Pub Date : 2022-07-03DOI: 10.51910/ijhdr.v21icf.1127
Gyandas Wadhwani, Aditi Chadha
Background: Since the initiation of vaccine rollout, breakthrough COVID-19 infections have been reported. While conventional therapy is the accepted mode of treatment, there has been little recognition of the role played by the alternative therapies like homeopathy. The purposes of this study were to identify the clinico-symptomatic profile of the vaccine breakthrough covid-19 infections and to assess the response of individualized homoeopathic treatment in these breakthrough cases. Methods: A retrospective data analysis of patients treated with homoeopathic medicines who confirmed the breakthrough infection criteria: positive infection ≥14 days after completion of both the recommended doses of an authorized COVID-19 vaccine was conducted. IBM SPSS Statistics 21.0 was used for data analysis with a p-value below 0.05 defined as significant. WHO Clinical Progression Scale and Outcome in Relation to Impact on Daily Living score were used as outcome measures. Results: In total 73 cases were reported to be vaccine breakthrough infections. The median recovery time reported in the data set was 9 ± 2 days. While 5 patients dropped out, 68 (93.15%) patients responded positively to homeopathic treatment, and 55 (75.34%) recovered completely with normalized serological markers/ nasal swabs/ HRCT Chest. About 29 (39.72%) of these presented with mild clinical manifestations, 26 (35.61%) moderate, 17 (23.28%) severe and 1 (1.36%) was critical. 10 homeopathic remedies were prescribed to these 73 patients. Majority of the patients attained an ORIDL score of 4. Maximum patients reported a WHO clinical Progression score of 3. Statistical analysis showed a significant response to homeopathic treatment in the study group. Conclusion: Vaccine breakthrough cases occur in a fraction of vaccinated people. Despite the limited number of study subjects, homoeopathy showed some promising results in the present setup. The response rate was highest in the moderate and severe cases which suggest the importance of consideration of alternative medicine in the current pandemic. Further exploratory research studies and comparative clinical trials may be encouraged.
{"title":"Observations on 73 Vaccine breakthrough COVID-19 infected patients and its individualized homeopathic treatment","authors":"Gyandas Wadhwani, Aditi Chadha","doi":"10.51910/ijhdr.v21icf.1127","DOIUrl":"https://doi.org/10.51910/ijhdr.v21icf.1127","url":null,"abstract":"Background: Since the initiation of vaccine rollout, breakthrough COVID-19 infections have been reported. While conventional therapy is the accepted mode of treatment, there has been little recognition of the role played by the alternative therapies like homeopathy. The purposes of this study were to identify the clinico-symptomatic profile of the vaccine breakthrough covid-19 infections and to assess the response of individualized homoeopathic treatment in these breakthrough cases. \u0000Methods: A retrospective data analysis of patients treated with homoeopathic medicines who confirmed the breakthrough infection criteria: positive infection ≥14 days after completion of both the recommended doses of an authorized COVID-19 vaccine was conducted. IBM SPSS Statistics 21.0 was used for data analysis with a p-value below 0.05 defined as significant. WHO Clinical Progression Scale and Outcome in Relation to Impact on Daily Living score were used as outcome measures. \u0000Results: In total 73 cases were reported to be vaccine breakthrough infections. The median recovery time reported in the data set was 9 ± 2 days. While 5 patients dropped out, 68 (93.15%) patients responded positively to homeopathic treatment, and 55 (75.34%) recovered completely with normalized serological markers/ nasal swabs/ HRCT Chest. About 29 (39.72%) of these presented with mild clinical manifestations, 26 (35.61%) moderate, 17 (23.28%) severe and 1 (1.36%) was critical. 10 homeopathic remedies were prescribed to these 73 patients. Majority of the patients attained an ORIDL score of 4. Maximum patients reported a WHO clinical Progression score of 3. Statistical analysis showed a significant response to homeopathic treatment in the study group. \u0000Conclusion: Vaccine breakthrough cases occur in a fraction of vaccinated people. Despite the limited number of study subjects, homoeopathy showed some promising results in the present setup. The response rate was highest in the moderate and severe cases which suggest the importance of consideration of alternative medicine in the current pandemic. Further exploratory research studies and comparative clinical trials may be encouraged.","PeriodicalId":106057,"journal":{"name":"International Journal of High Dilution Research - ISSN 1982-6206","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128326806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-19DOI: 10.51910/ijhdr.v21icf.1141
Aditya Dilipkumar Patil
The curriculum in academic medicine is defined by writing effective Learning objectives (LO). LO is elaborated based on perceptions of unbiased written aspects, of course, the rationale in statements is explained and tested through the completion of educational activity. These are the foundations for defining the outcomes in building up strong educational policies which are instructional aligned through predefined effective curriculum courses with added mapped outcomes. This letter provides the ongoing aspect of the development of Homoeopathic education in India regulated by the National Commission for Homoeopathy for the subject course of Advance Teaching of Fundamentals of Homoeopathy (ATFH). The essential components for the ATFHsubject course with LO and outcome assessment is been discussed and would provide a new arena of academic research in building up rationale in the programed [Doctor of Homoeopathy(MD,(Hom))].
{"title":"Advance Teaching of Fundamentals of Homoeopathy (ATFH): Redefining Competency Based Approach.","authors":"Aditya Dilipkumar Patil","doi":"10.51910/ijhdr.v21icf.1141","DOIUrl":"https://doi.org/10.51910/ijhdr.v21icf.1141","url":null,"abstract":"The curriculum in academic medicine is defined by writing effective Learning objectives (LO). LO is elaborated based on perceptions of unbiased written aspects, of course, the rationale in statements is explained and tested through the completion of educational activity. These are the foundations for defining the outcomes in building up strong educational policies which are instructional aligned through predefined effective curriculum courses with added mapped outcomes. This letter provides the ongoing aspect of the development of Homoeopathic education in India regulated by the National Commission for Homoeopathy for the subject course of Advance Teaching of Fundamentals of Homoeopathy (ATFH). The essential components for the ATFHsubject course with LO and outcome assessment is been discussed and would provide a new arena of academic research in building up rationale in the programed [Doctor of Homoeopathy(MD,(Hom))].","PeriodicalId":106057,"journal":{"name":"International Journal of High Dilution Research - ISSN 1982-6206","volume":"63 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134118134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-06DOI: 10.51910/ijhdr.v21i1.1176
A. P. Oliveira, Mary Lannes Salles Leite, Fortune Honsani, Juliana P Paiva, Rafael Tritany, C. Holandino
Background The most common way of consuming nicotine is in tobacco cigarettes. Nicotine causes intense addiction. The National Cancer Institute coordinates and executes the Tobacco Control Program in Brazil, through actions that encourage the adoption of healthier lifestyles. In this context, homeopathy has used Heteroisotherapic medicines formulated according to the homeopathic pharmaceutical technology with scientific evidence of efficacy in the detoxification of substances and metals, and in the desensitization of foods or medicines. Aims Promote the importance of the cognitive-behavioral approach in combination with the homeopathic treatment against smoking. Methodology In the initial phase of the randomized double-blind clinical study (CEP / HUCFF / UFRJ 65622916.2.0000.5257), the effectiveness of the 6CH heteroisotherapeutic drug was assessed. Volunteers were recruited and in-person welcoming meetings, using the cognitive-behavioral approach, were carried out to inform them about the risks of smoking and the benefits of quitting. In addition, they were supported and guided during the smoking cessation process so that they could deal with the withdrawal syndrome, the psychological dependence and the constraints associated with smoking. Results and discussion 84 participants were selected according to the inclusion criteria, and divided by randomization into two groups: the Test Group (heteroisotherapeutic medication) and the Control Group (homeopathic medication Nux vomica 6CH). Both groups will be followed for 12 months. The combination of the following approaches has led to a significant increase in the cessation rate: I. Prepare the smoker for solving his own issues; II. Stimulate skills to resist temptations to smoke; III. Prepare to prevent relapse; IV. Prepare to deal with stress. Studies show that, regardless the duration of these approaches, there is an increase in the abstinence rate. Moreover, the longer the total approach time (frequency multiplied by the time spent on each contact), the higher the abstinence rate. On the other hand, from a total approach time of 90 minutes on, there is no further increase in the abstinence rate. Conclusion The partial results obtained so far demonstrate that the cognitive-behavioral approach played a decisive role in the groups performance, favoring the treatment adherence as well as the group cohesion around the Project's objective, contributing to the effectiveness of the medicine, a decreased anxiety, improved sleep, cessation or decrease in the number of cigarettes smoked per day and the abstinence rate.
{"title":"Heteroisotherapics effect on the treatment against smoking: a cognitive-behavioral approach","authors":"A. P. Oliveira, Mary Lannes Salles Leite, Fortune Honsani, Juliana P Paiva, Rafael Tritany, C. Holandino","doi":"10.51910/ijhdr.v21i1.1176","DOIUrl":"https://doi.org/10.51910/ijhdr.v21i1.1176","url":null,"abstract":"Background The most common way of consuming nicotine is in tobacco cigarettes. Nicotine causes intense addiction. The National Cancer Institute coordinates and executes the Tobacco Control Program in Brazil, through actions that encourage the adoption of healthier lifestyles. In this context, homeopathy has used Heteroisotherapic medicines formulated according to the homeopathic pharmaceutical technology with scientific evidence of efficacy in the detoxification of substances and metals, and in the desensitization of foods or medicines. Aims Promote the importance of the cognitive-behavioral approach in combination with the homeopathic treatment against smoking. Methodology In the initial phase of the randomized double-blind clinical study (CEP / HUCFF / UFRJ 65622916.2.0000.5257), the effectiveness of the 6CH heteroisotherapeutic drug was assessed. Volunteers were recruited and in-person welcoming meetings, using the cognitive-behavioral approach, were carried out to inform them about the risks of smoking and the benefits of quitting. In addition, they were supported and guided during the smoking cessation process so that they could deal with the withdrawal syndrome, the psychological dependence and the constraints associated with smoking. Results and discussion 84 participants were selected according to the inclusion criteria, and divided by randomization into two groups: the Test Group (heteroisotherapeutic medication) and the Control Group (homeopathic medication Nux vomica 6CH). Both groups will be followed for 12 months. The combination of the following approaches has led to a significant increase in the cessation rate: I. Prepare the smoker for solving his own issues; II. Stimulate skills to resist temptations to smoke; III. Prepare to prevent relapse; IV. Prepare to deal with stress. Studies show that, regardless the duration of these approaches, there is an increase in the abstinence rate. Moreover, the longer the total approach time (frequency multiplied by the time spent on each contact), the higher the abstinence rate. On the other hand, from a total approach time of 90 minutes on, there is no further increase in the abstinence rate. Conclusion The partial results obtained so far demonstrate that the cognitive-behavioral approach played a decisive role in the groups performance, favoring the treatment adherence as well as the group cohesion around the Project's objective, contributing to the effectiveness of the medicine, a decreased anxiety, improved sleep, cessation or decrease in the number of cigarettes smoked per day and the abstinence rate.","PeriodicalId":106057,"journal":{"name":"International Journal of High Dilution Research - ISSN 1982-6206","volume":"76 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115088169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-06DOI: 10.51910/ijhdr.v21i1.1171
S. Mohammad, A. Pinto, M. Nagai, E. Coimbra, I. Suffredini, G. Peres, M. Bernardi, L. Bonamin
Introduction: Different environmental conditions can influence the effects of toxic agents on living beings. Recently, a series of experiments performed in Artemia salina submitted to different kinds of intoxication have shown that both, isotherapic and succussed water can change Artemia salina´s bio resilience at different levels. Moreover, it seems to vary according to the circalunar cycle. Objective: To verify if circalunar phases and water agitation can modify the toxicity of lead chloride on Artemia salina in vitro. Methodology: Artemia salina cysts were exposed to seawater containing 0.04% of lead chloride (equal to EC10 or 10% effective concentration, previously determined in a pilot study) in 96-well culture plates. Thirty-six experimental repetitions were performed in four series to observe the possible effects of adding stirred water, the so-called succussed water, and the moon phases. The hatched cysts were recorded after 48 hours using a digital microscope (1000x magnification) to identify the hatching percentage and the viability and mobility of the born nauplii. Results: The exposition of cysts to PbCl2 led to an increase in the hatching rate, and it was more evident during the full moon (p = 0.00014) The addition of succussed water into the seawater medium reduced this effect to the baseline levels. An increase in mobility was seen in nauplii born from exposed cysts during the full moon (p = 0.00077), but this effect was not affected by the treatment with succussed water. Discussion: Although the effects of lead chloride EC10 on the increase of nauplii hatching were expected, two environmental variables changed the sensitivity of cysts to this harmful stimulus. The circalunar cycle varied the hatching rate according to the moon phase, even in laboratory conditions, and the addition of succussed water into the medium reduced the hatching rate, even with different intensities according to the moon phase. The organization of nano and microbubbles generated after the succussion of water could be related to this protective effect and can explain, at least partially the effects of high diluted preparations on this biological context. Conclusion: Environmental factors, such as the circalunar cycle and products of water agitation, can modulate the adaptative control of hatching in Artemia salina exposed to lead chloride at EC10.
{"title":"Environmental parameters modulate lead chloride toxicity on Artemia salina","authors":"S. Mohammad, A. Pinto, M. Nagai, E. Coimbra, I. Suffredini, G. Peres, M. Bernardi, L. Bonamin","doi":"10.51910/ijhdr.v21i1.1171","DOIUrl":"https://doi.org/10.51910/ijhdr.v21i1.1171","url":null,"abstract":"Introduction: Different environmental conditions can influence the effects of toxic agents on living beings. Recently, a series of experiments performed in Artemia salina submitted to different kinds of intoxication have shown that both, isotherapic and succussed water can change Artemia salina´s bio resilience at different levels. Moreover, it seems to vary according to the circalunar cycle. Objective: To verify if circalunar phases and water agitation can modify the toxicity of lead chloride on Artemia salina in vitro. Methodology: Artemia salina cysts were exposed to seawater containing 0.04% of lead chloride (equal to EC10 or 10% effective concentration, previously determined in a pilot study) in 96-well culture plates. Thirty-six experimental repetitions were performed in four series to observe the possible effects of adding stirred water, the so-called succussed water, and the moon phases. The hatched cysts were recorded after 48 hours using a digital microscope (1000x magnification) to identify the hatching percentage and the viability and mobility of the born nauplii. Results: The exposition of cysts to PbCl2 led to an increase in the hatching rate, and it was more evident during the full moon (p = 0.00014) The addition of succussed water into the seawater medium reduced this effect to the baseline levels. An increase in mobility was seen in nauplii born from exposed cysts during the full moon (p = 0.00077), but this effect was not affected by the treatment with succussed water. Discussion: Although the effects of lead chloride EC10 on the increase of nauplii hatching were expected, two environmental variables changed the sensitivity of cysts to this harmful stimulus. The circalunar cycle varied the hatching rate according to the moon phase, even in laboratory conditions, and the addition of succussed water into the medium reduced the hatching rate, even with different intensities according to the moon phase. The organization of nano and microbubbles generated after the succussion of water could be related to this protective effect and can explain, at least partially the effects of high diluted preparations on this biological context. Conclusion: Environmental factors, such as the circalunar cycle and products of water agitation, can modulate the adaptative control of hatching in Artemia salina exposed to lead chloride at EC10.","PeriodicalId":106057,"journal":{"name":"International Journal of High Dilution Research - ISSN 1982-6206","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122288640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-06DOI: 10.51910/ijhdr.v21i1.1183
Mônica Filomena de Assis Souza, W. Santos, J. K. Valentim, R. G. Garcia, M. Burbarelli, F. C. Serpa, G. A. Felix, Gabriella Galvão Pizarini Nascimento, Bruna de Souza Eberhart, Pedro Henrique de Souza Cucco, M. Cucco, K. B. Brum
Introduction: The purpose of this trial was to assess the influence of homeopathy products on the diet of quails based on egg quality when submitted to different storage periods. Methodology: Two hundred, 45 day old Japanese quails and 80% of production were used, in a completely randomized design comprised of a 4x3 factorial, and 4 diets (basal feed, inert vehicle and 2 homeopathic products: Fertsigo® (Sulphur 10 CH, Sepia 15CH ) and Ovosigo® (Belladonna 12CH,Silicea 12 CH, Natrum mur. 30CH, Calcarea phos. 30CH, Sulphur 12CH) and 3 storage periods (0 days, 7 days and 14 days) with ten repetitions of three eggs per treatment. The weight, percentages of yoke, albumen and shell, albumen height and yolk color, specific gravity, Haugh unit, yolk index and shell thickness were evaluated. The data were submitted to variance analysis to verify whether there was a interaction effect between homeopathy factors and storage time, and when absent, the isolated effects. Results: An interaction between the homeopathic products and time was found for the parameters of albumen height and yolk, Haugh unit and yolk index, which reduced over time. For egg weight, yolk, albumen and shell, a significant effect (p<0.05) was found only in the case of homeopathy for the percentages of albumen and shell. For egg and albumen weights, yolk and albumen percentages, specific gravity and colorimetry there was an effect for time, however these parameters reduced over the storage time in days. The addition of the homeopathic based products Ovosigo® and FertSigo® are indicated for the diets of Japanese quail during the laying phase since it resulted in better weights for the egg and its components. Conclusion: The different homeopathic products did not have an influence on conserving the quality of the Japanese quail eggs during the periods evaluated.
{"title":"Influence of homeopathy on the quality of quail eggs stored for different periods of time","authors":"Mônica Filomena de Assis Souza, W. Santos, J. K. Valentim, R. G. Garcia, M. Burbarelli, F. C. Serpa, G. A. Felix, Gabriella Galvão Pizarini Nascimento, Bruna de Souza Eberhart, Pedro Henrique de Souza Cucco, M. Cucco, K. B. Brum","doi":"10.51910/ijhdr.v21i1.1183","DOIUrl":"https://doi.org/10.51910/ijhdr.v21i1.1183","url":null,"abstract":"Introduction: The purpose of this trial was to assess the influence of homeopathy products on the diet of quails based on egg quality when submitted to different storage periods. Methodology: Two hundred, 45 day old Japanese quails and 80% of production were used, in a completely randomized design comprised of a 4x3 factorial, and 4 diets (basal feed, inert vehicle and 2 homeopathic products: Fertsigo® (Sulphur 10 CH, Sepia 15CH ) and Ovosigo® (Belladonna 12CH,Silicea 12 CH, Natrum mur. 30CH, Calcarea phos. 30CH, Sulphur 12CH) and 3 storage periods (0 days, 7 days and 14 days) with ten repetitions of three eggs per treatment. The weight, percentages of yoke, albumen and shell, albumen height and yolk color, specific gravity, Haugh unit, yolk index and shell thickness were evaluated. The data were submitted to variance analysis to verify whether there was a interaction effect between homeopathy factors and storage time, and when absent, the isolated effects. Results: An interaction between the homeopathic products and time was found for the parameters of albumen height and yolk, Haugh unit and yolk index, which reduced over time. For egg weight, yolk, albumen and shell, a significant effect (p<0.05) was found only in the case of homeopathy for the percentages of albumen and shell. For egg and albumen weights, yolk and albumen percentages, specific gravity and colorimetry there was an effect for time, however these parameters reduced over the storage time in days. The addition of the homeopathic based products Ovosigo® and FertSigo® are indicated for the diets of Japanese quail during the laying phase since it resulted in better weights for the egg and its components. Conclusion: The different homeopathic products did not have an influence on conserving the quality of the Japanese quail eggs during the periods evaluated.","PeriodicalId":106057,"journal":{"name":"International Journal of High Dilution Research - ISSN 1982-6206","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129552378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-06DOI: 10.51910/ijhdr.v21i1.1174
T. Nader, Camila Yamasita Henrique, A. Leonel, A. Pereira
Background: The method of preserving substances of natural origin should not only maintain the microbiological safety of the product but also the integrity of its therapeutic potential. Essential oils obtained from plants are complex mixtures of substances and it is suggested to keep them under refrigeration for better conservation. On the other hand, homeopathic mother tincture prepared from plant is kept at room temperature. Aim: This work aimed to evaluate if the freezing process changes the in vitro antifungal activity potential of the homeopathic preparation Aloysia polystachya 1CH against Candida albicans. Methodology: The inoculum of C. albicans ATCC 10231 was cultivated in culture médium Sabouroud (Himedia®), standardized on a spectrometer and distributed in a 96-well plate. Then, A. polystachya 1CH was added to the wells, prepared according to the Brazilian Homeopathic Pharmacopoeia (FHB, 3rd edition) from A. polystachya essencial oil. An aliquot of this homeopathic preparation was frozen and after 40 days it was submitted to the same methodology for evaluation of the antifungal activity. After incubation, the plates were read with triphenyltetrazolic (TTC) (Vetec®). Results and discussion: The results of the in vitro evaluation showed that the freezing process retained the antifungal activity of the dynamized essential oil of A. polystachya 1CH against C. albicans. Conclusion: Under the conditions evaluated in this study, the freezing method presented as a viable method of conservation of dynamized plant material.
{"title":"Evaluation of the in vitro fungicidal activity of the dynamized essential oil of Aloysia polystachya before and after freezing","authors":"T. Nader, Camila Yamasita Henrique, A. Leonel, A. Pereira","doi":"10.51910/ijhdr.v21i1.1174","DOIUrl":"https://doi.org/10.51910/ijhdr.v21i1.1174","url":null,"abstract":"Background: The method of preserving substances of natural origin should not only maintain the microbiological safety of the product but also the integrity of its therapeutic potential. Essential oils obtained from plants are complex mixtures of substances and it is suggested to keep them under refrigeration for better conservation. On the other hand, homeopathic mother tincture prepared from plant is kept at room temperature. Aim: This work aimed to evaluate if the freezing process changes the in vitro antifungal activity potential of the homeopathic preparation Aloysia polystachya 1CH against Candida albicans. Methodology: The inoculum of C. albicans ATCC 10231 was cultivated in culture médium Sabouroud (Himedia®), standardized on a spectrometer and distributed in a 96-well plate. Then, A. polystachya 1CH was added to the wells, prepared according to the Brazilian Homeopathic Pharmacopoeia (FHB, 3rd edition) from A. polystachya essencial oil. An aliquot of this homeopathic preparation was frozen and after 40 days it was submitted to the same methodology for evaluation of the antifungal activity. After incubation, the plates were read with triphenyltetrazolic (TTC) (Vetec®). Results and discussion: The results of the in vitro evaluation showed that the freezing process retained the antifungal activity of the dynamized essential oil of A. polystachya 1CH against C. albicans. Conclusion: Under the conditions evaluated in this study, the freezing method presented as a viable method of conservation of dynamized plant material.","PeriodicalId":106057,"journal":{"name":"International Journal of High Dilution Research - ISSN 1982-6206","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131473848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-06DOI: 10.51910/ijhdr.v21i1.1170
Mônica Filomena de Assis Souza, Kácio Gomes Macedo, David Junior de Oliveira Pereira, Graciela Andreia Flis Machado, L. V. S. Barbosa, Larissa Wolff Gonçalves, Pedro Henrique de Souza Cucco, M. Cucco, K. B. Brum
Background: Homeopathy is a technique approved by the MAPA for organic production systems. Experiments demonstrating the effectiveness of homeopathy in agriculture are essential. Aims: To evaluate the effects of homeopathic treatment on soybean seed germination. Methodology: The experiment was performed in MS-Brazil. An area of 70 m² was used, divided into two comparison plots of 30 m² each. The soil of plot 1 (treated group) was treated with 5.25 kg of powdered Lithothamnium mixed with 250 ml of 30% hydroalcoholic solution (HS) containing homeopathic ingredients. The soil of plot 2 (control group) was treated with the same preparation but without homeopathic ingredients. Additionally, the 400 seeds assigned toplot 1 were treated with 0,3 ml of a solution made up of 10 ml of 30% HS with homeopathic ingredients diluted in 300 ml of water. The 400 seeds assigned toplot 2 were treated with 0.3 ml of a solution made up of 10 ml of HS without homeopathic ingredients diluted in 300 ml of water. The homeopathic ingredients Sulph 9C, Mag-c 12C, and Calc-p 9C were used on soil and seed treatment. The selection and prescription of those ingredients followed Materia Medica instructions. The experiment was conducted using randomized design and 400 seeds per group were sown. Results and discussion: In plot 1, an average of 11 seeds per m² germinated, adding up to 330 germinated seeds at a percentage of 82.5%. In plot 2, an average of 7 seeds per m² germinated, adding up to 210 germinated seeds at a percentage of 52.5%. The frequency of seed germination in both groups was assessed by the Chi-square test to check for significant differences (p<0.05). There was a statistical difference (p<0.05) in the seed germination in the treated group (n=330) compared to the control group (n=210). Conclusion: Homeopathic compounds can be used as a viable treatment for soybean germination.
{"title":"Effect of homeopathy on soybean germination through soil and seed treatment","authors":"Mônica Filomena de Assis Souza, Kácio Gomes Macedo, David Junior de Oliveira Pereira, Graciela Andreia Flis Machado, L. V. S. Barbosa, Larissa Wolff Gonçalves, Pedro Henrique de Souza Cucco, M. Cucco, K. B. Brum","doi":"10.51910/ijhdr.v21i1.1170","DOIUrl":"https://doi.org/10.51910/ijhdr.v21i1.1170","url":null,"abstract":"Background: Homeopathy is a technique approved by the MAPA for organic production systems. Experiments demonstrating the effectiveness of homeopathy in agriculture are essential. Aims: To evaluate the effects of homeopathic treatment on soybean seed germination. Methodology: The experiment was performed in MS-Brazil. An area of 70 m² was used, divided into two comparison plots of 30 m² each. The soil of plot 1 (treated group) was treated with 5.25 kg of powdered Lithothamnium mixed with 250 ml of 30% hydroalcoholic solution (HS) containing homeopathic ingredients. The soil of plot 2 (control group) was treated with the same preparation but without homeopathic ingredients. Additionally, the 400 seeds assigned toplot 1 were treated with 0,3 ml of a solution made up of 10 ml of 30% HS with homeopathic ingredients diluted in 300 ml of water. The 400 seeds assigned toplot 2 were treated with 0.3 ml of a solution made up of 10 ml of HS without homeopathic ingredients diluted in 300 ml of water. The homeopathic ingredients Sulph 9C, Mag-c 12C, and Calc-p 9C were used on soil and seed treatment. The selection and prescription of those ingredients followed Materia Medica instructions. The experiment was conducted using randomized design and 400 seeds per group were sown. Results and discussion: In plot 1, an average of 11 seeds per m² germinated, adding up to 330 germinated seeds at a percentage of 82.5%. In plot 2, an average of 7 seeds per m² germinated, adding up to 210 germinated seeds at a percentage of 52.5%. The frequency of seed germination in both groups was assessed by the Chi-square test to check for significant differences (p<0.05). There was a statistical difference (p<0.05) in the seed germination in the treated group (n=330) compared to the control group (n=210). Conclusion: Homeopathic compounds can be used as a viable treatment for soybean germination.","PeriodicalId":106057,"journal":{"name":"International Journal of High Dilution Research - ISSN 1982-6206","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133609774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-06DOI: 10.51910/ijhdr.v21i1.1188
C. Coelho, Marco Aurélio Gonçalves Manzoli, Rafael Acordi Santos, Elaine Bido, H. C. Vieira
Background: Mercury is used in various industrial. Part of Mercury's industrial waste is discharged into the environment, rivers and their tributaries, thus contaminating aquatic animals. Aim: to evaluate Mercury-induced behavioral changes in Zebrafish (Danio rerio) by the analysis of locomotor activity and parameters related to neurotoxicity and to verify whether ultra-diluted substances can decrease neurobehavioral effects and toxic. Methodology: The fishes were separated into 4 monitoring aquariums with 8 fishes each, with temperature, pH controlled, until the time of the toxicological experiments. 0.5 mL of Mercury 6cH, 30cH and distilled water (positive control) were added per liter of water in each aquarium containing 6 liters of water, then 3 mL of medication per aquarium, the white control received no medication and the toxic agent. After 1 hour the drugs were added, toxic mercury (200 μg/L), 4 mL per aquarium was added and remained so for 24 hours. All the experiment was run in blind, and the drugs identified by codes. The animals were subjected to behavioral tests (Open Field-locomotion; Vertical Open Field for neurotoxicity evaluation and Light and Dark Test), and each stage was recorded for later evaluation of movements and neurobehavioral changes. ANOVA was performed, followed by Tukey test, with p <0.05. Results: Mercury produced an anxiogenic effect in animals that were submitted to it without medication. In the vertical open field, there was an increase in erratic movements (1.25 ± 1.0) and tremors (0.87 ± 0.35) compared to the control (0.12 ± 0.35 and 0.25 ± 0.46 respectively), proving the toxic effect. Fishes which received the medication at 6 cH and 30 ch showed tremors and erratic movements similar to control. Conclusion: 200 μg/L mercury in water can cause neurobehavioral disturbances in fishes, and animals receiving Mercurius 6 cH and 30 cH ultra-diluted drug did not show neurotoxicity.
{"title":"Neurobehavioral assessment of Danio rerio intoxicated by Mercury and the use of Mercurius solubilis","authors":"C. Coelho, Marco Aurélio Gonçalves Manzoli, Rafael Acordi Santos, Elaine Bido, H. C. Vieira","doi":"10.51910/ijhdr.v21i1.1188","DOIUrl":"https://doi.org/10.51910/ijhdr.v21i1.1188","url":null,"abstract":"Background: Mercury is used in various industrial. Part of Mercury's industrial waste is discharged into the environment, rivers and their tributaries, thus contaminating aquatic animals. Aim: to evaluate Mercury-induced behavioral changes in Zebrafish (Danio rerio) by the analysis of locomotor activity and parameters related to neurotoxicity and to verify whether ultra-diluted substances can decrease neurobehavioral effects and toxic. Methodology: The fishes were separated into 4 monitoring aquariums with 8 fishes each, with temperature, pH controlled, until the time of the toxicological experiments. 0.5 mL of Mercury 6cH, 30cH and distilled water (positive control) were added per liter of water in each aquarium containing 6 liters of water, then 3 mL of medication per aquarium, the white control received no medication and the toxic agent. After 1 hour the drugs were added, toxic mercury (200 μg/L), 4 mL per aquarium was added and remained so for 24 hours. All the experiment was run in blind, and the drugs identified by codes. The animals were subjected to behavioral tests (Open Field-locomotion; Vertical Open Field for neurotoxicity evaluation and Light and Dark Test), and each stage was recorded for later evaluation of movements and neurobehavioral changes. ANOVA was performed, followed by Tukey test, with p <0.05. Results: Mercury produced an anxiogenic effect in animals that were submitted to it without medication. In the vertical open field, there was an increase in erratic movements (1.25 ± 1.0) and tremors (0.87 ± 0.35) compared to the control (0.12 ± 0.35 and 0.25 ± 0.46 respectively), proving the toxic effect. Fishes which received the medication at 6 cH and 30 ch showed tremors and erratic movements similar to control. Conclusion: 200 μg/L mercury in water can cause neurobehavioral disturbances in fishes, and animals receiving Mercurius 6 cH and 30 cH ultra-diluted drug did not show neurotoxicity.","PeriodicalId":106057,"journal":{"name":"International Journal of High Dilution Research - ISSN 1982-6206","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125850007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-06DOI: 10.51910/ijhdr.v21i1.1167
Vânia Emerich Bucco Campos, HA Pinheiro, Andréa Durão Neves, G. M. Barbosa
Background: Quality control of a homeopathic mother tincture begins with the analysis of the raw material. Once the product is obtained, some organoleptic characteristics and Physicochemical properties such as appearance, colour, odour, density, dry residue, alcohol content, and chemical marker are evaluated. In Brazil, mother tinctures from different suppliers may have high variability in terms of the specifications described in the homeopathic pharmacopoeia. Objective: The aim of the present study was to compare mother tinctures’ quality control from different pharmaceutical suppliers based on Brazilian Homeopathic Pharmacopoeia 3rd edition. Methods: Five mother tinctures were selected according to the high number of requests in the pharmacies, also its monographs are in the Brazilian Homeopathic Pharmacopoeia (FHB) 3rd edition. The report of analysis of the product was provided by three homeopathic pharmacies from the city of Rio de Janeiro. The information in the reports was evaluated and compared to its monograph. Results and discussion: In this study, it was found that the number of laboratories that provide homeopathic pharmaceutical ingredients is rather low. In addition, in some reports, a number of identification tests were not described properly when compared to the monograph. Besides that, some information diverges from the pharmacopoeia, for example, absence of dry residue testing, replacement of the part of the plant used to prepare the mother tincture, and results that do not meet pharmacopoeia specifications. As can be seen, the quality and effectiveness of homeopathic medicines prepared from these tinctures may be compromised. Conclusion: In order to guarantee consumer protection and the quality and effectiveness of medicines, governments and regulatory agencies should require a greater commitment from suppliers in the production of homeopathic inputs.
{"title":"Comparative analysis for quality control of mother tinctures in Brazilian reports","authors":"Vânia Emerich Bucco Campos, HA Pinheiro, Andréa Durão Neves, G. M. Barbosa","doi":"10.51910/ijhdr.v21i1.1167","DOIUrl":"https://doi.org/10.51910/ijhdr.v21i1.1167","url":null,"abstract":"Background: Quality control of a homeopathic mother tincture begins with the analysis of the raw material. Once the product is obtained, some organoleptic characteristics and Physicochemical properties such as appearance, colour, odour, density, dry residue, alcohol content, and chemical marker are evaluated. In Brazil, mother tinctures from different suppliers may have high variability in terms of the specifications described in the homeopathic pharmacopoeia. Objective: The aim of the present study was to compare mother tinctures’ quality control from different pharmaceutical suppliers based on Brazilian Homeopathic Pharmacopoeia 3rd edition. Methods: Five mother tinctures were selected according to the high number of requests in the pharmacies, also its monographs are in the Brazilian Homeopathic Pharmacopoeia (FHB) 3rd edition. The report of analysis of the product was provided by three homeopathic pharmacies from the city of Rio de Janeiro. The information in the reports was evaluated and compared to its monograph. Results and discussion: In this study, it was found that the number of laboratories that provide homeopathic pharmaceutical ingredients is rather low. In addition, in some reports, a number of identification tests were not described properly when compared to the monograph. Besides that, some information diverges from the pharmacopoeia, for example, absence of dry residue testing, replacement of the part of the plant used to prepare the mother tincture, and results that do not meet pharmacopoeia specifications. As can be seen, the quality and effectiveness of homeopathic medicines prepared from these tinctures may be compromised. Conclusion: In order to guarantee consumer protection and the quality and effectiveness of medicines, governments and regulatory agencies should require a greater commitment from suppliers in the production of homeopathic inputs.","PeriodicalId":106057,"journal":{"name":"International Journal of High Dilution Research - ISSN 1982-6206","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115952295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Semiology, Clinical Pathophysiology, Phytotherapy and Homeopathy were taught through active methodology by the Moodle platform (HL) also using apps for monitoring injuries through SAPB site, building rationality for the external topic use of homeopathic and herbal medicines. At the 7th Infirmary of General Hospital Santa Casa de Misericordia in Rio de Janeiro, the clinical medical team of the Benoit Mure Nucleus of Assistance Teaching and Research, made a medicinal plant garden with the agricultural/environmental educator, and community ethnical leaders. Undergraduate students from UNIFASE/FMP Academic League of Physiology and Pathophysiology planted Calendula Officinalis seedlings, destined to research in pharmacobotany and to be in touch with pharmacotechnical prepares. Aims: To follow-up the study since from seedling of Calendula Officinalis till to prepare of HUD. Methodology: To prepare medicinal garden: plant seedlings of Calendula offin accordance with good agricultural techniques. At first: Three seeds in ten pots, made in triplicate (N = 90), to obtain explants of quality analyzed whose evaluation was about plant development (explants percentual: weight, size, viability, morphology). To visit pharmacy-school to learn how to prepare matrix extracts and High Ultra-Diluted Solutions (HUD) of Calendula off 6DH. Results and Discussion: The stages of teaching semiology and practice in pharmacobotany, besides cultive plant have been completed. Viability was impaired because of lack of irrigation during 4 months (50%). Weight, size were minor than usual but with no statistical significance (p>0.05). Morphology was maintained. Unfortunately, the visit to pharmacy-school couldn’t be performed at this period. Conclusion: Through hybrid learning and face-to-face activities completely realized, students had qualitative perception of the relevance about morphology and quality of plant development, chemistry plant production, aiming for resolutive actions based upon pathophysiology of chronic diseases. Because of pandemic, it was described just a preliminary experience. After returning to normal activities the experiment will be repeated.
{"title":"Teaching and practice in Homeopathy via pharmacobotany and pathophysiology","authors":"Cláudio Hansel Martins, Patrícia Musmanno, Sandra Ávila Gaspar, Josiane Bentes, R. Ximenes, Denise Nagamatsu, Fábio Tavares, F. Bolognani, Marcia Braga Antunes Varricchio","doi":"10.51910/ijhdr.v21i1.1193","DOIUrl":"https://doi.org/10.51910/ijhdr.v21i1.1193","url":null,"abstract":"Background: Semiology, Clinical Pathophysiology, Phytotherapy and Homeopathy were taught through active methodology by the Moodle platform (HL) also using apps for monitoring injuries through SAPB site, building rationality for the external topic use of homeopathic and herbal medicines. At the 7th Infirmary of General Hospital Santa Casa de Misericordia in Rio de Janeiro, the clinical medical team of the Benoit Mure Nucleus of Assistance Teaching and Research, made a medicinal plant garden with the agricultural/environmental educator, and community ethnical leaders. Undergraduate students from UNIFASE/FMP Academic League of Physiology and Pathophysiology planted Calendula Officinalis seedlings, destined to research in pharmacobotany and to be in touch with pharmacotechnical prepares. Aims: To follow-up the study since from seedling of Calendula Officinalis till to prepare of HUD. Methodology: To prepare medicinal garden: plant seedlings of Calendula offin accordance with good agricultural techniques. At first: Three seeds in ten pots, made in triplicate (N = 90), to obtain explants of quality analyzed whose evaluation was about plant development (explants percentual: weight, size, viability, morphology). To visit pharmacy-school to learn how to prepare matrix extracts and High Ultra-Diluted Solutions (HUD) of Calendula off 6DH. Results and Discussion: The stages of teaching semiology and practice in pharmacobotany, besides cultive plant have been completed. Viability was impaired because of lack of irrigation during 4 months (50%). Weight, size were minor than usual but with no statistical significance (p>0.05). Morphology was maintained. Unfortunately, the visit to pharmacy-school couldn’t be performed at this period. Conclusion: Through hybrid learning and face-to-face activities completely realized, students had qualitative perception of the relevance about morphology and quality of plant development, chemistry plant production, aiming for resolutive actions based upon pathophysiology of chronic diseases. Because of pandemic, it was described just a preliminary experience. After returning to normal activities the experiment will be repeated.","PeriodicalId":106057,"journal":{"name":"International Journal of High Dilution Research - ISSN 1982-6206","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116713308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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