Pub Date : 2022-09-26DOI: 10.51910/ijhdr.v21i2.1213
Franscinne Brait Narita, C. Coelho, Bruna Scardoeli
Background: Hyperadrenocorticism is a common endocrinopathy in dogs, associated to an excessive production or administration of cortisol. Aims: Report the evolution of homeopathic treatment in hyperadrenocorticism of a yorkshire male dog with 10 years old, analyzing with basal and post-acth stimulation cortisol values. Methodology: Homeopathic treatment was chosen, based on the principle of similitude and because it is efficient and less harmful for the patient using Ignatia amara associated to cortisol biotherapy to inhibit cortisol production and adrenal biotherapy to stimulate the gland response. The exposed information is consented by the tutor. Results: The dog was in convencional treatment with trilostane but didn’t response to the therapy, showing 5,41 μg/dL of basal result and 11,8 μg/dL of post-acth result and the symptoms were worst on 12/12/2021, presenting lethargic, panting, more evident alopecia and severe muscle weakness which the patient unable to stand. Therefore, the protocol was recommended for 3 months, included 3 globules of Ignatia amara 30cH orally, every 12 hours, 3 globules of cortisol biotherapy 30 cH and also of adrenal biotherapy 6 cH every 24 hours for 30 days. On 03/28/2022 the basal and post-acth stimulation results was 3,71 μg/dL e 5,79 μg/dL respectively and the patient was more active, the skin was better and even with difficulty it was moving and having more independence. Conclusion: Homeopathic treatment with high dilution proved to be effective, keeping the indices with the recommended range of post acth between 2.0 and 5.0, confirming an adequate therapeutic monitoring and symptomatic improvement. Keywords: Homeopathy, Biotherapy, Hyperadrenocorticism, Cortisol References: Romão, F.G. et al. Hiperadrenocorticismo em cães: revisão. Clínica Veterinária, v. 91, 2011. Demarque, D.; Jouanny, J.; Poitevin, B.; Saint-Jean, Y. Farmacologia e Matéria Médica Homeopática. S. Paulo: Organon, 2009.
背景:肾上腺皮质亢进是一种常见的狗内分泌疾病，与皮质醇的过量产生或管理有关。目的:报告顺势疗法治疗一只10岁约克郡公犬肾上腺皮质亢进的进展，分析其基础和acth刺激后的皮质醇值。方法:选择顺势疗法治疗，基于相似的原则，因为它是有效的，对患者的危害较小，使用鸢尾花相关的皮质醇生物疗法来抑制皮质醇的产生和肾上腺生物疗法来刺激腺体反应。公开的信息已得到导师的同意。结果:犬经trilostane常规治疗后无反应，基础结果为5.41 μg/dL, acth后结果为11.8 μg/dL，于2021年12月12日症状最严重，表现为嗜睡、喘气，脱发更为明显，肌无力严重，无法站立。因此，该方案建议持续3个月，包括口服3粒黄芪30cH，每12小时一次，皮质醇生物疗法30cH 3粒，肾上腺生物疗法6ch每24小时一次，持续30天。2022年3月28日，acth基础和后刺激结果分别为3,71 μg/dL和5,79 μg/dL，患者更活跃，皮肤更好，甚至活动困难，独立性更强。结论:高稀释顺势疗法治疗有效，acth后指标保持在2.0 ~ 5.0推荐范围内，治疗监测充分，症状改善。关键词:顺势疗法，生物疗法，肾上腺皮质亢进，皮质醇参考文献:rom o, F.G.等。肾上腺皮质亢进症(英文):修订版。Clínica Veterinária, v. 91, 2011。Demarque d;茹阿尼,j .;Poitevin b;j . Saint-Jean, Y. Farmacologia e m.m.acriia m.m.acimica Homeopática。圣保罗:奥加纳，2009年。
{"title":"Hyperadrenocorticism Treatment with High Dilution – Case Report","authors":"Franscinne Brait Narita, C. Coelho, Bruna Scardoeli","doi":"10.51910/ijhdr.v21i2.1213","DOIUrl":"https://doi.org/10.51910/ijhdr.v21i2.1213","url":null,"abstract":"Background: Hyperadrenocorticism is a common endocrinopathy in dogs, associated to an excessive production or administration of cortisol. Aims: Report the evolution of homeopathic treatment in hyperadrenocorticism of a yorkshire male dog with 10 years old, analyzing with basal and post-acth stimulation cortisol values. Methodology: Homeopathic treatment was chosen, based on the principle of similitude and because it is efficient and less harmful for the patient using Ignatia amara associated to cortisol biotherapy to inhibit cortisol production and adrenal biotherapy to stimulate the gland response. The exposed information is consented by the tutor. Results: The dog was in convencional treatment with trilostane but didn’t response to the therapy, showing 5,41 μg/dL of basal result and 11,8 μg/dL of post-acth result and the symptoms were worst on 12/12/2021, presenting lethargic, panting, more evident alopecia and severe muscle weakness which the patient unable to stand. Therefore, the protocol was recommended for 3 months, included 3 globules of Ignatia amara 30cH orally, every 12 hours, 3 globules of cortisol biotherapy 30 cH and also of adrenal biotherapy 6 cH every 24 hours for 30 days. On 03/28/2022 the basal and post-acth stimulation results was 3,71 μg/dL e 5,79 μg/dL respectively and the patient was more active, the skin was better and even with difficulty it was moving and having more independence. Conclusion: Homeopathic treatment with high dilution proved to be effective, keeping the indices with the recommended range of post acth between 2.0 and 5.0, confirming an adequate therapeutic monitoring and symptomatic improvement. \u0000Keywords: Homeopathy, Biotherapy, Hyperadrenocorticism, Cortisol \u0000 \u0000References: \u0000Romão, F.G. et al. Hiperadrenocorticismo em cães: revisão. Clínica Veterinária, v. 91, 2011. \u0000Demarque, D.; Jouanny, J.; Poitevin, B.; Saint-Jean, Y. Farmacologia e Matéria Médica Homeopática. S. Paulo: Organon, 2009.","PeriodicalId":106057,"journal":{"name":"International Journal of High Dilution Research - ISSN 1982-6206","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121596613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-26DOI: 10.51910/ijhdr.v21i2.1209
Sandra Augusta Gordinho Pinto, Andreia Adelaide Gordinho Pinto
Carcinomas de glândula acrircrina são neoplasias malignas raras que ocorrem em gatos. O tratamento disponível é cirúrgico, e geralmente recorrente [1,2] e, neste caso, levaria à ablação total do meatus acústico externo. Em dezembro de 2020, foi relatada uma consulta homeopática do felino, masculino, persa, 13 anos, histórico da doença, iniciada em 2015, somando seis recidivas dos processos tumorais nas pálpebras e formação recente no canal auditivo esquerdo. Análise histopatológica do adenocarcinoma acritorino. Intervenções cirúrgicas e aplicação de ácido tricloroacético para prevenir recidivas. No entanto, foram observadas formações remanescentes nas pálpebras e no canal auditivo. Tem uma forma arredondada enevada na pálpebra superior direita medindo 0,4 cm e a inferior de 0,2 cm, redonda. No canal auditivo esquerdo, cerca de 1,6 cm, além de 4 pontos espalhados nas dobras auditivas. O tratamento homeopático foi iniciado por dois meses com o álbum Arsênico 30 cH, duas vezes ao dia; Carcinosinum 200 cH, uma vez por dia, e complexo contendo Avena sativa 4 cH, Echinacea angustifolia 4 cH, Conium maculatum 6 cH, Thuja officinalis 6 cH e Silicea terra 6 cH, quatro vezes ao dia. A cada dois meses, o quadro era reavaliado, poderes e frequências reajustados. Em poucos meses, houve remissão completa do tumor, recuperação do bem-estar e melhora no humor e apetite. O termo de consentimento livre e informado foi assinado. Não houve recidiva de tumores e cistite até março de 2022. Este estudo mostrou-se eficaz, documentado com fotos e exames. Abordar um caso raro pode fornecer uma nova possibilidade terapêutica. A credibilidade dos relatos de casos homeopáticos de qualidade vem aumentando devido às exigências metodológicas utilizando ferramentas desenvolvidas em estudos recentes. Tais critérios acabam extinguindo relatórios por não atingirem alta qualidade devido a variáveis não controláveis pelo pesquisador.
{"title":"Apocrine Gland Adenocarcinoma in a Persian Cat remission with homeopathic treatment: Case Report","authors":"Sandra Augusta Gordinho Pinto, Andreia Adelaide Gordinho Pinto","doi":"10.51910/ijhdr.v21i2.1209","DOIUrl":"https://doi.org/10.51910/ijhdr.v21i2.1209","url":null,"abstract":"Carcinomas de glândula acrircrina são neoplasias malignas raras que ocorrem em gatos. O tratamento disponível é cirúrgico, e geralmente recorrente [1,2] e, neste caso, levaria à ablação total do meatus acústico externo. Em dezembro de 2020, foi relatada uma consulta homeopática do felino, masculino, persa, 13 anos, histórico da doença, iniciada em 2015, somando seis recidivas dos processos tumorais nas pálpebras e formação recente no canal auditivo esquerdo. Análise histopatológica do adenocarcinoma acritorino. Intervenções cirúrgicas e aplicação de ácido tricloroacético para prevenir recidivas. No entanto, foram observadas formações remanescentes nas pálpebras e no canal auditivo. Tem uma forma arredondada enevada na pálpebra superior direita medindo 0,4 cm e a inferior de 0,2 cm, redonda. No canal auditivo esquerdo, cerca de 1,6 cm, além de 4 pontos espalhados nas dobras auditivas. O tratamento homeopático foi iniciado por dois meses com o álbum Arsênico 30 cH, duas vezes ao dia; Carcinosinum 200 cH, uma vez por dia, e complexo contendo Avena sativa 4 cH, Echinacea angustifolia 4 cH, Conium maculatum 6 cH, Thuja officinalis 6 cH e Silicea terra 6 cH, quatro vezes ao dia. A cada dois meses, o quadro era reavaliado, poderes e frequências reajustados. Em poucos meses, houve remissão completa do tumor, recuperação do bem-estar e melhora no humor e apetite. O termo de consentimento livre e informado foi assinado. Não houve recidiva de tumores e cistite até março de 2022. Este estudo mostrou-se eficaz, documentado com fotos e exames. Abordar um caso raro pode fornecer uma nova possibilidade terapêutica. A credibilidade dos relatos de casos homeopáticos de qualidade vem aumentando devido às exigências metodológicas utilizando ferramentas desenvolvidas em estudos recentes. Tais critérios acabam extinguindo relatórios por não atingirem alta qualidade devido a variáveis não controláveis pelo pesquisador.","PeriodicalId":106057,"journal":{"name":"International Journal of High Dilution Research - ISSN 1982-6206","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132949363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-26DOI: 10.51910/ijhdr.v21i2.1212
Franscinne Brait Narita, C. Coelho, Bruna Scardoeli
Background: Leukopenia is associated with the consumption of peripheral leukocytes, decreased production due to endotoxemia and septicemia, medullary hypoplasia, nutritional diseases or autoimmune reactions. In a case report by Narita et al, Echinacea angustifolia demonstrated the effectiveness of treatment of leukopenia in penguins. Aims: Report the evolution of homeopathic treatment in 5 dogs patients between 3 and 5 years old, presenting leukopenia. Methodology: The homeopathic treatment was chosen, based on the principle of similitude, using Echinacea angustifolia due to its immunostimulant action, that its evolution was analyzed by the blood test. The exposed information is consented by the tutors. Results: The same protocol was made for all of the patient, included 4 globules of Echinacea angustifolia 6 cH orally, every 12 hours for 30 days. The first dog attended on 07/21/2021, presented 4.000 leukocytes, which increased to 6.800 on 08/17/2021. The second patient attend on 12/07/2021 presented 4.700 leukocytes, increasing to 6.800 on 01/25/2022. The third patitent attended on 08/24/2021 presented 5.400 leukocyte, which increasing to 6.800 on 10/15/2021. The fourth patient presented 4.300 leukocytes on 01/13/2022, increasing to 5.500 on 02/11/2022. The fifth patient presented on 12/12/2021 4.600 leukocytes, increasing to 8.400 on 02/03/2022. Therefore, the mean of the first collection was 3.681 leukocytes and in the second there was a increased to 6.860 leukocytes (Mann Whitney, p= 0,0079). Conclusion: High dilution proves to be successful in the treatment of leukopenia without causing side effects. Keywords: Homeopathy, Leukopenia, Immunity, Dogs. References: Barnes, J.; Anderson, A.L.; Gibbons, S. Phillipson, D. Echinacea species (Echinacea angustifolia (DC.) Hell., Echinacea pallida (Nutt.) Nutt., Echinacea purpurea (L.) Moench): a review of their chemistry, pharmacology and clinical properties. Journal of Pharmacy and Pharmacology. V 57, 2005. Demarque, D.; Jouanny, J.; Poitevin, B.; Saint-Jean, Y. Farmacologia e Matéria Médica Homeopática. S. Paulo: Organon, 2009. Narita, F.; Scardoeli, B.; Bartalini, C.; Neto, H.; Coelho, C. Poster presentation - World Congress of Veterinary Homeopathy IAVH Colombia, Treatment of leukopenia with Echinacea angustifolia in Magellanic penguin (Spheniscus magellanicus), 2019.
背景:白细胞减少与外周白细胞消耗、内毒素血症和败血症、髓质发育不全、营养性疾病或自身免疫反应引起的白细胞生成减少有关。在Narita等人的病例报告中，紫锥菊证明了治疗企鹅白细胞减少症的有效性。目的:报告5例3 ~ 5岁的犬患者的顺势疗法治疗进展，表现为白细胞减少。方法:根据相似原理，选择具有免疫刺激作用的紫锥菊作为顺势疗法，并通过血检分析其演变过程。所披露的信息已得到导师的同意。结果:所有患者均采用相同的治疗方案，4粒紫锥菊6ch口服，每12小时一次，连用30天。第一只狗在2021年7月21日出现了4000个白细胞，到2021年8月17日增加到6800个。2021年7月12日第2例患者出现4700个白细胞，2022年1月25日增加到6800个。第三例患者于2021年8月24日就诊，白细胞为5400个，至2021年10月15日增加至6800个。第4例患者在2022年1月13日出现4300个白细胞，到2022年11月2日增加到5500个。第五例患者于2021年12月12日出现4600个白细胞，到2022年3月2日增加到8400个。因此，第一次采集的白细胞平均值为3.681个，第二次采集的白细胞平均值增加到6.860个(Mann Whitney, p= 0.0079)。结论:高稀释治疗白细胞减少症疗效显著，且无不良反应。关键词:顺势疗法，白细胞减少症，免疫，犬参考文献:Barnes, J.;安德森,A.L.;Gibbons, S. Phillipson, D.紫锥菊种(Echinacea angustifolia, DC.)地狱。紫锥菊(紫锥菊)纳特。紫锥菊(L.)综述了它们的化学、药理学和临床特性。药学与药理学杂志。V 57, 2005。Demarque d;茹阿尼,j .;Poitevin b;j . Saint-Jean, Y. Farmacologia e m.m.acriia m.m.acimica Homeopática。圣保罗:奥加纳，2009年。成田机场,f;Scardoeli b;Bartalini c;否决权,h;Coelho, C.海报展示-世界兽医顺势疗法大会哥伦比亚IAVH，麦哲伦企鹅(Spheniscus magellanicus)白细胞减少症治疗紫锥菊，2019。
{"title":"High Dilution in Leukopenia treatment in Dogs","authors":"Franscinne Brait Narita, C. Coelho, Bruna Scardoeli","doi":"10.51910/ijhdr.v21i2.1212","DOIUrl":"https://doi.org/10.51910/ijhdr.v21i2.1212","url":null,"abstract":"Background: Leukopenia is associated with the consumption of peripheral leukocytes, decreased production due to endotoxemia and septicemia, medullary hypoplasia, nutritional diseases or autoimmune reactions. In a case report by Narita et al, Echinacea angustifolia demonstrated the effectiveness of treatment of leukopenia in penguins. Aims: Report the evolution of homeopathic treatment in 5 dogs patients between 3 and 5 years old, presenting leukopenia. Methodology: The homeopathic treatment was chosen, based on the principle of similitude, using Echinacea angustifolia due to its immunostimulant action, that its evolution was analyzed by the blood test. The exposed information is consented by the tutors. Results: The same protocol was made for all of the patient, included 4 globules of Echinacea angustifolia 6 cH orally, every 12 hours for 30 days. The first dog attended on 07/21/2021, presented 4.000 leukocytes, which increased to 6.800 on 08/17/2021. The second patient attend on 12/07/2021 presented 4.700 leukocytes, increasing to 6.800 on 01/25/2022. The third patitent attended on 08/24/2021 presented 5.400 leukocyte, which increasing to 6.800 on 10/15/2021. The fourth patient presented 4.300 leukocytes on 01/13/2022, increasing to 5.500 on 02/11/2022. The fifth patient presented on 12/12/2021 4.600 leukocytes, increasing to 8.400 on 02/03/2022. Therefore, the mean of the first collection was 3.681 leukocytes and in the second there was a increased to 6.860 leukocytes (Mann Whitney, p= 0,0079). Conclusion: High dilution proves to be successful in the treatment of leukopenia without causing side effects. Keywords: Homeopathy, Leukopenia, Immunity, Dogs. \u0000References: \u0000Barnes, J.; Anderson, A.L.; Gibbons, S. Phillipson, D. Echinacea species (Echinacea angustifolia (DC.) Hell., Echinacea pallida (Nutt.) Nutt., Echinacea purpurea (L.) Moench): a review of their chemistry, pharmacology and clinical properties. Journal of Pharmacy and Pharmacology. V 57, 2005. \u0000Demarque, D.; Jouanny, J.; Poitevin, B.; Saint-Jean, Y. Farmacologia e Matéria Médica Homeopática. S. Paulo: Organon, 2009. \u0000Narita, F.; Scardoeli, B.; Bartalini, C.; Neto, H.; Coelho, C. Poster presentation - World Congress of Veterinary Homeopathy IAVH Colombia, Treatment of leukopenia with Echinacea angustifolia in Magellanic penguin (Spheniscus magellanicus), 2019.","PeriodicalId":106057,"journal":{"name":"International Journal of High Dilution Research - ISSN 1982-6206","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132573482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-26DOI: 10.51910/ijhdr.v21i2.1206
Thalia Adriane Rodrigues Gonçalves, Júlia Roriz de Oliveira
A common clinical occurrence in dogs is otitis externa caused by excessive growth of yeastsMalassezia pachydermatis, which can become chronic after wrong treatments, in which microbial resistance can occur. Homeopathic remedies can be considered a successful alternative, selecting the medicine through the similitude principle. Herein, 50 µL of a 1:1000 dilution of Malassezia pachydermatis suspension at 0.5 McFarland scale was used to seed the yeast into Sabouraud dextrose agar plates using a Drigalski spreader to proceed with colony unit counting. Before being seeded, the yeast suspensions were treated with 1% of different homeopathic treatments previously selected from a pilot study, which means Sulphur 6cH, Dolichos pruriens 6cH, and Kali carbonicum 6cH, being water, and succussed water used as controls. For comparison, a set of Sabouraud dextrose agar plates containing 1% Tween 80 was seeded in parallel. The treatments were made blind and evaluated in triplicate. Contaminated cultures were withdrawn. The number of colonies per plate was assessed, and smears were made from the cultures to classify yeast growth according to cytomorphology on ImageJ® software. The preliminary results show no significant effect of all tested medicines compared to the controls. High data variability was also observed, mainly in those cultures whose medium was prepared with Twin 80. In conclusion, at this point of the study, no evidence of the effects of the studied medicines on Malassezia pachydermatis growth invitro could be identified. The analysis of cytomorphology is still in course.
{"title":"Homeopathy Treatment of Malassezia Pachydermatis in vitro","authors":"Thalia Adriane Rodrigues Gonçalves, Júlia Roriz de Oliveira","doi":"10.51910/ijhdr.v21i2.1206","DOIUrl":"https://doi.org/10.51910/ijhdr.v21i2.1206","url":null,"abstract":"A common clinical occurrence in dogs is otitis externa caused by excessive growth of yeastsMalassezia pachydermatis, which can become chronic after wrong treatments, in which microbial resistance can occur. Homeopathic remedies can be considered a successful alternative, selecting the medicine through the similitude principle. Herein, 50 µL of a 1:1000 dilution of Malassezia pachydermatis suspension at 0.5 McFarland scale was used to seed the yeast into Sabouraud dextrose agar plates using a Drigalski spreader to proceed with colony unit counting. Before being seeded, the yeast suspensions were treated with 1% of different homeopathic treatments previously selected from a pilot study, which means Sulphur 6cH, Dolichos pruriens 6cH, and Kali carbonicum 6cH, being water, and succussed water used as controls. For comparison, a set of Sabouraud dextrose agar plates containing 1% Tween 80 was seeded in parallel. The treatments were made blind and evaluated in triplicate. Contaminated cultures were withdrawn. The number of colonies per plate was assessed, and smears were made from the cultures to classify yeast growth according to cytomorphology on ImageJ® software. The preliminary results show no significant effect of all tested medicines compared to the controls. High data variability was also observed, mainly in those cultures whose medium was prepared with Twin 80. In conclusion, at this point of the study, no evidence of the effects of the studied medicines on Malassezia pachydermatis growth invitro could be identified. The analysis of cytomorphology is still in course.","PeriodicalId":106057,"journal":{"name":"International Journal of High Dilution Research - ISSN 1982-6206","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114557653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-26DOI: 10.51910/ijhdr.v21i2.1214
Nathalia Salles Scortegagna de Medeiros
This is a case report of a feline injection-site sarcoma generated by the rabies vaccine in a 13 year old mix breed spay cat tretaed with isopathic medicine.
本文报告了一只13岁的混合品种喷淋猫注射狂犬病疫苗后产生的注射部位肉瘤的病例。
{"title":"Feline Injection-Site Sarcoma Complete Remission After Treatment with Isopathic medicine: a Case Report","authors":"Nathalia Salles Scortegagna de Medeiros","doi":"10.51910/ijhdr.v21i2.1214","DOIUrl":"https://doi.org/10.51910/ijhdr.v21i2.1214","url":null,"abstract":"This is a case report of a feline injection-site sarcoma generated by the rabies vaccine in a 13 year old mix breed spay cat tretaed with isopathic medicine. ","PeriodicalId":106057,"journal":{"name":"International Journal of High Dilution Research - ISSN 1982-6206","volume":"73 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124689117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-26DOI: 10.51910/ijhdr.v21i2.1211
A. Pinto, Mirian Y. Oliveira Nagai, Ednar Nascimento Coimbra, Suham Nowrooz Mohammad, Jefferson Souza Silva, Adalberto von Ancken, Sandra Augusta Gordinho Pinto, Michelle Sanchez Aguiar, M. DUTRA-CORREA, M. Hortellani, Adriana Miranda, J. E. Souza Sarkis, Ivana Barbosa Suffredini, Giovani Bravin Peres, M. Bernardi, S. Cartwright, Leoni Villano Bonamin
Isotherapics prepared from toxic substances have been described as attenuation factors for heavy metal intoxication in aquatic animals. Herein, Artemia salina and mercury chloride were used as a model to identify treatment-related bioresilience. The aim was to describe the effects of Mercurius corrosivus (MC) in different potencies on Artemia salina cyst hatching and on mercury bioavailability. Artemia salina cysts were exposed to 5.0 µg/mL of mercury chloride during the hatching phase. MC 6cH, 30cH, and 200cH were prepared and poured into artificial seawater. Different controls were used (nonchallenged cysts and challenged cysts treated with water, succussed water, and Ethilicum 1cH). Four series of nine experiments were performed for 4 weeks to evaluate the percentage of cyst hatching considering all moon phases. Soluble total mercury (THg) levels and precipitated mercury content were also evaluated. Solvatochromic dyes were used to check for eventual physicochemical markers of MC biological activity. Two-way analysis of variance (ANOVA) with mixed models was used for evaluating the effect of different treatments and the simultaneous influence of the moon phases on the cysts hatching rate, at both observation times (24 and 48 hours). When necessary, outliers were removed, using the Tukey criterion. The level of significance α was set at 5%. Significant delay (p<0.0001) in cyst hatching was observed after treatment with MC 30cH, compared with the controls. An increase in THg concentration in seawater (p<0.0018) and of chlorine/oxygen ratio (p<0.0001) in suspended micro-aggregates was also seen, with possible relation with mercury bioavailability. Specific interaction of MC 30cH with the solvatochromic dye ET33 (p<0.0017) was found. The other observed potencies of Mercurius corrosivus 6 and 200 cH were not significant in relation to the observed groups. The results were postulated as being protective effects of MC 30cH on Artemia salina, by improving its bioresilience.
{"title":"Mercury chloride toxicity attenuation of the Brine Shrimp Artemia Salina after treatment with Mercurius corrosivus as isotherapic","authors":"A. Pinto, Mirian Y. Oliveira Nagai, Ednar Nascimento Coimbra, Suham Nowrooz Mohammad, Jefferson Souza Silva, Adalberto von Ancken, Sandra Augusta Gordinho Pinto, Michelle Sanchez Aguiar, M. DUTRA-CORREA, M. Hortellani, Adriana Miranda, J. E. Souza Sarkis, Ivana Barbosa Suffredini, Giovani Bravin Peres, M. Bernardi, S. Cartwright, Leoni Villano Bonamin","doi":"10.51910/ijhdr.v21i2.1211","DOIUrl":"https://doi.org/10.51910/ijhdr.v21i2.1211","url":null,"abstract":" \u0000Isotherapics prepared from toxic substances have been described as attenuation factors for heavy metal intoxication in aquatic animals. Herein, Artemia salina and mercury chloride were used as a model to identify treatment-related bioresilience. The aim was to describe the effects of Mercurius corrosivus (MC) in different potencies on Artemia salina cyst hatching and on mercury bioavailability. Artemia salina cysts were exposed to 5.0 µg/mL of mercury chloride during the hatching phase. MC 6cH, 30cH, and 200cH were prepared and poured into artificial seawater. Different controls were used (nonchallenged cysts and challenged cysts treated with water, succussed water, and Ethilicum 1cH). Four series of nine experiments were performed for 4 weeks to evaluate the percentage of cyst hatching considering all moon phases. Soluble total mercury (THg) levels and precipitated mercury content were also evaluated. Solvatochromic dyes were used to check for eventual physicochemical markers of MC biological activity. Two-way analysis of variance (ANOVA) with mixed models was used for evaluating the effect of different treatments and the simultaneous influence of the moon phases on the cysts hatching rate, at both observation times (24 and 48 hours). When necessary, outliers were removed, using the Tukey criterion. The level of significance α was set at 5%. Significant delay (p<0.0001) in cyst hatching was observed after treatment with MC 30cH, compared with the controls. An increase in THg concentration in seawater (p<0.0018) and of chlorine/oxygen ratio (p<0.0001) in suspended micro-aggregates was also seen, with possible relation with mercury bioavailability. Specific interaction of MC 30cH with the solvatochromic dye ET33 (p<0.0017) was found. The other observed potencies of Mercurius corrosivus 6 and 200 cH were not significant in relation to the observed groups. The results were postulated as being protective effects of MC 30cH on Artemia salina, by improving its bioresilience.","PeriodicalId":106057,"journal":{"name":"International Journal of High Dilution Research - ISSN 1982-6206","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129021163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-25DOI: 10.51910/ijhdr.v21icf.1181
M. Wassenhoven, B. Nysten, Martine Goyens, P. Dorfman, P. Devos, D. Magnin
Background: Homeopathy is highly controversial. The main reason for this is its use of very highly dilute medicines (high homeopathic potencies, HHP), diluted beyond the Avogadro/Loschmidt limit. Research using Nano Tracking Analysis has demonstrated the presence of particles in HHPs. This study aims to verify the results of a previous publication that identified the ionic composition of these particles in all dilutions. Methods: We used Scanning Electron Microscopy & Energy Dispersive X-Ray Spectroscopy (SEM-EDX) to examine dilutions of a commonly used homeopathic medicine, an insoluble metal, Cuprum metallicum, for the presence of particles (NPs). The homeopathic medicines tested were specially prepared according to the European pharmacopoeia standards. We compared the homeopathic dilutions/dynamizations of copper with simple dilutions and dynamized lactose controls. Results: We observed an ionic diversity common to all preparations including HHPs but also significant differences in the relative quantity of each ion between manufacturing lines of homeopathic copper and lactose controls. The probability that the observed differences could have occurred chance alone (especially above Avogadro limit) can be rejected at p < 0.001. The essential component of these homeopathic medicines is sodium hydrogen carbonate, modulated by some other elements and by its quantity, size and shape. Conclusion: Homeopathic medicines made of Cuprum metallicum do contain material with a specific ionic composition even in HHPs diluted beyond the Avogadro/Loschmidt limit. This specificity can be attributed to the manufacturing process. This material demonstrates that the step-by-step process (dynamized or not) does not match the theoretical expectations of a dilution process. The starting material and dilution/dynamization method influences the nature of these NPs. Further measurements are needed on other raw materials using the same controls (solvent and simply diluted manufacturing lines) to support these findings. The role of sodium bicarbonate must be carefully studied in the future.
{"title":"Ion Partition Detected in Homeopathically Manufactured Medicine Cuprum metallicum and Controls","authors":"M. Wassenhoven, B. Nysten, Martine Goyens, P. Dorfman, P. Devos, D. Magnin","doi":"10.51910/ijhdr.v21icf.1181","DOIUrl":"https://doi.org/10.51910/ijhdr.v21icf.1181","url":null,"abstract":"Background: Homeopathy is highly controversial. The main reason for this is its use of very highly dilute medicines (high homeopathic potencies, HHP), diluted beyond the Avogadro/Loschmidt limit. Research using Nano Tracking Analysis has demonstrated the presence of particles in HHPs. This study aims to verify the results of a previous publication that identified the ionic composition of these particles in all dilutions. \u0000Methods: We used Scanning Electron Microscopy & Energy Dispersive X-Ray Spectroscopy (SEM-EDX) to examine dilutions of a commonly used homeopathic medicine, an insoluble metal, Cuprum metallicum, for the presence of particles (NPs). The homeopathic medicines tested were specially prepared according to the European pharmacopoeia standards. We compared the homeopathic dilutions/dynamizations of copper with simple dilutions and dynamized lactose controls. \u0000Results: We observed an ionic diversity common to all preparations including HHPs but also significant differences in the relative quantity of each ion between manufacturing lines of homeopathic copper and lactose controls. The probability that the observed differences could have occurred chance alone (especially above Avogadro limit) can be rejected at p < 0.001. The essential component of these homeopathic medicines is sodium hydrogen carbonate, modulated by some other elements and by its quantity, size and shape. \u0000Conclusion: Homeopathic medicines made of Cuprum metallicum do contain material with a specific ionic composition even in HHPs diluted beyond the Avogadro/Loschmidt limit. This specificity can be attributed to the manufacturing process. This material demonstrates that the step-by-step process (dynamized or not) does not match the theoretical expectations of a dilution process. The starting material and dilution/dynamization method influences the nature of these NPs. Further measurements are needed on other raw materials using the same controls (solvent and simply diluted manufacturing lines) to support these findings. The role of sodium bicarbonate must be carefully studied in the future.","PeriodicalId":106057,"journal":{"name":"International Journal of High Dilution Research - ISSN 1982-6206","volume":"87 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126186927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-12DOI: 10.51910/ijhdr.v21icf.1140
H. Ponnam
Background & Objectives: Psychological fragility caused to human life has been the largest aftermath of the pandemic posing a raised public health concern globally. This psychological impact is identified as Post-Traumatic Stress Disorder (PTSD) which was the most commonly diagnosed psychological disorder during this pandemic. These cases, if left untreated and unidentified may take a devastating transformation into psychotic disorders and cause gross damage to the individual and the community by disrupting human relations. Keeping in view the beneficial role of Homoeopathy in dealing with psychological disorders based on its philosophy and previous studies, a clinical case series of 10 PTSD cases successfully treated with Homoeopathy during this pandemic are presented here. Method: 10 cases of PTSD consulted during the first wave of pandemic diagnosed based on the clinical picture analogous to PTSD cluster symptomatology from Diagnostic and Statistical Manual of Mental Disorders-5 (DSM-5) and objectively through Clinician-Administered PTSD Scale for DSM-5 (CAPS-5) were treated with Homoeopathic intervention. Homeopathic medicine was prescribed based on the totality of each case through repertorization and in consultation with the sourcebooks of Homoeopathic Materia Medica (HMM). The cases were followed monthly for clinical improvement and every three months using the CAPS-5 score. The outcome was assessed after six months clinically and objectively through the CAPS-5 score. At the end of one year, further to assess the casual attribution of clinical outcome to homoeopathic intervention, validated MONARCH (Modified Naranjo Criteria for Homoeopathy) tool was utilized. Results: The 10 diagnosed PTSD cases showed marked improvement assessed after one year of Homoeopathic treatment. Significant improvement was found in the clinical picture affirmed through CAPS-5 score and MONARCH tool. Conclusion: Homoeopathic medicines showed a significantly beneficial role in the management of PTSD during the pandemic in the presented 10 cases. Further validation through well-designed clinical trials is warranted.
{"title":"Optimization of Homoeopathy in the management of Post-Traumatic Stress Disorder, the aftermath of COVID-19 pandemic: Clinical Case Series","authors":"H. Ponnam","doi":"10.51910/ijhdr.v21icf.1140","DOIUrl":"https://doi.org/10.51910/ijhdr.v21icf.1140","url":null,"abstract":"Background & Objectives: Psychological fragility caused to human life has been the largest aftermath of the pandemic posing a raised public health concern globally. This psychological impact is identified as Post-Traumatic Stress Disorder (PTSD) which was the most commonly diagnosed psychological disorder during this pandemic. These cases, if left untreated and unidentified may take a devastating transformation into psychotic disorders and cause gross damage to the individual and the community by disrupting human relations. Keeping in view the beneficial role of Homoeopathy in dealing with psychological disorders based on its philosophy and previous studies, a clinical case series of 10 PTSD cases successfully treated with Homoeopathy during this pandemic are presented here. \u0000Method: 10 cases of PTSD consulted during the first wave of pandemic diagnosed based on the clinical picture analogous to PTSD cluster symptomatology from Diagnostic and Statistical Manual of Mental Disorders-5 (DSM-5) and objectively through Clinician-Administered PTSD Scale for DSM-5 (CAPS-5) were treated with Homoeopathic intervention. Homeopathic medicine was prescribed based on the totality of each case through repertorization and in consultation with the sourcebooks of Homoeopathic Materia Medica (HMM). The cases were followed monthly for clinical improvement and every three months using the CAPS-5 score. The outcome was assessed after six months clinically and objectively through the CAPS-5 score. At the end of one year, further to assess the casual attribution of clinical outcome to homoeopathic intervention, validated MONARCH (Modified Naranjo Criteria for Homoeopathy) tool was utilized. \u0000Results: The 10 diagnosed PTSD cases showed marked improvement assessed after one year of Homoeopathic treatment. Significant improvement was found in the clinical picture affirmed through CAPS-5 score and MONARCH tool. \u0000Conclusion: Homoeopathic medicines showed a significantly beneficial role in the management of PTSD during the pandemic in the presented 10 cases. Further validation through well-designed clinical trials is warranted.","PeriodicalId":106057,"journal":{"name":"International Journal of High Dilution Research - ISSN 1982-6206","volume":"124 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124628557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-25DOI: 10.51910/ijhdr.v21icf.1120
E.R. Vinitha
Budd-Chiari syndrome [BCS] is a rare, potentially life-threatening condition characterized by the triad of abdominal pain, ascites, and hepatomegaly (with or without jaundice). There will be an underlying disorder in most cases. The diagnosis, as well as management of the case, requires a multidisciplinary approach. The treatment should aim at reducing the presenting symptoms as well as removing the underlying pathology. Here we explain a case report of a 21-year-old male patient in the subacute stage of BCS with its complications and considered as a candidate for liver transplantation. His liver enzymes, PT/INR, D- dimer, and homocysteine values were above normal levels. The arterial oxygen saturation level was subnormal, and he was on supportive oxygen supplement. Inferior venacava [IVC] Doppler revealed a non-obstructive intrahepatic thrombus. The patient was treated with Homoeopathic medicine Arsenicum album and Arnica montana, given as an adjuvant to conventional treatment.
{"title":"A case report of Budd-Chiari syndrome with cardiac complications and low SpO2 successfully managed by an Integrated-approach","authors":"E.R. Vinitha","doi":"10.51910/ijhdr.v21icf.1120","DOIUrl":"https://doi.org/10.51910/ijhdr.v21icf.1120","url":null,"abstract":"Budd-Chiari syndrome [BCS] is a rare, potentially life-threatening condition characterized by the triad of abdominal pain, ascites, and hepatomegaly (with or without jaundice). There will be an underlying disorder in most cases. The diagnosis, as well as management of the case, requires a multidisciplinary approach. The treatment should aim at reducing the presenting symptoms as well as removing the underlying pathology. Here we explain a case report of a 21-year-old male patient in the subacute stage of BCS with its complications and considered as a candidate for liver transplantation. His liver enzymes, PT/INR, D- dimer, and homocysteine values were above normal levels. The arterial oxygen saturation level was subnormal, and he was on supportive oxygen supplement. Inferior venacava [IVC] Doppler revealed a non-obstructive intrahepatic thrombus. The patient was treated with Homoeopathic medicine Arsenicum album and Arnica montana, given as an adjuvant to conventional treatment.","PeriodicalId":106057,"journal":{"name":"International Journal of High Dilution Research - ISSN 1982-6206","volume":"81 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127721041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-03DOI: 10.51910/ijhdr.v21icf.1153
N. Sukul, Sumit Ghosh, R. Singh, N. Pande, A. Sukul
High dilutions (HD) of drugs used in homeopathy are mostly too dilute to contain original drug molecules. But evidences support their specific biological and therapeutic effects. The reason behind this is thought to be water structure characteristic of the original drug. Spectroscopic studies indicate that the specific water structure in HDs can be resolved into free water molecules, hydrogen bonding strength of water hydroxyl, number of hydrogen bonds and clathrate hydrate crystals (CHC). HDs are prepared in EtOH water solution by serial dilution and mechanical agitation, and are called potencies. The objective of the present study is to further confirm the presence of CHCs in the two potencies of three drugs. Electronic spectra of the HDs of the potencies indicate two broad peaks and marked difference in intensities of absorption. Furior Transform Infrared (FT-IR) spectra of the test potencies and their control show difference in intensity shift and contour shape of OH stretching and bending bands. All the experimental data indicate the presence of CHCs in varying amounts in the test potencies.
{"title":"Investigation of the Influence of clathrate hydrate crystals on the Structuring of Homeopathic High Dilutions","authors":"N. Sukul, Sumit Ghosh, R. Singh, N. Pande, A. Sukul","doi":"10.51910/ijhdr.v21icf.1153","DOIUrl":"https://doi.org/10.51910/ijhdr.v21icf.1153","url":null,"abstract":"High dilutions (HD) of drugs used in homeopathy are mostly too dilute to contain original drug molecules. But evidences support their specific biological and therapeutic effects. The reason behind this is thought to be water structure characteristic of the original drug. Spectroscopic studies indicate that the specific water structure in HDs can be resolved into free water molecules, hydrogen bonding strength of water hydroxyl, number of hydrogen bonds and clathrate hydrate crystals (CHC). HDs are prepared in EtOH water solution by serial dilution and mechanical agitation, and are called potencies. The objective of the present study is to further confirm the presence of CHCs in the two potencies of three drugs. Electronic spectra of the HDs of the potencies indicate two broad peaks and marked difference in intensities of absorption. Furior Transform Infrared (FT-IR) spectra of the test potencies and their control show difference in intensity shift and contour shape of OH stretching and bending bands. All the experimental data indicate the presence of CHCs in varying amounts in the test potencies.","PeriodicalId":106057,"journal":{"name":"International Journal of High Dilution Research - ISSN 1982-6206","volume":"108 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134142232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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