Pub Date : 2025-11-01DOI: 10.1016/j.clinph.2025.2111406
Elena C. Schmidt , Sarah Storz , Jelena Skorucak , Georgia Ramantani , Bigna K. Bölsterli , Sara Fattinger , Reto Huber
Objective
Precise coupling of slow waves and spindles during non-rapid eye movement (NREM) sleep is crucial for memory consolidation. Children with self-limited focal epilepsies (SelFE) show epileptic spike waves during NREM sleep and often have impaired sleep-related memory. We investigated for the first time how spikes affect slow wave–spindle coupling and its impact on overnight memory.
Methods
Fourteen SelFE patients (mean age: 8.7 years) underwent overnight high-density EEG (128 channels) and completed a word-pair memory task before and after sleep. Spikes, spindles, and slow waves were automatically detected. Coupling precision was defined as the ratio of spindles during the ascending versus descending phase of the slow wave. Cluster-corrected topographical correlations examined relationships between spike density, coupling precision, and memory outcomes.
Results
Higher spike density was associated with poorer memory performance in a left centro-parietal region. Better memory was linked to greater coupling precision during the ascending phase in a left centro-frontal area. Increased spike density also correlated with reduced coupling precision in a central region.
Conclusion
Spikes may disrupt thalamocortical activity, impairing slow wave–spindle coupling and memory consolidation.
Significance
These findings suggest a mechanistic link between epileptic sleep activity and cognitive deficits in SelFE.
{"title":"Spike density in children with self-limited focal epilepsies affects memory performance and slow wave-spindle coupling during sleep","authors":"Elena C. Schmidt , Sarah Storz , Jelena Skorucak , Georgia Ramantani , Bigna K. Bölsterli , Sara Fattinger , Reto Huber","doi":"10.1016/j.clinph.2025.2111406","DOIUrl":"10.1016/j.clinph.2025.2111406","url":null,"abstract":"<div><h3>Objective</h3><div>Precise coupling of slow waves and spindles during non-rapid eye movement (NREM) sleep is crucial for memory consolidation. Children with self-limited focal epilepsies (SelFE) show epileptic spike waves during NREM sleep and often have impaired sleep-related memory. We investigated for the first time how spikes affect slow wave–spindle coupling and its impact on overnight memory.</div></div><div><h3>Methods</h3><div>Fourteen SelFE patients (mean age: 8.7 years) underwent overnight high-density EEG (128 channels) and completed a word-pair memory task before and after sleep. Spikes, spindles, and slow waves were automatically detected. Coupling precision was defined as the ratio of spindles during the ascending versus descending phase of the slow wave. Cluster-corrected topographical correlations examined relationships between spike density, coupling precision, and memory outcomes.</div></div><div><h3>Results</h3><div>Higher spike density was associated with poorer memory performance in a left centro-parietal region. Better memory was linked to greater coupling precision during the ascending phase in a left centro-frontal area. Increased spike density also correlated with reduced coupling precision in a central region.</div></div><div><h3>Conclusion</h3><div>Spikes may disrupt thalamocortical activity, impairing slow wave–spindle coupling and memory consolidation.</div></div><div><h3>Significance</h3><div>These findings suggest a mechanistic link between epileptic sleep activity and cognitive deficits in SelFE.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"181 ","pages":"Article 2111406"},"PeriodicalIF":3.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145465095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.clinph.2025.2111411
Xiaoge Liu , Yu Chang , Xin Wang , Shitong Li , Zhenhu Liang , Jun Zhang
Objective
This study aims to characterize the electroencephalographic dynamics during the transition to and from loss of responsiveness (LOR) induced by three anesthetics.
Methods
High-density EEG was recorded in 60 patients randomly receiving propofol, dexmedetomidine, or ketamine with a constant rate infusion. Spectral power, phase-amplitude coupling (PAC), coherence and directed phase transfer entropy during awake, LOR and recovery (ROR) states were analyzed to evaluate neural dynamics associated with altered conscious states.
Results
Propofol increased global alpha power and low-frequency slow oscillations (SO) without “alpha anteriorization” during LOR. Dexmedetomidine increased SO but decreased alpha power. Ketamine reduced alpha power and increased occipital theta and gamma power. Further, three anesthetic displayed distinct PAC patterns and induced region-specific and frequency-specific long-range functional connectivity patterns. Directed connectivity analysis indicated propofol and ketamine rather than dexmedetomidine inhibited feedback connectivity during LOR.
Conclusions
Three anesthetics induced differential spectral power, PAC, and network connectivity during the transition to and from LOR when infused with a constant rate, suggesting that EEG dynamics vary not only among anesthetics, but also among regimens of their administration.
Significance
Anesthetic-specific neural signatures and administration-dependent EEG patterns, advance precision anesthesia monitoring and deepen understanding of conscious state transitions under distinct pharmacologic modulations.
{"title":"EEG dynamics under anesthetics-induced loss and return of responsiveness with A constant rate infusion","authors":"Xiaoge Liu , Yu Chang , Xin Wang , Shitong Li , Zhenhu Liang , Jun Zhang","doi":"10.1016/j.clinph.2025.2111411","DOIUrl":"10.1016/j.clinph.2025.2111411","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to characterize the electroencephalographic dynamics during the transition to and from loss of responsiveness (LOR) induced by three anesthetics.</div></div><div><h3>Methods</h3><div>High-density EEG was recorded in 60 patients randomly receiving propofol, dexmedetomidine, or ketamine with a constant rate infusion. Spectral power, phase-amplitude coupling (PAC), coherence and directed phase transfer entropy during awake, LOR and recovery (ROR) states were analyzed to evaluate neural dynamics associated with altered conscious states.</div></div><div><h3>Results</h3><div>Propofol increased global alpha power and low-frequency slow oscillations (SO) without “alpha anteriorization” during LOR. Dexmedetomidine increased SO but decreased alpha power. Ketamine reduced alpha power and increased occipital theta and gamma power. Further, three anesthetic displayed distinct PAC patterns and induced region-specific and frequency-specific long-range functional connectivity patterns. Directed connectivity analysis indicated propofol and ketamine rather than dexmedetomidine inhibited feedback connectivity during LOR.</div></div><div><h3>Conclusions</h3><div>Three anesthetics induced differential spectral power, PAC, and network connectivity during the transition to and from LOR when infused with a constant rate, suggesting that EEG dynamics vary not only among anesthetics, but also among regimens of their administration.</div></div><div><h3>Significance</h3><div>Anesthetic-specific neural signatures and administration-dependent EEG patterns, advance precision anesthesia monitoring and deepen understanding of conscious state transitions under distinct pharmacologic modulations.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"181 ","pages":"Article 2111411"},"PeriodicalIF":3.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145435575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.clinph.2025.2110997
Antonio Ivano Triggiani , Lucrezia Liuzzi , Kaya Scheman , Mark Hallett
Objective
To compare brain activity before voluntary movement and before the same movement when it was released from suppression. This study examined the Bereitschaftspotential (BP) and beta band event-related desynchronization (bERD) during active blink suppression, contrasting these with voluntary blinking, where these EEG correlates of motor preparation are well-established.
Methods
Fifteen healthy adults performed voluntary blink and blink suppression-release tasks with EEG recording. Time-locked analyses focused on BP and bERD for each condition.
Results
Voluntary blinks showed a robust negative BP, which was markedly attenuated after a period of active suppression. Overall bERD did not significantly differ, but low-frequency bERD mirrored BP activity, while high-frequency bERD showed typical desynchronization.
Conclusion
The dissociation between BP and bERD suggests distinct neurophysiological mechanisms related to the voluntary control and urge to move in fundamental actions like blinks, involving active suppression of typical motor preparation rather than just absent activation. This insight into the neural control of suppressing even basic motor acts may be relevant to understanding conditions characterized by difficulties in action suppression, such as tic disorders.
Significance
This study offers novel insights into the neural correlates of suppressing seemingly unavoidable physiological responses, enhancing our understanding of inhibitory control and potentially impacting the study of conditions with action suppression deficits.
{"title":"A brake on the blink: EEG antecedents of movement suppression and urge to move","authors":"Antonio Ivano Triggiani , Lucrezia Liuzzi , Kaya Scheman , Mark Hallett","doi":"10.1016/j.clinph.2025.2110997","DOIUrl":"10.1016/j.clinph.2025.2110997","url":null,"abstract":"<div><h3>Objective</h3><div>To compare brain activity before voluntary movement and before the same movement when it was released from suppression. This study examined the Bereitschaftspotential (BP) and beta band event-related desynchronization (bERD) during active blink suppression, contrasting these with voluntary blinking, where these EEG correlates of motor preparation are well-established.</div></div><div><h3>Methods</h3><div>Fifteen healthy adults performed voluntary blink and blink suppression-release tasks with EEG recording. Time-locked analyses focused on BP and bERD for each condition.</div></div><div><h3>Results</h3><div>Voluntary blinks showed a robust negative BP, which was markedly attenuated after a period of active suppression. Overall bERD did not significantly differ, but low-frequency bERD mirrored BP activity, while high-frequency bERD showed typical desynchronization.</div></div><div><h3>Conclusion</h3><div>The dissociation between BP and bERD suggests distinct neurophysiological mechanisms related to the voluntary control and urge to move in fundamental actions like blinks, involving active suppression of typical motor preparation rather than just absent activation. This insight into the neural control of suppressing even basic motor acts may be relevant to understanding conditions characterized by difficulties in action suppression, such as tic disorders.</div></div><div><h3>Significance</h3><div>This study offers novel insights into the neural correlates of suppressing seemingly unavoidable physiological responses, enhancing our understanding of inhibitory control and potentially impacting the study of conditions with action suppression deficits.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"179 ","pages":"Article 2110997"},"PeriodicalIF":3.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-30DOI: 10.1016/j.clinph.2025.2111408
Kim Kant-Smits , Lisa Pomp , Laura E. Habets , Erik H.J. Hulzebos , Jeroen A.L. Jeneson , Fay-Lynn Asselman , Janke F. de Groot , C. Kors van der Ent , Ruben P.A. van Eijk , W. Ludo van der Pol , Bart Bartels
Objective
To explore respiratory muscle activity and fatigue response during a respiratory endurance test (RET) in patients with spinal muscular atrophy (SMA).
Methods
Fifty-five participants with SMA types 2 and 3 performed a respiratory endurance test (RET) at 20 %-70 % of their maximum inspiratory mouth pressure (PImax). We recorded surface electromyography (sEMG) of the diaphragm, intercostal, and scalene muscles and evaluated muscle activity at onset and during the test. Respiratory muscle fatigability (RMF) was defined as the inability to complete 60 consecutive breaths during the RET.
Results
The diaphragm showed a significantly lower variance in activity at onset of the test compared to the intercostal and scalene muscles (p = 0.002). Participants with RMF showed fatigue of the diaphragm, indicated by a significant decrease in root mean square amplitude (p = 0.012) and median frequency (p < 0.001), compared to those without RMF.
Conclusion
The relative activity of the diaphragm at onset of a RET remained stable at higher intensity levels, while the activity of the intercostal and scalene muscles became more variable. The diaphragm showed significant electrophysiological signs of fatigue, while accessory inspiratory muscles showed no clear electrophysiological fatigue signs.
Significance
The results of this study provide more insight into respiratory muscle function and fatigability in patients with SMA.
{"title":"Respiratory muscle activity and fatigue response during respiratory endurance testing in patients with spinal muscular atrophy","authors":"Kim Kant-Smits , Lisa Pomp , Laura E. Habets , Erik H.J. Hulzebos , Jeroen A.L. Jeneson , Fay-Lynn Asselman , Janke F. de Groot , C. Kors van der Ent , Ruben P.A. van Eijk , W. Ludo van der Pol , Bart Bartels","doi":"10.1016/j.clinph.2025.2111408","DOIUrl":"10.1016/j.clinph.2025.2111408","url":null,"abstract":"<div><h3>Objective</h3><div>To explore respiratory muscle activity and fatigue response during a respiratory endurance test (RET) in patients with spinal muscular atrophy (SMA).</div></div><div><h3>Methods</h3><div>Fifty-five participants with SMA types 2 and 3 performed a respiratory endurance test (RET) at 20 %-70 % of their maximum inspiratory mouth pressure (PImax). We recorded surface electromyography (sEMG) of the diaphragm, intercostal, and scalene muscles and evaluated muscle activity at onset and during the test. Respiratory muscle fatigability (RMF) was defined as the inability to complete 60 consecutive breaths during the RET.</div></div><div><h3>Results</h3><div>The diaphragm showed a significantly lower variance in activity at onset of the test compared to the intercostal and scalene muscles (<em>p</em> = 0.002). Participants with RMF showed fatigue of the diaphragm, indicated by a significant decrease in root mean square amplitude (<em>p</em> = 0.012) and median frequency (<em>p</em> < 0.001), compared to those without RMF.</div></div><div><h3>Conclusion</h3><div>The relative activity of the diaphragm at onset of a RET remained stable at higher intensity levels, while the activity of the intercostal and scalene muscles became more variable. The diaphragm showed significant electrophysiological signs of fatigue, while accessory inspiratory muscles showed no clear electrophysiological fatigue signs.</div></div><div><h3>Significance</h3><div>The results of this study provide more insight into respiratory muscle function and fatigability in patients with SMA.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"181 ","pages":"Article 2111408"},"PeriodicalIF":3.6,"publicationDate":"2025-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145480568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
To evaluate the efficacy of magnetoneurography (MNG) in examination of neurological conditions in degenerative cervical myelopathy.
Methods
The left median and ulnar nerves were electrically stimulated in 25 healthy participants and 21 patients. The evoked magnetic fields were recorded using a 132-channel superconducting quantum interference device biomagnetometer system and spatiotemporal changes in reconstructed action currents were evaluated. The correspondence of the MNG and MRI diagnoses with neurological findings was evaluated by two board-certified orthopaedists.
Results
Evoked magnetic fields were recorded in all participants. In 16 patients, there was no inconsistency between the MRI and MNG findings. In the remaining five cases, the lesions diagnosed by MNG were at a lower level than those diagnosed by MRI.
Conclusions
MNG was able to visualise the spatiotemporal course of neural currents, which is difficult to record in conventional electrophysiological examinations. Because the lesional level of the spinal cord in MRI is not always consistent with the neurological findings, MNG might be able to detect the electrophysiological change in the spinal cord at a level below the compression site.
Significance
MNG has the potential to be a comprehensible imaging technique and to provide novel neurological findings.
{"title":"Magnetoneurography as a novel functional imaging technique for cervical myelopathy","authors":"Shigenori Kawabata , Yuko Hoshino , Yoshiaki Adachi , Taishi Watanabe , Kensuke Sekihara , Toru Sasaki , Jun Hashimoto , Satoshi Sumiya , Atsushi Okawa , Toshitaka Yoshii","doi":"10.1016/j.clinph.2025.2111409","DOIUrl":"10.1016/j.clinph.2025.2111409","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the efficacy of magnetoneurography (MNG) in examination of neurological conditions in degenerative cervical myelopathy.</div></div><div><h3>Methods</h3><div>The left median and ulnar nerves were electrically stimulated in 25 healthy participants and 21 patients. The evoked magnetic fields were recorded using a 132-channel superconducting quantum interference device biomagnetometer system and spatiotemporal changes in reconstructed action currents were evaluated. The correspondence of the MNG and MRI diagnoses with neurological findings was evaluated by two board-certified orthopaedists.</div></div><div><h3>Results</h3><div>Evoked magnetic fields were recorded in all participants. In 16 patients, there was no inconsistency between the MRI and MNG findings. In the remaining five cases, the lesions diagnosed by MNG were at a lower level than those diagnosed by MRI.</div></div><div><h3>Conclusions</h3><div>MNG was able to visualise the spatiotemporal course of neural currents, which is difficult to record in conventional electrophysiological examinations. Because the lesional level of the spinal cord in MRI is not always consistent with the neurological findings, MNG might be able to detect the electrophysiological change in the spinal cord at a level below the compression site.</div></div><div><h3>Significance</h3><div>MNG has the potential to be a comprehensible imaging technique and to provide novel neurological findings.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"181 ","pages":"Article 2111409"},"PeriodicalIF":3.6,"publicationDate":"2025-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145480543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-28DOI: 10.1016/j.clinph.2025.2111401
Ping Jiang , Lei Wang , Yingfan Wang , Minghao Li, Dingfeng Sun, Jing Lu, Ailiang Miao, Xiaoshan Wang
Objective
To characterize functional network abnormalities in patients with anti-leucine-rich glioma-inactivated 1 (LGI1) encephalitis using electroencephalogram (EEG) recordings.
Methods
Eleven patients and eleven controls calculated relative power spectral density (PSD) and underwent functional connectivity analysis using corrected amplitude envelope correlation (AEC-c). Amplitude envelopes were extracted across five frequency bands, and network topology was analyzed by node strength. Phase-amplitude coupling (PAC) assessed cross-frequency interactions.
Results
Patients showed significantly increased delta band power and decreased alpha band power (both p < 0.001). AEC-c analysis revealed reduced functional connectivity in delta (p = 0.0396) and gamma bands (p = 0.001), with delta band connectivity weakened between occipital and frontotemporal regions and gamma connectivity broadly diminished. No significant differences in node strength were observed. PAC analysis showed enhanced coupling in the frontal, parietal, temporal, and occipital regions (all p < 0.05).
Conclusions
Patients with anti-LGI1 encephalitis show increased delta and reduced alpha power, with decreased delta and gamma connectivity, while global network connectivity may remain partially stable, potentially supported by delta-gamma coupling.
Significance
This study highlights altered power, network abnormalities, and enhanced coupling in anti-LGI1 encephalitis, offering new insights into its pathophysiology.
{"title":"Delta/gamma band network abnormalities and enhanced phase-amplitude coupling in anti-leucine-rich glioma-inactivated 1 encephalitis","authors":"Ping Jiang , Lei Wang , Yingfan Wang , Minghao Li, Dingfeng Sun, Jing Lu, Ailiang Miao, Xiaoshan Wang","doi":"10.1016/j.clinph.2025.2111401","DOIUrl":"10.1016/j.clinph.2025.2111401","url":null,"abstract":"<div><h3>Objective</h3><div>To characterize functional network abnormalities in patients with anti-leucine-rich glioma-inactivated 1 (LGI1) encephalitis using electroencephalogram (EEG) recordings.</div></div><div><h3>Methods</h3><div>Eleven patients and eleven controls calculated relative power spectral density (PSD) and underwent functional connectivity analysis using corrected amplitude envelope correlation (AEC-c). Amplitude envelopes were extracted across five frequency bands, and network topology was analyzed by node strength. Phase-amplitude coupling (PAC) assessed cross-frequency interactions.</div></div><div><h3>Results</h3><div>Patients showed significantly increased delta band power and decreased alpha band power (both p < 0.001). AEC-c analysis revealed reduced functional connectivity in delta (p = 0.0396) and gamma bands (p = 0.001), with delta band connectivity weakened between occipital and frontotemporal regions and gamma connectivity broadly diminished. No significant differences in node strength were observed. PAC analysis showed enhanced coupling in the frontal, parietal, temporal, and occipital regions (all p < 0.05).</div></div><div><h3>Conclusions</h3><div>Patients with anti-LGI1 encephalitis show increased delta and reduced alpha power, with decreased delta and gamma connectivity, while global network connectivity may remain partially stable, potentially supported by delta-gamma coupling.</div></div><div><h3>Significance</h3><div>This study highlights altered power, network abnormalities, and enhanced coupling in anti-LGI1 encephalitis, offering new insights into its pathophysiology.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"180 ","pages":"Article 2111401"},"PeriodicalIF":3.6,"publicationDate":"2025-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145443895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-26DOI: 10.1016/j.clinph.2025.2111403
A. Schippers , J. Berezutskaya , M.J. Vansteensel , Z.V. Freudenburg , N.E. Crone , N.F. Ramsey
Objective
Brain-Computer Interfaces (BCI) provide alternative means of communication for individuals with severe motor impairment. Implantable speech BCIs have shown great potential, particularly in individuals who could still produce some speech-related movements and/or sounds. As perception of auditory feedback is important for correct speech sound production in able-bodied people, it is conceivable that a complete absence of such feedback in individuals who lost all ability to produce audible speech affects BCI performance. The current study therefore set out to investigate to what extent perception of auditory feedback of self-produced speech contributes to speech decoding performance.
Methods
In three able-bodied participants, patterns of 65–95 Hz power over sensorimotor cortex were compared between normal speech and speech in which auditory feedback was masked by noise. In addition, decoding accuracy was compared between feedback situations.
Results & Conclusions
We found subtle differences in brain activity patterns associated with speech production between situations in which participants could versus could not perceive their produced speech. Importantly, absence of such auditory feedback led to lower speech decoding performance in all participants.
Significance
These results underline the need to validate speech BCI efficacy with fully paralyzed individuals, as perceived feedback can influence the attainable speech decoding accuracy.
{"title":"The effect of perceived auditory feedback on speech Brain-Computer Interface decoding performance","authors":"A. Schippers , J. Berezutskaya , M.J. Vansteensel , Z.V. Freudenburg , N.E. Crone , N.F. Ramsey","doi":"10.1016/j.clinph.2025.2111403","DOIUrl":"10.1016/j.clinph.2025.2111403","url":null,"abstract":"<div><h3>Objective</h3><div>Brain-Computer Interfaces (BCI) provide alternative means of communication for individuals with severe motor impairment. Implantable speech BCIs have shown great potential, particularly in individuals who could still produce some speech-related movements and/or sounds. As perception of auditory feedback is important for correct speech sound production in able-bodied people, it is conceivable that a complete absence of such feedback in individuals who lost all ability to produce audible speech affects BCI performance. The current study therefore set out to investigate to what extent perception of auditory feedback of self-produced speech contributes to speech decoding performance.</div></div><div><h3>Methods</h3><div>In three able-bodied participants, patterns of 65–95 Hz power over sensorimotor cortex were compared between normal speech and speech in which auditory feedback was masked by noise. In addition, decoding accuracy was compared between feedback situations.</div></div><div><h3>Results & Conclusions</h3><div>We found subtle differences in brain activity patterns associated with speech production between situations in which participants could versus could not perceive their produced speech. Importantly, absence of such auditory feedback led to lower speech decoding performance in all participants.</div></div><div><h3>Significance</h3><div>These results underline the need to validate speech BCI efficacy with fully paralyzed individuals, as perceived feedback can influence the attainable speech decoding accuracy.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"180 ","pages":"Article 2111403"},"PeriodicalIF":3.6,"publicationDate":"2025-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145408501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-26DOI: 10.1016/j.clinph.2025.2111397
Francesco Motolese , Antonio Todisco , Licia Maria Celani , Gabriella Musumeci , Alessandro Cruciani , Davide Norata , Francesca Santoro , Mariagrazia Rossi , Fabio Pilato , Fioravante Capone , Vincenzo Di Lazzaro
Objective
Sensorimotor integration involves processing sensory input to modulate motor output through cortical-subcortical interactions. Short-latency afferent inhibition (SAI), a transcranial magnetic stimulation (TMS) protocol, is widely used to investigate this phenomenon. In this study, we investigated sensorimotor integration by assessing SAI using both contralateral (conventional protocol) and ipsilateral (experimental protocol) peripheral electrical stimulation, including interstimulus intervals (ISIs) preceding the cortical response of somatosensory evoked potentials (N20).
Methods
Twenty-four healthy participants underwent TMS over the primary motor cortex (M1), paired with either ipsilateral or contralateral median nerve stimulation at various ISIs relative to individual N20 latencies (–2 ms, –1 ms, +2 ms, +3 ms, +4 ms). Both hemispheres and stimulation conditions (ipsilateral, contralateral) were tested.
Results
Significant MEP amplitude reduction occurred with contralateral stimulation at ISIs preceding (only dominant hemisphere) and following the N20 response (both hemispheres). Ipsilateral stimulation did not modulate motor output at any ISI.
Conclusion
Our results confirm that SAI is a strictly lateralized phenomenon, occurring exclusively with contralateral peripheral stimulation and elicitable at intervals preceding the N20 response, but limited to the dominant hemisphere.
Significance
These findings emphasize the pivotal role of contralateral thalamo-cortical circuits in sensorimotor integration and provide deeper insights into the mechanisms underlying the short-latency afferent inhibition (SAI) phenomenon.
{"title":"Short-latency afferent inhibition and modulation of contralateral and ipsilateral motor output: A neurophysiological study","authors":"Francesco Motolese , Antonio Todisco , Licia Maria Celani , Gabriella Musumeci , Alessandro Cruciani , Davide Norata , Francesca Santoro , Mariagrazia Rossi , Fabio Pilato , Fioravante Capone , Vincenzo Di Lazzaro","doi":"10.1016/j.clinph.2025.2111397","DOIUrl":"10.1016/j.clinph.2025.2111397","url":null,"abstract":"<div><h3>Objective</h3><div>Sensorimotor integration involves processing sensory input to modulate motor output through cortical-subcortical interactions. Short-latency afferent inhibition (SAI), a transcranial magnetic stimulation (TMS) protocol, is widely used to investigate this phenomenon. In this study, we investigated sensorimotor integration by assessing SAI using both contralateral (conventional protocol) and ipsilateral (experimental protocol) peripheral electrical stimulation, including interstimulus intervals (ISIs) preceding the cortical response of somatosensory evoked potentials (N20).</div></div><div><h3>Methods</h3><div>Twenty-four healthy participants underwent TMS over the primary motor cortex (M1), paired with either ipsilateral or contralateral median nerve stimulation at various ISIs relative to individual N20 latencies (–2 ms, –1 ms, +2 ms, +3 ms, +4 ms). Both hemispheres and stimulation conditions (ipsilateral, contralateral) were tested.</div></div><div><h3>Results</h3><div>Significant MEP amplitude reduction occurred with contralateral stimulation at ISIs preceding (only dominant hemisphere) and following the N20 response (both hemispheres). Ipsilateral stimulation did not modulate motor output at any ISI.</div></div><div><h3>Conclusion</h3><div>Our results confirm that SAI is a strictly lateralized phenomenon, occurring exclusively with contralateral peripheral stimulation and elicitable at intervals preceding the N20 response, but limited to the dominant hemisphere.</div></div><div><h3>Significance</h3><div>These findings emphasize the pivotal role of contralateral thalamo-cortical circuits in sensorimotor integration and provide deeper insights into the mechanisms underlying the short-latency afferent inhibition (SAI) phenomenon.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"180 ","pages":"Article 2111397"},"PeriodicalIF":3.6,"publicationDate":"2025-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145408434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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