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Effects of mindfulness meditation on blood pressure and quality of life in patients with intradialytic hypertension during haemodialysis: A randomised controlled trial 正念冥想对血液透析期间溶性高血压患者血压和生活质量的影响:一项随机对照试验。
IF 3.5 3区 医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2025-09-16 DOI: 10.1016/j.ctim.2025.103245
Yongyao Wu , Qiaojing Xia , Yiyi Gao , Chao Zhang , Pengjie Xu , Haojie Zhang , Gao Chao , Rizhen Yu , Jiang Liu

Objective

To investigate the effects of mindfulness meditation on blood pressure changes and quality of life in patients with intradialytic hypertension (IDH) during haemodialysis.

Methods

This single-blind, randomised controlled trial involved 69 patients with IDH undergoing maintenance haemodialysis at Lihuili Hospital in Ningbo, Zhejiang Province, China, between August and December 2024. Patients were randomly assigned to an intervention group (n = 34) receiving mindfulness meditation and a control group (n = 35) receiving standard care. Blood pressure and quality of life were measured at baseline and after 12 weeks.

Results

During haemodialysis, the intervention group exhibited significantly lower systolic, diastolic and mean arterial pressures, as well as pulse rate, than the control group (p < 0.001). Quality of life, assessed using the Kidney Disease Quality of Life Short Form 36, improved significantly in the intervention group across multiple dimensions, including physical function, role limitations due to physical problems, bodily pain, general health, energy/fatigue, emotional well-being and sleep (p < 0.05). However, no significant improvement was observed in social function (p > 0.05). Laboratory tests showed a significant reduction in serum homocysteine levels in the intervention group (p < 0.05). The incidence of adverse reactions was significantly lower in the intervention group (11.76 %) than in the control group (45.71 %, p < 0.05).

Conclusion

Mindfulness meditation can effectively improve IDH in patients undergoing haemodialysis and substantially enhance their quality of life. As a non-pharmacological intervention, mindfulness meditation is safe and easy to implement, offering a new therapeutic option for patients with IDH.

Trial Registration

ISRCTN82788940, Registration date: 29/10/2024
目的:探讨正念冥想对透析期高血压(IDH)患者血压变化及生活质量的影响。方法:这项单盲、随机对照试验于2024年8月至12月在中国浙江省宁波市丽丽丽医院接受维持性血液透析的69例IDH患者进行。患者被随机分配到接受正念冥想的干预组(n = 34)和接受标准治疗的对照组(n = 35)。在基线和12周后测量血压和生活质量。结果:在血液透析过程中,干预组患者的收缩压、舒张压、平均动脉压及脉搏率均显著低于对照组(p < 0.001)。使用肾脏疾病生活质量短表36评估,干预组的生活质量在多个维度上都有显著改善,包括身体功能、身体问题导致的角色限制、身体疼痛、一般健康、精力/疲劳、情绪健康和睡眠(p < 0.05)。然而,社会功能无明显改善(p < 0.05)。实验室检测显示干预组血清同型半胱氨酸水平显著降低(p < 0.05)。干预组不良反应发生率(11.76%)明显低于对照组(45.71%),p < 0.05。结论:正念冥想能有效改善血液透析患者的IDH,显著提高患者的生活质量。正念冥想作为一种非药物干预,安全易行,为IDH患者提供了一种新的治疗选择。试验注册号:ISRCTN82788940,注册日期:29/10/2024。
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引用次数: 0
Transcutaneous auricular vagus nerve stimulation for functional dyspepsia: A systematic review and meta-analysis 经皮耳迷走神经刺激治疗功能性消化不良:系统回顾和荟萃分析。
IF 3.5 3区 医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2025-09-16 DOI: 10.1016/j.ctim.2025.103243
Boram Lee , Chan-Young Kwon , Yoon Kyoung Jeong , Roberta Sclocco , Braden Kuo , Vitaly Napadow , Jun-Hwan Lee , Hojun Kim

Background

Transcutaneous auricular vagus nerve stimulation (taVNS) is a potential noninvasive treatment for functional dyspepsia (FD). We aimed to systematically analyze the clinical evidence of taVNS for FD.

Methods

Eight databases were searched to identify randomized controlled trials (RCTs) using taVNS in patients with FD published by June 27, 2024. The primary outcome was dyspepsia symptoms, whereas the secondary outcomes were the total effective rate (TER), quality of life, anxiety, depression, and incidence of adverse events. The certainty of the evidence was assessed using the GRADE methodology. Detailed information on the taVNS parameters and the suggested underlying mechanism were also extracted.

Results

Six RCTs with 716 participants were included. Compared to the sham intervention, taVNS significantly improved dyspepsia symptoms, quality of life, and clinician-rated anxiety and depression with moderate certainty of evidence. The TER based on dyspepsia symptoms was also significantly higher with high certainty of evidence. When taVNS was used as an add-on therapy, dyspepsia symptoms were significantly improved with moderate certainty of evidence. No serious adverse events related to taVNS were reported. The stimulation sites for taVNS were concha and tragus, with common pulse frequencies of 25 or 20 Hz twice a day for 2–4 weeks. Gastric accommodation, electrogastrogram, heart rate variability, and functional magnetic resonance imaging were measured to explore the mechanism of taVNS.

Conclusions

Considering the certainty of the evidence, taVNS can improve dyspepsia symptoms, quality of life, anxiety, and depression in patients with FD without serious adverse events. Additional high-quality studies are needed to establish optimal treatment protocols.
背景:经皮耳迷走神经刺激(taVNS)是一种潜在的无创治疗功能性消化不良(FD)的方法。我们旨在系统地分析taVNS治疗FD的临床证据。方法:检索8个数据库,以确定截至2024年6月27日发表的使用taVNS治疗FD患者的随机对照试验(rct)。主要结局是消化不良症状,而次要结局是总有效率(TER)、生活质量、焦虑、抑郁和不良事件发生率。使用GRADE方法评估证据的确定性。提取了taVNS参数的详细信息和可能的潜在机制。结果:纳入6项随机对照试验,共716名受试者。与假干预相比,taVNS显著改善了消化不良症状、生活质量和临床医生评定的焦虑和抑郁,证据具有中等确定性。基于消化不良症状的TER也明显更高,证据确定性高。当taVNS作为一种附加疗法使用时,消化不良症状得到了显著改善,证据具有中等确定性。未见与taVNS相关的严重不良事件。taVNS的刺激部位为耳甲和耳屏,脉冲频率为25或20Hz,每天2次,持续2 ~ 4周。通过胃调节功能、胃电图、心率变异性和功能磁共振成像来探讨taVNS的发生机制。结论:考虑到证据的确定性,taVNS可改善FD患者的消化不良症状、生活质量、焦虑和抑郁,无严重不良事件。需要更多的高质量研究来建立最佳的治疗方案。
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引用次数: 0
How important are meditation and spirituality in Reiki practice? 灵气练习中冥想和灵性有多重要?
IF 3.5 3区 医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2025-09-16 DOI: 10.1016/j.ctim.2025.103246
Ann Linda Baldwin , Vicky McLelland , Duncan Cross , Nicole Braveman

Objective

Meditation and spirituality can enhance the well-being of allopathic healthcare providers and the quality of care they deliver but little is known about holistic healers, such as Reiki practitioners. Two surveys were developed to ascertain whether Reiki practitioners routinely use meditative and spiritual disciplines to strengthen their practice.

Method

The surveys were promoted through email using Mailchimp and Facebook to all members of UK Reiki Federation (about 1800) and through several other Facebook groups with a global reach. An online survey tool, SurveyMonkey, was used to collect the survey data and MS Excel to analyze it.

Results

Most respondents were white, heterosexual females, middle aged or older, residing in the UK or USA, trained to Reiki Master level. Over one third were Christian and another third affiliated with various non-established beliefs. Most participants experienced a spiritual connection when they practiced Reiki, which opened them to a higher power, and they thought this connection enhanced their self-development. Seventy-nine percent believed that Reiki spirit guides provide personal guidance, support, and assistance. Ninety-five percent meditated weekly from one to seven times a week and most believed that meditation increased their connection and ability to channel, Reiki.

Conclusion

Most respondents to the surveys routinely use meditation and spiritual connection to strengthen their Reiki practice and enhance their ability to channel Reiki to patients or clients. This information may stimulate inclusion of meditation and spirituality in the training of holistic healthcare professionals and help them communicate more effectively with their clients.
目的:冥想和灵性可以提高对抗疗法医疗服务提供者的幸福感和他们提供的护理质量,但对整体治疗师,如灵气从业者知之甚少。研究人员进行了两项调查,以确定灵气练习者是否经常使用冥想和精神训练来加强他们的练习。方法:通过Mailchimp和Facebook的电子邮件向英国灵气联合会的所有成员(约1800人)以及其他几个具有全球影响力的Facebook小组推广调查。使用在线调查工具SurveyMonkey收集调查数据,并使用MS Excel进行分析。结果:大多数受访者为白人,异性恋女性,中年或以上,居住在英国或美国,接受过灵气大师水平的培训。超过三分之一的人是基督徒,另外三分之一的人隶属于各种非既定信仰。大多数参与者在练习灵气时都经历了一种精神上的联系,这为他们打开了更高的力量,他们认为这种联系促进了他们的自我发展。79%的人相信灵气精神向导提供个人指导、支持和帮助。95%的人每周冥想一到七次,大多数人认为冥想增加了他们的联系和沟通能力,灵气。结论:大多数调查对象经常使用冥想和精神连接来加强他们的灵气练习,提高他们向病人或客户传递灵气的能力。这些信息可能会刺激在整体医疗保健专业人员的培训中纳入冥想和灵性,并帮助他们更有效地与客户沟通。
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引用次数: 0
The impact of a breathing exercise program on pain, disability, and breathing patterns in patients with non-specific neck pain: A randomized controlled trial 呼吸运动项目对非特异性颈部疼痛患者疼痛、残疾和呼吸模式的影响:一项随机对照试验。
IF 3.5 3区 医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2025-09-16 DOI: 10.1016/j.ctim.2025.103244
Heon Heo , DooChul Shin

Background

Upper chest breathing patterns can increase accessory muscle activation and reduce cervical stability, contributing to neck pain

Objective

To examine the effects of a respiratory exercise program on pain, cervical range of motion, disability, breathing patterns, and muscular endurance in patients with non-specific neck pain.

Design

randomized controlled trial

Methods

Thirty-two patients with non-specific neck pain and upper chest breathing patterns were included. The study was conducted from July 19, 2021, to September 3, at a physical therapy center. Participants were randomly assigned to a breathing exercise (BE) or neck exercise (NE) group. Thermoelectric therapy, soft tissue relaxation, and thoracic spine mobilization were performed in both groups. The BE group performed breathing exercises, whereas the NE group performed general neck exercises. Pain intensity, neck disability index, cervical range of motion, breathing pattern, and deep cervical flexor endurance were measured before and after the intervention. Paired t-test and independent t-test compared pre- and post-test differences within and between groups.

Results

Both groups showed significant improvements in pain intensity and NDI (pain: BE vs NE mean difference 0.34, 95 % CI –0.25–0.93, p = .239; NDI: 0.86, 95 % CI –0.62–2.34, p = .249). Breathing pattern improved only in the BE group (mean difference 2.73, 95 % CI 1.78–3.68, p < .001). Endurance of deep cervical flexors increased in both groups, greater in NE (mean difference –15.98, 95 % CI –25.26 to –6.70, p = .010).

Conclusion

Breathing exercises improved breathing patterns in patients with non-specific neck pain, but effects on pain and disability were inconclusive.
背景:上胸部呼吸模式可增加副肌激活,降低颈椎稳定性,导致颈部疼痛。目的:研究呼吸锻炼方案对非特异性颈部疼痛患者疼痛、颈椎活动度、残疾、呼吸模式和肌肉耐力的影响。设计:随机对照试验方法:纳入32例非特异性颈部疼痛和上胸呼吸方式的患者。该研究于2021年7月19日至9月3日在物理治疗中心进行。参与者被随机分配到呼吸运动(BE)组或颈部运动(NE)组。两组均行热电治疗、软组织松弛、胸椎活动。BE组进行呼吸练习,而NE组进行一般的颈部练习。测量干预前后疼痛强度、颈部残疾指数、颈椎活动度、呼吸方式、颈深屈肌耐力。配对t检验和独立t检验比较组内和组间检验前后的差异。结果:两组疼痛强度和NDI均有显著改善(疼痛:BE vs NE平均差异0.34,95% CI -0.25 ~ 0.93, p= 0.239; NDI: 0.86, 95% CI -0.62 ~ 2.34, p= 0.249)。呼吸模式仅在BE组得到改善(平均差异2.73,95% CI 1.78至3.68)。结论:呼吸练习改善了非特异性颈部疼痛患者的呼吸模式,但对疼痛和残疾的影响尚无定论。
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引用次数: 0
Spirulina’s impacts on cardiovascular health: Insights from a systematic meta-analysis of RCT 螺旋藻对心血管健康的影响:来自随机对照试验系统荟萃分析的见解
IF 3.5 3区 医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2025-09-13 DOI: 10.1016/j.ctim.2025.103242
Hamidreza Shiri , Ali Akbar Soleimani , Behnam Omidi Sarajar , Abdolkarim Talebi Taheri , Fataneh Esmaeili , Mohammad Hadi Nematollahi , Mahmood Alizadeh Sani

Introduction

CVDs are considered the major public health concern and mortality in the world. Common treatments have some side effects and require low-risk treatments, such as herbal medicine. Spirulina is a filamentous microalga that has improved cardiometabolic parameters.

Methods

Systematic searches were conducted in Scopus, ISI Web of Science, and PubMed/Medline databases up to 20 January 2025 to identify RCTs based on the PRISMA checklist and PICOS criteria (People > 18 years, Intervention: spirulina, Comparison: placebo /control, Outcomes: TG, TC, LDL-C, HDL-C, FBG, HbA1c, insulin, HOMA-IR, SBP, DBP, BMI, weight, hs-CRP, IL-6, TNF-α, and Study: RCTs). Meta- analysis was utilized by random-effects models, and the GRADE criteria ensured the certainty of results.

Result

The results of 35 trials (45 effect sizes) show that spirulina intake improved glucose homeostasis (FBG; WMD: −5.51 (mg/dl); P = 0.001, HOMA-IR; WMD: −0.68; P < 0.001, and insulin; WMD: −0.86 (ng/ml); P = 0.002), decreased dyslipidemia (TG; WMD: −14.75 (mg/dl); P < 0.001, TC: WMD: −11.5 (mg/dl); P < 0.001, LDL-C; WMD: −7.69 (mg/dl); P < 0.001, and HDL-C; WMD: 1.9 (mg/dl); P < 0.001), decreased blood pressure (SBP; WMD: −3.85 mmHg, P = 0.002, and DBP; WMD: −3.09 mmHg, P < 0.001), reduced anthropometric indexes (weight; WMD: −1.78 kg; P = 0.003, and BMI; WMD: −0.58 kg/m²; P = 0.001), and decreased inflammation (TNF-α; WMD: −0.46 pg/ml; P = 0.01, IL-6; WMD: −0.58 pg/ml; P < 0.001, and hs-CRP; WMD: −0.86 mg/L; P = 0.002). Based on GRADE analysis, LDL-C, FBG, and HbA1c had of low quality, while the outcome for weight was of high quality. Furthermore, other parameters had moderate-quality outcomes.

Conclusion

This study demonstrates that spirulina supplementation effectively reduces the risk of CVD in adults by improving glucose homeostasis, dyslipidemia, blood pressure, anthropometric indexes, and inflammation. So, intake of spirulina is an adjunct or complementary to improve cardiometabolic profiles.

Trial registration

PROSPERO registration cod: (CRD42024626090)
心血管疾病被认为是世界上主要的公共卫生问题和死亡率。普通的治疗方法有一些副作用,需要低风险的治疗,比如草药。螺旋藻是一种丝状微藻,具有改善心脏代谢参数的作用。方法系统检索Scopus、ISI Web of Science和PubMed/Medline数据库,截至2025年1月20日,根据PRISMA检查表和PICOS标准(患者18岁,干预:螺旋藻,比较:安慰剂/对照,结局:TG、TC、LDL-C、HDL-C、FBG、HbA1c、胰岛素、HOMA-IR、收缩压、舒压、BMI、体重、hs-CRP、IL-6、TNF-α和研究:rct)确定rct。随机效应模型采用Meta分析,GRADE标准保证了结果的确定性。结果35项试验(45个效应量)的结果表明,螺旋藻摄入改善了葡萄糖稳态(FBG; WMD: - 5.51 (mg/dl);0.001 P = HOMA-IR;大规模杀伤性武器:−0.68;P <; 0.001,胰岛素;WMD:−0.86 (ng/ml);P = 0.002),降低血脂异常(TG; WMD:−14.75 (mg/dl);P <; 0.001,TC: WMD: - 11.5 (mg/dl);P & lt; 0.001,低密度;WMD:−7.69 (mg/dl);P <; 0.001,HDL-C;WMD: 1.9 (mg/dl);P & lt; 0.001),降低血压(SBP;大规模杀伤性武器:−3.85 mmHg, P = 0.002,和菲律宾;大规模杀伤性武器:−3.09 mmHg, P & lt; 0.001),降低人体测量指标(体重;大规模杀伤性武器:− 公斤1.78;P = 0.003,体重指数;大规模杀伤性武器:−0.58 公斤/ m²;P = 0.001),并降低炎症(TNF -α;大规模杀伤性武器:−0.46 pg / ml; P = 0.01,il - 6,大规模杀伤性武器:−0.58 pg / ml; P & lt; 0.001,和hs-CRP;大规模杀伤性武器:−0.86 mg / L; P = 0.002)。根据GRADE分析,LDL-C、FBG和HbA1c的结果质量较低,而体重的结果质量较高。此外,其他参数具有中等质量的结果。结论本研究表明,螺旋藻补充可通过改善葡萄糖稳态、血脂异常、血压、人体测量指标和炎症,有效降低成人心血管疾病的风险。因此,螺旋藻的摄入是一种辅助或补充,以改善心脏代谢谱。试用注册普洛斯佩罗注册编号:(CRD42024626090)
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引用次数: 0
From farm to bedside: Potential of medical cannabis in global health 从农场到床边:医用大麻在全球健康中的潜力
IF 3.5 3区 医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2025-09-10 DOI: 10.1016/j.ctim.2025.103205
Maureen Bilinga Tendwa , Tejaswini Appidi , Brylyne Chitsunge , Michele Moreau , Blessed Okole , Lonji Kalombo , Abba Mallum , Twalib Ngoma , Daniel P. Weadock , Eric Tanifum , Simon Erridge , Mikael Sodergren , Rob Sims , Calvin Johnson , Ngeh Toyang , Henry Lowe , Bashkim Ziberi , Luc Richner , Sandra Carrillo , Stephen Avery , Wilfred Ngwa

Introduction

The growing opioid crisis and persistent global health disparities underscore the urgent need for alternative therapeutic strategies. Cannabis, with its long-standing historical use and recent legislative developments, presents a potentially significant avenue for addressing these challenges. This review examines the evolving landscape of medicinal cannabis, drawing from historical ethnopharmacological data and contemporary scientific discussions.

Methods

This review synthesized evidence from historical ethnobotanical records, peer-reviewed studies, and outcomes derived from recent Global Health events. These events facilitated discussions among diverse stakeholders, including healthcare professionals, policymakers, researchers, industry representatives, farmers, and patient advocates. Case studies and successful models from the USA and Africa, including the recent FDA approval for first-in-human clinical trials of a medicinal cannabis derivative for pancreatic cancer, were analysed.

Results

Successful models include collaborative platforms fostering stakeholder engagement, such as partnerships between African farmers and biotech firms to standardize cultivation. Successful models demonstrate the potential for adaptation and scaling in diverse healthcare settings. The FDA trial approval exemplifies progress in clinical translation. However, disparities persist, with patients within Africa facing systemic barriers to medical Cannabis certification and higher rates of punitive opioid discontinuation.

Conclusion

Medicinal Cannabis presents a complex yet promising solution for reducing opioid-related mortality and addressing healthcare inequities. Implementing strategic frameworks like CORE (Care, Outreach, Research, Education) is essential for developing safe, high-quality, evidence-based cannabis products. Through fostering collaboration and addressing existing obstacles, the therapeutic potential of medicinal Cannabis can be harnessed to mitigate the opioid crisis and reduce global health disparities, effectively translating research from farm to bedside.
日益严重的阿片类药物危机和持续存在的全球健康差距强调了对替代治疗策略的迫切需要。大麻具有悠久的历史用途和最近的立法发展,为解决这些挑战提供了一个潜在的重要途径。本综述从历史民族药理学数据和当代科学讨论中考察了药用大麻的发展前景。方法本综述综合了历史民族植物学记录、同行评议研究和最近全球卫生事件的结果的证据。这些活动促进了不同利益相关者之间的讨论,包括医疗保健专业人员、政策制定者、研究人员、行业代表、农民和患者倡导者。分析了来自美国和非洲的案例研究和成功模式,包括最近FDA批准的用于胰腺癌的药用大麻衍生物的首次人体临床试验。成功的模式包括促进利益相关者参与的协作平台,例如非洲农民和生物技术公司之间的伙伴关系,以使种植标准化。成功的模型展示了在不同医疗保健环境中适应和扩展的潜力。FDA的试验批准体现了临床转化的进步。然而,差距仍然存在,非洲境内的患者在获得医用大麻认证方面面临系统性障碍,惩罚性阿片类药物停药率较高。结论药用大麻为减少阿片类药物相关死亡率和解决医疗不公平问题提供了一个复杂但有希望的解决方案。实施CORE(护理、外联、研究、教育)等战略框架对于开发安全、高质量、以证据为基础的大麻产品至关重要。通过促进合作和解决现有障碍,可以利用药用大麻的治疗潜力,减轻阿片类药物危机,缩小全球健康差距,有效地将研究从农场转化为床边。
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引用次数: 0
Hot spring and sauna use for improving blood lipid profiles: A systematic review and expert consensus on efficacy and recommendations 温泉和桑拿用于改善血脂谱:对功效和建议的系统评价和专家共识
IF 3.5 3区 医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2025-09-04 DOI: 10.1016/j.ctim.2025.103241
Satoshi Yamasaki , Tomotake Tokunou , Yusuke Kashiwado , Mari Makishi , Takahiko Horiuchi

Objectives

Dyslipidemia is a significant risk factor for cardiovascular disease. Traditional treatments often focus on pharmacological interventions; however, alternative therapies, such as hot spring and sauna use, have recently gained attention because of their potentially beneficial effects on lipid profiles and cardiovascular health.

Design and setting

This systematic review aimed to synthesize current evidence on the efficacy of hot spring and sauna use, alone or combined with exercise therapy, in improving blood lipid profiles, with a focus on mechanisms, benefits, and limitations.

Methods

The review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A search of 330 records across major databases identified 127 studies for blinded screening using Rayyan (a web-based application for conducting systematic reviews). Seven randomized controlled trials (RCTs) investigating the effects of hot spring and sauna use on lipid profiles in adults were included.

Results

Four RCTs in younger adults (mean age < 60 years) demonstrated that hot spring and sauna use resulted in reductions in serum total cholesterol and low-density lipoprotein cholesterol; these therapies were given a weak expert recommendation. Three RCTs in older adults (mean age ≥ 60 years) showed no significant blood lipid changes.

Conclusions

In younger adults, hot spring and sauna use, particularly when combined with exercise therapy, may contribute to improved lipid profiles. Emerging evidence from intervention studies could inform future guidelines for integrating these therapies into dyslipidemia management strategies.
目的:血脂异常是心血管疾病的重要危险因素。传统的治疗方法往往侧重于药物干预;然而,替代疗法,如温泉和桑拿的使用,最近引起了人们的关注,因为它们对血脂和心血管健康有潜在的有益影响。设计和背景本系统综述旨在综合目前有关温泉和桑拿单独使用或与运动疗法联合使用对改善血脂状况的有效性的证据,重点关注其机制、益处和局限性。方法本综述遵循系统评价和荟萃分析指南的首选报告项目。对主要数据库中的330项记录进行的搜索确定了127项使用Rayyan(用于进行系统评价的基于网络的应用程序)进行盲法筛选的研究。纳入了七项随机对照试验(rct),研究了温泉和桑拿对成人脂质谱的影响。结果4项针对年轻成人(平均年龄60岁)的随机对照试验表明,使用温泉和桑拿可降低血清总胆固醇和低密度脂蛋白胆固醇;这些疗法都没有得到专家的有力推荐。在老年人(平均年龄≥60岁)中,3项随机对照试验未发现明显的血脂变化。结论:在年轻人中,使用温泉和桑拿,特别是结合运动疗法,可能有助于改善血脂。来自干预研究的新证据可以为将这些疗法整合到血脂异常管理策略的未来指南提供信息。
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引用次数: 0
Corrigendum to “The efficacy of physical activity or exercise among individuals with cerebral palsy: An umbrella review of systematic reviews” [Complement Ther Med 93 (2025) 103228] “体力活动或锻炼对脑瘫患者的疗效:系统综述”的更正[补体医学93(2025)103228]。
IF 3.5 3区 医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2025-09-01 DOI: 10.1016/j.ctim.2025.103240
Majed M. Alhumaid , Faris Yahya I. Asiri , Mohamed A. Said , Justin A. Haegele
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引用次数: 0
The impact of neurolinguistic programming on anxiety, self-confidence, self-esteem, and performance in non-elite finswimmers 神经语言编程对非精英游泳运动员焦虑、自信、自尊和表现的影响
IF 3.5 3区 医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2025-08-26 DOI: 10.1016/j.ctim.2025.103239
Safa Saadani , Robert Jarai , Attila Szabo , Szilvia Boros

Background

Few studies have addressed mental health in finswimmers.

Objective

This study examines the effect of NLP used as mental training on the finswimmers’ anxiety, self-confidence, self-esteem, and swimming records.

Methods

The NLP intervention lasted two months. The study involved thirty young finswimmers (mean age M = 15.53, SD = 1.024), divided equally into two groups: the experimental and the control group. We carried out a pre- and post-test research design and conducted a follow-up test. We used two questionnaires, the French version of the CSAI-2R and the French version of the PSPP, along with semi-structured interviews for all three tests.

Results

In the post-intervention test, the experimental group significantly decreased their cognitive anxiety (β = −3.47, p < .001) and somatic anxiety (β = −2.20, p = .001). Significantly increased their self-confidence (β = 2.07, p < .001), their global self-esteem (β = 1.93, p = .002), and their physical self-worth (β = 2.13, p = .004). The same parameters, except for the global self-esteem, also recorded significant change in the follow-up test, p < .005. Time effect did not show significance in the body attractiveness, physical strength, physical conditioning, and sport competence. Furthermore, outcomes showed notable between-subject variability in the mental skills, suggesting substantial variability in baseline parameter levels between individuals. Consequently, the finswimmers enhanced their swimming records.

Conclusions

NLP showed a powerful impact in optimizing finswimmers’ mental health and, accordingly, their athletic performance. Besides, the technique showed relatively durable effectiveness. Coaches can reinforce the effect through ongoing NLP training.
很少有研究涉及游泳者的心理健康。目的探讨NLP作为心理训练对游泳运动员焦虑、自信、自尊和游泳成绩的影响。方法NLP干预持续2个月。研究对象为30名年轻的游泳运动员(平均年龄M = 15.53, SD = 1.024),平均分为实验组和对照组。我们进行了测试前和测试后的研究设计,并进行了跟踪测试。我们使用了两份问卷,法语版的CSAI-2R和法语版的PSPP,以及所有三个测试的半结构化访谈。结果干预后测试中,实验组认知焦虑显著降低(β = - 3.47, p <; )。001)和躯体焦虑(β =−2.20,p = .001)。显著提高自信心(β = 2.07, p <; )。001),他们的整体自尊(β = 1.93, p = )。002),身体自我价值感(β = 2.13, p = .004)。相同的参数,除了整体自尊,在后续测试中也记录了显著的变化,p <; .005。时间效应在身体吸引力、体力、体能和运动能力上均不显著。此外,结果显示受试者之间的心理技能存在显著差异,表明个体之间的基线参数水平存在显著差异。因此,游泳运动员提高了他们的游泳记录。结论单核苷酸多态性对改善游泳运动员的心理健康和运动成绩有显著影响。此外,该技术显示出相对持久的有效性。教练可以通过持续的NLP训练来强化这种效果。
{"title":"The impact of neurolinguistic programming on anxiety, self-confidence, self-esteem, and performance in non-elite finswimmers","authors":"Safa Saadani ,&nbsp;Robert Jarai ,&nbsp;Attila Szabo ,&nbsp;Szilvia Boros","doi":"10.1016/j.ctim.2025.103239","DOIUrl":"10.1016/j.ctim.2025.103239","url":null,"abstract":"<div><h3>Background</h3><div>Few studies have addressed mental health in finswimmers.</div></div><div><h3>Objective</h3><div>This study examines the effect of NLP used as mental training on the finswimmers’ anxiety, self-confidence, self-esteem, and swimming records.</div></div><div><h3>Methods</h3><div>The NLP intervention lasted two months. The study involved thirty young finswimmers (mean age M = 15.53, SD = 1.024), divided equally into two groups: the experimental and the control group. We carried out a pre- and post-test research design and conducted a follow-up test. We used two questionnaires, the French version of the CSAI-2R and the French version of the PSPP, along with semi-structured interviews for all three tests.</div></div><div><h3>Results</h3><div>In the post-intervention test, the experimental group significantly decreased their cognitive anxiety (β = −3.47, p &lt; .001) and somatic anxiety (β = −2.20, p = .001). Significantly increased their self-confidence (β = 2.07, p &lt; .001), their global self-esteem (β = 1.93, p = .002), and their physical self-worth (β = 2.13, p = .004). The same parameters, except for the global self-esteem, also recorded significant change in the follow-up test, p &lt; .005. Time effect did not show significance in the body attractiveness, physical strength, physical conditioning, and sport competence. Furthermore, outcomes showed notable between-subject variability in the mental skills, suggesting substantial variability in baseline parameter levels between individuals. Consequently, the finswimmers enhanced their swimming records.</div></div><div><h3>Conclusions</h3><div>NLP showed a powerful impact in optimizing finswimmers’ mental health and, accordingly, their athletic performance. Besides, the technique showed relatively durable effectiveness. Coaches can reinforce the effect through ongoing NLP training.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"93 ","pages":"Article 103239"},"PeriodicalIF":3.5,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144922180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparing the efficacy of combining ozone therapy with hyaluronic acid versus using hyaluronic acid alone for pain relief in patients with knee osteoarthritis: A randomized clinical trial 比较臭氧联合透明质酸治疗与单独使用透明质酸缓解膝关节骨关节炎患者疼痛的疗效:一项随机临床试验
IF 3.5 3区 医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2025-08-25 DOI: 10.1016/j.ctim.2025.103238
Ghodrat Akhavanakbari , Maryam Asayeshi , Reza Noktehsanj , Mohammad Reza Aslani

Background

There is growing interest in the therapeutic application of ozone (OZ) and hyaluronic acid (HA) for individuals suffering from osteoarthritis. This randomized trial aimed to assess the effectiveness of HA versus a mixture of OZ and HA in alleviating pain for patients diagnosed with OA.

Methods

In a double-blind clinical trial, 60 patients diagnosed with OA were randomly divided into two groups: One group was administered four intra-articular (IA) injections of hyaluronic acid (HA) every week (HA group), while the second group received the same frequency of injections but with ozone combined with HA (OZ+HA group). Patients underwent evaluations for pain levels utilizing the Visual Analogue Scale (VAS), assessed their quality of life with support from Health-Related Quality of Life (HRQL) metrics, and analyzed sleep quality using the Pittsburgh Sleep Quality Index (PSQI) at initial assessment and again at 2 weeks, 2 months, and 6 months following the intervention.

Results

Results indicated a significant decrease in the VAS-score value for both groups after six months of intervention, with the OZ + HA group experiencing a greater reduction (P < 0.001 for both). The HRQL value changes were significantly more pronounced in the OZ+HA group than in the HA group by the end of the study (P < 0.001). The decrease in the PSQI score in the OZ + HA group following six months of intervention was substantially less compared to the HA group (P < 0.001).

Conclusion

The combination of ozone and HA appears to have an enhancing effect on analgesic outcomes, sleep, and quality of life, indicating a need for further research.
臭氧(OZ)和透明质酸(HA)治疗骨关节炎的应用越来越受到关注。这项随机试验旨在评估透明质酸与混合透明质酸在缓解OA患者疼痛方面的有效性。方法采用双盲临床试验,将60例OA患者随机分为两组:一组患者每周给予4次关节内注射透明质酸(HA) (HA组),另一组患者给予相同注射频率但臭氧联合HA (OZ+HA组)。使用视觉模拟量表(VAS)对患者进行疼痛水平评估,在健康相关生活质量(HRQL)指标的支持下评估他们的生活质量,并在最初评估时使用匹兹堡睡眠质量指数(PSQI)分析睡眠质量,并在干预后2周、2个月和6个月再次进行评估。结果表明,干预6个月后,两组vas评分值均显著下降,其中OZ + HA组下降幅度更大(P <; 0.001)。研究结束时,OZ+HA组的HRQL值变化明显比HA组更明显(P <; 0.001)。干预六个月后,与HA组相比,OZ + HA组PSQI评分的下降幅度要小得多(P <; 0.001)。结论臭氧与透明质酸联用对镇痛效果、睡眠和生活质量有增强作用,有待进一步研究。
{"title":"Comparing the efficacy of combining ozone therapy with hyaluronic acid versus using hyaluronic acid alone for pain relief in patients with knee osteoarthritis: A randomized clinical trial","authors":"Ghodrat Akhavanakbari ,&nbsp;Maryam Asayeshi ,&nbsp;Reza Noktehsanj ,&nbsp;Mohammad Reza Aslani","doi":"10.1016/j.ctim.2025.103238","DOIUrl":"10.1016/j.ctim.2025.103238","url":null,"abstract":"<div><h3>Background</h3><div>There is growing interest in the therapeutic application of ozone (OZ) and hyaluronic acid (HA) for individuals suffering from osteoarthritis. This randomized trial aimed to assess the effectiveness of HA versus a mixture of OZ and HA in alleviating pain for patients diagnosed with OA.</div></div><div><h3>Methods</h3><div>In a double-blind clinical trial, 60 patients diagnosed with OA were randomly divided into two groups: One group was administered four intra-articular (IA) injections of hyaluronic acid (HA) every week (HA group), while the second group received the same frequency of injections but with ozone combined with HA (OZ+HA group). Patients underwent evaluations for pain levels utilizing the Visual Analogue Scale (VAS), assessed their quality of life with support from Health-Related Quality of Life (HRQL) metrics, and analyzed sleep quality using the Pittsburgh Sleep Quality Index (PSQI) at initial assessment and again at 2 weeks, 2 months, and 6 months following the intervention.</div></div><div><h3>Results</h3><div>Results indicated a significant decrease in the VAS-score value for both groups after six months of intervention, with the OZ + HA group experiencing a greater reduction (P &lt; 0.001 for both). The HRQL value changes were significantly more pronounced in the OZ+HA group than in the HA group by the end of the study (P &lt; 0.001). The decrease in the PSQI score in the OZ + HA group following six months of intervention was substantially less compared to the HA group (P &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>The combination of ozone and HA appears to have an enhancing effect on analgesic outcomes, sleep, and quality of life, indicating a need for further research.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"93 ","pages":"Article 103238"},"PeriodicalIF":3.5,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144925694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Complementary therapies in medicine
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