement, such as partnerships between African farmers and biotech firms to standardize cultivation. Successful models demonstrate the potential for adaptation and scaling in diverse healthcare settings. The FDA trial approval exemplifies progress in clinical translation. However, disparities persist, with patients within Africa facing systemic barriers to medical Cannabis certification and higher rates of punitive opioid discontinuation.
Conclusion
Medicinal Cannabis presents a complex yet promising solution for reducing opioid-related mortality and addressing healthcare inequities. Implementing strategic frameworks like CORE (Care, Outreach, Research, Education) is essential for developing safe, high-quality, evidence-based cannabis products. Through fostering collaboration and addressing existing obstacles, the therapeutic potential of medicinal Cannabis can be harnessed to mitigate the opioid crisis and reduce global health disparities, effectively translating research from farm to bedside.
{"title":"From farm to bedside: Potential of medical cannabis in global health","authors":"Maureen Bilinga Tendwa , Tejaswini Appidi , Brylyne Chitsunge , Michele Moreau , Blessed Okole , Lonji Kalombo , Abba Mallum , Twalib Ngoma , Daniel P. Weadock , Eric Tanifum , Simon Erridge , Mikael Sodergren , Rob Sims , Calvin Johnson , Ngeh Toyang , Henry Lowe , Bashkim Ziberi , Luc Richner , Sandra Carrillo , Stephen Avery , Wilfred Ngwa","doi":"10.1016/j.ctim.2025.103205","DOIUrl":"10.1016/j.ctim.2025.103205","url":null,"abstract":"<div><h3>Introduction</h3><div>The growing opioid crisis and persistent global health disparities underscore the urgent need for alternative therapeutic strategies. <em>Cannabis</em>, with its long-standing historical use and recent legislative developments, presents a potentially significant avenue for addressing these challenges. This review examines the evolving landscape of medicinal cannabis, drawing from historical ethnopharmacological data and contemporary scientific discussions.</div></div><div><h3>Methods</h3><div>This review synthesized evidence from historical ethnobotanical records, peer-reviewed studies, and outcomes derived from recent Global Health events. These events facilitated discussions among diverse stakeholders, including healthcare professionals, policymakers, researchers, industry representatives, farmers, and patient advocates. Case studies and successful models from the USA and Africa, including the recent FDA approval for first-in-human clinical trials of a medicinal cannabis derivative for pancreatic cancer, were analysed.</div></div><div><h3>Results</h3><div>Successful models include collaborative platforms fostering stakeholder engagement, such as partnerships between African farmers and biotech firms to standardize cultivation. Successful models demonstrate the potential for adaptation and scaling in diverse healthcare settings. The FDA trial approval exemplifies progress in clinical translation. However, disparities persist, with patients within Africa facing systemic barriers to medical <em>Cannabis</em> certification and higher rates of punitive opioid discontinuation.</div></div><div><h3>Conclusion</h3><div>Medicinal <em>Cannabis</em> presents a complex yet promising solution for reducing opioid-related mortality and addressing healthcare inequities. Implementing strategic frameworks like CORE (Care, Outreach, Research, Education) is essential for developing safe, high-quality, evidence-based cannabis products. Through fostering collaboration and addressing existing obstacles, the therapeutic potential of medicinal <em>Cannabis</em> can be harnessed to mitigate the opioid crisis and reduce global health disparities, effectively translating research from farm to bedside.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"93 ","pages":"Article 103205"},"PeriodicalIF":3.5,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145026431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dyslipidemia is a significant risk factor for cardiovascular disease. Traditional treatments often focus on pharmacological interventions; however, alternative therapies, such as hot spring and sauna use, have recently gained attention because of their potentially beneficial effects on lipid profiles and cardiovascular health.
Design and setting
This systematic review aimed to synthesize current evidence on the efficacy of hot spring and sauna use, alone or combined with exercise therapy, in improving blood lipid profiles, with a focus on mechanisms, benefits, and limitations.
Methods
The review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A search of 330 records across major databases identified 127 studies for blinded screening using Rayyan (a web-based application for conducting systematic reviews). Seven randomized controlled trials (RCTs) investigating the effects of hot spring and sauna use on lipid profiles in adults were included.
Results
Four RCTs in younger adults (mean age < 60 years) demonstrated that hot spring and sauna use resulted in reductions in serum total cholesterol and low-density lipoprotein cholesterol; these therapies were given a weak expert recommendation. Three RCTs in older adults (mean age ≥ 60 years) showed no significant blood lipid changes.
Conclusions
In younger adults, hot spring and sauna use, particularly when combined with exercise therapy, may contribute to improved lipid profiles. Emerging evidence from intervention studies could inform future guidelines for integrating these therapies into dyslipidemia management strategies.
{"title":"Hot spring and sauna use for improving blood lipid profiles: A systematic review and expert consensus on efficacy and recommendations","authors":"Satoshi Yamasaki , Tomotake Tokunou , Yusuke Kashiwado , Mari Makishi , Takahiko Horiuchi","doi":"10.1016/j.ctim.2025.103241","DOIUrl":"10.1016/j.ctim.2025.103241","url":null,"abstract":"<div><h3>Objectives</h3><div>Dyslipidemia is a significant risk factor for cardiovascular disease. Traditional treatments often focus on pharmacological interventions; however, alternative therapies, such as hot spring and sauna use, have recently gained attention because of their potentially beneficial effects on lipid profiles and cardiovascular health.</div></div><div><h3>Design and setting</h3><div>This systematic review aimed to synthesize current evidence on the efficacy of hot spring and sauna use, alone or combined with exercise therapy, in improving blood lipid profiles, with a focus on mechanisms, benefits, and limitations.</div></div><div><h3>Methods</h3><div>The review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A search of 330 records across major databases identified 127 studies for blinded screening using Rayyan (a web-based application for conducting systematic reviews). Seven randomized controlled trials (RCTs) investigating the effects of hot spring and sauna use on lipid profiles in adults were included.</div></div><div><h3>Results</h3><div>Four RCTs in younger adults (mean age < 60 years) demonstrated that hot spring and sauna use resulted in reductions in serum total cholesterol and low-density lipoprotein cholesterol; these therapies were given a weak expert recommendation. Three RCTs in older adults (mean age ≥ 60 years) showed no significant blood lipid changes.</div></div><div><h3>Conclusions</h3><div>In younger adults, hot spring and sauna use, particularly when combined with exercise therapy, may contribute to improved lipid profiles. Emerging evidence from intervention studies could inform future guidelines for integrating these therapies into dyslipidemia management strategies.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"94 ","pages":"Article 103241"},"PeriodicalIF":3.5,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145005376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-01DOI: 10.1016/j.ctim.2025.103240
Majed M. Alhumaid , Faris Yahya I. Asiri , Mohamed A. Said , Justin A. Haegele
{"title":"Corrigendum to “The efficacy of physical activity or exercise among individuals with cerebral palsy: An umbrella review of systematic reviews” [Complement Ther Med 93 (2025) 103228]","authors":"Majed M. Alhumaid , Faris Yahya I. Asiri , Mohamed A. Said , Justin A. Haegele","doi":"10.1016/j.ctim.2025.103240","DOIUrl":"10.1016/j.ctim.2025.103240","url":null,"abstract":"","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"93 ","pages":"Article 103240"},"PeriodicalIF":3.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144945713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-08-26DOI: 10.1016/j.ctim.2025.103239
Safa Saadani , Robert Jarai , Attila Szabo , Szilvia Boros
Background
Few studies have addressed mental health in finswimmers.
Objective
This study examines the effect of NLP used as mental training on the finswimmers’ anxiety, self-confidence, self-esteem, and swimming records.
Methods
The NLP intervention lasted two months. The study involved thirty young finswimmers (mean age M = 15.53, SD = 1.024), divided equally into two groups: the experimental and the control group. We carried out a pre- and post-test research design and conducted a follow-up test. We used two questionnaires, the French version of the CSAI-2R and the French version of the PSPP, along with semi-structured interviews for all three tests.
Results
In the post-intervention test, the experimental group significantly decreased their cognitive anxiety (β = −3.47, p < .001) and somatic anxiety (β = −2.20, p = .001). Significantly increased their self-confidence (β = 2.07, p < .001), their global self-esteem (β = 1.93, p = .002), and their physical self-worth (β = 2.13, p = .004). The same parameters, except for the global self-esteem, also recorded significant change in the follow-up test, p < .005. Time effect did not show significance in the body attractiveness, physical strength, physical conditioning, and sport competence. Furthermore, outcomes showed notable between-subject variability in the mental skills, suggesting substantial variability in baseline parameter levels between individuals. Consequently, the finswimmers enhanced their swimming records.
Conclusions
NLP showed a powerful impact in optimizing finswimmers’ mental health and, accordingly, their athletic performance. Besides, the technique showed relatively durable effectiveness. Coaches can reinforce the effect through ongoing NLP training.
很少有研究涉及游泳者的心理健康。目的探讨NLP作为心理训练对游泳运动员焦虑、自信、自尊和游泳成绩的影响。方法NLP干预持续2个月。研究对象为30名年轻的游泳运动员（平均年龄M = 15.53, SD = 1.024），平均分为实验组和对照组。我们进行了测试前和测试后的研究设计，并进行了跟踪测试。我们使用了两份问卷，法语版的CSAI-2R和法语版的PSPP，以及所有三个测试的半结构化访谈。结果干预后测试中，实验组认知焦虑显著降低（β = - 3.47, p <； ）。001)和躯体焦虑（β =−2.20,p = .001）。显著提高自信心（β = 2.07, p <； ）。001)，他们的整体自尊（β = 1.93, p = ）。002)，身体自我价值感（β = 2.13, p = .004）。相同的参数，除了整体自尊，在后续测试中也记录了显著的变化，p <； .005。时间效应在身体吸引力、体力、体能和运动能力上均不显著。此外，结果显示受试者之间的心理技能存在显著差异，表明个体之间的基线参数水平存在显著差异。因此，游泳运动员提高了他们的游泳记录。结论单核苷酸多态性对改善游泳运动员的心理健康和运动成绩有显著影响。此外，该技术显示出相对持久的有效性。教练可以通过持续的NLP训练来强化这种效果。
{"title":"The impact of neurolinguistic programming on anxiety, self-confidence, self-esteem, and performance in non-elite finswimmers","authors":"Safa Saadani , Robert Jarai , Attila Szabo , Szilvia Boros","doi":"10.1016/j.ctim.2025.103239","DOIUrl":"10.1016/j.ctim.2025.103239","url":null,"abstract":"<div><h3>Background</h3><div>Few studies have addressed mental health in finswimmers.</div></div><div><h3>Objective</h3><div>This study examines the effect of NLP used as mental training on the finswimmers’ anxiety, self-confidence, self-esteem, and swimming records.</div></div><div><h3>Methods</h3><div>The NLP intervention lasted two months. The study involved thirty young finswimmers (mean age M = 15.53, SD = 1.024), divided equally into two groups: the experimental and the control group. We carried out a pre- and post-test research design and conducted a follow-up test. We used two questionnaires, the French version of the CSAI-2R and the French version of the PSPP, along with semi-structured interviews for all three tests.</div></div><div><h3>Results</h3><div>In the post-intervention test, the experimental group significantly decreased their cognitive anxiety (β = −3.47, p < .001) and somatic anxiety (β = −2.20, p = .001). Significantly increased their self-confidence (β = 2.07, p < .001), their global self-esteem (β = 1.93, p = .002), and their physical self-worth (β = 2.13, p = .004). The same parameters, except for the global self-esteem, also recorded significant change in the follow-up test, p < .005. Time effect did not show significance in the body attractiveness, physical strength, physical conditioning, and sport competence. Furthermore, outcomes showed notable between-subject variability in the mental skills, suggesting substantial variability in baseline parameter levels between individuals. Consequently, the finswimmers enhanced their swimming records.</div></div><div><h3>Conclusions</h3><div>NLP showed a powerful impact in optimizing finswimmers’ mental health and, accordingly, their athletic performance. Besides, the technique showed relatively durable effectiveness. Coaches can reinforce the effect through ongoing NLP training.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"93 ","pages":"Article 103239"},"PeriodicalIF":3.5,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144922180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
There is growing interest in the therapeutic application of ozone (OZ) and hyaluronic acid (HA) for individuals suffering from osteoarthritis. This randomized trial aimed to assess the effectiveness of HA versus a mixture of OZ and HA in alleviating pain for patients diagnosed with OA.
Methods
In a double-blind clinical trial, 60 patients diagnosed with OA were randomly divided into two groups: One group was administered four intra-articular (IA) injections of hyaluronic acid (HA) every week (HA group), while the second group received the same frequency of injections but with ozone combined with HA (OZ+HA group). Patients underwent evaluations for pain levels utilizing the Visual Analogue Scale (VAS), assessed their quality of life with support from Health-Related Quality of Life (HRQL) metrics, and analyzed sleep quality using the Pittsburgh Sleep Quality Index (PSQI) at initial assessment and again at 2 weeks, 2 months, and 6 months following the intervention.
Results
Results indicated a significant decrease in the VAS-score value for both groups after six months of intervention, with the OZ + HA group experiencing a greater reduction (P < 0.001 for both). The HRQL value changes were significantly more pronounced in the OZ+HA group than in the HA group by the end of the study (P < 0.001). The decrease in the PSQI score in the OZ + HA group following six months of intervention was substantially less compared to the HA group (P < 0.001).
Conclusion
The combination of ozone and HA appears to have an enhancing effect on analgesic outcomes, sleep, and quality of life, indicating a need for further research.
{"title":"Comparing the efficacy of combining ozone therapy with hyaluronic acid versus using hyaluronic acid alone for pain relief in patients with knee osteoarthritis: A randomized clinical trial","authors":"Ghodrat Akhavanakbari , Maryam Asayeshi , Reza Noktehsanj , Mohammad Reza Aslani","doi":"10.1016/j.ctim.2025.103238","DOIUrl":"10.1016/j.ctim.2025.103238","url":null,"abstract":"<div><h3>Background</h3><div>There is growing interest in the therapeutic application of ozone (OZ) and hyaluronic acid (HA) for individuals suffering from osteoarthritis. This randomized trial aimed to assess the effectiveness of HA versus a mixture of OZ and HA in alleviating pain for patients diagnosed with OA.</div></div><div><h3>Methods</h3><div>In a double-blind clinical trial, 60 patients diagnosed with OA were randomly divided into two groups: One group was administered four intra-articular (IA) injections of hyaluronic acid (HA) every week (HA group), while the second group received the same frequency of injections but with ozone combined with HA (OZ+HA group). Patients underwent evaluations for pain levels utilizing the Visual Analogue Scale (VAS), assessed their quality of life with support from Health-Related Quality of Life (HRQL) metrics, and analyzed sleep quality using the Pittsburgh Sleep Quality Index (PSQI) at initial assessment and again at 2 weeks, 2 months, and 6 months following the intervention.</div></div><div><h3>Results</h3><div>Results indicated a significant decrease in the VAS-score value for both groups after six months of intervention, with the OZ + HA group experiencing a greater reduction (P < 0.001 for both). The HRQL value changes were significantly more pronounced in the OZ+HA group than in the HA group by the end of the study (P < 0.001). The decrease in the PSQI score in the OZ + HA group following six months of intervention was substantially less compared to the HA group (P < 0.001).</div></div><div><h3>Conclusion</h3><div>The combination of ozone and HA appears to have an enhancing effect on analgesic outcomes, sleep, and quality of life, indicating a need for further research.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"93 ","pages":"Article 103238"},"PeriodicalIF":3.5,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144925694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abnormal patellar alignment is closely linked to patellofemoral osteoarthritis (PFOA), with laterally tilted patellae often worsening pain. This study investigates the relationship between imaging parameter changes and pain levels by analyzing the effects of Tui Na (TN) and intra-articular hyaluronic acid injections (IAHA) intervention.
Methods
This study included 126 PFOA patients from Wangjing Hospital of the China Academy of Traditional Chinese Medicine, between October 8, 2022, and December 31, 2024. Participants were randomly assigned to the TN or IAHA group. The IAHA group received one injection per week for five weeks, while the TN group underwent three Tui Na sessions per week for four weeks. The Visual Analogue Scale (VAS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and patellar imaging indices (Lateral Patellar Displacement (LPD), Congruence Angle (CA), Lateral Patellofemoral Angle (LPFA), Patellofemoral Index (PFI)) were assessed before and one week after treatment. To investigate the correlation between imaging parameters and VAS scores, Spearman rank correlation analysis was applied to non-normally distributed data, with scatter plots used to elucidate trends in the association between pain and imaging parameters. A multiple linear regression model was constructed to assess the independent effects of imaging parameters on changes in VAS scores.
Results
Both TN and IAHA treatments significantly reduced VAS and WOMAC scores (p < 0.05). No significant difference was observed in VAS score improvements between the two groups (p > 0.05). However, the TN group showed a significantly greater improvement in WOMAC scores (p < 0.05). The TN group also exhibited better improvements in LPD and CA compared to the IAHA group (p < 0.05). Spearman's correlation showed no significant link between imaging indices and VAS scores (p > 0.05). Multiple regression analysis revealed that reductions in VAS scores were associated with decreases in LPD (β = 0.274, p = 0.038) and CA (β = 0.309, p = 0.033).
Conclusion
Tui Na is as effective as IAHA in relieving pain in PFOA patients, potentially alleviating pain through reductions in LPD and CA.
Trial registration
Chinese Clinical Trial Registry(ChiCTR), ChiCTR2200059345, Registered on 28/04/2022, https://www.chictr.org.cn/showproj.html?proj=166395
{"title":"Tuina improves patellofemoral osteoarthritis by alleviating the degree of lateral patellar tilt: a correlation analysis based on a randomized controlled trial","authors":"Jinguang Gu , Yongli Dong , Guangcheng Wei , Zechuan Zhuo , Aolin Sun , Dongliang Wei , Yong Zhao , Weikai Qin","doi":"10.1016/j.ctim.2025.103234","DOIUrl":"10.1016/j.ctim.2025.103234","url":null,"abstract":"<div><h3>Purpose</h3><div>Abnormal patellar alignment is closely linked to patellofemoral osteoarthritis (PFOA), with laterally tilted patellae often worsening pain. This study investigates the relationship between imaging parameter changes and pain levels by analyzing the effects of Tui Na (TN) and intra-articular hyaluronic acid injections (IAHA) intervention.</div></div><div><h3>Methods</h3><div>This study included 126 PFOA patients from Wangjing Hospital of the China Academy of Traditional Chinese Medicine, between October 8, 2022, and December 31, 2024. Participants were randomly assigned to the TN or IAHA group. The IAHA group received one injection per week for five weeks, while the TN group underwent three Tui Na sessions per week for four weeks. The Visual Analogue Scale (VAS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and patellar imaging indices (Lateral Patellar Displacement (LPD), Congruence Angle (CA), Lateral Patellofemoral Angle (LPFA), Patellofemoral Index (PFI)) were assessed before and one week after treatment. To investigate the correlation between imaging parameters and VAS scores, Spearman rank correlation analysis was applied to non-normally distributed data, with scatter plots used to elucidate trends in the association between pain and imaging parameters. A multiple linear regression model was constructed to assess the independent effects of imaging parameters on changes in VAS scores.</div></div><div><h3>Results</h3><div>Both TN and IAHA treatments significantly reduced VAS and WOMAC scores (p < 0.05). No significant difference was observed in VAS score improvements between the two groups (p > 0.05). However, the TN group showed a significantly greater improvement in WOMAC scores (p < 0.05). The TN group also exhibited better improvements in LPD and CA compared to the IAHA group (p < 0.05). Spearman's correlation showed no significant link between imaging indices and VAS scores (p > 0.05). Multiple regression analysis revealed that reductions in VAS scores were associated with decreases in LPD (β = 0.274, p = 0.038) and CA (β = 0.309, p = 0.033).</div></div><div><h3>Conclusion</h3><div>Tui Na is as effective as IAHA in relieving pain in PFOA patients, potentially alleviating pain through reductions in LPD and CA.</div></div><div><h3>Trial registration</h3><div>Chinese Clinical Trial Registry(ChiCTR), ChiCTR2200059345, Registered on 28/04/2022, <span><span>https://www.chictr.org.cn/showproj.html?proj=166395</span><svg><path></path></svg></span></div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"93 ","pages":"Article 103234"},"PeriodicalIF":3.5,"publicationDate":"2025-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144917816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-08-23DOI: 10.1016/j.ctim.2025.103237
Zhaoying Yan , Tao Zhang , Zifan Ding , Baole Tao , Junwen Shu , Minlei Yu , Qingyu Liang , Jun Yan
Background
Elderly patients with Chronic Obstructive Pulmonary Disease (COPD) commonly suffer from anxiety, depression, and impaired health-related quality of life (HRQOL). This review evaluated the effects of mind-body exercises on these outcomes and exercise tolerance in COPD patients aged ≥ 60 years.
Methods
Following PRISMA guidelines, we systematically searched PubMed, Embase, PsycINFO, Cochrane Library, and Web of Science (inception-January 2025) for randomized controlled trials (RCTs) comparing mind-body exercise versus usual care. Outcomes were anxiety, depression, HRQOL (St. George's Respiratory Questionnaire or Chronic Respiratory Questionnaire), and exercise tolerance (6-minute walk test). Meta-analyses used random-effects models, reporting Standardized Mean Differences (SMDs) or Mean Differences (MDs) with 95 % confidence intervals (CIs). Evidence certainty was assessed (GRADE framework). Seventeen RCTs were included.
Results
Mind-body exercise reduced anxiety (SMD = −0.59, 95 % CI: −0.84 to −0.34; high certainty) and depression (SMD = −0.34, 95 % CI: −0.54 to −0.14; high certainty). HRQOL improved significantly (SMD = −0.79, 95 % CI: −1.14 to −0.44; low certainty), with exploratory findings showing greater improvement in Southeast Asian patients (SMD = −3.41). Exercise tolerance increased (MD = 44.23 m, 95 % CI: 26.12–62.34), exceeding minimal clinically important differences. Intervention duration for depression was a key moderator, with greater benefits in patients with interventions lasting ≥ 3080 min.
Conclusion
Mind-body exercise reduces anxiety and depression, improves health-related quality of life, and increases exercise tolerance in elderly patients with COPD. For anxiety and depression, benefits are significantly enhanced with intervention durations ≥ 3080 minutes. Incorporating mind-body exercise into comprehensive COPD management for older adults is recommended.
{"title":"Effects of a mind-body exercise intervention on anxiety, depression and quality of life in elderly patients with chronic obstructive pulmonary disease: A systematic evaluation and META analysis","authors":"Zhaoying Yan , Tao Zhang , Zifan Ding , Baole Tao , Junwen Shu , Minlei Yu , Qingyu Liang , Jun Yan","doi":"10.1016/j.ctim.2025.103237","DOIUrl":"10.1016/j.ctim.2025.103237","url":null,"abstract":"<div><h3>Background</h3><div>Elderly patients with Chronic Obstructive Pulmonary Disease (COPD) commonly suffer from anxiety, depression, and impaired health-related quality of life (HRQOL). This review evaluated the effects of mind-body exercises on these outcomes and exercise tolerance in COPD patients aged ≥ 60 years.</div></div><div><h3>Methods</h3><div>Following PRISMA guidelines, we systematically searched PubMed, Embase, PsycINFO, Cochrane Library, and Web of Science (inception-January 2025) for randomized controlled trials (RCTs) comparing mind-body exercise versus usual care. Outcomes were anxiety, depression, HRQOL (St. George's Respiratory Questionnaire or Chronic Respiratory Questionnaire), and exercise tolerance (6-minute walk test). Meta-analyses used random-effects models, reporting Standardized Mean Differences (SMDs) or Mean Differences (MDs) with 95 % confidence intervals (CIs). Evidence certainty was assessed (GRADE framework). Seventeen RCTs were included.</div></div><div><h3>Results</h3><div>Mind-body exercise reduced anxiety (SMD = −0.59, 95 % CI: −0.84 to −0.34; high certainty) and depression (SMD = −0.34, 95 % CI: −0.54 to −0.14; high certainty). HRQOL improved significantly (SMD = −0.79, 95 % CI: −1.14 to −0.44; low certainty), with exploratory findings showing greater improvement in Southeast Asian patients (SMD = −3.41). Exercise tolerance increased (MD = 44.23 m, 95 % CI: 26.12–62.34), exceeding minimal clinically important differences. Intervention duration for depression was a key moderator, with greater benefits in patients with interventions lasting ≥ 3080 min.</div></div><div><h3>Conclusion</h3><div>Mind-body exercise reduces anxiety and depression, improves health-related quality of life, and increases exercise tolerance in elderly patients with COPD. For anxiety and depression, benefits are significantly enhanced with intervention durations ≥ 3080 minutes. Incorporating mind-body exercise into comprehensive COPD management for older adults is recommended.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"93 ","pages":"Article 103237"},"PeriodicalIF":3.5,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144892784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-08-22DOI: 10.1016/j.ctim.2025.103230
Renhong Wan , Xiaorui Zeng , Yupeng Zhang , Haiyan Wang , Luqiang Sun , Shuai Chen , Fangli Luo , Yujun Hou , Qianhua Zheng , Ying Li
Background
Many patients with functional gastrointestinal disorders (FGIDs) seek complementary and alternative therapies to improve gastrointestinal (GI) symptoms. Research on the use of acupuncture to improve GI symptoms has been growing, but the results have been inconsistent.
Objective
To provide a systematic review and meta-analysis of the effectiveness of acupuncture-based treatment for FGIDs using the latest data and a rigorous evaluation system.
Method
We searched PubMed, Web of Science, Cochrane Library and EMBASE (OVID interface) databases for randomized controlled trials (RCTs) of acupuncture in the treatment of FGIDs from database creation to October 15, 2023. We collected data on GI symptoms and adverse events, and meta-analysis was performed using STATA 16 software. The risk of bias was evaluated using the Cochrane's risk of bias version 2 (RoB2) tool. The quality of evidence was evaluated with the Grading of Recommendations Assessment, Development and Evaluation approach.
Results
Twenty-nine RCTs involving 5100 participants were included. The results of meta-analysis showed that compared with sham acupuncture (RR 1.65, 95 %CI 1.35–2.03) and Western medication (RR 1.15, 95 %CI 1.07–1.23), acupuncture had a higher response rate, which was related to acupuncture frequency and treatment course. Compared with sham acupuncture or usual care, acupuncture significantly improved GI symptoms, including general symptoms (SMD 0.48, 95 % CI 0.25–0.72), stool trait (MD 0.50, 95 %CI 0.22–0.78) and dyspepsia score (MD 10.67, 95 %CI 4.88–16.47). Compared with Western medication, acupuncture only had an advantage in improving the general symptoms of GI (SMD 1.33, 95 %CI 0.93–1.73). No differences in adverse events were observed between acupuncture and sham acupuncture or Western medication. The overall certainty of the evidence ranged from very low to moderate.
Conclusions
Current evidence suggests that acupuncture may have a positive effect on improving GI symptoms in FGIDs, but further high-quality studies are required to validate its efficacy. The available evidence is limited by methodological flaws and potential biases in the included studies, resulting in an overall low quality of evidence. Therefore, the interpretation of these findings should be interpreted with caution.
{"title":"Potential benefit with acupuncture in functional gastrointestinal disorders: A systematic review and meta-analysis","authors":"Renhong Wan , Xiaorui Zeng , Yupeng Zhang , Haiyan Wang , Luqiang Sun , Shuai Chen , Fangli Luo , Yujun Hou , Qianhua Zheng , Ying Li","doi":"10.1016/j.ctim.2025.103230","DOIUrl":"10.1016/j.ctim.2025.103230","url":null,"abstract":"<div><h3>Background</h3><div>Many patients with functional gastrointestinal disorders (FGIDs) seek complementary and alternative therapies to improve gastrointestinal (GI) symptoms. Research on the use of acupuncture to improve GI symptoms has been growing, but the results have been inconsistent.</div></div><div><h3>Objective</h3><div>To provide a systematic review and meta-analysis of the effectiveness of acupuncture-based treatment for FGIDs using the latest data and a rigorous evaluation system.</div></div><div><h3>Method</h3><div>We searched PubMed, Web of Science, Cochrane Library and EMBASE (OVID interface) databases for randomized controlled trials (RCTs) of acupuncture in the treatment of FGIDs from database creation to October 15, 2023. We collected data on GI symptoms and adverse events, and meta-analysis was performed using STATA 16 software. The risk of bias was evaluated using the Cochrane's risk of bias version 2 (RoB2) tool. The quality of evidence was evaluated with the Grading of Recommendations Assessment, Development and Evaluation approach.</div></div><div><h3>Results</h3><div>Twenty-nine RCTs involving 5100 participants were included. The results of meta-analysis showed that compared with sham acupuncture (RR 1.65, 95 %CI 1.35–2.03) and Western medication (RR 1.15, 95 %CI 1.07–1.23), acupuncture had a higher response rate, which was related to acupuncture frequency and treatment course. Compared with sham acupuncture or usual care, acupuncture significantly improved GI symptoms, including general symptoms (SMD 0.48, 95 % CI 0.25–0.72), stool trait (MD 0.50, 95 %CI 0.22–0.78) and dyspepsia score (MD 10.67, 95 %CI 4.88–16.47). Compared with Western medication, acupuncture only had an advantage in improving the general symptoms of GI (SMD 1.33, 95 %CI 0.93–1.73). No differences in adverse events were observed between acupuncture and sham acupuncture or Western medication. The overall certainty of the evidence ranged from very low to moderate.</div></div><div><h3>Conclusions</h3><div>Current evidence suggests that acupuncture may have a positive effect on improving GI symptoms in FGIDs, but further high-quality studies are required to validate its efficacy. The available evidence is limited by methodological flaws and potential biases in the included studies, resulting in an overall low quality of evidence. Therefore, the interpretation of these findings should be interpreted with caution.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"93 ","pages":"Article 103230"},"PeriodicalIF":3.5,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144890470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
扫码关注我们
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号