Clinical Neurophysiology最新文献_第9页

Ocular motor dysfunction in patients with multiple system atrophy and Parkinson’s disease 多系统萎缩和帕金森病患者的眼运动功能障碍

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2025-11-02 DOI: 10.1016/j.clinph.2025.2111413

Xia Ling , Xinyan Ma , Zhirong Wan , Yunchuang Sun , Fan Li , Luhua Wei , Kai Li , Jing Chen , Guiping Zhao , Ji-Soo Kim , Xu Yang , Zhaoxia Wang

Objective

Differentiating multiple system atrophy (MSA) from Parkinson’s disease (PD) remains challenging. This study aimed to investigate the utility of specific ocular motor features in distinguishing MSA from PD, as these dysfunctions may offer valuable diagnostic clues.

Methods

We used video-oculography to assess spontaneous nystagmus, saccadic intrusions or oscillations, gaze, saccades, head shaking, positional nystagmus, and vestibulo-ocular reflex (VOR) cancellation in 23 MSA patients and 49 PD patients.

Results

Spontaneous downbeat nystagmus, saccadic intrusions/oscillations, and perverted head shaking nystagmus (pHSN) didn’t differ between groups. Horizontal gaze-evoked nystagmus (GEN) occurred in MSA patients but not in PD (P = 0.009). MSA showed significantly more prolonged saccade latency (both horizontal and vertical) and vertical saccadic hypermetria than PD (all P < 0.05). Central positional nystagmus (CPN) was more common in MSA (P = 0.046). Impaired VOR cancellation was significantly higher in MSA than in PD (95.7 % vs. 32.7 %, P < 0.001).

Conclusion

MSA exhibits significantly more pronounced VOR cancellation deficits, horizontal GEN, CPN, saccadic hypermetria, and prolonged saccade latency than PD. These findings suggest a link to the more widespread neurodegeneration characteristic of MSA.

Significance

Impaired VOR cancellation, horizontal GEN, saccadic hypermetria, and CPN offer potential for distinguishing MSA from PD.

目的多系统萎缩（MSA）与帕金森病（PD）的鉴别仍然具有挑战性。本研究旨在探讨特异性眼运动特征在区分MSA和PD中的作用，因为这些功能障碍可能提供有价值的诊断线索。方法对23例MSA患者和49例PD患者的自发性眼球震、眼球侵犯或振荡、凝视、扫视、头摇、位置性眼球震和前庭眼反射（VOR）消除进行了观察。结果自发性下拍性眼球震颤、眼跳侵入/振荡、变态头摇型眼球震颤（pHSN）组间无明显差异。水平凝视诱发眼球震颤（GEN）发生在MSA患者中，而不发生在PD患者中（P = 0.009）。MSA显示的眼跳潜伏期（水平和垂直）和垂直眼跳高明显高于PD（均P <； 0.05）。中枢位置性眼球震颤（CPN）在MSA中更为常见（P = 0.046）。MSA中受损的VOR取消明显高于PD（95.7%比32.7%,P < 0.001）。结论msa比PD表现出更明显的VOR取消缺陷、水平GEN、CPN、跳眼高速和延长的跳眼潜伏期。这些发现表明与MSA更广泛的神经退行性变特征有关。意义：受损的VOR取消、水平GEN、跳高和CPN提供了区分MSA和PD的潜力。

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引用次数: 0

Spike density in children with self-limited focal epilepsies affects memory performance and slow wave-spindle coupling during sleep 自限性局灶性癫痫儿童的脑电波密度影响睡眠时的记忆表现和慢波-纺锤体耦合

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2025-11-01 DOI: 10.1016/j.clinph.2025.2111406

Elena C. Schmidt , Sarah Storz , Jelena Skorucak , Georgia Ramantani , Bigna K. Bölsterli , Sara Fattinger , Reto Huber

Objective

Precise coupling of slow waves and spindles during non-rapid eye movement (NREM) sleep is crucial for memory consolidation. Children with self-limited focal epilepsies (SelFE) show epileptic spike waves during NREM sleep and often have impaired sleep-related memory. We investigated for the first time how spikes affect slow wave–spindle coupling and its impact on overnight memory.

Methods

Fourteen SelFE patients (mean age: 8.7 years) underwent overnight high-density EEG (128 channels) and completed a word-pair memory task before and after sleep. Spikes, spindles, and slow waves were automatically detected. Coupling precision was defined as the ratio of spindles during the ascending versus descending phase of the slow wave. Cluster-corrected topographical correlations examined relationships between spike density, coupling precision, and memory outcomes.

Results

Higher spike density was associated with poorer memory performance in a left centro-parietal region. Better memory was linked to greater coupling precision during the ascending phase in a left centro-frontal area. Increased spike density also correlated with reduced coupling precision in a central region.

Conclusion

Spikes may disrupt thalamocortical activity, impairing slow wave–spindle coupling and memory consolidation.

Significance

These findings suggest a mechanistic link between epileptic sleep activity and cognitive deficits in SelFE.

目的非快速眼动（NREM）睡眠中慢波和纺锤波的精确耦合对记忆巩固至关重要。患有自限性局灶性癫痫的儿童在非快速眼动睡眠期间表现出癫痫性尖峰波，并且通常有睡眠相关记忆受损。我们首次研究了尖波如何影响慢波-主轴耦合及其对夜间记忆的影响。方法14例患者（平均年龄8.7岁）进行夜间高密度脑电图（128通道），并在睡眠前后完成单词对记忆任务。尖峰波、纺锤波和慢波被自动检测到。耦合精度定义为慢波上升与下降阶段主轴的比值。簇校正的地形相关性检验了尖峰密度、耦合精度和记忆结果之间的关系。结果高尖峰密度与左中顶叶区较差的记忆表现相关。在上升阶段，更好的记忆力与更高的耦合精度在左中央额叶区有关。增加的尖峰密度也与中心区域的耦合精度降低相关。结论峰电位可破坏丘脑皮层活动，损害慢波-纺锤体耦合和记忆巩固。这些发现表明癫痫性睡眠活动与自我认知缺陷之间存在机制联系。

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引用次数: 0

EEG dynamics under anesthetics-induced loss and return of responsiveness with A constant rate infusion 恒速输注麻醉引起的反应性丧失和恢复的脑电图动力学

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2025-11-01 DOI: 10.1016/j.clinph.2025.2111411

Xiaoge Liu , Yu Chang , Xin Wang , Shitong Li , Zhenhu Liang , Jun Zhang

Objective

This study aims to characterize the electroencephalographic dynamics during the transition to and from loss of responsiveness (LOR) induced by three anesthetics.

Methods

High-density EEG was recorded in 60 patients randomly receiving propofol, dexmedetomidine, or ketamine with a constant rate infusion. Spectral power, phase-amplitude coupling (PAC), coherence and directed phase transfer entropy during awake, LOR and recovery (ROR) states were analyzed to evaluate neural dynamics associated with altered conscious states.

Results

Propofol increased global alpha power and low-frequency slow oscillations (SO) without “alpha anteriorization” during LOR. Dexmedetomidine increased SO but decreased alpha power. Ketamine reduced alpha power and increased occipital theta and gamma power. Further, three anesthetic displayed distinct PAC patterns and induced region-specific and frequency-specific long-range functional connectivity patterns. Directed connectivity analysis indicated propofol and ketamine rather than dexmedetomidine inhibited feedback connectivity during LOR.

Conclusions

Three anesthetics induced differential spectral power, PAC, and network connectivity during the transition to and from LOR when infused with a constant rate, suggesting that EEG dynamics vary not only among anesthetics, but also among regimens of their administration.

Significance

Anesthetic-specific neural signatures and administration-dependent EEG patterns, advance precision anesthesia monitoring and deepen understanding of conscious state transitions under distinct pharmacologic modulations.

目的研究三种麻醉药致反应性丧失前后的脑电图动态特征。方法对60例随机接受异丙酚、右美托咪定或氯胺酮等速输注的患者进行高密度脑电图记录。分析了清醒、LOR和恢复（ROR）状态下的谱功率、相幅耦合（PAC）、相干性和定向相转移熵，以评估与意识状态改变相关的神经动力学。结果异丙酚增加了LOR期间的总α功率和低频慢振荡（SO），但没有“α前化”。右美托咪定增加了SO，但降低了α功率。氯胺酮降低了α能量，增加了枕部θ和γ能量。此外，三种麻醉剂显示出不同的PAC模式，并诱导区域特异性和频率特异性的远程功能连接模式。定向连通性分析表明异丙酚和氯胺酮而不是右美托咪定抑制LOR期间的反馈连通性。结论三种麻醉药在注入恒定剂量时，会引起脑电信号功率、PAC和网络连通性的差异，表明脑电图动态不仅在麻醉药之间存在差异，而且在给药方案之间也存在差异。麻醉特异性神经特征和给药依赖性脑电图模式，促进了麻醉的精确监测，加深了对不同药物调节下意识状态转变的理解。

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引用次数: 0

A brake on the blink: EEG antecedents of movement suppression and urge to move 眨眼的刹车：运动抑制和运动冲动的脑电图前因。

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2025-11-01 DOI: 10.1016/j.clinph.2025.2110997

Antonio Ivano Triggiani , Lucrezia Liuzzi , Kaya Scheman , Mark Hallett

Objective

To compare brain activity before voluntary movement and before the same movement when it was released from suppression. This study examined the Bereitschaftspotential (BP) and beta band event-related desynchronization (bERD) during active blink suppression, contrasting these with voluntary blinking, where these EEG correlates of motor preparation are well-established.

Methods

Fifteen healthy adults performed voluntary blink and blink suppression-release tasks with EEG recording. Time-locked analyses focused on BP and bERD for each condition.

Results

Voluntary blinks showed a robust negative BP, which was markedly attenuated after a period of active suppression. Overall bERD did not significantly differ, but low-frequency bERD mirrored BP activity, while high-frequency bERD showed typical desynchronization.

Conclusion

The dissociation between BP and bERD suggests distinct neurophysiological mechanisms related to the voluntary control and urge to move in fundamental actions like blinks, involving active suppression of typical motor preparation rather than just absent activation. This insight into the neural control of suppressing even basic motor acts may be relevant to understanding conditions characterized by difficulties in action suppression, such as tic disorders.

Significance

This study offers novel insights into the neural correlates of suppressing seemingly unavoidable physiological responses, enhancing our understanding of inhibitory control and potentially impacting the study of conditions with action suppression deficits.

目的：比较自主运动前与自主运动解除抑制前的脑活动。本研究检查了主动眨眼抑制期间的静止电位（BP）和β频带事件相关失同步（bERD），并将其与自愿眨眼进行对比，其中这些运动准备的脑电图相关性已经得到证实。方法：15名健康成人进行自主眨眼和眨眼抑制释放任务，并进行脑电图记录。时间锁定分析侧重于每种情况下的BP和bERD。结果：自主眨眼表现出强烈的负BP，经过一段时间的主动抑制后明显减弱。总体bERD差异不显著，但低频bERD反映了BP活动，而高频bERD表现出典型的不同步。结论：BP和bERD之间的分离表明，在眨眼等基本动作中，与自主控制和运动冲动相关的不同神经生理机制涉及典型运动准备的主动抑制，而不仅仅是缺失激活。这种对抑制基本运动行为的神经控制的洞察可能与理解以动作抑制困难为特征的条件有关，例如抽动障碍。意义：本研究为抑制看似不可避免的生理反应的神经相关性提供了新的见解，增强了我们对抑制控制的理解，并可能影响动作抑制缺陷条件的研究。

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引用次数: 0

The urge to blink 想眨眼的冲动。

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2025-11-01 DOI: 10.1016/j.clinph.2025.2110998

Josep Valls-Solé

引用次数: 0

Respiratory muscle activity and fatigue response during respiratory endurance testing in patients with spinal muscular atrophy 脊髓性肌萎缩症患者呼吸耐力试验中的呼吸肌活动和疲劳反应。

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2025-10-30 DOI: 10.1016/j.clinph.2025.2111408

Kim Kant-Smits , Lisa Pomp , Laura E. Habets , Erik H.J. Hulzebos , Jeroen A.L. Jeneson , Fay-Lynn Asselman , Janke F. de Groot , C. Kors van der Ent , Ruben P.A. van Eijk , W. Ludo van der Pol , Bart Bartels

Objective

To explore respiratory muscle activity and fatigue response during a respiratory endurance test (RET) in patients with spinal muscular atrophy (SMA).

Methods

Fifty-five participants with SMA types 2 and 3 performed a respiratory endurance test (RET) at 20 %-70 % of their maximum inspiratory mouth pressure (PImax). We recorded surface electromyography (sEMG) of the diaphragm, intercostal, and scalene muscles and evaluated muscle activity at onset and during the test. Respiratory muscle fatigability (RMF) was defined as the inability to complete 60 consecutive breaths during the RET.

Results

The diaphragm showed a significantly lower variance in activity at onset of the test compared to the intercostal and scalene muscles (p = 0.002). Participants with RMF showed fatigue of the diaphragm, indicated by a significant decrease in root mean square amplitude (p = 0.012) and median frequency (p < 0.001), compared to those without RMF.

Conclusion

The relative activity of the diaphragm at onset of a RET remained stable at higher intensity levels, while the activity of the intercostal and scalene muscles became more variable. The diaphragm showed significant electrophysiological signs of fatigue, while accessory inspiratory muscles showed no clear electrophysiological fatigue signs.

Significance

The results of this study provide more insight into respiratory muscle function and fatigability in patients with SMA.

目的：探讨脊髓性肌萎缩症（SMA）患者呼吸耐力试验（RET）时呼吸肌活动和疲劳反应。方法：55名2型和3型SMA患者在其最大吸气口压（PImax）的20% - 70%进行呼吸耐力试验（RET）。我们记录了膈肌、肋间肌和斜角肌的表面肌电图（sEMG），并评估了开始时和测试期间的肌肉活动。呼吸肌疲劳（RMF）被定义为在测试期间无法完成60次连续呼吸。结果：与肋间肌和斜角肌相比，横膈膜在测试开始时的活动差异显著降低（p = 0.002）。RMF的参与者表现出膈肌疲劳，这是由均方根振幅（p = 0.012）和中位数频率(p)的显著下降所表明的。结论：RET开始时膈肌的相对活动在高强度水平下保持稳定，而肋间肌和斜角肌的活动变得更加可变。膈肌有明显的疲劳电生理征象，而副吸气肌无明显的疲劳电生理征象。意义：本研究结果对SMA患者的呼吸肌功能和疲劳有了更深入的了解。

{"title":"Respiratory muscle activity and fatigue response during respiratory endurance testing in patients with spinal muscular atrophy","authors":"Kim Kant-Smits , Lisa Pomp , Laura E. Habets , Erik H.J. Hulzebos , Jeroen A.L. Jeneson , Fay-Lynn Asselman , Janke F. de Groot , C. Kors van der Ent , Ruben P.A. van Eijk , W. Ludo van der Pol , Bart Bartels","doi":"10.1016/j.clinph.2025.2111408","DOIUrl":"10.1016/j.clinph.2025.2111408","url":null,"abstract":"<div><h3>Objective</h3><div>To explore respiratory muscle activity and fatigue response during a respiratory endurance test (RET) in patients with spinal muscular atrophy (SMA).</div></div><div><h3>Methods</h3><div>Fifty-five participants with SMA types 2 and 3 performed a respiratory endurance test (RET) at 20 %-70 % of their maximum inspiratory mouth pressure (PImax). We recorded surface electromyography (sEMG) of the diaphragm, intercostal, and scalene muscles and evaluated muscle activity at onset and during the test. Respiratory muscle fatigability (RMF) was defined as the inability to complete 60 consecutive breaths during the RET.</div></div><div><h3>Results</h3><div>The diaphragm showed a significantly lower variance in activity at onset of the test compared to the intercostal and scalene muscles (<em>p</em> = 0.002). Participants with RMF showed fatigue of the diaphragm, indicated by a significant decrease in root mean square amplitude (<em>p</em> = 0.012) and median frequency (<em>p</em> < 0.001), compared to those without RMF.</div></div><div><h3>Conclusion</h3><div>The relative activity of the diaphragm at onset of a RET remained stable at higher intensity levels, while the activity of the intercostal and scalene muscles became more variable. The diaphragm showed significant electrophysiological signs of fatigue, while accessory inspiratory muscles showed no clear electrophysiological fatigue signs.</div></div><div><h3>Significance</h3><div>The results of this study provide more insight into respiratory muscle function and fatigability in patients with SMA.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"181 ","pages":"Article 2111408"},"PeriodicalIF":3.6,"publicationDate":"2025-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145480568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Resting-state functional connectivity guides motor hotspot localization 静息状态功能连接引导运动热点定位

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2025-10-28 DOI: 10.1016/j.clinph.2025.2111410

Antonio Luigi Bisogno , Ilaria Mazzonetto , Valentina D’Onofrio , Ester Fusaro , Renzo Manara , Simone Sarasso , Silvia Casarotto , Mario Rosanova , Marcello Massimini , Camillo Porcaro , Lorenzo Pini , Maurizio Corbetta

引用次数: 0

Magnetoneurography as a novel functional imaging technique for cervical myelopathy 磁神经成像作为一种新型的功能成像技术用于颈椎病。

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2025-10-28 DOI: 10.1016/j.clinph.2025.2111409

Shigenori Kawabata , Yuko Hoshino , Yoshiaki Adachi , Taishi Watanabe , Kensuke Sekihara , Toru Sasaki , Jun Hashimoto , Satoshi Sumiya , Atsushi Okawa , Toshitaka Yoshii

Objective

To evaluate the efficacy of magnetoneurography (MNG) in examination of neurological conditions in degenerative cervical myelopathy.

Methods

The left median and ulnar nerves were electrically stimulated in 25 healthy participants and 21 patients. The evoked magnetic fields were recorded using a 132-channel superconducting quantum interference device biomagnetometer system and spatiotemporal changes in reconstructed action currents were evaluated. The correspondence of the MNG and MRI diagnoses with neurological findings was evaluated by two board-certified orthopaedists.

Results

Evoked magnetic fields were recorded in all participants. In 16 patients, there was no inconsistency between the MRI and MNG findings. In the remaining five cases, the lesions diagnosed by MNG were at a lower level than those diagnosed by MRI.

Conclusions

MNG was able to visualise the spatiotemporal course of neural currents, which is difficult to record in conventional electrophysiological examinations. Because the lesional level of the spinal cord in MRI is not always consistent with the neurological findings, MNG might be able to detect the electrophysiological change in the spinal cord at a level below the compression site.

Significance

MNG has the potential to be a comprehensible imaging technique and to provide novel neurological findings.

目的：评价磁神经造影（MNG）在退行性颈椎病神经系统疾病检查中的应用价值。方法：电刺激25例正常人和21例患者的左正中神经和尺神经。利用132通道超导量子干涉装置生物磁强计系统记录了诱发磁场，并评估了重建作用电流的时空变化。MNG和MRI诊断与神经学发现的一致性由两名认证的骨科医生评估。结果：所有受试者均记录了诱发磁场。在16例患者中，MRI和MNG的结果没有不一致。在其余5例中，MNG诊断的病变低于MRI诊断的病变。结论：MNG能够直观显示神经电流的时空变化，这是常规电生理检查难以记录的。由于MRI显示的脊髓病变水平与神经学表现并不总是一致，因此MNG可能能够检测受压部位以下水平脊髓的电生理变化。意义：MNG有潜力成为一种可理解的成像技术，并提供新的神经学发现。

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引用次数: 0

Delta/gamma band network abnormalities and enhanced phase-amplitude coupling in anti-leucine-rich glioma-inactivated 1 encephalitis 抗富亮氨酸胶质瘤失活1脑炎的δ / γ波段网络异常和相幅耦合增强。

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2025-10-28 DOI: 10.1016/j.clinph.2025.2111401

Ping Jiang , Lei Wang , Yingfan Wang , Minghao Li, Dingfeng Sun, Jing Lu, Ailiang Miao, Xiaoshan Wang

Objective

To characterize functional network abnormalities in patients with anti-leucine-rich glioma-inactivated 1 (LGI1) encephalitis using electroencephalogram (EEG) recordings.

Methods

Eleven patients and eleven controls calculated relative power spectral density (PSD) and underwent functional connectivity analysis using corrected amplitude envelope correlation (AEC-c). Amplitude envelopes were extracted across five frequency bands, and network topology was analyzed by node strength. Phase-amplitude coupling (PAC) assessed cross-frequency interactions.

Results

Patients showed significantly increased delta band power and decreased alpha band power (both p < 0.001). AEC-c analysis revealed reduced functional connectivity in delta (p = 0.0396) and gamma bands (p = 0.001), with delta band connectivity weakened between occipital and frontotemporal regions and gamma connectivity broadly diminished. No significant differences in node strength were observed. PAC analysis showed enhanced coupling in the frontal, parietal, temporal, and occipital regions (all p < 0.05).

Conclusions

Patients with anti-LGI1 encephalitis show increased delta and reduced alpha power, with decreased delta and gamma connectivity, while global network connectivity may remain partially stable, potentially supported by delta-gamma coupling.

Significance

This study highlights altered power, network abnormalities, and enhanced coupling in anti-LGI1 encephalitis, offering new insights into its pathophysiology.

目的：利用脑电图（EEG）记录分析抗富亮氨酸胶质瘤失活1 （LGI1）脑炎患者的功能网络异常。方法：11例患者和11例对照组计算相对功率谱密度（PSD），并采用校正振幅包络相关（AEC-c）进行功能连通性分析。在5个频带中提取幅值包络，并根据节点强度分析网络拓扑结构。相位振幅耦合（PAC）评估交叉频率相互作用。结论：抗lgi1脑炎患者表现为δ波功率增加和α波功率降低，δ波和γ波连通性下降，而全球网络连通性可能保持部分稳定，可能由δ - γ耦合支持。意义：本研究强调了抗lgi1脑炎的功能改变、网络异常和偶联增强，为其病理生理学提供了新的见解。

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引用次数: 0

The effect of perceived auditory feedback on speech Brain-Computer Interface decoding performance 听觉感知反馈对语音脑机接口解码性能的影响。

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2025-10-26 DOI: 10.1016/j.clinph.2025.2111403

A. Schippers , J. Berezutskaya , M.J. Vansteensel , Z.V. Freudenburg , N.E. Crone , N.F. Ramsey

Objective

Brain-Computer Interfaces (BCI) provide alternative means of communication for individuals with severe motor impairment. Implantable speech BCIs have shown great potential, particularly in individuals who could still produce some speech-related movements and/or sounds. As perception of auditory feedback is important for correct speech sound production in able-bodied people, it is conceivable that a complete absence of such feedback in individuals who lost all ability to produce audible speech affects BCI performance. The current study therefore set out to investigate to what extent perception of auditory feedback of self-produced speech contributes to speech decoding performance.

Methods

In three able-bodied participants, patterns of 65–95 Hz power over sensorimotor cortex were compared between normal speech and speech in which auditory feedback was masked by noise. In addition, decoding accuracy was compared between feedback situations.

Results & Conclusions

We found subtle differences in brain activity patterns associated with speech production between situations in which participants could versus could not perceive their produced speech. Importantly, absence of such auditory feedback led to lower speech decoding performance in all participants.

Significance

These results underline the need to validate speech BCI efficacy with fully paralyzed individuals, as perceived feedback can influence the attainable speech decoding accuracy.

目的：脑机接口（BCI）为重度运动障碍患者提供了另一种交流方式。植入式语音脑机接口已经显示出巨大的潜力，特别是对于那些仍然可以产生一些与语言相关的动作和/或声音的个体。对于健全的人来说，听觉反馈的感知对于正确的语音产生非常重要，因此可以想象，在完全丧失发声能力的个体中，完全缺乏这种反馈会影响脑机接口的表现。因此，本研究旨在探讨自我产生语音的听觉反馈感知对语音解码性能的影响程度。方法：在3名健全的被试中，比较了正常言语和听觉反馈被噪音掩盖的言语在感觉运动皮层上65-95 Hz的功率模式。此外，还比较了不同反馈情况下的译码精度。结果与结论：我们发现，在参与者能够感知和无法感知他们所产生的语言的情况下，与语言产生相关的大脑活动模式存在细微差异。重要的是，缺乏这种听觉反馈导致所有参与者的语音解码性能下降。意义：这些结果强调了需要在完全瘫痪的个体中验证语音脑机接口的有效性，因为感知反馈会影响可实现的语音解码精度。

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引用次数: 0